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日本語AIでPubMedを検索

歯科医師情報サイトTOP / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
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2020年07月 みんなが読んでいる論文

急性統合失調症で入院し、外来診療に移行した患者さんを対象としたアリピプラゾール・ラウロキシルの2ヶ月間の1日投与製剤の有効性と安全性。第3相、無作為化、二重盲検、アクティブコントロールのALPINE試験

Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care: Phase 3, Randomized, Double-Blind, Active-Control ALPINE Study.
  • Peter J Weiden
  • Amy Claxton
  • Jelena Kunovac
  • David P Walling
  • Yangchun Du
  • Baiyun Yao
  • Sergey Yagoda
  • Ilda Bidollari
  • Elizabeth Keane
  • Ethan Cash
  • J Clin Psychiatry.2020 May;81(3). 19m13207. doi: 10.4088/JCP.19m13207.Epub 2020-05-19.

前頭側頭型認知症における脳脊髄液YKL-40およびチトトリオシダーゼレベルは、臨床的、遺伝的および病理学的サブタイプによって異なる

Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype.
  • Ione O C Woollacott
  • Jennifer M Nicholas
  • Carolin Heller
  • Martha S Foiani
  • Katrina M Moore
  • Lucy L Russell
  • Ross W Paterson
  • Ashvini Keshavan
  • Jonathan M Schott
  • Jason D Warren
  • Amanda Heslegrave
  • Henrik Zetterberg
  • Jonathan D Rohrer
  • Dement Geriatr Cogn Disord.2020 Apr;:1-21. 000506282. doi: 10.1159/000506282.Epub 2020-04-28.

淡水二枚貝 (Unionidae: Parreysiinae: Coelaturini) の多様化ダイナミクスは、東アフリカ地溝帯全体の歴史的な水路的なつながりを示している

Diversification dynamics of freshwater bivalves (Unionidae: Parreysiinae: Coelaturini) indicate historic hydrographic connections throughout the East African Rift System.
  • Claudia M Ortiz-Sepulveda
  • Björn Stelbrink
  • Xavier Vekemans
  • Christian Albrecht
  • Frank Riedel
  • Jonathan A Todd
  • Bert Van Bocxlaer
  • Mol. Phylogenet. Evol..2020 Jul;148:106816. S1055-7903(20)30088-9. doi: 10.1016/j.ympev.2020.106816.Epub 2020-04-11.

インターロイキン-1（IL-1）リガンドとその受容体の細胞特異的条件欠失：健康と疾患におけるIL-1の役割を研究するための新しいツールボックス

Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease.
  • Emmanuel Pinteaux
  • Wesam H Abdulaal
  • Ilgiz A Mufazalov
  • Neil E Humphreys
  • Maj Simonsen-Jackson
  • Sheila Francis
  • Werner Müller
  • Ari Waisman
  • J. Mol. Med..2020 Jul;98(7):923-930. 10.1007/s00109-020-01928-5. doi: 10.1007/s00109-020-01928-5.Epub 2020-05-29.

覚醒脳手術後のアプローチと転帰におけるモノリンガル患者とバイリンガル患者の違いの可能性

Potential differences between monolingual and bilingual patients in approach and outcome after awake brain surgery.
  • Karim ReFaey
  • Shashwat Tripathi
  • Adip G Bhargav
  • Sanjeet S Grewal
  • Erik H Middlebrooks
  • David S Sabsevitz
  • Mark Jentoft
  • Peter Brunner
  • Adela Wu
  • William O Tatum
  • Anthony Ritaccio
  • Kaisorn L Chaichana
  • Alfredo Quinones-Hinojosa
  • J. Neurooncol..2020 Jun;10.1007/s11060-020-03554-0. doi: 10.1007/s11060-020-03554-0.Epub 2020-06-10.

Bos taurus taurus と Bos taurus indicus の外陰部幅と肛門卵胞数が卵母細胞の質、体外胚産生、妊娠率に及ぼす影響

Effects of vulvar width and antral follicle count on oocyte quality, in vitro embryo production and pregnancy rate in Bos taurus taurus and Bos taurus indicus cows.
  • Gisvani Lopes de Vasconcelos
  • Ellen Vasconcelos da Cunha
  • Renata Maculan
  • Jesús Alfonso Sánchez Viafara
  • Anderson Weiny Barbalho Silva
  • Ana Liza Souza Batista
  • José Roberto Viana Silva
  • José Camisão de Souza
  • Anim. Reprod. Sci..2020 Jun;217:106357. S0378-4320(20)30229-3. doi: 10.1016/j.anireprosci.2020.106357.Epub 2020-04-27.

超音波照射によるイミダゾール異種環合成のためのベントナイトをベースとした新規かつグリーンなNiFeO/ジオポリマーナノ触媒の開発

Development of novel and green NiFeO/geopolymer nanocatalyst based on bentonite for synthesis of imidazole heterocycles by ultrasonic irradiations.
  • Zoleikha Hajizadeh
  • Fateme Radinekiyan
  • Reza Eivazzadeh-Keihan
  • Ali Maleki
  • Sci Rep.2020 Jul;10(1):11671. 10.1038/s41598-020-68426-z. doi: 10.1038/s41598-020-68426-z.Epub 2020-07-15.

RhoファミリーGTPasesの近接相互作用ネットワークをマッピングすることで、シグナル伝達経路と制御機構を明らかにした

Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
  • Halil Bagci
  • Neera Sriskandarajah
  • Amélie Robert
  • Jonathan Boulais
  • Islam E Elkholi
  • Viviane Tran
  • Zhen-Yuan Lin
  • Marie-Pier Thibault
  • Nadia Dubé
  • Denis Faubert
  • David R Hipfner
  • Anne-Claude Gingras
  • Jean-François Côté
  • Nat. Cell Biol..2020 01;22(1):120-134. 10.1038/s41556-019-0438-7. doi: 10.1038/s41556-019-0438-7.Epub 2019-12-23.

選択的後期ナトリウム電流阻害薬であるエレウテロシドBは、イソギンチャク毒素IIによりウサギの心臓に誘発される心房細動を抑制する

Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts.
  • Pei-Pei Zhang
  • Zhao-Fu Guo
  • Pei-Hua Zhang
  • Zhi-Pei Liu
  • Lv Song
  • Ze-Fu Zhang
  • Yu-Zhong Jia
  • Zhen-Zhen Cao
  • Ji-Hua Ma
  • Acta Pharmacol. Sin..2020 Jul;10.1038/s41401-020-0453-z. doi: 10.1038/s41401-020-0453-z.Epub 2020-07-01.

IGHV 配列決定により、濾胞性リンパ腫の進化の間にクローン性で安定したイベントとして後天的な N-グリコシル化部位が明らかになった

IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution.
  • Mariette Odabashian
  • Emanuela Carlotti
  • Shamzah Araf
  • Jessica Okosun
  • Filomena Spada
  • John G Gribben
  • Francesco Forconi
  • Freda K Stevenson
  • Mariarita Calaminici
  • Sergey Krysov
  • Blood.2020 Mar;135(11):834-844. 430246. doi: 10.1182/blood.2019002279.

頭頸部がん患者の放射線治療計画のワンストップショップとしてのマルチパラメトリックPET/MRIの有用性

Feasibility of multiparametric PET/MRI as a one-stop-shop for radiotherapy planning of head and neck cancer patients.
  • Anders B Olin
  • Adam E Hansen
  • Jacob H Rasmussen
  • Claes N Ladefoged
  • Anne K Berthelsen
  • Katrin Håkansson
  • Ivan R Vogelius
  • Lena Specht
  • Anita B Gothelf
  • Andreas Kjaer
  • Barbara M Fischer
  • Flemming L Andersen
  • Int. J. Radiat. Oncol. Biol. Phys..2020 Jul;S0360-3016(20)31422-X. doi: 10.1016/j.ijrobp.2020.07.024.Epub 2020-07-16.

特発性小児高カルシウム血症の改善されたスクリーニング検査で、影響を受けた患者の血清24,25-(OH)Dの残存濃度が確認される

Improved Screening Test for Idiopathic Infantile Hypercalcemia Confirms Residual Levels of Serum 24,25-(OH) D in Affected Patients.
  • Martin Kaufmann
  • Nicole Morse
  • Billy Joe Molloy
  • Donald P Cooper
  • Karl Peter Schlingmann
  • Arnaud Molin
  • Marie Laure Kottler
  • J Christopher Gallagher
  • Laura Armas
  • Glenville Jones
  • J. Bone Miner. Res..2017 Jul;32(7):1589-1596. doi: 10.1002/jbmr.3135.Epub 2017-04-21.

ヒトの飲料水資源中に存在する化合物および混合物のステロイドおよびアリール炭化水素受容体に影響を与える潜在的な内分泌撹乱活性のインビトロプロファイリング

In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources.
  • Doan Tq
  • Connolly L
  • Igout A
  • Nott K
  • Muller M
  • Scippo Ml
  • Chemosphere.2020 Jun;258:127332. S0045-6535(20)31525-3. doi: 10.1016/j.chemosphere.2020.127332.Epub 2020-06-09.

16S rRNA 遺伝子に基づくメタゲノム解析により、地球規模の大量白化がサンゴのマイクロバイオームに与える影響を明らかにした

Revealing the impact of global mass bleaching on coral microbiome through 16S rRNA gene-based metagenomic analysis.
  • Ramu Meenatchi
  • Thangadurai Thinesh
  • Pownraj Brindangnanam
  • Saqib Hassan
  • George Seghal Kiran
  • Joseph Selvin
  • Microbiol. Res..2020 Mar;233:126408. S0944-5013(19)31312-6. doi: 10.1016/j.micres.2019.126408.Epub 2019-12-31.

オープンマイクロ流体共培養は、ヒト腎臓上皮細胞からのパラクリンシグナルを明らかに内皮細胞の腎臓特異性を促進する

Open microfluidic coculture reveals paracrine signaling from human kidney epithelial cells promotes kidney specificity of endothelial cells.
  • Tianzi Zhang
  • Daniel Lih
  • Ryan J Nagao
  • Jun Xue
  • Erwin Berthier
  • Jonathan Himmelfarb
  • Ying Zheng
  • Ashleigh B Theberge
  • Am. J. Physiol. Renal Physiol..2020 Jul;319(1):F41-F51. doi: 10.1152/ajprenal.00069.2020.Epub 2020-05-11.

BRAF(V600E)変異を有する甲状腺癌細胞において、過剰なオートファジーを制御することにより、HMGB1がベムラフェニブ抵抗性に関与していることを明らかにした

Involvement of HMGB1 in vemurafenib resistance in thyroid cancer cells harboring BRAF (V600E) mutation by regulating excessive autophagy.
  • Lin Run
  • Liping Wang
  • Xiting Nong
  • Nan Li
  • Xin Huang
  • Yang Xiao
  • Endocrine.2020 Jul;10.1007/s12020-020-02417-y. doi: 10.1007/s12020-020-02417-y.Epub 2020-07-14.

TM4細胞におけるZEA誘導オートファジーは、Caの放出が小胞体におけるCaMKKβ-AMPKシグナル伝達経路を活性化することを介して誘導された

ZEA-induced autophagy in TM4 cells was mediated by the release of Ca activates CaMKKβ-AMPK signaling pathway in the endoplasmic reticulum.
  • Nannan Feng
  • Bingjie Wang
  • Peirong Cai
  • Wanglong Zheng
  • Hui Zou
  • Jianhong Gu
  • Yan Yuan
  • Xuezhong Liu
  • ZongPing Liu
  • Jianchun Bian
  • Toxicol. Lett..2020 May;323:1-9. S0378-4274(20)30018-7. doi: 10.1016/j.toxlet.2020.01.010.Epub 2020-01-23.

Mimachlamys variaのメタロチオネインはフランス大西洋沿岸海域の微量元素のバイオマーカーに適しているか？

Is metallothionein in Mimachlamys varia a suitable biomarker of trace elements in the waters of the French Atlantic coast?
  • Marine Breitwieser
  • Mélanie Bruneau
  • Marine Barbarin
  • Carine Churlaud
  • Catherine Mouneyrac
  • Hélène Thomas
  • Environ Sci Pollut Res Int.2020 Jun;27(16):20259-20272. 10.1007/s11356-020-08392-1. doi: 10.1007/s11356-020-08392-1.Epub 2020-04-02.

プロテオミクスによるプロファイリングでは、インスリン様成長因子1、コラーゲンVI型α-2鎖、フェルミチンファミリーホモログ3が、STセグメント上昇型心筋梗塞におけるプラーク侵食のバイオマーカーとなる可能性があることが明らかになった

Proteomics Profiling Reveals Insulin-Like Growth Factor 1, Collagen Type VI α-2 Chain, and Fermitin Family Homolog 3 as Potential Biomarkers of Plaque Erosion in ST-Segment Elevated Myocardial Infarction.
  • Jinxin Liu
  • Shanjie Wang
  • Jingbo Hou
  • Hengxuan Cai
  • Weili Pan
  • Haimeng Dong
  • Rong Sun
  • Hui Dong
  • Shaohong Fang
  • Bo Yu
  • Circ. J..2020 May;84(6):985-993. doi: 10.1253/circj.CJ-19-1206.Epub 2020-04-29.

シンガポールでのSARS-CoV-2発生時の個人用保護具（PPE）利用に及ぼすN95呼吸器の長時間使用と目の保護の影響

Effect of extended use N95 respirators and eye protection on personal protective equipment (PPE) utilization during SARS-CoV-2 outbreak in Singapore.
  • Glorijoy Shi En Tan
  • Kyaw Zaw Linn
  • Margaret Mei Ling Soon
  • Shawn Vasoo
  • Monica Chan
  • Bee Fong Poh
  • Oon-Tek Ng
  • Brenda Sze-Peng Ang
  • Yee-Sin Leo
  • Kalisvar Marimuthu
  • Antimicrob Resist Infect Control.2020 06;9(1):86. 10.1186/s13756-020-00753-2. doi: 10.1186/s13756-020-00753-2.Epub 2020-06-15.

COVID-19を有する成人患者における肝障害のパターン：105人の患者を対象にしたレトロスペクティブ解析

Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients.
  • Qi Wang
  • Hong Zhao
  • Li-Gai Liu
  • Yan-Bin Wang
  • Ting Zhang
  • Ming-Hui Li
  • Yan-Li Xu
  • Gui-Ju Gao
  • Hao-Feng Xiong
  • Ying Fan
  • Ying Cao
  • Rui Ding
  • Jing-Jing Wang
  • Cheng Cheng
  • Wen Xie
  • Mil Med Res.2020 06;7(1):28. 10.1186/s40779-020-00256-6. doi: 10.1186/s40779-020-00256-6.Epub 2020-06-07.

外来患者のメンタルヘルスにおける包括的な薬物療法管理における薬物選択と投与の指針として、ファーマコゲノミクスと治療薬モニタリングを使用しています

Using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management.
  • Jacob T Brown
  • Jeffrey R Bishop
  • Mark E Schneiderhan
  • Ment Health Clin.2020 Jul;10(4):254-258. MHC-D-19-00043. doi: 10.9740/mhc.2020.07.254.Epub 2020-07-02.

低所得国および中所得国の生後 2～60 ヵ月の小児における補助的肺炎治療としての亜鉛の有効性：システマティックレビューおよびメタアナリシス

Efficacy of zinc as adjunctive pneumonia treatment in children aged 2 to 60 months in low-income and middle-income countries: a systematic review and meta-analysis.
  • Nick Brown
  • Antti Juhani Kukka
  • Andreas Mårtensson
  • BMJ Paediatr Open.2020;4(1):e000662. bmjpo-2020-000662. doi: 10.1136/bmjpo-2020-000662.Epub 2020-07-12.

近接拡張アッセイによるアルツハイマー病の血液由来細胞外ベシクルベースの新規バイオマーカーの同定

Novel Blood-Derived Extracellular Vesicle-Based Biomarkers in Alzheimer's Disease Identified by Proximity Extension Assay.
  • Jonas Ellegaard Nielsen
  • Kamilla Sofie Pedersen
  • Karsten Vestergård
  • Raluca Georgiana Maltesen
  • Gunna Christiansen
  • Søren Lundbye-Christensen
  • Torben Moos
  • Søren Risom Kristensen
  • Shona Pedersen
  • Biomedicines.2020 Jul;8(7). E199. doi: 10.3390/biomedicines8070199.Epub 2020-07-07.

VLCAD欠損心筋細胞の電気生理学的異常は脂肪酸酸化中間体の蓄積を低下させることで改善される可能性がある

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates.
  • Suzan J G Knottnerus
  • Isabella Mengarelli
  • Rob C I Wüst
  • Antonius Baartscheer
  • Jeannette C Bleeker
  • Ruben Coronel
  • Sacha Ferdinandusse
  • Kaomei Guan
  • Lodewijk IJlst
  • Wener Li
  • Xiaojing Luo
  • Vincent M Portero
  • Ying Ulbricht
  • Gepke Visser
  • Ronald J A Wanders
  • Frits A Wijburg
  • Arie O Verkerk
  • Riekelt H Houtkooper
  • Connie R Bezzina
  • Int J Mol Sci.2020 Apr;21(7). E2589. doi: 10.3390/ijms21072589.Epub 2020-04-08.

Fragile X精神遅滞タンパク質は、マウスの海馬と前頭前野の間で、細胞型特異的な方法で樹状突起Iを双方向に制御している

Fragile X Mental Retardation Protein Bidirectionally Controls Dendritic I in a Cell Type-Specific Manner between Mouse Hippocampus and Prefrontal Cortex.
  • Federico Brandalise
  • Brian E Kalmbach
  • Preeti Mehta
  • Olivia Thornton
  • Daniel Johnston
  • Boris V Zemelman
  • Darrin H Brager
  • J. Neurosci..2020 Jul;40(27):5327-5340. JNEUROSCI.1670-19.2020. doi: 10.1523/JNEUROSCI.1670-19.2020.Epub 2020-05-28.

3つの症候と3つの方法」に基づいた漢方薬によるコロナウイルス病2019の診断と治療に関する専門家の見解

[Expert opinion on diagnosis and treatment of coronavirus disease 2019 with traditional Chinese medicine based on "three syndromes and three methods"].
  • Committee China Association Of Integrative Medicine Emergency Medicine
  • Medicine Editorial Committee Of Chinese Journal Of Integrated Traditional And Western
  • Zhonghua Wei Zhong Bing Ji Jiu Yi Xue.2020 Jun;32(6):641-645. doi: 10.3760/cma.j.cn121430-20200529-00476.

子宮異常出血に対するRubia cordifolia L.の4つの成分の同時測定とシステマティックな薬理学的アプローチによる実験的検証により、子宮異常出血のメカニズムとその物質的基盤を明らかにした

Revealing the mechanisms and the material basis of Rubia cordifolia L. on abnormal uterine bleeding with uniting simultaneous determination of four components and systematic pharmacology approach-experimental validation.
  • Kan Wang
  • Lan Gao
  • Qiao Zhang
  • Yi Zhang
  • Weifeng Yao
  • Min Zhang
  • Yuping Tang
  • Anwei Ding
  • Li Zhang
  • J Pharm Biomed Anal.2020 Jul;189:113475. S0731-7085(20)31361-3. doi: 10.1016/j.jpba.2020.113475.Epub 2020-07-15.

前十字靭帯再建術におけるハムストリングス腱ハーベスティングと伏在神経内包枝損傷における斜め切開と垂直切開の比較

A Comparison between Oblique and Vertical Incisions on the Hamstring Tendon Harvesting in Anterior Cruciate Ligament Reconstruction and Infrapatellar Branch Injury of the Saphenous Nerve.
  • Sohrab Keyhani
  • Seyyed Morteza Kazemi
  • Mohammadreza Minator Sajjadi
  • Asghar Elmi
  • Rev Bras Ortop (Sao Paulo).2020 Jun;55(3):374-379. 1900043pt. doi: 10.1055/s-0039-1692695.Epub 2019-08-27.

従属栄養性の硫化物酸化硝酸還元菌を用いることで、高硫化物負荷下での統合自己栄養-従属栄養脱窒(IAHD)プロセスの高性能化を可能にした

Heterotrophic sulfide-oxidizing nitrate-reducing bacteria enables the high performance of integrated autotrophic-heterotrophic denitrification (IAHD) process under high sulfide loading.
  • Ruo-Chen Zhang
  • Chuan Chen
  • Bo Shao
  • Wei Wang
  • Xi-Jun Xu
  • Xu Zhou
  • Yu-Nong Xiang
  • Lei Zhao
  • Duu-Jong Lee
  • Nan-Qi Ren
  • Water Res..2020 Jul;178:115848. S0043-1354(20)30385-7. doi: 10.1016/j.watres.2020.115848.Epub 2020-04-21.

プロのロッククライマーにおけるオーダーメイドのタロナビキュラー全置換術。歩行分析と3Dメディカルイメージングを用いた機能評価と5年後の追跡調査での体重負荷時の機能評価

Custom-Made Total Talonavicular Replacement in a Professional Rock Climber: Functional Evaluation With Gait Analysis and 3-Dimensional Medical Imaging in Weightbearing at 5 Years' Follow-Up.
  • Giada Lullini
  • Claudio Belvedere
  • Maurizio Ortolani
  • Silvia Ruzzi
  • Antonio Mazzotti
  • Alberto Leardini
  • J Foot Ankle Surg.2020 Jul;S1067-2516(20)30179-4. doi: 10.1053/j.jfas.2020.05.005.Epub 2020-07-16.

前十字靭帯再建のためには、ハムストリングス自家移植よりも四半規管腱鎖自家移植の方が良い選択か？平均追跡期間3年の比較研究

Is quadruple semitendinosus tendon strands autograft a better choice than hamstring autograft for anterior cruciate ligament reconstruction? A comparative study with a mean follow-up of 3 years.
  • Stéphane Plaweski
  • Hubert Lanternier
  • Eur J Orthop Surg Traumatol.2020 Jul;10.1007/s00590-020-02729-9. doi: 10.1007/s00590-020-02729-9.Epub 2020-07-02.

α7ニコチン性アセチルコリン受容体のサイレントアゴニストは、ex vivoで炎症を調節し、EAEを減衰させる

A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE.
  • Jean-Rémi Godin
  • Patrick Roy
  • Marta Quadri
  • Deniz Bagdas
  • Wisam Toma
  • Ramya Narendrula-Kotha
  • Osama A Kishta
  • M Imad Damaj
  • Nicole A Horenstein
  • Roger L Papke
  • Alain R Simard
  • Brain Behav. Immun..2020 Jul;87:286-300. S0889-1591(19)31074-8. doi: 10.1016/j.bbi.2019.12.014.Epub 2019-12-23.

トポロジー的に関連づけられたドメインは、体細胞性超変異に対する感受性を規定する

Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation.
  • Filip Senigl
  • Yaakov Maman
  • Ravi K Dinesh
  • Jukka Alinikula
  • Rashu B Seth
  • Lubomira Pecnova
  • Arina D Omer
  • Suhas S P Rao
  • David Weisz
  • Jean-Marie Buerstedde
  • Erez Lieberman Aiden
  • Rafael Casellas
  • Jiri Hejnar
  • David G Schatz
  • Cell Rep.2019 12;29(12):3902-3915.e8. S2211-1247(19)31521-9. doi: 10.1016/j.celrep.2019.11.039.

ヒトアンジオテンシノーゲン遺伝子()のイントロンIの多型は、HNF3の結合と発現に影響を与え、マウスの血圧を上昇させる

A polymorphism in intron I of the human angiotensinogen gene () affects binding by HNF3 and expression and increases blood pressure in mice.
  • Brahmaraju Mopidevi
  • Meenakshi K Kaw
  • Indu Sivankutty
  • Sudhir Jain
  • Sravan Kumar Perla
  • Ashok Kumar
  • J. Biol. Chem..2019 08;294(31):11829-11839. RA119.007715. doi: 10.1074/jbc.RA119.007715.Epub 2019-06-14.

アニリンが高濃度硫酸廃水の嫌気性処理における微生物群集と生物学的硫酸還元経路に及ぼす影響についてのメタゲノム解析の知見が得られた

Metagenomic insights into aniline effects on microbial community and biological sulfate reduction pathways during anaerobic treatment of high-sulfate wastewater.
  • Jun Li
  • Ying Liang
  • Yu Miao
  • Depeng Wang
  • Shuyu Jia
  • Chang-Hong Liu
  • Sci. Total Environ..2020 Jun;742:140537. S0048-9697(20)34059-6. doi: 10.1016/j.scitotenv.2020.140537.Epub 2020-06-28.

カルコゲナイド表面の化学的不安定性は、カルコパイライトデバイスの表面をはるかに超えて影響を与えます

Chemical instability at chalcogenide surfaces impacts chalcopyrite devices well beyond the surface.
  • Diego Colombara
  • Hossam Elanzeery
  • Nicoleta Nicoara
  • Deepanjan Sharma
  • Marcel Claro
  • Torsten Schwarz
  • Anna Koprek
  • Max Hilaire Wolter
  • Michele Melchiorre
  • Mohit Sood
  • Nathalie Valle
  • Oleksandr Bondarchuk
  • Finn Babbe
  • Conrad Spindler
  • Oana Cojocaru-Miredin
  • Dierk Raabe
  • Phillip J Dale
  • Sascha Sadewasser
  • Susanne Siebentritt
  • Nat Commun.2020 Jul;11(1):3634. 10.1038/s41467-020-17434-8. doi: 10.1038/s41467-020-17434-8.Epub 2020-07-20.

前方勾配2は、CCAAT-エンハンサー結合タンパク質βと低酸素誘導性因子-2αのアップレギュレーションと、それに続くインターロイキン-6、インターロイキン-8、血管内皮増殖因子の分泌を介して腫瘍形成を促進することを明らかにした

Anterior gradient 2 promotes tumorigenesis through upregulation of CCAAT-enhancer binding protein beta and hypoxia-inducible factor-2α and subsequent secretion of interleukin-6, interleukin-8, and vascular endothelial growth factor in the Caki-1 clear cell renal cell carcinoma cell line.
  • Kinga Pajdzik
  • Mateusz Wilamowski
  • Dariusz Żurawek
  • Kinga B Stopa
  • Michał Nodzyński
  • Agata Kalita
  • Jolanta Jura
  • IUBMB Life.2020 Jun;doi: 10.1002/iub.2331.Epub 2020-06-27.

長距離フライトのトイレ排泄物に含まれるウイルスのメタゲノム解析-世界的な感染症サーベイランスのための新しい手順

Metagenomic analysis of viruses in toilet waste from long distance flights-A new procedure for global infectious disease surveillance.
  • Mathis Hjort Hjelmsø
  • Sarah Mollerup
  • Randi Holm Jensen
  • Carlotta Pietroni
  • Oksana Lukjancenko
  • Anna Charlotte Schultz
  • Frank M Aarestrup
  • Anders Johannes Hansen
  • PLoS ONE.2019;14(1):e0210368. PONE-D-18-25424. doi: 10.1371/journal.pone.0210368.Epub 2019-01-14.

ゲノムワイドアソシエーション研究を用いたヒト血漿N-グリコームの遺伝的制御の定義

Defining the genetic control of human blood plasma N-glycome using genome-wide association study.
  • Sodbo Zh Sharapov
  • Yakov A Tsepilov
  • Lucija Klaric
  • Massimo Mangino
  • Gaurav Thareja
  • Alexandra S Shadrina
  • Mirna Simurina
  • Concetta Dagostino
  • Julia Dmitrieva
  • Marija Vilaj
  • Frano Vuckovic
  • Tamara Pavic
  • Jerko Stambuk
  • Irena Trbojevic-Akmacic
  • Jasminka Kristic
  • Jelena Simunovic
  • Ana Momcilovic
  • Harry Campbell
  • Margaret Doherty
  • Malcolm G Dunlop
  • Susan M Farrington
  • Maja Pucic-Bakovic
  • Christian Gieger
  • Massimo Allegri
  • Edouard Louis
  • Michel Georges
  • Karsten Suhre
  • Tim Spector
  • Frances M K Williams
  • Gordan Lauc
  • Yurii S Aulchenko
  • Hum. Mol. Genet..2019 06;28(12):2062-2077. 5374524. doi: 10.1093/hmg/ddz054.

ミトコンドリアの機能活性とアクチン細胞骨格の不安定性との関連について

Association Between Functional Activity of Mitochondria and Actin Cytoskeleton Instability in Oocytes from Advanced Age Mice.
  • Myung Joo Kim
  • Kyoung Hee Choi
  • Dong Woo Seo
  • Hye Ran Lee
  • Hyun Seok Kong
  • Chan Hee Lee
  • Woo Sik Lee
  • Hoon Taek Lee
  • Jung Jae Ko
  • Ji Hyang Kim
  • Sang Jin Lee
  • Jae Ho Lee
  • Reprod Sci.2020 04;27(4):1037-1046. 10.1007/s43032-020-00145-2. doi: 10.1007/s43032-020-00145-2.Epub 2020-02-05.

慢性免疫介在性炎症性リウマチ性疾患患者に対するヒドロキシクロロキンとクロロキンの再検討

Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases.
  • Edgard Torres Dos Reis Neto
  • Adriana Maria Kakehasi
  • Marcelo de Medeiros Pinheiro
  • Gilda Aparecida Ferreira
  • Cláudia Diniz Lopes Marques
  • Licia Maria Henrique da Mota
  • Eduardo Dos Santos Paiva
  • Gecilmara Cristina Salviato Pileggi
  • Emília Inoue Sato
  • Ana Paula Monteiro Gomides Reis
  • Ricardo Machado Xavier
  • José Roberto Provenza
  • Adv Rheumatol.2020 06;60(1):32. 10.1186/s42358-020-00134-8. doi: 10.1186/s42358-020-00134-8.Epub 2020-06-09.

再発・難治性多発性骨髄腫患者を対象とした新規抗CD38モノクローナル抗体「MOR202」：第1-2a相臨床試験（第1-2a相、多施設共同、ヒト初）

MOR202, a novel anti-CD38 monoclonal antibody, in patients with relapsed or refractory multiple myeloma: a first-in-human, multicentre, phase 1-2a trial.
  • Marc S Raab
  • Monika Engelhardt
  • Antje Blank
  • Hartmut Goldschmidt
  • Hermine Agis
  • Igor W Blau
  • Hermann Einsele
  • Barbara Ferstl
  • Natalie Schub
  • Christoph Röllig
  • Katja Weisel
  • Mark Winderlich
  • Janine Griese
  • Stefan Härtle
  • Johannes Weirather
  • Tiantom Jarutat
  • Christian Peschel
  • Manik Chatterjee
  • Lancet Haematol.2020 May;7(5):e381-e394. S2352-3026(19)30249-2. doi: 10.1016/S2352-3026(19)30249-2.Epub 2020-03-11.

腸内微生物叢および未消化の食品成分は、毒素の組成を変更し、in vitroで天然に存在するカビの毒素混合物の遺伝毒性を抑制する

Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro.
  • Francesco Crudo
  • Georg Aichinger
  • Jovana Mihajlovic
  • Luca Dellafiora
  • Elisabeth Varga
  • Hannes Puntscher
  • Benedikt Warth
  • Chiara Dall'Asta
  • David Berry
  • Doris Marko
  • Arch. Toxicol..2020 Jul;10.1007/s00204-020-02831-1. doi: 10.1007/s00204-020-02831-1.Epub 2020-07-04.

臨床的に安定した統合失調症患者を対象としたパルミチン酸パリペリドン3ヵ月間製剤の52週間投与後の症状および機能的転帰

Symptomatic and functional outcomes after treatment with paliperidone palmitate 3-month formulation for 52 weeks in patients with clinically stable schizophrenia.
  • Maria Paz Garcia-Portilla
  • Pierre-Michel Llorca
  • Giuseppe Maina
  • Vasilis P Bozikas
  • Halise Devrimci-Ozguven
  • Sung-Wan Kim
  • Paul Bergmans
  • Irina Usankova
  • Katalin Pungor
  • Ther Adv Psychopharmacol.2020;10:2045125320926347. 10.1177_2045125320926347. doi: 10.1177/2045125320926347.Epub 2020-05-25.

イタリアの先天的な生まれと移民の母親の早産児の神経発達の軌跡と新生児給餌の役割

Neurodevelopmental Trajectories of Preterm Infants of Italian Native-Born and Migrant Mothers and Role of Neonatal Feeding.
  • Dino Gibertoni
  • Alessandra Sansavini
  • Silvia Savini
  • Chiara Locatelli
  • Gina Ancora
  • Enrica Perrone
  • Magda Ialonardi
  • Paola Rucci
  • Maria Pia Fantini
  • Giacomo Faldella
  • Luigi Corvaglia
  • Int J Environ Res Public Health.2020 Jun;17(12). E4588. doi: 10.3390/ijerph17124588.Epub 2020-06-25.

工業的に汚染されたサイトに関連した健康影響の疫学研究のための暴露評価方法のレビュー

A review of exposure assessment methods for epidemiological studies of health effects related to industrially contaminated sites.
  • Gerard Hoek
  • Andrea Ranzi
  • Ilir Alimehmeti
  • Elena-Roxana Ardeleanu
  • Juan P Arrebola
  • Paula Ávila
  • Carla Candeias
  • Ann Colles
  • Gloria Cerasela Crișan
  • Sarah Dack
  • Zoltán Demeter
  • Lucia Fazzo
  • Tine Fierens
  • Benjamin Flückiger
  • Stephanie Gaengler
  • Otto Hänninen
  • Hedi Harzia
  • Rupert Hough
  • Barna Laszlo Iantovics
  • Olga-Ioanna Kalantzi
  • Spyros P Karakitsios
  • Konstantinos C Markis
  • Piedad Martin-Olmedo
  • Elena Nechita
  • Thomai Nicoli
  • Hans Orru
  • Roberto Pasetto
  • Francisco Miguel Pérez-Carrascosa
  • Diogo Pestana
  • Fernando Rocha
  • Dimosthenis A Sarigiannis
  • João Paulo Teixeira
  • Christos Tsadilas
  • Visa Tasic
  • Lorenzo Vaccari
  • Ivano Iavarone
  • Kees de Hoogh
  • Epidemiol Prev.2018 Sep-Dec;42(5-6S1):21-36. 4179. doi: 10.19191/EP18.5-6.S1.P021.085.

腸球菌フェシウムのゲノムサーベイランスにより、英国における家畜とヒトの間での耐性遺伝子の共有は限られていることが明らかになった

Genomic Surveillance of Enterococcus faecium Reveals Limited Sharing of Strains and Resistance Genes between Livestock and Humans in the United Kingdom.
  • Theodore Gouliouris
  • Kathy E Raven
  • Catherine Ludden
  • Beth Blane
  • Jukka Corander
  • Carolyne S Horner
  • Juan Hernandez-Garcia
  • Paul Wood
  • Nazreen F Hadjirin
  • Milorad Radakovic
  • Mark A Holmes
  • Marcus de Goffau
  • Nicholas M Brown
  • Julian Parkhill
  • Sharon J Peacock
  • mBio.2018 11;9(6). e01780-18. doi: 10.1128/mBio.01780-18.Epub 2018-11-06.

プロテインチロシンホスファターゼ受容体Jの膜貫通ドメインを介したオリゴマー化を阻害することで、EGFR駆動の癌細胞の表現型を抑制することができた

Disrupting the transmembrane domain-mediated oligomerization of protein tyrosine phosphatase receptor J inhibits EGFR-driven cancer cell phenotypes.
  • Elizabeth Bloch
  • Eden L Sikorski
  • David Pontoriero
  • Evan K Day
  • Bryan W Berger
  • Matthew J Lazzara
  • Damien Thévenin
  • J. Biol. Chem..2019 12;294(49):18796-18806. RA119.010229. doi: 10.1074/jbc.RA119.010229.Epub 2019-11-01.

ラットの腫瘍発生と癌の悪液質は、アポトーシスを増加させ、代謝プロファイルを改善することにより、ボトリョスファエランによる治療により減少した

Tumor development in rats and cancer cachexia are reduced by treatment with botryosphaeran by increasing apoptosis and improving the metabolic profile.
  • Danielli Geraldelli
  • Mariana C Ribeiro
  • Túlio C Medeiros
  • Patricia K Comiran
  • Kamila O Martins
  • Matheus F Oliveira
  • Gabriela A Oliveira
  • Robert F H Dekker
  • Aneli M Barbosa-Dekker
  • Pâmela Alegranci
  • Eveline A I F Queiroz
  • Life Sci..2020 Jul;252:117608. S0024-3205(20)30356-8. doi: 10.1016/j.lfs.2020.117608.Epub 2020-04-11.

懸念される発現。E3ユビキチンリガーゼのニューレグリン受容体分解タンパク質1（Nrdp1）は、転写因子CCAAT/エンハンサー結合タンパク質β（C/EBPβ）をユビキチン化して活性化することにより、M2マクロファージの分極を促進する

Expression of Concern: The E3 ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) promotes M2 macrophage polarization by ubiquitinating and activating transcription factor CCAAT/enhancer-binding protein β (C/EBPβ).
  • J. Biol. Chem..2020 06;295(26):8884. 295/26/8884. doi: 10.1074/jbc.EC120.014571.

歯周維持療法中の口腔内バイオフィルムに対するトレハロース粉末を用いた歯肉下エアポリッシングの効果：無作為化対照パイロット試験

Effects of subgingival air-polishing with trehalose powder on oral biofilm during periodontal maintenance therapy: a randomized-controlled pilot study.
  • Anne B Kruse
  • Rabie Maamar
  • Dodji L Akakpo
  • Johan P Woelber
  • Annette Wittmer
  • Kirstin Vach
  • Petra Ratka-Krüger
  • Ali Al-Ahmad
  • BMC Oral Health.2020 Apr;20(1):123. 10.1186/s12903-020-01111-9. doi: 10.1186/s12903-020-01111-9.Epub 2020-04-22.

タイ産ジャスミンイネ（Oryza sativa L. ssp. indica cv. KDML105）由来のアルド-ケト還元酵素AKR4C14の構造機能研究

Structure-function study of AKR4C14, an aldo-keto reductase from Thai jasmine rice (Oryza sativa L. ssp. indica cv. KDML105).
  • Chomphunuch Songsiriritthigul
  • Rawint Narawongsanont
  • Chonticha Tantitadapitak
  • Hong Hsiang Guan
  • Chun Jung Chen
  • Acta Crystallogr D Struct Biol.2020 May;76(Pt 5):472-483. S2059798320004313. doi: 10.1107/S2059798320004313.Epub 2020-04-23.

ガーナからの子供たちの急性栄養失調を治療するための標準よりも、代替のすぐに使える治療用食品の方が少ない回復をもたらす

Alternative Ready-To-Use Therapeutic Food Yields Less Recovery Than the Standard for Treating Acute Malnutrition in Children From Ghana.
  • Kristin Kohlmann
  • Meghan Callaghan-Gillespie
  • Julia M Gauglitz
  • Matilda Steiner-Asiedu
  • Kwesi Saalia
  • Carly Edwards
  • Mark J Manary
  • Glob Health Sci Pract.2019 06;7(2):203-214. GHSP-D-19-00004. doi: 10.9745/GHSP-D-19-00004.Epub 2019-06-27.

交感神経系のニコチン性アセチルコリン受容体を介したニトロ刺激性神経原性拡張に対するドネペジルとヒューパジンAの差異遮断作用

Differential blockade by huperzine A and donepezil of sympathetic nicotinic acetylcholine receptor-mediated nitrergic neurogenic dilations in porcine basilar arteries.
  • Cheng-Chan Shih
  • Po-Yi Chen
  • Mei-Fang Chen
  • Tony J F Lee
  • Eur. J. Pharmacol..2020 Feb;868:172851. S0014-2999(19)30803-9. doi: 10.1016/j.ejphar.2019.172851.Epub 2019-12-10.

A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human Beings

A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human Beings.
  • Veronika Voronova
  • Victor Sokolov
  • Amani Al-Khaifi
  • Sara Straniero
  • Chanchal Kumar
  • Kirill Peskov
  • Gabriel Helmlinger
  • Mats Rudling
  • Bo Angelin
  • Cell Mol Gastroenterol Hepatol.2020;10(1):149-170. S2352-345X(20)30026-6. doi: 10.1016/j.jcmgh.2020.02.005.Epub 2020-02-26.

単細胞トランスクリプトームにより、CD44が内皮から造血への移行のマーカーと調節因子であることが明らかになった

Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
  • Morgan Oatley
  • Özge Vargel Bölükbası
  • Valentine Svensson
  • Maya Shvartsman
  • Kerstin Ganter
  • Katharina Zirngibl
  • Polina V Pavlovich
  • Vladislava Milchevskaya
  • Vladimira Foteva
  • Kedar N Natarajan
  • Bianka Baying
  • Vladimir Benes
  • Kiran R Patil
  • Sarah A Teichmann
  • Christophe Lancrin
  • Nat Commun.2020 Jan;11(1):586. 10.1038/s41467-019-14171-5. doi: 10.1038/s41467-019-14171-5.Epub 2020-01-29.

大腸菌W.のバッチ培養および連続培養におけるアセチル化に鈍感なアセチル-CoA合成酵素の発現がグルコースとアセテートの共利用に及ぼす影響の解析

Characterizing the effect of expression of an acetyl-CoA synthetase insensitive to acetylation on co-utilization of glucose and acetate in batch and continuous cultures of E. coli W.
  • Katharina Novak
  • Lukas Flöckner
  • Anna Maria Erian
  • Philipp Freitag
  • Christoph Herwig
  • Stefan Pflügl
  • Microb. Cell Fact..2018 Jul;17(1):109. 10.1186/s12934-018-0955-2. doi: 10.1186/s12934-018-0955-2.Epub 2018-07-09.

ブラジルにおける予防接種情報システムの使い勝手の評価．混合法による研究

Evaluation of the Usability of the Immunization Information System in Brazil: A Mixed-Method Study.
  • Eliete Albano de Azevedo Guimarães
  • Ygor Colen Morato
  • Dárlinton Barbosa Feres Carvalho
  • Valéria Conceição de Oliveira
  • Victor Matheus Sanches Pivatti
  • Ricardo Bezerra Cavalcante
  • Tarcísio Laerte Gontijo
  • Thiago Magela Rodrigues Dias
  • Telemed J E Health.2020 Jul;doi: 10.1089/tmj.2020.0077.Epub 2020-07-14.

レスベラトロールは、デヒドロアスコルビン酸輸送および/またはHaCaT細胞におけるその細胞内還元を介して、細胞内のアスコルビン酸の濃縮を増強する

Resveratrol potentiates intracellular ascorbic acid enrichment through dehydroascorbic acid transport and/or its intracellular reduction in HaCaT cells.
  • Yasukazu Saitoh
  • Taiki Umezaki
  • Nene Yonekura
  • Atsushi Nakawa
  • Mol. Cell. Biochem..2020 Apr;467(1-2):57-64. 10.1007/s11010-020-03700-2. doi: 10.1007/s11010-020-03700-2.Epub 2020-02-21.

MGMTプロモーターのメチル化状態は、IDH野生型グリオブラストーマにおける組織学的特徴または放射線学的特徴とは関連していない

MGMT Promoter Methylation Status Is Not Related to Histological or Radiological Features in IDH Wild-type Glioblastomas.
  • Vilde Elisabeth Mikkelsen
  • Hong Yan Dai
  • Anne Line Stensjøen
  • Erik Magnus Berntsen
  • Øyvind Salvesen
  • Ole Solheim
  • Sverre Helge Torp
  • J. Neuropathol. Exp. Neurol..2020 Aug;79(8):855-862. 5874024. doi: 10.1093/jnen/nlaa060.

アモルファスヒドロゲルからの結晶化によるNi-Al層状二重水酸化物ナノ粒子からなる結晶性透明エアロゲルの合成

Synthesis of Crystalline and Transparent Aerogel composed of Ni-Al Layered Double Hydroxide Nanoparticles through Crystallization from Amorphous Hydrogel.
  • Masanori Takemoto
  • Yasuaki Tokudome
  • Daisuke Noguchi
  • Ryota Ueoka
  • Kazuyoshi Kanamori
  • Kenji Okada
  • Hidenobu Murata
  • Atsushi Nakahira
  • Masahide Takahashi
  • Langmuir.2020 Jul;doi: 10.1021/acs.langmuir.0c01292.Epub 2020-07-20.

X-Linked Charcot-Marie-Tooth Diseaseの一過性再発性中枢神経系臨床症状で、エピソード間の潜伏期間が非常に長い。長時間の日光曝露は誘発因子か？

Transient, Recurrent Central Nervous System Clinical Manifestations of X-Linked Charcot-Marie-Tooth Disease Presenting with Very Long Latency Periods between Episodes: Is Prolonged Sun Exposure a Provoking Factor?
  • Andria Tziakouri
  • Konstantinos Natsiopoulos
  • Kleopas A Kleopa
  • Costas Michaelides
  • Case Rep Neurol Med.2020;2020:9753139. doi: 10.1155/2020/9753139.Epub 2020-06-27.

HIV-1陽性者における抗レトロウイルス療法開始96週後の血中テロメア長とCD4+ CD8+ T細胞サブセットの変化との相関

Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1-positive individuals.
  • Mathieu Chalouni
  • Javier Rodriguez-Centeno
  • Assia Samri
  • Julian Blanco
  • Natalia Stella-Ascariz
  • Cedrick Wallet
  • Hernando Knobel
  • David Zucman
  • Belen Alejos Ferreras
  • Brigitte Autran
  • Rodolphe Thiebaut
  • François Raffi
  • Jose Ramon Arribas
  • PLoS ONE.2020;15(4):e0230772. PONE-D-19-29458. doi: 10.1371/journal.pone.0230772.Epub 2020-04-08.

伝統的な鋸歯状腺腫のモデルを開発するためのヒト大腸由来オルガノイドの染色体工学

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma.
  • Kenta Kawasaki
  • Masayuki Fujii
  • Shinya Sugimoto
  • Keiko Ishikawa
  • Mami Matano
  • Yuki Ohta
  • Kohta Toshimitsu
  • Sirirat Takahashi
  • Naoki Hosoe
  • Shigeki Sekine
  • Takanori Kanai
  • Toshiro Sato
  • Gastroenterology.2020 02;158(3):638-651.e8. S0016-5085(19)41446-7. doi: 10.1053/j.gastro.2019.10.009.Epub 2019-10-14.

マルチコンパートメント脱の管理のためのロボット支援骨盤底手術の長期的な解剖学的および機能的結果。プロスペクティブ研究

Long-term Anatomical and Functional Results of Robot-Assisted Pelvic Floor Surgery for the Management of Multicompartment Prolapse: A Prospective Study.
  • Femke van Zanten
  • Emma M van der Schans
  • Esther C J Consten
  • Paul M Verheijen
  • Egbert Lenters
  • Ivo A M J Broeders
  • Steven E Schraffordt Koops
  • Dis. Colon Rectum.2020 Jun;doi: 10.1097/DCR.0000000000001696.Epub 2020-06-24.

ヒトp21活性化キナーゼ5（PAK5）の発現と関連する癌における潜在的なメカニズム。分子がん治療のための基礎と臨床の展望

Human p21-activated kinase 5 (PAK5) expression and potential mechanisms in relevant cancers: Basic and clinical perspectives for molecular cancer therapeutics.
  • Yu-Kun Li
  • Juan Zou
  • Dong-Mei Ye
  • Ying Zeng
  • Chang-Ye Chen
  • Gui-Fang Luo
  • Xi Zeng
  • Life Sci..2020 Jan;241:117113. S0024-3205(19)31040-9. doi: 10.1016/j.lfs.2019.117113.Epub 2019-12-02.

進行性頭頸部扁平上皮がんにおけるTGF-βおよびPD-L1を標的とした二機能性融合タンパク質であるBintrafusp alfa：第I相コホートからの結果

Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort.
  • Byoung Chul Cho
  • Amaury Daste
  • Alain Ravaud
  • Sébastien Salas
  • Nicolas Isambert
  • Edward McClay
  • Ahmad Awada
  • Christian Borel
  • Laureen S Ojalvo
  • Christoph Helwig
  • P Alexander Rolfe
  • James L Gulley
  • Nicolas Penel
  • J Immunother Cancer.2020 Jul;8(2). e000664. doi: 10.1136/jitc-2020-000664.

チリの食品表示と広告法の実施前の食品と環境チリのコホート（FECHIC）の就学前の子供たちによる非栄養性甘味料の消費

Consumption of non-nutritive sweeteners by pre-schoolers of the food and environment Chilean cohort (FECHIC) before the implementation of the Chilean food labelling and advertising law.
  • Carolina Venegas Hargous
  • Marcela Reyes
  • Lindsey Smith Taillie
  • Carmen Gloria González
  • Camila Corvalán
  • Nutr J.2020 Jul;19(1):69. 10.1186/s12937-020-00583-3. doi: 10.1186/s12937-020-00583-3.Epub 2020-07-10.

心房細動および急性冠症候群で内科的治療を受けた患者、経皮的冠動脈インターベンションを受けた患者、または選択的経皮的冠動脈インターベンションを受けた患者における抗血栓療法。AUGUSTUS試験からの洞察

Antithrombotic Therapy in Patients With Atrial Fibrillation and Acute Coronary Syndrome Treated Medically or With Percutaneous Coronary Intervention or Undergoing Elective Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial.
  • Stephan Windecker
  • Renato D Lopes
  • Tyler Massaro
  • Charlotte Jones-Burton
  • Christopher B Granger
  • Ronald Aronson
  • Gretchen Heizer
  • Shaun G Goodman
  • Harald Darius
  • W Schuyler Jones
  • Michael Aschermann
  • David Brieger
  • Fernando Cura
  • Thomas Engstrøm
  • Viliam Fridrich
  • Sigrun Halvorsen
  • Kurt Huber
  • Hyun-Jae Kang
  • Jose L Leiva-Pons
  • Basil S Lewis
  • German Malaga
  • Nicolas Meneveau
  • Bela Merkely
  • Davor Milicic
  • João Morais
  • Tatjana S Potpara
  • Dimitar Raev
  • Manel Sabaté
  • Suzanne de Waha-Thiele
  • Robert C Welsh
  • Denis Xavier
  • Roxana Mehran
  • John H Alexander
  • Circulation.2019 12;140(23):1921-1932. doi: 10.1161/CIRCULATIONAHA.119.043308.Epub 2019-09-26.

高リン酸化タウが老化したタウ遺伝子導入マウスの海馬ニューロンの形態と興奮性に及ぼす影響

Consequences of hyperphosphorylated tau on the morphology and excitability of hippocampal neurons in aged tau transgenic mice.
  • Lennart Müller-Thomsen
  • Diba Borgmann
  • Kerstin Morcinek
  • Sophia Schröder
  • Brigitte Dengler
  • Natasha Moser
  • Felix Neumaier
  • Toni Schneider
  • Hannsjörg Schröder
  • Stefan Huggenberger
  • Neurobiol. Aging.2020 Sep;93:109-123. S0197-4580(20)30077-4. doi: 10.1016/j.neurobiolaging.2020.03.007.Epub 2020-03-16.

還元グラフェン酸化物とヒドロキシアパタイトナノワイヤーをベースにした柔軟な塩分拒否型光熱紙を開発し、太陽エネルギーを利用した高効率の蒸気発生と安定した海水淡水化を実現しました

Flexible Salt-Rejecting Photothermal Paper Based on Reduced Graphene Oxide and Hydroxyapatite Nanowires for High-Efficiency Solar Energy-Driven Vapor Generation and Stable Desalination.
  • Zhi-Chao Xiong
  • Ying-Jie Zhu
  • Dong-Dong Qin
  • Ri-Long Yang
  • ACS Appl Mater Interfaces.2020 Jul;doi: 10.1021/acsami.0c05986.Epub 2020-07-10.

製薬会社が開発した放射性医薬品を用いた医薬品の開発には、放射性廃棄物の発生を抑制するために、放射性廃棄物の発生を抑制するために、放射性廃棄物の発生を抑制することが重要である

Use of ESI-MS for semi-quantitative estimation of inactive precursor in no-carrier-added I- meta-Iodobenzylguanidine radiopharmaceutical preparation.
  • Anupam Mathur
  • Soumen Das
  • Navin Sakhare
  • S S Sachdev
  • J Pharm Biomed Anal.2019 Feb;165:261-267. S0731-7085(18)32018-1. doi: 10.1016/j.jpba.2018.12.016.Epub 2018-12-11.

ヒトヘルペスウイルス6B四量体糖タンパク質複合体と細胞受容体であるヒトCD134との相互作用の構造的基盤

Structural basis for the interaction of human herpesvirus 6B tetrameric glycoprotein complex with the cellular receptor, human CD134.
  • Mitsuhiro Nishimura
  • Bernadette Dian Novita
  • Takayuki Kato
  • Lidya Handayani Tjan
  • Bochao Wang
  • Aika Wakata
  • Anna Lystia Poetranto
  • Akiko Kawabata
  • Huamin Tang
  • Taiki Aoshi
  • Yasuko Mori
  • PLoS Pathog..2020 Jul;16(7):e1008648. PPATHOGENS-D-20-00217. doi: 10.1371/journal.ppat.1008648.Epub 2020-07-17.

超音波駆動バイオミメティックナノシステムは、ソノダイナミック療法、CO療法、インドールアミン2,3-ジオキシゲナーゼ阻害により、腫瘍の成長と転移を抑制する

Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition.
  • Da Zhang
  • Ziguo Lin
  • Youshi Zheng
  • Jibin Song
  • Juan Li
  • Yongyi Zeng
  • Xiaolong Liu
  • ACS Nano.2020 Jul;doi: 10.1021/acsnano.0c03833.Epub 2020-07-16.

インドネシア東部中央ティモール南部のマラリア流行地域におけるグルコース 6-リン酸デヒドロゲナーゼ変異体の有病率

Prevalence of Glucose 6-Phosphate Dehydrogenase Variants in Malaria-Endemic Areas of South Central Timor, Eastern Indonesia.
  • Novi Sulistyaningrum
  • Dona Arlinda
  • Jontari Hutagalung
  • Sunarno Sunarno
  • Intan Sari Oktoberia
  • Sarwo Handayani
  • Riyanti Ekowatiningsih
  • Endah Ariyanti Yusnita
  • Budi Prasetyorini
  • Aulia Rizki
  • Emiliana Tjitra
  • Kesara Na-Bangchang
  • Wanna Chaijaroenkul
  • Am. J. Trop. Med. Hyg..2020 Jun;doi: 10.4269/ajtmh.19-0780.Epub 2020-06-29.

D2ファミリー受容体アゴニストであるブロモクリプチンは、ニコチンではなく、NMDA受容体アンタゴニストによって誘発されたマウスの橈骨腕迷路における作業記憶障害を逆転させる

The D2-family receptor agonist bromocriptine but, not nicotine, reverses NMDA receptor antagonist-induced working memory deficits in the radial arm maze in mice.
  • David A MacQueen
  • Jared W Young
  • Neurobiol Learn Mem.2020 02;168:107159. S1074-7427(20)30003-4. doi: 10.1016/j.nlm.2020.107159.Epub 2020-01-03.

グローバルなB型肝炎ウイルス遺伝子型を持つB型肝炎ワクチンに対するモノクローナル抗体の免疫反応性パターン

Immunoreactivity pattern of monoclonal antibodies against Hepatitis B vaccine with global Hepatitis B Virus genotypes.
  • Forough Golsaz-Shirazi
  • Sahar Asadi-Asadabad
  • Hamzeh Sarvnaz
  • Mohammad Mehdi Amiri
  • Mohammad Hojjat-Farsangi
  • Michael Chudy
  • Mahmood Jeddi-Tehrani
  • Fazel Shokri
  • Clin. Chim. Acta.2020 Jul;S0009-8981(20)30350-8. doi: 10.1016/j.cca.2020.07.026.Epub 2020-07-14.

Streptococcus pyogenes型株の完全なゲノム配列は、PacBio-soloとIllumina-Oxfordナノポアハイブリッドアセンブリの間で100％一致していることが明らかになった

Complete genome sequences of Streptococcus pyogenes type strain reveal 100%-match between PacBio-solo and Illumina-Oxford Nanopore hybrid assemblies.
  • Francisco Salvà-Serra
  • Daniel Jaén-Luchoro
  • Hedvig E Jakobsson
  • Lucia Gonzales-Siles
  • Roger Karlsson
  • Antonio Busquets
  • Margarita Gomila
  • Antoni Bennasar-Figueras
  • Julie E Russell
  • Mohammed Abbas Fazal
  • Sarah Alexander
  • Edward R B Moore
  • Sci Rep.2020 Jul;10(1):11656. 10.1038/s41598-020-68249-y. doi: 10.1038/s41598-020-68249-y.Epub 2020-07-15.

グランザイムBはE-カドヘリンとFLG切断を介してオキサゾロン誘発性皮膚炎症のバリア機能障害に寄与している

Granzyme B Contributes to Barrier Dysfunction in Oxazolone-Induced Skin Inflammation through E-Cadherin and FLG Cleavage.
  • Christopher T Turner
  • Matthew R Zeglinski
  • Katlyn C Richardson
  • Stephanie Santacruz
  • Sho Hiroyasu
  • Christine Wang
  • Hongyan Zhao
  • Yue Shen
  • Roma Sehmi
  • Hermenio Lima
  • Gail M Gauvreau
  • David J Granville
  • J. Invest. Dermatol..2020 Jun;S0022-202X(20)31660-2. doi: 10.1016/j.jid.2020.05.095.Epub 2020-06-03.

イソプレニルシステインカルボキシルメチルトランスフェラーゼは、変異型KRASがTAZタンパク質レベルとがん細胞の自己複製に及ぼす影響に必要であることが明らかになった

Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal.
  • Tin Fan Chai
  • Kanjoormana Aryan Manu
  • Patrick J Casey
  • Mei Wang
  • Oncogene.2020 Jun;10.1038/s41388-020-1364-7. doi: 10.1038/s41388-020-1364-7.Epub 2020-06-19.

選択的なBCL-X PROTAC分解剤が安全で強力な抗腫瘍活性を達成しました

A selective BCL-X PROTAC degrader achieves safe and potent antitumor activity.
  • Sajid Khan
  • Xuan Zhang
  • Dongwen Lv
  • Qi Zhang
  • Yonghan He
  • Peiyi Zhang
  • Xingui Liu
  • Dinesh Thummuri
  • Yaxia Yuan
  • Janet S Wiegand
  • Jing Pei
  • Weizhou Zhang
  • Abhisheak Sharma
  • Christopher R McCurdy
  • Vinitha M Kuruvilla
  • Natalia Baran
  • Adolfo A Ferrando
  • Yong-Mi Kim
  • Anna Rogojina
  • Peter J Houghton
  • Guangcun Huang
  • Robert Hromas
  • Marina Konopleva
  • Guangrong Zheng
  • Daohong Zhou
  • Nat. Med..2019 12;25(12):1938-1947. 10.1038/s41591-019-0668-z. doi: 10.1038/s41591-019-0668-z.Epub 2019-12-02.

インターロイキン18と細胞外マトリックスメタロプロテアーゼインデューサーのクロスレギュレーション：急性心筋梗塞における意味合い

Interleukin 18 and extracellular matrix metalloproteinase inducer cross-regulation: implications in acute myocardial infarction.
  • Shuang-Lun Xie
  • Yu-Yang Chen
  • Hai-Feng Zhang
  • Bing-Qing Deng
  • Xiao-Rong Shu
  • Zi-Zhuo Su
  • Yong-Qing Lin
  • Ru-Qiong Nie
  • Jing-Feng Wang
  • Transl Res.2015 Mar;165(3):387-95. S1931-5244(14)00307-7. doi: 10.1016/j.trsl.2014.09.001.Epub 2014-09-11.

イヌラエフロス由来の天然化合物であるネペチンは、マスト細胞におけるPLCγ1およびAktシグナル伝達経路を介した脱顆粒およびエイコサノイドの生成を抑制する

Nepetin, a natural compound from Inulae flos, suppresses degranulation and eicosanoid generation through PLCγ1 and Akt signaling pathways in mast cells.
  • Ning Ji
  • Sun-Gun Kim
  • Hyo-Hyun Park
  • Eujin Lee
  • Youn Ju Lee
  • Meihua Jin
  • Eunkyung Lee
  • Arch. Pharm. Res..2020 Feb;43(2):224-232. 10.1007/s12272-020-01212-7. doi: 10.1007/s12272-020-01212-7.Epub 2020-02-03.

高安動脈炎患者の大動脈内炎症性病変におけるマクロファージ亜集団およびT細胞の臨床的特徴と治療法との関連性

Associations between clinical features and therapy with macrophage subpopulations and T cells in inflammatory lesions in the aorta from patients with Takayasu arteritis.
  • João Paulo Dos Santos
  • Ricardo Artigiani Neto
  • Cristóvão L P Mangueira
  • Rénee Z Filippi
  • Paulo S Gutierrez
  • Johanna Westra
  • Elisabeth Brouwer
  • Alexandre W S de Souza
  • Clin. Exp. Immunol..2020 Jul;doi: 10.1111/cei.13489.Epub 2020-07-08.

ベルガモットンは、ラットにおけるP糖タンパク質媒介の流出に影響を与えることなく、CYP3A媒介の腸内第一通過代謝を評価するために使用することができます

Bergamottin can be used to assess CYP3A-mediated intestinal first-pass metabolism without affecting P-glycoprotein-mediated efflux in rats.
  • Kei Suzuki
  • Kazuhiro Taniyama
  • Takao Aoyama
  • Yoshiaki Watanabe
  • Xenobiotica.2020 Apr;50(4):401-407. doi: 10.1080/00498254.2019.1644389.Epub 2019-08-01.

ヒノキフラボンは、ミトコンドリアのROS/JNK/caspase経路を活性化し、NF-κB活性を阻害することにより、肝細胞癌のアポトーシスを誘導することが示唆されました

Hinokiflavone induces apoptosis via activating mitochondrial ROS/JNK/caspase pathway and inhibiting NF-κB activity in hepatocellular carcinoma.
  • Wan Mu
  • Xuefang Cheng
  • Xue Zhang
  • Ying Liu
  • Qianzhou Lv
  • Gaolin Liu
  • Jigang Zhang
  • Xiaoyu Li
  • J. Cell. Mol. Med..2020 Jun;doi: 10.1111/jcmm.15474.Epub 2020-06-09.

UV-CプロセスおよびUV-C/PDSプロセスによるドデシル硫酸ナトリウムの回収のためのフェナントレンの選択的除去。性能、メカニズム、土壌洗浄リサイクル

Selective removal of phenanthrene for the recovery of sodium dodecyl sulfate by UV-C and UV-C/PDS processes: Performance, mechanism and soil washing recycling.
  • Zenan Wang
  • Tiantai Sun
  • Tian Luo
  • Xiaolu Shi
  • Heng Lin
  • Hui Zhang
  • J. Hazard. Mater..2020 Jun;400:123141. S0304-3894(20)31130-4. doi: 10.1016/j.jhazmat.2020.123141.Epub 2020-06-11.

メタロプロテアーゼとシステインプロテアーゼRNA転写物の検出 自然に感染した犬の耳の端の皮膚で

Detection of Metalloproteases and Cysteine Proteases RNA Transcripts of in Ear Edge Skin of Naturally Infected Dogs.
  • Laura Barral Veloso
  • Flávia de Oliveira Cardoso
  • Karen Dos Santos Charret
  • Matheus Pereira de Sá Silva
  • Luzia Monteiro de Castro Côrtes
  • Kátia da Silva Calabrese
  • Franklin Souza da Silva
  • Joel Fontes de Sousa
  • Marília Fonseca Rocha
  • Carlos Roberto Alves
  • Biomed Res Int.2020;2020:2615787. doi: 10.1155/2020/2615787.Epub 2020-06-24.

合併性筋緊張性ジストロフィーを伴う甲状腺ホルモン抵抗性の家族における甲状腺ホルモン受容体β遺伝子（P453AおよびC36Y）の2つの変異

Two Mutations in Thyroid Hormone Receptor Beta Gene (P453A and C36Y) in a Family with Resistance to Thyroid Hormone with Comorbid Myotonic Dystrophy.
  • Kyoko Takeda
  • Ken-Ichi Nemoto
  • Yoshitaka Hayashi
  • Michiyo Yamamoto
  • Ryoichi Sakuta
  • Tetsuya Kimura
  • Hiroshi Noto
  • Thyroid.2019 04;29(4):607-608. doi: 10.1089/thy.2018.0307.Epub 2019-02-22.

2つの先駆的転写因子、Krüppel-Like Transcription Factor 4とGlucocorticoid Receptorがウシヘルペスウイルス1 ICP0初期プロモーターを協調的にトランスアクティブ化し、生産的な感染を刺激することを明らかにした

Two Pioneer Transcription Factors, Krüppel-Like Transcription Factor 4 and Glucocorticoid Receptor, Cooperatively Transactivate the Bovine Herpesvirus 1 ICP0 Early Promoter and Stimulate Productive Infection.
  • Fouad S El-Mayet
  • Laximan Sawant
  • Prasanth Thunuguntla
  • Jing Zhao
  • Clinton Jones
  • J. Virol..2020 01;94(4). e01670-19. doi: 10.1128/JVI.01670-19.Epub 2020-01-31.

COVID-19とアンドロロジー。フランス語圏のアンドロロジー学会（Société d'Andrologie de langue Française SALF）の勧告

COVID-19 and andrology: Recommendations of the French-speaking society of andrology (Société d'Andrologie de langue Française SALF).
  • S Hamdi
  • M Bendayan
  • E Huyghe
  • J-C Soufir
  • E Amar
  • R El Osta
  • I Plotton
  • C Delalande
  • J Perrin
  • C Leroy
  • A Bouker
  • H Pons
  • H Lejeune
  • G Robin
  • F Boitrelle
  • Basic Clin Androl.2020;30:10. 106. doi: 10.1186/s12610-020-00106-4.Epub 2020-07-13.

タンザニアのManyara地域とMorogoro地域の農耕牧畜コミュニティにおけるリフトバレー、デング熱、チクングニヤウイルスへの曝露の血清学的証拠。タンザニアでは近年デング熱が発生している

Serological evidence of exposure to Rift Valley, Dengue and Chikungunya Viruses among agropastoral communities in Manyara and Morogoro regions in Tanzania: A community survey.
  • Rule M Budodo
  • Pius G Horumpende
  • Sixbert I Mkumbaye
  • Blandina T Mmbaga
  • Richard S Mwakapuja
  • Jaffu O Chilongola
  • PLoS Negl Trop Dis.2020 Jul;14(7):e0008061. PNTD-D-20-00051. doi: 10.1371/journal.pntd.0008061.Epub 2020-07-20.

リンゴ（Malus domestica）の光捕集クロロフィルa/b結合遺伝子ファミリーのゲノムワイド解析と、干ばつや浸透圧ストレスに対する耐性を付与するMdLhcb4.3の機能的特徴付け

Genome-wide analysis of the light-harvesting chlorophyll a/b-binding gene family in apple (Malus domestica) and functional characterization of MdLhcb4.3, which confers tolerance to drought and osmotic stress.
  • Shuang Zhao
  • Hanbing Gao
  • Jiawei Luo
  • Haibo Wang
  • Qinglong Dong
  • Yanpeng Wang
  • Kaiyan Yang
  • Ke Mao
  • Fengwang Ma
  • Plant Physiol. Biochem..2020 Jun;154:517-529. S0981-9428(20)30302-8. doi: 10.1016/j.plaphy.2020.06.022.Epub 2020-06-30.

不妊・妊娠における抗精子抗体の役割と避妊・抗不妊ワクチンデザインの可能性.研究の進展と先駆的なビジョン

Role of Antisperm Antibodies in Infertility, Pregnancy, and Potential forContraceptive and Antifertility Vaccine Designs: Research Progress and Pioneering Vision.
  • Vickram A S
  • Kuldeep Dhama
  • Sandip Chakraborty
  • Hari Abdul Samad
  • Shyma K Latheef
  • Khan Sharun
  • Sandip Kumar Khurana
  • Archana K
  • Ruchi Tiwari
  • Prakash Bhatt
  • Vyshali K
  • Wanpen Chaicumpa
  • Vaccines (Basel).2019 Sep;7(3). E116. doi: 10.3390/vaccines7030116.Epub 2019-09-16.

ニコチン酸アデニンジヌクレオチドリン酸は、内皮コロニー形成細胞においてリソソームCa放出を媒介する二孔チャネルTPC1を活性化する

Nicotinic acid adenine dinucleotide phosphate activates two-pore channel TPC1 to mediate lysosomal Ca release in endothelial colony-forming cells.
  • Francesco Moccia
  • Estella Zuccolo
  • Francesca Di Nezza
  • Giorgia Pellavio
  • Pawan S Faris
  • Sharon Negri
  • Antonio De Luca
  • Umberto Laforenza
  • Luigi Ambrosone
  • Vittorio Rosti
  • Germano Guerra
  • J. Cell. Physiol..2020 Jun;doi: 10.1002/jcp.29896.Epub 2020-06-24.

肥大型心筋症は、この遺伝子に変異があると常染色体劣性型の肥大型心筋症を引き起こす

Mutations in cause an autosomal-recessive form of hypertrophic cardiomyopathy.
  • Joel Salazar-Mendiguchía
  • Juan Pablo Ochoa
  • Julian Palomino-Doza
  • Fernando Domínguez
  • Carles Díez-López
  • Mohammed Akhtar
  • Soraya Ramiro-León
  • María M Clemente
  • Antonia Pérez-Cejas
  • María Robledo
  • Iria Gómez-Díaz
  • María Luisa Peña-Peña
  • Vicente Climent
  • Francisco Salmerón-Martínez
  • Celestino Hernández
  • Pablo E García-Granja
  • M Victoria Mogollón
  • Ivonne Cárdenas-Reyes
  • Marcos Cicerchia
  • Diego García-Giustiniani
  • Arsonval Lamounier
  • Belén Gil-Fournier
  • Felícitas Díaz-Flores
  • Rafael Salguero
  • Luis Santomé
  • Petros Syrris
  • Montse Olivé
  • Pablo García-Pavía
  • Martín Ortiz-Genga
  • Perry M Elliott
  • Lorenzo Monserrat
  • Heart.2020 May;heartjnl-2020-316913. doi: 10.1136/heartjnl-2020-316913.Epub 2020-05-25.

個別化された視覚野の反復経頭蓋磁気刺激によるうつ病治療のためのタスク関連機能的磁気共鳴画像法に基づくニューロナビゲーション

Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex.
  • Zhijun Zhang
  • Hongxing Zhang
  • Chun-Ming Xie
  • Meng Zhang
  • Yachen Shi
  • Ruize Song
  • Xiang Lu
  • Haisan Zhang
  • Kun Li
  • Bi Wang
  • Yongfeng Yang
  • Xianrui Li
  • Jianli Zhu
  • Yang Zhao
  • Ti-Fei Yuan
  • Georg Northoff
  • Sci China Life Sci.2020 Jun;10.1007/s11427-020-1730-5. doi: 10.1007/s11427-020-1730-5.Epub 2020-06-10.

SRSF1-3は、スプライシングおよび体細胞超変異調節因子であり、クロマチン調節因子SATB2、UBN1およびヒストンバリアントH3.3を介してIgV遺伝子の転写を制御している

SRSF1-3, a splicing and somatic hypermutation regulator, controls transcription of IgV genes via chromatin regulators SATB2, UBN1 and histone variant H3.3.
  • Amit Kumar Singh
  • Anubhav Tamrakar
  • Ankit Jaiswal
  • Naoki Kanayama
  • Prashant Kodgire
  • Mol. Immunol..2020 03;119:69-82. S0161-5890(19)30754-0. doi: 10.1016/j.molimm.2020.01.005.Epub 2020-01-25.

腹腔鏡下垂直スリーブ胃切除術（LVSG）と腹腔鏡下ルーザンY胃バイパス（LRYGB）の5年間の体重減少の成績。無作為化対照試験のシステマティックレビューとメタアナリシス

Five-Year Weight Loss Outcomes in Laparoscopic Vertical Sleeve Gastrectomy (LVSG) Versus Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) Procedures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
  • Emma J Osland
  • Rossita M Yunus
  • Shahjahan Khan
  • Muhammed A Memon
  • Surg Laparosc Endosc Percutan Tech.2020 Jul;doi: 10.1097/SLE.0000000000000834.Epub 2020-07-10.

ラット新生児初代アストロサイト培養物において、電離放射線はSTAT3シグナル伝達経路を介して血管内皮増殖因子の発現を調節する

Ionizing radiation modulates vascular endothelial growth factor expression through STAT3 signaling pathway in rat neonatal primary astrocyte cultures.
  • Guijuan Zhou
  • Yan Xu
  • Bing He
  • Rundong Ma
  • Yilin Wang
  • Yunqian Chang
  • Yangzhi Xie
  • Lin Wu
  • Jianghua Huang
  • Zijian Xiao
  • Brain Behav.2020 Apr;10(4):e01529. doi: 10.1002/brb3.1529.Epub 2020-02-27.

間葉系幹細胞の卵巣内注入は、ウシの受胎能力喪失モデルにおいて、卵子の収量と体外胚の産生を改善する

Intraovarian injection of mesenchymal stem cells improves oocyte yield and in vitro embryo production in a bovine model of fertility loss.
  • Patricia F Malard
  • Mauricio A S Peixer
  • Joao G Grazia
  • Hilana Dos Santos Sena Brunel
  • Luiz F Feres
  • Carla L Villarroel
  • Luiz G B Siqueira
  • Margot A N Dode
  • Robert Pogue
  • Joao Henrique M Viana
  • Juliana L Carvalho
  • Sci Rep.2020 May;10(1):8018. 10.1038/s41598-020-64810-x. doi: 10.1038/s41598-020-64810-x.Epub 2020-05-15.

CTから3Dプリントモデル、本気のゲーム、バーチャルリアリティまで。内側からの複雑な解剖学的空間の教育用3D可視化のためのフレームワーク - 翼口蓋骨窩

From CT to 3D Printed Models, Serious Gaming, and Virtual Reality: Framework for Educational 3D Visualization of Complex Anatomical Spaces From Within-the Pterygopalatine Fossa.
  • Ramin Javan
  • Aditya Rao
  • Bryan S Jeun
  • Aalap Herur-Raman
  • Neha Singh
  • Parisa Heidari
  • J Digit Imaging.2020 Jun;33(3):776-791. 10.1007/s10278-019-00315-y. doi: 10.1007/s10278-019-00315-y.

女性の下部尿路症状を有する女性における流量曲線の形状とビデオ尿力学的所見の比較：流量曲線の形状は女性の膀胱流出閉塞やデトラスターの活動低下を予測できるか？

A comparison of flow rate curve shape and video-urodynamic findings in women with lower urinary tract symptoms: can flow rate curve shape predict female bladder outflow obstruction or detrusor underactivity?
  • Huriye Kocadag
  • Bogdan Toia
  • Richard Axell
  • Habiba Yasmin
  • Mahreen H Pakzad
  • Rizwan Hamid
  • Tamsin J Greenwell
  • Jeremy L Ockrim
  • World J Urol.2020 Jul;10.1007/s00345-020-03343-4. doi: 10.1007/s00345-020-03343-4.Epub 2020-07-11.

クレマスチンはP38シグナル伝達経路を介してミクログリア由来のIL-1βを減少させることで、低酸素虚血性脳損傷ラットにおける骨髄化低下を改善します

Clemastine improves hypomyelination in rats with hypoxic-ischemic brain injury by reducing microglia-derived IL-1β via P38 signaling pathway.
  • Di Xie
  • Xiaoli Ge
  • Yanli Ma
  • Jialong Tang
  • Yang Wang
  • Yajie Zhu
  • Chengjin Gao
  • Shuming Pan
  • J Neuroinflammation.2020 Feb;17(1):57. 10.1186/s12974-019-1662-6. doi: 10.1186/s12974-019-1662-6.Epub 2020-02-15.

COVID-19パンデミックの開始時における既存のうつ病を持つアメリカの高齢者の経験。多施設、混合方法による研究

Experiences of American Older Adults with Pre-existing Depression During the Beginnings of the COVID-19 Pandemic: A Multicity, Mixed-Methods Study.
  • Megan E Hamm
  • Patrick J Brown
  • Jordan F Karp
  • Emily Lenard
  • Flor Cameron
  • Alicia Dawdani
  • Helen Lavretsky
  • J Philip Miller
  • Benoit H Mulsant
  • Vy T Pham
  • Charles F Reynolds
  • Steven P Roose
  • Eric J Lenze
  • Am J Geriatr Psychiatry.2020 Jun;S1064-7481(20)30382-1. doi: 10.1016/j.jagp.2020.06.013.Epub 2020-06-20.

非動脈瘤性くも膜下出血の治療における10年間の経験。単施設研究における転帰パラメータのレトロスペクティブ解析

Ten Years' Experiences in the Treatment of Nonaneurysmal Subarachnoid Hemorrhage: A Retrospective Analysis of Outcome Parameters in a Single-Center Study.
  • Mohammed Alhoobi
  • Fatma Abu-Qadous
  • Mohsin Khan
  • Ahmed Shaaban
  • Nissar Shaikh
  • Firas Hammadi
  • Raed Abu-Jarir
  • Walid Albanna
  • Ghaya Alrumaihi
  • Sirajelddin Belkhair
  • Arun R Babu
  • Ali Ayyad
  • Asian J Neurosurg.2020 Apr-Jun;15(2):315-321. AJNS-15-315. doi: 10.4103/ajns.AJNS_315_19.Epub 2020-04-07.

()-5-(2'-フルオロフェニル)-,-ジメチル-1,2,3,4-テトラヒドロナフタレン-2-アミンは、セロトニン受容体モジュレーターであり、フラジールX症候群および自閉症スペクトラム障害のノックアウトマウスモデルにおいて、抗痙攣性、反社会性、抗不安性に類似した特性を有する

()-5-(2'-Fluorophenyl)-,-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine, a Serotonin Receptor Modulator, Possesses Anticonvulsant, Prosocial, and Anxiolytic-like Properties in an Knockout Mouse Model of Fragile X Syndrome and Autism Spectrum Disorder.
  • Jessica L Armstrong
  • Austen B Casey
  • Tanishka S Saraf
  • Munmun Mukherjee
  • Raymond G Booth
  • Clinton E Canal
  • ACS Pharmacol Transl Sci.2020 Jun;3(3):509-523. doi: 10.1021/acsptsci.9b00101.Epub 2020-02-21.

アゾレス諸島の家畜放牧土壌におけるESBL産生大腸菌の発生：環境・健康汚染の問題か？

Occurrence of ESBL-producing Escherichia coli in soils subjected to livestock grazing in Azores archipelago: an environment-health pollution issue?
  • Vanessa Silva
  • Fernando Peixoto
  • Carolina Parelho
  • Patrícia Garcia
  • Armindo Rodrigues
  • Adriana Silva
  • Isabel Carvalho
  • José Eduardo Pereira
  • Gilberto Igrejas
  • Patrícia Alexandra Curado Quintas Dinis Poeta
  • Int. Microbiol..2020 Jun;10.1007/s10123-020-00134-0. doi: 10.1007/s10123-020-00134-0.Epub 2020-06-08.

血液学的悪性腫瘍の免疫学的展望

Immunogenomic Landscape of Hematological Malignancies.
  • Olli Dufva
  • Petri Pölönen
  • Oscar Brück
  • Mikko A I Keränen
  • Jay Klievink
  • Juha Mehtonen
  • Jani Huuhtanen
  • Ashwini Kumar
  • Disha Malani
  • Sanna Siitonen
  • Matti Kankainen
  • Bishwa Ghimire
  • Jenni Lahtela
  • Pirkko Mattila
  • Markus Vähä-Koskela
  • Krister Wennerberg
  • Kirsi Granberg
  • Suvi-Katri Leivonen
  • Leo Meriranta
  • Caroline Heckman
  • Sirpa Leppä
  • Matti Nykter
  • Olli Lohi
  • Merja Heinäniemi
  • Satu Mustjoki
  • Cancer Cell.2020 Jun;S1535-6108(20)30275-0. doi: 10.1016/j.ccell.2020.06.002.Epub 2020-06-24.

トランスジーンをコードするアデノ随伴ウイルスベクターのための定量的な力価アッセイ

A Quantitative Potency Assay for Adeno-Associated Virus Vectors Encoding for the Transgene.
  • Sem J Aronson
  • Robert S Bakker
  • Sascha Moenis
  • Remco van Dijk
  • Giulia Bortolussi
  • Fanny Collaud
  • Xiaoxia Shi
  • Suzanne Duijst
  • Lysbeth Ten Bloemendaal
  • Giuseppe Ronzitti
  • Andrés F Muro
  • Federico Mingozzi
  • Ulrich Beuers
  • Piter J Bosma
  • Mol Ther Methods Clin Dev.2020 Sep;18:250-258. S2329-0501(20)30124-8. doi: 10.1016/j.omtm.2020.06.002.Epub 2020-06-03.

コロナウイルス疾患入院患者の急性合併症と死亡率 2019年：システマティックレビューとメタアナリシス

Acute complications and mortality in hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis.
  • Nicola Potere
  • Emanuele Valeriani
  • Matteo Candeloro
  • Marco Tana
  • Ettore Porreca
  • Antonio Abbate
  • Silvia Spoto
  • Anne W S Rutjes
  • Marcello Di Nisio
  • Crit Care.2020 Jul;24(1):389. 10.1186/s13054-020-03022-1. doi: 10.1186/s13054-020-03022-1.Epub 2020-07-02.

慢性B型肝炎の相同プライムブースト免疫療法のための改変アルファウイルス-ベシキュロウイルスハイブリッドワクチンベクター

Modified Alphavirus-Vesiculovirus Hybrid Vaccine Vectors for Homologous Prime-Boost Immunotherapy of Chronic Hepatitis B.
  • Carolina Chiale
  • Timur O Yarovinsky
  • Stephen W Mason
  • Bhaskara R Madina
  • Manisha Menon
  • Marie M Krady
  • Safiehkhatoon Moshkani
  • Anasuya Chattopadhyay Pal
  • Bijan Almassian
  • John K Rose
  • Michael D Robek
  • Valerian Nakaar
  • Vaccines (Basel).2020 Jun;8(2). E279. doi: 10.3390/vaccines8020279.Epub 2020-06-05.

アセチルコリンエステラーゼ、ブチルコリンエステラーゼ、α-グリコシダーゼを含む代謝酵素の抗がん性と阻害効果の分子ドッキング研究による決定

Determination of anticancer properties and inhibitory effects of some metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, alpha-glycosidase of some compounds with molecular docking study.
  • Fikret Türkan
  • Parham Taslimi
  • Sakar Mübarak Abdalrazaq
  • Abdülmelik Aras
  • Yavuz Erden
  • Hasan Ufuk Celebioglu
  • Burak Tuzun
  • Mehmet Salih Ağırtaş
  • İlhami Gülçin
  • J. Biomol. Struct. Dyn..2020 Jun;:1-10. doi: 10.1080/07391102.2020.1768901.Epub 2020-06-04.

グリコシル化Ia型（CDG-Ia）の先天性障害を有するルーマニア人キャリアカップルにおける単発性疾患の着床前遺伝子検査（PGT-M）に関連した体外受精（IVF）。症例報告

In Vitro Fertilisation (IVF) Associated with Preimplantation Genetic Testing for Monogenic Diseases (PGT-M) in a Romanian Carrier Couple for Congenital Disorder of Glycosylation Type Ia (CDG-Ia): A Case Report.
  • Bogdan Doroftei
  • Loredana Nemtanu
  • Ovidiu-Dumitru Ilie
  • Gabriela Simionescu
  • Iuliu Ivanov
  • Emil Anton
  • Maria Puiu
  • Radu Maftei
  • Genes (Basel).2020 Jun;11(6). E697. doi: 10.3390/genes11060697.Epub 2020-06-25.

マトリックスメタロプロテアーゼ 3（MMP3）一塩基多型と腱鞘炎との関連：ハイレベルアスリートを対象としたケースコントロール研究

Association of the matrix metalloproteinase 3 (MMP3) single nucleotide polymorphisms with tendinopathies: case-control study in high-level athletes.
  • Nina Briški
  • Goran Vrgoč
  • Damir Knjaz
  • Saša Janković
  • Alan Ivković
  • Marko Pećina
  • Gordan Lauc
  • Int Orthop.2020 Jun;10.1007/s00264-020-04684-w. doi: 10.1007/s00264-020-04684-w.Epub 2020-06-30.

古代シルクロードに沿った初期の牧畜経済。アレイ渓谷、キルギスタンからの生体分子の証拠

Early pastoral economies along the Ancient Silk Road: Biomolecular evidence from the Alay Valley, Kyrgyzstan.
  • William Taylor
  • Svetlana Shnaider
  • Aida Abdykanova
  • Antoine Fages
  • Frido Welker
  • Franziska Irmer
  • Andaine Seguin-Orlando
  • Naveed Khan
  • Katerina Douka
  • Ksenia Kolobova
  • Ludovic Orlando
  • Andrei Krivoshapkin
  • Nicole Boivin
  • PLoS ONE.2018;13(10):e0205646. PONE-D-18-20515. doi: 10.1371/journal.pone.0205646.Epub 2018-10-31.

腸球菌フェカリスに対するメチレンブルー、クロリン-e6及びクルクミン媒介光力学療法に及ぼす光強度及び照射モードの影響

Influence of light intensity and irradiation mode on Methylene blue, Chlorin-e6 and Curcumin-Mediated Photodynamic Therapy against Enterococcus faecalis.
  • Laís Simões Sampaio
  • Sarah Raquel de Annunzio
  • Laura Marise de Freitas
  • Lívia Oliveira Dantas
  • Leonardo de Boni
  • Maria Carolina Donatoni
  • Kleber Thiago de Oliveira
  • Carla Raquel Fontana
  • Photodiagnosis Photodyn Ther.2020 Jul;:101925. S1572-1000(20)30279-9. doi: 10.1016/j.pdpdt.2020.101925.Epub 2020-07-17.

antagomiR-494の静脈内投与は、脳卒中実験において、HDAC2を介した多発性MMPの抑制を増加させることにより、脳への浸潤性好中球を減少させる

Intravenous antagomiR-494 lessens brain-infiltrating neutrophils by increasing HDAC2-mediated repression of multiple MMPs in experimental stroke.
  • Fangfang Li
  • Haiping Zhao
  • Guangwen Li
  • Sijia Zhang
  • Rongliang Wang
  • Zhen Tao
  • Yangmin Zheng
  • Ziping Han
  • Ping Liu
  • Qingfeng Ma
  • Yumin Luo
  • FASEB J..2020 May;34(5):6934-6949. doi: 10.1096/fj.201903127R.Epub 2020-04-02.

高線量率大腸内膜ブラキセラピーにおけるイッテルビウム-169、セレン-75およびイリジウム-192放射性同位元素の線量学的考察

Dosimetric Considerations for Ytterbium-169, Selenium-75, and Iridium-192 Radioisotopes in High-Dose-Rate Endorectal Brachytherapy.
  • Tristan Shoemaker
  • Té Vuong
  • Harry Glickman
  • Samar Kaifi
  • Gabriel Famulari
  • Shirin A Enger
  • Int. J. Radiat. Oncol. Biol. Phys..2019 11;105(4):875-883. S0360-3016(19)33449-2. doi: 10.1016/j.ijrobp.2019.07.003.Epub 2019-07-19.

多嚢胞性腎疾患に伴う網膜血管障害における可溶性エポキシドヒドロラーゼ阻害の保護効果

Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease.
  • Jihong Lin
  • Jiong Hu
  • Andrea Schlotterer
  • Jing Wang
  • Matthias Kolibabka
  • Khader Awwad
  • Nadine Dietrich
  • Kristin Breitschopf
  • Paulus Wohlfart
  • Aimo Kannt
  • Katrin Lorenz
  • Yuxi Feng
  • Rüdiger Popp
  • Sigrid Hoffmann
  • Ingrid Fleming
  • Hans Peter Hammes
  • Theranostics.2020;10(17):7857-7871. thnov10p7857. doi: 10.7150/thno.43154.Epub 2020-06-22.

ウシ精密切断肝切片におけるチトクローム P450 1A およびフラビンモノオキシゲナーゼアイソザイムの発現に対するフェンベンダゾールおよびトリクラベンダゾールの効果

Effects of fenbendazole and triclabendazole on the expression of cytochrome P450 1A and flavin-monooxygenase isozymes in bovine precision-cut liver slices.
  • L Maté
  • M Giantin
  • P Viviani
  • M Ballent
  • R Tolosi
  • A Lifschitz
  • C Lanusse
  • M Dacasto
  • G Virkel
  • Vet. J..2019 Mar;245:61-69. S1090-0233(18)30304-6. doi: 10.1016/j.tvjl.2019.01.001.Epub 2019-01-15.

予防投薬中の高リスク者において，システインは従来のホモシステインよりも冠動脈疾患の予測因子として優れている．

Cysteine is a better predictor of coronary artery disease than conventional homocysteine in high-risk subjects under preventive medication.
  • Ana Lima
  • Rita Ferin
  • António Fontes
  • Emília Santos
  • Dinis Martins
  • José Baptista
  • Maria L Pavão
  • Nutr Metab Cardiovasc Dis.2020 Jul;30(8):1281-1288. S0939-4753(20)30131-9. doi: 10.1016/j.numecd.2020.04.010.Epub 2020-04-20.

ラットモデルにおけるインスリン抵抗性と2型糖尿病の症状に対するゴーヤとプロピオン酸クロム複合体の効果

Effects of Bitter Melon and a Chromium Propionate Complex on Symptoms of Insulin Resistance and Type 2 Diabetes in Rat Models.
  • Pandora E White
  • Ewelina Król
  • Artur Szwengiel
  • Małgorzata Tubacka
  • Dawid Szczepankiewicz
  • Halina Staniek
  • John B Vincent
  • Zbigniew Krejpcio
  • Biol Trace Elem Res.2020 Jun;10.1007/s12011-020-02202-y. doi: 10.1007/s12011-020-02202-y.Epub 2020-06-02.

尿路病原性大腸菌分離株におけるqnr遺伝子を有するIncNプラスミドのin vitroおよびin vivoでの持続性について検討した

In vitro and in vivo persistence of IncN plasmids carrying qnr genes in uropathogenic Escherichia coli isolates.
  • Wilson Dias Segura
  • Haissa Pereira Ramos
  • Renata Ester de Faria Blanc Amorim
  • Ághata Cardoso da Silva Ribeiro
  • Edimar Cristiano Pereira
  • Rodrigo Cayô
  • Ana Cristina Gales
  • Antônio J Piantino Ferreira
  • Luciene Andrade da Rocha Minarini
  • J Glob Antimicrob Resist.2020 Jul;S2213-7165(20)30182-X. doi: 10.1016/j.jgar.2020.07.006.Epub 2020-07-17.

ｔｅｒｔ-ブチル３-シアノ-３-シクロプロピル-２-オキソピロリジン-４-カルボキシレートの効率的な合成。高機能化された2-ピロリジノンの合成により、新規な大環状Tyk2阻害剤へのアクセスが可能になった

Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors.
  • Yusuke Sasaki
  • Hidekazu Tokuhara
  • Yusuke Ohba
  • Atsutoshi Okabe
  • Masaharu Nakayama
  • Hideyuki Nakagawa
  • Robert Skene
  • Isaac Hoffman
  • Hua Zou
  • Masato Yoshida
  • Bioorg. Med. Chem. Lett..2020 Mar;30(5):126963. S0960-894X(20)30016-0. doi: 10.1016/j.bmcl.2020.126963.Epub 2020-01-13.

マクロメタスターゼ切除後に無病変であるIII/IV期メラノーマ患者のアジュバント治療としてのmRNAエレクトロポレーション自己単球由来樹状細胞（TriMixDC-MEL）に関する無作為化対照第II相臨床試験

A randomized controlled phase II clinical trial on mRNA electroporated autologous monocyte-derived dendritic cells (TriMixDC-MEL) as adjuvant treatment for stage III/IV melanoma patients who are disease-free following the resection of macrometastases.
  • Yanina Jansen
  • Vibeke Kruse
  • Jurgen Corthals
  • Kelly Schats
  • Pieter-Jan van Dam
  • Teofila Seremet
  • Carlo Heirman
  • Lieve Brochez
  • Mark Kockx
  • Kris Thielemans
  • Bart Neyns
  • Cancer Immunol. Immunother..2020 Jun;10.1007/s00262-020-02618-4. doi: 10.1007/s00262-020-02618-4.Epub 2020-06-26.

ジアルジア・デュオデナリスにおけるTRBD亜鉛フィンガー相互作用タンパク質の同定とテロメラーゼの制御機構の解明

Identification of a TRBD zinc finger-interacting protein in Giardia duodenalis and its regulation of telomerase.
  • Jing-Tong Zheng
  • Nan Zhang
  • Yan-Hui Yu
  • Peng-Tao Gong
  • Xian-He Li
  • Na Wu
  • Can Wang
  • Xiao-Cen Wang
  • Xin Li
  • Jian-Hua Li
  • Xi-Chen Zhang
  • Parasit Vectors.2019 Nov;12(1):568. 10.1186/s13071-019-3821-0. doi: 10.1186/s13071-019-3821-0.Epub 2019-11-29.

線虫の有害金属ストレス応答を制御するメディエーターサブユニットMDT-15/MED15と核内受容体HIZR-1/HNF4が協調している

Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans.
  • Naomi Shomer
  • Alexandre Zacharie Kadhim
  • Jennifer Margaret Grants
  • Xuanjin Cheng
  • Deema Alhusari
  • Forum Bhanshali
  • Amy Fong-Yuk Poon
  • Michelle Ying Ya Lee
  • Anik Muhuri
  • Jung In Park
  • James Shih
  • Dongyeop Lee
  • Seung-Jae V Lee
  • Francis Christopher Lynn
  • Stefan Taubert
  • PLoS Genet..2019 12;15(12):e1008508. PGENETICS-D-19-00492. doi: 10.1371/journal.pgen.1008508.Epub 2019-12-09.

UPLC-MS/MSによるロペラミド及びその主要代謝物であるN-脱メチル化ロペラミドのラットにおける薬物動態に及ぼすアクシチニブの影響の検討

Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS.
  • Qian-Meng Lin
  • Ni-Hong Pang
  • Ying-Hui Li
  • Huan-le Huang
  • Xiao-Dan Zhang
  • Guo-Xin Hu
  • Zeng-Shou Wang
  • Chem. Biol. Interact..2019 Sep;310:108744. S0009-2797(19)30152-8. doi: 10.1016/j.cbi.2019.108744.Epub 2019-07-09.

皮膚神経線維腫の組織学的診断および分類における観察者間のばらつきと精度を評価する

Assessing interobserver variability and accuracy in the histological diagnosis and classification of cutaneous neurofibromass.
  • Nicolas Ortonne
  • Steven L Carroll
  • Fausto J Rodriguez
  • Douglas C Miller
  • Rosalynn M Nazarian
  • Jaishri O Blakeley
  • Zachary B Madaj
  • Sharad K Verma
  • Anat Stemmer-Rachamimov
  • Neurooncol Adv.2020 Jul;2(Suppl 1):i117-i123. vdz050. doi: 10.1093/noajnl/vdz050.Epub 2019-12-05.

ゴムの木の内生菌株ITBB B5-1の野生株と変異株の遺伝子解析と免疫電子顕微鏡は、プロジゴシンの貯蔵と分泌におけるマクロベシクルの重要な役割を明らかにした

Genetic Analysis and Immunoelectron Microscopy of Wild and Mutant Strains of the Rubber Tree Endophytic Bacterium Strain ITBB B5-1 Reveal Key Roles of a Macrovesicle in Storage and Secretion of Prodigiosin.
  • Deguan Tan
  • Lili Fu
  • Xuepiao Sun
  • Long Xu
  • Jiaming Zhang
  • J. Agric. Food Chem..2020 May;68(20):5606-5615. doi: 10.1021/acs.jafc.0c00078.Epub 2020-04-10.

健康なヒト被験者を対象としたオランザピンとサミドルファンの併用投与の薬物動態に対するリファンピンの効果を評価するための第I相オープンラベル試験

A Phase I Open-Label Study to Evaluate the Effects of Rifampin on the Pharmacokinetics of Olanzapine and Samidorphan Administered in Combination in Healthy Human Subjects.
  • Lei Sun
  • David McDonnell
  • Miao Yu
  • Vipul Kumar
  • Lisa von Moltke
  • Clin Drug Investig.2019 May;39(5):477-484. 10.1007/s40261-019-00775-8. doi: 10.1007/s40261-019-00775-8.

COVID-19が確認された患者の1症例シリーズにおける急性腎障害（コロナウイルス疾患2019）．アンジオテンシン変換酵素2とレニン-アンジオテンシン系遮断薬の役割

Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade.
  • Avantika Chenna
  • Venu Madhav Konala
  • Subhasish Bose
  • Sasmit Roy
  • Bhaskar Reddy Madhira
  • Vijay Gayam
  • Srikanth Naramala
  • Sreedhar Adapa
  • Case Rep Nephrol.2020;2020:8811931. doi: 10.1155/2020/8811931.Epub 2020-06-29.

エベロリムス溶出性冠動脈ステント植え込み術を受けている患者における短期二重抗血小板療法後のクロピドグレル単剤療法 vs. アスピリン単剤療法

Clopidogrel Monotherapy vs. Aspirin Monotherapy Following Short-Term Dual Antiplatelet Therapy in Patients Receiving Everolimus-Eluting Coronary Stent Implantation.
  • Masahiro Natsuaki
  • Takeshi Morimoto
  • Hirotoshi Watanabe
  • Mitsuru Abe
  • Kazuya Kawai
  • Koichi Nakao
  • Kenji Ando
  • Kengo Tanabe
  • Yuji Ikari
  • Keiichi Igarashi Hanaoka
  • Yoshihiro Morino
  • Ken Kozuma
  • Kazushige Kadota
  • Takeshi Kimura
  • Circ. J..2020 Jul;doi: 10.1253/circj.CJ-20-0298.Epub 2020-07-18.

ラマダン（THYRAM）のレボチロキシン摂取に最適な時期。バスラの体験談

Best Time for Levothyroxine Intake in Ramadan (THYRAM): Basrah Experience.
  • Ibrahim Abbood Zaboon
  • Haider Ayad Alidrisi
  • Ibrahim Hani Hussein
  • Majid Alabbood
  • Nassar Taha Yaseen Alibrahim
  • Ammar Mohammed Saeed Almomin
  • Dheyaa Kadhim Al-Waeli
  • Ali Hussein Ali Alhamza
  • Adel Gassab Mohammed
  • Hussein Ali Nwayyir
  • Ahmed Jaafer Hindi Al-Ali
  • Abbas Ali Mansour
  • Int J Endocrinol Metab.2020 Apr;18(2):e94325. doi: 10.5812/ijem.94325.Epub 2020-04-06.

E2糖タンパク質ドメインI上のP108とT109は、古典的な豚熱ウイルスのウサギへの適応には重要であるが、豚での病原性には重要ではない

P108 and T109 on the E2 glycoprotein Domain I are critical for the adaptation of classical swine fever virus to rabbits but not the virulence in pigs.
  • Libao Xie
  • Yuying Han
  • Yuteng Ma
  • Mengqi Yuan
  • Weike Li
  • Lian-Feng Li
  • Miao Li
  • Yuan Sun
  • Yuzi Luo
  • Su Li
  • Shouping Hu
  • Yongfeng Li
  • Hua-Ji Qiu
  • J. Virol..2020 Jun;JVI.01104-20. doi: 10.1128/JVI.01104-20.Epub 2020-06-24.

α-1抗トリプシン欠損多能性幹細胞の高度に表現型化されたオープンアクセスリポジトリ

A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells.
  • Joseph E Kaserman
  • Killian Hurley
  • Mark Dodge
  • Carlos Villacorta-Martin
  • Marall Vedaie
  • Jyh-Chang Jean
  • Derek C Liberti
  • Marianne F James
  • Michelle I Higgins
  • Nora J Lee
  • George R Washko
  • Raul San Jose Estepar
  • Jeffrey Teckman
  • Darrell N Kotton
  • Andrew A Wilson
  • Stem Cell Reports.2020 Jul;15(1):242-255. S2213-6711(20)30227-7. doi: 10.1016/j.stemcr.2020.06.006.Epub 2020-07-02.

Ecdysis triggering hormoneがアカザリガニCherax quadricarinatusの脱皮行動を調節していることを明らかにし、甲殻類全体で脱皮調節機能が保存されていることを示唆した

Ecdysis triggering hormone modulates molt behaviour in the redclaw crayfish Cherax quadricarinatus, providing a mechanistic evidence for conserved function in molt regulation across Pancrustacea.
  • Tran Minh Nhut
  • Donald L Mykles
  • Abigail Elizur
  • Tomer Ventura
  • Gen. Comp. Endocrinol..2020 Jul;:113556. S0016-6480(20)30309-9. doi: 10.1016/j.ygcen.2020.113556.Epub 2020-07-17.

シトクロームP450 3Aの誘導はP-糖タンパク質の誘導を予測する；第1回：上昇用量リファンピンを用いた誘導関係の確立

Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin.
  • Justin D Lutz
  • Brian J Kirby
  • Lu Wang
  • Qinghua Song
  • John Ling
  • Benedetta Massetto
  • Angela Worth
  • Brian P Kearney
  • Anita Mathias
  • Clin. Pharmacol. Ther..2018 12;104(6):1182-1190. doi: 10.1002/cpt.1073.Epub 2018-04-19.

Pseudomonas sp. LFM046の代謝におけるポリヒドロキシアルカノエート生成のための補酵素特異性と6-ホスホグルコン酸デヒドロゲナーゼの存在との関連性

The relevance of enzyme specificity for coenzymes and the presence of 6-phosphogluconate dehydrogenase for polyhydroxyalkanoates production in the metabolism of Pseudomonas sp. LFM046.
  • Juliana Cardinali-Rezende
  • Alex Di Genova
  • Rafael A T P S Nahat
  • Alexander Steinbüchel
  • Marie-France Sagot
  • Rafael S Costa
  • Henrique C Oliveira
  • Marilda K Taciro
  • Luiziana F Silva
  • José Gregório C Gomez
  • Int. J. Biol. Macromol..2020 Jul;163:240-250. S0141-8130(20)33680-1. doi: 10.1016/j.ijbiomac.2020.06.226.Epub 2020-07-03.

高脂肪食誘発性肥満ラットにおけるロスバスタチンの肝内取り込み量減少を媒介する肝内Pxr-Oatp2経路の阻害を検討した

The inhibition of hepatic Pxr-Oatp2 pathway mediating decreased hepatic uptake of rosuvastatin in rats with high-fat diet-induced obesity.
  • Fan Zhang
  • Yingting Duan
  • Yuhui Wei
  • Jianping Zhang
  • Xiaohua Ma
  • Haiyan Tian
  • Xiaohui Wang
  • Abdulaziz Ahmed Abduladheem Saad
  • Boxia Li
  • Xinan Wu
  • Life Sci..2020 Jul;257:118079. S0024-3205(20)30830-4. doi: 10.1016/j.lfs.2020.118079.Epub 2020-07-12.

甲状腺機能と全死因死亡および心血管死亡のリスク：プロスペクティブ集団ベースのコホート研究

Thyroid function and risk of all-cause and cardiovascular mortality: a prospective population-based cohort study.
  • Dion Groothof
  • Jose L Flores-Guerrero
  • Ilja M Nolte
  • Hjalmar R Bouma
  • Eke G Gruppen
  • Arjola Bano
  • Adrian Post
  • Jenny E Kootstra-Ros
  • Eelko Hak
  • Jens H J Bos
  • Martin H de Borst
  • Reinold O B Gans
  • Thera P Links
  • Robin P F Dullaart
  • Stephan J L Bakker
  • Endocrine.2020 Jul;10.1007/s12020-020-02397-z. doi: 10.1007/s12020-020-02397-z.Epub 2020-07-06.

副腎皮質刺激ホルモンと成長ホルモン産生性二重下垂体腺腫の共存症状と腫瘍の局在化困難性：1 症例報告

[Coexisting Symptomatic Adrenocorticotropic Hormone- and Growth Hormone-producing Double Pituitary Adenomas with Difficulty in Tumor Localization:A Case Report].
  • Yuhei Ito
  • Shinya Jinguji
  • Yusuke Sato
  • Taku Sato
  • Yuta Murakami
  • Masazumi Fujii
  • Jun Sakuma
  • Mariko Iwasaki
  • Akihiro Kudo
  • Michio Shimabukuro
  • Yuichiro Kiko
  • Masayasu Okada
  • Kiyoshi Saito
  • No Shinkei Geka.2020 Mar;48(3):253-260. 1436204171. doi: 10.11477/mf.1436204171.

バイオサンプル中のペルオキシダーゼとアスコルビン酸の同時定量を、Fe(iii)/メチルチモールブルーカーボンドット模擬酵素をベースとした自動化システムで実現しました

Simultaneous quantification of peroxidase and ascorbic acid in biosamples with an automatic system based on a Fe(iii)/methylthymol blue-carbon dot simulative enzyme.
  • Yang Zhao
  • Qiao-Jing Li
  • Yong-Sheng Li
  • Xiu-Feng Gao
  • Analyst.2020 Jun;doi: 10.1039/d0an00291g.Epub 2020-06-23.

新規な7-ホルミルナフチリジルウレア誘導体の選択的FGFR4阻害剤としての可能性。新規7-ホルミルナフチリジルウレア誘導体の設計、合成、生物学的活性の研究

Novel 7-formyl-naphthyridyl-ureas derivatives as potential selective FGFR4 inhibitors: Design, synthesis, and biological activity studies.
  • Chang'an Sun
  • Lei Fang
  • Xiaobing Zhang
  • Peng Gao
  • Shaohua Gou
  • Bioorg. Med. Chem..2019 05;27(10):1932-1941. S0968-0896(19)30427-4. doi: 10.1016/j.bmc.2019.04.018.Epub 2019-04-10.

抗がん剤ダブラフェニブはヒト妊娠X受容体の強力な活性化剤である

The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor.
  • Nicolas Creusot
  • Matthieu Gassiot
  • Elina Alaterre
  • Barbara Chiavarina
  • Marina Grimaldi
  • Abdelhay Boulahtouf
  • Lucia Toporova
  • Sabine Gerbal-Chaloin
  • Martine Daujat-Chavanieu
  • Alice Matheux
  • Roger Rahmani
  • Céline Gongora
  • Alexandre Evrard
  • Philippe Pourquier
  • Patrick Balaguer
  • Cells.2020 Jul;9(7). E1641. doi: 10.3390/cells9071641.Epub 2020-07-08.

ヒト男性生殖細胞モデルであるTCam-2細胞におけるPUM1およびPUM2転写後制御因子のRNPネットワークの特性化

Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.
  • Maciej J Smialek
  • Erkut Ilaslan
  • Marcin P Sajek
  • Aleksandra Swiercz
  • Damian M Janecki
  • Kamila Kusz-Zamelczyk
  • Tomasz Wozniak
  • Maciej Kotecki
  • Luiza Handschuh
  • Marek Figlerowicz
  • Jadwiga Jaruzelska
  • Cells.2020 Apr;9(4). E984. doi: 10.3390/cells9040984.Epub 2020-04-16.

デュシェンヌ型筋ジストロフィーの初期段階における心臓ミトコンドリアにおけるCaの輸送とCa依存性の透過性転移

Transport of Ca and Ca-dependent permeability transition in heart mitochondria in the early stages of Duchenne muscular dystrophy.
  • Mikhail V Dubinin
  • Eugeny Yu Talanov
  • Kirill S Tenkov
  • Vlada S Starinets
  • Irina B Mikheeva
  • Konstantin N Belosludtsev
  • Biochim Biophys Acta Bioenerg.2020 Jun;1861(10):148250. S0005-2728(20)30100-6. doi: 10.1016/j.bbabio.2020.148250.Epub 2020-06-20.

ケニアにおける強化されたデータシステムを通じた新しい抗レトロウイルス治療レジメンへの移行のモニタリング

Monitoring the transition to new antiretroviral treatment regimens through an enhanced data system in Kenya.
  • Maria Lahuerta
  • Maureen Syowai
  • Shobha Vakil
  • Jacob Odhiambo
  • Mwenda Gitonga
  • Nandita Sugandhi
  • Stanslaus Odhiambo
  • Maureen Kimani
  • Joyce Wamicwe
  • James Batuka
  • Evans Imbuki
  • Kigen Bartilol
  • Elaine J Abrams
  • PLoS ONE.2020;15(4):e0232104. PONE-D-19-27109. doi: 10.1371/journal.pone.0232104.Epub 2020-04-23.

最初のクラスのNHE-1阻害薬としてのリメポリド。製薬企業は、このような研究を行うためには、研究開発のために必要な情報を収集する必要があります

Rimeporide as a first- in-class NHE-1 inhibitor: Results of a phase Ib trial in young patients with Duchenne Muscular Dystrophy.
  • Stefano C Previtali
  • Teresa Gidaro
  • Jordi Díaz-Manera
  • Alberto Zambon
  • Stephanie Carnesecchi
  • Pascale Roux-Lombard
  • Pietro Spitali
  • Mirko Signorelli
  • Cristina Al-Khalili Szigyarto
  • Camilla Johansson
  • Julian Gray
  • Delphine Labolle
  • Florence Porte Thomé
  • Jacqueline Pitchforth
  • Joana Domingos
  • Francesco Muntoni
  • Pharmacol. Res..2020 Jun;159:104999. S1043-6618(20)31307-4. doi: 10.1016/j.phrs.2020.104999.Epub 2020-06-12.

ヒストンH3.3のリジン4は、胚性幹細胞の分化、制御領域でのヒストン濃縮、転写精度に必要とされています

Lysine 4 of histone H3.3 is required for embryonic stem cell differentiation, histone enrichment at regulatory regions and transcription accuracy.
  • Maja Gehre
  • Daria Bunina
  • Simone Sidoli
  • Marlena J Lübke
  • Nichole Diaz
  • Matteo Trovato
  • Benjamin A Garcia
  • Judith B Zaugg
  • Kyung-Min Noh
  • Nat. Genet..2020 03;52(3):273-282. 10.1038/s41588-020-0586-5. doi: 10.1038/s41588-020-0586-5.Epub 2020-03-05.

木材保存地における銅の植物抽出用タバコの銅抵抗性ソーマクロナール変異体1種とクローン2種の現地評価

Field evaluation of one Cu-resistant somaclonal variant and two clones of tobacco for copper phytoextraction at a wood preservation site.
  • Aliaksandr Kolbas
  • Rolf Herzig
  • Lilian Marchand
  • Jean-Paul Maalouf
  • Natallia Kolbas
  • Michel Mench
  • Environ Sci Pollut Res Int.2020 Aug;27(22):27831-27848. 10.1007/s11356-020-09151-y. doi: 10.1007/s11356-020-09151-y.Epub 2020-05-12.

2013年から2016年の間に米国食品医薬品局（FDA）が承認した薬剤との臨床的に関連する薬物動態に基づく薬物-薬物相互作用のリスク

Risk of Clinically Relevant Pharmacokinetic-Based Drug-Drug Interactions with Drugs Approved by the U.S. Food and Drug Administration Between 2013 and 2016.
  • Jingjing Yu
  • Zhu Zhou
  • Jessica Tay-Sontheimer
  • René H Levy
  • Isabelle Ragueneau-Majlessi
  • Drug Metab. Dispos..2018 Jun;46(6):835-845. dmd.117.078691. doi: 10.1124/dmd.117.078691.Epub 2018-03-23.

アゾール耐性カンジダ株に対して活性な大環状アミジノウレアであるBM1のin vitro特性評価、ADME解析、組織学的・毒性評価を行った

In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains.
  • Francesco Orofino
  • Giuseppina I Truglio
  • Diego Fiorucci
  • Ilaria D'Agostino
  • Matteo Borgini
  • Federica Poggialini
  • Claudio Zamperini
  • Elena Dreassi
  • Laura Maccari
  • Riccardo Torelli
  • Cecilia Martini
  • Micaela Bernabei
  • Jacques F Meis
  • Nitesh Kumar Khandelwal
  • Rajendra Prasad
  • Maurizio Sanguinetti
  • Francesca Bugli
  • Maurizio Botta
  • Int. J. Antimicrob. Agents.2020 Mar;55(3):105865. S0924-8579(19)30336-X. doi: 10.1016/j.ijantimicag.2019.105865.Epub 2019-12-20.

CDC14BとCDK1のUSP9Xに対するアンタゴニスティックな活性はWT1依存性の有糸分裂の転写と生存を制御する

Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival.
  • Michael Dietachmayr
  • Abirami Rathakrishnan
  • Oleksandra Karpiuk
  • Felix von Zweydorf
  • Thomas Engleitner
  • Vanesa Fernández-Sáiz
  • Petra Schenk
  • Marius Ueffing
  • Roland Rad
  • Martin Eilers
  • Christian Johannes Gloeckner
  • Katharina Clemm von Hohenberg
  • Florian Bassermann
  • Nat Commun.2020 03;11(1):1268. 10.1038/s41467-020-15059-5. doi: 10.1038/s41467-020-15059-5.Epub 2020-03-09.

フロリダ州ジャクソンビルのスーパーファンド灰サイトにおけるコミュニティベースの参加型調査。毒物学のトレーニングを実施して一般市民の知識を向上させた

Community-Based Participatory Research at Jacksonville Florida Superfund Ash Site: Toxicology Training to Improve the Knowledge of the Lay Community.
  • Alan Becker
  • Sandra Suther
  • Cynthia Harris
  • Grazyna Pawlowicz
  • Gale Tucker
  • Matthew Dutton
  • Fran Close
  • Aaron Hilliard
  • Richard Gragg
  • Fla Public Health Rev.2019 May;15(1-7):61-74.

COVID-19危機時の完全な人工呼吸サポートへの可能性のある橋渡しとしての流量制御弁を用いた差動換気。ベンチからベッドサイドへ

Differential Ventilation Using Flow Control Valves as a Potential Bridge to Full Ventilatory Support during the COVID-19 Crisis: From Bench to Bedside.
  • Matthew A Levin
  • Anjan Shah
  • Ronak Shah
  • Erica Kane
  • George Zhou
  • James B Eisenkraft
  • Martin D Chen
  • Daniel Katz
  • Chang Park
  • Cheuk Yin Lai
  • Garrett Burnett
  • Christopher Gidicsin
  • Jonathan Madek
  • Suzan Uysal
  • Roopa Kohli-Seth
  • Andrew B Leibowitz
  • Anesthesiology.2020 Jul;doi: 10.1097/ALN.0000000000003473.Epub 2020-07-02.

フッ化物の毒性：疫学研究、動物実験およびin vitro分析におけるヒト発達神経毒性の証拠の批判的評価

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses.
  • Sabine Guth
  • Stephanie Hüser
  • Angelika Roth
  • Gisela Degen
  • Patrick Diel
  • Karolina Edlund
  • Gerhard Eisenbrand
  • Karl-Heinz Engel
  • Bernd Epe
  • Tilman Grune
  • Volker Heinz
  • Thomas Henle
  • Hans-Ulrich Humpf
  • Henry Jäger
  • Hans-Georg Joost
  • Sabine E Kulling
  • Alfonso Lampen
  • Angela Mally
  • Rosemarie Marchan
  • Doris Marko
  • Eva Mühle
  • Michael A Nitsche
  • Elke Röhrdanz
  • Richard Stadler
  • Christoph van Thriel
  • Stefan Vieths
  • Rudi F Vogel
  • Edmund Wascher
  • Carsten Watzl
  • Ute Nöthlings
  • Jan G Hengstler
  • Arch. Toxicol..2020 05;94(5):1375-1415. 10.1007/s00204-020-02725-2. doi: 10.1007/s00204-020-02725-2.Epub 2020-05-08.

熱走査アッセイを用いた多タンパク質原核生物のオルガネラへのプローブにより、コアとシェルの異なる特性が明らかになった

Probe into a multi-protein prokaryotic organelle using thermal scanning assay reveals distinct properties of the core and the shell.
  • Naimat K Bari
  • Jagadish P Hazra
  • Gaurav Kumar
  • Simerpreet Kaur
  • Sharmistha Sinha
  • Biochim Biophys Acta Gen Subj.2020 Jul;1864(10):129680. S0304-4165(20)30192-6. doi: 10.1016/j.bbagen.2020.129680.Epub 2020-07-04.

右側転移性大腸直腸癌に対するFOLFOXIRIと二重レジメンの比較。その後の治療法と全生存率への影響に焦点を当てる

FOLFOXIRI Versus Doublet Regimens in Right-Sided Metastatic Colorectal Cancer: Focus on Subsequent Therapies and Impact on Overall Survival.
  • Alexandre A Jácome
  • Bryan Kee
  • David Fogelman
  • Arvind Dasari
  • Imad Shureiqi
  • Kanwal Raghav
  • Van Morris
  • Benny Johnson
  • Michael Overman
  • Robert Wolff
  • Scott Kopetz
  • Jane Rogers
  • Shahab U Ahmed
  • Amir Mehdizadeh
  • Nicole Rothschild
  • Cathy Eng
  • Clin Colorectal Cancer.2020 Jun;S1533-0028(20)30083-9. doi: 10.1016/j.clcc.2020.05.010.Epub 2020-06-05.

褐色マダニRhipicephalus sanguineus (s.l.)のサイアロトランスクリプトームとサイアロプロテオームの統合的解析。血液摂食時の遺伝子発現の解明

Integrated analysis of sialotranscriptome and sialoproteome of the brown dog tick Rhipicephalus sanguineus (s.l.): Insights into gene expression during blood feeding.
  • Lucas Tirloni
  • Stephen Lu
  • Eric Calvo
  • Gabriela Sabadin
  • Lucia Sanchez Di Maggio
  • Motoshi Suzuki
  • Glenn Nardone
  • Itabajara da Silva Vaz
  • José M C Ribeiro
  • J Proteomics.2020 Jul;:103899. S1874-3919(20)30267-0. doi: 10.1016/j.jprot.2020.103899.Epub 2020-07-13.

ニューヨーク市におけるCOVID-19を持つ重症児と青年の臨床症状と転帰

Clinical Manifestations and Outcomes of Critically Ill Children and Adolescents with COVID-19 in New York City.
  • Kim R Derespina
  • Shubhi Kaushik
  • Anna Plichta
  • Edward E Conway
  • Asher Bercow
  • Jaeun Choi
  • Ruth Eisenberg
  • Jennifer Gillen
  • Anita I Sen
  • Claire M Hennigan
  • Lillian M Zerihun
  • Sule Doymaz
  • Michael A Keenaghan
  • Stephanie Jarrin
  • Franscene Oulds
  • Manoj Gupta
  • Louisdon Pierre
  • Melissa Grageda
  • H Michael Ushay
  • Vinay M Nadkarni
  • Michael S D Agus
  • Shivanand S Medar
  • J. Pediatr..2020 Jul;S0022-3476(20)30888-X. doi: 10.1016/j.jpeds.2020.07.039.Epub 2020-07-15.

三重陰性乳癌における長鎖遺伝子間ノンコーディングRNA 299遺伝子のDNAメチル化：前向き研究からの結果

DNA methylation of the long intergenic noncoding RNA 299 gene in triple-negative breast cancer: results from a prospective study.
  • Mehdi Manoochehri
  • Michael Jones
  • Katarzyna Tomczyk
  • Olivia Fletcher
  • Minouk J Schoemaker
  • Anthony J Swerdlow
  • Nasim Borhani
  • Ute Hamann
  • Sci Rep.2020 Jul;10(1):11762. 10.1038/s41598-020-68506-0. doi: 10.1038/s41598-020-68506-0.Epub 2020-07-16.

レスベラトロールの治療は、脂質制御と高脂肪食を与えられたウサギのリポタンパク質関連ホスホリパーゼA2（Lp-PLA2）の阻害に関連付けられています

Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet.
  • Lei Xu
  • Renjie Wang
  • Hongyu Liu
  • Jiaoqi Wang
  • Jing Mang
  • Zhongxin Xu
  • Evid Based Complement Alternat Med.2020;2020:9641582. doi: 10.1155/2020/9641582.Epub 2020-05-20.

間葉系間葉系間質細胞におけるDNA損傷修復応答：細胞の老化・老化からアポトーシス・分化能まで

DNA damage repair response in mesenchymal stromal cells: from cellular senescence and aging to apoptosis and differentiation ability.
  • Behnaz Banimohamad-Shotorbani
  • Houman Kahroba
  • Hadi Sadeghzadeh
  • David M Wilson
  • Hamid Maadi
  • Nasser Samadi
  • Mohammad Saeid Hejazi
  • Hekmat Farajpour
  • Behzad Nemati Onari
  • Mohammad Reza Sadeghi
  • Ageing Res. Rev..2020 Jul;:101125. S1568-1637(20)30260-9. doi: 10.1016/j.arr.2020.101125.Epub 2020-07-16.

シャルコー・マリー・トゥース神経症における軸索輸送障害とGlyRS-HDAC6相互作用の関連性

Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy.
  • Zhongying Mo
  • Xiaobei Zhao
  • Huaqing Liu
  • Qinghua Hu
  • Xu-Qiao Chen
  • Jessica Pham
  • Na Wei
  • Ze Liu
  • Jiadong Zhou
  • Robert W Burgess
  • Samuel L Pfaff
  • C Thomas Caskey
  • Chengbiao Wu
  • Ge Bai
  • Xiang-Lei Yang
  • Nat Commun.2018 03;9(1):1007. 10.1038/s41467-018-03461-z. doi: 10.1038/s41467-018-03461-z.Epub 2018-03-08.

海洋生物侵入を評価するためのオンラインアンケートの利用。地中海沿岸3カ国でのレクリエーション漁業者と大西洋アブラガニCallinectes sapidus (Rathbun, 1986)を対象とした実証実験

Using online questionnaires to assess marine bio-invasions: A demonstration with recreational fishers and the Atlantic blue crab Callinectes sapidus (Rathbun, 1986) along three Mediterranean countries.
  • Jacopo Cerri
  • Stefania Chiesa
  • Luca Bolognini
  • Giorgio Mancinelli
  • Fabio Grati
  • Branko Dragičević
  • Jakov Dulčic
  • Ernesto Azzurro
  • Mar. Pollut. Bull..2020 Jul;156:111209. S0025-326X(20)30327-1. doi: 10.1016/j.marpolbul.2020.111209.Epub 2020-05-11.

ハイブリッドライ麦のバイオマス収量予測を改善するために、遺伝子型、ハイパースペクトル、表現型データを統合する

Integration of genotypic, hyperspectral, and phenotypic data to improve biomass yield prediction in hybrid rye.
  • Rodrigo José Galán
  • Angela-Maria Bernal-Vasquez
  • Christian Jebsen
  • Hans-Peter Piepho
  • Patrick Thorwarth
  • Philipp Steffan
  • Andres Gordillo
  • Thomas Miedaner
  • Theor. Appl. Genet..2020 Jul;10.1007/s00122-020-03651-8. doi: 10.1007/s00122-020-03651-8.Epub 2020-07-17.

大腿骨セグメント欠損に対するMasquelet手技の第II期における髄腔内爪と人工関節への線維性支柱移植の追加。手技のヒント

Adding a Fibular Strut Allograft to Intramedullary Nail and Cancellous Autograft During Stage II of the Masquelet Technique for Segmental Femur Defects: A Technique Tip.
  • Omar Ramos
  • Michael Mariorenzi
  • Joey P Johnson
  • Roman A Hayda
  • J Am Acad Orthop Surg Glob Res Rev.2020 Jul;4(7):e1900179. 01979360-202007000-00006. doi: 10.5435/JAAOSGlobal-D-19-00179.

インドネシアの土壌菌、Talaromyces pinophilusに由来するPlasmodium falciparum dihydroorotate dehydrogenaseに対して活性な微生物阻害剤 BioMCC-f.T.3979

Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979.
  • Amila Pramisandi
  • Kazuyuki Dobashi
  • Mihoko Mori
  • Kenichi Nonaka
  • Atsuko Matsumoto
  • Toshiyuki Tokiwa
  • Mayuka Higo
  • Kristiningrum
  • Eri Amalia
  • Arif Nurkanto
  • Daniel Ken Inaoka
  • Danang Waluyo
  • Kiyoshi Kita
  • Tomoyoshi Nozaki
  • Satoshi Ōmura
  • Kazuro Shiomi
  • J. Gen. Appl. Microbiol..2020 Jul;doi: 10.2323/jgam.2019.11.007.Epub 2020-07-14.

ヒトフィブロネクチンのエキストラドメインAとHPV16/18 E7ウイルス抗原との融合タンパク質からなるHPV16/18遺伝子型に対する二価ワクチンの開発

Bivalent therapeutic vaccine against HPV16/18 genotypes consisting of a fusion protein between the extra domain A from human fibronectin and HPV16/18 E7 viral antigens.
  • Laura Arribillaga
  • Iciar Echeverria
  • Viriginia Belsue
  • Timothy Gomez
  • Teresa Lozano
  • Noelia Casares
  • Lorea Villanueva
  • Sonia Domingos-Pereira
  • Pedro J Romero
  • Denise Nardelli-Haefliger
  • Sandra Hervás-Stubbs
  • Pablo Sarobe
  • María Josefa Rodriguez
  • José L Carrascosa
  • Thomas Zürcher
  • Juan José Lasarte
  • J Immunother Cancer.2020 06;8(1). e000704. doi: 10.1136/jitc-2020-000704.

放射線は、RAW 264.7細胞およびマウス骨髄由来マクロファージの細胞骨格および溶解酵素を制御することにより、破骨細胞形成を変化させる

Radiation alters osteoclastogenesis by regulating the cytoskeleton and lytic enzymes in RAW 264.7 cells and mouse bone marrow-derived macrophages.
  • Ling Tong
  • Yuyang Wang
  • Jianping Wang
  • Feilong He
  • Jianglong Zhai
  • Jiangtao Bai
  • Guoying Zhu
  • Int. J. Radiat. Biol..2020 Jul;:1-26. doi: 10.1080/09553002.2020.1798542.Epub 2020-07-20.

空間的に構造化された集団における感染症の発生規模は、局所的な伝播と長距離分散のトレードオフが駆動している

Trade-off between local transmission and long-range dispersal drives infectious disease outbreak size in spatially structured populations.
  • Elisa Benincà
  • Thomas Hagenaars
  • Gert Jan Boender
  • Jan van de Kassteele
  • Michiel van Boven
  • PLoS Comput. Biol..2020 Jul;16(7):e1008009. PCOMPBIOL-D-19-01465. doi: 10.1371/journal.pcbi.1008009.Epub 2020-07-06.

分数的要因設計と中央複合設計の組み合わせを用いた、魚類副産物からのうま味成分の超音波支援酵素抽出条件の最適化

Optimisation of ultrasound-assisted enzymatic extraction conditions of umami compounds from fish by-products using the combination of fractional factorial design and central composite design.
  • Fabrice Bruno Siewe
  • Tanaji G Kudre
  • Bhaskar Narayan
  • Food Chem.2020 Jul;334:127498. S0308-8146(20)31360-1. doi: 10.1016/j.foodchem.2020.127498.Epub 2020-07-10.

化学感覚細胞由来のアセチルコリンは気管粘膜クリアランスをウイルス性ホルミルペプチドに応答して駆動する

Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.
  • Alexander Perniss
  • Shuya Liu
  • Brett Boonen
  • Maryam Keshavarz
  • Anna-Lena Ruppert
  • Thomas Timm
  • Uwe Pfeil
  • Aichurek Soultanova
  • Soumya Kusumakshi
  • Lucas Delventhal
  • Öznur Aydin
  • Martina Pyrski
  • Klaus Deckmann
  • Torsten Hain
  • Nadine Schmidt
  • Christa Ewers
  • Andreas Günther
  • Günter Lochnit
  • Vladimir Chubanov
  • Thomas Gudermann
  • Johannes Oberwinkler
  • Jochen Klein
  • Katsuhiko Mikoshiba
  • Trese Leinders-Zufall
  • Stefan Offermanns
  • Burkhard Schütz
  • Ulrich Boehm
  • Frank Zufall
  • Bernd Bufe
  • Wolfgang Kummer
  • Immunity.2020 Apr;52(4):683-699.e11. S1074-7613(20)30118-7. doi: 10.1016/j.immuni.2020.03.005.

AMPK依存的にHDAC8をリン酸化することでPGM1の発現が促進され、グルコース飢餓下での肺癌細胞の生存が促進されることを明らかにした

AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation.
  • Yanping Li
  • Ronghui Liang
  • Mingming Sun
  • Zhen Li
  • Hao Sheng
  • Jiyan Wang
  • Pengjuan Xu
  • Shuangping Liu
  • Wancai Yang
  • Bin Lu
  • Shuai Zhang
  • Changliang Shan
  • Cancer Lett..2020 May;478:82-92. S0304-3835(20)30126-9. doi: 10.1016/j.canlet.2020.03.007.Epub 2020-03-20.

JEN1とADY2の欠失により、異種乳酸脱水素酵素を発現するサッカロミセス・セレビシエのキシロース培地での乳酸収量が減少することを明らかにした

Deletion of JEN1 and ADY2 reduces lactic acid yield from an engineered Saccharomyces cerevisiae, in xylose medium, expressing a heterologous lactate dehydrogenase.
  • Timothy L Turner
  • Stephan Lane
  • Lahiru N Jayakody
  • Guo-Chang Zhang
  • Heejin Kim
  • Whiyeon Cho
  • Yong-Su Jin
  • FEMS Yeast Res..2019 09;19(6). foz050. doi: 10.1093/femsyr/foz050.

遺伝情報を公表するのはいつで、誰の責任なのか？BRCA遺伝性がんリスクの開示に関する医療専門家の見解についての横断的質的研究

When to break the news and whose responsibility is it? A cross-sectional qualitative study of health professionals' views regarding disclosure of BRCA genetic cancer risk.
  • Alison Luk Young
  • Phyllis N Butow
  • Katherine M Tucker
  • Claire E Wakefield
  • Emma Healey
  • Rachel Williams
  • BMJ Open.2020 02;10(2):e033127. bmjopen-2019-033127. doi: 10.1136/bmjopen-2019-033127.Epub 2020-02-25.

重度の白内障はM1中大脳動脈閉塞性脳卒中の再灌流術成功後の不良な転帰と関連している

Severe Leukoaraiosis Is Associated with Poor Outcome after Successful Recanalization of M1 Middle Cerebral Artery Occlusion Strokes.
  • Johannes Sebastian Mutzenbach
  • Erasmia Müller-Thies-Broussalis
  • Monika Killer-Oberpfalzer
  • Christoph Johannes Griessenauer
  • Constantin Hecker
  • Luis Rafael Moscote-Salazar
  • Pia Paradaiser
  • Slaven Pikija
  • Cerebrovasc. Dis..2020 Jun;:1-9. 000508209. doi: 10.1159/000508209.Epub 2020-06-12.

コラーゲンの安定同位体分析によるサケ科魚類の移動生態タイプの鑑別。考古学的・生態学的応用

Differentiating salmonid migratory ecotypes through stable isotope analysis of collagen: Archaeological and ecological applications.
  • Eric Guiry
  • Thomas C A Royle
  • R G Matson
  • Hillary Ward
  • Tyler Weir
  • Nicholas Waber
  • Thomas J Brown
  • Brian P V Hunt
  • Michael H H Price
  • Bruce P Finney
  • Masahide Kaeriyama
  • Yuxue Qin
  • Dongya Y Yang
  • Paul Szpak
  • PLoS ONE.2020;15(4):e0232180. PONE-D-20-03408. doi: 10.1371/journal.pone.0232180.Epub 2020-04-28.

脳卒中後片麻痺患者の下肢筋電図活動に対する生理学的感受性の高い歩行運動の意義.低リソース環境におけるフィージビリティスタディ

Implications of Physiology-Sensitive Gait Exercise on the Lower Limb Electromyographic Activity of Hemiplegic Post-Stroke Patients: A Feasibility Study in Low Resource Settings.
  • Dhaval Solanki
  • Siddhant Kumar
  • B Shubha
  • Uttama Lahiri
  • IEEE J Transl Eng Health Med.2020;8:2100709. 2100709. doi: 10.1109/JTEHM.2020.3006181.Epub 2020-07-01.

成人期のスティル病と乳がんに対する放射線治療。この稀な学会の管理についての症例報告と文献レビュー

Adult Onset Still's Disease and Radiotherapy treatment for breast cancer: Case report about management of this rare association and literature review.
  • Fabio Marazzi
  • Valeria Masiello
  • Gianluca Franceschini
  • Silvia Bosello
  • Francesca Moschella
  • Daniela Smaniotto
  • Stefano Luzi
  • Antonino Mulé
  • Maria Antonietta Gambacorta
  • Elisa Gremese
  • Riccardo Masetti
  • Vincenzo Valentini
  • Rep Pract Oncol Radiother.2020 Jul-Aug;25(4):527-532. S1507-1367(20)30042-0. doi: 10.1016/j.rpor.2020.03.013.Epub 2020-05-22.

COVID-19患者のヘリコプター搬送に関するガイドライン作成のための意思決定支援ツールと提案

Decision support tool and suggestions for the development of guidelines for the helicopter transport of patients with COVID-19.
  • Per P Bredmose
  • Monica Diczbalis
  • Emma Butterfield
  • Karel Habig
  • Andrew Pearce
  • Svein Are Osbakk
  • Ville Voipio
  • Marcus Rudolph
  • Alistair Maddock
  • John O'Neill
  • Scand J Trauma Resusc Emerg Med.2020 May;28(1):43. 10.1186/s13049-020-00736-7. doi: 10.1186/s13049-020-00736-7.Epub 2020-05-25.

韓国でCOVID-19感染症の三次感染を引き起こした指標患者の症例：定量的RT-PCRでモニターしたCOVID-19感染肺炎の治療にロピナビル/リトナビルの適用を検討

Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR.
  • Jaegyun Lim
  • Seunghyun Jeon
  • Hyun Young Shin
  • Moon Jung Kim
  • Yu Min Seong
  • Wang Jun Lee
  • Kang Won Choe
  • Yu Min Kang
  • Baeckseung Lee
  • Sang Joon Park
  • J. Korean Med. Sci..2020 Feb;35(6):e79. 35.e79. doi: 10.3346/jkms.2020.35.e79.Epub 2020-02-17.

術後の急性疼痛管理のためのガバペンチノイドの周術期使用：システマティックレビューとメタアナリシス

Perioperative Use of Gabapentinoids for the Management of Postoperative Acute Pain: A Systematic Review and Meta-analysis.
  • Michael Verret
  • François Lauzier
  • Ryan Zarychanski
  • Caroline Perron
  • Xavier Savard
  • Anne-Marie Pinard
  • Guillaume Leblanc
  • Marie-Joëlle Cossi
  • Xavier Neveu
  • Alexis F Turgeon
  • Anesthesiology.2020 08;133(2):265-279. 00000542-202008000-00011. doi: 10.1097/ALN.0000000000003428.

乳がんの高齢女性における虚弱体質とホルモン療法補助療法のアドヒアランス。CALGBプロトコル369901

Frailty and adherence to adjuvant hormonal therapy in older women with breast cancer: CALGB protocol 369901.
  • Vanessa B Sheppard
  • Leigh Anne Faul
  • George Luta
  • Jonathan D Clapp
  • Rachel L Yung
  • Judy Huei-Yu Wang
  • Gretchen Kimmick
  • Claudine Isaacs
  • Michelle Tallarico
  • William T Barry
  • Brandelyn N Pitcher
  • Clifford Hudis
  • Eric P Winer
  • Harvey J Cohen
  • Hyman B Muss
  • Arti Hurria
  • Jeanne S Mandelblatt
  • J. Clin. Oncol..2014 Aug;32(22):2318-27. JCO.2013.51.7367. doi: 10.1200/JCO.2013.51.7367.Epub 2014-06-16.

ガーナ・クマシの第三次病院における産後女性の尊重的なマタニティケアの経験を測定するためのツールの開発

Developing a tool for measuring postpartum women's experiences of respectful maternity care at a tertiary hospital in Kumasi, Ghana.
  • Veronica Millicent Dzomeku
  • Adwoa Bemah Boamah Mensah
  • Kweku Emmanuel Nakua
  • Pascal Agbadi
  • Jody R Lori
  • Peter Donkor
  • Heliyon.2020 Jul;6(7):e04374. S2405-8440(20)31218-4. doi: 10.1016/j.heliyon.2020.e04374.Epub 2020-07-10.

界面活性剤によりヌクレアーゼへのDNAアクセス性が向上し、淋菌の表現型β-ラクタム系抗生物質感受性試験が加速された

Surfactant-enhanced DNA accessibility to nuclease accelerates phenotypic β-lactam antibiotic susceptibility testing of Neisseria gonorrhoeae.
  • Emily S Savela
  • Nathan G Schoepp
  • Matthew M Cooper
  • Justin C Rolando
  • Jeffrey D Klausner
  • Olusegun O Soge
  • Rustem F Ismagilov
  • PLoS Biol..2020 03;18(3):e3000651. PBIOLOGY-D-19-01871. doi: 10.1371/journal.pbio.3000651.Epub 2020-03-19.

Gluconacetobacter diazotrophicus (Gd6PGD)由来の新規な膜関連6-ホスホグルコン酸デヒドロゲナーゼの構造から、短鎖6PGDのサブファミリーが明らかになった

The structure of a novel membrane-associated 6-phosphogluconate dehydrogenase from Gluconacetobacter diazotrophicus (Gd6PGD) reveals a subfamily of short-chain 6PGDs.
  • Pedro D Sarmiento-Pavía
  • Annia Rodríguez-Hernández
  • Adela Rodríguez-Romero
  • Martha E Sosa-Torres
  • FEBS J..2020 Jul;doi: 10.1111/febs.15472.Epub 2020-07-04.

胃もたれ症の症状を持つ患者における大麻の使用。有病率、患者の特徴、および知覚された有益性

Marijuana Use in Patients with Symptoms of Gastroparesis: Prevalence, Patient Characteristics, and Perceived Benefit.
  • Henry P Parkman
  • Emily P Sharkey
  • Linda A Nguyen
  • Katherine P Yates
  • Thomas L Abell
  • William L Hasler
  • William Snape
  • John Clarke
  • Ron Schey
  • Kenneth L Koch
  • Braden Kuo
  • Richard W McCallum
  • Irene Sarosiek
  • Madhusudan Grover
  • Gianrico Farrugia
  • James Tonascia
  • Pankaj J Pasricha
  • Dig. Dis. Sci..2020 Aug;65(8):2311-2320. 10.1007/s10620-019-05963-2. doi: 10.1007/s10620-019-05963-2.Epub 2019-11-22.

アンドロゲンが媒介する性の偏りは、オスにおけるロイコトリエン生合成阻害剤の効率を損なう

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.
  • Simona Pace
  • Carlo Pergola
  • Friederike Dehm
  • Antonietta Rossi
  • Jana Gerstmeier
  • Fabiana Troisi
  • Helmut Pein
  • Anja M Schaible
  • Christina Weinigel
  • Silke Rummler
  • Hinnak Northoff
  • Stefan Laufer
  • Thorsten J Maier
  • Olof Rådmark
  • Bengt Samuelsson
  • Andreas Koeberle
  • Lidia Sautebin
  • Oliver Werz
  • J. Clin. Invest..2017 Aug;127(8):3167-3176. 92885. doi: 10.1172/JCI92885.Epub 2017-07-24.

CDX2導入によるヒトiPSC由来腸管上皮細胞単分子膜の作製

Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction.
  • Kazuo Takayama
  • Ryosuke Negoro
  • Tomoki Yamashita
  • Kanae Kawai
  • Moe Ichikawa
  • Takanori Mori
  • Noriyuki Nakatsu
  • Kazuo Harada
  • Sumito Ito
  • Hiroshi Yamada
  • Yoshiyuki Yamaura
  • Kazumasa Hirata
  • Seiichi Ishida
  • Hiroyuki Mizuguchi
  • Cell Mol Gastroenterol Hepatol.2019;8(3):513-526. S2352-345X(19)30082-7. doi: 10.1016/j.jcmgh.2019.06.004.Epub 2019-06-19.

エプスタイン-バーウイルスエピトープ-主要組織適合性複合体の相互作用と収束的な組み換えが、多様なT細胞受容体αおよびβレパートワイアの選択を促進することを明らかにした

Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor α and β Repertoires.
  • Anna Gil
  • Larisa Kamga
  • Ramakanth Chirravuri-Venkata
  • Nuray Aslan
  • Fransenio Clark
  • Dario Ghersi
  • Katherine Luzuriaga
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  • mBio.2020 03;11(2). e00250-20. doi: 10.1128/mBio.00250-20.Epub 2020-03-17.

リゾホスファチジン酸は好中球の細胞外トラップの迅速な形成を誘導して血栓の安定性を促進する。血栓症の新たなメカニズム

Lysophosphatidic acid promotes thrombus stability by inducing rapid formation of neutrophil extracellular traps: A new mechanism of thrombosis.
  • Tiewei Li
  • Rui Peng
  • Fang Wang
  • Lu Hua
  • Sheng Liu
  • Zhiyan Han
  • Jianqiu Pei
  • Shengqiang Pei
  • Zhenwen Zhao
  • Xin Jiang
  • Xi Chen
  • J. Thromb. Haemost..2020 Apr;doi: 10.1111/jth.14839.Epub 2020-04-15.

妊娠中のステロイド新生はHIV-1 Tatとモルヒネによって変化する。生理的アロプレグナノロンは、神経毒作用や精神運動作用に対して保護されます

Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects.
  • Jason J Paris
  • Philippe Liere
  • Sarah Kim
  • Fakhri Mahdi
  • Meagan E Buchanan
  • Sara R Nass
  • Alaa N Qrareya
  • Mohammed F Salahuddin
  • Antoine Pianos
  • Neïké Fernandez
  • Zia Shariat-Madar
  • Pamela E Knapp
  • Michael Schumacher
  • Kurt F Hauser
  • Neurobiol Stress.2020 May;12:100211. S2352-2895(20)30001-1. doi: 10.1016/j.ynstr.2020.100211.Epub 2020-01-29.

抗甲状腺癌剤バンデタニブを酸化するヒト酵素の同定とその酸化におけるチトクロームP450 3A4の高効率性の説明

Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.
  • Radek Indra
  • Petr Pompach
  • Václav Martínek
  • Paulína Takácsová
  • Katarína Vavrová
  • Zbyněk Heger
  • Vojtěch Adam
  • Tomáš Eckschlager
  • Kateřina Kopečková
  • Volker Manfred Arlt
  • Marie Stiborová
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インドの病院隣接水域におけるカルバペネム耐性腸内細菌のニューデリーメタロ-β-ラクタマーゼ1およびセファロスポリン耐性遺伝子の検出

Detection of New Delhi Metallo-β-lactamase 1 and Cephalosporin Resistance Genes Among Carbapenem-Resistant Enterobacteriaceae in Water Bodies Adjacent to Hospitals in India.
  • Sneha Girijan Kalasseril
  • Rahul Krishnan
  • Rejish Kumar Vattiringal
  • Robin Paul
  • Philip Mathew
  • Devika Pillai
  • Curr. Microbiol..2020 Jul;10.1007/s00284-020-02107-y. doi: 10.1007/s00284-020-02107-y.Epub 2020-07-08.

初期の母子相互作用における母親のトラウマと感情的な可用性：マーシー妊娠と感情的ウェルビーイング研究（MPEWS）コホートからの知見

Maternal trauma and emotional availability in early mother-infant interaction: findings from the Mercy Pregnancy and Emotional Well-being Study (MPEWS) cohort.
  • Kelli K MacMillan
  • Andrew J Lewis
  • Stuart J Watson
  • Brendan Jansen
  • Megan Galbally
  • Attach Hum Dev.2020 Jul;:1-23. doi: 10.1080/14616734.2020.1790116.Epub 2020-07-20.

関連肺炎患者が使用した電子タバコ、またはベイピング製品の特徴と法執行機関が押収した製品 - ミネソタ州、2018年と2019年

Characteristics of E-cigarette, or Vaping, Products Used by Patients with Associated Lung Injury and Products Seized by Law Enforcement - Minnesota, 2018 and 2019.
  • Joanne Taylor
  • Terra Wiens
  • Jason Peterson
  • Stefan Saravia
  • Mark Lunda
  • Kaila Hanson
  • Matt Wogen
  • Paige D'Heilly
  • Jamie Margetta
  • Maria Bye
  • Cory Cole
  • Erica Mumm
  • Lauren Schwerzler
  • Roon Makhtal
  • Richard Danila
  • Ruth Lynfield
  • Stacy Holzbauer
  • MMWR Morb. Mortal. Wkly. Rep..2019 Nov;68(47):1096-1100. doi: 10.15585/mmwr.mm6847e1.Epub 2019-11-29.

訂正します。アルツハイマー病における新規GLP-1アナログリラグルチドの効果を評価する：無作為化比較試験（ELAD試験）のための研究プロトコル

Correction to: Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study).
  • Grazia Daniela Femminella
  • Eleni Frangou
  • Sharon B Love
  • Gail Busza
  • Clive Holmes
  • Craig Ritchie
  • Robert Lawrence
  • Brady McFarlane
  • George Tadros
  • Basil H Ridha
  • Carol Bannister
  • Zuzana Walker
  • Hilary Archer
  • Elizabeth Coulthard
  • Ben R Underwood
  • Aparna Prasanna
  • Paul Koranteng
  • Salman Karim
  • Kehinde Junaid
  • Bernadette McGuinness
  • Ramin Nilforooshan
  • Ajay Macharouthu
  • Andrew Donaldson
  • Simon Thacker
  • Gregor Russell
  • Naghma Malik
  • Vandana Mate
  • Lucy Knight
  • Sajeev Kshemendran
  • John Harrison
  • Christian Hölscher
  • David J Brooks
  • Anthony Peter Passmore
  • Clive Ballard
  • Paul Edison
  • Trials.2020 Jul;21(1):660. 10.1186/s13063-020-04608-4. doi: 10.1186/s13063-020-04608-4.Epub 2020-07-19.

Δ-THCおよび関連するカンナビノイドは、カンナビノイドCB受容体の活性化を介してサブスタンスP-誘発ニューロキニンNK受容体を介した嘔吐を抑制する

Δ-THC and related cannabinoids suppress substance P- induced neurokinin NK-receptor-mediated vomiting via activation of cannabinoid CB receptor.
  • Nissar A Darmani
  • Louiza Belkacemi
  • Weixia Zhong
  • Eur. J. Pharmacol..2019 Dec;865:172806. S0014-2999(19)30758-7. doi: 10.1016/j.ejphar.2019.172806.Epub 2019-11-15.

都市下水のメタゲノミクス解析に基づく抗菌薬耐性のグローバルモニタリング

Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage.
  • Rene S Hendriksen
  • Patrick Munk
  • Patrick Njage
  • Bram van Bunnik
  • Luke McNally
  • Oksana Lukjancenko
  • Timo Röder
  • David Nieuwenhuijse
  • Susanne Karlsmose Pedersen
  • Jette Kjeldgaard
  • Rolf S Kaas
  • Philip Thomas Lanken Conradsen Clausen
  • Josef Korbinian Vogt
  • Pimlapas Leekitcharoenphon
  • Milou G M van de Schans
  • Tina Zuidema
  • Ana Maria de Roda Husman
  • Simon Rasmussen
  • Bent Petersen
  • Clara Amid
  • Guy Cochrane
  • Thomas Sicheritz-Ponten
  • Heike Schmitt
  • Jorge Raul Matheu Alvarez
  • Awa Aidara-Kane
  • Sünje J Pamp
  • Ole Lund
  • Tine Hald
  • Mark Woolhouse
  • Marion P Koopmans
  • Håkan Vigre
  • Thomas Nordahl Petersen
  • Frank M Aarestrup
  • Nat Commun.2019 03;10(1):1124. 10.1038/s41467-019-08853-3. doi: 10.1038/s41467-019-08853-3.Epub 2019-03-08.

成人の体脂肪と体組成に及ぼすキャノーラ油、ゴマ油、ゴマカノーラ油の効果：三重盲検、三方無作為化クロスオーバー臨床試験

The effect of canola, sesame and sesame-canola oils on body fat and composition in adults: a triple-blind, three-way randomised cross-over clinical trial.
  • Fatemeh Moghtaderi
  • Mojgan Amiri
  • Alireza Zimorovat
  • Hamidreza Raeisi-Dehkordi
  • Masoud Rahmanian
  • Mahdieh Hosseinzadeh
  • Hossein Fallahzadeh
  • Amin Salehi-Abargouei
  • Int J Food Sci Nutr.2020 Jul;:1-10. doi: 10.1080/09637486.2020.1786024.Epub 2020-07-20.

乳児性胆汁性胆汁症の難治性診断における血漿オキシステロールの貢献

The contribution of plasma oxysterols in the challenging diagnostic work-up of infantile cholestasis.
  • Andrea Pietrobattista
  • Silvio Veraldi
  • Manila Candusso
  • Maria Sole Basso
  • Daniela Liccardo
  • Claudia Della Corte
  • Antonella Mosca
  • Tommaso Alterio
  • Elisa Sacchetti
  • Giulio Catesini
  • Federica Deodato
  • Sara Boenzi
  • Carlo Dionisi-Vici
  • Clin. Chim. Acta.2020 Aug;507:181-186. S0009-8981(20)30182-0. doi: 10.1016/j.cca.2020.04.028.Epub 2020-04-27.

運動補正された3D全心臓水脂肪高分解能後期ガドリニウム増強心臓血管磁気共鳴イメージング

Motion-corrected 3D whole-heart water-fat high-resolution late gadolinium enhancement cardiovascular magnetic resonance imaging.
  • Camila Munoz
  • Aurelien Bustin
  • Radhouene Neji
  • Karl P Kunze
  • Christoph Forman
  • Michaela Schmidt
  • Reza Hajhosseiny
  • Pier-Giorgio Masci
  • Martin Zeilinger
  • Wolfgang Wuest
  • René M Botnar
  • Claudia Prieto
  • J Cardiovasc Magn Reson.2020 Jul;22(1):53. 10.1186/s12968-020-00649-5. doi: 10.1186/s12968-020-00649-5.Epub 2020-07-20.

大腿四頭筋腱の中央部と内側の各層は、ハムストリングスや腸脛骨バンドグラフトと同様の引張特性を提供します

Every layer of quadriceps tendon's central and medial portion offers similar tensile properties than Hamstrings or Ilio-Tibial Band Grafts.
  • Matthieu Chivot
  • Charles Pioger
  • Jérémy Cognault
  • Akash Sharma
  • Regis Pailhé
  • Etienne Cavaignac
  • Matthieu Ollivier
  • Christophe Jacquet
  • J Exp Orthop.2020 Jul;7(1):50. 10.1186/s40634-020-00261-7. doi: 10.1186/s40634-020-00261-7.Epub 2020-07-10.

CT上の小型金属インプラントの金属アーチファクト低減：どの画像再構成アルゴリズムがより優れた性能を発揮するか？

Metal artifact reduction for small metal implants on CT: Which image reconstruction algorithm performs better?
  • Aurélie Grandmougin
  • Omar Bakour
  • Nicolas Villani
  • Cedric Baumann
  • Hélène Rousseau
  • Pedro Augusto Gondim Teixeira
  • Alain Blum
  • Eur J Radiol.2020 Jun;127:108970. S0720-048X(20)30159-5. doi: 10.1016/j.ejrad.2020.108970.Epub 2020-03-19.

成人発症スティル病のアナキンラ（組換えヒトIL-1受容体拮抗薬）による治療：文献の系統的レビュー

The treatment of adult-onset Still's disease with anakinra, a recombinant human IL-1 receptor antagonist: a systematic review of literature.
  • Roberto Giacomelli
  • Jurgen Sota
  • Piero Ruscitti
  • Corrado Campochiaro
  • Serena Colafrancesco
  • Lorenzo Dagna
  • Daniela Iacono
  • Florenzo Iannone
  • Giuseppe Lopalco
  • Paolo Sfriso
  • Luca Cantarini
  • Clin. Exp. Rheumatol..2020 May;:. 15252. Epub 2020-05-12.

Aviax 5%（セムデュラマイシンナトリウム）の肥育用ニワトリに対する安全性と有効性についての科学的意見

Scientific Opinion on the safety and efficacy of Aviax 5% (semduramicin sodium) for chickens for fattening.
  • Guido Rychen
  • Gabriele Aquilina
  • Giovanna Azimonti
  • Vasileios Bampidis
  • Maria de Lourdes Bastos
  • Georges Bories
  • Andrew Chesson
  • Pier Sandro Cocconcelli
  • Gerhard Flachowsky
  • Boris Kolar
  • Maryline Kouba
  • Marta López-Alonso
  • Secundino López Puente
  • Alberto Mantovani
  • Baltasar Mayo
  • Fernando Ramos
  • Maria Saarela
  • Roberto Edoardo Villa
  • Robert John Wallace
  • Pieter Wester
  • Paul Brantom
  • Ingrid Halle
  • Patrick van Beelen
  • Orsolya Holczknecht
  • Maria Vittoria Vettori
  • Jürgen Gropp
  • EFSA J.2018 Jul;16(7):e05341. EFS25341. doi: 10.2903/j.efsa.2018.5341.Epub 2018-07-23.

FGFR4受容体のGly385(388)Arg多型が健康な食生活下で肝脂肪形成を制御していることを明らかにした

The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet.
  • Stefan Z Lutz
  • Anita M Hennige
  • Andreas Peter
  • Marketa Kovarova
  • Charisis Totsikas
  • Jürgen Machann
  • Stefan M Kröber
  • Bianca Sperl
  • Erwin Schleicher
  • Fritz Schick
  • Martin Heni
  • Axel Ullrich
  • Hans-Ulrich Häring
  • Norbert Stefan
  • J. Clin. Endocrinol. Metab..2019 06;104(6):2041-2053. 5239680. doi: 10.1210/jc.2018-01573.

大腿四頭筋腱の自家移植による前十字靭帯再建は、移植片破断率は低いが、ハムストリングス腱の自家移植と比較して患者報告の成績は類似している。875例の患者の比較

Anterior Cruciate Ligament Reconstructions With Quadriceps Tendon Autograft Result in Lower Graft Rupture Rates but Similar Patient-Reported Outcomes as Compared With Hamstring Tendon Autograft: A Comparison of 875 Patients.
  • Armin Runer
  • Robert Csapo
  • Caroline Hepperger
  • Mirco Herbort
  • Christian Hoser
  • Christian Fink
  • Am J Sports Med.2020 Jul;48(9):2195-2204. doi: 10.1177/0363546520931829.

カゼインホスホペプチド-非晶質リン酸カルシウムが、従来の生体活性流動性コンポジットと自己接着性コンポジットを用いた再接着歯片の破壊抵抗性に及ぼす影響

Effect of Casein Phosphopeptide-Amorphous Calcium Phosphate on Fracture Resistance of Reattached Tooth Fragments Using Conventional and Self-Adhesive Bioactive Flowable Composite.
  • Maryam Firouzmandi
  • Neda Afzali
  • Zahra Parsaie
  • Najmeh Mohammadi
  • Eur J Dent.2020 Mar;14(2):288-293. doi: 10.1055/s-0040-1710141.Epub 2020-06-05.

デュシェンヌ型筋ジストロフィーの改善に関連した世代を超えたエピジェネティックな調節

Trans-generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy.
  • Julie Martone
  • Michela Lisi
  • Francesco Castagnetti
  • Alessandro Rosa
  • Valerio Di Carlo
  • Enrique Blanco
  • Adriano Setti
  • Davide Mariani
  • Alessio Colantoni
  • Tiziana Santini
  • Lucia Perone
  • Luciano Di Croce
  • Irene Bozzoni
  • EMBO Mol Med.2020 Jun;:e12063. doi: 10.15252/emmm.202012063.Epub 2020-06-29.

アルツハイマー病のトラジェクトリーにまたがる介護フェーズとそれに対応する介護者支援ニーズを明らかにするためのグラウンデッド・セオリー研究

A grounded theory study to identify caregiving phases and support needs across the Alzheimer's disease trajectory.
  • Kristina M Kokorelias
  • Monique A M Gignac
  • Gary Naglie
  • Nira Rittenberg
  • Jennifer MacKenzie
  • Samantha D'Souza
  • Jill I Cameron
  • Disabil Rehabil.2020 Jul;:1-10. doi: 10.1080/09638288.2020.1788655.Epub 2020-07-20.

グルココルチコイドと血清およびグルココルチコイド誘導性キナーゼ1は、在来腸におけるCFTRの強力な調節因子である：ストレス誘発性下痢の意味合い

Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea.
  • Md Kaimul Ahsan
  • Leandra Figueroa-Hall
  • Vanessa Baratta
  • Rolando Garcia-Milian
  • TuKiet T Lam
  • Kazi Hoque
  • Pedro J Salas
  • Nadia A Ameen
  • Am. J. Physiol. Gastrointest. Liver Physiol..2020 Aug;319(2):G121-G132. doi: 10.1152/ajpgi.00076.2020.Epub 2020-06-22.

NCI指定がんセンター内でのたばこ止めプログラムの実施を評価するためのRE-AIMフレームワークの実用的な適用

Pragmatic Application of the RE-AIM Framework to Evaluate the Implementation of Tobacco Cessation Programs Within NCI-Designated Cancer Centers.
  • Heather D'Angelo
  • Alex T Ramsey
  • Betsy Rolland
  • Li-Shiun Chen
  • Steven L Bernstein
  • Lisa M Fucito
  • Monica Webb Hooper
  • Robert Adsit
  • Danielle Pauk
  • Marika S Rosenblum
  • Paul M Cinciripini
  • Anne Joseph
  • Jamie S Ostroff
  • Graham W Warren
  • Michael C Fiore
  • Timothy B Baker
  • Front Public Health.2020;8:221. doi: 10.3389/fpubh.2020.00221.Epub 2020-06-12.

真菌フィターゼのゲノムスケールでの特性評価、およびβ-プロペラフィターゼとヒスチジン酸ホスファターゼの比較研究

Genome-Scale Characterization of Fungal Phytases and a Comparative Study Between Beta-Propeller Phytases and Histidine Acid Phosphatases.
  • Roberta Corsino Ferreira
  • Murillo Peterlini Tavares
  • Túlio Morgan
  • Yan da Silva Clevelares
  • Marina Quádrio Raposo Branco Rodrigues
  • Maria Catarina Megumi Kasuya
  • Tiago Antônio de Oliveira Mendes
  • Valéria Monteze Guimarães
  • Appl. Biochem. Biotechnol..2020 May;10.1007/s12010-020-03309-7. doi: 10.1007/s12010-020-03309-7.Epub 2020-05-06.

ウィタフェリンAは、2孔ドメインカリウム（K2P9）チャネルTASK-3を阻害することで乳がん細胞の増殖を抑制します

Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3.
  • Rafael Zúñiga
  • Guierdy Concha
  • Angel Cayo
  • Rocio Cikutović-Molina
  • Bárbara Arevalo
  • Wendy González
  • Marcelo A Catalán
  • Leandro Zúñiga
  • Biomed. Pharmacother..2020 Jun;129:110383. S0753-3322(20)30576-X. doi: 10.1016/j.biopha.2020.110383.Epub 2020-06-17.

網膜下に注入された半導体ポリマーナノ粒子は、網膜ジストロフィーのラットモデルにおける視力を回復させる

Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy.
  • José Fernando Maya-Vetencourt
  • Giovanni Manfredi
  • Maurizio Mete
  • Elisabetta Colombo
  • Mattia Bramini
  • Stefano Di Marco
  • Dmytro Shmal
  • Giulia Mantero
  • Michele Dipalo
  • Anna Rocchi
  • Mattia L DiFrancesco
  • Ermanno D Papaleo
  • Angela Russo
  • Jonathan Barsotti
  • Cyril Eleftheriou
  • Francesca Di Maria
  • Vanessa Cossu
  • Fabio Piazza
  • Laura Emionite
  • Flavia Ticconi
  • Cecilia Marini
  • Gianmario Sambuceti
  • Grazia Pertile
  • Guglielmo Lanzani
  • Fabio Benfenati
  • Nat Nanotechnol.2020 Jun;10.1038/s41565-020-0696-3. doi: 10.1038/s41565-020-0696-3.Epub 2020-06-29.

化学療法を受けている乳がん患者における音楽介入のQOLへの影響。無作為化臨床試験

Impact of a Music Intervention on Quality of Life in Breast Cancer Patients Undergoing Chemotherapy: A Randomized Clinical Trial.
  • Talita Uchoa Lima
  • Ed Carlos Rey Moura
  • Caio Márcio Barros de Oliveira
  • Rachel Jorge Dino Cossetti Leal
  • João Nogueira Neto
  • Emanuel Cabral Pereira
  • Raniere Victor Braga Nascimento
  • Eduardo José Silva Gomes de Oliveira
  • Plínio da Cunha Leal
  • Integr Cancer Ther.2020 Jan-Dec;19:1534735420938430. doi: 10.1177/1534735420938430.

オリゴデンドロサイト前駆細胞の破壊は、アルツハイマー病のトリプルトランスジェニックマウスモデルにおける病理の初期徴候である

Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease.
  • Ilaria Vanzulli
  • Maria Papanikolaou
  • Irene Chacon De-La-Rocha
  • Francesca Pieropan
  • Andrea D Rivera
  • Diego Gomez-Nicola
  • Alexei Verkhratsky
  • José Julio Rodríguez
  • Arthur M Butt
  • Neurobiol. Aging.2020 Jun;94:130-139. S0197-4580(20)30185-8. doi: 10.1016/j.neurobiolaging.2020.05.016.Epub 2020-06-07.

ニコチンアミドN-メチルトランスフェラーゼは、代謝リプログラミングとWarburg効果の促進により、ヒト食道扁平上皮癌における5-フルオロウラシル感受性を低下させる

Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect.
  • Yanyan Cui
  • Dawei Yang
  • Wenjie Wang
  • Luyu Zhang
  • Hongtao Liu
  • Shanshan Ma
  • Wenna Guo
  • Minghao Yao
  • Kun Zhang
  • Wencai Li
  • Yanting Zhang
  • Fangxia Guan
  • Mol. Carcinog..2020 Aug;59(8):940-954. doi: 10.1002/mc.23209.Epub 2020-05-04.

精神科患者と学生のコントロールにおけるスマートフォンベースの生態学的瞬間評価（EMA）。現実世界の実現可能性研究

Smartphone-based ecological momentary assessment (EMA) in psychiatric patients and student controls: A real-world feasibility study.
  • Alejandro Porras-Segovia
  • Rosa María Molina-Madueño
  • Sofian Berrouiguet
  • Jorge López-Castroman
  • Maria Luisa Barrigón
  • María Sandra Pérez-Rodríguez
  • José Heliodoro Marco
  • Isaac Díaz-Oliván
  • Santiago de León
  • Philippe Courtet
  • Antonio Artés-Rodríguez
  • Enrique Baca-García
  • J Affect Disord.2020 Sep;274:733-741. S0165-0327(20)30440-7. doi: 10.1016/j.jad.2020.05.067.Epub 2020-05-26.

hPSC由来の肺オルガノイドを用いた候補COVID-19治療薬の同定

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids.
  • Yuling Han
  • Liuliu Yang
  • Xiaohua Duan
  • Fuyu Duan
  • Benjamin E Nilsson-Payant
  • Tomer M Yaron
  • Pengfei Wang
  • Xuming Tang
  • Tuo Zhang
  • Zeping Zhao
  • Yaron Bram
  • David Redmond
  • Sean Houghton
  • Duc Nguyen
  • Dong Xu
  • Xing Wang
  • Skyler Uhl
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バイタルサイン。産後の抑うつ症状と周産期うつ病についてのプロバイダーの話し合い-米国、2018年

Vital Signs: Postpartum Depressive Symptoms and Provider Discussions About Perinatal Depression - United States, 2018.
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  • Shanna Cox
  • Denise V D'Angelo Mph
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  • Heather D Tevendale
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  • MMWR Morb. Mortal. Wkly. Rep..2020 May;69(19):575-581. doi: 10.15585/mmwr.mm6919a2.Epub 2020-05-15.

低酸素状態に曝露したDcytbノックアウトマウスでは、十二指腸還元酵素活性と脾臓鉄貯蔵量が低下し、赤血球造血が異常になる

Duodenal reductase activity and spleen iron stores are reduced and erythropoiesis is abnormal in Dcytb knockout mice exposed to hypoxic conditions.
  • Jeehyea Choi
  • Patarabutr Masaratana
  • Gladys O Latunde-Dada
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  • J. Nutr..2012 Nov;142(11):1929-34. jn.112.160358. doi: 10.3945/jn.112.160358.Epub 2012-09-18.

UPLC-MS/MSによるヒト血漿中の重水素化ボルチオキセチンとその主要代謝物の同時定量と健康なボランティアを対象とした薬物動態試験への応用

Simultaneous determination of deuterated vortioxetine and its major metabolite in human plasma by UPLC-MS/MS and application to a pharmacokinetic study in healthy volunteers.
  • Yingyue Yi
  • Guanghui Ren
  • Ming Zheng
  • Di Zhao
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  • Yang Lu
  • J. Chromatogr. B Analyt. Technol. Biomed. Life Sci..2020 Feb;1138:121955. S1570-0232(19)31662-9. doi: 10.1016/j.jchromb.2019.121955.Epub 2019-12-23.

入院患者における精神病性うつ病。入院患者における精神病性うつ病と非精神病性うつ病の縦断的転帰。臨床重症度における抑うつ症状の役割

Psychotic depression in hospitalized patients: Longitudinal outcomes of psychotic vs. nonpsychotic depression among inpatients: The role of depressive symptoms on clinical severity.
  • Felipe Bauer Pinto da Costa
  • Eduardo Trachtenberg
  • Aline Boni
  • Lucas Primo de Carvalho Alves
  • Pedro Vieira da Silva Magalhães
  • Neusa Sica Rocha
  • J Psychiatr Res.2020 Jun;129:73-79. S0022-3956(20)30280-6. doi: 10.1016/j.jpsychires.2020.06.002.Epub 2020-06-02.

感情障害に対するトランス診断ガイド付きインターネット配信プロトコルの有効性と、専門ケアにおける通常の治療との比較。ランダム化比較試験

Effectiveness of a Transdiagnostic Guided Internet-Delivered Protocol for Emotional Disorders Versus Treatment as Usual in Specialized Care: Randomized Controlled Trial.
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  • Amanda Díaz-García
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  • J. Med. Internet Res..2020 Jul;22(7):e18220. v22i7e18220. doi: 10.2196/18220.Epub 2020-07-07.

カメルーン南西部における予防接種拡大プログラムの下での予防接種の適用範囲

Vaccination Coverage Under the Expanded Program on Immunization in South West Cameroon.
  • Bestina Forkwa Ewang
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  • Samuel Nambile Cumber
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  • Brenda Mbouamba Yankam
  • Cho Sabastine Anye
  • Jacintha Rebang Achu
  • Bih Moki Suh
  • Mildred Njoache Nkeng
  • Rosette Boseme Nzoyom
  • Joyce Mahlako Tsoka-Gwegweni
  • Eric Achidi Akum
  • Int J MCH AIDS.2020;9(2):242-251. IJMA-9-242. doi: 10.21106/ijma.308.Epub 2020-07-09.

構造的に拘束されたシクロプロパン含有ビルディングブロックを有する大環状ペプチドライブラリーは、ホスホグリセリン酸ムターゼのチオール非依存性阻害剤を導く

A macrocyclic peptide library with a structurally constrained cyclopropane-containing building block leads to thiol-independent inhibitors of phosphoglycerate mutase.
  • Rika Okuma
  • Tomoki Kuwahara
  • Takafumi Yoshikane
  • Mizuki Watanabe
  • Patricia Dranchak
  • James Inglese
  • Satoshi Shuto
  • Yuki Goto
  • Hiroaki Suga
  • Chem Asian J.2020 Jul;doi: 10.1002/asia.202000700.Epub 2020-07-07.

ケモカイン-ケモカイン受容体軸の応用は、大腸癌患者におけるサイトカイン誘導キラー細胞の腫瘍標的遊走能を増加させる

Application of the chemokine-chemokine receptor axis increases the tumor-targeted migration ability of cytokine-induced killer cells in patients with colorectal cancer.
  • Yunlian Zou
  • Jianhua Liang
  • Danyang Li
  • Jingjing Fang
  • Linping Wang
  • Jinli Wang
  • Jinping Zhang
  • Qiang Guo
  • Xinmin Yan
  • Hui Tang
  • Oncol Lett.2020 Jul;20(1):123-134. OL-0-0-11539. doi: 10.3892/ol.2020.11539.Epub 2020-04-15.

NSC-34細胞の分化は、NGF受容体p75、グルタミナーゼ、NCAM L1の発現、ミトコンドリアの活性化、脂肪酸の介入に対する感受性によって特徴づけられる

Differentiation of NSC-34 cells is characterized by expression of NGF receptor p75, glutaminase and NCAM L1, activation of mitochondria, and sensitivity to fatty acid intervention.
  • Gerburg Keilhoff
  • Ricardo Pirex Mbou
  • Benjamin Lucas
  • Acta Histochem..2020 Jul;122(5):151574. S0065-1281(20)30073-8. doi: 10.1016/j.acthis.2020.151574.Epub 2020-06-15.