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日本語AIでPubMedを検索

歯科医師情報サイトTOP / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
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2020年07月 みんなが読んでいる論文

ネコノミゲノムの染色体レベルでのアセンブリーにより、遺伝子の重複とゲノムサイズの可塑性が明らかになった

A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity.
  • Timothy P Driscoll
  • Victoria I Verhoeve
  • Joseph J Gillespie
  • J Spencer Johnston
  • Mark L Guillotte
  • Kristen E Rennoll-Bankert
  • M Sayeedur Rahman
  • Darren Hagen
  • Christine G Elsik
  • Kevin R Macaluso
  • Abdu F Azad
  • BMC Biol..2020 Jun;18(1):70. 10.1186/s12915-020-00802-7. doi: 10.1186/s12915-020-00802-7.Epub 2020-06-19.

海藻Acanthophora spiciferaのバイオエンジニアリング金ナノ粒子の医薬用途への応用：抗酸化作用、抗菌作用、抗がん作用

Bioengineered gold nanoparticles from marine seaweed Acanthophora spicifera for pharmaceutical uses: antioxidant, antibacterial, and anticancer activities.
  • Baskaran Babu
  • Subramanian Palanisamy
  • Manoharan Vinosha
  • Ravichandran Anjali
  • Ponnuchamy Kumar
  • Boomi Pandi
  • Mehdi Tabarsa
  • SangGuan You
  • Narayanasamy Marimuthu Prabhu
  • Bioprocess Biosyst Eng.2020 Jul;10.1007/s00449-020-02408-3. doi: 10.1007/s00449-020-02408-3.Epub 2020-07-18.

ZENKER'S DIVERTICULUMに対するFLEXIBLE ENDOSCOPIC MYOTOMYの実践パターン、技術、および結果：レトロスペクティブ、多施設研究

PRACTICE PATTERNS, TECHNIQUES, AND OUTCOMES OF FLEXIBLE ENDOSCOPIC MYOTOMY FOR ZENKER'S DIVERTICULUM: RETROSPECTIVE, MULTI-CENTER STUDY.
  • Chetan Mittal
  • David Diehl
  • Peter Draganov
  • Laith Jamil
  • Ammara Khalid
  • Harshit Khara
  • Vikas Khullar
  • Ryan Law
  • Simon Lo
  • Abraham Mathew
  • Ebrahim Mirakhor
  • Alireza Sedarat
  • Neil Sharma
  • Setareh Sharzehi
  • Anna Tavvakoli
  • Adarsh Thaker
  • Nirav Thosani
  • Dennis Yang
  • Christina Zelt
  • Mihir S Wagh
  • Endoscopy.2020 Jul;doi: 10.1055/a-1219-4516.Epub 2020-07-14.

ラット脳の背側海馬にA2AR-TrkBヘテロ受容体複合体が存在することを証明した。老化に伴うA2ARとTrkBの相互作用の可能性

Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing.
  • Michael Di Palma
  • Stefano Sartini
  • Davide Lattanzi
  • Riccardo Cuppini
  • Mariana Pita-Rodriguez
  • Yoslandy Diaz-Carmenate
  • Manuel Narvaez
  • Kjell Fuxe
  • Dasiel O Borroto-Escuela
  • Patrizia Ambrogini
  • Mech. Ageing Dev..2020 Jun;190:111289. S0047-6374(20)30085-3. doi: 10.1016/j.mad.2020.111289.Epub 2020-06-18.

医師による新しい経口抗糖尿病薬の採用とメディケアおよびメディケイドの薬剤費との関連

Association between physician adoption of a new oral anti-diabetic medication and Medicare and Medicaid drug spending.
  • Ilinca D Metes
  • Lingshu Xue
  • Chung-Chou H Chang
  • Haiden A Huskamp
  • Walid F Gellad
  • Wei-Hsuan Lo-Ciganic
  • Niteesh K Choudhry
  • Seth Richards-Shubik
  • Hasan Guclu
  • Julie M Donohue
  • BMC Health Serv Res.2019 Oct;19(1):703. 10.1186/s12913-019-4520-4. doi: 10.1186/s12913-019-4520-4.Epub 2019-10-16.

蛋白質を用いて、遺伝子組換えとKRAS/RAF-RBDの相互作用を同時にモニタリングするデュアルパラメトリックアッセイの開発を行っています

Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring.
  • Kari Kopra
  • Emmiliisa Vuorinen
  • Maria Abreu-Blanco
  • Qi Wang
  • Ville Eskonen
  • William Gillette
  • Arto T Pulliainen
  • Matthew Holderfield
  • Harri Härmä
  • Anal. Chem..2020 04;92(7):4971-4979. doi: 10.1021/acs.analchem.9b05126.Epub 2020-03-09.

間葉系幹細胞を用いた治療は、血管新生型高血圧を改善し、対側腎臓のナトリウム排泄能力を維持する

Treatment with Mesenchymal Stem Cells Improves Renovascular Hypertension and Preserves the Ability of the Contralateral Kidney to Excrete Sodium.
  • Vanessa Araujo Varela
  • Elizabeth B Oliveira-Sales
  • Edgar Maquigussa
  • Fernanda T Borges
  • Pedro P Gattai
  • Antonio da S Novaes
  • Caroline G Shimoura
  • Ruy R Campos
  • Mirian A Boim
  • Kidney Blood Press. Res..2019;44(6):1404-1415. 000503346. doi: 10.1159/000503346.Epub 2019-10-31.

肥大型閉塞性心筋症に対するアルコール中隔アブレーション後に新たに発症した伝導障害を有するハイリスク患者における電気生理学的研究の役割

The role of electrophysiologic study in high-risk patients with new-onset conduction disturbances following alcohol septal ablation for hypertrophic obstructive cardiomyopathy.
  • Patrick Badertscher
  • Thomas A Turnage
  • Valerian Fernandes
  • Christopher Nielsen
  • Michael R Gold
  • J. Cardiovasc. Electrophysiol..2020 Jul;doi: 10.1111/jce.14670.Epub 2020-07-13.

レニン-アンジオテンシン系遮断薬はラットの神経障害性疼痛の末梢と中枢の両方の成分を調節する。カルシトニン遺伝子関連ペプチド、サブスタンスP、一酸化窒素の役割

Renin-Angiotensin System Blockade modulates both the peripheral and central component of neuropathic pain in rats: Role of Calcitonin gene-related peptide, substance P and nitric oxide.
  • Nora Hegazy
  • Samar Rezq
  • Ahmed Fahmy
  • Basic Clin. Pharmacol. Toxicol..2020 Jun;doi: 10.1111/bcpt.13453.Epub 2020-06-15.

マルチオミクスアプローチにより、肺胞マクロファージにおけるナノ材料の毒性と構造活性の関係を明らかにした

A multi-omics approach reveals mechanisms of nanomaterial toxicity and structure-activity relationships in alveolar macrophages.
  • Anne Bannuscher
  • Isabel Karkossa
  • Sophia Buhs
  • Peter Nollau
  • Katja Kettler
  • Mihaela Balas
  • Anca Dinischiotu
  • Bryan Hellack
  • Martin Wiemann
  • Andreas Luch
  • Martin von Bergen
  • Andrea Haase
  • Kristin Schubert
  • Nanotoxicology.2020 03;14(2):181-195. doi: 10.1080/17435390.2019.1684592.Epub 2019-11-27.

中国人患者のアッシャー症候群の原因遺伝子における複合ヘテロ接合性の新規変異を標的とした次世代シークエンシングにより特定した

Targeted Next-Generation Sequencing Identified Novel Compound Heterozygous Variants in the Gene Causing Usher Syndrome Type ID in a Chinese Patient.
  • Lianmei Zhang
  • Jingliang Cheng
  • Qi Zhou
  • Md Asaduzzaman Khan
  • Jiewen Fu
  • Chengxia Duan
  • Suan Sun
  • Hongbin Lv
  • Junjiang Fu
  • Front Genet.2020;11:422. doi: 10.3389/fgene.2020.00422.Epub 2020-04-30.

オルニチンアミノトランスフェラーゼ遺伝子のc.425-1G>A変異により、高オルニチン血症を伴う脈絡膜および網膜の回旋性萎縮を呈した最初の症例である

First report of c.425-1G>A mutation in ornithine aminotransferase gene causing gyrate atrophy of the choroid and retina with hyperornithinemia.
  • Hossein Jalali
  • Mojtaba Najafi
  • Atefeh Khoshaeen
  • Mohammad Reza Mahdavi
  • Mahan Mahdavi
  • Eur J Ophthalmol.2020 May;:1120672120921734. doi: 10.1177/1120672120921734.Epub 2020-05-17.

コンゴ民主共和国イディオファにおける5歳未満の子どもの下痢の減少に対する衛生設備の改善の効果：クラスター無作為化試験

Effects of improved sanitation on diarrheal reduction for children under five in Idiofa, DR Congo: a cluster randomized trial.
  • Seungman Cha
  • JaeEun Lee
  • DongSik Seo
  • Byoung Mann Park
  • Paul Mansiangi
  • Kabore Bernard
  • Guy Jerome Nkay Mulakub-Yazho
  • Honore Minka Famasulu
  • Infect Dis Poverty.2017 Sep;6(1):137. 10.1186/s40249-017-0351-x. doi: 10.1186/s40249-017-0351-x.Epub 2017-09-19.

単純ヘルペスウイルスの免疫回避タンパク質ICP47（US12）の新規転写制御配列と因子の解析

Novel transcription regulatory sequences and factors of the immune evasion protein ICP47 (US12) of herpes simplex viruses.
  • Jun-Ting Cheng
  • Ying-Ying Wang
  • Lin-Zhong Zhu
  • Ying Zhang
  • Wen-Qi Cai
  • Zi-Wen Han
  • Yang Zhou
  • Xian-Wang Wang
  • Xiao-Chun Peng
  • Ying Xiang
  • Hui-Yu Yang
  • Shu-Zhong Cui
  • Zhaowu Ma
  • Bing-Rong Liu
  • Hong-Wu Xin
  • Virol. J..2020 07;17(1):101. 10.1186/s12985-020-01365-3. doi: 10.1186/s12985-020-01365-3.Epub 2020-07-10.

抗マラリア薬耐性がDRCにおけるサルシパルム原虫の遺伝的構造に与える影響

The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC.
  • Robert Verity
  • Ozkan Aydemir
  • Nicholas F Brazeau
  • Oliver J Watson
  • Nicholas J Hathaway
  • Melchior Kashamuka Mwandagalirwa
  • Patrick W Marsh
  • Kyaw Thwai
  • Travis Fulton
  • Madeline Denton
  • Andrew P Morgan
  • Jonathan B Parr
  • Patrick K Tumwebaze
  • Melissa Conrad
  • Philip J Rosenthal
  • Deus S Ishengoma
  • Jeremiah Ngondi
  • Julie Gutman
  • Modest Mulenga
  • Douglas E Norris
  • William J Moss
  • Benedicta A Mensah
  • James L Myers-Hansen
  • Anita Ghansah
  • Antoinette K Tshefu
  • Azra C Ghani
  • Steven R Meshnick
  • Jeffrey A Bailey
  • Jonathan J Juliano
  • Nat Commun.2020 04;11(1):2107. 10.1038/s41467-020-15779-8. doi: 10.1038/s41467-020-15779-8.Epub 2020-04-30.

TocilizumabによるIL-6受容体遮断は、WAG/Rijラットの不在てんかんモデルにおいて、抗てんかん作用および抗てんかん作用を示した

IL-6 Receptor Blockade by Tocilizumab Has Anti-absence and Anti-epileptogenic Effects in the WAG/Rij Rat Model of Absence Epilepsy.
  • Antonio Leo
  • Valentina Nesci
  • Martina Tallarico
  • Nicola Amodio
  • Eugenia M Gallo Cantafio
  • Giovambattista De Sarro
  • Andrew Constanti
  • Emilio Russo
  • Rita Citraro
  • Neurotherapeutics.2020 Jul;10.1007/s13311-020-00893-8. doi: 10.1007/s13311-020-00893-8.Epub 2020-07-17.

ベイズ推論とマルチエンサンブルマルコフ状態モデルを用いた実験データとアポミオグロビンのシミュレーションされたアンサンブルの再構築

Reconciling Simulated Ensembles of Apomyoglobin with Experimental Hydrogen/Deuterium Exchange Data Using Bayesian Inference and Multiensemble Markov State Models.
  • Hongbin Wan
  • Yunhui Ge
  • Asghar Razavi
  • Vincent A Voelz
  • J Chem Theory Comput.2020 Feb;16(2):1333-1348. doi: 10.1021/acs.jctc.9b01240.Epub 2020-01-23.

前立腺肥大症に対するデュタステリド投与後のタダラフィルとソリフェナシンによる下部尿路症状と性機能障害の改善

Improvement of the symptoms of lower urinary tract and sexual dysfunction with tadalafil and solifenacin after the treatment of benign prostatic hyperplasia with dutasteride.
  • Kirill V Kosilov
  • Irina G Kuzina
  • Vladimir Kuznetsov
  • Ekaterina K Kosilova
  • Prostate Int.2020 Jun;8(2):78-84. S2287-8882(20)30007-6. doi: 10.1016/j.prnil.2019.11.005.Epub 2020-02-25.

閉経後の骨粗鬆症の管理に更年期ホルモン療法の役割はあるのか？

Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis?
  • S Rozenberg
  • N Al-Daghri
  • M Aubertin-Leheudre
  • M-L Brandi
  • A Cano
  • P Collins
  • C Cooper
  • A R Genazzani
  • T Hillard
  • J A Kanis
  • J-M Kaufman
  • I Lambrinoudaki
  • A Laslop
  • E McCloskey
  • S Palacios
  • D Prieto-Alhambra
  • J-Y Reginster
  • R Rizzoli
  • G Rosano
  • F Trémollieres
  • N C Harvey
  • Osteoporos Int.2020 Jul;10.1007/s00198-020-05497-8. doi: 10.1007/s00198-020-05497-8.Epub 2020-07-08.

マラリア寄生虫におけるプラスチッドの生合成には、Clpタンパク質分解系の相互作用と触媒活性が必要であることが明らかになった

Plastid biogenesis in malaria parasites requires the interactions and catalytic activity of the Clp proteolytic system.
  • Anat Florentin
  • Dylon R Stephens
  • Carrie F Brooks
  • Rodrigo P Baptista
  • Vasant Muralidharan
  • Proc. Natl. Acad. Sci. U.S.A..2020 Jun;117(24):13719-13729. 1919501117. doi: 10.1073/pnas.1919501117.Epub 2020-06-01.

サーマルバイオプリンティングは乳がん細胞におけるLUCAT1, IL6, CCL26, NRN1L遺伝子の発現を大幅に変化させ、重要な抗がん剤耐性経路の大規模なリン酸化を引き起こす

Thermal Bioprinting Causes Ample Alterations of Expression of LUCAT1, IL6, CCL26, and NRN1L Genes and Massive Phosphorylation of Critical Oncogenic Drug Resistance Pathways in Breast Cancer Cells.
  • Aleli Campbell
  • Jonathon E Mohl
  • Denisse A Gutierrez
  • Armando Varela-Ramirez
  • Thomas Boland
  • Front Bioeng Biotechnol.2020;8:82. doi: 10.3389/fbioe.2020.00082.Epub 2020-02-21.

薬物乱用の既往のない慢性片頭痛患者は，特異な白質繊維束プロファイルが特徴である．

Patients with chronic migraine without history of medication overuse are characterized by a peculiar white matter fiber bundle profile.
  • Gianluca Coppola
  • Antonio Di Renzo
  • Emanuele Tinelli
  • Barbara Petolicchio
  • Cherubino Di Lorenzo
  • Vincenzo Parisi
  • Mariano Serrao
  • Valentina Calistri
  • Stefano Tardioli
  • Gaia Cartocci
  • Francesca Caramia
  • Vittorio Di Piero
  • Francesco Pierelli
  • J Headache Pain.2020 Jul;21(1):92. 10.1186/s10194-020-01159-6. doi: 10.1186/s10194-020-01159-6.Epub 2020-07-18.

CTNNB1 p.S45P変異を有するデスモイド型線維腫症を頸部-胸郭アプローチで切除した。症例報告と文献レビュー

Resection of a desmoid-type fibromatosis with a CTNNB1 p.S45P mutation using a cervico-thoracic approach: A case report and literature review.
  • Ryosuke Sato
  • Nobuyuki Bandoh
  • Takashi Goto
  • Akihiro Uemura
  • Nobuyuki Inoue
  • Yuki Otomo
  • Hiroshi Nakano
  • Tomomi Yamaguchi
  • Yasutaka Kato
  • Hiroshi Nishihara
  • Hidehiro Takei
  • Yasuaki Harabuchi
  • Auris Nasus Larynx.2020 Jun;S0385-8146(20)30120-6. doi: 10.1016/j.anl.2020.05.004.Epub 2020-06-03.

少なくとも1回の流産のための掻爬術を経験したことのある女性における、流産のための拡張術および掻爬術後のヒアルロン酸ゲル塗布後の42ヵ月後の妊娠および新生児の転帰：無作為化比較試験のフォローアップ

Pregnancy and neonatal outcomes 42 months after application of hyaluronic acid gel following dilation and curettage for miscarriage in women who have experienced at least one previous curettage: follow-up of a randomized controlled trial.
  • Angelo B Hooker
  • Robert A de Leeuw
  • Jos W R Twisk
  • Hans A M Brölmann
  • Judith A F Huirne
  • Fertil. Steril..2020 Jul;S0015-0282(20)30349-6. doi: 10.1016/j.fertnstert.2020.04.021.Epub 2020-07-10.

局所特異的差異DNAメチル化と尿中ヒ素。低～中等度のヒ素曝露を有する成人の血液中のエピゲノムワイド関連研究

Locus-Specific Differential DNA Methylation and Urinary Arsenic: An Epigenome-Wide Association Study in Blood among Adults with Low-to-Moderate Arsenic Exposure.
  • Anne K Bozack
  • Arce Domingo-Relloso
  • Karin Haack
  • Mary V Gamble
  • Maria Tellez-Plaza
  • Jason G Umans
  • Lyle G Best
  • Joseph Yracheta
  • Matthew O Gribble
  • Andres Cardenas
  • Kevin A Francesconi
  • Walter Goessler
  • Wan-Yee Tang
  • M Daniele Fallin
  • Shelley A Cole
  • Ana Navas-Acien
  • Environ. Health Perspect..2020 Jun;128(6):67015. doi: 10.1289/EHP6263.Epub 2020-06-30.

臨床的に有意な記憶力低下が起こる前の認知機能障害者の心室異常を調べるために、表面ベースの形態測定法を適用した

Applying surface-based morphometry to study ventricular abnormalities of cognitively unimpaired subjects prior to clinically significant memory decline.
  • Qunxi Dong
  • Wen Zhang
  • Cynthia M Stonnington
  • Jianfeng Wu
  • Boris A Gutman
  • Kewei Chen
  • Yi Su
  • Leslie C Baxter
  • Paul M Thompson
  • Eric M Reiman
  • Richard J Caselli
  • Yalin Wang
  • Neuroimage Clin.2020 Jul;27:102338. S2213-1582(20)30175-3. doi: 10.1016/j.nicl.2020.102338.Epub 2020-07-05.

上顎臼歯部歯内療法手術における止血剤。ポリテトラフルオロエチレン（PTFE）ストリップをエピネフリン含浸ガーゼの補助として使用した場合と塩化アルミニウムを使用した場合の無作為化比較パイロット試験

Hemostatic agents in endodontic surgery of maxillary molars: A randomized controlled pilot study of polytetrafluoroethylene (PTFE) strips as an adjunct to epinephrine impregnated gauze versus aluminum chloride.
  • D Peñarrocha-Oltra
  • D Soto-Peñaloza
  • M Peñarrocha-Diago
  • J Cervera-Ballester
  • G Cabanes-Gumbau
  • M Peñarrocha-Diago
  • Med Oral Patol Oral Cir Bucal.2020 Jul;23652. doi: 10.4317/medoral.23652.Epub 2020-07-19.

肝オステオポンチンは、加齢性非アルコール性脂肪性肝疾患の進行を抑制するために必要である

Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease.
  • Beatriz Gómez-Santos
  • Diego Saenz de Urturi
  • Maitane Nuñez-García
  • Francisco Gonzalez-Romero
  • Xabier Buque
  • Igor Aurrekoetxea
  • Virginia Gutiérrez de Juan
  • Maria J Gonzalez-Rellan
  • Carmelo García-Monzón
  • Águeda González-Rodríguez
  • Lorena Mosteiro
  • Gaizka Errazti
  • Patricia Mifsut
  • Sonia Gaztambide
  • Luis Castaño
  • Cesar Martin
  • Rubén Nogueiras
  • María L Martinez-Chantar
  • Wing-Kin Syn
  • Patricia Aspichueta
  • Aging Cell.2020 Jul;:e13183. doi: 10.1111/acel.13183.Epub 2020-07-07.

ライゲーションと制限酵素に依存しないクローニング技術：インフルエンザ逆遺伝学システムにおけるハード・トゥ・クローン遺伝子セグメントのクローニングのための従来法への代替技術

A ligation and restriction enzyme independent cloning technique: an alternative to conventional methods for cloning hard-to-clone gene segments in the influenza reverse genetics system.
  • Sushant Bhat
  • Dagmara Bialy
  • Joshua E Sealy
  • Jean-Remy Sadeyen
  • Pengxiang Chang
  • Munir Iqbal
  • Virol. J..2020 06;17(1):82. 10.1186/s12985-020-01358-2. doi: 10.1186/s12985-020-01358-2.Epub 2020-06-23.

パーキンソン病の進行マーカー・イニシアチブ（PPMI）における非顕在性LRRK2およびGBA変異キャリアの臨床的およびドーパミントランスポーターイメージング特性：横断的研究

Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study.
  • Tanya Simuni
  • Liz Uribe
  • Hyunkeun Ryan Cho
  • Chelsea Caspell-Garcia
  • Christopher S Coffey
  • Andrew Siderowf
  • John Q Trojanowski
  • Leslie M Shaw
  • John Seibyl
  • Andrew Singleton
  • Arthur W Toga
  • Doug Galasko
  • Tatiana Foroud
  • Duygu Tosun
  • Kathleen Poston
  • Daniel Weintraub
  • Brit Mollenhauer
  • Caroline M Tanner
  • Karl Kieburtz
  • Lana M Chahine
  • Alyssa Reimer
  • Samantha J Hutten
  • Susan Bressman
  • Kenneth Marek
  • Lancet Neurol.2020 01;19(1):71-80. S1474-4422(19)30319-9. doi: 10.1016/S1474-4422(19)30319-9.Epub 2019-10-31.

ハンガリーの乳癌患者の現代的な乳房外科手術治療に対するニーズの評価。 500人の患者を対象としたアンケート調査

Assessing the needs of Hungarian breast cancer patients for modern oncoplastic breast surgical treatment. Questionnaire study of 500 patients
  • Bence Dorogi
  • Tamás Mátrai
  • Mihály Újhelyi
  • István Kenessey
  • Péter Kelemen
  • Ákos Sávolt
  • Orsolya Huszár
  • Orsolya Ping
  • Dávid Pukancsik
  • Zoltán Mátrai
  • Orv Hetil.2020 07;161(29):1221-1228. doi: 10.1556/650.2020.31768.

パルス磁化はカリブ海のトゲエビ、Panulirus argusの中枢神経系における遺伝子発現の違いを誘発する

Pulse magnetization elicits differential gene expression in the central nervous system of the Caribbean spiny lobster, Panulirus argus.
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オクトレオチド長時間作用性放出薬（サンドスタチンLAR）の新剤形および旧剤形に対する看護師および患者の全体的満足度の評価。フランスの観察研究

Evaluation of Nurses' and Patients' Overall Satisfaction with New and Previous Formulations of Octreotide Long-acting Release (Sandostatin LAR): A French Observational Study.
  • Brigitte Delemer
  • Thierry Nguyen-Tan-Hon
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  • Benedicte Decoudier
  • Ségolène Bisot-Locard
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ヒト細胞株由来マクロファージにおけるヒストン脱アセチル化酵素1による防御遺伝子のエピジェネティック制御は、リーシュマニア・ドノヴァニの細胞内生存を促進する

Epigenetic regulation of defense genes by histone deacetylase1 in human cell line-derived macrophages promotes intracellular survival of Leishmania donovani.
  • Gargi Roy
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食事性ミオイノシトール補給がインスリン抵抗性および妊娠糖尿病の予防に及ぼす影響：無作為化比較試験の研究プロトコール

Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: study protocol for a randomized controlled trial.
  • George Asimakopoulos
  • Vasilios Pergialiotis
  • Eleni Anastasiou
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  • Mariana Theodora
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  • Aggela Kallergi
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SARS-CoV2における進化する地理的多様性と、再利用薬剤候補を標的とした複製酵素3CLのインシリコ解析

Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CL targeting repurposed drug candidates.
  • Nitin Chitranshi
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  • Rashi Rajput
  • Angela Godinez
  • Kanishka Pushpitha
  • Ting Shen
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水性メイラード反応モデル系におけるアクリルアミド、β-カルボリン複素環アミン及び高度な糖化末端生成物の同時生成

Simultaneous generation of acrylamide, β-carboline heterocyclic amines and advanced glycation ends products in an aqueous Maillard reaction model system.
  • Wei Quan
  • Yong Li
  • Ye Jiao
  • Chaoyi Xue
  • Guoping Liu
  • Zhaojun Wang
  • Zhiyong He
  • Fang Qin
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  • Food Chem.2020 Jun;332:127387. S0308-8146(20)31249-8. doi: 10.1016/j.foodchem.2020.127387.Epub 2020-06-20.

ヒトサイトメガロウイルスpp65ペプチド誘導性自己抗体はTAF9タンパク質と交差反応し、BALB/cマウスでループス様自己免疫を誘導する

Human cytomegalovirus pp65 peptide-induced autoantibodies cross-reacts with TAF9 protein and induces lupus-like autoimmunity in BALB/c mice.
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第4世代のセファロスポリン耐性菌が中国上海市で分離されたSerovar Enteritidis株のうち，ハーバリングプラスミドによってもたらされたもの．

Fourth Generation Cephalosporin Resistance Among Serovar Enteritidis Isolates in Shanghai, China Conferred by Harboring Plasmids.
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  • Xuebin Xu
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  • Yihuan Wei
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  • Ming Liao
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-アセチルシステインは骨格筋の酸化ストレスを減少させ、ディスフェルリン欠損Bla/Jマウスの握力を向上させます

-Acetylcysteine Reduces Skeletal Muscles Oxidative Stress and Improves Grip Strength in Dysferlin-Deficient Bla/J Mice.
  • Paz García-Campos
  • Ximena Báez-Matus
  • Carlos Jara-Gutiérrez
  • Marilyn Paz-Araos
  • César Astorga
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  • Viviana Rodríguez
  • Jorge A Bevilacqua
  • Pablo Caviedes
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日本人原発性胆管炎患者を対象としたUrsodeoxycholic Acid Response Scoreの検証試験

A validation study of the Ursodeoxycholic Acid Response Score in Japanese patients with primary biliary cholangitis.
  • Minami Yagi
  • Kosuke Matsumoto
  • Atsumasa Komori
  • Masanori Abe
  • Naoaki Hashimoto
  • Mie Inao
  • Tadashi Namisaki
  • Kazuhito Kawata
  • Masashi Ninomiya
  • Hideki Fujii
  • Atsushi Takahashi
  • Jong-Hon Kang
  • Masaaki Takamura
  • Mie Arakawa
  • Satoru Joshita
  • Ken Sato
  • Jun Itakura
  • Takako Nomura
  • Keisuke Kakisaka
  • Akira Kaneko
  • Yamato Tamura
  • Ryo Miura
  • Mitsuhiko Aiso
  • Toshihiko Arizumi
  • Yoshinari Asaoka
  • Kentaro Kikuchi
  • Yasuhiro Takikawa
  • Tsutomu Masaki
  • Takeji Umemura
  • Akira Honda
  • Hiromasa Ohira
  • Norifumi Kawada
  • Hitoshi Yoshiji
  • Satoshi Mochida
  • Hajime Takikawa
  • Atsushi Tanaka
  • Liver Int..2020 May;doi: 10.1111/liv.14534.Epub 2020-05-21.

埋立地選択のためのMCDMベースの確率論的モデルの導入：段階的な面的拘束とマハラノビス距離の結合の導入

Introducing the coupled stepwise areal constraining and Mahalanobis distance: a promising MCDM-based probabilistic model for landfill site selection.
  • Davoud Davoudi Moghaddam
  • Ali Haghizadeh
  • Naser Tahmasebipour
  • Hossein Zeinivand
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現代生活のストレス要因に対する回復力のメカニズムを特定するためのヒトにおける回復力の縦断的決定：縦断的回復力評価（LORA）研究

Longitudinal determination of resilience in humans to identify mechanisms of resilience to modern-life stressors: the longitudinal resilience assessment (LORA) study.
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  • Eur Arch Psychiatry Clin Neurosci.2020 Jul;10.1007/s00406-020-01159-2. doi: 10.1007/s00406-020-01159-2.Epub 2020-07-18.

高脂肪高果糖食誘発ラットのインスリン抵抗性および腎障害におけるビルダグリプチンおよびスタチンによる腎炎症および小胞体ストレスの緩和

Mitigation of renal inflammation and endoplasmic reticulum stress by vildagliptin and statins in high-fat high-fructose diet-induced insulin resistance and renal injury in rats.
  • Laongdao Thongnak
  • Varanuj Chatsudthipong
  • Anusorn Lungkaphin
  • Biochim Biophys Acta Mol Cell Biol Lipids.2020 Jun;1865(9):158755. S1388-1981(20)30147-5. doi: 10.1016/j.bbalip.2020.158755.Epub 2020-06-10.

体液回収を伴う急性膵炎におけるステップアップアプローチの修正として、経皮カテーテルドレナージに先立って実施される腹部パラセントセシスドレナージの利点

Benefits of abdominal paracentesis drainage performed ahead of percutaneous catheter drainage as a modification of the step-up approach in acute pancreatitis with fluid collections.
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  • O Zerem
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パキスタンにおけるCOVID-19患者のケアに従事する医療従事者の安全意識と準備に対する多職種シミュレーションをベースとしたトレーニングの影響

Impact of multi-professional simulation-based training on the perception of safety and preparedness among health workers caring for COVID-19 patients in Pakistan.
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  • Muhammad Rizwan Bashir Kiani
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廃水をベースとした疫学は、薬物の動向を一時的に監視するためのツールとして、ローカル処方分析と組み合わせて - 英国の視点

Wastewater-based epidemiology combined with local prescription analysis as a tool for temporalmonitoring of drugs trends - A UK perspective.
  • Jack Rice
  • Andrew M Kannan
  • Erika Castrignanò
  • Kishore Jagadeesan
  • Barbara Kasprzyk-Hordern
  • Sci. Total Environ..2020 Sep;735:139433. S0048-9697(20)32950-8. doi: 10.1016/j.scitotenv.2020.139433.Epub 2020-05-15.

腎機能評価における造影CTと腎シンチグラフィの比較に関する新規数理解析の前向き研究

A prospective study of novel mathematical analysis of the contrast-enhanced computed tomography vs renal scintigraphy in renal function evaluation.
  • Dmitry Fiev
  • Alexandra Proskura
  • Sergey Khokhlachev
  • Mark Taratkin
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  • Mikhail Chernenkiy
  • Svetlana Gabdulina
  • Stephen Pax Leonard
  • Yuriy Alyaev
  • Juan Gomez Rivas
  • Dmitry Enikeev
  • Petr Glybochko
  • Eur J Radiol.2020 Jul;130:109169. S0720-048X(20)30358-2. doi: 10.1016/j.ejrad.2020.109169.Epub 2020-07-08.

COVID-19に関する不明な問題

Unclear Issues Regarding COVID-19.
  • Aycan Yuksel
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  • Canan Gunduz Gurkan
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  • Zehra Nur Toreyin
  • Feride Marim
  • Huseyin Arikan
  • Tugba Sismanlar Eyuboglu
  • Nagehan Emiralioglu
  • Irem Serifoglu
  • Elif Develi
  • Selman Celik
  • Umran Ozden Sertcelik
  • Tugba Ramasli Gursoy
  • Mehmet Fatih Elversli
  • Asli Oncel
  • Berrin Er
  • Ali Firincioglulari
  • Fatma Esra Gunaydin
  • Hilal Ozakinci
  • Neslihan Ozcelik
  • Dorina Esendagli
  • Asena Aydin
  • Neslihan Kose
  • Merve Ercelik
  • Pinar Yildiz Gulhan
  • Ethem Yildiz
  • Ilim Irmak
  • Bilge Yilmaz Kara
  • Selcuk Gurz
  • Fatma Gulsum Karakas
  • Metin Akgun
  • Eurasian J Med.2020 Jun;52(2):191-196. eajm-52-2-191. doi: 10.5152/eurasianjmed.2020.20092.

LIBRA化合物ライブラリースクリーニングキャンペーンからのトリパノソーマ・ブルセイ・プテリジン還元酵素1を標的とした2,4-ジアミノピリミジン系足場の同定

Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign.
  • Pasquale Linciano
  • Gregorio Cullia
  • Chiara Borsari
  • Matteo Santucci
  • Stefania Ferrari
  • Gesa Witt
  • Sheraz Gul
  • Maria Kuzikov
  • Bernhard Ellinger
  • Nuno Santarém
  • Anabela Cordeiro da Silva
  • Paola Conti
  • Maria Laura Bolognesi
  • Marinella Roberti
  • Federica Prati
  • Francesca Bartoccini
  • Michele Retini
  • Giovanni Piersanti
  • Andrea Cavalli
  • Luca Goldoni
  • Sine Mandrup Bertozzi
  • Fabio Bertozzi
  • Enzo Brambilla
  • Vincenzo Rizzo
  • Daniele Piomelli
  • Andrea Pinto
  • Tiziano Bandiera
  • Maria Paola Costi
  • Eur J Med Chem.2020 Mar;189:112047. S0223-5234(20)30014-3. doi: 10.1016/j.ejmech.2020.112047.Epub 2020-01-10.

ワクチンの特徴を明らかにするための新生児マウスモデルの使用および初期の生活における百日咳の高感受性および重症度を克服するための戦略

Use of a Neonatal-Mouse Model to Characterize Vaccines and Strategies for Overcoming the High Susceptibility and Severity of Pertussis in Early Life.
  • Pablo Martin Aispuro
  • Nicolás Ambrosis
  • María Eugenia Zurita
  • María Emilia Gaillard
  • Daniela Bottero
  • Daniela Flavia Hozbor
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酢酸エチル抽出物は、ファルネソイドx受容体を活性化し、酸化ストレスや炎症を抑制することで、α-ナフチルイソチオシアン酸誘発性胆汁症を緩和することが明らかになった

Ethyl acetate extract of herpetospermum pedunculosum alleviates α-naphthylisothiocyanate-induced cholestasis by activating the farnesoid x receptor and suppressing oxidative stress and inflammation in rats.
  • Xiaodong Wei
  • Xudong Fan
  • Zhiying Feng
  • Yingxiong Ma
  • Xiaozhong Lan
  • Min Chen
  • Phytomedicine.2020 Jun;76:153257. S0944-7113(20)30088-X. doi: 10.1016/j.phymed.2020.153257.Epub 2020-06-02.

NCAPGは、HER2陽性乳癌において、SRC/STAT3シグナル伝達経路の活性化を介してトラスツズマブ抵抗性を付与する

NCAPG confers trastuzumab resistance via activating SRC/STAT3 signaling pathway in HER2-positive breast cancer.
  • Lili Jiang
  • Liangliang Ren
  • Han Chen
  • Jinyuan Pan
  • Zhuojun Zhang
  • Xiangqin Kuang
  • Xuhong Chen
  • Wenhao Bao
  • Chun Lin
  • Zhongqiu Zhou
  • Danping Huang
  • Jianan Yang
  • Hongbiao Huang
  • Lan Wang
  • Ning Hou
  • Libing Song
  • Cell Death Dis.2020 Jul;11(7):547. 10.1038/s41419-020-02753-x. doi: 10.1038/s41419-020-02753-x.Epub 2020-07-18.

Brugada症候群、J波パターン心電図、ARVCで見られるテレトニン変異体は、HEK-293細胞におけるNa1.5のピーク電流を減少させることが明らかになった

Telethonin variants found in Brugada syndrome, J-wave pattern ECG, and ARVC reduce peak Na 1.5 currents in HEK-293 cells.
  • Isik Turker
  • Takeru Makiyama
  • Takeshi Ueyama
  • Akihiko Shimizu
  • Masaru Yamakawa
  • Peng-Sheng Chen
  • Matteo Vatta
  • Minoru Horie
  • Tomohiko Ai
  • Pacing Clin Electrophysiol.2020 Jun;doi: 10.1111/pace.13996.Epub 2020-06-25.

異なるマトリックス中のコカインバイオセンシングのための磁性コバルト/一本鎖抗体フラグメントで機能化されたスクリーン印刷された電極ベースのバイオセンサー

Screen printed electrode-based biosensor functionalized with magnetic cobalt/single-chain antibody fragments for cocaine biosensing in different matrices.
  • Serdar Sanli
  • Hichem Moulahoum
  • Ozge Ugurlu
  • Faezeh Ghorbanizamani
  • Zinar Pinar Gumus
  • Serap Evran
  • Hakan Coskunol
  • Suna Timur
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局所接着キナーゼの接着標的ドメイン上のLDモチーフ相互作用残基の空間配置が、ドメイン-モチーフ相互作用の親和性と特異性を決定している

Spatial arrangement of LD motif-interacting residues on focal adhesion targeting domain of Focal Adhesion Kinase determine domain-motif interaction affinity and specificity.
  • Anjali Bansal Gupta
  • Somsubhro Mukherjee
  • Catherine Quirong Pan
  • Adrian Velazquez-Campoy
  • J Sivaraman
  • Boon Chuan Low
  • Biochim Biophys Acta Gen Subj.2020 01;1864(1):129450. S0304-4165(19)30236-3. doi: 10.1016/j.bbagen.2019.129450.Epub 2019-10-30.

短期間の後肢アンローディング時の動的足刺激がラットの海馬における神経伝達の調節障害を予防することを明らかにした

Dynamic Foot Stimulations During Short-Term Hindlimb Unloading Prevent Dysregulation of the Neurotransmission in the Hippocampus of Rats.
  • Anna S Berezovskaya
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  • Svetlana D Nikolaeva
  • Alexandra A Naumova
  • Natalia S Merkulyeva
  • Boris S Shenkman
  • Margarita V Glazova
  • Cell. Mol. Neurobiol..2020 Jul;10.1007/s10571-020-00922-2. doi: 10.1007/s10571-020-00922-2.Epub 2020-07-18.

C3ORF52の機能喪失変異は、局所性常染色体劣性低毛症をもたらす

Loss-of-function variants in C3ORF52 result in localized autosomal recessive hypotrichosis.
  • Liron Malki
  • Ofer Sarig
  • Nicole Cesarato
  • Janan Mohamad
  • Talia Canter
  • Sari Assaf
  • Mor Pavlovsky
  • Dan Vodo
  • Yossi Anis
  • Ofer Bihari
  • Kiril Malovitski
  • Andrea Gat
  • Holger Thiele
  • Bethany E Perez White
  • Liat Samuelov
  • Arti Nanda
  • Amy S Paller
  • Regina C Betz
  • Eli Sprecher
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一酸化窒素は、アコニターゼ2とピルビン酸デヒドロゲナーゼを標的とすることで、M1マクロファージの代謝を再構築します

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.
  • Erika M Palmieri
  • Marieli Gonzalez-Cotto
  • Walter A Baseler
  • Luke C Davies
  • Bart Ghesquière
  • Nunziata Maio
  • Christopher M Rice
  • Tracey A Rouault
  • Teresa Cassel
  • Richard M Higashi
  • Andrew N Lane
  • Teresa W-M Fan
  • David A Wink
  • Daniel W McVicar
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小児急性白血病におけるT細胞上の免疫チェックポイント受容体とそのリガンドの白血病芽球上での発現

Expression of Immune Checkpoint Receptors on T-Cells and Their Ligands on Leukemia Blasts in Childhood Acute Leukemia.
  • Sung Han Kang
  • Hyun Ju Hwang
  • Jae Won Yoo
  • Hyery Kim
  • Eun Seok Choi
  • Sang-Hyun Hwang
  • Young-Uk Cho
  • Seongsoo Jang
  • Chan-Jeoung Park
  • Ho Joon Im
  • Jong Jin Seo
  • Nayoung Kim
  • Kyung-Nam Koh
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魚類メラノコルチン-4受容体（MC4R）における偏ったシグナル伝達。魚類のメラノコルチン-4受容体（MC4R）における偏ったシグナル伝達：魚類のメラノコルチン-4受容体（MC4R）における偏ったシグナル伝達：魚類のメラノコルチン-4受容体（MC4R）における偏ったシグナル伝達：魚類のメラノコルチン-4受容体（MC4R）における偏ったシグナル伝達：魚類のメラノコルチン-4受容体（MC4R）における偏ったシグナル伝達：魚類のメラノコルチン-4受容体（MC4R）における偏ったシグナル伝達：魚類のメラノコルチン-4受容体（MC4R）における偏ったシグナル伝達

Biased signaling in fish melanocortin-4 receptors (MC4Rs): Divergent pharmacology of four ligands on spotted scat (Scatophagus argus) and grass carp (Ctenopharyngodon idella) MC4Rs.
  • Zhao Yang
  • Xu-Fang Liang
  • Guang-Li Li
  • Ya-Xiong Tao
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カンナビジオール濃縮エキスは、ラフォーラ病の動物モデルにおける認知障害を減少させたが、てんかん発作を減少させなかった

Cannabidiol-Enriched Extract Reduced the Cognitive Impairment but Not the Epileptic Seizures in a Lafora Disease Animal Model.
  • Ester Aso
  • Pol Andrés-Benito
  • Jordi Grau-Escolano
  • Laura Caltana
  • Alicia Brusco
  • Pascual Sanz
  • Isidre Ferrer
  • Cannabis Cannabinoid Res.2020 Jun;5(2):150-163. 10.1089/can.2019.0005. doi: 10.1089/can.2019.0005.Epub 2020-06-05.

ブラジル南東部グアナバラ湾のマングローブにおける油流出後の魚類、フジツボ、カニ類における多環芳香族炭化水素濃度の変化と変動

Changes and variations of polycyclic aromatic hydrocarbon concentrations in fish, barnacles and crabs following an oil spill in a mangrove of Guanabara Bay, Southeast Brazil.
  • Abílio Soares-Gomes
  • Roberta L Neves
  • Ricardo Aucélio
  • Paulo H Van Der Ven
  • Fábio B Pitombo
  • Carla L T Mendes
  • Roberta L Ziolli
  • Mar. Pollut. Bull..2010 Aug;60(8):1359-63. S0025-326X(10)00214-6. doi: 10.1016/j.marpolbul.2010.05.013.Epub 2010-06-09.

硫黄マスタード眼被曝者の涙と血清インターロイキン-8と血清CX3CL1、CCL2、CCL5

Tear and serum interleukin-8 and serum CX3CL1, CCL2 and CCL5 in sulfur mustard eye-exposed patients.
  • Tooba Ghazanfari
  • Hassan Ghasemi
  • Roya Yaraee
  • Mahmoud Mahmoudi
  • Mohammad Ali Javadi
  • Mohammad Reza Soroush
  • Soghrat Faghihzadeh
  • Ali Mohammad Mohseni Majd
  • Raheleh Shakeri
  • Mahmoud Babaei
  • Fatemeh Heidary
  • Zuhair Mohammad Hassan
  • Int. Immunopharmacol..2019 Dec;77:105844. S1567-5769(19)31082-3. doi: 10.1016/j.intimp.2019.105844.Epub 2019-10-24.

UVA及び可視光照射下での有機微量汚染物質の光電子フェントン処理における鉄系二次元MOFの機構と安定性

Mechanism and stability of an Fe-based 2D MOF during the photoelectro-Fenton treatment of organic micropollutants under UVA and visible light irradiation.
  • Zhihong Ye
  • Giulia E M Schukraft
  • Anouk L'Hermitte
  • Ying Xiong
  • Enric Brillas
  • Camille Petit
  • Ignasi Sirés
  • Water Res..2020 Jul;184:115986. S0043-1354(20)30523-6. doi: 10.1016/j.watres.2020.115986.Epub 2020-07-10.

チリの公衆衛生システムにおける AL アミロイドーシス：保留された負債。チリのモノクローナル・ガンモパチー協同組合グループの多施設研究

AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group.
  • Camila Peña
  • José Tomás González
  • Hernán López-Vidal
  • Javiera Donoso
  • Carolina Contreras
  • Carmen Gloria Vergara
  • Ricardo Hojas
  • Pablo Soto
  • Gonzalo Correa
  • Ricardo Valjalo
  • Álvaro Ríos
  • Jorge Larrondo
  • Jaime Álvarez
  • Christine Rojas
  • Rev Med Chil.2019 Oct;147(10):1239-1246. S0034-98872019001001239. doi: 10.4067/s0034-98872019001001239.

潰瘍性大腸炎に対する補完療法と代替療法の有効性と安全性の比較。システマティックレビューとメタアナリシスのためのプロトコル

A comparison of the efficacy and safety of complementary and alternative therapies for ulcerative colitis: A protocol for systematic review and meta-analysis.
  • Meiqi Lu
  • Ting Zhang
  • Zhen Lu
  • Wei Wang
  • Ting Chen
  • Zhiqun Cao
  • Medicine (Baltimore).2020 Jul;99(28):e21219. 00005792-202007100-00124. doi: 10.1097/MD.0000000000021219.

切除した胃癌において、腫瘍浸潤性CD8+ T細胞と腫瘍関連CD68+マクロファージの組み合わせは、術後の予後と術後補助化学療法の有益性を予測する

Tumor-infiltrating CD8+ T cells combined with tumor-associated CD68+ macrophages predict postoperative prognosis and adjuvant chemotherapy benefit in resected gastric cancer.
  • Jun Lu
  • Yu Xu
  • Yuan Wu
  • Xiao-Yan Huang
  • Jian-Wei Xie
  • Jia-Bin Wang
  • Jian-Xian Lin
  • Ping Li
  • Chao-Hui Zheng
  • Ai-Min Huang
  • Chang-Ming Huang
  • BMC Cancer.2019 Sep;19(1):920. 10.1186/s12885-019-6089-z. doi: 10.1186/s12885-019-6089-z.Epub 2019-09-14.

ヴァインベルク経路最適化のための実験とモデリングを組み合わせたアプローチ

A combined experimental and modelling approach for the Weimberg pathway optimisation.
  • Lu Shen
  • Martha Kohlhaas
  • Junichi Enoki
  • Roland Meier
  • Bernhard Schönenberger
  • Roland Wohlgemuth
  • Robert Kourist
  • Felix Niemeyer
  • David van Niekerk
  • Christopher Bräsen
  • Jochen Niemeyer
  • Jacky Snoep
  • Bettina Siebers
  • Nat Commun.2020 02;11(1):1098. 10.1038/s41467-020-14830-y. doi: 10.1038/s41467-020-14830-y.Epub 2020-02-27.

ゼブラフィッシュにおけるリゾホスファチジン酸受容体3(LPAR3)遺伝子の不安、概日リズム運動、短期記憶の調節に関わる新規機能を明らかにした

A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory.
  • Yu-Nung Lin
  • Gilbert Audira
  • Nemi Malhotra
  • Nguyen Thi Ngoc Anh
  • Petrus Siregar
  • Jen-Her Lu
  • Hsinyu Lee
  • Chung-Der Hsiao
  • Int J Mol Sci.2020 Apr;21(8). E2837. doi: 10.3390/ijms21082837.Epub 2020-04-18.

プロバイオティクス特性を有するラクトバチルス・ガセリ JM1 は PI3K/Akt シグナル伝達経路を活性化することで炎症反応を緩和する可能性がある

Lactobacillus gasseri JM1 with potential probiotic characteristics alleviates inflammatory response by activating the PI3K/Akt signaling pathway in vitro.
  • Linlin Sun
  • Wenli Tian
  • Xiaojie Guo
  • Yu Zhang
  • Xinyu Liu
  • Xuesong Li
  • Yazhen Tian
  • Chaoxin Man
  • Yujun Jiang
  • J. Dairy Sci..2020 Jun;S0022-0302(20)30481-1. doi: 10.3168/jds.2020-18187.Epub 2020-06-26.

アレルギー性鼻炎の治療における経鼻コルチコステロイドへの付加療法としては、経鼻H1-抗ヒスタミンが経口H1-抗ヒスタミンよりも優れています

Intranasal antihistamine is superior to oral H1-antihistamine as an add-on therapy to intranasal corticosteroid for treating allergic rhinitis.
  • Kun Du
  • Hui Qing
  • Ming Zheng
  • Xiangdong Wang
  • Luo Zhang
  • Ann. Allergy Asthma Immunol..2020 Jul;S1081-1206(20)30446-4. doi: 10.1016/j.anai.2020.06.038.Epub 2020-07-07.

硫黄-マスタード暴露後の長期重症眼障害者における免疫グロブリンの血清レベルの変化

Alteration in serum levels of immunoglobulins in seriously eye-injured long-term following sulfur-mustard exposure.
  • Tooba Ghazanfari
  • Ali Mostafaie
  • Farideh Talebi
  • Mohammad Reza Vaez Mahdavi
  • Mohammad Ebrahim Yarmohammadi
  • Nayere Askari
  • Sakine Moaiedmohseni
  • Ali Mohammad Mohseni Majd
  • Ensie Sadat Mirsharif
  • Zeinab Ghazanfari
  • Zuhair Mohammad Hassan
  • Jalaledin Shams
  • Davoud Jamali
  • Soghrat Faghihzadeh
  • Int. Immunopharmacol..2020 Mar;80:105895. S1567-5769(19)31696-0. doi: 10.1016/j.intimp.2019.105895.Epub 2019-11-29.

無細胞DNAスクリーニングと複合スクリーニングに基づく妊娠期初のスクリーニング：女性の経験に関するランダム化臨床試験

First-trimester screening based on cell-free DNA vs combined screening: a randomized clinical trial on women's experience.
  • Sonia Migliorini
  • Gabriele Saccone
  • Fiora Silvestro
  • Giulia Massaro
  • Bruno Arduino
  • Pietro D'Alessandro
  • Maria Teresa Petti
  • Jessica Anna Cinzia Paino
  • Maurizio Guida
  • Mariavittoria Locci
  • Fulvio Zullo
  • Prenat. Diagn..2020 Jul;doi: 10.1002/pd.5800.Epub 2020-07-19.

臨床疫学的プロファイルと最小残存病変によって予測されるアウトカム インドの第三次がん研究所でMixed-phenotype Acute Leukemia with Children With Mixed-phenotype Modified MCP-841 Protocolで治療された小児の臨床疫学的プロファイルとアウトカム

Clinicoepidemiological Profile and Outcome Predicted by Minimal Residual Disease in Children With Mixed-phenotype Acute Leukemia Treated on a Modified MCP-841 Protocol at a Tertiary Cancer Institute in India.
  • Htar H Myint
  • Sneha Tandon
  • Gaurav Narula
  • Maya Prasad
  • Papagudi Subramanian
  • Nikhil Patkar
  • Prashant Tembhare
  • Sumeet Gujral
  • Shripad Banavali
  • J. Pediatr. Hematol. Oncol..2020 Jun;doi: 10.1097/MPH.0000000000001880.Epub 2020-06-26.

右心室機能における非縦方向運動成分の重要性。健康なボランティアを対象とした三次元心エコー検査

Importance of Nonlongitudinal Motion Components in Right Ventricular Function: Three-Dimensional Echocardiographic Study in Healthy Volunteers.
  • Bálint Károly Lakatos
  • Yosuke Nabeshima
  • Márton Tokodi
  • Yasufumi Nagata
  • Zoltán Tősér
  • Kyoko Otani
  • Tetsuji Kitano
  • Alexandra Fábián
  • Adrienn Ujvári
  • András Mihály Boros
  • Béla Merkely
  • Attila Kovács
  • Masaaki Takeuchi
  • J Am Soc Echocardiogr.2020 Jun;S0894-7317(20)30211-X. doi: 10.1016/j.echo.2020.04.002.Epub 2020-06-30.

マクロファージの活性化におけるリーシュマニア・ブラジリエンシスのプロマスティゴートとアマスティゴートからの脂質の関与

Involvement of lipids from Leishmania braziliensis promastigotes and amastigotes in macrophage activation.
  • Ivanna Emilce Carfagna
  • Federico Nicolás Penas
  • Emanuel Bott
  • Estela María Lammel
  • Nora Beatriz Goren
  • María Laura Belaunzarán
  • Guadalupe Gimenez
  • Mol. Immunol..2020 Jul;125:104-114. S0161-5890(20)30401-6. doi: 10.1016/j.molimm.2020.06.023.Epub 2020-07-10.

アルツハイマー病におけるリゾリン脂質とそのG共役型蛋白質シグナル伝達.アルツハイマー病におけるリソリン脂質とそのG共役型タンパク質シグナル伝達：生理機能から病理学的障害まで

Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer's Disease: From Physiological Performance to Pathological Impairment.
  • Yining Hao
  • Min Guo
  • Yiwei Feng
  • Qiang Dong
  • Mei Cui
  • Front Mol Neurosci.2020;13:58. doi: 10.3389/fnmol.2020.00058.Epub 2020-04-15.

グリーンミセル電気泳動クロマトグラフィー法の段階的な最適化と感度の向上により、様々な二元系の点眼剤に含まれるフルオロキノロン類とグルココルチコイド類を同時に測定することができました

Stepwise optimization and sensitivity improvement of green micellar electrokinetic chromatography method to simultaneously determine some fluoroquinolones and glucocorticoids present in various binary ophthalmic formulations.
  • Hebatallah M Essam
  • Martin N Saad
  • Eman S Elzanfaly
  • Sawsan M Amer
  • Biomed. Chromatogr..2020 Jul;:e4941. doi: 10.1002/bmc.4941.Epub 2020-07-06.

アマゾンで人間の毒殺に関与している最も重要なヘビである。蛇の生物学と臨床毒物学の知識の発展にベノミクスがどのように貢献しているか

, the most important snake involved in human envenomings in the amazon: How venomics contributes to the knowledge of snake biology and clinical toxinology.
  • Wuelton Marcelo Monteiro
  • Jorge Carlos Contreras-Bernal
  • Pedro Ferreira Bisneto
  • Jacqueline Sachett
  • Iran Mendonça da Silva
  • Marcus Lacerda
  • Allyson Guimarães da Costa
  • Fernando Val
  • Lisele Brasileiro
  • Marco Aurélio Sartim
  • Sâmella Silva-de-Oliveira
  • Paulo Sérgio Bernarde
  • Igor L Kaefer
  • Felipe Gobbi Grazziotin
  • Fan Hui Wen
  • Ana Maria Moura-da-Silva
  • Toxicon X.2020 Jun;6:100037. S2590-1710(20)30015-1. doi: 10.1016/j.toxcx.2020.100037.Epub 2020-04-23.

鈴木カップリング反応に向けて触媒活性を向上させたPd@グラフェンナノコンポジットの簡便合成

Facile synthesis of Pd@graphene nanocomposites with enhanced catalytic activity towards Suzuki coupling reaction.
  • Mujeeb Khan
  • Mohammed Rafi Shaik
  • Syed Farooq Adil
  • Mufsir Kuniyil
  • Muhammad Ashraf
  • Hajo Frerichs
  • Massih Ahmad Sarif
  • Mohammed Rafiq H Siddiqui
  • Abdulrahman Al-Warthan
  • Joselito P Labis
  • Mohammad Shahidul Islam
  • Wolfgang Tremel
  • Muhammad Nawaz Tahir
  • Sci Rep.2020 Jul;10(1):11728. 10.1038/s41598-020-68124-w. doi: 10.1038/s41598-020-68124-w.Epub 2020-07-16.

Metro Detroit における Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Infections の臨床疫学と分子疫学。ST-131クローンの初期優勢

Clinical and Molecular Epidemiology of Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Infections in Metro Detroit: Early Dominance of the ST-131 Clone.
  • John P Mills
  • Keith S Kaye
  • Richard Evans
  • Elizabeth Salzman
  • Jason Pogue
  • Kayoko Hayakawa
  • Dror Marchaim
  • Pansy Awasthy
  • Madiha Salim
  • Emily T Martin
  • Infect Dis Ther.2020 Jul;10.1007/s40121-020-00321-6. doi: 10.1007/s40121-020-00321-6.Epub 2020-07-18.

Rhizoglomus irregulareとハイパー付着リン酸塩可溶化菌との相互作用により、ソラナムリコペルシカムの植物バイオマスが増加することが明らかになった

The interaction between Rhizoglomus irregulare and hyphae attached phosphate solubilizing bacteria increases plant biomass of Solanum lycopersicum.
  • Shubhangi Sharma
  • Stéphane Compant
  • Max-Bernhard Ballhausen
  • Silke Ruppel
  • Philipp Franken
  • Microbiol. Res..2020 Jul;240:126556. S0944-5013(20)30424-9. doi: 10.1016/j.micres.2020.126556.Epub 2020-07-09.

生および食塩加工された Achyranthes bidentata は、エストロゲン様経路を介して活性酸素とアポトーシスを阻害することで、LPS誘発性の急性腎障害を減衰させます

Raw and salt-processed Achyranthes bidentata attenuate LPS-induced acute kidney injury by inhibiting ROS and apoptosis via an estrogen-like pathway.
  • Shengchao Wang
  • Mengnan Zeng
  • Benke Li
  • Yuxuan Kan
  • Beibei Zhang
  • Xiaoke Zheng
  • Weisheng Feng
  • Biomed. Pharmacother..2020 Jun;129:110403. S0753-3322(20)30596-5. doi: 10.1016/j.biopha.2020.110403.Epub 2020-06-20.

ヒトにおける重症SARS-CoV-2感染は、血清リピドームの変化により、エイコサノイド免疫メディエーターの調節障害が生じることで定義される

Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators.
  • Benjamin Schwarz
  • Lokesh Sharma
  • Lydia Roberts
  • Xiaohua Peng
  • Santos Bermejo
  • Ian Leighton
  • Arnau Casanovas Massana
  • Shelli Farhadian
  • Albert Ko
  • Charles DelaCruz
  • Catharine M Bosio
  • medRxiv.2020 Jul;2020.07.09.20149849. doi: 10.1101/2020.07.09.20149849.Epub 2020-07-13.

新奇なMED12変異が症候性冠動脈性心疾患に与える影響は？2人の男性兄弟の症例報告の分析

What is the impact of a novel MED12 variant on syndromic conotruncal heart defects? Analysis of case report on two male sibs.
  • Silvia Amodeo
  • Giuseppe Vitrano
  • Melania Guardino
  • Giuseppe Paci
  • Fulvio Corselli
  • Vincenzo Antona
  • Giuseppe Barrano
  • Monia Magliozzi
  • Antonio Novelli
  • Renato Venezia
  • Giovanni Corsello
  • Ital J Pediatr.2020 Jul;46(1):98. 10.1186/s13052-020-00865-w. doi: 10.1186/s13052-020-00865-w.Epub 2020-07-18.

Tc-99m ECD脳単光子放出コンピューター断層撮影（SPECT）は，ビデオ脳波所見とMRI所見が不一致の症例において，てんかん原性領域の局在化と術後の発作自由度の予測において増分的な価値があるか？

Does Tc-99m ECD ictal brain SPECT have incremental value in localization of epileptogenic zone and predicting postoperative seizure freedom in cases with discordant video electroencephalogram and MRI findings?
  • Shwetal Uday Pawar
  • Sangeeta Hasmukh Ravat
  • Dattatraya Prakash Muzumdar
  • Shilpa Sushilkumar Sankhe
  • Akash Harakchand Chheda
  • Ashmi Shyam Manglunia
  • Arnaaz Noormohamed Maldar
  • Nucl Med Commun.2020 Jun;doi: 10.1097/MNM.0000000000001240.Epub 2020-06-23.

シヌラリオリドは、EMTプロセスのダウンレギュレーションとFAK/PI3K/AKT/mTORおよびMAPKsシグナル伝達経路の抑制を介して胃癌細胞の移行と浸潤を抑制する

Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways.
  • Yu-Jen Wu
  • Shih-Hsiung Lin
  • Zhong-Hao Din
  • Jui-Hsin Su
  • Chih-I Liu
  • Mar Drugs.2019 Nov;17(12). E668. doi: 10.3390/md17120668.Epub 2019-11-27.

触媒ベースの分解の全体的評価のための性能指標-厳選された医薬品およびパーソナルケア製品（PPCPs）のケーススタディ

Performance indicators for a holistic evaluation of catalyst-based degradation-A case study of selected pharmaceuticals and personal care products (PPCPs).
  • Mingjing He
  • Zhonghao Wan
  • Daniel C W Tsang
  • Yuqing Sun
  • Eakalak Khan
  • Deyi Hou
  • Nigel J D Graham
  • J. Hazard. Mater..2020 Jul;402:123460. S0304-3894(20)31449-7. doi: 10.1016/j.jhazmat.2020.123460.Epub 2020-07-12.

地中海底引き網漁業における春と夏の商業的に重要な4種のコデンドサイズ選択性の予測モデル。コーデンドの種類と漁獲サイズの効果

Predictive models for codend size selectivity for four commercially important species in the Mediterranean bottom trawl fishery in spring and summer: Effects of codend type and catch size.
  • Jure Brčić
  • Bent Herrmann
  • Antonello Sala
  • PLoS ONE.2018;13(10):e0206044. PONE-D-18-05407. doi: 10.1371/journal.pone.0206044.Epub 2018-10-22.

正準的および非正準的なＷｎｔシグナル伝達は、結腸癌細胞においてＷｎｔによって同時に活性化される

Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells.
  • Eric Flores-Hernández
  • Dora M Velázquez
  • M Cristina Castañeda-Patlán
  • Gabriela Fuentes-García
  • Gabriela Fonseca-Camarillo
  • Jesús K Yamamoto-Furusho
  • M Teresa Romero-Avila
  • J Adolfo García-Sáinz
  • Martha Robles-Flores
  • Cell. Signal..2020 Aug;72:109636. S0898-6568(20)30113-3. doi: 10.1016/j.cellsig.2020.109636.Epub 2020-04-10.

ラジウムと安定同位体（重水素と酸素-18）を用いたポヤン湖（中国東部）への地下水の流出場所と流出源の特定

Identifying locations and sources of groundwater discharge into Poyang Lake (eastern China) using radium and stable isotopes (deuterium and oxygen-18).
  • Fu Liao
  • Guangcai Wang
  • Lixin Yi
  • Zheming Shi
  • Guoqiang Cheng
  • Qingmin Kong
  • Wenqing Mu
  • Liang Guo
  • Ke Cheng
  • Na Dong
  • Chenglong Liu
  • Sci. Total Environ..2020 Jun;740:140163. S0048-9697(20)33684-6. doi: 10.1016/j.scitotenv.2020.140163.Epub 2020-06-12.

デュアルロイシンジッパーキナーゼはマウスの成体脳で定常的に活性化しており、ストレス誘発機能と恒常性機能の両方を持っている

Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions.
  • Sunil Goodwani
  • Celia Fernandez
  • Paul J Acton
  • Virginie Buggia-Prevot
  • Morgan L McReynolds
  • Jiacheng Ma
  • Cheng Hui Hu
  • Mary E Hamby
  • Yongying Jiang
  • Kang Le
  • Michael J Soth
  • Philip Jones
  • William J Ray
  • Int J Mol Sci.2020 Jul;21(14). E4849. doi: 10.3390/ijms21144849.Epub 2020-07-09.

HLA-DR+メモリーT細胞における遺伝的に無傷なHIVの高レベルは、リザーバー研究に有用であることを示している

High levels of genetically intact HIV in HLA-DR+ memory T cells indicates their value for reservoir studies.
  • Bethany A Horsburgh
  • Eunok Lee
  • Bonnie Hiener
  • John-Sebastian Eden
  • Timothy E Schlub
  • Susanne von Stockenstrom
  • Lina Odevall
  • Jeffrey M Milush
  • Teri Liegler
  • Elizabeth Sinclair
  • Rebecca Hoh
  • Eli A Boritz
  • Daniel C Douek
  • Remi Fromentin
  • Nicolas Chomont
  • Steven G Deeks
  • Frederick M Hecht
  • Sarah Palmer
  • AIDS.2020 04;34(5):659-668. doi: 10.1097/QAD.0000000000002465.

Surveillance, epidemiology, and end results (SEER)データベースにおける手術を受けた非小細胞肺癌（NSCLC）患者の死亡率を予測するためのノモグラムモデル

A nomogram model to predict death rate among non-small cell lung cancer (NSCLC) patients with surgery in surveillance, epidemiology, and end results (SEER) database.
  • Bo Jia
  • Qiwen Zheng
  • Jingjing Wang
  • Hongyan Sun
  • Jun Zhao
  • Meina Wu
  • Tongtong An
  • Yuyan Wang
  • Minglei Zhuo
  • Jianjie Li
  • Xue Yang
  • Jia Zhong
  • Hanxiao Chen
  • Yujia Chi
  • Xiaoyu Zhai
  • Ziping Wang
  • BMC Cancer.2020 Jul;20(1):666. 10.1186/s12885-020-07147-y. doi: 10.1186/s12885-020-07147-y.Epub 2020-07-17.

大頭症、知的障害、睡眠時無呼吸の患者におけるde novo ZBTB7A変異：19p13.3マイクロ欠失における表現型発達の意味合い

De novo ZBTB7A variant in a patient with macrocephaly, intellectual disability, and sleep apnea: implications for the phenotypic development in 19p13.3 microdeletions.
  • Akira Ohishi
  • Yohei Masunaga
  • Shigeo Iijima
  • Kaori Yamoto
  • Fumiko Kato
  • Maki Fukami
  • Hirotomo Saitsu
  • Tsutomu Ogata
  • J. Hum. Genet..2020 Jan;65(2):181-186. 10.1038/s10038-019-0690-5. doi: 10.1038/s10038-019-0690-5.Epub 2019-10-23.

リポソームカプセル化した2,4,6-トリヒドロキシゲラニルアセトフェノンのラットにおける薬物動態と代謝

Pharmacokinetics and Metabolism of Liposome-Encapsulated 2,4,6-Trihydroxygeranylacetophenone in Rats Using High-Resolution Orbitrap Liquid Chromatography Mass Spectrometry.
  • Yamen Alkhateeb
  • Qais Bashir Jarrar
  • Faridah Abas
  • Yaya Rukayadi
  • Chau Ling Tham
  • Yuen Kah Hay
  • Khozirah Shaari
  • Molecules.2020 Jul;25(13). E3069. doi: 10.3390/molecules25133069.Epub 2020-07-06.

ネパールのテライ・ハイウェイ地区のMSMおよびトランスジェンダー女性におけるHIV、梅毒の有病率、性的リスク行動の社会的・構造的決定要因と医療サービス利用の評価：回答者主導サンプリングを用いた生物学的・行動学的統合サーベイランス調査に基づく調査結果

Prevalence of HIV, syphilis, and assessment of the social and structural determinants of sexual risk behaviour and health service utilisation among MSM and transgender women in Terai highway districts of Nepal: findings based on an integrated biological and behavioural surveillance survey using respondent driven sampling.
  • Margrethe Storm
  • Keshab Deuba
  • Jose Damas
  • Upendra Shrestha
  • Bir Rawal
  • Rajan Bhattarai
  • Gaetano Marrone
  • BMC Infect. Dis..2020 Jun;20(1):402. 10.1186/s12879-020-05122-3. doi: 10.1186/s12879-020-05122-3.Epub 2020-06-08.

Kv3.1/Kv3.2の変調は、in vitroのADマウスモデルにおいて、Aβによって誘発された高速スパイク性介在ニューロンの発火の非同期化を救済することにより、ガンマ振動を促進する

Modulation of Kv3.1/Kv3.2 promotes gamma oscillations by rescuing Aβ-induced desynchronization of fast-spiking interneuron firing in an AD mouse model in vitro.
  • Yuniesky Andrade-Talavera
  • Luis Enrique Arroyo-García
  • Gefei Chen
  • Jan Johansson
  • André Fisahn
  • J. Physiol. (Lond.).2020 Jul;doi: 10.1113/JP279718.Epub 2020-07-07.

アルジェリアのブドウ畑の土壌に生息する放線菌．アルジェリアのブドウ畑土壌に生息する放線菌の分類，ブドウ幹病菌に対する抗真菌力，植物の生育を促進する特徴．

Actinobacteria Associated with Vineyard Soils of Algeria: Classification, Antifungal Potential Against Grapevine Trunk Pathogens and Plant Growth-Promoting Features.
  • Affaf Laassami
  • Amine Yekkour
  • Atika Meklat
  • Nadjette Djemouai
  • Abdelghani Zitouni
  • Salim Mokrane
  • Pascal Lecomte
  • Patrice Rey
  • Akila Berraf-Tebbal
  • Curr. Microbiol..2020 Jun;10.1007/s00284-020-02097-x. doi: 10.1007/s00284-020-02097-x.Epub 2020-06-27.

ラットに脂肪由来間質細胞を自家移植し、低換気を併用することで、リポ多糖類誘発性急性肺障害に対する防御能が向上した

Enhanced protection against lipopolysaccharide-induced acute lung injury by autologous transplantation of adipose-derived stromal cells combined with low tidal volume ventilation in rats.
  • Zuodi Liang
  • Xiuru Yin
  • Wenchong Sun
  • Shuo Zhang
  • Xiaohuan Chen
  • Ling Pei
  • Ning Zhao
  • J. Cell. Physiol..2020 Jul;doi: 10.1002/jcp.29936.Epub 2020-07-13.

コンセンサス・ステートメント。COVID-19パンデミックの文脈における耳鼻咽喉科におけるコルチコステロイド治療

Consensus statement. Corticosteroid therapy in ENT in the context of the COVID-19 pandemic.
  • P Herman
  • C Vincent
  • C Parietti Winkler
  • N Loundon
  • V Couloigner
  • F Tankere
  • S Tringali
  • P Gallet
  • J-F Papon
  • M Montava
  • J-P Lavieille
  • A Charpiot
  • S Schmerber
  • Eur Ann Otorhinolaryngol Head Neck Dis.2020 May;S1879-7296(20)30104-6. doi: 10.1016/j.anorl.2020.04.014.Epub 2020-05-04.

Pfr-favoured Variantsの検索におけるフィトクロム光化学の迅速なスクリーニングと特性評価のための分光学に基づく方法論

A Spectroscopy-based Methodology for Rapid Screening and Characterization of Phytochrome Photochemistry in Search of Pfr-favoured Variants.
  • Giuliano Tomás Antelo
  • Maximiliano Sánchez-Lamas
  • Fernando Alberto Goldbaum
  • Lisandro Horacio Otero
  • Hernán Ruy Bonomi
  • Jimena Rinaldi
  • Photochem. Photobiol..2020 Jul;doi: 10.1111/php.13313.Epub 2020-07-19.

Leu124Serfs*26、早期の心血管系合併症を伴う先天性全般化リポジストロフィーの新規変異

Leu124Serfs*26, a novel mutation in congenital generalized lipodystrophy with early cardiovascular complications.
  • Renan Magalhães Montenegro Junior
  • Grayce Ellen da Cruz Paiva Lima
  • Virgínia Oliveira Fernandes
  • Ana Paula Dias Rangel Montenegro
  • Clarisse Mourão Melo Ponte
  • Lívia Vasconcelos Martins
  • Daniel Pascoalino Pinheiro
  • Maria Elisabete Amaral de Moraes
  • Manoel Odorico de Moraes Filho
  • Catarina Brasil d'Alva
  • Diabetol Metab Syndr.2020;12:28. 538. doi: 10.1186/s13098-020-00538-y.Epub 2020-04-06.

Cys328でのビメンチンS-グルタチオン化はフィラメントの伸長を阻害し、成熟フィラメントの切断を誘導する

Vimentin S-glutathionylation at Cys328 inhibits filament elongation and induces severing of mature filaments in vitro.
  • Magdalena Kaus-Drobek
  • Norbert Mücke
  • Roman H Szczepanowski
  • Tatjana Wedig
  • Mariusz Czarnocki-Cieciura
  • Magdalena Polakowska
  • Harald Herrmann
  • Aleksandra Wysłouch-Cieszyńska
  • Michał Dadlez
  • FEBS J..2020 Apr;doi: 10.1111/febs.15321.Epub 2020-04-07.

関節リウマチおよび関連する併存疾患を有する患者のケアの質を向上させるための検討

Considerations for improving quality of care of patients with rheumatoid arthritis and associated comorbidities.
  • Tore K Kvien
  • Alejandro Balsa
  • Neil Betteridge
  • Maya H Buch
  • Patrick Durez
  • Ennio Giulio Favalli
  • Guillaume Favier
  • Cem Gabay
  • Rinie Geenen
  • Ioanna Gouni-Berthold
  • Frank van den Hoogen
  • Alison Kent
  • Lars Klareskog
  • Mikkel Ostergaard
  • Karel Pavelka
  • Joaquim Polido Pereira
  • Anne Grete Semb
  • Magnus Sköld
  • Maxime Dougados
  • RMD Open.2020 Jul;6(2). e001211. doi: 10.1136/rmdopen-2020-001211.

ラットにおけるジモサン誘発性側頭顎関節炎に対する抽出物の保護効果

Protective effect of extract on the zymosan-induced temporomandibular joint arthritis in rats.
  • Danielle Rocha do Val
  • Mirna Marques Bezerra
  • Francisco Isaac Fernandes Gomes
  • Christiane Aguiar Nobre
  • Suzana Capistrano Teixeira
  • Jonas Cavalcante Lemos
  • Karuza Maria Alves Pereira
  • Vicente de Paulo Teixeira Pinto
  • Antônio Alfredo Rodrigues E Silva
  • Eryvelton de Sousa Franco
  • Maria Bernadete de Sousa Maia
  • Hellíada Vasconcelos Chaves
  • J Oral Biol Craniofac Res.2020 Jul-Sep;10(3):276-280. S2212-4268(20)30067-1. doi: 10.1016/j.jobcr.2020.05.005.Epub 2020-05-28.

腸内細菌科のカルバペネマーゼ産生菌のメロペネム依存性殺傷を増強するニューデリーメタロ-β-ラクタマーゼ-1阻害ペプチドの発見と特徴付け

Discovery and characterization of New Delhi metallo-β-lactamase-1 inhibitor peptides that potentiate meropenem-dependent killing of carbapenemase-producing Enterobacteriaceae.
  • Misha I Kazi
  • Blair W Perry
  • Daren C Card
  • Richard D Schargel
  • Hana B Ali
  • Victor C Obuekwe
  • Madhab Sapkota
  • Katie N Kang
  • Mark W Pellegrino
  • David E Greenberg
  • Todd A Castoe
  • Joseph M Boll
  • J. Antimicrob. Chemother..2020 Jun;dkaa242. doi: 10.1093/jac/dkaa242.Epub 2020-06-26.

大規模肝切除術前の放射線学的同時肝動脈静脈塞栓術（RASPE）。門脈塞栓療法と比較して肝肥大を最適化するための優れた方法

Radiological Simultaneous Portohepatic Vein Embolization (RASPE) Before Major Hepatectomy: A Better Way to Optimize Liver Hypertrophy Compared to Portal Vein Embolization.
  • Christophe Laurent
  • Benjamin Fernandez
  • Arthur Marichez
  • Jean-Philippe Adam
  • Panteleimon Papadopoulos
  • Bruno Lapuyade
  • Laurence Chiche
  • Ann. Surg..2020 Aug;272(2):199-205. 00000658-202008000-00001. doi: 10.1097/SLA.0000000000003905.

抗凝固患者におけるループス抗凝固剤の検出．国際血栓症・止血学会のループス抗凝固剤/抗リン脂質抗体の科学的・標準化委員会からのガイダンス

Lupus anticoagulant detection in anticoagulated patients. Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis.
  • Armando Tripodi
  • Hannah Cohen
  • Katrien M J Devreese
  • J. Thromb. Haemost..2020 Jul;18(7):1569-1575. doi: 10.1111/jth.14846.

BEAS-2B気管支気道上皮細胞におけるSMPD1活性の低下は、NRF2活性、サイトカイン合成、好中球リクルートの増加をもたらす

Decreasing SMPD1 activity in BEAS-2B bronchial airway epithelial cells results in increased NRF2 activity, cytokine synthesis and neutrophil recruitment.
  • Elyse MacFadden-Murphy
  • Lucie Roussel
  • Guy Martel
  • Julie Bérubé
  • Simon Rousseau
  • Biochem. Biophys. Res. Commun..2017 Jan;482(4):645-650. S0006-291X(16)31950-7. doi: 10.1016/j.bbrc.2016.11.087.Epub 2016-11-16.

救急部患者のアルコール乱用を減らすためのテキストメッセージベースの介入の実行可能性と受容性。コントロールされた概念実証試験

Feasibility and Acceptability of a Text Message-Based Intervention to Reduce Overuse of Alcohol in Emergency Department Patients: Controlled Proof-of-Concept Trial.
  • Elizabeth Burner
  • Mark Zhang
  • Sophie Terp
  • Kelsey Ford Bench
  • Joshua Lee
  • Chun Nok Lam
  • Jesus R Torres
  • Michael Menchine
  • Sanjay Arora
  • JMIR Mhealth Uhealth.2020 Jun;8(6):e17557. v8i6e17557. doi: 10.2196/17557.Epub 2020-06-04.

Bacillus anthracisと遺伝的に近縁なBacillus cereusを保有するBa813が院内血流感染を引き起こした。細菌の病原性因子と臨床転帰

Ba813 harboring Bacillus cereus, genetically closely related to Bacillus anthracis, causing nosocomial bloodstream infection: Bacterial virulence factors and clinical outcome.
  • Tetsuji Aoyagi
  • Kengo Oshima
  • Shiro Endo
  • Hiroaki Baba
  • Hajime Kanamori
  • Makiko Yoshida
  • Koichi Tokuda
  • Mitsuo Kaku
  • PLoS ONE.2020;15(7):e0235771. PONE-D-20-02535. doi: 10.1371/journal.pone.0235771.Epub 2020-07-13.

ハーテル前方アプローチの代替法を用いたガッセリアンガングリオンのCT-誘導ラジオ波熱凝固術.両側からの研究

Computed Tomography-Guided Radiofrequency Thermocoagulation of the Gasserian Ganglion Using an Alternative to Hartel Anterior Approach: A Bicentral Study.
  • Dimitrios K Filippiadis
  • Dionysios Markoutsas
  • Argyro Mazioti
  • Grigorios Tsoukalos
  • Olympia Papakonstantinou
  • Panteleimon Stamatis
  • Alexis Kelekis
  • Dimitrios Tzavoulis
  • Pain Physician.2020 06;23(3):293-298.

中枢性早熟思春期の小児におけるDLK1の新たな遺伝学的および生化学的所見。ブラジルとスペインの研究

Novel Genetic and Biochemical Findings of DLK1 in Children with Central Precocious Puberty: A Brazilian-Spanish Study.
  • Luciana Montenegro
  • José I Labarta
  • Maira Piovesan
  • Ana P M Canton
  • Raquel Corripio
  • Leandro Soriano-Guillén
  • Lourdes Travieso-Suárez
  • Álvaro Martín-Rivada
  • Vicente Barrios
  • Carlos Seraphim
  • Vinicius N Brito
  • Ana Claudia Latronico
  • Jesús Argente
  • J. Clin. Endocrinol. Metab..2020 Jul;dgaa461. doi: 10.1210/clinem/dgaa461.Epub 2020-07-17.

Erratum.メトホルミンは、p38 MAPKの不活性化を介して卵巣肉芽細胞におけるテストステロン誘発性小胞体ストレスを抑制します

Erratum. Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK.
  • Jiamin Jin
  • Yerong Ma
  • Xiaomei Tong
  • Weijie Yang
  • Yongdong Dai
  • Yibin Pan
  • Peipei Ren
  • Liu Liu
  • Heng-Yu Fan
  • Yinli Zhang
  • Songying Zhang
  • Hum. Reprod..2020 Jul;deaa180. doi: 10.1093/humrep/deaa180.Epub 2020-07-09.

SARS-CoV-2コーディング配列過剰発現肺上皮細胞からの細胞外小胞による治療後のヒトiPSC-心筋細胞におけるウイルスRNA断片の検出

Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells.
  • Youjeong Kwon
  • Sarath Babu Nukala
  • Shubhi Srivastava
  • Hiroe Miyamoto
  • Nur Izzah Ismail
  • Jalees Rehman
  • Sang-Bing Ong
  • Won Hee Lee
  • Sang-Ging Ong
  • bioRxiv.2020 Jul;2020.05.14.093583. doi: 10.1101/2020.05.14.093583.Epub 2020-07-01.

行動性発声障害を有する被験者を対象とした、異なる半閉塞性声道運動に基づく生理学的音声療法プログラムの有効性。無作為化比較試験

Effectiveness of a physiologic voice therapy program based on different semioccluded vocal tract exercises in subjects with behavioral dysphonia: A randomized controlled trial.
  • Marco Guzman
  • Teresa Bertucci
  • Constanza Pacheco
  • Fernando Leiva
  • Felipe Quintana
  • Romina Ansaldi
  • Camilo Quezada
  • Daniel Muñoz
  • J Commun Disord.2020 Jul;87:106023. S0021-9924(20)30091-5. doi: 10.1016/j.jcomdis.2020.106023.Epub 2020-07-07.

概念分析とメタ・ナラティブ・レビューにより、複製研究の利用を改善するための包括的な理論的定義を確立した

A concept analysis and meta-narrative review established a comprehensive theoretical definition of replication research to improve its use.
  • Brigitte Vachon
  • Janet A Curran
  • Sathya Karunananthan
  • Jamie Brehaut
  • Ian D Graham
  • David Moher
  • Anne E Sales
  • Sharon E Straus
  • Michele Fiander
  • P Alison Paprica
  • Jeremy M Grimshaw
  • J Clin Epidemiol.2020 Jul;S0895-4356(20)30210-9. doi: 10.1016/j.jclinepi.2020.07.006.Epub 2020-07-16.

抗黒色腫分化関連遺伝子5抗体陽性皮膚筋炎における致死的かつ広範な多臓器出血．剖検例の報告

Fatal and extensive multiorgan hemorrhages in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis: An autopsy case report.
  • Tsuyoshi Watanabe
  • Naoho Takizawa
  • Toru Nagasaka
  • Yoshihiro Nakamura
  • Hiroki Ikai
  • Mari Yamamoto
  • Yukari Murai
  • Koji Takasugi
  • Waka Yokoyama-Kokuryo
  • Yoshiro Fujita
  • Medicine (Baltimore).2020 Jan;99(3):e18600. 00005792-202001170-00011. doi: 10.1097/MD.0000000000018600.

極低温シーケンスレイヤリングによる生体の3次元再構成

Cryogenic sequenced layering for the 3D reconstruction of biological objects.
  • Vladimir Nikolaevich Nikolenko
  • Alexey Anatolyevich Terpilovsky
  • Alexey Leonidovich Kuzmin
  • Regina Alekseevna Lukashkina
  • Alexey Evgenievich Strizhkov
  • Andrei Vladimirovich Suslov
  • Ekaterina Vladimirovna Kochurova
  • Liliya Vladimirovna Gavrushova
  • Mikhail Yegorovich Sinelnikov
  • Sci Rep.2020 Jul;10(1):11899. 10.1038/s41598-020-68682-z. doi: 10.1038/s41598-020-68682-z.Epub 2020-07-17.

クルクミンは神経炎症を緩和し、海馬の神経新生を高め、外傷性脳損傷後の空間記憶を改善します

Curcumin alleviates neuroinflammation, enhances hippocampal neurogenesis, and improves spatial memory after traumatic brain injury.
  • Guangchi Sun
  • Zong Miao
  • Yangfan Ye
  • Pengzhan Zhao
  • Liang Fan
  • Zhongyuan Bao
  • Yiming Tu
  • Chong Li
  • Honglu Chao
  • Xiupeng Xu
  • Jing Ji
  • Brain Res. Bull..2020 Sep;162:84-93. S0361-9230(20)30503-7. doi: 10.1016/j.brainresbull.2020.05.009.Epub 2020-06-02.

2型糖尿病ラットの肝組織におけるミトコンドリア生合成およびレドックス感受性転写因子に及ぼすトレーニングおよびクロシン補給の効果

Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats.
  • Fatemeh Davari
  • Zeynab Alimanesh
  • Zahra Alimanesh
  • Omidreza Salehi
  • Seyed Ali Hosseini
  • Arch. Physiol. Biochem..2020 May;:1-6. doi: 10.1080/13813455.2020.1762663.Epub 2020-05-13.

高緯度Tumanny観測所部分反射レーダー測定と極地物理学研究所のモデルに従った2017年3月1日から31日の間の地球の電離層D領域垂直電子密度プロファイルデータ

Earth's ionosphere D-region vertical electron density profile data during March 1-31, 2017 according to high-latitudinal Tumanny observatory partial reflection radar measurements and Polar Geophysical Institute's model.
  • Aleksandr Gomonov
  • Roman Yurik
  • Oleg Zolotov
  • Data Brief.2020 Aug;31:105848. S2352-3409(20)30742-3. doi: 10.1016/j.dib.2020.105848.Epub 2020-06-12.

硝酸塩の水中での触媒的水素化反応。ZrO-AlO上に担持されたRh(III)-ヘキサモリブデン酸塩を用いた活性とNに対する選択性の向上

Catalytic hydrogenation of nitrate in water. Improvement of the activity and selectivity to N by using Rh(III)-hexamolybdate supported on ZrO-AlO.
  • María A Jaworski
  • Marisa Navas
  • Guillermo R Bertolini
  • María B Peroni
  • Carmen I Cabello
  • Delia Gazzoli
  • Mónica L Casella
  • Environ Technol.2020 Jul;:1-37. doi: 10.1080/09593330.2020.1797895.Epub 2020-07-17.

サイクリン B タンパク質は、淡水海老とミトンガニの卵子の減数分裂成熟期に発現量が増加し、核内に再配置されます

Cyclin B protein undergoes increased expression and nuclear relocation during oocyte meiotic maturation of the freshwater prawn Macrobrachium rosenbergii and the Chinese mitten crab Eriocheir sinensis.
  • Haiyang Feng
  • Yao-Ting Dong
  • Xue Liu
  • Gao-Feng Qiu Writing-Review
  • Editing
  • Gene.2020 Jul;:144955. S0378-1119(20)30624-7. doi: 10.1016/j.gene.2020.144955.Epub 2020-07-16.

ドキソルビシン/シクロデキストリン-グラフェンナノ材料の亜毒性濃度での細胞内動態と遺伝子発現への影響

Intracellular Fate and Impact on Gene Expression of Doxorubicin/Cyclodextrin-Graphene Nanomaterials at Sub-Toxic Concentration.
  • Daniela Caccamo
  • Monica Currò
  • Riccardo Ientile
  • Elisabetta Am Verderio
  • Angela Scala
  • Antonino Mazzaglia
  • Rosamaria Pennisi
  • Maria Musarra-Pizzo
  • Roberto Zagami
  • Giulia Neri
  • Consolato Rosmini
  • Monica Potara
  • Monica Focsan
  • Simion Astilean
  • Anna Piperno
  • Maria Teresa Sciortino
  • Int J Mol Sci.2020 Jul;21(14). E4891. doi: 10.3390/ijms21144891.Epub 2020-07-10.

舌側エナメル質形態とブラケットのせん断接着強さに及ぼすNd:YAGレーザーと酸化アルミニウムサンドブラスト前処理の影響

The lingual enamel morphology and bracket shear bond strength influenced by Nd:YAG laser and aluminum oxide sandblasting preconditioning.
  • Mônica Schäffer Lopes
  • Daísa Lima Pereira
  • Cláudia Cristina Brainer de Oliveira Mota
  • Marcello Magri Amaral
  • Denise Maria Zezell
  • Anderson Stevens Leonidas Gomes
  • Clin Oral Investig.2020 Jun;10.1007/s00784-020-03418-x. doi: 10.1007/s00784-020-03418-x.Epub 2020-06-30.

新生児および乳児胸腺における加齢に関連した転写モジュールとTF-miRNA-mRNA相互作用

Age-related transcriptional modules and TF-miRNA-mRNA interactions in neonatal and infant human thymus.
  • Fernanda Bernardi Bertonha
  • Silvia Yumi Bando
  • Leandro Rodrigues Ferreira
  • Paulo Chaccur
  • Christiana Vinhas
  • Maria Claudia Nogueira Zerbini
  • Magda Maria Carneiro-Sampaio
  • Carlos Alberto Moreira-Filho
  • PLoS ONE.2020;15(4):e0227547. PONE-D-19-27724. doi: 10.1371/journal.pone.0227547.Epub 2020-04-15.

糞便カルプロテキンは、生物学的治療を受けた潰瘍性大腸炎患者の粘膜治癒を予測する。プロスペクティブ研究

Fecal Calprotectin Predicts Mucosal Healing in Patients With Ulcerative Colitis Treated With Biological Therapies: A Prospective Study.
  • Lorenzo Bertani
  • Corrado Blandizzi
  • Maria Gloria Mumolo
  • Linda Ceccarelli
  • Eleonora Albano
  • Gherardo Tapete
  • Giovanni Baiano Svizzero
  • Federico Zanzi
  • Francesca Coppini
  • Nicola de Bortoli
  • Massimo Bellini
  • Riccardo Morganti
  • Santino Marchi
  • Francesco Costa
  • Clin Transl Gastroenterol.2020 May;11(5):e00174. 01720094-202005000-00003. doi: 10.14309/ctg.0000000000000174.

コリンエステラーゼ阻害薬の切り替えを受けた軽度～中等度アルツハイマー病患者における精神神経症状の性差．EVOLUTION試験のポストホック解析

Gender Differences in Neuropsychiatric Symptoms in Mild to Moderate Alzheimer's Disease Patients Undergoing Switch of Cholinesterase Inhibitors: A Post Hoc Analysis of the EVOLUTION Study.
  • Delia Colombo
  • Carlo Caltagirone
  • Alessandro Padovani
  • Sandro Sorbi
  • Gianfranco Spalletta
  • Lucia Simoni
  • Alessandra Ori
  • Emanuela Zagni
  • J Womens Health (Larchmt).2018 11;27(11):1368-1377. doi: 10.1089/jwh.2017.6420.Epub 2018-09-08.

韓国におけるB細胞非ホジキンリンパ腫の増加と二次悪性腫瘍の発生：韓国国民健康情報データベースを用いた10年間の追跡調査

Increasing Incidence of B-Cell Non-Hodgkin Lymphoma and Occurrence of Second Primary Malignancies in South Korea: 10-Year Follow-up Using the Korean National Health Information Database.
  • Jin Seok Kim
  • Yanfang Liu
  • Kyoung Hwa Ha
  • Hong Qiu
  • Lee Anne Rothwell
  • Hyeon Chang Kim
  • Cancer Res Treat.2020 05;crt.2020.089. doi: 10.4143/crt.2020.089.Epub 2020-05-04.

リソソーム関連膜タンパク質-2の欠乏は、網膜色素上皮細胞における活性酸素誘発性フェロプトーシスのリスクを増加させる

Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells.
  • Jong-Jer Lee
  • Kenji Ishihara
  • Shoji Notomi
  • Nikolaos E Efstathiou
  • Takashi Ueta
  • Daniel Maidana
  • Xiaohong Chen
  • Yasuhiro Iesato
  • Alberto Caligiana
  • Demetrios G Vavvas
  • Biochem. Biophys. Res. Commun..2020 01;521(2):414-419. S0006-291X(19)32046-7. doi: 10.1016/j.bbrc.2019.10.138.Epub 2019-10-28.

漢方薬中の16種類の多環芳香族炭化水素の定量のための同位体希釈ガスクロマトグラフィー質量分析法と結合した磁性Cナノスフェアベースの固相抽出法

Magnetic C nanospheres based solid-phase extraction coupled with isotope dilution gas chromatography-mass spectrometry method for the determination of sixteen polycyclic aromatic hydrocarbons in Chinese herbal medicines.
  • Dian-Bing Zhou
  • Fang Han
  • Lei Ding
  • Wei Song
  • Ya-Ning Lv
  • Yan-Yun Hu
  • Yu-Xin Liu
  • Xuan Sheng
  • Ping Zheng
  • J. Chromatogr. B Analyt. Technol. Biomed. Life Sci..2020 May;1144:122076. S1570-0232(19)31667-8. doi: 10.1016/j.jchromb.2020.122076.Epub 2020-03-20.

DAPA-HF試験における心不全・駆出率低下患者におけるダパグリフロジンと利尿薬使用の検討

Dapagliflozin and Diuretic Use in Patients with Heart Failure and Reduced Ejection Fraction in DAPA-HF.
  • Alice M Jackson
  • Pooja Dewan
  • Inder S Anand
  • Jan Bělohlávek
  • Olof Bengtsson
  • Rudolf A de Boer
  • Michael Böhm
  • David W Boulton
  • Vijay K Chopra
  • David L Demets
  • Kieran F Docherty
  • Andrej Dukát
  • Peter J Greasley
  • Jonathan G Howlett
  • Silvio E Inzucchi
  • Tzvetana Katova
  • Lars Køber
  • Mikhail N Kosiborod
  • Anna Maria Langkilde
  • Daniel Lindholm
  • Charlotta E A Ljungman
  • Felipe A Martinez
  • Eileen O'Meara
  • Marc S Sabatine
  • Mikaela Sjöstrand
  • Scott D Solomon
  • Sergey Tereshchenko
  • Subodh Verma
  • Pardeep S Jhund
  • John J V McMurray
  • Circulation.2020 Jul;doi: 10.1161/CIRCULATIONAHA.120.047077.Epub 2020-07-16.

生物学的・免疫調節療法の併用は単剤治療よりも優れており、炎症性腸疾患関連合併症のリスクを低下させることができる

Combined Biologic and Immunomodulatory Therapy is Superior to Monotherapy for Decreasing the Risk of Inflammatory Bowel Disease-Related Complications.
  • Laura E Targownik
  • Eric I Benchimol
  • Charles N Bernstein
  • Harminder Singh
  • Aruni Tennakoon
  • Antonio Aviña Zubieta
  • Stephanie Coward
  • Jennifer Jones
  • Gilaad G Kaplan
  • M Ellen Kuenzig
  • Sanjay K Murthy
  • Geoffrey C Nguyen
  • Juan Nicolás Peña-Sánchez
  • J Crohns Colitis.2020 Jul;jjaa050. doi: 10.1093/ecco-jcc/jjaa050.Epub 2020-07-10.

陸上植物の油体形成はMpC1HDZによって制御されており、節足動物の草食動物に対する防御として機能している

Oil Body Formation in Marchantia polymorpha Is Controlled by MpC1HDZ and Serves as a Defense against Arthropod Herbivores.
  • Facundo Romani
  • Elizabeta Banić
  • Stevie N Florent
  • Takehiko Kanazawa
  • Jason Q D Goodger
  • Remco A Mentink
  • Tom Dierschke
  • Sabine Zachgo
  • Takashi Ueda
  • John L Bowman
  • Miltos Tsiantis
  • Javier E Moreno
  • Curr. Biol..2020 Jun;S0960-9822(20)30768-5. doi: 10.1016/j.cub.2020.05.081.Epub 2020-06-11.

キトサンでコーティングされた「病原体のような」粘接着性ナノワクチンによるティラピアのカラムナリス病に対する浸漬ワクチン接種の有効性の向上

Enhanced efficacy of immersion vaccination in tilapia against columnaris disease by chitosan-coated "pathogen-like" mucoadhesive nanovaccines.
  • Sirikorn Kitiyodom
  • Teerapong Yata
  • Jakarwan Yostawornkul
  • Somrudee Kaewmalun
  • Naiyaphat Nittayasut
  • Kunat Suktham
  • Suvimol Surassmo
  • Katawut Namdee
  • Channarong Rodkhum
  • Nopadon Pirarat
  • Fish Shellfish Immunol..2019 Dec;95:213-219. S1050-4648(19)30948-9. doi: 10.1016/j.fsi.2019.09.064.Epub 2019-10-01.

ε-ポリリジンを含むキトサンおよびアルギン酸ナトリウム活性コーティングの低温保存中の養殖フグ（Takifugu obscurus）の品質への影響

Effects of chitosan and sodium alginate active coatings containing ε-polysine on qualities of cultured pufferfish (Takifugu obscurus) during cold storage.
  • Peiyun Li
  • Qianqian Zhou
  • Yuanming Chu
  • Weiqing Lan
  • Jun Mei
  • Jing Xie
  • Int. J. Biol. Macromol..2020 May;160:418-428. S0141-8130(20)33247-5. doi: 10.1016/j.ijbiomac.2020.05.092.Epub 2020-05-15.

アロキサン誘発糖尿病ラットを対象とした絶滅危惧植物の水性葉抽出物のファイトケミカルスクリーニングと抗糖尿病能の確立

Phytochemical Screening and Establishment of the Antidiabetic Potential of Aqueous Leaf Extract of the Endangered Plant in Rats with Alloxan-induced Diabetes.
  • Kuntal DAS
  • Saifulla Khan M
  • James Sounder
  • Usha Mohan
  • Venkatesh Prasad S
  • Turk J Pharm Sci.2020 Jun;17(3):319-328. 27996. doi: 10.4274/tjps.galenos.2019.47135.Epub 2020-06-22.

甲殻類高血糖ホルモン（CHH）ファミリー（CHH、脱皮抑制ホルモン、下顎器官抑制ホルモン）の分子クローニングとその発現量の解析

Molecular cloning of crustacean hyperglycemic hormone (CHH) family members (CHH, molt-inhibiting hormone and mandibular organ-inhibiting hormone) and their expression levels in the Jonah crab, Cancer borealis.
  • J Sook Chung
  • A Christie
  • E Flynn
  • Gen. Comp. Endocrinol..2020 May;295:113522. S0016-6480(20)30275-6. doi: 10.1016/j.ygcen.2020.113522.Epub 2020-05-31.

コロナウイルスパンデミック時の大規模多専門病院のCOVID-19専用センターへの転換

Transformation of a large multi-speciality hospital into a dedicated COVID-19 centre during the coronavirus pandemic.
  • Zbigniew Król
  • Piotr Szymański
  • Adrian Bochnia
  • Emilia Abramowicz
  • Agnieszka Płachta
  • Radosław Rzepliński
  • Mikołaj Sługocki
  • Błażej Nowak
  • Artur Zaczyński
  • Krzysztof Kozłowski
  • Marek Posobkiewicz
  • Waldemar Wierzba
  • Ann Agric Environ Med.2020 Jun;27(2):201-206. 123801. doi: 10.26444/aaem/123801.Epub 2020-06-16.

神経薬サリンの代替物質であるフッ化リン酸ジイソプロピル（DFP）中毒後のラット血漿のプロテオーム解析の差動解析

Differential proteome analysis of rat plasma after diisopropyl fluorophosphate (DFP) intoxication, a surrogate of nerve agent sarin.
  • Kalyani Chaubey
  • Syed Imteyaz Alam
  • Chandra Kant Waghmare
  • Lokendra Singh
  • Nalini Srivastava
  • Bijoy K Bhattacharya
  • Chem. Biol. Interact..2019 Jan;298:66-71. S0009-2797(18)30513-1. doi: 10.1016/j.cbi.2018.10.026.Epub 2018-10-30.

マダガスカルの博物館"ラ・スペコラ"が1989/1991年に採集したミリペッドについて、3種の新種のジャイアントピルミリペッド(Diplopoda, Sphaerotheriida, Arthrosphaeridae)の記述を交えて紹介しています

The millipedes collected by the Museum "La Specola" on Madagascar 1989/1991, with the description of three new species of giant pill-millipedes (Diplopoda, Sphaerotheriida, Arthrosphaeridae).
  • Thomas Wesener
  • Pooja Avinipully Anilkumar
  • Zookeys.2020;930:3-35. 47620. doi: 10.3897/zookeys.930.47620.Epub 2020-04-28.

トレメラ類似のZnO@Col-I修飾チタン表面は、二重に光で定義された広スペクトルの抗菌性と三重の骨形成特性を有する

Tremella-Like ZnO@Col-I-Decorated Titanium Surfaces with Dual-Light-Defined Broad-Spectrum Antibacterial and Triple Osteogenic Properties.
  • Siyu Zhao
  • Yingying Xu
  • Wenying Xu
  • Zhenzhen Weng
  • Fei Cao
  • Xinyi Wan
  • Tongcan Cui
  • Yajun Yu
  • Lan Liao
  • Xiaolei Wang
  • ACS Appl Mater Interfaces.2020 Jul;12(27):30044-30051. doi: 10.1021/acsami.0c05413.Epub 2020-06-26.

筋炎特異的抗体が自己免疫性間質性肺炎の表現型を識別する

Myositis-specific Antibodies Identify A Distinct Interstitial Pneumonia with Autoimmune Features Phenotype.
  • Julia Graham
  • Iazsmin Bauer Ventura
  • Chad A Newton
  • Cathryn Lee
  • Noelle Boctor
  • Janelle Vu Pugashetti
  • Claire Cutting
  • Elena Joerns
  • Habrinder Sandhu
  • Jonathan H Chung
  • Christine Kim Garcia
  • Michael Kadoch
  • Imre Noth
  • Ayodeji Adegunsoye
  • Mary E Strek
  • Justin M Oldham
  • Eur. Respir. J..2020 Jul;2001205. doi: 10.1183/13993003.01205-2020.Epub 2020-07-16.

リウマチ性疾患におけるオピオイド鎮痛薬の役割：ポルトガルリウマチ学会のポジションペーパー

The role of opioid analgesics in rheumatic disorders: a position paper from the Portuguese Rheumatology Society.
  • Soraia Azevedo
  • Francisca Guimarães
  • Joana Leite Silva
  • Rita Barros
  • Susana Capela
  • Pedro Abreu
  • Luís Cunha Miranda
  • Eduardo Dourado
  • Augusto Faustino
  • Joana Ferreira
  • Vera Las
  • Filipe Martins
  • Teresa Martins Rocha
  • Tiago Meirinhos
  • Maria João Salvador
  • Daniela Santos-Faria
  • Marília Soares Rodrigues
  • Filipa Teixeira
  • Inês Cunha
  • Acta Reumatol Port.2020 Jan-Mar;45(1):7-19. AR190268.

アスリートの健康を守る。質的研究が重要な理由

Athlete health protection: Why qualitative research matters.
  • Sheree Bekker
  • Caroline Bolling
  • Osman H Ahmed
  • Marelise Badenhorst
  • Joel Carmichael
  • Kristina Fagher
  • Martin Hägglund
  • Jenny Jacobsson
  • Jannika M John
  • Karen Litzy
  • Robert H Mann
  • Carly D McKay
  • Stephen Mumford
  • Montassar Tabben
  • Ansgar Thiel
  • Toomas Timpka
  • Joanna Thurston
  • Linda K Truong
  • Jörg Spörri
  • Femke van Nassau
  • Evert Alm Verhagen
  • J Sci Med Sport.2020 Jul;S1440-2440(20)30682-4. doi: 10.1016/j.jsams.2020.06.020.Epub 2020-07-03.

日常生活における低血糖症状のある患者とない患者のRoux-en-Y胃バイパス術後の経口ブドウ糖負荷試験の特徴：それはすべて速度に関係している

Features of oral glucose tolerance test in patients after Roux-en-Y gastric bypass with and without hypoglycaemia symptoms in daily life: it's all about speed.
  • Ilke Marien
  • Christophe De Block
  • An Verrijken
  • Kristof Van Dessel
  • Frida Peiffer
  • Ann Verhaegen
  • Guy Hubens
  • Luc Van Gaal
  • Eveline Dirinck
  • Diabetes Obes Metab.2020 Jul;doi: 10.1111/dom.14130.Epub 2020-07-09.

総アディポネクチン、高分子量アディポネクチン、選択されたソマトメジン、および喫煙者と非喫煙者の母親の乳児の出生体重の母体および胎児レベルとの関連

Associations between Maternal and Fetal Levels of Total Adiponectin, High Molecular Weight Adiponectin, Selected Somatomedins, and Birth Weight of Infants of Smoking and Non-Smoking Mothers.
  • Magdalena Chełchowska
  • Joanna Gajewska
  • Tomasz M Maciejewski
  • Joanna Mazur
  • Mariusz Ołtarzewski
  • Jadwiga Ambroszkiewicz
  • Int J Environ Res Public Health.2020 Jul;17(13). E4781. doi: 10.3390/ijerph17134781.Epub 2020-07-03.

ルチンを豊富に含むオトギリソウ抽出物は、ラットのターペンチンオイル誘発性炎症に対して抗炎症作用を示す

Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats.
  • Anca D Farcas
  • Augustin C Mot
  • Cezara Zagrean-Tuza
  • Madalina Ticolea
  • Bogdan Sevastre
  • Muhittin Kulak
  • Radu Silaghi-Dumitrescu
  • Alina Parvu
  • BMC Complement Altern Med.2019 Oct;19(1):289. 10.1186/s12906-019-2680-8. doi: 10.1186/s12906-019-2680-8.Epub 2019-10-29.

SMPD1遺伝子のディープシークエンシングにより、パレスチナ人のニーマンピック病A型乳児にヘテロ接合性フレームシフト変異(p.Ser192Alafs)が認められた

Deep sequencing of SMPD1 gene revealed a heterozygous frameshift mutation (p.Ser192Alafs) in a Palestinian infant with Niemann-Pick disease type A: a case report.
  • Abedelmajeed Nasereddin
  • Suheir Ereqat
  • J Med Case Rep.2018 Sep;12(1):272. 10.1186/s13256-018-1805-x. doi: 10.1186/s13256-018-1805-x.Epub 2018-09-18.

画像誘導型腫瘍光力学療法のためのデュアルモーダルイメージングプラットフォームとしての凝集誘導発光とMRIコントラスト増強特性を有するセラノーシスナノ粒子

Theranostic Nanoparticles with Aggregation-Induced Emission and MRI Contrast Enhancement Characteristics as a Dual-Modal Imaging Platform for Image-Guided Tumor Photodynamic Therapy.
  • Huikang Yang
  • Yufang He
  • Yan Wang
  • Ruimeng Yang
  • Nianhua Wang
  • Li-Ming Zhang
  • Meng Gao
  • Xinqing Jiang
  • Int J Nanomedicine.2020;15:3023-3038. 244541. doi: 10.2147/IJN.S244541.Epub 2020-04-30.

未処理排水の灌漑によるニッケル汚染土壌の浄化における稲わらバイオ炭、硫黄、ライグラス（L

Potential of rice straw biochar, sulfur and ryegrass ( L.) in remediating soil contaminated with nickel through irrigation with untreated wastewater.
  • Inas A Hashem
  • Aonalah Y Abbas
  • Abo El-Nasr H Abd El-Hamed
  • Haythum M S Salem
  • Omr E M El-Hosseiny
  • Mohamed A Abdel-Salam
  • Muhammad Hamzah Saleem
  • Wenbing Zhou
  • Ronggui Hu
  • PeerJ.2020;8:e9267. 9267. doi: 10.7717/peerj.9267.Epub 2020-06-12.

下肢動脈疾患を有する糖尿病患者の血管内治療の臨床転帰に及ぼす前段階の血糖コントロールの影響：韓国の多施設レトロスペクティブ登録コホートからの分析

Influence of preprocedural glycemic control on clinical outcomes of endovascular therapy in diabetic patients with lower extremity artery disease: an analysis from a Korean multicenter retrospective registry cohort.
  • Jung-Joon Cha
  • Hyoeun Kim
  • Young-Guk Ko
  • Donghoon Choi
  • Jae-Hwan Lee
  • Chang-Hwan Yoon
  • In-Ho Chae
  • Cheol Woong Yu
  • Seung Whan Lee
  • Sang-Rok Lee
  • Seung Hyuk Choi
  • Yoon Seok Koh
  • Pil-Ki Min
  • Cardiovasc Diabetol.2020 Jun;19(1):97. 10.1186/s12933-020-01072-x. doi: 10.1186/s12933-020-01072-x.Epub 2020-06-22.

ベルギーにおける胎盤パラベン負荷の関数としての出生時の体重と頭囲：ENVIRONAGE出生コホート研究

Weight and head circumference at birth in function of placental paraben load in Belgium: an ENVIRONAGE birth cohort study.
  • Karen Vrijens
  • Ilse Van Overmeire
  • Koen De Cremer
  • Kristof Y Neven
  • Riccardo M Carollo
  • Christiane Vleminckx
  • Joris Van Loco
  • Tim S Nawrot
  • Environ Health.2020 Jul;19(1):83. 10.1186/s12940-020-00635-5. doi: 10.1186/s12940-020-00635-5.Epub 2020-07-14.

腎臓における近位尿細管特異的なNHE3（Na/H交換体3）の欠失は、マウスのAng II（アンジオテンシンII）誘発性高血圧を減衰させる

Proximal Tubule-Specific Deletion of the NHE3 (Na/H Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice.
  • Xiao C Li
  • Dongmin Zhu
  • Xu Chen
  • Xiaowen Zheng
  • Chunling Zhao
  • Jianfeng Zhang
  • Manoocher Soleimani
  • Isabelle Rubera
  • Michel Tauc
  • Xinchun Zhou
  • Jia L Zhuo
  • Hypertension.2019 09;74(3):526-535. doi: 10.1161/HYPERTENSIONAHA.119.13094.Epub 2019-07-29.

4人の血縁関係にあるパキスタン人血統において、ITGB3遺伝子の2つのホモ接合型ミスセンス変異がグランツマン血小板減少症の原因となっていることを明らかにした

Two homozygous missense mutations in ITGB3 gene as a cause of Glanzmann Thrombasthenia in four consanguineous Pakistani pedigrees.
  • Tooba Ali
  • Saira Gul
  • Ali Amar
  • Madiha Shakoor
  • Saima Farhan
  • Shahida Mohsin
  • Shagufta Khaliq
  • Int J Lab Hematol.2020 Jun;doi: 10.1111/ijlh.13266.Epub 2020-06-19.

ダパグリフロジンとリラグルチド療法は、2型糖尿病マウスモデルにおける骨形成部位の骨材料特性とマトリックスバイオメカニクスを急速に増強した

Dapagliflozin and Liraglutide Therapies Rapidly Enhanced Bone Material Properties and Matrix Biomechanics at Bone Formation Site in a Type 2 Diabetic Mouse Model.
  • Aleksandra Mieczkowska
  • Paul Millar
  • Daniel Chappard
  • Victor A Gault
  • Guillaume Mabilleau
  • Calcif. Tissue Int..2020 Jul;10.1007/s00223-020-00720-4. doi: 10.1007/s00223-020-00720-4.Epub 2020-07-08.

NHERF3は熱安定性エントロトキシンによるNHE3の阻害に必要：マウス小腸とCaco-2細胞におけるシグナル伝達の違い

NHERF3 is necessary for heat-stable enterotoxin-induced inhibition of NHE3: differences in signaling in mouse small intestine and Caco-2 cells.
  • Tiane Chen
  • Ruxian Lin
  • Leela Avula
  • Rafiquel Sarker
  • Jianbo Yang
  • Boyoung Cha
  • Chung Ming Tse
  • George McNamara
  • Ursula Seidler
  • Scott Waldman
  • Adam Snook
  • Marcel J C Bijvelds
  • Hugo R de Jonge
  • Xuhang Li
  • Mark Donowitz
  • Am. J. Physiol., Cell Physiol..2019 10;317(4):C737-C748. doi: 10.1152/ajpcell.00351.2018.Epub 2019-07-31.

C型肝炎ウイルスが感染患者のHIV-1ウイルススプライシングに影響を与える

Hepatitis C Virus Influences HIV-1 Viral Splicing in Coinfected Patients.
  • Paula Martínez-Román
  • María Rosa López-Huertas
  • Celia Crespo-Bermejo
  • Sonia Arca-Lafuente
  • Isabel Cortegano
  • Daniel Valle-Millares
  • María Luisa Gaspar
  • Luz Martín-Carbonero
  • Lourdes Domínguez-Domínguez
  • Pablo Ryan
  • Ignacio de Los Santos
  • Sara de la Fuente-Moral
  • Amanda Fernández-Rodríguez
  • Mayte Coiras
  • Verónica Briz
  • J Clin Med.2020 Jul;9(7). E2091. doi: 10.3390/jcm9072091.Epub 2020-07-03.

ヘテロ-ビス-ランタニドペプチドコンジュゲートのサイト特異的合成のためのネイティブケミカルライゲーションを使用しています。Zn2のレシオメトリックな可視または近赤外検出への応用

Using Native Chemical Ligation for Site-specific Synthesis of Hetero-bis-lanthanide Peptide Conjugates: Application to Ratiometric Visible or Near-infrared Detection of Zn2.
  • Céline Cepeda
  • Laurent Raibaut
  • Guillaume Fremy
  • Svetlana V Eliseeva
  • Anthony Romieu
  • Jacques Pécaut
  • Didier Boturyn
  • Stéphane Petoud
  • Olivier Seneque
  • Chemistry.2020 Jul;doi: 10.1002/chem.202002708.Epub 2020-07-01.

金ナノザイムは、比色バイオアッセイや光熱バイオアッセイの性能を向上させるための優れた共触媒として利用されています

Gold nanozyme as an excellent co-catalyst for enhancing the performance of a colorimetric and photothermal bioassay.
  • Pengli An
  • Xin Xue
  • Honghong Rao
  • Jingjing Wang
  • Min Gao
  • Hongqiang Wang
  • Mingyue Luo
  • Xiuhui Liu
  • Zhonghua Xue
  • Xiaoquan Lu
  • Anal. Chim. Acta.2020 Aug;1125:114-127. S0003-2670(20)30599-7. doi: 10.1016/j.aca.2020.05.047.Epub 2020-05-23.

IFN調節因子-1は急性冠症候群患者においてcirc_0029589のm6A修飾を調節することでマクロファージのパイロプトーシスを誘導することがわかった

IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome.
  • Min Guo
  • Rui Yan
  • Qingwei Ji
  • Hongmei Yao
  • Meng Sun
  • Liqin Duan
  • Zheng Xue
  • Yongping Jia
  • Int. Immunopharmacol..2020 Jul;86:106800. S1567-5769(20)30936-X. doi: 10.1016/j.intimp.2020.106800.Epub 2020-07-13.

葉酸ストレスは、ヒト細胞の壊れやすいX遺伝子座においてSLX1およびRAD51依存性の分裂性DNA合成を誘導する

Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells.
  • Lorenza Garribba
  • Victoria A Bjerregaard
  • Marisa M Gonçalves Dinis
  • Özgün Özer
  • Wei Wu
  • Despoina Sakellariou
  • Javier Pena-Diaz
  • Ian D Hickson
  • Ying Liu
  • Proc. Natl. Acad. Sci. U.S.A..2020 Jul;117(28):16527-16536. 1921219117. doi: 10.1073/pnas.1921219117.Epub 2020-06-29.

フルクトースは、ケトヘキナーゼに依存する腎近位尿細管におけるナトリウム水素交換体の活性を増加させる

Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase.
  • Takahiro Hayasaki
  • Takuji Ishimoto
  • Tomohito Doke
  • Akiyoshi Hirayama
  • Tomoyoshi Soga
  • Kazuhiro Furuhashi
  • Noritoshi Kato
  • Tomoki Kosugi
  • Naotake Tsuboi
  • Miguel A Lanaspa
  • Richard J Johnson
  • Shoichi Maruyama
  • Kenji Kadomatsu
  • J. Nutr. Biochem..2019 09;71:54-62. S0955-2863(18)31138-0. doi: 10.1016/j.jnutbio.2019.05.017.Epub 2019-06-08.

真菌の鉄キレート剤デスフェリコプロゲンが動脈硬化性プラーク形成を抑制する

The Fungal Iron Chelator Desferricoprogen Inhibits Atherosclerotic Plaque Formation.
  • László Potor
  • Sikura Katalin Éva
  • Hajnalka Hegedűs
  • Dávid Pethő
  • Zsuzsa Szabó
  • Zsuzsa M Szigeti
  • István Pócsi
  • György Trencsényi
  • Dezső Szikra
  • Ildikó Garai
  • Tamás Gáll
  • Zsolt Combi
  • János Kappelmayer
  • György Balla
  • József Balla
  • Int J Mol Sci.2020 Jul;21(13). E4746. doi: 10.3390/ijms21134746.Epub 2020-07-03.

頭蓋内動脈瘤破裂状態の識別：患者固有の流入境界は血行動態シミュレーションでは必須条件ではないかもしれない

Discrimination of intracranial aneurysm rupture status: patient-specific inflow boundary may not be a must-have condition in hemodynamic simulations.
  • Wenqiang Li
  • Shengzhang Wang
  • Zhongbin Tian
  • Wei Zhu
  • Yisen Zhang
  • Ying Zhang
  • Yang Wang
  • Kun Wang
  • Xinjian Yang
  • Jian Liu
  • Neuroradiology.2020 Jun;10.1007/s00234-020-02473-1. doi: 10.1007/s00234-020-02473-1.Epub 2020-06-25.

アロエベラゲルを含有し、塩化亜鉛で架橋したアルジネートフィルムの創傷治癒効果の評価

Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride.
  • Adriana Yuriko Koga
  • Julio César Felix
  • Rodrigo Gomes Marques Silvestre
  • Leandro Cavalcante Lipinski
  • Bruna Carletto
  • Fernanda Alexia Kawahara
  • Airton Vicente Pereira
  • Acta Cir Bras.2020 Jul;35(5):e202000507. S0102-86502020000500204. doi: 10.1590/s0102-865020200050000007.Epub 2020-07-03.

スマッド相互作用タンパク質1は、細胞外マトリックスタンパク質産生および肥大性瘢痕形成におけるトランスフォーミング成長因子-β/スマッドシグナルに影響を与える

Smad interacting protein 1 influences transforming growth factor-β/Smad signaling in extracellular matrix protein production and hypertrophic scar formation.
  • Xiaobing Fang
  • Xiaolong Hu
  • Zhao Zheng
  • Ke Tao
  • Hongtao Wang
  • Hao Guan
  • Jihong Shi
  • Peng Ji
  • Weixia Cai
  • Xiaozhi Bai
  • Xiongxiang Zhu
  • Juntao Han
  • Jiaqi Liu
  • Dahai Hu
  • J. Mol. Histol..2019 Dec;50(6):503-514. 10.1007/s10735-019-09844-w. doi: 10.1007/s10735-019-09844-w.Epub 2019-10-08.

特発性非タスク特異的上肢ジストニア、無視されてきたジストニアの一形態

Idiopathic Non-Task-Specific Upper Limb Dystonia, a Neglected Form of Dystonia.
  • Giovanni Defazio
  • Tommaso Ercoli
  • Roberto Erro
  • Roberta Pellicciari
  • Marcello Mario Mascia
  • Giovanni Fabbrini
  • Alberto Albanese
  • Stefania Lalli
  • Roberto Eleopra
  • Paolo Barone
  • Roberta Marchese
  • Roberto Ceravolo
  • Cesa Scaglione
  • Rocco Liguori
  • Marcello Esposito
  • Anna Rita Bentivoglio
  • Laura Bertolasi
  • Maria Concetta Altavista
  • Francesco Bono
  • Antonio Pisani
  • Paolo Girlanda
  • Alfredo Berardelli
  • Mov. Disord..2020 Jul;doi: 10.1002/mds.28199.Epub 2020-07-14.

葉面上の2つのPAHの光分解と生分解の役割。都市の樹木が提供する大気質生態系サービスへの影響のモデル化

Role of photo- and biodegradation of two PAHs on leaves: Modelling the impact on air quality ecosystem services provided by urban trees.
  • Elisa Terzaghi
  • Flavia De Nicola
  • Bruno E L Cerabolini
  • Rosa Posada-Baquero
  • Josè-J Ortega-Calvo
  • Antonio Di Guardo
  • Sci. Total Environ..2020 Jun;739:139893. S0048-9697(20)33413-6. doi: 10.1016/j.scitotenv.2020.139893.Epub 2020-06-06.

ＦＲＡオクタザイムＣドライの安全性・有効性（えんどう-１，４-β-キシラナーゼ、マンナン-えんどう-１，４-β-マンノシダーゼ、α-アミラーゼ、えんどう-１，３(４)-β-グルカナーゼ、ペクチナーゼ、エンド-１，４-β-グルカナーゼ、プロテアーゼ、α-ガラクトシダーゼ）を配合した肥育用離乳子豚・鶏用飼料添加物

Safety and efficacy of FRA Octazyme C Dry (endo-1,4-β-xylanase, mannan-endo-1,4-β-mannosidase, α-amylase, endo-1,3(4)-β-glucanase, pectinase, endo-1,4-β-glucanase, protease, α-galactosidase) as a feed additive for weaned piglets and chickens for fattening.
  • Vasileios Bampidis
  • Giovanna Azimonti
  • Maria de Lourdes Bastos
  • Henrik Christensen
  • Birgit Dusemund
  • Maryline Kouba
  • Mojca Kos Durjava
  • Marta López-Alonso
  • Secundino López Puente
  • Francesca Marcon
  • Baltasar Mayo
  • Alena Pechová
  • Mariana Petkova
  • Fernando Ramos
  • Yolanda Sanz
  • Roberto Edoardo Villa
  • Ruud Woutersen
  • Montserrat Anguita
  • EFSA J.2019 Jun;17(6):e05730. EFS25730. doi: 10.2903/j.efsa.2019.5730.Epub 2019-06-18.

遠隔虚血性前処理は、二重抗血小板療法を受けている冠動脈疾患患者における血小板αβ活性化を抑制する。冠動脈疾患患者の血小板活性化を阻害することを目的とした無作為化試験

Remote ischemic preconditioning inhibits platelet α β activation in coronary artery disease patients receiving dual antiplatelet therapy: A randomized trial.
  • Jerrett K Lau
  • Gabrielle J Pennings
  • Caroline J Reddel
  • Heather Campbell
  • Hai Po H Liang
  • Mathew Traini
  • Elizabeth E Gardiner
  • Andy S Yong
  • Vivien M Chen
  • Leonard Kritharides
  • J. Thromb. Haemost..2020 May;18(5):1221-1232. doi: 10.1111/jth.14763.Epub 2020-03-13.

自己抗体プロファイルはブルガダ症候群を検出し、異常に発現した心筋蛋白質を同定する

An autoantibody profile detects Brugada syndrome and identifies abnormally expressed myocardial proteins.
  • Diptendu Chatterjee
  • Maurizio Pieroni
  • Meena Fatah
  • Flavien Charpentier
  • Kristopher S Cunningham
  • Danna A Spears
  • Dipashree Chatterjee
  • Gonca Suna
  • J Martjin Bos
  • Michael J Ackerman
  • Eric Schulze-Bahr
  • Sven Dittmann
  • Pasquale G Notarstefano
  • Leonardo Bolognese
  • Firat Duru
  • Ardan M Saguner
  • Robert M Hamilton
  • Eur. Heart J..2020 Jun;ehaa383. doi: 10.1093/eurheartj/ehaa383.Epub 2020-06-12.

微粒子の連続的な誘電泳動操作のための傾斜した平面電極を備えたラボ・オン・ア・チップ・プラットフォームの幾何学的パラメータに関するパラメトリック研究

Parametric study on the geometrical parameters of a lab-on-a-chip platform with tilted planar electrodes for continuous dielectrophoretic manipulation of microparticles.
  • Arash Dalili
  • Erfan Taatizadeh
  • Hamed Tahmooressi
  • Nishat Tasnim
  • Pamela Inés Rellstab-Sánchez
  • Matthew Shaunessy
  • Homayoun Najjaran
  • Mina Hoorfar
  • Sci Rep.2020 Jul;10(1):11718. 10.1038/s41598-020-68699-4. doi: 10.1038/s41598-020-68699-4.Epub 2020-07-16.

胸水を伴う中耳炎の小児における肥大したアデノイドにおける血清インスリン様成長因子-1(IGF-1)およびグレリンのアデノイド摘出術の影響について

The effects of adenoidectomy of serum insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children with otitis media with effusion.
  • Beata Żelazowska-Rutkowska
  • Klaudia Jacewicz
  • Edwina Kasprzycka
  • Bożena Skotnicka
  • Bogdan Cylwik
  • Otolaryngol Pol.2020 Mar;74(4):13-17. 01.3001.0014.0223. doi: 10.5604/01.3001.0014.0223.

また、KirBac1.1の開活状態へのゲーティングに伴う構造変化を固体NMRと機能的アッセイにより明らかにした

Conformational changes upon gating of KirBac1.1 into an open-activated state revealed by solid-state NMR and functional assays.
  • Reza Amani
  • Collin G Borcik
  • Nazmul H Khan
  • Derek B Versteeg
  • Maryam Yekefallah
  • Hoa Q Do
  • Heather R Coats
  • Benjamin J Wylie
  • Proc. Natl. Acad. Sci. U.S.A..2020 02;117(6):2938-2947. 1915010117. doi: 10.1073/pnas.1915010117.Epub 2020-01-24.

ウェデロラクトンは、PKAシグナル伝達に依存するNLRP3のSer/Thrリン酸化を促進し、インフルマソーム活性化とピロプトーシスをブロックします

Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis.
  • Hao Pan
  • Yuqing Lin
  • Jianping Dou
  • Zhen Fu
  • Yanqing Yao
  • Shanyu Ye
  • Saixia Zhang
  • Neng Wang
  • Aijun Liu
  • Xican Li
  • Fengxue Zhang
  • Dongfeng Chen
  • Cell Prolif..2020 Jul;:e12868. doi: 10.1111/cpr.12868.Epub 2020-07-12.

Gタンパク質シャペロンとグアニンヌクレオチド交換因子Ric-8AがGαi1に結合した構造

Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1.
  • Levi J McClelland
  • Kaiming Zhang
  • Tung-Chung Mou
  • Jake Johnston
  • Cindee Yates-Hansen
  • Shanshan Li
  • Celestine J Thomas
  • Tzanko I Doukov
  • Sarah Triest
  • Alexandre Wohlkonig
  • Gregory G Tall
  • Jan Steyaert
  • Wah Chiu
  • Stephen R Sprang
  • Nat Commun.2020 02;11(1):1077. 10.1038/s41467-020-14943-4. doi: 10.1038/s41467-020-14943-4.Epub 2020-02-26.

中国式マッサージ、推拿とハーブの組み合わせは、乳腺肥大症患者の臨床症状を改善し、性ホルモンを調節します

Chinese massage, Tui Na, combined with herbs improves clinical symptoms and regulates sex hormones in patients with mammary gland hyperplasia.
  • Dandan Li
  • Cheng Wang
  • Di Ruan
  • Jingjing Li
  • Ning Ji
  • Xinwen Ma
  • Yongtao Li
  • Yujiang Qu
  • Zhijin Xuan
  • Lihua Song
  • Medicine (Baltimore).2020 May;99(21):e20300. 00005792-202005220-00069. doi: 10.1097/MD.0000000000020300.

トキソプラズマ・ゴンドイ中国I遺伝子型Wh6株感染は、GSK3βの活性化を介してタウのリン酸化を誘導し、海馬ニューロンのアポトーシスを引き起こす

Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis.
  • Qing Tao
  • Xianhe Wang
  • Lei Liu
  • Yongsheng Ji
  • Qingli Luo
  • Jian Du
  • Li Yu
  • Jilong Shen
  • Deyong Chu
  • Acta Trop..2020 May;210:105560. S0001-706X(20)30168-6. doi: 10.1016/j.actatropica.2020.105560.Epub 2020-05-31.

N-メチルアデノシン修飾により、ウイルスRNAはRNAセンサーRIG-Iによる認識を逃れることができる

N-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
  • Mijia Lu
  • Zijie Zhang
  • Miaoge Xue
  • Boxuan Simen Zhao
  • Olivia Harder
  • Anzhong Li
  • Xueya Liang
  • Thomas Z Gao
  • Yunsheng Xu
  • Jiyong Zhou
  • Zongdi Feng
  • Stefan Niewiesk
  • Mark E Peeples
  • Chuan He
  • Jianrong Li
  • Nat Microbiol.2020 04;5(4):584-598. 10.1038/s41564-019-0653-9. doi: 10.1038/s41564-019-0653-9.Epub 2020-02-03.

Colitis and Crohn's Foundation (India)：インド初の全国炎症性腸疾患登録簿

Colitis and Crohn's Foundation (India): a first nationwide inflammatory bowel disease registry.
  • Ajit Sood
  • Kirandeep Kaur
  • Ramit Mahajan
  • Vandana Midha
  • Arshdeep Singh
  • Sarit Sharma
  • Amarender Singh Puri
  • Bhabhadev Goswami
  • Devendra Desai
  • C Ganesh Pai
  • Kiran Peddi
  • Mathew Philip
  • Rakesh Kochhar
  • Sandeep Nijhawan
  • Shobna Bhatia
  • N Sridhara Rao
  • Intest Res.2020 Jul;ir.2019.09169. doi: 10.5217/ir.2019.09169.Epub 2020-07-13.

エタノールに対する正常な感受性と迅速な耐性は、ショウジョウバエの楕円体神経細胞におけるGタンパク質受容体キナーゼ2を必要とする

Normal Ethanol Sensitivity and Rapid Tolerance Require the G Protein Receptor Kinase 2 in Ellipsoid Body Neurons in Drosophila.
  • Yuan Yuan Kang
  • Yusuke Wachi
  • Elizabeth Engdorf
  • Emiliano Fumagalli
  • Youyou Wang
  • Jennifer Myers
  • Shebna Massey
  • Antony Greiss
  • Shiyu Xu
  • Gregg Roman
  • Alcohol. Clin. Exp. Res..2020 Jun;doi: 10.1111/acer.14396.Epub 2020-06-23.

寡栄養の北パタゴニア湖における多環芳香族炭化水素の発生源と拡散性の空気-水交換

Sources and diffusive air-water exchange of polycyclic aromatic hydrocarbons in an oligotrophic North-Patagonian lake.
  • Felipe Tucca
  • Thais Luarte
  • Jorge Nimptsch
  • Stefan Woelfl
  • Karla Pozo
  • Gemma Casas
  • Jordi Dachs
  • Ricardo Barra
  • Gustavo Chiang
  • Cristóbal Galbán-Malagón
  • Sci. Total Environ..2020 May;738:139838. S0048-9697(20)33358-1. doi: 10.1016/j.scitotenv.2020.139838.Epub 2020-05-30.

低侵襲橈骨遠位部プレート骨合成術（MIPO）後の低侵襲ハードウェア除去。388症例シリーズのフィージビリティスタディ

Minimally invasive hardware removal after minimally invasive distal radius plate osteosynthesis (MIPO): Feasibility study in a 388 case series.
  • P Luigi Medda
  • A-S Matheron
  • J J Hidalgo Diaz
  • N Maire
  • P Vernet
  • S Facca
  • P Liverneaux
  • Orthop Traumatol Surg Res.2017 02;103(1):85-87. S1877-0568(16)30227-4. doi: 10.1016/j.otsr.2016.10.015.Epub 2016-12-05.

一次選択的全人工股関節置換術後の術後せん妄の発生率と危険因子：レトロスペクティブな全国の入院患者サンプルデータベース研究

Incidence and risk factors associated with postoperative delirium following primary elective total hip arthroplasty: a retrospective nationwide inpatient sample database study.
  • Qinfeng Yang
  • Jian Wang
  • Xusheng Huang
  • Yichuan Xu
  • Yang Zhang
  • BMC Psychiatry.2020 Jul;20(1):343. 10.1186/s12888-020-02742-6. doi: 10.1186/s12888-020-02742-6.Epub 2020-07-01.

イミダゾリン受容体リガンドMCR5による治療後の分子変化を伴うSAMP8マウスモデルにおけるBPSD様表現型と認知機能低下の改善

Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I-Imidazoline Receptor Ligand MCR5.
  • Foteini Vasilopoulou
  • Andrea Bagan
  • Sergio Rodriguez-Arevalo
  • Carmen Escolano
  • Christian Griñán-Ferré
  • Mercè Pallàs
  • Pharmaceutics.2020 May;12(5). E475. doi: 10.3390/pharmaceutics12050475.Epub 2020-05-23.

酸性スフィンゴミエリン酵素欠乏症（ASM）治療のためのオリプダーゼアルファ：30ヶ月間治療した成人における安全性と有効性

Olipudase alfa for treatment of acid sphingomyelinase deficiency (ASMD): safety and efficacy in adults treated for 30 months.
  • Melissa P Wasserstein
  • George A Diaz
  • Robin H Lachmann
  • Marie-Hélène Jouvin
  • Indrani Nandy
  • Allena J Ji
  • Ana Cristina Puga
  • J. Inherit. Metab. Dis..2018 09;41(5):829-838. 10.1007/s10545-017-0123-6. doi: 10.1007/s10545-017-0123-6.Epub 2018-01-05.

アフリカ・マラガシーの3つの農業地域におけるげっ歯類の影響と、生態学に基づいたげっ歯類管理に関する文化的認識の比較評価

Comparative assessment on rodent impacts and cultural perceptions of ecologically based rodent management in 3 Afro-Malagasy farming regions.
  • Natasha L Constant
  • Lourens H Swanepoel
  • Samual T Williams
  • Voahangy Soarimalala
  • Steven M Goodman
  • Apia T Massawe
  • Loth S Mulungu
  • Rhodes H Makundi
  • Mashaka E Mdangi
  • Peter J Taylor
  • Steven R Belmain
  • Integr Zool.2020 Apr;doi: 10.1111/1749-4877.12447.Epub 2020-04-29.

ボスニア・ヘルツェゴビナにおけるCOVID-19の蔓延防止対策のモニタリングのための時空間データの可視化

Spatio-temporal data visualization for monitoring of control measures in the prevention of the spread of COVID-19 in Bosnia and Herzegovina.
  • Mirza Ponjavić
  • Almir Karabegović
  • Elvir Ferhatbegović
  • Emin Tahirović
  • Selma Uzunović
  • Maja Travar
  • Aida Pilav
  • Maida Mulić
  • Sead Karakaš
  • Nermin Avdić
  • Zarina Mulabdić
  • Goran Pavić
  • Medina Bičo
  • Ivan Vasilj
  • Diana Mamić
  • Mirsada Hukić
  • Med Glas (Zenica).2020 Aug;17(2). doi: 10.17392/1215-20.Epub 2020-08-01.

サハラ以南の国、コートジボワールにおける抗風疹IgG抗体の化学発光に基づく検出のための2つの（02）プラットフォームの評価

Evaluation of two (02) platforms for chemiluminescence-based detection of anti-rubella IgG antibodies in a sub-Saharan country, Côte d'Ivoire.
  • Bamory Dembele
  • Aimé Cézaire Adiko
  • Roseline Affi-Aboli
  • Rodrigue Denis Kouame
  • Kady Mabity Bamba
  • Jea-Luc Adjoumani
  • Tano Matthieu Kabran
  • André Inwoley
  • J Immunoassay Immunochem.2020 Jun;:1-11. doi: 10.1080/15321819.2020.1786398.Epub 2020-06-30.

チリ以外の国でもスポロトリックスは流通しているのか？

Is Sporothrix chilensis circulating outside Chile?
  • Carlos Alberto Tiburcio Valeriano
  • Reginaldo Gonçalves de Lima-Neto
  • Cícero Pinheiro Inácio
  • Vanessa Brito de Souza Rabello
  • Ertênia Paiva Oliveira
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アシルコエンザイムA結合タンパク質（ACBP）／ジアゼパム結合阻害剤（DBI）の代謝・精神作用

Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI).
  • Adrien Joseph
  • Stéphanie Moriceau
  • Valentina Sica
  • Gerasimos Anagnostopoulos
  • Jonathan Pol
  • Isabelle Martins
  • Antoine Lafarge
  • Maria Chiara Maiuri
  • Marion Leboyer
  • Josephine Loftus
  • Frank Bellivier
  • Raoul Belzeaux
  • Fabrice Berna
  • Bruno Etain
  • Delphine Capdevielle
  • Philippe Courtet
  • Caroline Dubertret
  • Julien Dubreucq
  • D' Amato Thierry
  • Guillaume Fond
  • Sebastien Gard
  • Pierre-Michel Llorca
  • Jasmina Mallet
  • David Misdrahi
  • Emilie Olié
  • Christine Passerieux
  • Mircea Polosan
  • Paul Roux
  • Ludovic Samalin
  • Franck Schürhoff
  • Raymond Schwan
  • Christophe Magnan
  • Franck Oury
  • José M Bravo-San Pedro
  • Guido Kroemer
  • Cell Death Dis.2020 Jul;11(7):502. 10.1038/s41419-020-2716-5. doi: 10.1038/s41419-020-2716-5.Epub 2020-07-06.

TNF-αを介したカスパーゼ8の活性化は、成人心室筋細胞において活性酸素の産生とTRPM2の活性化を誘導することが明らかになった

TNF-α-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes.
  • Stéphanie Roberge
  • Julien Roussel
  • Daniel C Andersson
  • Albano C Meli
  • Bastien Vidal
  • Florence Blandel
  • Johanna T Lanner
  • Jean-Yves Le Guennec
  • Abram Katz
  • Håkan Westerblad
  • Alain Lacampagne
  • Jérémy Fauconnier
  • Cardiovasc. Res..2014 Jul;103(1):90-9. cvu112. doi: 10.1093/cvr/cvu112.Epub 2014-05-06.

肺がん検診のバイオマーカーとしての循環腫瘍細胞：前向きコホート研究

Circulating tumour cells as a potential biomarker for lung cancer screening: a prospective cohort study.
  • Charles-Hugo Marquette
  • Jacques Boutros
  • Jonathan Benzaquen
  • Marion Ferreira
  • Jean Pastre
  • Christophe Pison
  • Bernard Padovani
  • Faiza Bettayeb
  • Vincent Fallet
  • Nicolas Guibert
  • Damien Basille
  • Marius Ilie
  • Véronique Hofman
  • Paul Hofman
  • Lancet Respir Med.2020 Jul;8(7):709-716. S2213-2600(20)30081-3. doi: 10.1016/S2213-2600(20)30081-3.

中心性早期非小細胞肺癌に対する変調型トリコバルト60遠隔療法とリニアアクセラレータを用いた定位放射線治療との治療計画の比較

A treatment planning comparison between modulated tri-cobalt-60 teletherapy and linear accelerator-based stereotactic body radiotherapy for central early-stage non-small cell lung cancer.
  • Catherine Merna
  • Jean-Claude M Rwigema
  • Minsong Cao
  • Pin-Chieh Wang
  • Amar U Kishan
  • Argin Michailian
  • James Lamb
  • Ke Sheng
  • Nzhde Agazaryan
  • Daniel A Low
  • Patrick Kupelian
  • Michael L Steinberg
  • Percy Lee
  • Med Dosim.2016;41(1):87-91. S0958-3947(15)00108-9. doi: 10.1016/j.meddos.2015.09.002.Epub 2016-01-02.

夜間性多尿患者の遅波睡眠時間改善に対するデスモプレッシン経口投与の効果に関する脳波検査に基づく調査（DISTINCT試験）の根拠、デザイン、方法：単群、非盲検、単一割り付け試験のプロトコール

Rationale, design, and methods of electroencephalography-based investigation of the effects of oral desmopressin on improving slow-wave sleep time in nocturnal polyuria patients (the DISTINCT study): protocol for a single-arm, open-label, single-assignment trial.
  • Kazumasa Torimoto
  • Makito Miyake
  • Yasushi Nakai
  • Katsuya Aoki
  • Nobumichi Tanaka
  • Kiyohide Fujimoto
  • BMC Urol.2020 Jul;20(1):96. 10.1186/s12894-020-00668-5. doi: 10.1186/s12894-020-00668-5.Epub 2020-07-11.

クロルピリホスによるヒト乳癌細胞株の細胞増殖は、エストロゲンおよびアリール炭化水素受容体とKIAA1363酵素を介して24時間および14日間の曝露後に異なります

Chlorpyrifos-induced cell proliferation in human breast cancer cell lines differentially mediated by estrogen and aryl hydrocarbon receptors and KIAA1363 enzyme after 24 h and 14 days exposure.
  • Paula Moyano
  • Jimena García
  • José Manuel García
  • Adela Pelayo
  • Pilar Muñoz-Calero
  • María Teresa Frejo
  • Maria Jose Anadon
  • Margarita Lobo
  • Javier Del Pino
  • Chemosphere.2020 Jul;251:126426. S0045-6535(20)30619-6. doi: 10.1016/j.chemosphere.2020.126426.Epub 2020-03-06.

プロテオームとトランスクリプトームにより、クレマチスの耐熱性におけるヒートショックタンパク質と抗酸化システムの関与が明らかになった

Proteome and transcriptome reveal the involvement of heat shock proteins and antioxidant system in thermotolerance of Clematis florida.
  • Changhua Jiang
  • Yuke Bi
  • Jianbin Mo
  • Ruyao Zhang
  • Mingnan Qu
  • Shucheng Feng
  • Jemaa Essemine
  • Sci Rep.2020 Jun;10(1):8883. 10.1038/s41598-020-65699-2. doi: 10.1038/s41598-020-65699-2.Epub 2020-06-01.

対人栄養キャンペーンと母親の知識と幼児期の摂食習慣：インドネシア農村部の母親からのケーススタディ

An interpersonal nutrition campaign and maternal knowledge and childhood feeding practices: a case study from mothers in rural Indonesia.
  • Cecily Starkweather
  • Ayla Guarino
  • Natalie Bennion
  • Malynne Cottam
  • Josie McGhie
  • Kirk A Dearden
  • Otte Santika
  • Hafizah Jusril
  • Cougar Hall
  • Benjamin T Crookston
  • Mary Linehan
  • Scott Torres
  • Cudjoe Bennett
  • Joshua H West
  • Arch Public Health.2020;78:62. 444. doi: 10.1186/s13690-020-00444-9.Epub 2020-07-09.

トロカールとセルディンガー手技を用いたインターベンショナルラジオロジー画像ガイド下経皮的上腹式膀胱切開術。結果と合併症の比較分析

Interventional Radiology Image-Guided Suprapubic Cystostomy Using Trocar versus Seldinger Technique: A Comparative Analysis of Outcomes and Complications.
  • Dustin G Roberts
  • Ricky B Patel
  • Scott J Genshaft
  • Siddharth A Padia
  • Justin P McWilliams
  • John M Moriarty
  • Ravi N Srinivasa
  • Urology.2020 May;S0090-4295(20)30559-8. doi: 10.1016/j.urology.2020.05.015.Epub 2020-05-20.

治療後に歯周炎を発症した歯の根尖部のコーンビームCTおよびマイクロコンピュータ断層撮影による評価

Cone-beam computed tomographic and micro-computed tomographic evaluations of the root apexes of teeth with posttreatment apical periodontitis.
  • Paula A Villa-Machado
  • Diana M Restrepo-Patiño
  • Juliana P Calvo-Trejos
  • Felipe A Restrepo-Restrepo
  • Sergio I Tobón-Arroyave
  • José C Provenzano
  • José F Siqueira
  • Flávio R F Alves
  • J Endod.2020 Jul;S0099-2399(20)30496-9. doi: 10.1016/j.joen.2020.07.009.Epub 2020-07-16.

2 型糖尿病患者における地中海式食事および/または薬物治療のアドヒアランスが血糖コントロールに与える影響。DM2-CUMCYL試験

Impact of adherence to Mediterranean diet and/or drug treatment on glycaemic control in type 2 diabetes mellitus patients: DM2-CUMCYL study.
  • María Sonsoles Sánchez-Hernández
  • María Cristina Rodríguez-Caldero
  • María Pilar Martín-Pérez
  • Jose Joaquín Mira-Solves
  • Julian Vitaller-Burillo
  • María Concepción Carratalá-Munuera
  • Prim Care Diabetes.2020 Jul;S1751-9918(20)30220-5. doi: 10.1016/j.pcd.2020.06.008.Epub 2020-07-13.

超保存的アクセスキャビティと最小根管テーパが抜歯した下顎臼歯の根管形成能力とその耐骨折性に与える影響についての実験的研究

A laboratory study of the impact of ultraconservative access cavities and minimal root canal tapers on the ability to shape canals in extracted mandibular molars and their fracture resistance.
  • C M Augusto
  • A F A Barbosa
  • C C Guimarães
  • C O Lima
  • C M Ferreira
  • L M Sassone
  • E J N L Silva
  • Int Endod J.2020 Jul;doi: 10.1111/iej.13369.Epub 2020-07-19.

カドミウムと鉛で汚染された圃場のファイトレメディエーションを促進するために、内生植物を接種したSedum alfrediiとファバ豆の間作を実施した

Fava bean intercropping with Sedum alfredii inoculated with endophytes enhances phytoremediation of cadmium and lead co-contaminated field.
  • Lin Tang
  • Yasir Hamid
  • Afsheen Zehra
  • Zulfiqar Ali Sahito
  • Zhenli He
  • Wolde Tefera Beri
  • Muhammad Bilal Khan
  • Xiaoe Yang
  • Environ. Pollut..2020 May;265(Pt A):114861. S0269-7491(20)32450-7. doi: 10.1016/j.envpol.2020.114861.Epub 2020-05-29.

ISSAID/EMQN 次世代シークエンシング時代における単発性自己炎症性疾患の遺伝学的診断のためのベスト・プラクティス・ガイドライン（Best Practice Guidelines for the Genetic Diagnosis of Monogenic Autoinflammatory Diseases in the Next-Generation Sequencing Era

ISSAID/EMQN Best Practice Guidelines for the Genetic Diagnosis of Monogenic Autoinflammatory Diseases in the Next-Generation Sequencing Era.
  • Yael Shinar
  • Isabella Ceccherini
  • Dorota Rowczenio
  • Ivona Aksentijevich
  • Juan Arostegui
  • Eldad Ben-Chétrit
  • Guilaine Boursier
  • Marco Gattorno
  • Hasmik Hayrapetyan
  • Hiroaki Ida
  • Nobuo Kanazawa
  • Helen J Lachmann
  • Anna Mensa-Vilaro
  • Ryuta Nishikomori
  • Christian Oberkanins
  • Laura Obici
  • Osamu Ohara
  • Seza Ozen
  • Tamara Sarkisian
  • Katie Sheils
  • Nicola Wolstenholme
  • Evelien Zonneveld-Huijssoon
  • Marielle E van Gijn
  • Isabelle Touitou
  • Clin. Chem..2020 Apr;66(4):525-536. 5807902. doi: 10.1093/clinchem/hvaa024.

オーストラリアの公衆衛生システムにおける単発性疾患が疑われる重症の乳幼児および小児における超高速エクソームシークエンシングの可能性

Feasibility of Ultra-Rapid Exome Sequencing in Critically Ill Infants and Children With Suspected Monogenic Conditions in the Australian Public Health Care System.
  • Sebastian Lunke
  • Stefanie Eggers
  • Meredith Wilson
  • Chirag Patel
  • Christopher P Barnett
  • Jason Pinner
  • Sarah A Sandaradura
  • Michael F Buckley
  • Emma I Krzesinski
  • Michelle G de Silva
  • Gemma R Brett
  • Kirsten Boggs
  • David Mowat
  • Edwin P Kirk
  • Lesley C Adès
  • Lauren S Akesson
  • David J Amor
  • Samantha Ayres
  • Anne Baxendale
  • Sarah Borrie
  • Alessandra Bray
  • Natasha J Brown
  • Cheng Yee Chan
  • Belinda Chong
  • Corrina Cliffe
  • Martin B Delatycki
  • Matthew Edwards
  • George Elakis
  • Michael C Fahey
  • Andrew Fennell
  • Lindsay Fowles
  • Lyndon Gallacher
  • Megan Higgins
  • Katherine B Howell
  • Lauren Hunt
  • Matthew F Hunter
  • Kristi J Jones
  • Sarah King
  • Smitha Kumble
  • Sarah Lang
  • Maelle Le Moing
  • Alan Ma
  • Dean Phelan
  • Michael C J Quinn
  • Anna Richards
  • Christopher M Richmond
  • Jessica Riseley
  • Jonathan Rodgers
  • Rani Sachdev
  • Simon Sadedin
  • Luregn J Schlapbach
  • Janine Smith
  • Amanda Springer
  • Natalie B Tan
  • Tiong Y Tan
  • Suzanna L Temple
  • Christiane Theda
  • Anand Vasudevan
  • Susan M White
  • Alison Yeung
  • Ying Zhu
  • Melissa Martyn
  • Stephanie Best
  • Tony Roscioli
  • John Christodoulou
  • Zornitza Stark
  • JAMA.2020 06;323(24):2503-2511. 2767327. doi: 10.1001/jama.2020.7671.

部分脱窒と脱窒リン除去の複合プロセス（PD-DPR）による高硝酸塩・市営排水からの安定した亜硝酸塩の蓄積とリンの除去

[Stable Nitrite Accumulation and Phosphorus Removal from High-nitrate and Municipal Wastewaters in a Combined Process of Partial Denitrification and Denitrifying Phosphorus Removal (PD-DPR)].
  • Qiu-Ying Wang
  • De-Shuang Yu
  • Ji Zhao
  • Xiao-Xia Wang
  • Meng-Fei Yuan
  • Xiu-Zhen Gong
  • Guang-Yu Chu
  • Tong-Hui He
  • Huan Jing Ke Xue.2020 Mar;41(3):1384-1392. doi: 10.13227/j.hjkx.201909251.

1分子リアルタイムシークエンシング技術（PacBio）によるスプライシング欠陥の同定と特性評価

Identification and Characterization of Splicing Defects by Single-Molecule Real-Time Sequencing Technology (PacBio).
  • Marco Savarese
  • Talha Qureshi
  • Annalaura Torella
  • Pia Laine
  • Teresa Giugliano
  • Per Harald Jonson
  • Mridul Johari
  • Lars Paulin
  • Giulio Piluso
  • Petri Auvinen
  • Vincenzo Nigro
  • Bjarne Udd
  • Peter Hackman
  • J Neuromuscul Dis.2020 Jun;JND200523. doi: 10.3233/JND-200523.Epub 2020-06-22.

ナノキナクリンは、ADAM-17を介してNECTIN-4をダウンレギュレーションすることで、5-FU耐性子宮頸がん幹細胞を感作した

Nanoquinacrine sensitizes 5-FU-resistant cervical cancer stem-like cells by down-regulating Nectin-4 via ADAM-17 mediated NOTCH deregulation.
  • Anmada Nayak
  • Sarita Das
  • Deepika Nayak
  • Chinmayee Sethy
  • Satya Narayan
  • Chanakya Nath Kundu
  • Cell Oncol (Dordr).2019 Apr;42(2):157-171. 10.1007/s13402-018-0417-1. doi: 10.1007/s13402-018-0417-1.Epub 2019-01-03.

2型糖尿病におけるインスリン誘発性皮膚脂肪肥大症：南イタリアにおける多施設地域調査

Insulin-Induced Skin Lipohypertrophy in Type 2 Diabetes: a Multicenter Regional Survey in Southern Italy.
  • Sandro Gentile
  • Giuseppina Guarino
  • Teresa Della Corte
  • Giampiero Marino
  • Alessandra Fusco
  • Gerardo Corigliano
  • Sara Colarusso
  • Marco Piscopo
  • Maria Rosaria Improta
  • Marco Corigliano
  • Emilia MartedÌ
  • Domenica Oliva
  • Viviana Russo
  • Rosa Simonetti
  • Ersilia Satta
  • Carmine Romano
  • Carmelo Alfarone
  • Antonio Vetrano
  • Carmine Martino
  • Clelia Lamberti
  • Agostino Vecchiato
  • Giuseppe Cozzolino
  • Clementina Brancario
  • Felice Strollo
  • Diabetes Ther.2020 Jul;10.1007/s13300-020-00876-0. doi: 10.1007/s13300-020-00876-0.Epub 2020-07-18.

胃がん患者の健康関連QOLと健康状態の有用性スコア。中国における多施設横断調査

Health-related quality of life and health utility score of patients with gastric cancer: A multi-centre cross-sectional survey in China.
  • Ruyi Xia
  • Hongmei Zeng
  • Qian Liu
  • Shuzheng Liu
  • Zhiyi Zhang
  • Yuqin Liu
  • Guizhou Guo
  • Guohui Song
  • Yigong Zhu
  • Xianghong Wu
  • Bingbing Song
  • Xianzhen Liao
  • Yanfang Chen
  • Wenqiang Wei
  • Gang Chen
  • Wanqing Chen
  • Guihua Zhuang
  • Eur J Cancer Care (Engl).2020 Jun;:e13283. doi: 10.1111/ecc.13283.Epub 2020-06-29.

神経芽腫患者におけるメタイドベンジルグアニジン（MIBG）スキャンのコンピュータ支援キュリースコアリング．

Computer-assisted Curie scoring for metaiodobenzylguanidine (MIBG) scans in patients with neuroblastoma.
  • Elizabeth A Sokol
  • Roger Engelmann
  • Wenjun Kang
  • Navin Pinto
  • Adam Starkey
  • Hollie Lai
  • Helen Nadel
  • Barry L Shulkin
  • Yonglin Pu
  • Daniel Appelbaum
  • Gregory A Yanik
  • Susan L Cohn
  • Samuel G Armato
  • Samuel Volchenboum
  • Pediatr Blood Cancer.2018 12;65(12):e27417. doi: 10.1002/pbc.27417.Epub 2018-09-10.

mRNAアイソフォームを網羅的に同定することで、網膜の発達や疾患に関与する神経細胞表面分子の多様性が明らかになります

Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease.
  • Thomas A Ray
  • Kelly Cochran
  • Chris Kozlowski
  • Jingjing Wang
  • Graham Alexander
  • Martha A Cady
  • William J Spencer
  • Philip A Ruzycki
  • Brian S Clark
  • Annelies Laeremans
  • Ming-Xiao He
  • Xiaoming Wang
  • Emily Park
  • Ying Hao
  • Alessandro Iannaccone
  • Gary Hu
  • Olivier Fedrigo
  • Nikolai P Skiba
  • Vadim Y Arshavsky
  • Jeremy N Kay
  • Nat Commun.2020 Jul;11(1):3328. 10.1038/s41467-020-17009-7. doi: 10.1038/s41467-020-17009-7.Epub 2020-07-03.

アンジオテンシンIIは実験糖尿病ラットにおける高度糖化最終産物受容体の心筋発現、単球/マクロファージ浸潤および循環エンドセリン-1の増加を誘導した

Angiotensin II Induces Increased Myocardial Expression of Receptor for Advanced Glycation End Products, Monocyte/Macrophage Infiltration and Circulating Endothelin-1 in Rats With Experimental Diabetes.
  • Nelson Muñoz
  • Adriana Pedreañez
  • Jesús Mosquera
  • Can J Diabetes.2020 Apr;S1499-2671(20)30083-6. doi: 10.1016/j.jcjd.2020.03.010.Epub 2020-04-09.

集団ベースのサンプルにおける高トリグリセリドと動脈硬化との関連。Kardiovize Brno 2030調査

Associations between high triglycerides and arterial stiffness in a population-based sample: Kardiovize Brno 2030 study.
  • Iuliia Pavlovska
  • Sarka Kunzova
  • Juraj Jakubik
  • Jana Hruskova
  • Maria Skladana
  • Irma Magaly Rivas-Serna
  • Jose R Medina-Inojosa
  • Francisco Lopez-Jimenez
  • Robert Vysoky
  • Yonas E Geda
  • Gorazd B Stokin
  • Juan P González-Rivas
  • Lipids Health Dis.2020 Jul;19(1):170. 10.1186/s12944-020-01345-0. doi: 10.1186/s12944-020-01345-0.Epub 2020-07-15.

リウマチ性疾患患者における避妊習慣に関する質問紙ベースの研究では、年齢をマッチさせた健康な対照者との間に有意な差は見られなかった

A questionnaire-based study on contraceptive practice in patients with rheumatic disease found no significant difference in age-matched healthy controls.
  • Andrea Pluma
  • Mihaela C Micu
  • Antonio Julià
  • Sara Marsal
  • Frauke Förger
  • Monika Østensen
  • Rheumatol. Int..2020 May;10.1007/s00296-020-04598-1. doi: 10.1007/s00296-020-04598-1.Epub 2020-05-18.

非侵襲的呼吸補助を受けた超低出生体重児の臥位対臥位の間の SpO ヒストグラムで評価された酸素化不安定性

Oxygenation Instability Assessed by SpO Histograms during Supine vs. Prone Position in Very Low Birthweight Infants Receiving Non-invasive Respiratory Support.
  • Adi Miller-Barmak
  • Arieh Riskin
  • Ori Hochwald
  • Julie Haddad
  • Gil Dinur
  • Rita Vortman
  • Amir Kugelman
  • Liron Borenstein-Levin
  • J. Pediatr..2020 Jun;S0022-3476(20)30819-2. doi: 10.1016/j.jpeds.2020.06.066.Epub 2020-06-29.

アフリカにおける成人1型糖尿病患者の管理。国際糖尿病管理実践研究（Wave 7）に参加したアフリカ12カ国のポストホックコホート分析

Management of adult patients with type 1 diabetes mellitus in Africa: A post-hoc cohort analysis of 12 African countries participating in the International Diabetes Management Practices Study (Wave 7).
  • Jean Claude Mbanya
  • Poobalan Naidoo
  • Babatope Ayodeji Kolawole
  • Ellina Tsymbal
  • Alicia McMaster
  • Sumanth Karamchand
  • Hilton Kaplan
  • Virendra Rambiritch
  • Mark Cotton
  • Rachid Malek
  • Lawrence Allen Distiller
  • Rory Forseth Leisegang
  • Medicine (Baltimore).2020 Jun;99(25):e20553. 00005792-202006190-00024. doi: 10.1097/MD.0000000000020553.

HER2陽性乳がんにおけるアド-トラスツズマブ・エムタンシン（T-DM1）のmRNA発現と応答性について

mRNA Expression and Response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-Positive Breast Cancer.
  • Gaia Griguolo
  • Fara Brasó-Maristany
  • Blanca González-Farré
  • Tomás Pascual
  • Núria Chic
  • Tamara Saurí
  • Ronald Kates
  • Oleg Gluz
  • Débora Martínez
  • Laia Paré
  • Vassilena Tsvetkova
  • David Pesantez
  • Maria Vidal
  • Barbara Adamo
  • Montserrat Muñoz
  • Patricia Galván
  • Laura Barberá
  • Miriam Cuatrecasas
  • Mathias Christgen
  • Hans Kreipe
  • Inés Monge-Escartín
  • Patricia Villagrasa
  • Dolors Soy
  • Tommaso Giarratano
  • Maria Vittoria Dieci
  • Pierfranco Conte
  • Nadia Harbeck
  • Valentina Guarneri
  • Aleix Prat
  • Cancers (Basel).2020 Jul;12(7). E1902. doi: 10.3390/cancers12071902.Epub 2020-07-14.

感染に対する宿主応答を研究するためのヒト卵管上皮細胞培養モデル

A Human Fallopian Tube Epithelial Cell Culture Model to Study Host Responses to Infection.
  • Bryan E McQueen
  • Amy Kiatthanapaiboon
  • M Leslie Fulcher
  • Mariam Lam
  • Kate Patton
  • Emily Powell
  • Avinash Kollipara
  • Victoria Madden
  • Robert J Suchland
  • Priscilla Wyrick
  • Catherine M O'Connell
  • Boris Reidel
  • Mehmet Kesimer
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  • Toni Darville
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  • Infect. Immun..2020 Jun;IAI.00105-20. doi: 10.1128/IAI.00105-20.Epub 2020-06-29.

メルト造粒連続処理技術を用いて調製した塩酸メトホルミンとリン酸シタグリプチンの合剤

Metformin Hydrochloride and Sitagliptin Phosphate Fixed-Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology.
  • Jeremiah F Kelleher
  • Atif M Madi
  • Gareth C Gilvary
  • Y W Tian
  • Shu Li
  • Ammar Almajaan
  • Zoe S Loys
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  • Gavin P Andrews
  • Anne Marie Healy
  • AAPS PharmSciTech.2019 Dec;21(1):23. 10.1208/s12249-019-1553-2. doi: 10.1208/s12249-019-1553-2.Epub 2019-12-12.

メラトニンとカルシウムが塩分ストレス下のDracocephalum kotschyiにおけるロスマリン酸、ルテオリン、アピゲニンの産生を調節することを明らかにした

Melatonin and calcium modulate the production of rosmarinic acid, luteolin, and apigenin in Dracocephalum kotschyi under salinity stress.
  • Farinaz Vafadar
  • Rayhaneh Amooaghaie
  • Parviz Ehsanzadeh
  • Mustafa Ghanadian
  • Majid Talebi
  • Faezeh Ghanati
  • Phytochemistry.2020 Jun;177:112422. S0031-9422(20)30003-0. doi: 10.1016/j.phytochem.2020.112422.Epub 2020-06-25.

腎移植レシピエントのリバビリンに耐性のある慢性ウイルス性E型肝炎では，ペギル化インターフェロンの使用が検討される可能性がある．

Pegylated interferon may be considered in chronic viral hepatitis E resistant to ribavirin in kidney transplant recipients.
  • I Ollivier-Hourmand
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  • A Lecouf
  • M Allaire
  • T T N Nguyen
  • C Lier
  • T Dao
  • BMC Infect. Dis..2020 Jul;20(1):522. 10.1186/s12879-020-05212-2. doi: 10.1186/s12879-020-05212-2.Epub 2020-07-16.

COVID-19入院患者における呼吸不全、集中治療室入院、死亡の危険因子としての肥満はどの程度重要なのでしょうか？イタリアの単一施設からの結果

How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? Results from a single Italian centre.
  • Matteo Rottoli
  • Paolo Bernante
  • Angela Belvedere
  • Francesca Balsamo
  • Silvia Garelli
  • Maddalena Giannella
  • Alessandra Cascavilla
  • Sara Tedeschi
  • Stefano Ianniruberto
  • Elena Rosselli Del Turco
  • Tommaso Tonetti
  • Vito Marco Ranieri
  • Gilberto Poggioli
  • Lamberto Manzoli
  • Uberto Pagotto
  • Pierluigi Viale
  • Michele Bartoletti
  • Eur. J. Endocrinol..2020 Jul;EJE-20-0541.R2. doi: 10.1530/EJE-20-0541.Epub 2020-07-01.

フィラデルフィア染色体陰性急性リンパ芽球性白血病患者で化学療法を受けているが、同種造血幹細胞移植を受けていない患者では、単染色体核型は予後不良と関連している

Monosomal karyotype is associated with poor outcomes in patients with Philadelphia chromosome-negative acute lymphoblastic leukemia receiving chemotherapy but not allogeneic hematopoietic stem cell transplantation.
  • Zongru Li
  • Yueyun Lai
  • Xiaohui Zhang
  • Lanping Xu
  • Kaiyan Liu
  • Yu Wang
  • Chenhua Yan
  • Hao Jiang
  • Xiaojun Huang
  • Qian Jiang
  • Ann. Hematol..2020 Aug;99(8):1833-1843. 10.1007/s00277-020-04155-7. doi: 10.1007/s00277-020-04155-7.Epub 2020-06-23.

重度の精神障害における総コレステロールと攻撃性、衝動性の関係を紐解く

Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders.
  • Gabriela Hjell
  • Lynn Mørch-Johnsen
  • René Holst
  • Natalia Tesli
  • Christina Bell
  • Synve Hoffart Lunding
  • Linn Rødevand
  • Maren Caroline Frogner Werner
  • Ingrid Melle
  • Ole Andreas Andreassen
  • Trine Vik Lagerberg
  • Nils Eiel Steen
  • Unn Kristin Haukvik
  • Brain Behav.2020 Jul;:e01751. doi: 10.1002/brb3.1751.Epub 2020-07-17.

顔の表情の時間的変化は病棟で病状悪化のリスクがある患者を特定するのに役立つか？Visual Early Warning Score Studyのポストホック分析

Do Temporal Changes in Facial Expressions Help Identify Patients at Risk of Deterioration in Hospital Wards? A Post Hoc Analysis of the Visual Early Warning Score Study.
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  • Dawn Archer
  • Mervyn Singer
  • Marcos Rodrigues
  • Alex Shenfield
  • Jeronimo Moreno-Cuesta
  • Crit Care Explor.2020 May;2(5):e0115. doi: 10.1097/CCE.0000000000000115.Epub 2020-05-06.

母体のトリプトファン補給は、母体の慢性腎臓病によってプログラムされた高血圧に対する成人ラット子孫を保護します。トリプトファン代謝マイクロバイオームとアリール炭化水素受容体の含意

Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor.
  • Chien-Ning Hsu
  • I-Chun Lin
  • Hong-Ren Yu
  • Li-Tung Huang
  • Mao-Meng Tiao
  • You-Lin Tain
  • Int J Mol Sci.2020 Jun;21(12). E4552. doi: 10.3390/ijms21124552.Epub 2020-06-26.

イタリア、南チロルのヤギ集団におけるカプリン関節炎脳炎ウイルスの駆除：2016-2017年キャンペーン中のテーリング現象の解析

Eradication of caprine arthritis encephalitis virus in the goat population of South Tyrol, Italy: analysis of the tailing phenomenon during the 2016-2017 campaign.
  • Stefano Nardelli
  • Astrid Bettini
  • Katia Capello
  • Giuseppe Bertoni
  • Alexander Tavella
  • J. Vet. Diagn. Invest..2020 Jun;:1040638720934055. doi: 10.1177/1040638720934055.Epub 2020-06-18.

また、Pinellia ternata の短期熱ストレス応答のトランスクリプトーム解析により、スペルミジンとメラトニンによる耐熱性の改善について新たな知見を得ることができた

Transcriptomic analysis of short-term heat stress response in Pinellia ternata provided novel insights into the improved thermotolerance by spermidine and melatonin.
  • Guangjing Ma
  • Meide Zhang
  • Jilei Xu
  • Wuxian Zhou
  • Liwen Cao
  • Ecotoxicol. Environ. Saf..2020 Jun;202:110877. S0147-6513(20)30716-8. doi: 10.1016/j.ecoenv.2020.110877.Epub 2020-06-20.

細胞送達のための生体材料インプラント：臨床的、術中の超音波エラストグラフィにより、脊髄損傷におけるハイドロゲル合成のための「目標」剛性が提供される

Stiffness-matched biomaterial implants for cell delivery: clinical, intraoperative ultrasound elastography provides a 'target' stiffness for hydrogel synthesis in spinal cord injury.
  • Jon Prager
  • Christopher F Adams
  • Alexander M Delaney
  • Guillaume Chanoit
  • John F Tarlton
  • Liang-Fong Wong
  • Divya M Chari
  • Nicolas Granger
  • J Tissue Eng.2020 Jan-Dec;11:2041731420934806. 10.1177_2041731420934806. doi: 10.1177/2041731420934806.Epub 2020-07-02.

トルコの下痢性子牛、子羊、ヤギの子供におけるクリプトスポリジウム感染症の遺伝子型とサブタイプの分子検出

Molecular detection of genotypes and subtypes of Cryptosporidium infection in diarrheic calves, lambs, and goat kids from Turkey.
  • Mohammad Hazzaz Bin Kabir
  • Onur Ceylan
  • Ceylan Ceylan
  • Ayman Ahmed Shehata
  • Hironori Bando
  • Mohamed Ibrahim Essa
  • Xuenan Xuan
  • Ferda Sevinc
  • Kentaro Kato
  • Parasitol. Int..2020 Jun;79:102163. S1383-5769(20)30113-6. doi: 10.1016/j.parint.2020.102163.Epub 2020-06-24.

成人脊椎変形症に対する外科的治療を受けた患者の術後胃食道逆流症の改善に影響を与える主要なX線画像パラメータと最低2年間のフォローアップ

Key Radiographic Parameters That Influence the Improvement of Postoperative Gastroesophageal Reflux Disease in Patients Treated Surgically for Adult Spinal Deformity With a Minimum 2-Year Follow-up.
  • Tetsuro Ohba
  • Shigeto Ebata
  • Hiroki Oba
  • Kotaro Oda
  • Nobuki Tanaka
  • Kenuke Koyama
  • Hirotaka Haro
  • Spine.2020 Aug;45(15):E943-E949. 00007632-202008010-00013. doi: 10.1097/BRS.0000000000003459.

気管支内超音波ガイド下経気管支針吸引に対する赤眼球対赤眼球上ジェット換気。無作為化比較試験

Infraglottic versus supraglottic jet-ventilation for endobronchial ultrasound-guided transbronchial needle aspiration: A randomised controlled trial.
  • Maria Anwar
  • Robert Fritze
  • Eva Base
  • Thomas Wasserscheid
  • Nadja Wolfram
  • Herbert Koinig
  • Klaus Hackner
  • Christopher Lambers
  • Thomas Schweiger
  • Peter Errhalt
  • Mir A Hoda
  • Eur J Anaesthesiol.2020 Jun;doi: 10.1097/EJA.0000000000001220.Epub 2020-06-08.

フルフェナム酸との併用投与による転移性乳癌および肝細胞癌に対するソラフェニブメソポーラスシリカナノマトリクスの抗腫瘍活性の向上

Enhancing Anti-Tumor Activity of Sorafenib Mesoporous Silica Nanomatrix in Metastatic Breast Tumor and Hepatocellular Carcinoma via the Co-Administration with Flufenamic Acid.
  • Zhuo-Yue Li
  • Yi-Fan Yin
  • Yang Guo
  • Hui Li
  • Mei-Qi Xu
  • Man Liu
  • Jing-Ru Wang
  • Zhen-Han Feng
  • Xiao-Chuan Duan
  • Shuang Zhang
  • Shuai-Qiang Zhang
  • Guang-Xue Wang
  • Ai Liao
  • Shu-Min Wang
  • Xuan Zhang
  • Int J Nanomedicine.2020;15:1809-1821. 240436. doi: 10.2147/IJN.S240436.Epub 2020-03-16.

転移性去勢抵抗性前立腺がんの男性におけるダサチニブまたはスニチニブの追加に無作為に割り付けたアビラテロンの第 2 相試験

A Phase 2 Trial of Abiraterone Followed by Randomization to Addition of Dasatinib or Sunitinib in Men With Metastatic Castration-Resistant Prostate Cancer.
  • Nicholas Spetsieris
  • Myrto Boukovala
  • Justin A Weldon
  • Alexandros Tsikkinis
  • Anh Hoang
  • Ana Aparicio
  • Shi-Ming Tu
  • John C Araujo
  • Amado J Zurita
  • Paul G Corn
  • Lance Pagliaro
  • Jeri Kim
  • Jennifer Wang
  • Sumit K Subudhi
  • Nizar M Tannir
  • Christopher J Logothetis
  • Patricia Troncoso
  • Xuemei Wang
  • Sijin Wen
  • Eleni Efstathiou
  • Clin Genitourin Cancer.2020 May;S1558-7673(20)30121-X. doi: 10.1016/j.clgc.2020.05.013.Epub 2020-05-30.

複雑な先天性心疾患を持つ患者の再発熱と脳膿瘍の原因としての心内膜炎。症例報告と文献レビュー

Endocarditis as the Cause of Recurrent Fever and Brain Abscess in a Patient with Complex Congenital Heart Disease: A Case Report and Literature Review.
  • Ioannis A Ziogas
  • Alexandros P Evangeliou
  • Olga Tsachouridou
  • Alexandra Arvanitaki
  • Afroditi Tsona
  • Vassilios Kamperidis
  • Marianthi Papagianni
  • Theofilos Panagiotidis
  • Ilias A Tourtounis
  • George Giannakoulas
  • Symeon Metallidis
  • Case Rep Infect Dis.2020;2020:7894574. doi: 10.1155/2020/7894574.Epub 2020-06-24.

アフラトキシン生合成経路のDおよびR遺伝子の発現をダウンレギュレーションすることによる根とアフィニン・スピラントールの抗真菌・抗アフラトキシン活性

Antifungal and anti-aflatoxigenic activity of roots and affinin/spilanthol against by downregulating the expression of D and R genes of the aflatoxins biosynthetic pathway.
  • Génesis V Buitimea-Cantúa
  • Nydia E Buitimea-Cantúa
  • María Del Refugio Rocha-Pizaña
  • Ema Carina Rosas-Burgos
  • Alejandro Hernández-Morales
  • Jorge Molina-Torres
  • J Environ Sci Health B.2020;55(3):210-219. doi: 10.1080/03601234.2019.1681818.Epub 2019-10-25.

心原性ショックにおける経カテーテル大動脈弁留置術（TAVI）：TAVIショックレジストリの結果

Transcatheter aortic valve implantation (TAVI) in cardiogenic shock: TAVI-shock registry results.
  • Chiara Fraccaro
  • Rui Campante Teles
  • Didier Tchétché
  • Francesco Saia
  • Francesco Bedogni
  • Matteo Montorfano
  • Claudia Fiorina
  • Francesco Meucci
  • Mauro De Benedictis
  • Ornella Leonzi
  • Marco Barbierato
  • Nicolas Dumonteil
  • Miroslava Stolcova
  • Diego Maffeo
  • Miriam Compagnone
  • João Brito
  • Alaide Chieffo
  • Giuseppe Tarantini
  • Catheter Cardiovasc Interv.2020 Jul;doi: 10.1002/ccd.29112.Epub 2020-07-06.

nulligravid女性におけるレボノルゲストレル52mg子宮内システム挿入時の激痛の予測因子

Predictors of severe pain during insertion of the levonorgestrel 52 mg intrauterine system among nulligravid women.
  • Letícia Sanchez Ferreira
  • Mariane Nunes de Nadai
  • Omero B Poli-Neto
  • Silvio A Franceschini
  • Cássia Rt Juliato
  • Ilza Maria U Monteiro
  • Luis Bahamondes
  • Carolina Sales Vieira
  • Contraception.2020 Jul;S0010-7824(20)30190-6. doi: 10.1016/j.contraception.2020.07.004.Epub 2020-07-14.

COVID-19肺炎重症患者におけるIL-2/IL-2Rの阻害は、JAK1-STAT5を介してCD8 T細胞とリンパ球の減少をもたらす

The inhibition of IL-2/IL-2R gives rise to CD8 T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia.
  • Hongbo Shi
  • Wenjing Wang
  • Jiming Yin
  • Yabo Ouyang
  • Lijun Pang
  • Yingmei Feng
  • Luxin Qiao
  • Xianghua Guo
  • Honglin Shi
  • Ronghua Jin
  • Dexi Chen
  • Cell Death Dis.2020 06;11(6):429. 10.1038/s41419-020-2636-4. doi: 10.1038/s41419-020-2636-4.Epub 2020-06-08.

層流は、長いノンコーディングRNA MALAT1の発現を維持することを介して血管内皮タイトジャンクションとバリア機能を保護する

Laminar Flow Protects Vascular Endothelial Tight Junctions and Barrier Function via Maintaining the Expression of Long Non-coding RNA MALAT1.
  • Fangfang Yang
  • Yunpeng Zhang
  • Juanjuan Zhu
  • Jin Wang
  • Zhitong Jiang
  • Chuanrong Zhao
  • Qianru Yang
  • Yu Huang
  • Weijuan Yao
  • Wei Pang
  • Lili Han
  • Jing Zhou
  • Front Bioeng Biotechnol.2020;8:647. doi: 10.3389/fbioe.2020.00647.Epub 2020-06-25.

ミトコンドリアヒスチジルtRNA合成酵素の過剰発現は、難聴に関連したtRNA変異に起因するミトコンドリア機能障害を回復させる

Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNA mutation.
  • Shasha Gong
  • Xiaoqiong Wang
  • Feilong Meng
  • Limei Cui
  • Qiuzi Yi
  • Qiong Zhao
  • Xiaohui Cang
  • Zhiyi Cai
  • Jun Qin Mo
  • Yong Liang
  • Min-Xin Guan
  • J. Biol. Chem..2020 Jan;295(4):940-954. RA119.010998. doi: 10.1074/jbc.RA119.010998.Epub 2019-12-09.

南洋の対照的な4つの地域におけるウイルスの豊富さと群集構成の評価

Assessing Viral Abundance and Community Composition in Four Contrasting Regions of the Southern Ocean.
  • Ana Sotomayor-Garcia
  • Maria Montserrat Sala
  • Isabel Ferrera
  • Marta Estrada
  • Evaristo Vázquez-Domínguez
  • Mikhail Emelianov
  • Pau Cortés
  • Cèlia Marrasé
  • Eva Ortega-Retuerta
  • Sdena Nunes
  • Yaiza M Castillo
  • Maria Serrano Cuerva
  • Marta Sebastián
  • Manuel Dall'Osto
  • Rafel Simó
  • Dolors Vaqué
  • Life (Basel).2020 Jul;10(7). E107. doi: 10.3390/life10070107.Epub 2020-07-05.

β遮断薬は、ニューロンにおける空間的に制限されたβARシグナル伝達を標的とすることで、L型Caチャネルの活性を増強する

β-blockers augment L-type Ca channel activity by targeting spatially restricted βAR signaling in neurons.
  • Ao Shen
  • Dana Chen
  • Manpreet Kaur
  • Peter Bartels
  • Bing Xu
  • Qian Shi
  • Joseph M Martinez
  • Kwun-Nok Mimi Man
  • Madeline Nieves-Cintron
  • Johannes W Hell
  • Manuel F Navedo
  • Xi-Yong Yu
  • Yang K Xiang
  • Elife.2019 10;8. e49464. doi: 10.7554/eLife.49464.Epub 2019-10-14.

妊娠誘発性高血圧はヒト臍帯静脈平滑筋におけるK1.3カリウムチャネルの発現と機能を低下させる

Pregnancy-induced hypertension decreases K1.3 potassium channel expression and function in human umbilical vein smooth muscle.
  • Vladimir Djokic
  • Svetlana Jankovic
  • Milica Labudovic-Borovic
  • Jelena Rakocevic
  • Jelena Stanisic
  • Jovana Rajkovic
  • Radmila Novakovic
  • Milan Kostic
  • Milos Djuric
  • Milos Gostimirovic
  • Ljiljana Gojkovic-Bukarica
  • Eur. J. Pharmacol..2020 Jun;882:173281. S0014-2999(20)30373-3. doi: 10.1016/j.ejphar.2020.173281.Epub 2020-06-17.

炎症性IFIT3は、膵臓癌におけるVDAC2の翻訳後修飾を調節することにより、化学療法抵抗性をもたらす

Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer.
  • Zhefang Wang
  • Jie Qin
  • Jiangang Zhao
  • Jiahui Li
  • Dai Li
  • Marie Popp
  • Felix Popp
  • Hakan Alakus
  • Bo Kong
  • Qiongzhu Dong
  • Peter J Nelson
  • Yue Zhao
  • Christiane J Bruns
  • Theranostics.2020;10(16):7178-7192. thnov10p7178. doi: 10.7150/thno.43093.Epub 2020-06-01.

生理的薬物動態モデルと薬物-標的滞留時間モデルの統合によるヒトにおけるトピロキソスタットの薬物動態と薬力学の予測

Prediction of the pharmacokinetics and pharmacodynamics of topiroxostat in humans by integrating the physiologically based pharmacokinetic model with the drug-target residence time model.
  • Zhiqiang Luo
  • Guohua Yu
  • Xing Han
  • Tingting Yang
  • Yanhua Ji
  • Huating Huang
  • Guopeng Wang
  • Yang Liu
  • Wenyan Sun
  • Biomed. Pharmacother..2020 Jan;121:109660. S0753-3322(19)35282-5. doi: 10.1016/j.biopha.2019.109660.Epub 2019-11-14.

心筋梗塞後の長期的な服薬アドヒアランスと心血管イベントの減少を支援する介入（ISLAND）：実用的無作為化比較試験

Interventions supporting long term adherence and decreasing cardiovascular events after myocardial infarction (ISLAND): pragmatic randomised controlled trial.
  • Noah M Ivers
  • Jon-David Schwalm
  • Zachary Bouck
  • Tara McCready
  • Monica Taljaard
  • Sherry L Grace
  • Jennifer Cunningham
  • Beth Bosiak
  • Justin Presseau
  • Holly O Witteman
  • Neville Suskin
  • Harindra C Wijeysundera
  • Clare Atzema
  • R Sacha Bhatia
  • Madhu Natarajan
  • Jeremy M Grimshaw
  • BMJ.2020 06;369:m1731. doi: 10.1136/bmj.m1731.Epub 2020-06-10.

大導電性カリウムチャネルの開通により、トリプルネガティブ乳がんの細胞死が選択的に誘導された

Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer.
  • Gina Sizemore
  • Sarah McLaughlin
  • Mackenzie Newman
  • Kathleen Brundage
  • Amanda Ammer
  • Karen Martin
  • Elena Pugacheva
  • James Coad
  • Malcolm D Mattes
  • Han-Gang Yu
  • BMC Cancer.2020 Jun;20(1):595. 10.1186/s12885-020-07071-1. doi: 10.1186/s12885-020-07071-1.Epub 2020-06-26.