胸水を伴う中耳炎の小児における肥大したアデノイドにおける血清インスリン様成長因子-1(IGF-1)およびグレリンのアデノイド摘出術の影響について

The effects of adenoidectomy of serum insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children with otitis media with effusion.

• Beata Żelazowska-Rutkowska
• Klaudia Jacewicz
• Edwina Kasprzycka
• Bożena Skotnicka
• Bogdan Cylwik

抄録

<b>目的:</b>本研究の目的は、胸水を伴う中耳炎の有無にかかわらず、アデノイド摘出術前後の肥大したアデノイドにおけるインスリン様成長因子-1 (IGF-1) とグレリンの血清レベルを評価することであった。<br><b>材料と方法：<br><b>血清中のIGF-1とグレリンの濃度を特異的酵素結合免疫測定法（ELISA）で測定しました。本研究は胸水を伴う中耳炎の小児20名を対象に実施した。<br><b>結果：<br><b>胸水を伴う中耳炎やアデノサイド切除前のアデノサイドが肥大した子供のIGF-1の平均値は、健康な子供に比べて有意に低かった。IGF-1の血清値はアデノイド摘出術後に高値を示した。<br><b>結論：</b>今回の結果から、アデノイドが肥大した子供や胸水を伴う中耳炎の子供のアデノイド切除術は、GH-IGF-1軸の効果により、手術前と比較して血清中のIGF-1レベルを有意に上昇させ、子供の成長に寄与する可能性が示唆されました。

&lt;b&gt;Aim:&lt;/b&gt; The aim of the current study was to assess the serum levels of insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children suffering with or without otitis media with effusion before and after adenoidectomy. &lt;br&gt;&lt;b&gt;Material and methods:&lt;/b&gt; Serum IGF-1 and ghrelin concentrations were measured with specific enzyme-linked immunoassay (ELISA) methods. The study was carried out in 20 children with otitis media with effusion. The reference group comprised 24 children with hypertrophied adenoid, while control group included 19 children. &lt;br&gt;&lt;b&gt;Results:&lt;/b&gt; This mean values of IGF-1 in children with otitis media with effusion and children with hypertrophied adenoid before adenoidectomy were significantly lower than those found in healthy children. Serum levels of IGF-1 were higher after adenoidectomy. There was a significant difference of serum ghrelin levels between both examined groups and the control group. &lt;br&gt;&lt;b&gt;Conclusion:&lt;/b&gt; Our results suggest that adenoidectomy in children with hypertrophied adenoids and in children with otitis media with effusion significantly increases the level of IGF-1 in serum compared to before surgery through the effect of the GH-IGF-1 axis, which could contribute to children's growth.