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日本語AIでPubMedを検索

歯科医師情報サイトTOP / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
対象期間    ～ 

2020年07月 みんなが読んでいる論文

ノルウェーの道路における若いドライバーが関与した重大な自動車衝突事故の発生件数（2013年～2016年スピード違反とドライバーの過失が主な課題となっている

Serious motor vehicle collisions involving young drivers on Norwegian roads 2013-2016: Speeding and driver-related errors are the main challenge.
  • Jan Mario Breen
  • Pål Aksel Næss
  • Trond Boye Hansen
  • Christine Gaarder
  • Arne Stray-Pedersen
  • Traffic Inj Prev.2020;21(6):382-388. doi: 10.1080/15389588.2020.1770237.Epub 2020-06-04.

ジアリール尿素誘導体の合成と生物学的評価：de novo構造に基づくリード最適化アプローチを用いた抗がん剤候補として設計されたジアリール尿素誘導体の合成と生物学的評価

Synthesis and biological evaluation of diaryl urea derivatives designed as potential anticarcinoma agents using de novo structure-based lead optimization approach.
  • Fereshteh Azimian
  • Maryam Hamzeh-Mivehroud
  • Javid Shahbazi Mojarrad
  • Salar Hemmati
  • Siavoush Dastmalchi
  • Eur J Med Chem.2020 Jun;201:112461. S0223-5234(20)30432-3. doi: 10.1016/j.ejmech.2020.112461.Epub 2020-06-24.

RNA-sequencingとアンターゲットLC-MSメタボロミクスを統合し、ホルスタイン子牛の肝機能に及ぼすリジン欠乏の影響を評価した

Integrating RNA-sequencing and untargeted LC-MS metabolomics to evaluate the effect of lysine deficiency on hepatic functions in Holstein calves.
  • Fanlin Kong
  • Yanliang Bi
  • Bing Wang
  • Kai Cui
  • Yuan Li
  • Tong Fu
  • Qiyu Diao
  • Yan Tu
  • Amino Acids.2020 May;52(5):781-792. 10.1007/s00726-020-02852-1. doi: 10.1007/s00726-020-02852-1.Epub 2020-05-05.

Acin1転写物の発現とスプライシングプロファイルの変化は、代替スプライシング機構を介して褐色脂肪形成を差異的に制御する

Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism.
  • Ying-Chin Lin
  • Yi-Han Lu
  • Yuan-Chii Lee
  • Ching-Sheng Hung
  • Jung-Chun Lin
  • Biochim Biophys Acta Gene Regul Mech.2020 Jul;1863(9):194601. S1874-9399(20)30184-X. doi: 10.1016/j.bbagrm.2020.194601.Epub 2020-07-03.

一次抗体欠損症における低 IgA Associated With Oropharyngeal Microbiota Changes and Lung Disease in Primary Antibody Deficiency

Low IgA Associated With Oropharyngeal Microbiota Changes and Lung Disease in Primary Antibody Deficiency.
  • Roos-Marijn Berbers
  • Firdaus A A Mohamed Hoesein
  • Pauline M Ellerbroek
  • Joris M van Montfrans
  • Virgil A S H Dalm
  • P Martin van Hagen
  • Fernanda L Paganelli
  • Marco C Viveen
  • Malbert R C Rogers
  • Pim A de Jong
  • Hae-Won Uh
  • Rob J L Willems
  • Helen L Leavis
  • Front Immunol.2020;11:1245. doi: 10.3389/fimmu.2020.01245.Epub 2020-06-19.

経カテーテル大動脈弁置換術を受ける中間リスク患者におけるベースライン6分歩行テストの成績の予後への影響

Prognostic implications of baseline 6-min walk test performance in intermediate risk patients undergoing transcatheter aortic valve replacement.
  • Janarthanan Sathananthan
  • Philip Green
  • Matthew Finn
  • David A Wood
  • Sandra Lauck
  • Aaron Crowley
  • Maria Alu
  • Suzanne V Arnold
  • David Cohen
  • Samir Kapadia
  • Michael Mack
  • Vinod H Thourani
  • Susheel Kodali
  • Martin Leon
  • John G Webb
  • Catheter Cardiovasc Interv.2020 Jun;doi: 10.1002/ccd.28981.Epub 2020-06-10.

新規にうつ病と診断された患者と2型糖尿病または高血圧患者におけるセルトラリンの効果。南インドからの観察研究

Effect of sertraline in patients with newly diagnosed depression and type 2 diabetes mellitus or hypertension: An observational study from south India.
  • C Padmapriya
  • S Pushkarapriya
  • N Shanmugapriya
  • K P Sushmitha
  • S Karthik
  • M G Rajanandh
  • Diabetes Metab Syndr.2020 Jun;14(5):1065-1068. S1871-4021(20)30228-9. doi: 10.1016/j.dsx.2020.06.059.Epub 2020-06-30.

IgA腎症とヘノック・シェーンレーニン紫斑病腎炎の日本人小児における疾患活動性のバイオマーカーとしてのマクロファージのアポトーシス阻害剤

Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schönlein purpura nephritis.
  • Hitoshi Irabu
  • Masaki Shimizu
  • Shuya Kaneko
  • Natsumi Inoue
  • Mao Mizuta
  • Yuko Tasaki
  • Kazuhide Ohta
  • Akihiro Yachie
  • Taizo Wada
  • Pediatr. Res..2020 May;10.1038/s41390-020-0951-1. doi: 10.1038/s41390-020-0951-1.Epub 2020-05-14.

Multistrainプロバイオティクスは、肥満妊婦の腸内細菌叢の多様性を増加させます。無作為化二重盲検プラセボ対照試験の結果

Multistrain Probiotic Increases the Gut Microbiota Diversity in Obese Pregnant Women: Results from a Randomized, Double-Blind Placebo-Controlled Study.
  • Sofie Ingdam Halkjær
  • Victoria Elizabeth de Knegt
  • Bobby Lo
  • Lisbeth Nilas
  • Dina Cortes
  • Anders Elm Pedersen
  • Hengameh Chloé Mirsepasi-Lauridsen
  • Lee O'Brien Andersen
  • Henrik Vedel Nielsen
  • Christen Rune Stensvold
  • Thor Bech Johannesen
  • Thomas Kallemose
  • Karen Angeliki Krogfelt
  • Andreas Munk Petersen
  • Curr Dev Nutr.2020 Jul;4(7):nzaa095. nzaa095. doi: 10.1093/cdn/nzaa095.Epub 2020-05-27.

サイトカイン放出症候群（CRS）の文脈での IL-6 血清レベルと CAR-T 細胞特異的デジタル PCR の解析

Analysis of IL-6 serum levels and CAR-T cell specific digital PCR in the context of cytokine release syndrome (CRS).
  • Thomas Pabst
  • Raphael Joncourt
  • Evgenii Shumilov
  • Alexander Heini
  • Gertrud Wiedemann
  • Myriam Legros
  • Katja Seipel
  • Christof Schild
  • Katarzyna Jalowiec
  • Behrouz Mansouri
  • Michaela Fux
  • Urban Novak
  • Naomi Porret
  • Sacha Zeerleder
  • Ulrike Bacher
  • Exp. Hematol..2020 Jul;S0301-472X(20)30268-X. doi: 10.1016/j.exphem.2020.07.003.Epub 2020-07-13.

開業医によるCoViD-19患者の在宅管理を支援するためのテレビ電話相談：マルケ州のいくつかの自治体での結果

[The televideoconsultation in support of home management of the patient with CoViD-19 by general practitioner: the results in some municipalities of the Marche Region.]
  • Pierpaolo Morosini
  • Nando Campanella
  • Gina Lucci
  • Amedeo Giorgetti
  • Vanni Lorenzetti
  • Ercolano Manfrini
  • Alfredo Moretti
  • Recenti Prog Med.2020 Jul-Aug;111(7):454-460. doi: 10.1701/3407.33927.

急性前骨髄球性白血病患者に全トランスレチノイン酸と化学療法を施行した場合，最初の連結後に測定可能な残存病変が予後を予測する．

Measurable residual disease after the first consolidation predicts the outcomes of patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy.
  • Hideho Henzan
  • Ken Takase
  • Tomohiko Kamimura
  • Yasuo Mori
  • Goichi Yoshimoto
  • Hiromi Iwasaki
  • Koji Nagafuji
  • Ryosuke Ogawa
  • Tetsuya Eto
  • Naoyuki Uchida
  • Tomoaki Fujisaki
  • Koji Kato
  • Mariko Minami
  • Yoshikane Kikushige
  • Koichi Akashi
  • Toshihiro Miyamoto
  • Int. J. Hematol..2020 Jun;10.1007/s12185-020-02911-z. doi: 10.1007/s12185-020-02911-z.Epub 2020-06-10.

エクソンスキップ機構の翻訳後制御が白血病の異常スプライシングを制御していることを明らかにした

Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia.
  • Yalu Zhou
  • Cuijuan Han
  • Eric Wang
  • Adam H Lorch
  • Valentina Serafin
  • Byoung-Kyu Cho
  • Blanca T Guttierrez Diaz
  • Julien Calvo
  • Celestia Fang
  • Alireza Khodadadi-Jamayran
  • Tommaso Tabaglio
  • Christian Marier
  • Anna Kuchmiy
  • Limin Sun
  • George Yacu
  • Szymon K Filip
  • Qi Jin
  • Yoh-Hei Takahashi
  • David R Amici
  • Emily J Rendleman
  • Radhika Rawat
  • Silvia Bresolin
  • Maddalena Paganin
  • Cheng Zhang
  • Hu Li
  • Irawati Kandela
  • Yuliya Politanska
  • Hiam Abdala-Valencia
  • Marc L Mendillo
  • Ping Zhu
  • Bruno Palhais
  • Pieter Van Vlierberghe
  • Tom Taghon
  • Iannis Aifantis
  • Young Ah Goo
  • Ernesto Guccione
  • Adriana Heguy
  • Aristotelis Tsirigos
  • Keng Boon Wee
  • Rama K Mishra
  • Francoise Pflumio
  • Benedetta Accordi
  • Giuseppe Basso
  • Panagiotis Ntziachristos
  • Cancer Discov.2020 May;CD-19-1436. doi: 10.1158/2159-8290.CD-19-1436.Epub 2020-05-22.

遠隔虚血性プリコンディショニングは、非アシル化グレリンによるJAK/STAT経路の活性化を介して心筋虚血再灌流傷害を軽減する

Remote ischemic preconditioning reduces myocardial ischemia-reperfusion injury through unacylated ghrelin-induced activation of the JAK/STAT pathway.
  • Yasuaki Sawashita
  • Naoyuki Hirata
  • Yusuke Yoshikawa
  • Hirofumi Terada
  • Yasuyuki Tokinaga
  • Michiaki Yamakage
  • Basic Res. Cardiol..2020 Jun;115(4):50. 10.1007/s00395-020-0809-z. doi: 10.1007/s00395-020-0809-z.Epub 2020-06-30.

HIV感染症を持つ抗レトロウイルス剤を服用していない妊婦を対象としたRaltegravirとefavirenzの比較試験（NICHD P1081）：非盲検、無作為化、対照、第4相試験

Raltegravir versus efavirenz in antiretroviral-naive pregnant women living with HIV (NICHD P1081): an open-label, randomised, controlled, phase 4 trial.
  • Esaú C João
  • R Leavitt Morrison
  • David E Shapiro
  • Nahida Chakhtoura
  • Maria Isabel S Gouvèa
  • Maria de Lourdes B Teixeira
  • Trevon L Fuller
  • Blandina T Mmbaga
  • James S Ngocho
  • Boniface N Njau
  • Avy Violari
  • Ruth Mathiba
  • Zaakirah Essack
  • Jose Henrique S Pilotto
  • Luis Felipe Moreira
  • Maria Jose Rolon
  • Pedro Cahn
  • Sinart Prommas
  • Timothy R Cressey
  • Kulkanya Chokephaibulkit
  • Peerawong Werarak
  • Lauren Laimon
  • Roslyn Hennessy
  • Lisa M Frenkel
  • Patricia Anthony
  • Brookie M Best
  • George K Siberry
  • Mark Mirochnick
  • Lancet HIV.2020 May;7(5):e322-e331. S2352-3018(20)30038-2. doi: 10.1016/S2352-3018(20)30038-2.

アンモニア処理鶏脾臓リンパ球におけるmiR-15aによるアポトーシスとミトコンドリア経路を介した酸化ストレスの発生にNF-κB経路が関与していることを明らかにしました

NF-κB pathway took part in the development of apoptosis mediated by miR-15a and oxidative stress via mitochondrial pathway in ammonia-treated chicken splenic lymphocytes.
  • Dechun Chen
  • Fangyong Ning
  • Jingyang Zhang
  • You Tang
  • Xiaohua Teng
  • Sci. Total Environ..2020 Aug;729:139017. S0048-9697(20)32534-1. doi: 10.1016/j.scitotenv.2020.139017.Epub 2020-04-26.

肝硬変誘発性肝性脳症に対するホスファチジルセリンの効果。肝硬変ラットにおける急性エンドトキシン血症への反応

Effect of phosphatidylserine on cirrhosis-induced hepatic encephalopathy: Response to acute endotoxemia in cirrhotic rats.
  • Golnaz Zamanian
  • Alireza Partoazar
  • Seyed Mohammad Tavangar
  • Amir Rashidian
  • Parto Mirzaei
  • Qamar Niaz
  • Khadijeh Sharifi
  • Ahmad Reza Dehpour
  • Farahnaz Jazaeri
  • Life Sci..2020 Jul;253:117606. S0024-3205(20)30354-4. doi: 10.1016/j.lfs.2020.117606.Epub 2020-04-19.

リツキシマブによる治療後の体液性免疫不全を有する B 細胞非ホジキンリンパ腫患者における 20%皮下免疫グロブリン補充療法の使用

The Use of 20% Subcutaneous Immunoglobulin Replacement Therapy in Patients With B Cell Non-Hodgkin Lymphoma With Humoral Immune Dysfunction After Treatment With Rituximab.
  • S Shahzad Mustafa
  • Saad Jamshed
  • Karthik Vadamalai
  • Allison Ramsey
  • Clin Lymphoma Myeloma Leuk.2020 May;S2152-2650(20)30184-1. doi: 10.1016/j.clml.2020.04.006.Epub 2020-05-08.

アジアン酸はAMPK/PI3K/AKTシグナル伝達経路を介して関節軟骨細胞の肥大と線維化分化を減衰させる

Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway.
  • Na Liu
  • Dejie Fu
  • Junjun Yang
  • Pingju Liu
  • Xiongbo Song
  • Xin Wang
  • Rui Li
  • Zhenlan Fu
  • Jiajia Chen
  • Xiaoyuan Gong
  • Cheng Chen
  • Liu Yang
  • Arthritis Res. Ther..2020 05;22(1):112. 10.1186/s13075-020-02193-0. doi: 10.1186/s13075-020-02193-0.Epub 2020-05-12.

犬の創傷治癒に対するアマゾン植物由来の植物性医薬品の有効性

Efficacy of Phytopharmaceuticals From the Amazonian Plant for Wound Healing in Dogs.
  • Ádria Vanessa Linhares Dos Santos Américo
  • Kariane Mendes Nunes
  • Francisco Flávio Vieira de Assis
  • Salatiel Ribeiro Dias
  • Carla Tatiane Seixas Passos
  • Adriana Caroprezo Morini
  • Junior Avelino de Araújo
  • Kelly Christina Ferreira Castro
  • Silvia Katrine Rabelo da Silva
  • Lauro Euclides Soares Barata
  • Antonio Humberto Hamad Minervino
  • Front Vet Sci.2020;7:244. doi: 10.3389/fvets.2020.00244.Epub 2020-06-12.

骨髄間質細胞由来のmicroRNA-181含有細胞外小胞は、Wnt/β-カテニンシグナル伝達経路を介してMESTをダウンレギュレートすることで、卵巣癌細胞の化学抵抗性を抑制する

Bone marrow stromal cells-derived microRNA-181-containing extracellular vesicles inhibit ovarian cancer cell chemoresistance by downregulating MEST via the Wnt/β-catenin signaling pathway.
  • Zhengyi Ruan
  • Lili Lu
  • Li Zhang
  • Min Dong
  • Cancer Gene Ther..2020 Jul;10.1038/s41417-020-0195-6. doi: 10.1038/s41417-020-0195-6.Epub 2020-07-07.

二次性進行性多発性硬化症（MS-SMART）における3種類の神経保護薬の有効性：第2b相、多群、二重盲検、無作為化プラセボ対照試験

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial.
  • Jeremy Chataway
  • Floriana De Angelis
  • Peter Connick
  • Richard A Parker
  • Domenico Plantone
  • Anisha Doshi
  • Nevin John
  • Jonathan Stutters
  • David MacManus
  • Ferran Prados Carrasco
  • Frederik Barkhof
  • Sebastien Ourselin
  • Marie Braisher
  • Moira Ross
  • Gina Cranswick
  • Sue H Pavitt
  • Gavin Giovannoni
  • Claudia Angela Gandini Wheeler-Kingshott
  • Clive Hawkins
  • Basil Sharrack
  • Roger Bastow
  • Christopher J Weir
  • Nigel Stallard
  • Siddharthan Chandran
  • Lancet Neurol.2020 03;19(3):214-225. S1474-4422(19)30485-5. doi: 10.1016/S1474-4422(19)30485-5.Epub 2020-01-22.

シロチョウザメ(Acipenser transmontanus)のアリール炭化水素受容体核内トランスロケータ(ARNT1, ARNT2, ARNT3)。その配列、組織特異的発現、β-ナフトフラボンに対する応答

Aryl hydrocarbon receptor nuclear translocators (ARNT1, ARNT2, and ARNT3) of white sturgeon (Acipenser transmontanus): Sequences, tissue-specific expressions, and response to β-naphthoflavone.
  • Jon A Doering
  • Shawn C Beitel
  • Sarah Patterson
  • Bryanna K Eisner
  • John P Giesy
  • Markus Hecker
  • Steve Wiseman
  • Comp. Biochem. Physiol. C Toxicol. Pharmacol..2020 May;231:108726. S1532-0456(20)30026-0. doi: 10.1016/j.cbpc.2020.108726.Epub 2020-02-17.

環境に関連したベンゾアピレンへの短期の水性曝露に対する雄と雌のファットヘッドミノー（Pimephales promelas）の腸内細菌叢の応答の違い

Differential responses of gut microbiota of male and female fathead minnow (Pimephales promelas) to a short-term environmentally-relevant, aqueous exposure to benzo[a]pyrene.
  • Abigail DeBofsky
  • Yuwei Xie
  • Chelsea Grimard
  • Alper James Alcaraz
  • Markus Brinkmann
  • Markus Hecker
  • John P Giesy
  • Chemosphere.2020 Aug;252:126461. S0045-6535(20)30654-8. doi: 10.1016/j.chemosphere.2020.126461.Epub 2020-03-12.

β-ナフトフラボンに曝露したヒト初代ケラチノサイトの時間的トランスクリプトーム解析から、環境汚染物質に対する皮膚の保護効果が明らかになった

Temporal transcriptomic analysis of human primary keratinocytes exposed to β-naphthoflavone highlights the protective efficacy of skin to environmental pollutants.
  • Paul Quantin
  • Angela Patatian
  • Maxime Floreani
  • Christophe Egles
  • Philippe Benech
  • Hervé Ficheux
  • Toxicol In Vitro.2020 Jun;65:104822. S0887-2333(19)30857-4. doi: 10.1016/j.tiv.2020.104822.Epub 2020-03-06.

2,3,4,5,6-ペンタフルオロベンジルブロマイド誘導体化とガスクロマトグラフィー質量分析による水中の7つのパーフルオロアルキルカルボン酸の同時測定

Simultaneous determination of seven perfluoroalkyl carboxylic acids in water samples by 2,3,4,5,6-pentafluorobenzyl bromide derivatization and gas chromatography-mass spectrometry.
  • Yongyan Ji
  • Zongyan Cui
  • Zhibin Wang
  • Yanzhong Cao
  • Xuemin Li
  • Adan Li
  • Environ. Pollut..2020 Jun;266(Pt 3):115043. S0269-7491(19)33751-0. doi: 10.1016/j.envpol.2020.115043.Epub 2020-06-21.

頸部前膜および/または側方脊柱管狭窄症を原因とする頸部脊椎症性橈骨症を対象とした後頸部経皮内視鏡的腹側骨減圧療法と単純背側骨減圧療法の比較検討：臨床レトロスペクティブ研究

A comparison study of posterior cervical percutaneous endoscopic ventral bony decompression and simple dorsal decompression treatment in cervical spondylotic radiculopathy caused by cervical foraminal and/or lateral spinal stenosis: a clinical retrospective study.
  • Yuexin Tong
  • Zhangheng Huang
  • Chuan Hu
  • Zhiyi Fan
  • Fucheng Bian
  • Fengkai Yang
  • Chengliang Zhao
  • BMC Musculoskelet Disord.2020 May;21(1):290. 10.1186/s12891-020-03313-2. doi: 10.1186/s12891-020-03313-2.Epub 2020-05-11.

ジアゼパム、メトホルミン、オメプラゾール、シムバスタチン：個々の急性毒性と混合物の急性毒性の完全な議論

Diazepam, metformin, omeprazole and simvastatin: a full discussion of individual and mixture acute toxicity.
  • Raquel Sampaio Jacob
  • Lucilaine Valéria de Souza Santos
  • Mirna d'Auriol
  • Yuri Abner Rocha Lebron
  • Victor Rezende Moreira
  • Liséte Celina Lange
  • Ecotoxicology.2020 Jun;10.1007/s10646-020-02239-8. doi: 10.1007/s10646-020-02239-8.Epub 2020-06-25.

慢性的なセロトニン再取り込み阻害は、過食ラットにおいて褐色脂肪のミトコンドリアの結合を解除し、白色脂肪の褐変/褐変過程を誘導する

Chronic serotonin reuptake inhibition uncouples brown fat mitochondria and induces beiging/browning process of white fat in overfed rats.
  • Glauber Rudá F Braz
  • Aline Isabel da Silva
  • Severina Cássia A Silva
  • Anderson Apolonio S Pedroza
  • Maria Daniele T B de Lemos
  • Flávia Ariane S de Lima
  • Tercya Lúcidi A Silva
  • Claudia Jacques Lagranha
  • Life Sci..2020 Mar;245:117307. S0024-3205(20)30054-0. doi: 10.1016/j.lfs.2020.117307.Epub 2020-01-16.

びまん性大細胞型B細胞リンパ腫におけるCHOP治療における抗アポトーシスBCL-2ファミリー蛋白質への依存性の異質パターン

Heterogeneous Pattern of Dependence on Anti-Apoptotic BCL-2 Family Proteins upon CHOP Treatment in Diffuse Large B-Cell Lymphoma.
  • Mathilde Rikje Willemijn de Jong
  • Myra Langendonk
  • Bart Reitsma
  • Marcel Nijland
  • Anke van den Berg
  • Emanuele Ammatuna
  • Lydia Visser
  • Tom van Meerten
  • Int J Mol Sci.2019 Nov;20(23). E6036. doi: 10.3390/ijms20236036.Epub 2019-11-30.

ラットにおけるインドメタシン誘発性胃傷害に対する胃保護のための最適化されたエラグ酸-Caペクチネート浮遊ビーズ

Optimized Ellagic Acid-Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats.
  • Nabil A Alhakamy
  • Shaimaa M Badr-Eldin
  • Osama A A Ahmed
  • Abdulrahman A Halwani
  • Hibah M Aldawsari
  • Mohamed A El-Moselhy
  • Aliaa Anter
  • Sara S Sharkawi
  • Muhammad H Sultan
  • Osama A A Madkhali
  • Muhammed A Bakhrebah
  • Mohammad N Alomary
  • Wesam H Abdulaal
  • Usama A Fahmy
  • Biomolecules.2020 Jul;10(7). E1006. doi: 10.3390/biom10071006.Epub 2020-07-06.

ストロングハート研究およびストロングハートファミリー研究における母親のヒ素曝露と成人の空腹時血糖値およびインスリン抵抗性との関連

Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study.
  • Naomi E Tinkelman
  • Miranda Jones Spratlen
  • Arce Domingo-Relloso
  • Maria Tellez-Plaza
  • Maria Grau-Perez
  • Kevin A Francesconi
  • Walter Goessler
  • Barbara V Howard
  • Jean MacCluer
  • Kari E North
  • Jason G Umans
  • Pam Factor-Litvak
  • Shelley A Cole
  • Ana Navas-Acien
  • Environ Int.2020 Apr;137:105531. S0160-4120(19)32611-X. doi: 10.1016/j.envint.2020.105531.Epub 2020-02-18.

変異型SOD1マウスの脳幹の単細胞RNA-seq解析により、筋萎縮性側索硬化症の細胞型と経路が変化していることが明らかになった

Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis.
  • Wenting Liu
  • Sharmila Venugopal
  • Sana Majid
  • In Sook Ahn
  • Graciel Diamante
  • Jason Hong
  • Xia Yang
  • Scott H Chandler
  • Neurobiol. Dis..2020 Jul;141:104877. S0969-9961(20)30152-2. doi: 10.1016/j.nbd.2020.104877.Epub 2020-04-30.

慢性拘縮性心膜炎患者におけるガレクチン-3レベル

Galectin-3 Levels in Patients with Chronic Constrictive Pericarditis.
  • Fábio Fernandes
  • Dirceu Thiago Pessoa de Melo
  • Felix José Alvarez Ramires
  • Ester Cerdeira Sabino
  • Carlos Henrique Valente Moreira
  • Luiz Alberto Benvenutti
  • Viviane Tiemi Hotta
  • Ana Luiza Carrari Sayegh
  • Francis Ribeiro de Souza
  • Ricardo Ribeiro Dias
  • Charles Mady
  • Arq. Bras. Cardiol..2020 04;114(4):683-689. S0066-782X2020000400683. doi: 10.36660/abc.20190152.Epub 2020-05-29.

低用量アスピリンで子癇前症を発症した女性におけるエイコサノイドとスフィンゴ脂質の胎盤生産

Placental Production of Eicosanoids and Sphingolipids in Women Who Developed Preeclampsia on Low-Dose Aspirin.
  • Scott W Walsh
  • Daniel T Reep
  • S M Khorshed Alam
  • Sonya L Washington
  • Marwah Al Dulaimi
  • Stephanie M Lee
  • Edward H Springel
  • Jerome F Strauss
  • Daniel J Stephenson
  • Charles E Chalfant
  • Reprod Sci.2020 Jun;10.1007/s43032-020-00234-2. doi: 10.1007/s43032-020-00234-2.Epub 2020-06-17.

牛乳から分離された黄色ブドウ球菌のゲノム解析による多様性の解明と抗菌性および病原性遺伝子の分布、および乳腺炎との関連性の決定

Genomic Analysis of Bovine Staphylococcus aureus Isolates from Milk To Elucidate Diversity and Determine the Distributions of Antimicrobial and Virulence Genes and Their Association with Mastitis.
  • Sohail Naushad
  • Diego B Nobrega
  • S Ali Naqvi
  • Herman W Barkema
  • Jeroen De Buck
  • mSystems.2020 Jul;5(4). e00063-20. doi: 10.1128/mSystems.00063-20.Epub 2020-07-07.

食事脂肪はステロール代謝に関連する遺伝子の発現に影響を与え、ラットの盲腸微生物叢とその代謝物の組成に影響を与えている

Dietary Fat Influences the Expression of Genes Related to Sterol Metabolism and the Composition of Cecal Microbiota and Its Metabolites in Rats.
  • Ryota Hosomi
  • Anna Matsudo
  • Koki Sugimoto
  • Takaki Shimono
  • Seiji Kanda
  • Toshimasa Nishiyama
  • Munehiro Yoshida
  • Kenji Fukunaga
  • J Oleo Sci.2019;68(11):1133-1147. doi: 10.5650/jos.ess19183.

miR-17-5pは、コラーゲン誘導関節炎マウスの炎症と骨びらんを減少させ、関節リウマチ線維芽細胞様滑膜細胞のJAK-STAT経路を直接標的としている

miR-17-5p reduces inflammation and bone erosions in collagen induced arthritis mice and directly targets the JAK-STAT pathway in rheumatoid arthritis fibroblast-like synoviocytes.
  • Aurélie Najm
  • François-Marie Masson
  • Pauline Preuss
  • Steven Georges
  • Benjamin Ory
  • Thibaut Quillard
  • Shatakshi Sood
  • Carl S Goodyear
  • Douglas J Veale
  • Ursula Fearon
  • Benoit Le Goff
  • Frédéric Blanchard
  • 2020 Jul;doi: 10.1002/art.41441.Epub 2020-07-19.

糖尿病創傷の治癒を促進する創傷被覆材として、ギ酸脱細胞化ペプシン可溶性細胞外マトリックスハイドロゲルとサッカキチンハイドロゲルからなる新規複合ハイドロゲルを開発した

A Novel Composite Hydrogel Composed of Formic Acid-Decellularized Pepsin-Soluble Extracellular Matrix Hydrogel and Sacchachitin Hydrogel as Wound Dressing to Synergistically Accelerate Diabetic Wound Healing.
  • Chien-Ming Hsieh
  • Weu Wang
  • Ying-Hsuan Chen
  • Pu-Sheng Wei
  • Yu-Hsuan Liu
  • Ming-Thau Sheu
  • Hsiu-O Ho
  • Pharmaceutics.2020 Jun;12(6). E538. doi: 10.3390/pharmaceutics12060538.Epub 2020-06-11.

マイクロ波真空熱分解を応用して、きのこ生産のための保湿性とpH中和性のあるパーム核殻バイオ炭を設計する

Applying microwave vacuum pyrolysis to design moisture retention and pH neutralizing palm kernel shell biochar for mushroom production.
  • Wan Adibah Wan Mahari
  • Wai Lun Nam
  • Christian Sonne
  • Wanxi Peng
  • Xue Yee Phang
  • Rock Keey Liew
  • Peter Nai Yuh Yek
  • Xie Yi Lee
  • Ou Wei Wen
  • Pau Loke Show
  • Wei-Hsin Chen
  • Jo-Shu Chang
  • Su Shiung Lam
  • Bioresour. Technol..2020 Sep;312:123572. S0960-8524(20)30844-0. doi: 10.1016/j.biortech.2020.123572.Epub 2020-05-23.

閉塞性睡眠時無呼吸症候群（OSAS）と小児の胸郭奇形の発症との相関性に関する研究。中国におけるレトロスペクティブな単施設研究

Study on the correlation between OSAS and thoracic deformity in children: A retrospective single-center study in China.
  • Ying-Ge Wang
  • Chang Lin
  • Sheng-Nan Ye
  • Yuan-Teng Xu
  • Xiao-Hong Lin
  • Xiao-Ying Ke
  • Jin-Xing Zheng
  • Ying Chen
  • Guo-Hao Chen
  • Int. J. Pediatr. Otorhinolaryngol..2020 Jul;137:110226. S0165-5876(20)30369-4. doi: 10.1016/j.ijporl.2020.110226.Epub 2020-07-11.

モノクローナル抗体を合理的に最適化することで、医薬品プロセスチェーン全体の凝集性を向上させ、CMC特性を向上させることができます

Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain.
  • Joschka Bauer
  • Sven Mathias
  • Sebastian Kube
  • Kerstin Otte
  • Patrick Garidel
  • Martin Gamer
  • Michaela Blech
  • Simon Fischer
  • Anne R Karow-Zwick
  • MAbs.2020 Jan-Dec;12(1):1787121. doi: 10.1080/19420862.2020.1787121.

mTORC2は成長因子シグナルと鉄代謝のエピジェネティックな制御に関係している

mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma.
  • Kenta Masui
  • Mio Harachi
  • Shiro Ikegami
  • Huijun Yang
  • Hiromi Onizuka
  • William H Yong
  • Timothy F Cloughesy
  • Yoshihiro Muragaki
  • Takakazu Kawamata
  • Nobutaka Arai
  • Takashi Komori
  • Webster K Cavenee
  • Paul S Mischel
  • Noriyuki Shibata
  • J. Biol. Chem..2019 12;294(51):19740-19751. RA119.011519. doi: 10.1074/jbc.RA119.011519.Epub 2019-11-11.

フルダラビン、カンパス、低用量シクロホスファミド（FCC）のTBI条件付き、またはTBI条件なしでの投与は、重度の再生不良性貧血を有する小児における優れた移植成績をもたらす

Fludarabine, Campath and Low dose Cyclophosphamide (FCC) with or without TBI Conditioning Results in Excellent Transplant Outcomes in Children with Severe Aplastic Anemia.
  • Ravi M Shah
  • Tony H Truong
  • Michel T Leaker
  • Nicola Am Wright
  • Doan Le
  • MacGregor Steele
  • Aisha Ak Bruce
  • Sunil Desai
  • Gregory Mt Guilcher
  • Victor Lewis
  • Biol. Blood Marrow Transplant..2020 Jul;S1083-8791(20)30404-3. doi: 10.1016/j.bbmt.2020.06.027.Epub 2020-07-05.

MRIを標的とした複合的確認生検と系統的確認生検の併用により、前立腺がんの積極的サーベイランスに登録された患者のリスク層別化が改善された

Combined MRI-targeted plus systematic confirmatory biopsy improves risk stratification for patients enrolling on active surveillance for prostate cancer.
  • Luke P O'Connor
  • Alex Z Wang
  • Nitin K Yerram
  • Amir H Lebastchi
  • Michael Ahdoot
  • Sandeep Gurram
  • Johnathan Zeng
  • Sherif Mehralivand
  • Stephanie Harmon
  • Maria J Merino
  • Howard L Parnes
  • Peter L Choyke
  • Baris Turkbey
  • Bradford J Wood
  • Peter A Pinto
  • Urology.2020 Jul;S0090-4295(20)30828-1. doi: 10.1016/j.urology.2020.06.061.Epub 2020-07-14.

TM9SF4は、新規なV-ATPaseと相互作用するタンパク質であり、結腸癌細胞の薬剤耐性や浸潤性に関連した腫瘍pHの変化を調節します

TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells.
  • F Lozupone
  • M Borghi
  • F Marzoli
  • T Azzarito
  • P Matarrese
  • E Iessi
  • G Venturi
  • S Meschini
  • A Canitano
  • R Bona
  • A Cara
  • S Fais
  • Oncogene.2015 Oct;34(40):5163-74. onc2014437. doi: 10.1038/onc.2014.437.Epub 2015-02-09.

カフェイン酸フェネチルエステルを用いた象牙質前処理後の象牙質マトリックス安定性とゼラチン分解活性の長期評価

Long-term Evaluation of Dentin Matrix Stability and Gelatinolytic Activity after Dentin Pretreatment with Caffeic Acid Phenethyl Ester.
  • Vivianne Oliveira Pedrosa
  • Enrico Coser Bridi
  • Ariene Arcas Leme-Kraus
  • Fabiana Mantovani Gomes França
  • Cecilia Pedroso Turssi
  • Flávia Lucisano Botelho do Amaral
  • Lucas Novaes Teixeira
  • Elizabeth Ferreira Martinez
  • Ana Karina Bedran-Russo
  • Roberta Tarkany Basting
  • J Adhes Dent.2020;22(3):285-296. 44552. doi: 10.3290/j.jad.a44552.

エチオピア・アディスアベバの子宮頸がん検診サービスに通う女性における子宮頸がん検診受診率、酢酸陽性による目視検査、およびその予測因子に影響を与える要因

Factors affecting cervical cancer screening uptake, visual inspection with acetic acid positivity and its predictors among women attending cervical cancer screening service in Addis Ababa, Ethiopia.
  • Atalay Mulu Fentie
  • Tamir Birhanu Tadesse
  • Gebremedhin Beedemariam Gebretekle
  • BMC Womens Health.2020 Jul;20(1):147. 10.1186/s12905-020-01008-3. doi: 10.1186/s12905-020-01008-3.Epub 2020-07-16.

ホスホジエステラーゼ-5阻害薬とβ遮断薬の併用は、実験的に門脈高血圧と勃起不全を改善する

Combination of phosphodiesterase-5-inhibitors and beta blockers improves experimental portal hypertension and erectile dysfunction.
  • Frank Erhard Uschner
  • Kathleen Glückert
  • Rafael Paternostro
  • Thorsten Gnad
  • Robert Schierwagen
  • Mattias Mandorfer
  • Fernando Magdaleno
  • Cristina Ortiz
  • Katharina Schwarzkopf
  • Patrick Kamath
  • Carlo Alessandria
  • Christoph Boesecke
  • Alexander Pfeifer
  • Thomas Reiberger
  • Wolfgang Kreisel
  • Tilman Sauerbruch
  • Arnulf Ferlitsch
  • Jonel Trebicka
  • Sabine Klein
  • Liver Int..2020 Jul;doi: 10.1111/liv.14586.Epub 2020-07-06.

不顕性乳房炎とコアグラーゼ陰性ブドウ球菌による乳房内感染が牛乳ペプチドームに及ぼす影響

Influence of subclinical mastitis and intramammary infection by coagulase-negative staphylococci on the cow milk peptidome.
  • Maria Filippa Addis
  • Elisa Margherita Maffioli
  • Fabrizio Ceciliani
  • Gabriella Tedeschi
  • Valentina Zamarian
  • Francesco Tangorra
  • Mariangela Albertini
  • Renata Piccinini
  • Valerio Bronzo
  • J Proteomics.2020 Jul;226:103885. S1874-3919(20)30253-0. doi: 10.1016/j.jprot.2020.103885.Epub 2020-07-07.

転移性乳がん治療のためのxCT細胞外ドメインを有するVLPベースのワクチンの開発

Development of a VLP-Based Vaccine Displaying an xCT Extracellular Domain for the Treatment of Metastatic Breast Cancer.
  • Valeria Rolih
  • Jerri Caldeira
  • Elisabetta Bolli
  • Ahmad Salameh
  • Laura Conti
  • Giuseppina Barutello
  • Federica Riccardo
  • Jolanda Magri
  • Alessia Lamolinara
  • Karla Parra
  • Paloma Valenzuela
  • Giulio Francia
  • Manuela Iezzi
  • Federica Pericle
  • Federica Cavallo
  • Cancers (Basel).2020 Jun;12(6). E1492. doi: 10.3390/cancers12061492.Epub 2020-06-08.

インド・ムンバイのスラムに住む思春期の若者とその介護者の間で、ジャンクフード消費と身体活動に関連したコンフリクトが発生していることを明らかにした

Conflicts between adolescents and their caregivers living in slums of Mumbai, India in relation to junk food consumption and physical activity.
  • Harsha Vipin Chopra
  • Meera Jayant Gandhi
  • Sirazul Ameen Sahariah
  • Susie Weller
  • Ramesh Dattatray Potdar
  • Mary Barker
  • Sarah Helen Kehoe
  • Caroline Hd Fall
  • Polly Hardy-Johnson
  • Public Health Nutr.2020 Jul;:1-11. S1368980020001640. doi: 10.1017/S1368980020001640.Epub 2020-07-13.

HMG-CoA阻害薬による腎障害の保護．アトルバスタチンとロスバスタチンの比較試験

Protection of renal damage by HMG-CoA inhibitors: A comparative study between atorvastatin and rosuvastatin.
  • Maryam Jabarpour
  • Nadereh Rashtchizadeh
  • Amir Ghorbani Haghjo
  • Hassan Argani
  • Mahboub Nemati
  • Siavoush Dastmalchi
  • Leila Roshangar
  • Masoumeh Ranjbarzadhag
  • Mehran Mesgari-Abbasi
  • Nasrin Bargahi
  • Davoud Sanajou
  • Iran J Basic Med Sci.2020 Feb;23(2):206-213. doi: 10.22038/IJBMS.2019.38239.9080.

2 段階のフィードバッチ法による工業的に有用な酸化酵素の高レベル生産：アラビノース誘導性大腸菌系における異化抑制の克服

High-level production of industrially relevant oxidases by a two-stage fed-batch approach: overcoming catabolite repression in arabinose-inducible Escherichia coli systems.
  • Ramón Román
  • Nikola Lončar
  • Antoni Casablancas
  • Marco W Fraaije
  • Glòria Gonzalez
  • Appl. Microbiol. Biotechnol..2020 Jun;104(12):5337-5345. 10.1007/s00253-020-10622-y. doi: 10.1007/s00253-020-10622-y.Epub 2020-04-22.

医薬品製剤中の浸透を特性化するためのUVイメージング機能を備えた新規3Dプリント拡散セルの設計と開発

Design and development of a novel fused filament fabrication (FFF) 3D printed diffusion cell with UV imaging capabilities to characterise permeation in pharmaceutical formulations.
  • Zayeem Fazili
  • Adam Ward
  • Karl Walton
  • Liam Blunt
  • Kofi Asare-Addo
  • Eur J Pharm Biopharm.2020 Jul;152:202-209. S0939-6411(20)30141-7. doi: 10.1016/j.ejpb.2020.05.013.Epub 2020-05-19.

神経伝達物質の放出：パーキンソン病、アルツハイマー病、精神疾患の遺伝子治療または細胞治療における液胞ATPase V0セクターのc-サブユニットの可能性

Neurotransmitter release: vacuolar ATPase V0 sector c-subunits in possible gene or cell therapies for Parkinson's, Alzheimer's, and psychiatric diseases.
  • Haruhiro Higashida
  • Shigeru Yokoyama
  • Chiharu Tsuji
  • Shin-Ichi Muramatsu
  • J Physiol Sci.2017 Jan;67(1):11-17. 10.1007/s12576-016-0462-3. doi: 10.1007/s12576-016-0462-3.Epub 2016-06-11.

血漿エイコサノイドは、非アルコール性ステアト肝炎患者における肝線維症の非侵襲的バイオマーカーとして機能する可能性がある

Plasma eicosanoids as noninvasive biomarkers of liver fibrosis in patients with nonalcoholic steatohepatitis.
  • Cyrielle Caussy
  • Jen-Chieh Chuang
  • Andrew Billin
  • Tao Hu
  • Ya Wang
  • G Mani Subramanian
  • C Stephen Djedjos
  • Robert P Myers
  • Edward A Dennis
  • Rohit Loomba
  • Therap Adv Gastroenterol.2020;13:1756284820923904. 10.1177_1756284820923904. doi: 10.1177/1756284820923904.Epub 2020-05-26.

妊娠糖尿病のスクリーニングおよび診断検査としてのヘモグロビンA1cの精度：検査精度に関する研究のシステマティックレビューとメタアナリシス

The accuracy of haemoglobin A1c as a screening and diagnostic test for gestational diabetes: a systematic review and meta-analysis of test accuracy studies.
  • Chiamaka Esther Amaefule
  • Archana Sasitharan
  • Princee Kalra
  • Stamatina Iliodromoti
  • Mohammed S B Huda
  • Ewelina Rogozinska
  • Javier Zamora
  • Shakila Thangaratinam
  • Curr. Opin. Obstet. Gynecol..2020 Jun;doi: 10.1097/GCO.0000000000000648.Epub 2020-06-28.

定量的プロテオームプロファイリングにより、糸状菌のリグノセルラーゼ産生応答のためのセロビオース依存性のタンパク質処理と輸出経路を明らかにした

Quantitative proteome profiling reveals cellobiose-dependent protein processing and export pathways for the lignocellulolytic responses in .
  • Dan Liu
  • Yisong Liu
  • Duoduo Zhang
  • Xiaoting Chen
  • Qian Liu
  • Bentao Xiong
  • Lihui Zhang
  • Linfang Wei
  • Yifan Wang
  • Hao Fang
  • Johannes Liesche
  • Yahong Wei
  • N Louise Glass
  • Zhiqi Hao
  • Shaolin Chen
  • Appl. Environ. Microbiol..2020 May;AEM.00653-20. doi: 10.1128/AEM.00653-20.Epub 2020-05-29.

ラパマイシンはオートファジーフラックスの回復と小胞体ストレスの抑制を介して、高トリグリセリド血症に伴う急性膵炎を緩和する

Rapamycin Alleviates Hypertriglyceridemia-Related Acute Pancreatitis via Restoring Autophagy Flux and Inhibiting Endoplasmic Reticulum Stress.
  • Qixiang Mei
  • Yue Zeng
  • Chunlan Huang
  • Junyuan Zheng
  • Yuecheng Guo
  • Junjie Fan
  • Xinyuan Fu
  • Xingpeng Wang
  • Yingying Lu
  • Inflammation.2020 Jul;10.1007/s10753-020-01228-7. doi: 10.1007/s10753-020-01228-7.Epub 2020-07-09.

COVID-19パンデミックとの戦いに向けた統合科学の急務

The urgent need for integrated science to fight COVID-19 pandemic and beyond.
  • Negar Moradian
  • Hans D Ochs
  • Constantine Sedikies
  • Michael R Hamblin
  • Carlos A Camargo
  • J Alfredo Martinez
  • Jacob D Biamonte
  • Mohammad Abdollahi
  • Pedro J Torres
  • Juan J Nieto
  • Shuji Ogino
  • John F Seymour
  • Ajith Abraham
  • Valentina Cauda
  • Sudhir Gupta
  • Seeram Ramakrishna
  • Frank W Sellke
  • Armin Sorooshian
  • A Wallace Hayes
  • Maria Martinez-Urbistondo
  • Manoj Gupta
  • Leila Azadbakht
  • Ahmad Esmaillzadeh
  • Roya Kelishadi
  • Alireza Esteghamati
  • Zahra Emam-Djomeh
  • Reza Majdzadeh
  • Partha Palit
  • Hamid Badali
  • Idupulapati Rao
  • Ali Akbar Saboury
  • L Jagan Mohan Rao
  • Hamid Ahmadieh
  • Ali Montazeri
  • Gian Paolo Fadini
  • Daniel Pauly
  • Sabu Thomas
  • Ali A Moosavi-Movahed
  • Asghar Aghamohammadi
  • Mehrdad Behmanesh
  • Vafa Rahimi-Movaghar
  • Saeid Ghavami
  • Roxana Mehran
  • Lucina Q Uddin
  • Matthias Von Herrath
  • Bahram Mobasher
  • Nima Rezaei
  • J Transl Med.2020 05;18(1):205. 10.1186/s12967-020-02364-2. doi: 10.1186/s12967-020-02364-2.Epub 2020-05-19.

TFOS欧州大使会議。眼表面疾患に対する未解決のニーズと将来の科学的・臨床的解決策

TFOS European ambassador meeting: Unmet needs and future scientific and clinical solutions for ocular surface diseases.
  • Susan Erickson
  • Amy Gallant Sullivan
  • Stefano Barabino
  • Enesa Begovic
  • Jose M Benitez-Del-Castillo
  • Stefano Bonini
  • José Salgado Borges
  • Vladimir Brzheskiy
  • Nina Bulat
  • Alma Cerim
  • P Craig
  • Valeriu Cușnir
  • Valeriu Cușnir
  • Vitalie Cușnir
  • Serge Doan
  • Erol Dülger
  • Sarah Farrant
  • Gerd Geerling
  • David Goldblum
  • Sergey Golubev
  • José A P Gomes
  • José Manuel González-Méijome
  • Christina N Grupcheva
  • Ömür Uçakhan Gündüz
  • Jutta Horwath-Winter
  • Fredrik Källmark
  • Nino Karanadze
  • Huda Hajjir Karcic
  • Suvad Karcic
  • Georgios Kontadakis
  • Elisabeth M Messmer
  • Malgorzata Mrugacz
  • Conor Murphy
  • Olivia E O'Leary
  • Vitalie Procopciuc
  • Heiko Pult
  • Peter Raus
  • Afsun Şahin
  • Niko Setälä
  • Adriana Stanila
  • Dan Mircea Stanila
  • Tor Paaske Utheim
  • Jelle Vehof
  • Piera Versura
  • Edoardo Villani
  • Mark D P Willcox
  • James S Wolffsohn
  • Zbigniew Zagórski
  • Gunnar Már Zoega
  • David A Sullivan
  • José A P Gomes
  • Piera Versura
  • Mark D P Willcox
  • Ocul Surf.2020 Jun;S1542-0124(20)30084-7. doi: 10.1016/j.jtos.2020.05.006.Epub 2020-06-03.

合成または複製：サンプリング方法とプロトコルの違いが、収集した渓流無脊椎動物および関連するバイオアセスメント指標をどのように変化させるか

To composite or replicate: how sampling method and protocol differences alter collected stream invertebrates and associated bioassessment metrics.
  • Lusha Tronstad
  • Oliver Wilmot
  • Darren Thornbrugh
  • Scott Hotaling
  • Environ Monit Assess.2020 Jul;192(8):531. 10.1007/s10661-020-08489-7. doi: 10.1007/s10661-020-08489-7.Epub 2020-07-18.

気候主導の大西洋ハリケーンとCOVID-19の伝播という双子の脅威を緩和すること

Mitigating the twin threats of climate-driven Atlantic hurricanes and COVID-19 transmission.
  • James M Shultz
  • James P Kossin
  • Attila J Hertelendy
  • Fredrick Burkle
  • Craig Fugate
  • Ronald Sherman
  • Johnna Bakalar
  • Kim Berg
  • Alessandra Maggioni
  • Zelde Espinel
  • Duane E Sands
  • Regina C LaRocque
  • Renee N Salas
  • Sandro Galea
  • Disaster Med Public Health Prep.2020 Jul;:1-30. S1935789320002438. doi: 10.1017/dmp.2020.243.Epub 2020-07-14.

マウスの三叉神経中枢系へのビブリッサルーディメントの特異的に局在した手がかりを伝達するための濾胞神経の差異的な fasciculation（DiIおよびDiAラベリングを用いて開発された）

Differential fasciculation of follicular nerves for transferring specifically localized cues of the vibrissa rudiments to the central trigeminal sensory system in mice, as exploited with DiI and DiA labeling.
  • M Yamakado
  • K Honzawa
  • H Tsuchiya
  • Kaibogaku Zasshi.1998 Jun;73(3):209-21.

に対して有効なのはバルネムリンだけであった．多剤耐性株の2つのグループが優勢で、1つはフルオロキノロン系抗菌薬に感受性を示す

in Spanish Cattle Herds: Two Groups of Multiresistant Isolates Predominate, with One Remaining Susceptible to Fluoroquinolones.
  • Ana García-Galán
  • Laurent-Xavier Nouvel
  • Eric Baranowski
  • Ángel Gómez-Martín
  • Antonio Sánchez
  • Christine Citti
  • Christian de la Fe
  • Pathogens.2020 Jul;9(7). E545. doi: 10.3390/pathogens9070545.Epub 2020-07-07.

解糖・グルコース新生-トリカルボン酸サイクル関連代謝物、地中海式食事療法、2型糖尿病

Glycolysis/gluconeogenesis- and tricarboxylic acid cycle-related metabolites, Mediterranean diet, and type 2 diabetes.
  • Marta Guasch-Ferré
  • José L Santos
  • Miguel A Martínez-González
  • Clary B Clish
  • Cristina Razquin
  • Dong Wang
  • Liming Liang
  • Jun Li
  • Courtney Dennis
  • Dolores Corella
  • Carlos Muñoz-Bravo
  • Dora Romaguera
  • Ramón Estruch
  • José Manuel Santos-Lozano
  • Olga Castañer
  • Angel Alonso-Gómez
  • Luis Serra-Majem
  • Emilio Ros
  • Sílvia Canudas
  • Eva M Asensio
  • Montserrat Fitó
  • Kerry Pierce
  • J Alfredo Martínez
  • Jordi Salas-Salvadó
  • Estefanía Toledo
  • Frank B Hu
  • Miguel Ruiz-Canela
  • Am. J. Clin. Nutr..2020 04;111(4):835-844. 5736352. doi: 10.1093/ajcn/nqaa016.

成人重症再生不良性貧血患者における無血幹細胞移植とハプイチデンタル幹細胞移植の比較検討

Comparable Outcomes Between Unrelated and Haploidentical Stem Cell Transplantation in Adult Patients With Severe Aplastic Anemia.
  • Sung-Soo Park
  • Gi June Min
  • Silvia Park
  • Sung-Eun Lee
  • Jae-Ho Yoon
  • Seung Hwan Shin
  • Byung-Sik Cho
  • Ki-Seong Eom
  • Yoo-Jin Kim
  • Seok Lee
  • Chang-Ki Min
  • Hee-Je Kim
  • Seok-Goo Cho
  • Jong Wook Lee
  • Transplantation.2020 Jun;doi: 10.1097/TP.0000000000003342.Epub 2020-06-29.

ホスホジエステラーゼ2Aのポジトロン断層撮影法によるイメージングのための新規フッ素18標識ベンゾイミダゾトリアジン系ラジオリガンドの合成と生物学的研究

Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine- Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography.
  • Rien Ritawidya
  • Barbara Wenzel
  • Rodrigo Teodoro
  • Magali Toussaint
  • Mathias Kranz
  • Winnie Deuther-Conrad
  • Sladjana Dukic-Stefanovic
  • Friedrich-Alexander Ludwig
  • Matthias Scheunemann
  • Peter Brust
  • Molecules.2019 Nov;24(22). E4149. doi: 10.3390/molecules24224149.Epub 2019-11-15.

熱可塑性ネットワークを有するポリ(プロピレンカーボネート)の強化。CO/PO共重合における無水マレイン酸オリゴマーの架橋役割

Enhanced Poly(propylene carbonate) with Thermoplastic Networks: A Cross-Linking Role of Maleic Anhydride Oligomer in CO/PO Copolymerization.
  • Lijun Gao
  • Meiying Huang
  • Qifeng Wu
  • Xiaodan Wan
  • Xiaodi Chen
  • Xinxin Wei
  • Wenjing Yang
  • Rule Deng
  • Lingyun Wang
  • Jiuying Feng
  • Polymers (Basel).2019 Sep;11(9). E1467. doi: 10.3390/polym11091467.Epub 2019-09-08.

カテリシジンウシミエロイド抗菌ペプチド（ＢＭＡＰ）２８は、ウシ神経系におけるα型ヘルペスウイルスに対する炎症反応に関与している

Cathelicidin bovine myeloid antimicrobial peptide (BMAP) 28 is involved in the inflammatory response against alpha-herpesviruses in the bovine nervous system.
  • M M Burucúa
  • S E Pérez
  • A C Odeón
  • E R Cobo
  • S Quintana
  • M S Marin
  • Mol. Immunol..2020 Apr;122:148-155. S0161-5890(20)30162-0. doi: 10.1016/j.molimm.2020.04.017.Epub 2020-04-30.

心代謝の健康、血管機能、およびエンドカンナビノイド、PREVIEW研究上の高タンパク食の効果

Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids-A PREVIEW Study.
  • Lea Tischmann
  • Mathijs Drummen
  • Peter J Joris
  • Blandine Gatta-Cherifi
  • Anne Raben
  • Mikael Fogelholm
  • Isabelle Matias
  • Daniela Cota
  • Ronald P Mensink
  • Margriet S Westerterp-Plantenga
  • Tanja C Adam
  • Nutrients.2020 May;12(5). E1512. doi: 10.3390/nu12051512.Epub 2020-05-22.

ホスホジエステラーゼ-5阻害剤（クエン酸シルデナフィル）がラットの一部の海馬神経伝達物質、酸化ストレス状態、ミネラル、不安様行動に与える影響

The impact of phosphodiesterase-5 inhibitor (sildenafil citrate) on some hippocampal neurotransmitters, oxidative stress status, minerals, and anxiety-like behavior in rats.
  • Mona Hafez Hafez
  • Sara Elsayed El-Kazaz
  • J Adv Vet Anim Res.2020 Jun;7(2):281-289. doi: 10.5455/javar.2020.g419.Epub 2020-04-24.

テディゾリドの嫌気性菌332株に対するin vitro活性は，リネゾリドおよび他の5つの抗菌薬と比較して，群菌，群菌，群菌，群菌を含む嫌気性菌332株を対象としたものである

The in vitro activity of tedizolid compared to linezolid and five other antimicrobial agents against 332 anaerobic isolates including group spp., , and spp.
  • Ellie J C Goldstein
  • C Vreni Merriam
  • Diane M Citron
  • Antimicrob. Agents Chemother..2020 Jul;AAC.01088-20. doi: 10.1128/AAC.01088-20.Epub 2020-07-06.

トコトリエノールを豊富に含むビタミンE（トコビッド）の糖尿病性神経障害に対する効果。A Phase II Randomized Controlled Trial

The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetic Neuropathy: A Phase II Randomized Controlled Trial.
  • Yeek Tat Ng
  • Sonia Chew Wen Phang
  • Gerald Chen Jie Tan
  • En Yng Ng
  • Nevein Philip Botross Henien
  • Uma Devi M Palanisamy
  • Badariah Ahmad
  • Khalid Abdul Kadir
  • Nutrients.2020 May;12(5). E1522. doi: 10.3390/nu12051522.Epub 2020-05-23.

ウガンダ、ラカイの女性におけるHIV-1潜伏リザーバーの増殖の減少と明確な免疫相関

Reduced HIV-1 latent reservoir outgrowth and distinct immune correlates among females in Rakai, Uganda.
  • Jessica L Prodger
  • Adam A Capoferri
  • Katherine Yu
  • Jun Lai
  • Steven J Reynolds
  • Jingo Kasule
  • Taddeo Kityamuweesi
  • Paul Buule
  • David Serwadda
  • Kyungyoon J Kwon
  • Katherine Schlusser
  • Craig Martens
  • Eileen P Scully
  • Yun-Hee Choi
  • Andrew D Redd
  • Thomas C Quinn
  • JCI Insight.2020 Jun;139287. doi: 10.1172/jci.insight.139287.Epub 2020-06-16.

クエルセチンとクルクミンの相乗効果による乳がん細胞のアポトーシス抑制効果

Efficient synergistic combination effect of Quercetin with Curcumin on breast cancer cell apoptosis through their loading into Apo ferritin cavity.
  • Fariba Mansourizadeh
  • Diego Alberti
  • Valeria Bitonto
  • Martina Tripepi
  • Houri Sepehri
  • Sepideh Khoee
  • Simonetta Geninatti Crich
  • Colloids Surf B Biointerfaces.2020 Jul;191:110982. S0927-7765(20)30212-5. doi: 10.1016/j.colsurfb.2020.110982.Epub 2020-03-19.

刺激応答性眼球ゲンタマイシン-フェリングキトサンナノ粒子ヒドロゲル：製剤化の最適化、眼の安全性と抗菌性の評価

Stimulus Responsive Ocular Gentamycin-Ferrying Chitosan Nanoparticles Hydrogel: Formulation Optimization, Ocular Safety and Antibacterial Assessment.
  • Nabil K Alruwaili
  • Ameeduzzafar Zafar
  • Syed Sarim Imam
  • Khalid Saad Alharbi
  • Nasser Hadal Alotaibi
  • Sultan Alshehri
  • Nabil A Alhakamy
  • Abdulaziz I Alzarea
  • Muhammad Afzal
  • Mohammed Elmowafy
  • Int J Nanomedicine.2020;15:4717-4737. 254763. doi: 10.2147/IJN.S254763.Epub 2020-06-30.

細菌の細胞増殖は、蛍光顕微鏡観察中にバイオレット光とブルーライトでは抑制されるが、イエローライトでは抑制されないことを示した

Bacterial cell growth is arrested by violet and blue, but not yellow light excitation during fluorescence microscopy.
  • Nina El Najjar
  • Muriel C F van Teeseling
  • Benjamin Mayer
  • Silke Hermann
  • Martin Thanbichler
  • Peter L Graumann
  • BMC Mol Cell Biol.2020 May;21(1):35. 10.1186/s12860-020-00277-y. doi: 10.1186/s12860-020-00277-y.Epub 2020-05-01.

リピドミクスとターゲットメタボロミクスの統合解析により、去勢した子羊の大腰筋における風味前駆体の変化が明らかになりました

Integrated lipidomics and targeted metabolomics analyses reveal changes in flavor precursors in psoas major muscle of castrated lambs.
  • Jing Li
  • Chaohua Tang
  • Qingyu Zhao
  • Yuanyuan Yang
  • Fadi Li
  • Yuchang Qin
  • Xiaohui Liu
  • Xiangpeng Yue
  • Junmin Zhang
  • Food Chem.2020 Jul;333:127451. S0308-8146(20)31313-3. doi: 10.1016/j.foodchem.2020.127451.Epub 2020-07-05.

Caulobacter crescentusにおける細菌の細胞極安定化の喪失は、外膜ストレスとペプチドグリカン指向性抗生物質に敏感になる

Loss of Bacterial Cell Pole Stabilization in Caulobacter crescentus Sensitizes to Outer Membrane Stress and Peptidoglycan-Directed Antibiotics.
  • Simon-Ulysse Vallet
  • Lykke Haastrup Hansen
  • Freja Cecillie Bistrup
  • Signe Aagaard Laursen
  • Julien Bortoli Chapalay
  • Marc Chambon
  • Gerardo Turcatti
  • Patrick H Viollier
  • Clare L Kirkpatrick
  • mBio.2020 May;11(3). e00538-20. doi: 10.1128/mBio.00538-20.Epub 2020-05-05.

先祖代々の遺伝子の再構築と生化学的特徴付けは、イネ科におけるテルペン合成酵素機能の進化についての洞察を与えてくれる

The reconstruction and biochemical characterization of ancestral genes furnish insights into the evolution of terpene synthase function in the Poaceae.
  • Katrin Luck
  • Xinlu Chen
  • Ayla M Norris
  • Feng Chen
  • Jonathan Gershenzon
  • Tobias G Köllner
  • Plant Mol. Biol..2020 Jul;10.1007/s11103-020-01037-4. doi: 10.1007/s11103-020-01037-4.Epub 2020-07-18.

新生児/小児集中治療室における診断ツールとしての全ゲノム迅速シークエンシング

Rapid Whole-Exome Sequencing as a Diagnostic Tool in a Neonatal/Pediatric Intensive Care Unit.
  • Robert Śmigiel
  • Mateusz Biela
  • Krzysztof Szmyd
  • Michal Błoch
  • Elżbieta Szmida
  • Paweł Skiba
  • Anna Walczak
  • Piotr Gasperowicz
  • Joanna Kosińska
  • Małgorzata Rydzanicz
  • Piotr Stawiński
  • Anna Biernacka
  • Marzena Zielińska
  • Waldemar Gołębiowski
  • Agnieszka Jalowska
  • Grażyna Ohia
  • Bożena Głowska
  • Wojciech Walas
  • Barbara Królak-Olejnik
  • Paweł Krajewski
  • Jolanta Sykut-Cegielska
  • Maria M Sąsiadek
  • Rafał Płoski
  • J Clin Med.2020 Jul;9(7). E2220. doi: 10.3390/jcm9072220.Epub 2020-07-13.

C. crescentus xynA2 遺伝子のクローニング、発現および特性評価、および植物バイオマスの分解におけるキシラナーゼIIの応用

Cloning, expression and characterization of C. crescentus xynA2 gene and application of Xylanase II in the deconstruction of plant biomass.
  • Débora Jacomini
  • Larissa Bussler
  • Juliana Moço Corrêa
  • Marina Kimiko Kadowaki
  • Alexandre Maller
  • José Luis da-Conceição Silva
  • Rita de Cássia Garcia Simão
  • Mol. Biol. Rep..2020 Jun;47(6):4427-4438. 10.1007/s11033-020-05507-2. doi: 10.1007/s11033-020-05507-2.Epub 2020-05-18.

アヒルIgY FcとSchisandra chinensis多糖類アジュバントを融合させたRiemerella anatipestifer OmpAの組換えワクチンは、防御免疫応答を向上させる

A recombinant vaccine of Riemerella anatipestifer OmpA fused with duck IgY Fc and Schisandra chinensis polysaccharide adjuvant enhance protective immune response.
  • Shifa Yang
  • Wenwen Dong
  • Guiming Li
  • Zengcheng Zhao
  • Minxun Song
  • Zhongli Huang
  • Jian Fu
  • Fengjuan Jia
  • Shuqian Lin
  • Microb. Pathog..2019 Nov;136:103707. S0882-4010(19)30296-7. doi: 10.1016/j.micpath.2019.103707.Epub 2019-09-03.

カルシトニン遺伝子関連ペプチドおよびアドレノメデュリン受容体へのGタンパク質のカップリングの生化学的特徴付けをネイティブPAGEアッセイを用いて行った

Biochemical characterization of G protein coupling to calcitonin gene-related peptide and adrenomedullin receptors using a native PAGE assay.
  • Amanda M Roehrkasse
  • Margaret L Warner
  • Jason M Booe
  • Augen A Pioszak
  • J. Biol. Chem..2020 Jul;295(28):9736-9751. RA120.013854. doi: 10.1074/jbc.RA120.013854.Epub 2020-06-02.

Corynebacterium glutamicumにおけるキシロースからキシロン酸へのバイオ変換遺伝子の異種発現とバイオプロセスの最適化

Heterologous expression of genes for bioconversion of xylose to xylonic acid in Corynebacterium glutamicum and optimization of the bioprocess.
  • M S Lekshmi Sundar
  • Aliyath Susmitha
  • Devi Rajan
  • Silvin Hannibal
  • Keerthi Sasikumar
  • Volker F Wendisch
  • K Madhavan Nampoothiri
  • AMB Express.2020 Apr;10(1):68. 10.1186/s13568-020-01003-9. doi: 10.1186/s13568-020-01003-9.Epub 2020-04-15.

確率的学習と反転時の注意力測定に及ぼす慢性的な断続的自発的アルコール消費の性依存性効果

Sex-dependent effects of chronic intermittent voluntary alcohol consumption on attentional, not motivational, measures during probabilistic learning and reversal.
  • Claudia G Aguirre
  • Alexandra Stolyarova
  • Kanak Das
  • Saisriya Kolli
  • Vincent Marty
  • Lara Ray
  • Igor Spigelman
  • Alicia Izquierdo
  • PLoS ONE.2020;15(6):e0234729. PONE-D-19-33516. doi: 10.1371/journal.pone.0234729.Epub 2020-06-18.

耳石経路を伴う核前神経障害を伴う先天性第三頭蓋神経麻痺。先天性第三頭蓋神経麻痺の根底には、新しい先天性頭蓋神経障害が存在する

Congenital third cranial nerve palsy with prenuclear dysinnervation involving otolithic pathways: Underpinnings of a novel congenital cranial dysinnervation disorder.
  • Pramod K Pandey
  • Divya Kishore
  • Annu Joon
  • Priya Saraf
  • Indian J Ophthalmol.2020 Jul;68(7):1478-1480. IndianJOphthalmol_2020_68_7_1478_287503. doi: 10.4103/ijo.IJO_1627_19.

食道内視鏡的粘膜下層剥離術後の狭窄予防としてのステロイド注射とポリグリコール酸遮蔽：レトロスペクティブな比較分析

Steroid injection and polyglycolic acid shielding as a prevention against stricture after esophageal endoscopic submucosal dissection: a retrospective comparative analysis.
  • Yoshiki Sakaguchi
  • Yosuke Tsuji
  • Tomohiro Shinozaki
  • Daisuke Ohki
  • Hiroya Mizutani
  • Chihiro Minatsuki
  • Keiko Niimi
  • Nobutake Yamamichi
  • Kazuhiko Koike
  • Gastrointest. Endosc..2020 May;S0016-5107(20)34270-X. doi: 10.1016/j.gie.2020.04.070.Epub 2020-05-03.

運動時の体温上昇は、2型糖尿病ラットの骨格筋におけるAktシグナル伝達経路の活性化に不可欠である

Body temperature elevation during exercise is essential for activating the Akt signaling pathway in the skeletal muscle of type 2 diabetic rats.
  • Takamasa Tsuzuki
  • Toshinori Yoshihara
  • Noriko Ichinoseki-Sekine
  • Ryo Kakigi
  • Yuri Takamine
  • Hiroyuki Kobayashi
  • Hisashi Naito
  • PLoS ONE.2018;13(10):e0205456. PONE-D-18-18834. doi: 10.1371/journal.pone.0205456.Epub 2018-10-10.

NSAID増悪性呼吸器疾患における炎症性マクロファージの記憶

Inflammatory macrophage memory in NSAID-exacerbated respiratory disease.
  • Pascal Haimerl
  • Ulrike Bernhardt
  • Sonja Schindela
  • Fiona Dr Henkel
  • Antonie Lechner
  • Ulrich M Zissler
  • Xavier Pastor
  • Dominique Thomas
  • Alexander Cecil
  • Yan Ge
  • Mark Haid
  • Cornelia Prehn
  • Janina Tokarz
  • Matthias Heinig
  • Jerzy Adamski
  • Carsten B Schmidt-Weber
  • Adam M Chaker
  • Julia Esser-von Bieren
  • J. Allergy Clin. Immunol..2020 Jun;S0091-6749(20)30803-4. doi: 10.1016/j.jaci.2020.04.064.Epub 2020-06-12.

コアシェルポリ(D,l-ラクチド-コ-グリコリド)-キトサンナノスフェアとシムバスタチン-ドキシサイクリンを用いた歯周および骨修復のためのコアシェルキトサンナノスフェア

Core-Shell poly-(D,l-Lactide-co-Glycolide)-chitosan Nanospheres with simvastatin-doxycycline for periodontal and osseous repair.
  • Po-Chun Chang
  • Wei-Chiu Tai
  • Hui-Ting Luo
  • Chern-Hsiung Lai
  • Hsu-Hsiang Lin
  • Zhi-Jie Lin
  • Ying-Chieh Chang
  • Bor-Shiunn Lee
  • Int. J. Biol. Macromol..2020 May;158:627-635. S0141-8130(20)33043-9. doi: 10.1016/j.ijbiomac.2020.04.183.Epub 2020-05-07.

Ad5 ベクター化 HIV ワクチン接種者における粘膜 T 細胞の長期的な活性化とホーミング表現型

Long-term mucosal T cell activation and homing phenotypes in recipients of an Ad5-vectored HIV vaccine.
  • Marcel E Curlin
  • Jason Shao
  • Gabriela Diaz
  • Paul T Edlefsen
  • Richard M Novak
  • Kenneth H Mayer
  • Mary Allen
  • Cecilia Morgan
  • Janine Maenza
  • Susan Buchbinder
  • Michael C Keefer
  • Stephen C De Rosa
  • Lawrence Corey
  • Ann Duerr
  • Vaccine.2020 Jul;S0264-410X(20)30829-X. doi: 10.1016/j.vaccine.2020.06.043.Epub 2020-07-14.

ネオアジュバント化学療法後の乳癌における腋窩ステージングの問題点。標的腋窩郭清の役割とリンパ節マーカーの種類

The problem of axillary staging in breast cancer after neoadjuvant chemotherapy. Role of targeted axillary dissection and types of lymph node markers.
  • Diego Flores-Funes
  • José Aguilar-Jiménez
  • María Martínez-Gálvez
  • María José Ibáñez-Ibáñez
  • Luis Carrasco-González
  • José Ignacio Gil-Izquierdo
  • José Luis Aguayo-Albasini
  • Cir Esp.2020 May;S0009-739X(20)30097-X. doi: 10.1016/j.ciresp.2020.03.012.Epub 2020-05-05.

電気熱原子吸光分析法を用いた液相マイクロ抽出をベースとした環境に優しい超音波支援型深層共晶溶媒による水中および生物学的試料中の水銀のスペシエーション

Speciation of mercury in water and biological samples by eco-friendly ultrasound-assisted deep eutectic solvent based on liquid phase microextraction with electrothermal atomic absorption spectrometry.
  • Arnon Thongsaw
  • Yuthapong Udnan
  • Gareth M Ross
  • Wipharat Chuachuad Chaiyasith
  • Talanta.2019 May;197:310-318. S0039-9140(19)30018-9. doi: 10.1016/j.talanta.2019.01.018.Epub 2019-01-09.

三酸化ヒ素はインターフェロン阻害を介して形質細胞性樹状細胞の調節機能を誘導する

Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- inhibition.
  • Yishan Ye
  • Laure Ricard
  • Lama Siblany
  • Nicolas Stocker
  • Frédéric De Vassoigne
  • Eolia Brissot
  • Baptiste Lamarthée
  • Arsène Mekinian
  • Mohamad Mohty
  • Béatrice Gaugler
  • Florent Malard
  • Acta Pharm Sin B.2020 Jun;10(6):1061-1072. S2211-3835(19)30954-2. doi: 10.1016/j.apsb.2020.01.016.Epub 2020-01-31.

HNF1A糖尿病（3型若年者の成熟期糖尿病）患者におけるリナグリプチン治療の有無にかかわらずグリメピリドの有効性と安全性。A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA)

Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA).
  • Alexander S Christensen
  • Sofie Hædersdal
  • Julie Støy
  • Heidi Storgaard
  • Ulla Kampmann
  • Julie L Forman
  • Marta Seghieri
  • Jens J Holst
  • Torben Hansen
  • Filip K Knop
  • Tina Vilsbøll
  • Diabetes Care.2020 Jul;dc200408. doi: 10.2337/dc20-0408.Epub 2020-07-13.

メンサピペリタ精油への連続暴露は、持続的に流行するサルモネラ菌PT4の培養性に影響を与え、膜修復を誘導することがわかった

Successive exposure to Mentha piperita L. essential oil affects the culturability and induces membrane repair in a persister epidemic Salmonella Typhimurium PT4.
  • Adma Nadja Ferreira de Melo
  • Geany Targino de Souza Pedrosa
  • Erika Tayse da Cruz Almeida
  • Guojie Cao
  • Dumitru Macarisin
  • Donald W Schaffner
  • Evandro L de Souza
  • Marciane Magnani
  • Microb. Pathog..2020 May;149:104264. S0882-4010(20)30630-6. doi: 10.1016/j.micpath.2020.104264.Epub 2020-05-25.

花粉がインフルエンザ様の流行を抑制する季節的要因と思われる花粉の数と花粉症とインフルエンザ様発症率の逆関係を調べたオランダの研究 2016-2019年

Pollen likely seasonal factor in inhibiting flu-like epidemics. A Dutch study into the inverse relation between pollen counts, hay fever and flu-like incidence 2016-2019.
  • Martijn J Hoogeveen
  • Sci. Total Environ..2020 Jul;727:138543. S0048-9697(20)32056-8. doi: 10.1016/j.scitotenv.2020.138543.Epub 2020-04-17.

モリンガオレイフェラ茎（MOS）加工飼料を給与した場合の産卵鴨の成長・産卵成績および免疫・抗酸化活性に及ぼす影響

Effects of feeding diets with processed Moringa oleifera stem meal on growth and laying performance, and immunological and antioxidant activities in laying ducks.
  • S L Yang
  • R C Yang
  • X Zhou
  • S H Yang
  • L L Luo
  • Y C Zhu
  • Surintorn Boonanuntan
  • Poult. Sci..2020 Jul;99(7):3445-3451. S0032-5791(20)30238-8. doi: 10.1016/j.psj.2020.04.002.Epub 2020-04-24.

CFTR補正装置ABBV-2222/GLPG2222によるF508delCFTRタンパク質プロセシングの生物学的特性評価

Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222.
  • Ashvani K Singh
  • Yihong Fan
  • Corina Balut
  • Sara Alani
  • Arlene M Manelli
  • Andrew M Swensen
  • Ying Jia
  • Torben R Neelands
  • Timothy A Vortherms
  • Bo Liu
  • Xenia B Searle
  • Xueqing Wang
  • Wenqing Gao
  • Tzyh-Chang Hwang
  • Hong Y Ren
  • Douglas Cyr
  • Philip R Kym
  • Katja Conrath
  • Chris Tse
  • J. Pharmacol. Exp. Ther..2020 01;372(1):107-118. jpet.119.261800. doi: 10.1124/jpet.119.261800.Epub 2019-11-15.

妊娠中の食事因子と小児期のアトピーの転帰：アレルギーと臨床免疫学の欧州アカデミーからの系統的レビュー

Dietary factors during pregnancy and atopic outcomes in childhood: a systematic review from the European Academy of Allergy and Clinical Immunology.
  • C Venter
  • C Agostoni
  • S H Arshad
  • M Ben-Abdallah
  • G Du Toit
  • D M Fleischer
  • M Greenhawt
  • D H Glueck
  • M Groetch
  • N Lunjani
  • K Maslin
  • A Maiorella
  • R Meyer
  • A Muraro
  • M J Netting
  • B I Nwaru
  • D J Palmer
  • M P Palumbo
  • G Roberts
  • C Roduit
  • P K Smith
  • E Untersmayr
  • L Vanderlinden
  • L O'Mahony
  • Pediatr Allergy Immunol.2020 Jun;doi: 10.1111/pai.13303.Epub 2020-06-10.

漢方薬Radix Paeoniae Rubraがアラキドン酸経路のPTGS2を調節して慢性骨盤内炎症疾患を改善するメカニズムの研究

Research on the mechanism of Chinese herbal medicine Radix Paeoniae Rubra in improving chronic pelvic inflammation disease by regulating PTGS2 in the arachidonic acid pathway.
  • Xiao-Hong Li
  • Yan-Ru Liu
  • Da-Hai Jiang
  • Zhi-Shu Tang
  • Da-Wei Qian
  • Zhong-Xing Song
  • Lin Chen
  • Xin-Bo Shi
  • Ning-Juan Yang
  • Ya-Feng Yan
  • Ai-Bing Chang
  • Biomed. Pharmacother..2020 Jun;129:110052. S0753-3322(20)30243-2. doi: 10.1016/j.biopha.2020.110052.Epub 2020-06-16.

心房間ブロック、左房線維症、機械的同期不全との関連性：心電図と磁気共鳴画像の相関

Association between interatrial block, left atrial fibrosis, and mechanical dyssynchrony: Electrocardiography-magnetic resonance imaging correlation.
  • Luisa Ciuffo
  • Vanesa Bruña
  • Manuel Martínez-Sellés
  • Henrique Doria de Vasconcellos
  • Susumu Tao
  • Tarek Zghaib
  • Saman Nazarian
  • David D Spragg
  • Joseph Marine
  • Ronald D Berger
  • Joao A C Lima
  • Hugh Calkins
  • Antonio Bayés-de-Luna
  • Hiroshi Ashikaga
  • J. Cardiovasc. Electrophysiol..2020 Jul;31(7):1719-1725. doi: 10.1111/jce.14608.Epub 2020-06-15.

悪性胸膜中皮腫におけるBAP-1免疫組織化学の予後的役割を問う。システマティックレビューとメタアナリシスを用いた単一施設の経験

Questioning the prognostic role of BAP-1 immunohistochemistry in malignant pleural mesothelioma: A single center experience with systematic review and meta-analysis.
  • Luca Cantini
  • Federica Pecci
  • Alberto Murrone
  • Marco Tomasetti
  • Cecilia Copparoni
  • Ilaria Fiordoliva
  • Francesca Morgese
  • Silvia Rinaldi
  • Paola Mazzanti
  • Corrado Rubini
  • Alessia Cimadamore
  • Francesca Barbisan
  • Riccardo Giampieri
  • Marina Scarpelli
  • Lory Santarelli
  • Rossana Berardi
  • Lung Cancer.2020 Aug;146:318-326. S0169-5002(20)30498-0. doi: 10.1016/j.lungcan.2020.06.024.Epub 2020-06-21.

G3BPの分離ドメインは、アルファウイルス複製複合体の効率的なクラスタリングと翻訳開始機構のリクルートを促進する

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.
  • Benjamin Götte
  • Marc D Panas
  • Kirsi Hellström
  • Lifeng Liu
  • Baila Samreen
  • Ola Larsson
  • Tero Ahola
  • Gerald M McInerney
  • PLoS Pathog..2019 06;15(6):e1007842. PPATHOGENS-D-19-00011. doi: 10.1371/journal.ppat.1007842.Epub 2019-06-14.

背側根神経節ニューロンのサブクラスの機能分類を容易に行うための統合的アプローチ

An integrative approach to the facile functional classification of dorsal root ganglion neuronal subclasses.
  • Mario J Giacobassi
  • Lee S Leavitt
  • Shrinivasan Raghuraman
  • Rishi Alluri
  • Kevin Chase
  • Rocio K Finol-Urdaneta
  • Heinrich Terlau
  • Russell W Teichert
  • Baldomero M Olivera
  • Proc. Natl. Acad. Sci. U.S.A..2020 03;117(10):5494-5501. 1911382117. doi: 10.1073/pnas.1911382117.Epub 2020-02-20.

患者が他の患者を助ける。孤児院では、「ハンセン病患者が他の患者を助ける」ことを目的とした研究が行われています

Patients help other patients: Qualitative study on a longstanding community cooperative to tackle leprosy in India.
  • Seong Hye Jung
  • Hee Won Han
  • Hyeonseok Koh
  • Soo-Young Yu
  • Nobutoshi Nawa
  • Ayako Morita
  • Ken Ing Cherng Ong
  • Masamine Jimba
  • Juhwan Oh
  • PLoS Negl Trop Dis.2020 01;14(1):e0008016. PNTD-D-19-00319. doi: 10.1371/journal.pntd.0008016.Epub 2020-01-13.

気管支肺胞胆汁酸および炎症性マーカーを測定し、逆流および微小吸引を有する高リスク肺移植患者を同定した

Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration.
  • Chen Yang Kevin Zhang
  • Musawir Ahmed
  • Ella Huszti
  • Liran Levy
  • Sarah E Hunter
  • Kristen M Boonstra
  • Sajad Moshkelgosha
  • Andrew T Sage
  • Sassan Azad
  • Ricardo Zamel
  • Rasheed Ghany
  • Jonathan C Yeung
  • Oscar M Crespin
  • Courtney Frankel
  • Marie Budev
  • Pali Shah
  • John M Reynolds
  • Laurie D Snyder
  • John A Belperio
  • Lianne G Singer
  • S Samuel Weigt
  • Jamie L Todd
  • Scott M Palmer
  • Shaf Keshavjee
  • Tereza Martinu
  • J. Heart Lung Transplant..2020 May;S1053-2498(20)31558-8. doi: 10.1016/j.healun.2020.05.006.Epub 2020-05-19.

肥満者の脂肪組織におけるビタミンD受容体遺伝子発現はmiRNAによって制御され、プロ炎症性サイトカインレベルと相関する

Vitamin D Receptor Gene Expression in Adipose Tissue of Obese Individuals is Regulated by miRNA and Correlates with the Pro-Inflammatory Cytokine Level.
  • Marta Izabela Jonas
  • Alina Kuryłowicz
  • Zbigniew Bartoszewicz
  • Wojciech Lisik
  • Maurycy Jonas
  • Krzysztof Kozniewski
  • Monika Puzianowska-Kuznicka
  • Int J Mol Sci.2019 Oct;20(21). E5272. doi: 10.3390/ijms20215272.Epub 2019-10-24.

FAK活性はプラチナ化学療法に対する本質的および後天的な卵巣癌抵抗性を維持する

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.
  • Carlos J Diaz Osterman
  • Duygu Ozmadenci
  • Elizabeth G Kleinschmidt
  • Kristin N Taylor
  • Allison M Barrie
  • Shulin Jiang
  • Lisa M Bean
  • Florian J Sulzmaier
  • Christine Jean
  • Isabelle Tancioni
  • Kristen Anderson
  • Sean Uryu
  • Edward A Cordasco
  • Jian Li
  • Xiao Lei Chen
  • Guo Fu
  • Marjaana Ojalill
  • Pekka Rappu
  • Jyrki Heino
  • Adam M Mark
  • Guorong Xu
  • Kathleen M Fisch
  • Vihren N Kolev
  • David T Weaver
  • Jonathan A Pachter
  • Balázs Győrffy
  • Michael T McHale
  • Denise C Connolly
  • Alfredo Molinolo
  • Dwayne G Stupack
  • David D Schlaepfer
  • Elife.2019 09;8. e47327. doi: 10.7554/eLife.47327.Epub 2019-09-03.

地中海式ダイエットと更年期の健康。EMASのポジションステートメント

The Mediterranean diet and menopausal health: An EMAS position statement.
  • Antonio Cano
  • Skye Marshall
  • Irene Zolfaroli
  • Johannes Bitzer
  • Iuliana Ceausu
  • Peter Chedraui
  • Fatih Durmusoglu
  • Risto Erkkola
  • Dimitrios G Goulis
  • Angelica Lindén Hirschberg
  • Ludwig Kiesel
  • Patrice Lopes
  • Amos Pines
  • Mick van Trotsenburg
  • Irene Lambrinoudaki
  • Margaret Rees
  • Maturitas.2020 Jul;S0378-5122(20)30325-X. doi: 10.1016/j.maturitas.2020.07.001.Epub 2020-07-13.

未治療の濾胞性リンパ腫を対象としたBendamustine/RituximabとBortezomib導入またはLenalidomide継続併用の3アーム無作為化第II相試験。ECOG-ACRIN E2408

A Three-Arm Randomized Phase II Study of Bendamustine/Rituximab with Bortezomib Induction or Lenalidomide Continuation in Untreated Follicular Lymphoma: ECOG-ACRIN E2408.
  • Andrew M Evens
  • Fangxin Hong
  • Thomas M Habermann
  • Ranjana H Advani
  • Randy D Gascoyne
  • Thomas E Witzig
  • Andrew Quon
  • Erik A Ranheim
  • Stephen M Ansell
  • Puneet Singh Cheema
  • Philip A Dy
  • Timothy E O'Brien
  • Jane N Winter
  • Terrence P Cescon
  • Julie E Chang
  • Brad S Kahl
  • Clin. Cancer Res..2020 Jun;1078-0432.CCR-20-1345. doi: 10.1158/1078-0432.CCR-20-1345.Epub 2020-06-12.

常染色体優性多嚢胞性腎疾患における腎予後予測における画像分類に加えて尿中アンジオテンシノーゲン

Urinary Angiotensinogen in addition to Imaging Classification in the Prediction of Renal Outcome in Autosomal Dominant Polycystic Kidney Disease.
  • Hayne Cho Park
  • Juhee Kim
  • AJin Cho
  • Do Hyoung Kim
  • Young Ki Lee
  • Hyunjin Ryu
  • Hyunsuk Kim
  • Kook Hwan Oh
  • Yun Kyu Oh
  • Young Hwan Hwang
  • Kyu Beck Lee
  • Soo Wan Kim
  • Yeong Hoon Kim
  • Joongyub Lee
  • Curie Ahn
  • J. Korean Med. Sci..2020 Jun;35(22):e165. 35.e165. doi: 10.3346/jkms.2020.35.e165.Epub 2020-06-08.

保健システムパフォーマンス評価（IPHA）への人口視点の統合。ドイツにおける横断的研究のための研究プロトコル

Integrating the Population Perspective into Health System Performance Assessment (IPHA): Study Protocol for a Cross-Sectional Study in Germany Linking Survey and Claims Data of Statutorily and Privately Insured.
  • Miriam Blümel
  • Julia Röttger
  • Julia Köppen
  • Katharina Achstetter
  • Reinhard Busse
  • Int J Health Policy Manag.2020 Jan;doi: 10.15171/ijhpm.2019.141.Epub 2020-01-20.

トレーニングによるAT受容体経路の不活性化は、高血圧ラットの高血圧前から高血圧期への移行期に自律神経制御と心臓のリモデリングを促進する

Training-Induced Deactivation of the AT Receptor Pathway Drives Autonomic Control and Heart Remodeling During the Transition From the Pre- to Hypertensive Phase in Spontaneously Hypertensive Rats.
  • Tassia Santos Rodrigues da Costa
  • Gustavo Santos Masson
  • Rosangela Aparecida Dos Santos Eichler
  • Juliane Cristina de Souza Silva
  • Silvia Lacchini
  • Lisete Compagno Michelini
  • Circ. J..2020 Jun;doi: 10.1253/circj.CJ-19-1161.Epub 2020-06-10.

複合飼料を給与した北京ダックの成長成績、枝肉形質、肉質、栄養利用率、アミノ酸の標準化された回腸消化率に及ぼす飼料タンパク質量とプロテアーゼ添加の影響

Effects of dietary protein levels and protease supplementation on growth performance, carcass traits, meat quality, and standardized ileal digestibility of amino acid in Pekin ducks fed a complex diet.
  • Q D Wang
  • K Y Zhang
  • Y Zhang
  • S P Bai
  • X M Ding
  • J P Wang
  • H W Peng
  • G Tian
  • Y Xuan
  • Z W Su
  • Q F Zeng
  • Poult. Sci..2020 Jul;99(7):3557-3566. S0032-5791(20)30223-6. doi: 10.1016/j.psj.2020.03.047.Epub 2020-04-27.

新生児臨床発作に対するレベチラセタムとフェノバルビタールの単剤治療を受けた期の乳児の神経認知転帰の比較

Comparison of the neurocognitive outcomes in term infants treated with levetiracetam and phenobarbital monotherapy for neonatal clinical seizures.
  • Pinar Arican
  • Nihal Olgac Dundar
  • Neslihan Mete Atasever
  • Mine Akkaya Inal
  • Pinar Gencpinar
  • Dilek Cavusoglu
  • Sinem Akbay
  • Hasan Tekgul
  • Seizure.2020 Jun;80:71-74. S1059-1311(20)30168-0. doi: 10.1016/j.seizure.2020.06.006.Epub 2020-06-05.

クロトニル化が重要な代謝酵素のクロトニル化を制御することで、ストレプトミセス・ロゾスポラスの炭素異化抑制が可能になることを明らかにした

Crotonylation of key metabolic enzymes regulates carbon catabolite repression in Streptomyces roseosporus.
  • Chen-Fan Sun
  • Wei-Feng Xu
  • Qing-Wei Zhao
  • Shuai Luo
  • Xin-Ai Chen
  • Yong-Quan Li
  • Xu-Ming Mao
  • Commun Biol.2020 Apr;3(1):192. 10.1038/s42003-020-0924-2. doi: 10.1038/s42003-020-0924-2.Epub 2020-04-24.

HIV-1逆転写酵素は、ツイストの活性酸素依存性アップレギュレーションを介して腫瘍の成長と転移形成を促進する

HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist.
  • Ekaterina Bayurova
  • Juris Jansons
  • Dace Skrastina
  • Olga Smirnova
  • Dzeina Mezale
  • Anastasia Kostyusheva
  • Dmitry Kostyushev
  • Stefan Petkov
  • Philip Podschwadt
  • Vladimir Valuev-Elliston
  • Sviataslau Sasinovich
  • Sergey Korolev
  • Per Warholm
  • Anastasia Latanova
  • Elizaveta Starodubova
  • Amir Tukhvatulin
  • Oleg Latyshev
  • Renat Selimov
  • Pavel Metalnikov
  • Alexander Komarov
  • Olga Ivanova
  • Tatiana Gorodnicheva
  • Sergey Kochetkov
  • Marina Gottikh
  • Ilze Strumfa
  • Alexander Ivanov
  • Ilya Gordeychuk
  • Maria Isaguliants
  • Oxid Med Cell Longev.2019;2019:6016278. doi: 10.1155/2019/6016278.Epub 2019-12-02.

単細胞トランスクリプトミクスを用いた乳がんにおける骨髄由来サプレッサー細胞の出現の定義

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics.
  • Hamad Alshetaiwi
  • Nicholas Pervolarakis
  • Laura Lynn McIntyre
  • Dennis Ma
  • Quy Nguyen
  • Jan Akara Rath
  • Kevin Nee
  • Grace Hernandez
  • Katrina Evans
  • Leona Torosian
  • Anushka Silva
  • Craig Walsh
  • Kai Kessenbrock
  • Sci Immunol.2020 02;5(44). eaay6017. doi: 10.1126/sciimmunol.aay6017.

異化分業は、工学的共培養システムにおけるグルコース-キシロース混合物からのD-乳酸およびコハク酸の生産を向上させる

Catabolic Division of Labor Enhances Production of D-Lactate and Succinate From Glucose-Xylose Mixtures in Engineered Co-culture Systems.
  • Andrew D Flores
  • Hyun G Choi
  • Rodrigo Martinez
  • Moses Onyeabor
  • E Zeynep Ayla
  • Amanda Godar
  • Michael Machas
  • David R Nielsen
  • Xuan Wang
  • Front Bioeng Biotechnol.2020;8:329. doi: 10.3389/fbioe.2020.00329.Epub 2020-05-05.

赤血球AE1/バンド3トランスポートが優性遠位性腎性尿細管アシドーシス患者に認められた

Red Blood Cell AE1/Band 3 Transports in Dominant Distal Renal Tubular Acidosis Patients.
  • Jean-Philippe Bertocchio
  • Sandrine Genetet
  • Lydie Da Costa
  • Stephen B Walsh
  • Bertrand Knebelmann
  • Julie Galimand
  • Lucie Bessenay
  • Corinne Guitton
  • Renaud De Lafaille
  • Rosa Vargas-Poussou
  • Dominique Eladari
  • Isabelle Mouro-Chanteloup
  • Kidney Int Rep.2020 Mar;5(3):348-357. S2468-0249(20)30007-3. doi: 10.1016/j.ekir.2019.12.020.Epub 2020-01-13.

2番染色体2p11.2での再発性微小欠失は、胸腺低形成とDiGeorge症候群に類似した特徴と関連している

Recurrent microdeletions at chromosome 2p11.2 are associated with thymic hypoplasia and features resembling DiGeorge syndrome.
  • Joshua D Bernstock
  • Arthur H Totten
  • Abdel G Elkahloun
  • Kory R Johnson
  • Anna C Hurst
  • Frederick Goldman
  • Andrew K Groves
  • Fady M Mikhail
  • T Prescott Atkinson
  • J. Allergy Clin. Immunol..2020 Jan;145(1):358-367.e2. S0091-6749(19)31256-4. doi: 10.1016/j.jaci.2019.09.020.Epub 2019-10-07.

高分解能質量分析法によるAverrhoa carambola L.樹皮中の二次代謝物の同定とα-グルコシダーゼ、チロシナーゼ、エラスターゼ、抗酸化力の評価

Identification of secondary metabolites in Averrhoa carambola L. bark by high-resolution mass spectrometry and evaluation for α-glucosidase, tyrosinase, elastase, and antioxidant potential.
  • Syful Islam
  • Md Badrul Alam
  • Arif Ahmed
  • Seulgidaun Lee
  • Sang-Han Lee
  • Sunghwan Kim
  • Food Chem.2020 Jun;332:127377. S0308-8146(20)31239-5. doi: 10.1016/j.foodchem.2020.127377.Epub 2020-06-23.

HIV-1サブタイプC逆転写酵素阻害のための天然物スクリーニングのためのシュードウイルスアッセイ法の開発と評価

Development of a pseudovirus assay and evaluation to screen natural products for inhibition of HIV-1 subtype C reverse transcriptase.
  • Lufuno Grace Mavhandu
  • Hua Cheng
  • Yeou-Cheng Bor
  • Denis Manga Tebit
  • Marie-Louise Hammarskjold
  • David Rekosh
  • Pascal Obong Bessong
  • J Ethnopharmacol.2020 Aug;258:112931. S0378-8741(20)30780-7. doi: 10.1016/j.jep.2020.112931.Epub 2020-04-30.

ブラジル，サンパウロの大規模総合病院における定期的なカルテ監査の評価者間の一致度をプロスペクティブに評価したもの．

A prospective evaluation of inter-rater agreement of routine medical records audits at a large general hospital in São Paulo, Brazil.
  • Ana Carolina Cintra Nunes Mafra
  • João Luiz Miraglia
  • Fernando Antonio Basile Colugnati
  • Gilberto Soares Lourenço Padilha
  • Renata Rafaella Santos Tadeucci
  • Ederson Almeida
  • Mario Maia Bracco
  • BMC Health Serv Res.2020 Jul;20(1):638. 10.1186/s12913-020-05495-w. doi: 10.1186/s12913-020-05495-w.Epub 2020-07-10.

菱形脳シナプス症、三叉神経節の突発性および視細胞腫（脱毛症を伴わない）を呈した小児：小脳三叉神経皮膚異形成症の一変か？

A child with rhombencephalosynapsis, agenesis of the trigeminal ganglion and optic coloboma (without alopecia): a variant of the cerebellotrigeminal dermal dysplasia?
  • Federica Sullo
  • Stefano Palmucci
  • Agata Polizzi
  • Martino Ruggieri
  • Andrea D Praticò
  • Clin. Dysmorphol..2020 Jul;doi: 10.1097/MCD.0000000000000333.Epub 2020-07-10.

Klf9 は、グルココルチコイド受容体活性に対するトランスクリプトーム応答を制御する重要なフィードフォワード制御因子である

Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity.
  • Ian Gans
  • Ellen I Hartig
  • Shusen Zhu
  • Andrea R Tilden
  • Lucie N Hutchins
  • Nathaniel J Maki
  • Joel H Graber
  • James A Coffman
  • Sci Rep.2020 Jul;10(1):11415. 10.1038/s41598-020-68040-z. doi: 10.1038/s41598-020-68040-z.Epub 2020-07-10.

QbD（Quality by Design）アプローチを用いたリバスチグミンを搭載したナノ構造脂質キャリア（NLC）の鼻から脳への送達のための二重最適化。配合変数と機器パラメータ

Double Optimization of Rivastigmine-Loaded Nanostructured Lipid Carriers (NLC) for Nose-to-Brain Delivery Using the Quality by Design (QbD) Approach: Formulation Variables and Instrumental Parameters.
  • Sara Cunha
  • Cláudia Pina Costa
  • Joana A Loureiro
  • Jorge Alves
  • Andreia F Peixoto
  • Ben Forbes
  • José Manuel Sousa Lobo
  • Ana Catarina Silva
  • Pharmaceutics.2020 Jun;12(7). E599. doi: 10.3390/pharmaceutics12070599.Epub 2020-06-28.

鉄硫黄クラスター生合成タンパク質HSCBの変異は、先天性唾液性貧血の原因となる

Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia.
  • Andrew Crispin
  • Chaoshe Guo
  • Caiyong Chen
  • Dean R Campagna
  • Paul J Schmidt
  • Daniel A Lichtenstein
  • Chang Cao
  • Anoop K Sendamarai
  • Gordon J Hildick-Smith
  • Nicholas C Huston
  • Jeanne Boudreaux
  • Sylvia S Bottomley
  • Matthew M Heeney
  • Barry H Paw
  • Mark D Fleming
  • Sarah Ducamp
  • J. Clin. Invest..2020 Jul;135479. doi: 10.1172/JCI135479.Epub 2020-07-07.

HRAS遺伝子変異を有する前治療歴のある転移性尿路粘膜癌患者を対象としたティピファルニブの第II相試験

A phase II trial of tipifarnib for patients with previously-treated, metastatic urothelial carcinoma harboring HRAS mutations.
  • Hye Won Lee
  • Jason Kyungha Sa
  • Antonio Gualberto
  • Catherine Scholz
  • Hyun Hwan Sung
  • Byong Chang Jeong
  • Han Yong Choi
  • Ghee Young Kwon
  • Se Hoon Park
  • Clin. Cancer Res..2020 Jul;clincanres.1246.2020. doi: 10.1158/1078-0432.CCR-20-1246.Epub 2020-07-07.

"若い妊娠中の少女として...あなたが直面する課題"南アフリカの思春期の少女と若い女性の間のメンタルヘルスと性とリプロダクティブヘルスの交錯を探る

"As a Young Pregnant Girl… The Challenges You Face": Exploring the Intersection Between Mental Health and Sexual and Reproductive Health Amongst Adolescent Girls and Young Women in South Africa.
  • Zoe Duby
  • Tracy McClinton Appollis
  • Kim Jonas
  • Kealeboga Maruping
  • Janan Dietrich
  • Ashleigh LoVette
  • Caroline Kuo
  • Lieve Vanleeuw
  • Catherine Mathews
  • AIDS Behav.2020 Jul;10.1007/s10461-020-02974-3. doi: 10.1007/s10461-020-02974-3.Epub 2020-07-18.

小児多発性硬化症患者におけるリンパ球数の時間的プロファイルとフィンゴリモド療法による感染症との関連。PARADIG試験の結果

Temporal profile of lymphocyte counts and relationship with infections with fingolimod therapy in paediatric patients with multiple sclerosis: Results from the PARADIG study.
  • Tanuja Chitnis
  • Brenda Banwell
  • Lauren Krupp
  • Douglas L Arnold
  • Amit Bar-Or
  • Wolfgang Brück
  • Gavin Giovannoni
  • Benjamin Greenberg
  • Angelo Ghezzi
  • Emmanuelle Waubant
  • Kevin Rostasy
  • Kumaran Deiva
  • Peter Huppke
  • Jerry S Wolinsky
  • Ying Zhang
  • Amin Azmon
  • Annik K-Laflamme
  • Rajesh Karan
  • Jutta Gärtner
  • Mult. Scler..2020 Jul;:1352458520936934. doi: 10.1177/1352458520936934.Epub 2020-07-07.

腰椎椎椎間板ヘルニアの治療における経皮的内視鏡的腰椎椎椎間板切除術と開放的腰椎微小椎間板切除術の転帰の比較：2年間のレトロスペクティブコホート研究

A matched comparison of outcomes between percutaneous endoscopic lumbar discectomy and open lumbar microdiscectomy for the treatment of lumbar disc herniation: a two-year retrospective cohort study.
  • Meshal Jarebi
  • Aisha Awaf
  • Johann Peltier
  • Michel Lefranc
  • Spine J.2020 Jul;S1529-9430(20)30960-8. doi: 10.1016/j.spinee.2020.07.005.Epub 2020-07-16.

臨床評価カテゴリーと放射線学的特徴を用いたマルチパラメトリックMRIを用いた末梢部の臨床的に重要な前立腺癌を予測するための機械学習アルゴリズムの比較

Comparison of machine learning algorithms to predict clinically significant prostate cancer of the peripheral zone with multiparametric MRI using clinical assessment categories and radiomic features.
  • Simon Bernatz
  • Jörg Ackermann
  • Philipp Mandel
  • Benjamin Kaltenbach
  • Yauheniya Zhdanovich
  • Patrick N Harter
  • Claudia Döring
  • Renate Hammerstingl
  • Boris Bodelle
  • Kevin Smith
  • Andreas Bucher
  • Moritz Albrecht
  • Nicolas Rosbach
  • Lajos Basten
  • Ibrahim Yel
  • Mike Wenzel
  • Katrin Bankov
  • Ina Koch
  • Felix K-H Chun
  • Jens Köllermann
  • Peter J Wild
  • Thomas J Vogl
  • Eur Radiol.2020 Jul;10.1007/s00330-020-07064-5. doi: 10.1007/s00330-020-07064-5.Epub 2020-07-16.

大腸がん患者におけるイレオストミー閉鎖後の手術部位感染に対する陰圧創傷治療の評価：前向き多施設試験

Evaluation of negative-pressure wound therapy for surgical site infections after ileostomy closure in colorectal cancer patients: a prospective multicenter study.
  • Koichi Okuya
  • Ichiro Takemasa
  • Tetsuhiro Tsuruma
  • Ai Noda
  • Kenichi Sasaki
  • Tomomi Ueki
  • Mitsuhiro Mukaiya
  • Keita Saito
  • Kenji Okita
  • Toshihiko Nishidate
  • Emi Akizuki
  • Atsushi Hamabe
  • Masayuki Ishii
  • Surg. Today.2020 Jul;10.1007/s00595-020-02068-6. doi: 10.1007/s00595-020-02068-6.Epub 2020-07-07.

正方かごめ格子反強磁性体中のギャップレススピン液体

Gapless spin liquid in a square-kagome lattice antiferromagnet.
  • Masayoshi Fujihala
  • Katsuhiro Morita
  • Richard Mole
  • Setsuo Mitsuda
  • Takami Tohyama
  • Shin-Ichiro Yano
  • Dehong Yu
  • Shigetoshi Sota
  • Tomohiko Kuwai
  • Akihiro Koda
  • Hirotaka Okabe
  • Hua Lee
  • Shinichi Itoh
  • Takafumi Hawai
  • Takatsugu Masuda
  • Hajime Sagayama
  • Akira Matsuo
  • Koichi Kindo
  • Seiko Ohira-Kawamura
  • Kenji Nakajima
  • Nat Commun.2020 Jul;11(1):3429. 10.1038/s41467-020-17235-z. doi: 10.1038/s41467-020-17235-z.Epub 2020-07-09.

高齢者向けオンライン・ソーシャル・サポート・プラットフォーム設計のためのユーザー中心アプローチ：ユーザーのタイプと要件の特定

User-Centred Approach to Design an Online Social Support Platform for Seniors : Identification of Users' Types and Their Requirements.
  • Arnaud Ricci
  • Jessica Rochat
  • Henk Herman Nap
  • Lotte Cornelisse
  • Christian Lovis
  • Frédéric Ehrler
  • Stud Health Technol Inform.2020 Jun;270:1081-1085. SHTI200328. doi: 10.3233/SHTI200328.

HARS1の二項対立変異は、ヒスチジルtRNA合成酵素の発現と酵素活性を著しく低下させ、新規の多系統運動失調症候群を引き起こす

Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multisystem ataxic syndrome.
  • Daniele Galatolo
  • Molly E Kuo
  • Patrick Mullen
  • Rebecca Meyer-Schuman
  • Stefano Doccini
  • Roberta Battini
  • Maria Lieto
  • Alessandra Tessa
  • Alessandro Filla
  • Christopher Francklyn
  • Anthony Antonellis
  • Filippo M Santorelli
  • Hum. Mutat..2020 Jul;41(7):1232-1237. doi: 10.1002/humu.24024.Epub 2020-04-29.

組換えスパイク蛋白質のワクチン接種によるラマにおける中東呼吸器症候群コロナウイルス（MERS-CoV）の感染をブロックする

Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein.
  • Jordi Rodon
  • Nisreen M A Okba
  • Nigeer Te
  • Brenda van Dieren
  • Berend-Jan Bosch
  • Albert Bensaid
  • Joaquim Segalés
  • Bart L Haagmans
  • Júlia Vergara-Alert
  • Emerg Microbes Infect.2019;8(1):1593-1603. doi: 10.1080/22221751.2019.1685912.

ソフォスブビルは肝細胞におけるEGFR依存性経路を活性化し、肝関連の病理学的プロセスに影響を及ぼすことが示唆された

Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes.
  • Denisa Bojkova
  • Sandra Westhaus
  • Rui Costa
  • Lejla Timmer
  • Nora Funkenberg
  • Marek Korencak
  • Hendrik Streeck
  • Florian Vondran
  • Ruth Broering
  • Stefan Heinrichs
  • Karl S Lang
  • Sandra Ciesek
  • Cells.2020 Apr;9(4). E1003. doi: 10.3390/cells9041003.Epub 2020-04-17.

南イタリアの非成人の認知健康。卓越した長寿の横断的、家庭ベースのパイロット研究（Cilento Initiative on Aging Outcomes or CIAO）からの記述的分析

Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).
  • Vincenzo Pizza
  • Paola Antonini
  • Rosella Marino
  • Giovanni D'Arena
  • Serena Grazia Lucibello
  • Marianna Rizzo
  • David A Brenner
  • Dilip V Jeste
  • Salvatore Di Somma
  • Medicina (Kaunas).2020 May;56(5). E218. doi: 10.3390/medicina56050218.Epub 2020-05-05.

Achillea abrotanoides (Vis.) Vis.からの新しいロンギピナンケトン：精油の化学変換により、マイナーな成分の同定が可能になった

A new longipinane ketone from Achillea abrotanoides (Vis.) Vis.: chemical transformation of the essential oil enables the identification of a minor constituent.
  • Niko S Radulović
  • Marko Z Mladenović
  • Milenko N Ristić
  • Vidoslav S Dekić
  • Biljana R Dekić
  • Novica R Ristić
  • Phytochem Anal.2020 Jul;31(4):501-515. doi: 10.1002/pca.2913.Epub 2020-01-24.

HIV-1コントローラーにおけるCDKN1A/p21の発現増加は、ZC3H12A/MCPIP1の発現増加と相関していた

Increased expression of CDKN1A/p21 in HIV-1 controllers is correlated with upregulation of ZC3H12A/MCPIP1.
  • Suwellen S D de Azevedo
  • Marcelo Ribeiro-Alves
  • Fernanda H Côrtes
  • Edson Delatorre
  • Lucia Spangenberg
  • Hugo Naya
  • Leonardo N Seito
  • Brenda Hoagland
  • Beatriz Grinsztejn
  • Valdilea G Veloso
  • Mariza G Morgado
  • Thiago Moreno L Souza
  • Gonzalo Bello
  • Retrovirology.2020 Jul;17(1):18. 10.1186/s12977-020-00522-4. doi: 10.1186/s12977-020-00522-4.Epub 2020-07-02.

アキレアミレフォリウムヘキサン抽出物とその主な生理活性化合物のカルシウムチャネル遮断による気管緩和作用

Tracheal relaxation through calcium channel blockade of Achillea millefolium hexanic extract and its main bioactive compounds.
  • Luis Arias-Durán
  • Samuel Estrada-Soto
  • Monserrat Hernández-Morales
  • Fabiola Chávez-Silva
  • Gabriel Navarrete-Vázquez
  • Ismael León-Rivera
  • Irene Perea-Arango
  • Rafael Villalobos-Molina
  • Maximiliano Ibarra-Barajas
  • J Ethnopharmacol.2020 May;253:112643. S0378-8741(19)34431-9. doi: 10.1016/j.jep.2020.112643.Epub 2020-02-05.

生態系代謝は熱帯汽水湿地におけるアタイドシュリンプ（Neocaridina denticulata）における金属の季節的な生物蓄積を制御している

Ecosystem metabolism regulates seasonal bioaccumulation of metals in atyid shrimp (Neocaridina denticulata) in a tropical brackish wetland.
  • Cheng-Hao Tang
  • Wei-Yu Chen
  • Chin-Ching Wu
  • Ezekiel Lu
  • Wan-Yu Shih
  • Jein-Wen Chen
  • Jeng-Wei Tsai
  • Aquat. Toxicol..2020 Jun;225:105522. S0166-445X(20)30272-1. doi: 10.1016/j.aquatox.2020.105522.Epub 2020-06-04.

ヒト細胞におけるDNA損傷応答の遺伝地図

A Genetic Map of the Response to DNA Damage in Human Cells.
  • Michele Olivieri
  • Tiffany Cho
  • Alejandro Álvarez-Quilón
  • Kejiao Li
  • Matthew J Schellenberg
  • Michal Zimmermann
  • Nicole Hustedt
  • Silvia Emma Rossi
  • Salomé Adam
  • Henrique Melo
  • Anne Margriet Heijink
  • Guillermo Sastre-Moreno
  • Nathalie Moatti
  • Rachel K Szilard
  • Andrea McEwan
  • Alexanda K Ling
  • Almudena Serrano-Benitez
  • Tajinder Ubhi
  • Sumin Feng
  • Judy Pawling
  • Irene Delgado-Sainz
  • Michael W Ferguson
  • James W Dennis
  • Grant W Brown
  • Felipe Cortés-Ledesma
  • R Scott Williams
  • Alberto Martin
  • Dongyi Xu
  • Daniel Durocher
  • Cell.2020 Jul;S0092-8674(20)30673-5. doi: 10.1016/j.cell.2020.05.040.Epub 2020-07-09.

新規設計薬である1-(2,3-ジヒドロ-1H-インデン-5-イル)-2-(ピロリジン-1-イル)ブタン-1-オン(5-PPDI)のヒト尿中での第I相代謝物の研究

Studies on the phase I metabolites of the new designer drug 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidine-1-yl)butan-1-one (5-PPDI) in human urine.
  • Ayumu Ishii
  • Kosuke Kusakabe
  • Noriyuki Kato
  • Shin-Ichi Sasaki
  • Kenji Tsujikawa
  • Takeshi Wada
  • Forensic Sci. Int..2020 May;310:110214. S0379-0738(20)30076-1. doi: 10.1016/j.forsciint.2020.110214.Epub 2020-02-29.

鉛に起因するマウス腎細胞におけるセレン含有タンパク質-グルタチオンペルオキシダーゼ3の不活性化に関するin vivoおよびin vitroでの研究

In vivo and in vitro studies on inactivation of selenium containing protein- glutathione peroxidase 3 in mice nephrocytes caused by lead.
  • Hao Zhang
  • Lingyu Luan
  • Mengjiao Bi
  • Lining Zhao
  • Lin Yuan
  • Jia Feng
  • Rutao Liu
  • Ecotoxicol. Environ. Saf..2020 Jul;203:111008. S0147-6513(20)30847-2. doi: 10.1016/j.ecoenv.2020.111008.Epub 2020-07-17.

急性冠症候群患者における大出血および心血管イベントに対するチカクレラー単剤療法とチカクレラーとアスピリンの併用療法の効果。TICO無作為化臨床試験

Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome: The TICO Randomized Clinical Trial.
  • Byeong-Keuk Kim
  • Sung-Jin Hong
  • Yun-Hyeong Cho
  • Kyeong Ho Yun
  • Yong Hoon Kim
  • Yongsung Suh
  • Jae Young Cho
  • Ae-Young Her
  • Sungsoo Cho
  • Dong Woon Jeon
  • Sang-Yong Yoo
  • Deok-Kyu Cho
  • Bum-Kee Hong
  • Hyuckmoon Kwon
  • Chul-Min Ahn
  • Dong-Ho Shin
  • Chung-Mo Nam
  • Jung-Sun Kim
  • Young-Guk Ko
  • Donghoon Choi
  • Myeong-Ki Hong
  • Yangsoo Jang
  • JAMA.2020 06;323(23):2407-2416. 2767161. doi: 10.1001/jama.2020.7580.

Geobacillus stearothermophilus由来L-アラビノースイソメラーゼの酸性条件下での活性向上のための発現と特性評価

Expression and characterization of L-arabinose isomerase from Geobacillus stearothermophilus for improved activity under acidic condition.
  • Fina Amreta Laksmi
  • Shigeki Arai
  • Tsutomu Arakawa
  • Hirohito Tsurumaru
  • Yoshitaka Nakamura
  • Budi Saksono
  • Masao Tokunaga
  • Matsujiro Ishibashi
  • Protein Expr. Purif..2020 Jul;:105692. S1046-5928(20)30283-7. doi: 10.1016/j.pep.2020.105692.Epub 2020-07-15.

駆出率が低下した心不全患者のプロファイルがガイドラインに沿った薬物療法のアドヒアランスに与える影響。VCOR-HF試験

Impact of Individual Patient Profiles on Adherence to Guideline Directed Medical Therapy in Heart Failure With Reduced Ejection Fraction: VCOR-HF Study.
  • Andrea Driscoll
  • Diem Dinh
  • James Wong
  • Ingrid Hopper
  • Justin Mariani
  • Hendrik Zimmet
  • Angela Brennan
  • Jeffery Lefkovits
  • Harriet Carruthers
  • Christopher M Reid
  • Heart Lung Circ.2020 Jun;S1443-9506(20)30238-9. doi: 10.1016/j.hlc.2020.04.012.Epub 2020-06-25.

分野横断的な健康政策とシステム研究の批判的現実主義的統合：特徴的な特徴の定義、評価フレームワークの開発、課題の特定

A critical realist synthesis of cross-disciplinary health policy and systems research: defining characteristic features, developing an evaluation framework and identifying challenges.
  • Gordon Dugle
  • Joseph Kwame Wulifan
  • John Paul Tanyeh
  • Wilm Quentin
  • Health Res Policy Syst.2020 Jul;18(1):79. 10.1186/s12961-020-00556-2. doi: 10.1186/s12961-020-00556-2.Epub 2020-07-14.

次世代シークエンシングによる突然変異陰性先天性好中球減少症の遺伝的バリアントのスクリーニング

Screening of genetic variants in mutation negative congenital neutropenia by next generation sequencing.
  • Arun Kumar Arunachalam
  • Hemamalini Suresh
  • Eunice Sindhuvi Edison
  • Anu Korula
  • Fouzia N Aboobacker
  • Biju George
  • Ramachandran V Shaji
  • Vikram Mathews
  • Poonkuzhali Balasubramanian
  • J. Clin. Pathol..2020 Jun;73(6):322-327. jclinpath-2019-206306. doi: 10.1136/jclinpath-2019-206306.Epub 2019-11-15.

腎細胞癌患者における繊毛新生と VDAC1-ΔC の非存在によって駆動される新たな攻撃性軸の同定

Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients.
  • Lucilla Fabbri
  • Maeva Dufies
  • Sandra Lacas-Gervais
  • Betty Gardie
  • Sophie Gad-Lapiteau
  • Julien Parola
  • Nicolas Nottet
  • Monique Meyenberg Cunha de Padua
  • Julie Contenti
  • Delphine Borchiellini
  • Jean-Marc Ferrero
  • Nathalie Rioux Leclercq
  • Damien Ambrosetti
  • Baharia Mograbi
  • Stéphane Richard
  • Julien Viotti
  • Emmanuel Chamorey
  • Nirvana Sadaghianloo
  • Matthieu Rouleau
  • William J Craigen
  • Bernard Mari
  • Stéphan Clavel
  • Gilles Pagès
  • Jacques Pouysségur
  • Frédéric Bost
  • Nathalie M Mazure
  • Theranostics.2020;10(6):2696-2713. thnov10p2696. doi: 10.7150/thno.41001.Epub 2020-02-03.

ギラン・バレ症候群と診断されたメキシコ人成人の電気生理学的サブタイプと関連する予後因子、単一施設での経験

Electrophysiological subtypes and associated prognosis factors of Mexican adults diagnosed with Guillain-Barré syndrome, a single center experience.
  • Juan Carlos López-Hernández
  • Luis Enrique Colunga-Lozano
  • Sofia Garcia-Trejo
  • Enrique Gomez-Figueroa
  • Guillermo Delgado-Garcia
  • Lisette Bazán-Rodríguez
  • Roberto Cervantes-Uribe
  • Jorge Burgos-Centeno
  • Francisca Fernandez-Valverde
  • Edwin Steven Vargas-Cañas
  • J Clin Neurosci.2020 Jul;S0967-5868(20)30394-5. doi: 10.1016/j.jocn.2020.04.059.Epub 2020-07-13.

ペパーミント（Mentha piperita）粉末の食餌摂取は、カスピ海ローチ（Rutilus caspicus）における成長能、血液学的指標、皮膚粘膜免疫パラメータ、成長およびストレス関連遺伝子の発現に影響を与えます

Dietary peppermint (Mentha piperita) powder affects growth performance, hematological indices, skin mucosal immune parameters, and expression of growth and stress-related genes in Caspian roach (Rutilus caspicus).
  • Hammed Paknejad
  • Seyed Pezhman Hosseini Shekarabi
  • Mehdi Shamsaie Mehrgan
  • Abdolmajid Hajimoradloo
  • Zohre Khorshidi
  • Soheila Rastegari
  • Fish Physiol. Biochem..2020 Jun;10.1007/s10695-020-00839-z. doi: 10.1007/s10695-020-00839-z.Epub 2020-06-26.

ボルテゾミブの神経毒性はカーフィルゾミブに比べてミトコンドリア損傷よりも高いプロテアソームストレスが関与している

Higher proteotoxic stress rather than mitochondrial damage is involved in higher neurotoxicity of bortezomib compared to carfilzomib.
  • Ayse Tarbin Jannuzzi
  • Sema Arslan
  • Ayse Mine Yilmaz
  • Gulce Sari
  • Hande Beklen
  • Lucía Méndez
  • Maria Fedorova
  • Kazim Yalcin Arga
  • Betul Karademir Yilmaz
  • Buket Alpertunga
  • Redox Biol.2020 05;32:101502. S2213-2317(19)31437-5. doi: 10.1016/j.redox.2020.101502.Epub 2020-03-21.

再発性多発性硬化症患者における腸管透過性の変化。パイロット研究

Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study.
  • Maria Chiara Buscarinu
  • Benedetta Cerasoli
  • Viviana Annibali
  • Claudia Policano
  • Luana Lionetto
  • Matilde Capi
  • Rosella Mechelli
  • Silvia Romano
  • Arianna Fornasiero
  • Gianluca Mattei
  • Eleonora Piras
  • Daniela Francesca Angelini
  • Luca Battistini
  • Maurizio Simmaco
  • Renato Umeton
  • Marco Salvetti
  • Giovanni Ristori
  • Mult. Scler..2017 Mar;23(3):442-446. 1352458516652498. doi: 10.1177/1352458516652498.Epub 2016-07-11.

マイクロケラトームを用いた2ピースのキノコ角膜形成術は、疾患のある梗塞と健康な内皮を持つ眼に行われた移植片の成績と生存率を向上させます（米国眼科学会論文）

A Two-Piece Microkeratome-Assisted Mushroom Keratoplasty Improves the Outcomes and Survival of Grafts Performed in Eyes with Diseased Stroma and Healthy Endothelium (An American Ophthalmological Society Thesis).
  • Massimo Busin
  • Silvana Madi
  • Vincenzo Scorcia
  • Paolo Santorum
  • Yoav Nahum
  • Trans Am Ophthalmol Soc.2015;113:T1.

慢性脊髄損傷の長期手動車いす利用者におけるロボット外骨格を用いた地上歩行プログラムの効果．自己対照介入研究のためのプロトコル

Effects of an Overground Walking Program with a Robotic Exoskeleton in Long-Term Manual Wheelchair Users with a Chronic Spinal Cord Injury: Protocol for a Self-Controlled Interventional Study.
  • Alec Bass
  • Mylène Aubertin-Leheudre
  • Claude Vincent
  • Antony D Karelis
  • Suzanne N Morin
  • Michelle McKerral
  • Cyril Duclos
  • Dany H Gagnon
  • JMIR Res Protoc.2020 Jul;doi: 10.2196/19251.Epub 2020-07-07.

水生生態系における金属汚染のモニタリングにおける魚類の蠕虫寄生虫の役割：世界で最も生産量の多いプラチナ採掘地域における事例研究

The role of fish helminth parasites in monitoring metal pollution in aquatic ecosystems: a case study in the world's most productive platinum mining region.
  • Johannes H Erasmus
  • Victor Wepener
  • Milen Nachev
  • Sonja Zimmermann
  • Wynand Malherbe
  • Bernd Sures
  • Nico J Smit
  • Parasitol. Res..2020 Jul;10.1007/s00436-020-06813-1. doi: 10.1007/s00436-020-06813-1.Epub 2020-07-18.

パクリタキセルとsiRNA-E7をHPV関連子宮頸部悪性腫瘍に共同投与するためのバイオインスパイアされた腫瘍ホーミングナノプラットフォームは、相乗効果のある治療のためのものである

Bioinspired tumor-homing nanoplatform for co-delivery of paclitaxel and siRNA-E7 to HPV-related cervical malignancies for synergistic therapy.
  • Cong Xu
  • Wan Liu
  • Yuan Hu
  • Weiping Li
  • Wen Di
  • Theranostics.2020;10(7):3325-3339. thnov10p3325. doi: 10.7150/thno.41228.Epub 2020-02-10.

子宮UDP-グルクロンオキシルトランスフェラーゼ1A8（UGT1A8）およびUDP-グルクロンオキシルトランスフェラーゼ2B7（UGT2B7）の機能は、エストロゲン代謝調節に基づいて子宮内膜癌に関与している

The function of uterine UDP-glucuronosyltransferase 1A8 (UGT1A8) and UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in endometrial cancer based on estrogen metabolism regulation.
  • Feng Zhao
  • Xi Wang
  • Yan Wang
  • Jingbo Zhang
  • Ran Lai
  • Bei Zhang
  • Xueyan Zhou
  • Hormones (Athens).2020 Jun;10.1007/s42000-020-00213-x. doi: 10.1007/s42000-020-00213-x.Epub 2020-06-26.

切除不能な肝門部胆管癌に対する肝移植とネオアジュバント化学放射線療法の併用の適用性と結果

Applicability and results of liver transplant combined with neoadjuvant chemo-radiotherapy in the treatment of unresectable hilar cholangiocarcinoma.
  • Cristina Dopazo
  • L Lladó
  • C Fondevila
  • T Macarulla
  • B Navalpotro
  • E Ramos
  • J Fabregat
  • B Laquente
  • M Navasa
  • L Castells
  • I Bilbao
  • J C García Valdecasas
  • R Charco
  • Cir Esp.2020 Jul;S0009-739X(20)30216-5. doi: 10.1016/j.ciresp.2020.06.009.Epub 2020-07-15.

多発性硬化症患者におけるペントラキシンおよびプロ炎症性サイトカインに対する複合運動トレーニングの効果

Effect of combined exercise training on pentraxins and pro- inflammatory cytokines in people with multiple sclerosis as a function of disability status.
  • Mohammad Faramarzi
  • Ebrahim Banitalebi
  • Zahra Raisi
  • Masoumeh Samieyan
  • Zahra Saberi
  • Majid Mardaniyan Ghahfarrokhi
  • Raoof Negaresh
  • Robert W Motl
  • Cytokine.2020 Jul;134:155196. S1043-4666(20)30212-X. doi: 10.1016/j.cyto.2020.155196.Epub 2020-07-16.

肺ランゲルハンス細胞組織球症における運動制限と肺高血圧の有病率の機序

Mechanisms of exercise limitation and prevalence of pulmonary hypertension in pulmonary Langerhans cell histiocytosis.
  • Glaucia Itamaro Heiden
  • Juliana Barbosa Sobral
  • Carolina Salim Gonçalves Freitas
  • André Luis Pereira de Albuquerque
  • João Marcos Salge
  • Ronaldo Adib Kairalla
  • Caio Júlio César Dos Santos Fernandes
  • Carlos Roberto Ribeiro Carvalho
  • Rogério Souza
  • Bruno Guedes Baldi
  • Chest.2020 Jun;S0012-3692(20)31823-7. doi: 10.1016/j.chest.2020.05.609.Epub 2020-06-29.

Hsa-miR-139-5pは、HNRNPF媒介の代替スプライシングに関与する甲状腺癌の予後マーカーである

Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing.
  • Cristina Montero-Conde
  • Osvaldo Graña-Castro
  • Guillermo Martín-Serrano
  • Ángel M Martínez-Montes
  • Eduardo Zarzuela
  • Javier Muñoz
  • Rafael Torres-Perez
  • Guillermo Pita
  • Alfonso Cordero-Barreal
  • Luis J Leandro-García
  • Rocío Letón
  • Isabel López de Silanes
  • Sonsoles Guadalix
  • Andrés Pérez-Barrios
  • Federico Hawkins
  • Almudena Guerrero-Álvarez
  • Cristina Álvarez-Escolá
  • Rita M Regojo-Zapata
  • Bruna Calsina
  • Laura Remacha
  • Juan M Roldán-Romero
  • María Santos
  • Javier Lanillos
  • Mireia Jordá
  • Garcilaso Riesco-Eizaguirre
  • Carles Zafon
  • Anna González-Neira
  • Maria A Blasco
  • Fátima Al-Shahrour
  • Cristina Rodríguez-Antona
  • Alberto Cascón
  • Mercedes Robledo
  • Int. J. Cancer.2020 01;146(2):521-530. doi: 10.1002/ijc.32622.Epub 2019-08-28.

Candida glabrataのPDR1の機能獲得変異は、メディエーターサブユニットGal11Aのリクルートを促進することにより、EPA1の発現を低下させ、上皮細胞への付着を減少させる

A gain-of-function mutation in PDR1 of Candida glabrata decreases EPA1 expression and attenuates adherence to epithelial cells through enhancing recruitment of the Mediator subunit Gal11A.
  • Yuan Tian
  • Yihui Zhuang
  • Zhujun Chen
  • Yinhe Mao
  • Jing Zhang
  • Renquan Lu
  • Lin Guo
  • Microbiol. Res..2020 Jun;239:126519. S0944-5013(20)30387-6. doi: 10.1016/j.micres.2020.126519.Epub 2020-06-03.

原発性骨癌の診断のためのバイオマーカーとしてのSOX9の局所・循環動態を明らかにした

The local and circulating SOX9 as a potential biomarker for the diagnosis of primary bone cancer.
  • Ameinh Hosseini
  • Alireza Mirzaei
  • Vahid Salimi
  • Khodamorad Jamshidi
  • Pegah Babaheidarian
  • Soudabeh Fallah
  • Zahra Rampisheh
  • Narges Khademian
  • Zohreh Abdolvahabi
  • Mehrdad Bahrabadi
  • Mostafa Ibrahimi
  • Fatemeh Hosami
  • Masoumeh Tavakoli-Yaraki
  • J Bone Oncol.2020 Aug;23:100300. S2212-1374(20)30055-5. doi: 10.1016/j.jbo.2020.100300.Epub 2020-05-31.

バイカルリンは、新生児ニューロンにおけるp38ミトゲン活性化プロテインキナーゼ（MAPK）シグナル伝達を調節することにより、ビリルビン誘導性のアポトーシスと炎症を抑制する

Baicalin Suppresses Bilirubin-Induced Apoptosis and Inflammation by Regulating p38 Mitogen-Activated Protein Kinases (MAPK) Signaling in Neonatal Neurons.
  • Shuang Shi
  • Qianwei Cui
  • Jing Xu
  • Zhiguo Tang
  • Binya Shi
  • Zhongwei Liu
  • Med. Sci. Monit..2020 Jul;26:e926441. 926441. doi: 10.12659/MSM.926441.Epub 2020-07-07.

パルスレーザー堆積法で成長させた相純度UO2, α-UO3O8, α-UO3エピタキシャル薄膜の構造と光学特性

Structural and optical properties of phase-pure UO2, α-U3O8 and α-UO3 epitaxial thin films grown by pulsed laser deposition.
  • Erik Enriquez
  • Gaoxue Wang
  • Yogesh Sharma
  • Ibrahim Sarpkaya
  • Qiang Wang
  • Di Chen
  • Nicholas Winner
  • Xiaofeng Guo
  • John Dunwoody
  • Joshua T White
  • Andrew Nelson
  • Hongwu Xu
  • Paul Dowden
  • Enrique R Batista
  • Han Htoon
  • Ping Yang
  • Quanxi Jia
  • Aiping Chen
  • ACS Appl Mater Interfaces.2020 Jul;doi: 10.1021/acsami.0c08635.Epub 2020-07-15.

Ai-lncRNA EGOT増強オートファジーは、ヒト癌におけるRNA-RNAとRNA-タンパク質相互作用によるITPR1発現のアップレギュレーションを介してパクリタキセルの細胞毒性を増感させる

Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer.
  • Shouping Xu
  • Peiyuan Wang
  • Jian Zhang
  • Hao Wu
  • Shiyao Sui
  • Jinfeng Zhang
  • Qin Wang
  • Kun Qiao
  • Weiwei Yang
  • Hongbiao Xu
  • Da Pang
  • Mol. Cancer.2019 04;18(1):89. 10.1186/s12943-019-1017-z. doi: 10.1186/s12943-019-1017-z.Epub 2019-04-18.

Bcl2 阻害剤 ABT737 は Sirt3-HIF1α 軸を介して Warburg 効果を逆転させ、卵巣癌細胞の酸化ストレス誘発アポトーシスを促進することを明らかにした

Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
  • Delu Dong
  • Yuan Dong
  • Jiaying Fu
  • Shengyao Lu
  • Chunli Yuan
  • Meihui Xia
  • Liankun Sun
  • Life Sci..2020 Aug;255:117846. S0024-3205(20)30596-8. doi: 10.1016/j.lfs.2020.117846.Epub 2020-05-26.

顎切除術後の咀嚼機能のパイロット研究として、人工関節を用いたリハビリテーションと、デジタル計画されたプレハブで自由な血管化された腓骨フラップを用いた再建を比較しました

A pilot study of masticatory function after maxillectomy comparing rehabilitation with an obturator prosthesis and reconstruction with a digitally planned, prefabricated, free, vascularized fibula flap.
  • Reilly J de Groot
  • Jana M Rieger
  • Antoine J W P Rosenberg
  • Matthias A W Merkx
  • Caroline M Speksnijder
  • J Prosthet Dent.2020 Jan;S0022-3913(19)30413-5. doi: 10.1016/j.prosdent.2019.06.005.Epub 2020-01-17.

Kv2.1チャネルは、動脈平滑筋の膜電位、Caチャネル機能、筋原性トーンの調節に相反する役割を果たしている

Kv2.1 channels play opposing roles in regulating membrane potential, Ca channel function, and myogenic tone in arterial smooth muscle.
  • Samantha C O'Dwyer
  • Stephanie Palacio
  • Collin Matsumoto
  • Laura Guarina
  • Nicholas R Klug
  • Sendoa Tajada
  • Barbara Rosati
  • David McKinnon
  • James S Trimmer
  • L Fernando Santana
  • Proc. Natl. Acad. Sci. U.S.A..2020 02;117(7):3858-3866. 1917879117. doi: 10.1073/pnas.1917879117.Epub 2020-02-03.

カレチキュリンは、ヒ素暴露したHT-22細胞において、ERストレスを媒介としたミトコンドリア依存性の独立した経路を介して、内在性アポトーシスを制御していた

Calreticulin regulated intrinsic apoptosis through mitochondria-dependent and independent pathways mediated by ER stress in arsenite exposed HT-22 cells.
  • Xiaotong Wang
  • Xudan Liu
  • Yao Chen
  • Huanhuan Wang
  • Ruo Zhang
  • Qianhui Zhang
  • Yuting Wei
  • Sainan Shi
  • Xin Li
  • Chemosphere.2020 Jul;251:126466. S0045-6535(20)30659-7. doi: 10.1016/j.chemosphere.2020.126466.Epub 2020-03-10.

招待解説''Transforming laparoendoscopic surgical protocols during COVID-19 pandemic; big data analytics, resource allocation and operational considerations; a review article''について

An Invited commentary on '' Transforming laparoendoscopic surgical protocols during COVID-19 pandemic; big data analytics, resource allocation and operational considerations; a review article''.
  • Ali Abbaszadeh-Kasbi
  • Paria Nikzad
  • Int J Surg.2020 Jul;S1743-9191(20)30540-9. doi: 10.1016/j.ijsu.2020.07.005.Epub 2020-07-14.

イメージング眼球微小血管系。光コヒーレンス・トモグラフィー血管造影と適応光学スキャン光検眼鏡フルオレセイン血管造影

Imaging Foveal Microvasculature: Optical Coherence Tomography Angiography Versus Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography.
  • Shelley Mo
  • Brian Krawitz
  • Eleni Efstathiadis
  • Lawrence Geyman
  • Rishard Weitz
  • Toco Y P Chui
  • Joseph Carroll
  • Alfredo Dubra
  • Richard B Rosen
  • Invest. Ophthalmol. Vis. Sci..2016 07;57(9):OCT130-40. 2534098. doi: 10.1167/iovs.15-18932.

胎児膜を保持している場合と保持していない場合の妊娠中および分娩中のウシ胎盤における選択されたグリコシダーゼの活性とそれらの基質の可用性

Activity of selected glycosidases and availability of their substrates in bovine placenta during pregnancy and parturition with and without retained foetal membranes.
  • Monika Jamioł
  • Jacek Wawrzykowski
  • Wioleta Mojsym
  • Martina Hoedemaker
  • Marta Kankofer
  • Reprod. Domest. Anim..2020 Jun;doi: 10.1111/rda.13747.Epub 2020-06-13.

心血管リスク因子との関係における内膜石灰化と内膜石灰化

Intimal and medial calcification in relation to cardiovascular risk factors.
  • Sabine R Zwakenberg
  • Pim A de Jong
  • Eva J Hendriks
  • Jan Westerink
  • Wilko Spiering
  • Gert J de Borst
  • Maarten J Cramer
  • Jonas W Bartstra
  • Teddo Doesburg
  • Femke Rutters
  • Amber A van der Heijden
  • Casper Schalkwijk
  • Leon J Schurgers
  • Yvonne T van der Schouw
  • Joline W J Beulens
  • PLoS ONE.2020;15(7):e0235228. PONE-D-20-05983. doi: 10.1371/journal.pone.0235228.Epub 2020-07-13.

グラム陰性病原体AcrBトランスポーターのフルオロキノロン耐性変異体の低温電子顕微鏡構造と分子動力学解析

Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from .
  • Rachel M Johnson
  • Chiara Fais
  • Mayuriben Parmar
  • Harish Cheruvara
  • Robert L Marshall
  • Sophie J Hesketh
  • Matthew C Feasey
  • Paolo Ruggerone
  • Attilio V Vargiu
  • Vincent L G Postis
  • Stephen P Muench
  • Vassiliy N Bavro
  • Microorganisms.2020 Jun;8(6). E943. doi: 10.3390/microorganisms8060943.Epub 2020-06-23.

アミノ基とフェニル基を有するCu(II)イオン錯体で機能化したシリカ粒子をベースとした抗菌・抗真菌剤の多様な合成法の開発

Diverse Pathway to Obtain Antibacterial and Antifungal Agents Based on Silica Particles Functionalized by Amino and Phenyl Groups with Cu(II) Ion Complexes.
  • Veronika V Tomina
  • Iryna M Furtat
  • Anastasia P Lebed
  • Sofiya S Kotsyuda
  • Hristo Kolev
  • Maria Kanuchova
  • Dominika Marcin Behunova
  • Miroslava Vaclavikova
  • Inna V Melnyk
  • ACS Omega.2020 Jun;5(25):15290-15300. doi: 10.1021/acsomega.0c01335.Epub 2020-06-16.

ブタの脳死後の心臓死後に提供された肝移植片の病理学的特徴

Pathological characteristics of liver allografts from donation after brain death followed by cardiac death in pigs.
  • Hui Ye
  • Dong-Ping Wang
  • Chuan-Zhao Zhang
  • Long-Juan Zhang
  • Hao-Chen Wang
  • Zhuo-Hui Li
  • Zhen Chen
  • Tao Zhang
  • Chang-Jie Cai
  • Wei-Qiang Ju
  • Yi Ma
  • Zhi-Yong Guo
  • Xiao-Shun He
  • J. Huazhong Univ. Sci. Technol. Med. Sci..2014 Oct;34(5):687-691. 10.1007/s11596-014-1337-6. doi: 10.1007/s11596-014-1337-6.Epub 2014-10-16.

プロリンリッチ11（PRR11）は、ヒト非小細胞肺癌細胞において、アクチン関連タンパク質2/3複合体をリクルートすることにより、F-アクチンアセンブリを駆動していることが明らかになった

Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma.
  • Lian Zhang
  • Ying Zhang
  • Yunlong Lei
  • Zhili Wei
  • Yi Li
  • Yingxiong Wang
  • Youquan Bu
  • Chundong Zhang
  • J. Biol. Chem..2020 Apr;295(16):5335-5349. RA119.012260. doi: 10.1074/jbc.RA119.012260.Epub 2020-03-13.

正常なヒトのエンシスには、制御性と誘導性のあるIL-17AおよびTNF発現を有する従来型のCD4+およびCD8+ T細胞が存在している

Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression.
  • Abdulla Watad
  • Hannah Rowe
  • Tobias Russell
  • Qiao Zhou
  • Lisa K Anderson
  • Almas Khan
  • Robert Dunsmuir
  • Peter Loughenbury
  • Vishal Borse
  • Abhay Rao
  • Peter A Millner
  • Nicola Luigi Bragazzi
  • Howard Amital
  • Richard Cuhtbert
  • Miriam Wittmann
  • Kassem Sharif
  • Tony Kenna
  • Matthew A Brown
  • Darren Newton
  • Charlie Bridgewood
  • Dennis G McGonagle
  • Ann. Rheum. Dis..2020 Aug;79(8):1044-1054. annrheumdis-2020-217309. doi: 10.1136/annrheumdis-2020-217309.Epub 2020-05-13.

ニジマス（Oncorhynchus mykiss）骨格筋のFlavobacterium psychrophilumに対するトランスクリプトーム応答

Transcriptomic response of rainbow trout (Oncorhynchus mykiss) skeletal muscle to Flavobacterium psychrophilum.
  • Andrea Rivas-Aravena
  • Marcia Fuentes-Valenzuela
  • Sebastian Escobar-Aguirre
  • Cristian Gallardo-Escarate
  • Alfredo Molina
  • Juan Antonio Valdés
  • Comp. Biochem. Physiol. Part D Genomics Proteomics.2019 09;31:100596. S1744-117X(19)30037-1. doi: 10.1016/j.cbd.2019.100596.Epub 2019-05-29.

355 nmの新しいナノ秒UVレーザー：ウサギモデルにおける角膜フラップ切開の初期結果

A new nanosecond UV laser at 355 nm: early results of corneal flap cutting in a rabbit model.
  • Andrea Trost
  • Falk Schrödl
  • Clemens Strohmaier
  • Barbara Bogner
  • Christian Runge
  • Alexandra Kaser-Eichberger
  • Karolina Krefft
  • Alfred Vogel
  • Norbert Linz
  • Sebastian Freidank
  • Andrea Hilpert
  • Inge Zimmermann
  • Günther Grabner
  • Herbert A Reitsamer
  • Invest. Ophthalmol. Vis. Sci..2013 Dec;54(13):7854-64. iovs.13-12580. doi: 10.1167/iovs.13-12580.Epub 2013-12-03.

乳がん幹細胞RNAパルス化樹状細胞はエフェクターT細胞による腫瘍細胞の殺傷力を高める

Breast cancer stem cell RNA-pulsed dendritic cells enhance tumor cell killing by effector T cells.
  • Nuttavut Sumransub
  • Niphat Jirapongwattana
  • Pranisa Jamjuntra
  • Suyanee Thongchot
  • Thaweesak Chieochansin
  • Pa-Thai Yenchitsomanus
  • Peti Thuwajit
  • Malee Warnnissorn
  • Pornchai O-Charoenrat
  • Chanitra Thuwajit
  • Oncol Lett.2020 Mar;19(3):2422-2430. OL-0-0-11338. doi: 10.3892/ol.2020.11338.Epub 2020-01-23.

進行胃がん患者における第一選択療法としてのS-1＋ロイコボリンおよびオキサリプラチンとS-1＋シスプラチンの併用療法（SOLAR）：無作為化、非盲検、第3相試験

S-1 plus leucovorin and oxaliplatin versus S-1 plus cisplatin as first-line therapy in patients with advanced gastric cancer (SOLAR): a randomised, open-label, phase 3 trial.
  • Yoon-Koo Kang
  • Keisho Chin
  • Hyun Cheol Chung
  • Shigenori Kadowaki
  • Sang Cheul Oh
  • Norisuke Nakayama
  • Keun-Wook Lee
  • Hiroki Hara
  • Ik-Joo Chung
  • Masahiro Tsuda
  • Se Hoon Park
  • Hisashi Hosaka
  • Shuichi Hironaka
  • Yoshinori Miyata
  • Min-Hee Ryu
  • Hideo Baba
  • Ichinosuke Hyodo
  • Yung-Jue Bang
  • Narikazu Boku
  • Lancet Oncol..2020 Jul;S1470-2045(20)30315-6. doi: 10.1016/S1470-2045(20)30315-6.Epub 2020-07-16.

口腔内微生物叢と免疫系のクロストーク。トランスレーショナルリサーチ

Oral Microbiota and Immune System Crosstalk: A Translational Research.
  • Andrea Ballini
  • Gianna Dipalma
  • Ciro Gargiulo Isacco
  • Mariarosaria Boccellino
  • Marina Di Domenico
  • Luigi Santacroce
  • Kieu C D Nguyễn
  • Salvatore Scacco
  • Maura Calvani
  • Anna Boddi
  • Fabiana Corcioli
  • Lucio Quagliuolo
  • Stefania Cantore
  • Francesco Saverio Martelli
  • Francesco Inchingolo
  • Biology (Basel).2020 Jun;9(6). E131. doi: 10.3390/biology9060131.Epub 2020-06-16.

キナクリンは、ヒト非小細胞肺癌細胞株において、GSTA1の活性を阻害し、G/S停止と活性酸素の発生を介してアポトーシスを誘導する

Quinacrine inhibits GSTA1 activity and induces apoptosis through G/S arrest and generation of ROS in human non-small cell lung cancer cell lines.
  • Makhan Kumar
  • Ansie Martin
  • Snehal Nirgude
  • Bibha Chaudhary
  • Sukanta Mondal
  • Angshuman Sarkar
  • Oncotarget.2020 May;11(18):1603-1617. 27558. doi: 10.18632/oncotarget.27558.Epub 2020-05-05.

カチオン性両親媒性薬剤のフィロウイルス抗ウイルス活性は、親油性およびリン脂質症を誘導する能力と関連している

Filovirus antiviral activity of cationic amphiphilic drugs is associated with lipophilicity and ability to induce phospholipidosis.
  • Antonia P Gunesch
  • Francisco J Zapatero-Belinchon
  • Lukas Pinkert
  • Eike Steinmann
  • Michael P Manns
  • Gisbert Schneider
  • Thomas Pietschmann
  • Mark Brönstrup
  • Thomas von Hahn
  • Antimicrob. Agents Chemother..2020 Jun;AAC.00143-20. doi: 10.1128/AAC.00143-20.Epub 2020-06-08.

X-linked, syndromic mental retardationを有する2人の男性が、HNRNPH2のde novo変異を有する

Two additional males with X-linked, syndromic mental retardation carry de novo mutations in HNRNPH2.
  • Wayne M Jepsen
  • Keri Ramsey
  • Szabolcs Szelinger
  • Lorida Llaci
  • Chris Balak
  • Newell Belnap
  • Cherae Bilagody
  • Matthew De Both
  • Raj Gupta
  • Marcus Naymik
  • Richa Pandey
  • Ignazio S Piras
  • Meredith Sanchez-Castillo
  • Sampathkumar Rangasamy
  • Vinodh Narayanan
  • Matthew J Huentelman
  • Clin. Genet..2019 08;96(2):183-185. doi: 10.1111/cge.13580.Epub 2019-06-24.

高リスク食道静脈瘤患者に対するβ遮断薬治療の反応性を評価するための脾臓硬直度測定

Spleen stiffness measurement for assessing the response to β-blockers therapy for high-risk esophageal varices patients.
  • Giovanni Marasco
  • Elton Dajti
  • Federico Ravaioli
  • Luigina Vanessa Alemanni
  • Fabiana Capuano
  • Kamela Gjini
  • Luigi Colecchia
  • Giovanni Puppini
  • Caterina Cusumano
  • Matteo Renzulli
  • Rita Golfieri
  • Davide Festi
  • Antonio Colecchia
  • Hepatol Int.2020 Jun;10.1007/s12072-020-10062-w. doi: 10.1007/s12072-020-10062-w.Epub 2020-06-15.

非定型Wiskott-Aldrich症候群を呈する南アフリカの患者における新規WAS突然変異の同定：症例報告

Identification of a novel WAS mutation in a South African patient presenting with atypical Wiskott-Aldrich syndrome: a case report.
  • Brigitte Glanzmann
  • Marlo Möller
  • Mardelle Schoeman
  • Michael Urban
  • Paul D van Helden
  • Lisa Frigati
  • Ravnit Grewal
  • Hermanus Pieters
  • Ben Loos
  • Eileen G Hoal
  • Richard H Glashoff
  • Helena Cornelissen
  • Helena Rabie
  • Monika M Esser
  • Craig J Kinnear
  • BMC Med. Genet..2020 Jun;21(1):124. 10.1186/s12881-020-01054-6. doi: 10.1186/s12881-020-01054-6.Epub 2020-06-05.

赤尾鷹()の合成脛骨モデルにおけるFixateur Externe du Service de Santé des Arméesとアクリル製タイイン式外骨格固定装置のねじれ特性の比較

Comparison of torsional properties between a Fixateur Externe du Service de Santé des Armées and an acrylic tie-in external skeletal fixator in a red-tailed hawk () synthetic tibiotarsal bone model.
  • Rebecca A Hersh-Boyle
  • Amy S Kapatkin
  • Tanya C Garcia
  • Duane A Robinson
  • David Sanchez-Migallon Guzman
  • Shannon M Kerrigan
  • Po-Yen Chou
  • Susan M Stover
  • Am. J. Vet. Res..2020 Jul;81(7):557-564. doi: 10.2460/ajvr.81.7.557.

CDK8はRAP2.6やSnRK2.6と関連しており、シロイヌナズナにおいてアブサイシン酸シグナル伝達や干ばつ応答を正に制御している

CDK8 is associated with RAP2.6 and SnRK2.6 and positively modulates abscisic acid signaling and drought response in Arabidopsis.
  • Yingfang Zhu
  • Pengcheng Huang
  • Pengcheng Guo
  • Leelyn Chong
  • Gaobo Yu
  • Xiaoli Sun
  • Tao Hu
  • Yuan Li
  • Chuan-Chih Hsu
  • Kai Tang
  • Yun Zhou
  • Chunzhao Zhao
  • Wei Gao
  • W Andy Tao
  • Tesfaye Mengiste
  • Jian-Kang Zhu
  • New Phytol..2020 Jul;doi: 10.1111/nph.16787.Epub 2020-07-03.

農村部の家庭医学クリニックにおける癌以外の慢性疼痛患者におけるオピオイド処方全体に対する包括的なオピオイド削減プロトコルの実施の効果。A Controlled Cross-over Trial

Effects of Implementing a Comprehensive Opioid Reduction Protocol on Overall Opioid Prescribing Among Patients with Chronic, Non-Cancer Pain in a Rural Family Medicine Clinic: A Controlled Cross-over Trial.
  • Matthew Stack
  • Vanessa LaRouche
  • Yezi Zhang
  • Daniel Warden
  • Charles Stack
  • Egle A Klugiene
  • J Am Board Fam Med.2020 Jul-Aug;33(4):502-511. 33/4/502. doi: 10.3122/jabfm.2020.04.200060.

再発リスクの高い腹腔鏡下裂孔ヘルニア修復術と食道括約筋補強術（LINX）に対するfundic gastropexyの追加は、周術期の経過を変えることなく転帰を改善する

Fundic gastropexy for high risk of recurrence laparoscopic hiatal hernia repair and esophageal sphincter augmentation (LINX) improves outcomes without altering perioperative course.
  • Robert Allman
  • James Speicher
  • Austin Rogers
  • Ethan Ledbetter
  • Aundrea Oliver
  • Mark Iannettoni
  • Carlos Anciano
  • Surg Endosc.2020 Jul;10.1007/s00464-020-07789-w. doi: 10.1007/s00464-020-07789-w.Epub 2020-07-17.

カフェインを含む、適応性の高い飲み物は、精神的パフォーマンスと認知パラメーターに対するカフェインの効果を変調させる。二重盲検、プラセボ対照、無作為化試験

Caffeine-Containing, Adaptogenic-Rich Drink Modulates the Effects of Caffeine on Mental Performance and Cognitive Parameters: A Double-Blinded, Placebo-Controlled, Randomized Trial.
  • Ali Boolani
  • Daniel T Fuller
  • Sumona Mondal
  • Tyler Wilkinson
  • Costel C Darie
  • Eric Gumpricht
  • Nutrients.2020 Jun;12(7). E1922. doi: 10.3390/nu12071922.Epub 2020-06-29.

治療抵抗性うつ病におけるエスケタミン皮下投与の血圧・心拍数への影響

Effects of subcutaneous esketamine on blood pressure and heart rate in treatment-resistant depression.
  • Lorena Catarina Del Sant
  • Luciana Maria Sarin
  • Eduardo Jorge Muniz Magalhães
  • Ana Cecília Lucchese
  • Marco Aurélio Tuena
  • Carolina Nakahira
  • Victor Augusto Rodovalho Fava
  • Rodrigo Delfino
  • Juliana Surjan
  • Matheus Souza Steiglich
  • Matheus Barbosa
  • Guilherme Abdo
  • Frederico Molina Cohrs
  • Aroldo Liberatori
  • José Alberto Del Porto
  • Acioly Luiz Tavares Lacerda
  • Jair de Jesus Mari
  • J. Psychopharmacol. (Oxford).2020 Jul;:269881120922955. doi: 10.1177/0269881120922955.Epub 2020-07-08.

マイクロサテライトパネルを用いて、中国への輸入ファルシパルム・マラリア症例の局所伝播の欠如と地理的割り当てを確認した

Confirmation of the absence of local transmission and geographic assignment of imported falciparum malaria cases to China using microsatellite panel.
  • Yaobao Liu
  • Sofonias K Tessema
  • Maxwell Murphy
  • Sui Xu
  • Alanna Schwartz
  • Weiming Wang
  • Yuanyuan Cao
  • Feng Lu
  • Jianxia Tang
  • Yaping Gu
  • Guoding Zhu
  • Huayun Zhou
  • Qi Gao
  • Rui Huang
  • Jun Cao
  • Bryan Greenhouse
  • Malar. J..2020 Jul;19(1):244. 10.1186/s12936-020-03316-3. doi: 10.1186/s12936-020-03316-3.Epub 2020-07-13.

T2強調シーケンスを用いた高速シネ磁気共鳴イメージングによる咽頭機能の評価：予備的研究

Evaluation of velopharyngeal function using high-speed cine-magnetic resonance imaging based on T2-weighted sequences: a preliminary study.
  • T Joujima
  • M Oda
  • M Sasaguri
  • M Habu
  • S Kataoka
  • Y Miyamura
  • N Wakasugi-Sato
  • S Matsumoto-Takeda
  • O Takahashi
  • S Kokuryo
  • T Sago
  • D Yoshiga
  • T Tanaka
  • Y Morimoto
  • Int J Oral Maxillofac Surg.2020 Apr;49(4):432-441. S0901-5027(19)31268-8. doi: 10.1016/j.ijom.2019.08.001.Epub 2019-08-23.

入院時のNational Early Warning Score 2（NEWS2）はCovid-19による重症化と院内死亡を予測する-プロスペクティブコホート研究

National Early Warning Score 2 (NEWS2) on admission predicts severe disease and in-hospital mortality from Covid-19 - a prospective cohort study.
  • Marius Myrstad
  • Håkon Ihle-Hansen
  • Anders Aune Tveita
  • Elizabeth Lyster Andersen
  • Ståle Nygård
  • Arnljot Tveit
  • Trygve Berge
  • Scand J Trauma Resusc Emerg Med.2020 Jul;28(1):66. 10.1186/s13049-020-00764-3. doi: 10.1186/s13049-020-00764-3.Epub 2020-07-13.

COVID-19パンデミック時の英国およびアイルランドにおけるコミュニティ看取りケアにおける予見的処方：オンライン調査

Anticipatory prescribing in community end-of-life care in the UK and Ireland during the COVID-19 pandemic: online survey.
  • Bárbara Antunes
  • Ben Bowers
  • Isaac Winterburn
  • Michael P Kelly
  • Robert Brodrick
  • Kristian Pollock
  • Megha Majumder
  • Anna Spathis
  • Iain Lawrie
  • Rob George
  • Richella Ryan
  • Stephen Barclay
  • BMJ Support Palliat Care.2020 Jun;bmjspcare-2020-002394. doi: 10.1136/bmjspcare-2020-002394.Epub 2020-06-16.

矯正治療の初期段階でクリアアライナーを受けている患者と固定装置を受けている患者との間で、痛みの知覚、不安、口腔保健関連のQOLへの影響を比較した

Comparison of pain perception, anxiety, and impacts on oral health-related quality of life between patients receiving clear aligners and fixed appliances during the initial stage of orthodontic treatment.
  • Meiya Gao
  • Xinyu Yan
  • Rui Zhao
  • Yue Shan
  • Yiyin Chen
  • Fan Jian
  • Hu Long
  • Wenli Lai
  • Eur J Orthod.2020 Jul;cjaa037. doi: 10.1093/ejo/cjaa037.Epub 2020-07-02.

システイニル・ロイコトリエン受容体1遺伝子のメチル化は、交通関連の大気汚染にさらされた喘息患者の肺機能と関連している

Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution.
  • Nathan Rabinovitch
  • Meaghan J Jones
  • Nicole Gladish
  • Anna V Faino
  • Matthew Strand
  • Alexander M Morin
  • Julie MacIsaac
  • David T S Lin
  • Paul R Reynolds
  • Amrit Singh
  • Erwin W Gelfand
  • Michael S Kobor
  • Christopher Carlsten
  • Epigenetics.2020 Jul;:1-9. doi: 10.1080/15592294.2020.1790802.Epub 2020-07-12.

アピゲニンは、低酸素誘導因子1α-KV1.5チャネル経路の阻害を介してPASMCsのミトコンドリア依存性アポトーシスを誘導し、肺高血圧を抑制する

Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway.
  • Yuanzhou He
  • Xiaoyu Fang
  • Jing Shi
  • Xiaochen Li
  • Min Xie
  • Xiansheng Liu
  • Chem. Biol. Interact..2020 Feb;317:108942. S0009-2797(19)31491-7. doi: 10.1016/j.cbi.2020.108942.Epub 2020-01-10.

細胞外マトリックス蛋白質デコリンに由来する新規な化学走化因子は、in vitroおよびin vivoで間葉系間葉系間葉系細胞をリクルートする

A novel chemotactic factor derived from the extracellular matrix protein decorin recruits mesenchymal stromal cells in vitro and in vivo.
  • Sandi Grainne Dempsey
  • Christopher Hamilton Miller
  • Julia Schueler
  • Robert W F Veale
  • Darren J Day
  • Barnaby C H May
  • PLoS ONE.2020;15(7):e0235784. PONE-D-20-11853. doi: 10.1371/journal.pone.0235784.Epub 2020-07-13.

ニューハンプシャー出生コホート研究における出生前ヒ素曝露に関連した胎児胎盤の変化のトランスクリプトームワイド解析

Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study.
  • Emily F Winterbottom
  • Yuguang Ban
  • Xiaodian Sun
  • Anthony J Capobianco
  • Carmen J Marsit
  • Xi Chen
  • Lily Wang
  • Margaret R Karagas
  • David J Robbins
  • Environ Health.2019 11;18(1):100. 10.1186/s12940-019-0535-x. doi: 10.1186/s12940-019-0535-x.Epub 2019-11-21.

メチオニンエンケファリンはNFATc1の核内転座の制御を介して圧縮力によって誘導される骨細胞のアポトーシスを抑制する

Methionine Enkephalin Suppresses Osteocyte Apoptosis Induced by Compressive Force through Regulation of Nuclear Translocation of NFATc1.
  • Chisumi Sogi
  • Nobuo Takeshita
  • Wei Jiang
  • Siyoung Kim
  • Toshihiro Maeda
  • Michiko Yoshida
  • Toshihito Oyanagi
  • Arata Ito
  • Seiji Kimura
  • Daisuke Seki
  • Ikuko Takano
  • Yuichi Sakai
  • Ikuma Fujiwara
  • Shigeo Kure
  • Teruko Takano-Yamamoto
  • JBMR Plus.2020 Jul;4(7):e10369. JBM410369. doi: 10.1002/jbm4.10369.Epub 2020-05-26.

エビデンスに基づいたβ遮断薬の使用は、駆出率が低下した心不全で入院したメディケアの受益者において、心不全による再入院と死亡率の減少と関連しているが、全死因による再入院は減少していない

Evidence-based beta blocker use associated with lower heart failure readmission and mortality, but not all-cause readmission, among Medicare beneficiaries hospitalized for heart failure with reduced ejection fraction.
  • Matthew Shane Loop
  • Melissa K Van Dyke
  • Ligong Chen
  • Todd M Brown
  • Raegan W Durant
  • Monika M Safford
  • Emily B Levitan
  • PLoS ONE.2020;15(7):e0233161. PONE-D-19-24254. doi: 10.1371/journal.pone.0233161.Epub 2020-07-09.

膵頭十二指腸切除術患者における早期再入院と後期再入院。包括的なエピソディックコストを認識することで、バンドルされた支払い計画と病院の資源配分の指針となる

Early vs Late Readmissions in Pancreaticoduodenectomy Patients: Recognizing Comprehensive Episodic Cost to Help Guide Bundled Payment Plans and Hospital Resource Allocation.
  • Alexandra W Acher
  • James R Barrett
  • Patrick B Schwartz
  • Chris Stahl
  • Taylor Aiken
  • Sean Ronnekleiv-Kelly
  • Rebecca M Minter
  • Glen Leverson
  • Sharon Weber
  • Daniel E Abbott
  • J. Gastrointest. Surg..2020 Jul;10.1007/s11605-020-04714-3. doi: 10.1007/s11605-020-04714-3.Epub 2020-07-15.

腰椎ラジカル症を有する慢性腰痛患者における腰椎安定化運動プログラムと胸椎モビライゼーション運動プログラムの疼痛強度および機能障害の軽減に対する有効性。無作為化比較試験

Efficacy of the lumbar stabilization and thoracic mobilization exercise program on pain intensity and functional disability reduction in chronic low back pain patients with lumbar radiculopathy: A randomized controlled trial.
  • Stefan Kostadinović
  • Nenad Milovanović
  • Jelena Jovanović
  • Snežana Tomašević-Todorović
  • J Back Musculoskelet Rehabil.2020 Jul;BMR201843. doi: 10.3233/BMR-201843.Epub 2020-07-10.

CD47のアップレギュレーションは病原体認識に対する宿主チェックポイント応答である

Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition.
  • Michal Caspi Tal
  • Laughing Bear Torrez Dulgeroff
  • Lara Myers
  • Lamin B Cham
  • Katrin D Mayer-Barber
  • Andrea C Bohrer
  • Ehydel Castro
  • Ying Ying Yiu
  • Cesar Lopez Angel
  • Ed Pham
  • Aaron B Carmody
  • Ronald J Messer
  • Eric Gars
  • Jens Kortmann
  • Maxim Markovic
  • Michaela Hasenkrug
  • Karin E Peterson
  • Clayton W Winkler
  • Tyson A Woods
  • Paige Hansen
  • Sarah Galloway
  • Dhananjay Wagh
  • Benjamin J Fram
  • Thai Nguyen
  • Daniel Corey
  • Raja Sab Kalluru
  • Niaz Banaei
  • Jayakumar Rajadas
  • Denise M Monack
  • Aijaz Ahmed
  • Debashis Sahoo
  • Mark M Davis
  • Jeffrey S Glenn
  • Tom Adomati
  • Karl S Lang
  • Irving L Weissman
  • Kim J Hasenkrug
  • mBio.2020 06;11(3). e01293-20. doi: 10.1128/mBio.01293-20.Epub 2020-06-23.

非ST上昇型心筋梗塞における転帰の最適化を目的とした管理のためのフラクショナルフローリザーブと血管造影の比較：British Heart Foundation FAMOUS-NSTEMI無作為化試験

Fractional flow reserve vs. angiography in guiding management to optimize outcomes in non-ST-segment elevation myocardial infarction: the British Heart Foundation FAMOUS-NSTEMI randomized trial.
  • Jamie Layland
  • Keith G Oldroyd
  • Nick Curzen
  • Arvind Sood
  • Kanarath Balachandran
  • Raj Das
  • Shahid Junejo
  • Nadeem Ahmed
  • Matthew M Y Lee
  • Aadil Shaukat
  • Anna O'Donnell
  • Julian Nam
  • Andrew Briggs
  • Robert Henderson
  • Alex McConnachie
  • Colin Berry
  • Eur. Heart J..2015 Jan;36(2):100-11. ehu338. doi: 10.1093/eurheartj/ehu338.Epub 2014-09-01.

メキシコ、バハ・カリフォルニア州メヒカリ谷のコロラド川下流域におけるAs, Se, Hg, Pb, Cr及びトキサフェンに環境的に曝露された魚類の遺伝毒性

Genotoxicity in fishes environmentally exposed to As, Se, Hg, Pb, Cr and toxaphene in the lower Colorado River basin, at Mexicali valley, Baja California, México.
  • M A Flores-Galván
  • L W Daesslé
  • E Arellano-García
  • O Torres-Bugarín
  • J V Macías-Zamora
  • G Ruiz-Campos
  • Ecotoxicology.2020 May;29(4):493-502. 10.1007/s10646-020-02200-9. doi: 10.1007/s10646-020-02200-9.Epub 2020-04-14.

大量並列シーケンシングデータセットの解析により予測された、認知されていない内臓/神経学的晩期発症ニーマンピック病、C1型の高発生率

High incidence of unrecognized visceral/neurological late-onset Niemann-Pick disease, type C1, predicted by analysis of massively parallel sequencing data sets.
  • Christopher A Wassif
  • Joanna L Cross
  • James Iben
  • Luis Sanchez-Pulido
  • Antony Cougnoux
  • Frances M Platt
  • Daniel S Ory
  • Chris P Ponting
  • Joan E Bailey-Wilson
  • Leslie G Biesecker
  • Forbes D Porter
  • Genet. Med..2016 Jan;18(1):41-8. gim201525. doi: 10.1038/gim.2015.25.Epub 2015-03-12.

内在性アポトーシス経路の活性化は、腔内乳癌における抗エストロゲンに対する反応を増加させる

Intrinsic apoptotic pathway activation increases response to anti-estrogens in luminal breast cancers.
  • Michelle M Williams
  • Linus Lee
  • Thomas Werfel
  • Meghan M Morrison Joly
  • Donna J Hicks
  • Bushra Rahman
  • David Elion
  • Courtney McKernan
  • Violeta Sanchez
  • Monica V Estrada
  • Suleiman Massarweh
  • Richard Elledge
  • Craig Duvall
  • Rebecca S Cook
  • Cell Death Dis.2018 01;9(2):21. 10.1038/s41419-017-0072-x. doi: 10.1038/s41419-017-0072-x.Epub 2018-01-17.