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日本語AIでPubMedを検索

歯科医師情報サイトTOP / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
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2020年07月 みんなが読んでいる論文

モノアシルグリセロールリパーゼの阻害は、オスマウスの条件付き場所選好試験におけるニコチン報酬を減少させる

Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice.
  • Pretal P Muldoon
  • Lois S Akinola
  • Joel E Schlosburg
  • Aron H Lichtman
  • Laura J Sim-Selley
  • Anu Mahadevan
  • Benjamin F Cravatt
  • M Imad Damaj
  • Neuropharmacology.2020 May;176:108170. S0028-3908(20)30238-0. doi: 10.1016/j.neuropharm.2020.108170.Epub 2020-05-30.

びまん性悪性腹膜中皮腫におけるKi67パーセンテージ、WT-1発現、およびp16/CDKN2A欠失の予後評価。単施設コホート研究

Prognostic Value of Ki67 Percentage, WT-1 Expression and p16/CDKN2A Deletion in Diffuse Malignant Peritoneal Mesothelioma: A Single-Centre Cohort Study.
  • Federica Pezzuto
  • Gabriella Serio
  • Francesco Fortarezza
  • Anna Scattone
  • Concetta Caporusso
  • Alessandra Punzi
  • Domenica Cavone
  • Antonio Pennella
  • Andrea Marzullo
  • Luigi Vimercati
  • Diagnostics (Basel).2020 Jun;10(6). E386. doi: 10.3390/diagnostics10060386.Epub 2020-06-09.

銃器がカートリッジケースに残した刻印の比較と解釈 - 尤度比に基づく手法の実用化に向けて

Comparison and interpretation of impressed marks left by a firearm on cartridge cases - Towards an operational implementation of a likelihood ratio based technique.
  • Fabiano Riva
  • Erwin J A T Mattijssen
  • Rob Hermsen
  • Pascal Pieper
  • W Kerkhoff
  • Christophe Champod
  • Forensic Sci. Int..2020 Aug;313:110363. S0379-0738(20)30225-5. doi: 10.1016/j.forsciint.2020.110363.Epub 2020-06-10.

FcγRII（CD32）はNOD SCIDマウスにおける抗体クリアランスを調節し、抗体を介した腫瘍細胞削除の障害をもたらすことを明らかにした

FcγRII (CD32) modulates antibody clearance in NOD SCID mice leading to impaired antibody-mediated tumor cell deletion.
  • Robert J Oldham
  • C Ian Mockridge
  • Sonya James
  • Patrick J Duriez
  • H T Claude Chan
  • Kerry L Cox
  • Vicentiu A Pitic
  • Martin J Glennie
  • Mark S Cragg
  • J Immunother Cancer.2020 Jun;8(1). e000619. doi: 10.1136/jitc-2020-000619.

BAG-1 mRNAの5'UTRに位置するG-quadruplexは、グローバルな二次構造維持を介して、キャップ依存性およびキャップ非依存性の翻訳に影響を与える

G-quadruplex located in the 5'UTR of the BAG-1 mRNA affects both its cap-dependent and cap-independent translation through global secondary structure maintenance.
  • Rachel Jodoin
  • Julie C Carrier
  • Nathalie Rivard
  • Martin Bisaillon
  • Jean-Pierre Perreault
  • Nucleic Acids Res..2019 11;47(19):10247-10266. 5559686. doi: 10.1093/nar/gkz777.

ミュンヘン比較試験。経カテーテル式メロディ弁と外科的肺バイオプロステーシスのプロスペクティブな長期成績と最大12年間の追跡調査

Munich Comparative Study: Prospective Long-Term Outcome of the Transcatheter Melody Valve Versus Surgical Pulmonary Bioprosthesis With Up to 12 Years of Follow-Up.
  • Stanimir Georgiev
  • Peter Ewert
  • Andreas Eicken
  • Alfred Hager
  • Jürgen Hörer
  • Julie Cleuziou
  • Christian Meierhofer
  • Daniel Tanase
  • Circ Cardiovasc Interv.2020 Jul;13(7):e008963. doi: 10.1161/CIRCINTERVENTIONS.119.008963.

癌を持つ小児および青年の心理的ウェルビーイングに対処するためのImmersive Virtual Reality Interventionの実現可能性、受容性、および臨床的実施

Feasibility, Acceptability, and Clinical Implementation of an Immersive Virtual Reality Intervention to Address Psychological Well-Being in Children and Adolescents With Cancer.
  • Michelle Tennant
  • Jane McGillivray
  • George J Youssef
  • Maria C McCarthy
  • Tara-Jane Clark
  • J Pediatr Oncol Nurs.2020 Jul/Aug;37(4):265-277. doi: 10.1177/1043454220917859.

2型糖尿病および既往の心血管疾患患者における低密度リポ蛋白コレステロール治療と転帰。TECOSからの洞察

Low-density lipoprotein cholesterol treatment and outcomes in patients with type 2 diabetes and established cardiovascular disease: Insights from TECOS.
  • Gaetano M De Ferrari
  • Susanna R Stevens
  • Giuseppe Ambrosio
  • Sergio Leonardi
  • Paul W Armstrong
  • Jennifer B Green
  • Malgorzata Wamil
  • Rury R Holman
  • Eric D Peterson
  • Am. Heart J..2020 02;220:82-88. S0002-8703(19)30306-0. doi: 10.1016/j.ahj.2019.11.005.Epub 2019-11-13.

肺炎を引き起こす加齢と治療関連の低ガンマグロブリン血症。混沌としたCOVID-19パンデミックにおける見落とされた治療可能なエンティティ

Aging and Therapy-Related Hypogammaglobulinemia causing Pneumonia: An Overlooked Curable Entity in the Chaotic COVID-19 Pandemic.
  • Syed Ziauddin Ahmed Zaidi
  • Fatima Zia Zaidi
  • Nawal AlShehry
  • Abdul Rehman Zia Zaidi
  • Saleha Zia Zaidi
  • Syed Maaz Abdullah
  • J. Med. Virol..2020 Jul;doi: 10.1002/jmv.26318.Epub 2020-07-18.

穏やかな熱と植物精油成分を組み合わせて、バッファー中およびココナッツ水中で大腸菌の耐性変異体を不活化する

Combination of mild heat and plant essential oil constituents to inactivate resistant variants of Escherichia coli in buffer and in coconut water.
  • Elisa Gayán
  • Elise Geens
  • Daniel Berdejo
  • Diego García-Gonzalo
  • Rafael Pagán
  • Abram Aertsen
  • Chris W Michiels
  • Food Microbiol..2020 May;87:103388. S0740-0020(19)30998-0. doi: 10.1016/j.fm.2019.103388.Epub 2019-11-26.

臨床中等度・重症感染症における病原体診断におけるメタゲノム次世代シークエンシングの適用に関する専門家のコンセンサス（初版）

[Expert consensus for the application of metagenomic next generation sequencing in the pathogen diagnosis in clinical moderate and severe infections (first edition)].
  • Consensus Group Of Experts On Application Of Metagenomic Next Generation Sequencing In The Pathogen Diagnosis In Clinical Moderate And Severe Infections
  • Professional Committee Of Sepsis And Shock Chinese Research Hospital Association
  • Professional Committee Of Microbial Toxins Chinese Society For Microbiology
  • Professional Committee Of Critical Care Medicine Shenzhen Medical Association
  • Zhonghua Wei Zhong Bing Ji Jiu Yi Xue.2020 05;32(5):531-536. doi: 10.3760/cma.j.cn121430-20200228-00095.

高齢者の身体能力と生活の質。多動性オクトジェニアンにおける薬物相互作用の可能性とこれらの間に関連性はあるか

Physical Performance and Quality of Life in Older Adults: Is There Any Association between Them and Potential Drug Interactions in Polymedicated Octogenarians.
  • Zoraida Verde
  • Laura García de Diego
  • Luis M Chicharro
  • Fernando Bandrés
  • Verónica Velasco
  • Teresa Mingo
  • Ana Fernández-Araque
  • Int J Environ Res Public Health.2019 10;16(21). E4190. doi: 10.3390/ijerph16214190.Epub 2019-10-29.

免疫細胞を標的とした治療法の効果は、実験的な糖尿病ラットにおける神経細胞の酸化ストレスおよび炎症の抑制に起因すると考えられる

Effects of immune cell-targeted treatments result from the suppression of neuronal oxidative stress and inflammation in experimental diabetic rats.
  • Tufan Mert
  • Emel Sahin
  • Selma Yaman
  • Mehmet Sahin
  • Naunyn Schmiedebergs Arch. Pharmacol..2020 Jul;393(7):1293-1302. 10.1007/s00210-020-01871-9. doi: 10.1007/s00210-020-01871-9.Epub 2020-05-02.

川崎病における冠動脈病変予測のための構造方程式モデルとニューラルネットワーク解析：単施設レトロスペクティブ研究

Structure equation model and neural network analyses to predict coronary artery lesions in Kawasaki disease: a single-centre retrospective study.
  • Junji Azuma
  • Takehisa Yamamoto
  • Motoaki Nitta
  • Yasuhiro Hasegawa
  • Eri Kijima
  • Tsunesuke Shimotsuji
  • Yoshimi Mizoguchi
  • Sci Rep.2020 Jul;10(1):11868. 10.1038/s41598-020-68657-0. doi: 10.1038/s41598-020-68657-0.Epub 2020-07-17.

キク科アルテミシアの空中部分から抗真菌作用を有する8つの既知化合物と一緒に新規な不定形モノテルペンアセテートを合成した

A new irregular monoterpene acetate along with eight known compounds with antifungal potential from the aerial parts of Artemisia incisa Pamp (Asteraceae).
  • Mamoon Ur Rashid
  • Muhammad Alamzeb
  • Saqib Ali
  • Zafar Ali Shah
  • Ishrat Naz
  • Ashfaq Ahmad Khan
  • Dima Semaan
  • Mohammad Rafiullah Khan
  • Nat. Prod. Res..2017 Feb;31(4):428-435. doi: 10.1080/14786419.2016.1185718.Epub 2016-05-17.

冠動脈アクセスと経皮的冠動脈インターベンション バルーン拡張可能な大動脈弁を用いた経カテーテル大動脈弁留置術後3年まで

Coronary Access and Percutaneous Coronary Intervention Up to 3 Years After Transcatheter Aortic Valve Implantation With a Balloon-Expandable Valve.
  • Giuseppe Tarantini
  • Luca Nai Fovino
  • Pascal Le Prince
  • Olivier Darremont
  • Marina Urena
  • Antonio L Bartorelli
  • Flavien Vincent
  • Tomas Hovorka
  • Yasmina Alcalá Navarro
  • Nicolas Dumonteil
  • Patrick Ohlmann
  • Olaf Wendler
  • Circ Cardiovasc Interv.2020 Jul;13(7):e008972. doi: 10.1161/CIRCINTERVENTIONS.120.008972.Epub 2020-06-25.

原発性抗悪性腫瘍治療中の肺がん患者における栄養不良に対するマルチモーダル介入の実行可能性

Feasibility of a multimodal intervention on malnutrition in patients with lung cancer during primary anti-neoplastic treatment.
  • Randi Tobberup
  • Andreas Carus
  • Henrik H Rasmussen
  • Ursula G Falkmer
  • Martin G Jorgensen
  • Erik B Schmidt
  • Nikolaj A Jensen
  • Esben B Mark
  • Agnieszka M Delekta
  • Christian S Antoniussen
  • Martin Bøgsted
  • Mette Holst
  • Clin Nutr.2020 Jun;S0261-5614(20)30287-9. doi: 10.1016/j.clnu.2020.05.050.Epub 2020-06-09.

トランスクリプトームと代謝物解析の結果、キビタキビの干ばつ耐性は、PEG ストレス下での発芽過程においてフェニルプロパノイド関連経路と有意に相関していることが明らかになった

Transcriptome and metabolite analysis reveal the drought tolerance of foxtail millet significantly correlated with phenylpropanoids-related pathways during germination process under PEG stress.
  • Aili Yu
  • Jinfeng Zhao
  • Zhenhua Wang
  • Kai Cheng
  • Peng Zhang
  • Gang Tian
  • Xin Liu
  • Erhu Guo
  • Yanwei Du
  • Yuwen Wang
  • BMC Plant Biol..2020 Jun;20(1):274. 10.1186/s12870-020-02483-4. doi: 10.1186/s12870-020-02483-4.Epub 2020-06-15.

エプレレノンによる急性防御反応の調節は、ウイルス性心筋炎における心疾患の進行を防ぐ

Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis.
  • Carsten Tschöpe
  • Sophie Van Linthout
  • Sebastian Jäger
  • Robert Arndt
  • Tobias Trippel
  • Irene Müller
  • Ahmed Elsanhoury
  • Susanne Rutschow
  • Stefan D Anker
  • Heinz-Peter Schultheiss
  • Matthias Pauschinger
  • Frank Spillmann
  • Kathleen Pappritz
  • ESC Heart Fail.2020 Jul;doi: 10.1002/ehf2.12887.Epub 2020-07-14.

スタチン治療中の2型糖尿病患者におけるアナグリプチンとシタグリプチンの脂質代謝の違い：REASON試験の二次解析

Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial.
  • Atsuko Chihara
  • Atsushi Tanaka
  • Takeshi Morimoto
  • Mio Sakuma
  • Michio Shimabukuro
  • Takashi Nomiyama
  • Osamu Arasaki
  • Shinichiro Ueda
  • Koichi Node
  • Cardiovasc Diabetol.2019 11;18(1):158. 10.1186/s12933-019-0965-3. doi: 10.1186/s12933-019-0965-3.Epub 2019-11-16.

脱灰した単一インプラント部位のガイド付き骨再生のために新規コラーゲン膜を使用した多施設無作為化比較試験。補綴物の引渡し時と1年後の経過観察時のアウトカム

A multicenter randomized controlled trial using a novel collagen membrane for guided bone regeneration at dehisced single implant sites: Outcome at prosthetic delivery and at 1-year follow-up.
  • Istvan A Urban
  • Bastian Wessing
  • Nuria Alández
  • Silvio Meloni
  • Oscar González-Martin
  • Giovanni Polizzi
  • Igancio Sanz-Sanchez
  • Eduardo Montero
  • Werner Zechner
  • Clin Oral Implants Res.2019 Jun;30(6):487-497. doi: 10.1111/clr.13426.Epub 2019-05-14.

インド亜大陸ではフレームシフト変異体(c.409dupG)が先天性のサジロ芽球性貧血の原因となっていることが明らかになった

Novel frameshift variant (c.409dupG) in is a common cause of congenital sideroblastic anaemia in the Indian subcontinent.
  • Niveditha Ravindra
  • Rekha Athiyarath
  • Eswari S
  • Sumithra S
  • Uday Kulkarni
  • Fouzia N A
  • Anu Korula
  • Ramachandran V Shaji
  • Biju George
  • Eunice Sindhuvi Edison
  • J. Clin. Pathol..2020 Jun;jclinpath-2020-206647. doi: 10.1136/jclinpath-2020-206647.Epub 2020-06-30.

ソフォスブビルは、アカゲザルにおけるジカウイルスの垂直伝播とそれに伴う先天性症候群に対する保護効果を示す

Sofosbuvir shows a protective effect against vertical transmission of Zika virus and the associated congenital syndrome in rhesus monkeys.
  • Noemi R Gardinali
  • Renato S Marchevsky
  • Jaqueline M Oliveira
  • Marcelo Pelajo-Machado
  • Tatiana Kugelmeier
  • Marcio P Castro
  • Aline C A Silva
  • Douglas P Pinto
  • Lais B Fonseca
  • Leandro S Vilhena
  • Heliana M Pereira
  • Sheila M B Lima
  • Emily H Miranda
  • Gisela F Trindade
  • José H R Linhares
  • Stephanie A Silva
  • Juliana Gil Melgaco
  • Ada M B Alves
  • Julio Moran
  • Maria C C Silva
  • Rômulo J Soares-Bezerra
  • Andreza Soriano
  • Gentil A Bentes
  • Fernanda de Oliveira Bottino
  • Sarah Beatriz Salvador Castro Faria
  • Rafael F Nudelman
  • Claudia A A Lopes
  • Javier A S Perea
  • Klena Sarges
  • Márcia C R Andrade
  • Márcia C V A Motta
  • Marcos S Freire
  • Thiago M L Souza
  • Jonas Schmidt-Chanasit
  • Marcelo A Pinto
  • Antiviral Res..2020 Jul;:104859. S0166-3542(20)30273-4. doi: 10.1016/j.antiviral.2020.104859.Epub 2020-07-07.

抗菌フィルム含浸による留置型尿道カテーテルにおけるProteus mirabilisのコロニー化と群集運動性の減衰。インビトロでの研究

Attenuation of Proteus mirabilis colonization and swarming motility on indwelling urinary catheter by antibiofilm impregnation: An in vitro study.
  • Ravindran Durgadevi
  • Ramaiah Kaleeshwari
  • Thirukannamangai Krishnan Swetha
  • Rajaiah Alexpandi
  • Shunmugaiah Karutha Pandian
  • Arumugam Veera Ravi
  • Colloids Surf B Biointerfaces.2020 Jun;194:111207. S0927-7765(20)30563-4. doi: 10.1016/j.colsurfb.2020.111207.Epub 2020-06-18.

アドレナリンの精製を記した4つの文献を比較し、上中敬三、永井長吉、高峰譲吉の3人の重要な研究者の仕事を紹介しています

Comparison of four documents describing adrenaline purification, and the work of three important scientists, Keizo Uenaka, Nagai Nagayoshi and Jokichi Takamine.
  • Rie Mieda
  • Chizu Aso
  • Tadanao Hiroki
  • Masafumi Kanamoto
  • Takashi Suto
  • Masaru Tobe
  • Shigeru Saito
  • J Anesth Hist.2020 Jun;6(2):42-48. S2352-4529(20)30008-6. doi: 10.1016/j.janh.2020.04.001.Epub 2020-04-28.

STOVES試験におけるクッキングストーブ大気汚染への制御された暴露に続く血中脂質および炎症性バイオマーカーの急性差

Acute differences in blood lipids and inflammatory biomarkers following controlled exposures to cookstove air pollution in the STOVES study.
  • Ethan S Walker
  • Kristen M Fedak
  • Nicholas Good
  • John Balmes
  • Robert D Brook
  • Maggie L Clark
  • Tom Cole-Hunter
  • Robert B Devlin
  • Christian L'Orange
  • Gary Luckasen
  • John Mehaffy
  • Rhiannon Shelton
  • Ander Wilson
  • John Volckens
  • Jennifer L Peel
  • Int J Environ Health Res.2020 Jul;:1-14. doi: 10.1080/09603123.2020.1785402.Epub 2020-07-02.

サウジアラビア産Gerbillus nanusのBartonellaの分子解析により、高いレベルの有病率、多様性、および共感染が明らかになった

Molecular assessment of Bartonella in Gerbillus nanus from Saudi Arabia reveals high levels of prevalence, diversity and co-infection.
  • Dewald J Kleynhans
  • Joshua Sarli
  • Luiza M Hatyoka
  • Abdulaziz N Alagaili
  • Nigel C Bennett
  • Osama B Mohammed
  • Armanda D S Bastos
  • Infect. Genet. Evol..2018 11;65:244-250. S1567-1348(18)30555-0. doi: 10.1016/j.meegid.2018.07.036.Epub 2018-07-30.

常染色体優性アルツハイマー病変種におけるアミロイド、タウ、アストロサイトの病理。AβPParcとPSEN1DE9

Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer's disease variants: AβPParc and PSEN1DE9.
  • Laetitia Lemoine
  • Per-Göran Gillberg
  • Nenad Bogdanovic
  • Inger Nennesmo
  • Laure Saint-Aubert
  • Matti Viitanen
  • Caroline Graff
  • Martin Ingelsson
  • Agneta Nordberg
  • Mol. Psychiatry.2020 Jun;10.1038/s41380-020-0817-2. doi: 10.1038/s41380-020-0817-2.Epub 2020-06-25.

重度のてんかんと歯肉過形成を合併した少年における多発性先天性異常-ハイポトニア-痙攣症候群2（MCAHS2）の新規変異

A Novel Mutation in Associated with Multiple Congenital Anomalies-Hypotonia-Seizure Syndrome 2 (MCAHS2) in a Boy with a Combination of Severe Epilepsy and Gingival Hyperplasia.
  • Christiane M Neuhofer
  • Rudolf Funke
  • Bernd Wilken
  • Alexej Knaus
  • Janine Altmüller
  • Peter Nürnberg
  • Yun Li
  • Bernd Wollnik
  • Peter Burfeind
  • Silke Pauli
  • Mol Syndromol.2020 Feb;11(1):30-37. msy-0011-0030. doi: 10.1159/000505797.Epub 2020-02-05.

マクロピノサイトーシスとクラスリン依存性エンドサイトーシスがプーマラウイルスの感染経路に重要な役割を果たしている

Macropinocytosis and Clathrin-Dependent Endocytosis Play Pivotal Roles for the Infectious Entry of Puumala Virus.
  • Sandy Bauherr
  • Filip Larsberg
  • Annett Petrich
  • Hannah Sabeth Sperber
  • Victoria Klose-Grzelka
  • Madlen Luckner
  • Walid Azab
  • Matthias Schade
  • Chris Tina Höfer
  • Maik Joerg Lehmann
  • Peter T Witkowski
  • Detlev H Krüger
  • Andreas Herrmann
  • Roland Schwarzer
  • J. Virol..2020 Jul;94(14). e00184-20. doi: 10.1128/JVI.00184-20.Epub 2020-07-01.

延長された炭鉱火災からの煙への暴露に続く苦痛と関連した要因

The factors associated with distress following exposure to smoke from an extended coal mine fire.
  • Jonathan C Broder
  • Caroline X Gao
  • Timothy C H Campbell
  • Emily Berger
  • Darryl Maybery
  • Alexander McFarlane
  • Jessica Tsoutsoulis
  • Jillian Ikin
  • Michael J Abramson
  • Malcolm R Sim
  • Judi Walker
  • Ashok Luhar
  • Matthew Carroll
  • Environ. Pollut..2020 Jul;266(Pt 2):115131. S0269-7491(19)37390-7. doi: 10.1016/j.envpol.2020.115131.Epub 2020-07-04.

慢性C型肝炎ウイルスジェノタイプ4感染症患者における耐性関連置換

Resistance-associated substitutions in patients with chronic hepatitis C virus genotype 4 infection.
  • Julia Dietz
  • Olga V Kalinina
  • Johannes Vermehren
  • Kai-Henrik Peiffer
  • Katrin Matschenz
  • Peter Buggisch
  • Claus Niederau
  • Jörn M Schattenberg
  • Beat Müllhaupt
  • Sabine Yerly
  • Marc Ringelhan
  • Roland M Schmid
  • Christoph Antoni
  • Tobias Müller
  • Julian Schulze Zur Wiesch
  • Felix Piecha
  • Darius Moradpour
  • Katja Deterding
  • Heiner Wedemeyer
  • Christophe Moreno
  • Thomas Berg
  • Christoph P Berg
  • Stefan Zeuzem
  • Christoph Welsch
  • Christoph Sarrazin
  • J. Viral Hepat..2020 May;doi: 10.1111/jvh.13322.Epub 2020-05-12.

GLAのc.610T > C変異を持つ女性患者の初の表現型の記述：ファブリー病の腎優位性の臨床症状

First phenotypic description of a female patient with c.610 T > C variant of GLA: a renal-predominant presentation of Fabry disease.
  • Sophie Greillier
  • Laurent Daniel
  • Catherine Caillaud
  • Bertrand Dussol
  • Guy Touchard
  • Jean-Michel Goujon
  • Noémie Jourde-Chiche
  • Mickaël Bobot
  • BMC Med. Genet..2020 Jun;21(1):137. 10.1186/s12881-020-01071-5. doi: 10.1186/s12881-020-01071-5.Epub 2020-06-26.

メキシコ産の血を吸うコウモリバエからのバルテロネラ菌の分子検出

Molecular Detection of Bartonella Species in Blood-Feeding Bat Flies from Mexico.
  • Alexandra E Moskaluk
  • Matthew J Stuckey
  • David A Jaffe
  • Rickie W Kasten
  • Alvaro Aguilar-Setién
  • José Ignacio Olave-Leyva
  • Guillermo Galvez-Romero
  • Cirani Obregón-Morales
  • Mónica Salas-Rojas
  • María Martha García-Flores
  • Nidia Aréchiga-Ceballos
  • Anahí García-Baltazar
  • Bruno B Chomel
  • Vector Borne Zoonotic Dis..2018 05;18(5):258-265. doi: 10.1089/vbz.2017.2213.Epub 2018-03-13.

精子鞭毛1は、腸管上皮細胞のアクチンと結合し、糸状体と薄板体の形成に関与していることを明らかにした

Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.
  • Rocio Tapia
  • Eloy A Perez-Yepez
  • Maximillian J Carlino
  • Umesh C Karandikar
  • Sarah E Kralicek
  • Mary K Estes
  • Gail A Hecht
  • Gastroenterology.2019 12;157(6):1544-1555.e3. S0016-5085(19)41256-0. doi: 10.1053/j.gastro.2019.08.031.Epub 2019-08-29.

進行性新生物を有する参加者の4分の1は、大腸がんスクリーニングのための2サンプルの糞便免疫化学的検査の結果が不一致である

A Quarter of Participants With Advanced Neoplasia Have Discordant Results From 2-Sample Fecal Immunochemical Tests for Colorectal Cancer Screening.
  • Els Wieten
  • Clasine M de Klerk
  • Iris Lansdorp-Vogelaar
  • Patrick M Bossuyt
  • Evelien Dekker
  • Manon C W Spaander
  • Clin. Gastroenterol. Hepatol..2020 Jul;18(8):1805-1811.e1. S1542-3565(19)31030-4. doi: 10.1016/j.cgh.2019.09.024.Epub 2019-09-26.

ヒト歯根膜幹細胞の細胞外小胞には、原始癌遺伝子に関連したマイクロRNAが含まれている。サイトカインシスにおける意味合い

Extracellular Vesicles of Human Periodontal Ligament Stem Cells Contain MicroRNAs Associated to Proto-Oncogenes: Implications in Cytokinesis.
  • Luigi Chiricosta
  • Serena Silvestro
  • Agnese Gugliandolo
  • Guya Diletta Marconi
  • Jacopo Pizzicannella
  • Placido Bramanti
  • Oriana Trubiani
  • Emanuela Mazzon
  • Front Genet.2020;11:582. doi: 10.3389/fgene.2020.00582.Epub 2020-06-04.

MYC-GCN2-eIF2α負のフィードバックループがタンパク質合成を制限し、大腸がんのMYC依存性アポトーシスを防ぐ

A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.
  • Stefanie Schmidt
  • David Gay
  • Friedrich Wilhelm Uthe
  • Sarah Denk
  • Madelon Paauwe
  • Niels Matthes
  • Markus Elmar Diefenbacher
  • Sheila Bryson
  • Fiona Clare Warrander
  • Florian Erhard
  • Carsten Patrick Ade
  • Apoorva Baluapuri
  • Susanne Walz
  • Rene Jackstadt
  • Catriona Ford
  • Georgios Vlachogiannis
  • Nicola Valeri
  • Christoph Otto
  • Christina Schülein-Völk
  • Katja Maurus
  • Werner Schmitz
  • John Raymond Philip Knight
  • Elmar Wolf
  • Douglas Strathdee
  • Almut Schulze
  • Christoph-Thomas Germer
  • Andreas Rosenwald
  • Owen James Sansom
  • Martin Eilers
  • Armin Wiegering
  • Nat. Cell Biol..2019 11;21(11):1413-1424. 10.1038/s41556-019-0408-0. doi: 10.1038/s41556-019-0408-0.Epub 2019-11-04.

シクロオキシゲナーゼ-2、15-リポキシゲナーゼ、腫瘍関連炭酸脱水酵素を同時に標的とした1,2,3-トリアゾールの抗がん剤としての可能性の拡大

Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.
  • Perihan A Elzahhar
  • Shrouk M Abd El Wahab
  • Mohamed Elagawany
  • Hoda Daabees
  • Ahmed S F Belal
  • Ahmed F El-Yazbi
  • Ali H Eid
  • Rana Alaaeddine
  • Rehab R Hegazy
  • Rasha M Allam
  • Maged W Helmy
  • Bahaa Elgendy
  • Andrea Angeli
  • Soad A El-Hawash
  • Claudiu T Supuran
  • Eur J Med Chem.2020 Aug;200:112439. S0223-5234(20)30410-4. doi: 10.1016/j.ejmech.2020.112439.Epub 2020-05-25.

大規模ホスホプロテオーム研究におけるトリプシンとリサルジナーゼのミラースペクトルの組み合わせによるホスホサイト局在の明確化

Unambiguous Phosphosite Localization through the Combination of Trypsin and LysargiNase Mirror Spectra in a Large-Scale Phosphoproteome Study.
  • Feng Xu
  • Li Yu
  • Xuehui Peng
  • Junling Zhang
  • Suzhen Li
  • Shu Liu
  • Yanan Yin
  • Zhiwu An
  • Fuqiang Wang
  • Yan Fu
  • Ping Xu
  • J. Proteome Res..2020 Jun;19(6):2185-2194. doi: 10.1021/acs.jproteome.9b00562.Epub 2020-05-26.

リガンドサイズと共役化学がユニバーサルキメラ抗原受容体T細胞の腫瘍殺傷能に与える影響

Impact of Ligand Size and Conjugation Chemistry on the Performance of Universal Chimeric Antigen Receptor T-Cells for Tumor Killing.
  • Christian Pellegrino
  • Nicholas Favalli
  • Michael Sandholzer
  • Laura Volta
  • Gabriele Bassi
  • Jacopo Millul
  • Samuele Cazzamalli
  • Mattia Matasci
  • Alessandra Villa
  • Renier Myburgh
  • Markus G Manz
  • Dario Neri
  • Bioconjug. Chem..2020 Jul;31(7):1775-1783. doi: 10.1021/acs.bioconjchem.0c00258.Epub 2020-06-23.

RP2のノックアウトはGRK1とロッドトランスデューシンのサブユニットを減少させ、ゼブラフィッシュの光受容体の変性を引き起こす

Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish.
  • Fei Liu
  • Jiaxiang Chen
  • Shanshan Yu
  • Rakesh Kotapati Raghupathy
  • Xiliang Liu
  • Yayun Qin
  • Chang Li
  • Mi Huang
  • Shengjie Liao
  • Jiuxiang Wang
  • Jian Zou
  • Xinhua Shu
  • Zhaohui Tang
  • Mugen Liu
  • Hum. Mol. Genet..2015 Aug;24(16):4648-59. ddv197. doi: 10.1093/hmg/ddv197.Epub 2015-06-01.

イランにおけるヒトT細胞リンパ刺激性ウイルス1型（HTLV-1）の系統学的・系統力学的研究

Phylogenetic and phylodynamic study of Human T-cell lymphotropic virus Type 1 (HTLV-1) in Iran.
  • Cobra Razavi Pashabayg
  • Navid Momenifar
  • Seyed Amir Malekpour
  • Mehdi Sadeghi
  • Abbas Rahimi Foroushani
  • Houshang Rafatpanah
  • Narges Valizadeh
  • Faezeh Sabet
  • Seyed Mohammad Jazayeri
  • Hossein Keyvani
  • Seyed Abdolrahim Rezaee
  • Mehdi Norouzi
  • Infect. Genet. Evol..2020 Jun;85:104426. S1567-1348(20)30257-4. doi: 10.1016/j.meegid.2020.104426.Epub 2020-06-16.

合成カンナビノイド使用障害患者におけるCOMT（rs4680）、CNR2（rs2501432）、CNR2（rs2229579）、UCP2（rs659366）、およびIL-17（rs763780）遺伝子変異の評価

Evaluation of COMT (rs4680), CNR2 (rs2501432), CNR2 (rs2229579), UCP2 (rs659366), and IL-17 (rs763780) gene variants in synthetic cannabinoid use disorder patients.
  • Sacide Pehlivan
  • Hasan Mervan Aytac
  • Selin Kurnaz
  • Mustafa Pehlivan
  • Pinar Cetinay Aydin
  • J Addict Dis.2020 Jul;:1-11. doi: 10.1080/10550887.2020.1787770.Epub 2020-07-14.

ランオフ路上衝突におけるドライバーの傷害重症度に影響を与える要因の時間的安定性。平均値に不均一性を持たせたランダムパラメータ順序付きプロビットモデルのアプローチ

The temporal stability of factors affecting driver injury severity in run-off-road crashes: A random parameters ordered probit model with heterogeneity in the means approach.
  • Miao Yu
  • Changjiang Zheng
  • Changxi Ma
  • Jinxing Shen
  • Accid Anal Prev.2020 Jul;144:105677. S0001-4575(20)30752-1. doi: 10.1016/j.aap.2020.105677.Epub 2020-07-15.

抗生物質が枯渇したマイクロバイオームが、マウスモデルにおいて、カンピロバクター・ジェジュニが介在する重度の1/17型大腸炎、2型自己免疫、神経学的後遺症を引き起こしている

An antibiotic depleted microbiome drives severe Campylobacter jejuni-mediated Type 1/17 colitis, Type 2 autoimmunity and neurologic sequelae in a mouse model.
  • Phillip T Brooks
  • Julia A Bell
  • Christopher E Bejcek
  • Ankit Malik
  • Linda S Mansfield
  • J. Neuroimmunol..2019 12;337:577048. S0165-5728(19)30214-0. doi: 10.1016/j.jneuroim.2019.577048.Epub 2019-09-04.

カテコラミン作動性多型心室頻拍変異に伴うペースメーカーの機能不全は、異なるメカニズムによって媒介されている。症例数が多いことから、その結果をもとにした研究が行われています

Distinct mechanisms mediate pacemaker dysfunction associated with catecholaminergic polymorphic ventricular tachycardia mutations: Insights from computational modeling.
  • Limor Arbel-Ganon
  • Joachim A Behar
  • Ana María Gómez
  • Yael Yaniv
  • J. Mol. Cell. Cardiol..2020 Jun;143:85-95. S0022-2828(20)30100-0. doi: 10.1016/j.yjmcc.2020.04.017.Epub 2020-04-25.

著者の訂正。ストロンチウムラネレートは、インビトロでは歯乳頭細胞のオドント/造骨分化/石灰化を促進し、インビボでは歯髄の石灰化組織形成を促進します

Author Correction: Strontium ranelate promotes odonto-/osteogenic differentiation/mineralization of dental papillae cells in vitro and mineralized tissue formation of the dental pulp in vivo.
  • Alamuddin Bakhit
  • Nobuyuki Kawashima
  • Kentaro Hashimoto
  • Sonoko Noda
  • Keisuke Nara
  • Masashi Kuramoto
  • Kento Tazawa
  • Takashi Okiji
  • Sci Rep.2020 May;10(1):8375. 10.1038/s41598-020-65509-9. doi: 10.1038/s41598-020-65509-9.Epub 2020-05-15.

ヒト骨格筋の毛細血管、3種類の筋線維、基底ラミナを同時に同定するための2つの新しい信頼性の高い免疫組織化学的手法を開発した

Two new reliable immunohistochemical methods for simultaneous identification of capillaries, the three types of fibers and basal lamina in human skeletal muscle.
  • Mélina Bailly
  • Léonard Féasson
  • Bruno Pereira
  • Amandine Boileau
  • Christophe Hourdé
  • Natacha Germain
  • Bogdan Galusca
  • Daniel Courteix
  • David Thivel
  • Julien Verney
  • Histochem. Cell Biol..2020 Jun;10.1007/s00418-020-01895-5. doi: 10.1007/s00418-020-01895-5.Epub 2020-06-26.

ブロイラーニワトリのCYP3A37およびMDR1 mRNA発現レベルに及ぼすピペリンおよびケルセチンの単独またはマーボフロキサシンとの併用の効果

Effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in broiler chickens.
  • Harshad B Patel
  • Urvesh D Patel
  • Basavaraj S Mathapati
  • Chirag M Modi
  • Res. Vet. Sci..2019 Oct;126:178-183. S0034-5288(18)31589-3. doi: 10.1016/j.rvsc.2019.09.005.Epub 2019-09-12.

パラプレジンの喪失は、運動失調ではなく痙縮を促進する

Loss of paraplegin drives spasticity rather than ataxia in a cohort of 241 patients with .
  • Giulia Coarelli
  • Rebecca Schule
  • Bart P C van de Warrenburg
  • Peter De Jonghe
  • Claire Ewenczyk
  • Andrea Martinuzzi
  • Matthis Synofzik
  • Elisa G Hamer
  • Jonathan Baets
  • Mathieu Anheim
  • Ludger Schöls
  • Tine Deconinck
  • Pegah Masrori
  • Bertrand Fontaine
  • Thomas Klockgether
  • Maria Grazia D'Angelo
  • Marie-Lorraine Monin
  • Jan De Bleecker
  • Isabelle Migeotte
  • Perrine Charles
  • Maria Teresa Bassi
  • Thomas Klopstock
  • Fanny Mochel
  • Elisabeth Ollagnon-Roman
  • Marc D'Hooghe
  • Christoph Kamm
  • Delia Kurzwelly
  • Melanie Papin
  • Claire-Sophie Davoine
  • Guillaume Banneau
  • Sophie Tezenas du Montcel
  • Danielle Seilhean
  • Alexis Brice
  • Charles Duyckaerts
  • Giovanni Stevanin
  • Alexandra Durr
  • Neurology.2019 06;92(23):e2679-e2690. WNL.0000000000007606. doi: 10.1212/WNL.0000000000007606.Epub 2019-05-08.

177Lu標識Tyr3-octreotate放射性核種治療後の腎機能モニタリングのためのラットの動的および静的小動物SPECT

Dynamic and static small-animal SPECT in rats for monitoring renal function after 177Lu-labeled Tyr3-octreotate radionuclide therapy.
  • Marleen Melis
  • Jan de Swart
  • Monique de Visser
  • Saskia C Berndsen
  • Stuart Koelewijn
  • Roelf Valkema
  • Otto C Boerman
  • Eric P Krenning
  • Marion de Jong
  • J. Nucl. Med..2010 Dec;51(12):1962-8. jnumed.110.080143. doi: 10.2967/jnumed.110.080143.Epub 2010-11-15.

HOXトランスクリプトアンチセンスRNAは、トリプルネガティブ乳がん細胞におけるAngiomiR-204/FAK軸を標的とすることで、血管原性模倣をアブログする

HOX Transcript Antisense RNA Abrogates Vasculogenic Mimicry by Targeting the AngiomiR-204/FAK Axis in Triple Negative Breast Cancer Cells.
  • Allan Lozano-Romero
  • Horacio Astudillo-de la Vega
  • María Cruz Del Rocío Terrones-Gurrola
  • Laurence A Marchat
  • Daniel Hernández-Sotelo
  • Yarely M Salinas-Vera
  • Rosalío Ramos-Payan
  • Macrina B Silva-Cázares
  • Stephanie I Nuñez-Olvera
  • Olga N Hernández-de la Cruz
  • César López-Camarillo
  • Noncoding RNA.2020 May;6(2). E19. doi: 10.3390/ncrna6020019.Epub 2020-05-26.

髄膜下ナルブヒネは、病院前の救急状態における急性疼痛の改善に有効であることが示された；ガンマシンチグラフィを用いた従来の筋肉内注射との比較研究

Submental nalbuphine exhibits improved efficacy in ameliorating acute pain in prehospital emergent conditions; a comparative study with conventional intramuscular using gamma scintigraphy.
  • Kushagra Khanna
  • Ritu Karwasra
  • Sandeep Choudhary
  • Deeksha Sharma
  • Nitin Sharma
  • Puja Nagpal
  • Varsha Chorsiya
  • Dhruv Kumar Nishad
  • Harvinder Popli
  • Aseem Bhatnagar
  • Injury.2020 Jun;S0020-1383(20)30538-6. doi: 10.1016/j.injury.2020.06.031.Epub 2020-06-20.

メタボロミクスは、肝胆汁酸、腸内マイクロバイオーム代謝物、細胞膜脂質の変化を明らかにするモンゴルガービルモデルにおける限界ビタミンA欠乏に関連しています

Metabolomics Reveals Altered Hepatic Bile Acids, Gut Microbiome Metabolites, and Cell Membrane Lipids Associated with Marginal Vitamin A Deficiency in a Mongolian Gerbil Model.
  • Michael R La Frano
  • Alex Brito
  • Catherine M Johnson
  • Baylee Wilhelmson
  • Bryan Gannon
  • Rob K Fanter
  • Theresa L Pedersen
  • Sherry A Tanumihardjo
  • John W Newman
  • Mol Nutr Food Res.2020 Jul;64(13):e1901319. doi: 10.1002/mnfr.201901319.Epub 2020-06-22.

ボルテゾミブまたはレナリドミドマイドによる治療を受けた新規多発性骨髄腫と診断された患者において、形態学的分類は重要な予後因子である

Morphologic Classification Is an Important Prognostic Factor in Patients with Newly Diagnosed Multiple Myeloma Treated with Bortezomib or Lenalidomide.
  • Teruhito Takakuwa
  • Taku Araki
  • Koji Nakamura
  • Tomoko Fukuyama
  • Akiko Miura
  • Yotaro Fujitani
  • Akari Hisanabe
  • Anna Kaieda
  • Erina Fukada
  • Ryosuke Yamamura
  • Ann. Clin. Lab. Sci..2020 May;50(3):333-341. 50/3/333.

経皮的電気刺激は、肝がん患者における経カテーテル動脈化学塞栓療法によって誘発される胃腸障害を改善する

Transcutaneous Electrical Acustimulation Improves Gastrointestinal Disturbances Induced by Transcatheter Arterial Chemoembolization in Patients With Liver Cancers.
  • Ying Zhu
  • Xianpeng Li
  • Jibo Ma
  • Wenyi Xu
  • Miaomiao Li
  • Yaoyao Gong
  • Bo Zhang
  • Ying Chen
  • Sun Chao
  • Qingcheng Xu
  • Lin Lin
  • Jiande D Z Chen
  • Neuromodulation.2020 May;doi: 10.1111/ner.13158.Epub 2020-05-06.

大腸がん検出のための新しいアプローチとしての非侵襲的に採取された大腸粘液中のバイオマーカー測定：スクリーニングとトリアージの意味合い

Biomarker measurement in non-invasively sampled colorectal mucus as a novel approach to colorectal cancer detection: screening and triage implications.
  • Alexandre Loktionov
  • Anet Soubieres
  • Tatiana Bandaletova
  • Nader Francis
  • Joanna Allison
  • Julian Sturt
  • Jai Mathur
  • Andrew Poullis
  • Br. J. Cancer.2020 May;10.1038/s41416-020-0893-8. doi: 10.1038/s41416-020-0893-8.Epub 2020-05-13.

ジンセノサイドRg1のうつ病に対する保護効果は、海馬のアストロサイトのギャップジャンクション機能に利益をもたらす可能性がある

The protective effect of ginsenoside Rg1 on depression may benefit from the gap junction function in hippocampal astrocytes.
  • Yu-Xia Lou
  • Zhen-Zhen Wang
  • Cong-Yuan Xia
  • Zheng Mou
  • Qian Ren
  • Dan-Dan Liu
  • Xin Zhang
  • Nai-Hong Chen
  • Eur. J. Pharmacol..2020 Jun;:173309. S0014-2999(20)30401-5. doi: 10.1016/j.ejphar.2020.173309.Epub 2020-06-26.

抜歯による三叉神経中脳ニューロンの神経変性は、3×Tg-ADモデルマウスにおけるアルツハイマー病の進行を誘発する

Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer's Disease in 3×Tg-AD Model Mice.
  • Tetsuya Goto
  • Eriko Kuramoto
  • Ashis Dhar
  • Rachel P-H Wang
  • Haruka Seki
  • Haruki Iwai
  • Atsushi Yamanaka
  • Shin-Ei Matsumoto
  • Hiromitsu Hara
  • Makoto Michikawa
  • Yasumasa Ohyagi
  • Wai K Leung
  • Raymond C-C Chang
  • J. Alzheimers Dis..2020 Jul;JAD200257. doi: 10.3233/JAD-200257.Epub 2020-07-09.

痙攣のコントロールと不安。若年性ミオクロニーてんかん患者における社会的適応にはどの因子が大きな役割を果たしているのか？

Seizure control and anxiety: Which factor plays a major role in social adjustment in patients with Juvenile Myoclonic Epilepsy?
  • Maria Luisa Paiva
  • Ellen Marise Lima
  • Isabelle Bimbatti Siqueira
  • Patricia Rzezak
  • Camila Koike
  • Sylvie P Moschetta
  • Silvia Vincentiis
  • Rudá Alessi
  • Tatiana Cohab Khafif
  • Melanie Mendoza
  • Kette D Valente
  • Seizure.2020 Jul;80:234-239. S1059-1311(20)30196-5. doi: 10.1016/j.seizure.2020.06.033.Epub 2020-07-02.

また、外来菌根植物は、新規な場所での共同導入された菌根菌や在来菌根菌との相互作用能力が異なる

Alien ectomycorrhizal plants differ in their ability to interact with co-introduced and native ectomycorrhizal fungi in novel sites.
  • Lukáš Vlk
  • Leho Tedersoo
  • Tomáš Antl
  • Tomáš Větrovský
  • Kessy Abarenkov
  • Jan Pergl
  • Jana Albrechtová
  • Miroslav Vosátka
  • Petr Baldrian
  • Petr Pyšek
  • Petr Kohout
  • ISME J.2020 Jun;10.1038/s41396-020-0692-5. doi: 10.1038/s41396-020-0692-5.Epub 2020-06-04.

また、セレコキシブによる FKBP5 を介した PD-L1 のダウンレギュレーションは、悪性神経膠腫モデルにおける PD-1 ブロッキングの抗腫瘍効果を増強することが明らかになった

Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model.
  • Izumi Yamaguchi
  • Kohei Nakajima
  • Kenji Shono
  • Yoshifumi Mizobuchi
  • Toshitaka Fujihara
  • Eiji Shikata
  • Tadashi Yamaguchi
  • Keiko Kitazato
  • Oltea Sampetrean
  • Hideyuki Saya
  • Yasushi Takagi
  • Neurooncol Adv.2020 Jan-Dec;2(1):vdz058. vdz058. doi: 10.1093/noajnl/vdz058.Epub 2019-12-26.

植物由来の天然生体分子ピシンは、神経芽腫細胞のミトコンドリアにおけるメナジオン誘発性酸化ストレスを抑制する

Plant-Derived Natural Biomolecule Picein Attenuates Menadione Induced Oxidative Stress on Neuroblastoma Cell Mitochondria.
  • Kavindra Kumar Kesari
  • Anupam Dhasmana
  • Shruti Shandilya
  • Neeraj Prabhakar
  • Ahmed Shaukat
  • Jinze Dou
  • Jessica M Rosenholm
  • Tapani Vuorinen
  • Janne Ruokolainen
  • Antioxidants (Basel).2020 Jun;9(6). E552. doi: 10.3390/antiox9060552.Epub 2020-06-25.

ミトコンドリア電圧依存性アニオン選択的チャネルの3つのアイソフォームのN末端ドメインの折り畳み構造と膜親和性

Folded Structure and Membrane Affinity of the N-Terminal Domain of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion-Selective Channel.
  • Giorgia Manzo
  • Ilaria Serra
  • Andrea Magrí
  • Mariano Casu
  • Vito De Pinto
  • Matteo Ceccarelli
  • Mariano Andrea Scorciapino
  • ACS Omega.2018 Sep;3(9):11415-11425. doi: 10.1021/acsomega.8b01536.Epub 2018-09-19.

ヒト内頸静脈壁の寸法、コンプライアンス、拡張性の遺伝性

Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall.
  • Adam Domonkos Tarnoki
  • Andrea Agnes Molnar
  • David Laszlo Tarnoki
  • Levente Littvay
  • Emanuela Medda
  • Corrado Fagnani
  • Antonio Arnofi
  • Filippo Farina
  • Claudio Baracchini
  • Giorgio Meneghetti
  • Giacomo Pucci
  • Giuseppe Schillaci
  • Maria Antonietta Stazi
  • György L Nadasy
  • PLoS ONE.2018;13(3):e0192948. PONE-D-17-23431. doi: 10.1371/journal.pone.0192948.Epub 2018-03-21.

メニエール病における栄養キノコ治療と：神経炎症と抗神経変性における治療的介入のための根拠

Nutritional Mushroom Treatment in Meniere's Disease with : A Rationale for Therapeutic Intervention in Neuroinflammation and Antineurodegeneration.
  • Maria Scuto
  • Paola Di Mauro
  • Maria Laura Ontario
  • Chiara Amato
  • Sergio Modafferi
  • Domenico Ciavardelli
  • Angela Trovato Salinaro
  • Luigi Maiolino
  • Vittorio Calabrese
  • Int J Mol Sci.2019 Dec;21(1). E284. doi: 10.3390/ijms21010284.Epub 2019-12-31.

アリイブリオサルモニダ由来の第二鉄取り込み調節因子(Fur)の生化学的特徴付け。結合研究と構造モデル化によるDNA配列特異性のマッピング

Biochemical characterization of ferric uptake regulator (Fur) from Aliivibrio salmonicida. Mapping the DNA sequence specificity through binding studies and structural modelling.
  • Kristel Berg
  • Hege Lynum Pedersen
  • Ingar Leiros
  • Biometals.2020 Jul;10.1007/s10534-020-00240-6. doi: 10.1007/s10534-020-00240-6.Epub 2020-07-09.

Mycobacterium avium complex pulmonary diseaseの進行性空洞に対する特徴的な胸部CT所見：レトロスペクティブコホート研究

Characteristic chest CT findings for progressive cavities in Mycobacterium avium complex pulmonary disease: a retrospective cohort study.
  • Yohei Oshitani
  • Seigo Kitada
  • Ryuya Edahiro
  • Kazuyuki Tsujino
  • Hiroyuki Kagawa
  • Kenji Yoshimura
  • Keisuke Miki
  • Mari Miki
  • Hiroshi Kida
  • Respir. Res..2020 Jan;21(1):10. 10.1186/s12931-020-1273-x. doi: 10.1186/s12931-020-1273-x.Epub 2020-01-08.

親水性と従来のサンドブラスト、酸エッチングを施したインプラント表面のインプラント安定性と生存率。系統的レビューとメタアナリシス

Implant stability and survival rates of a hydrophilic versus a conventional sandblasted, acid-etched implant surface: Systematic review and meta-analysis.
  • Huthayfa N S Almassri
  • Yihui Ma
  • Zhang Dan
  • Zhang Ting
  • Yuting Cheng
  • Xiaohong Wu
  • J Am Dent Assoc.2020 06;151(6):444-453. S0002-8177(20)30162-8. doi: 10.1016/j.adaj.2020.03.002.

フロセミド排泄ストレス試験は、敗血症後のマウスの死亡率を予測し、バソプレシン投与時のフロセミド排泄ストレス試験を上回る

A Furosemide Excretion Stress Test Predicts Mortality in Mice After Sepsis and Outperforms the Furosemide Stress Test During Vasopressin Administration.
  • Jonathan M Street
  • Tiffany R Bellomo
  • Erik H Koritzinsky
  • Hiroshi Kojima
  • Peter S T Yuen
  • Robert A Star
  • Crit Care Explor.2020 May;2(5):e0112. doi: 10.1097/CCE.0000000000000112.Epub 2020-05-07.

南西大西洋沿岸のピレスロイド系殺虫剤。生物指標としてのギアナイルカ（Sotalia guianensis）

Pyrethroid insecticides along the Southwestern Atlantic coast: Guiana dolphin (Sotalia guianensis) as a bioindicator.
  • Lara G Vidal
  • Monizze Vannuci-Silva
  • Mariana B Alonso
  • Maria L Feo
  • Cayo Corcellas
  • Tatiana L Bisi
  • Leonardo Flach
  • Ana Bernadete Lima Fragoso
  • Flávio J Lima Silva
  • Vítor Luz Carvalho
  • Ana Carolina O de Meirelles
  • Camila Domit
  • Lupércio A Barbosa
  • Marta J Cremer
  • Alexandre F Azevedo
  • João Paulo M Torres
  • Olaf Malm
  • José Lailson-Brito
  • Ethel Eljarrat
  • Sci. Total Environ..2020 Aug;728:138749. S0048-9697(20)32266-X. doi: 10.1016/j.scitotenv.2020.138749.Epub 2020-04-17.

未治療の多発性骨髄腫におけるメルファラン、プレドニゾロン、ボルテゾミブの最適化を目的とした無作為化第II相試験（JCOG1105

Randomised phase II study to optimise melphalan, prednisolone, and bortezomib in untreated multiple myeloma (JCOG1105).
  • Dai Maruyama
  • Shinsuke Iida
  • Gakuto Ogawa
  • Noriko Fukuhara
  • Sachiko Seo
  • Kana Miyazaki
  • Makoto Yoshimitsu
  • Junya Kuroda
  • Norifumi Tsukamoto
  • Hideki Tsujimura
  • Akira Hangaishi
  • Takahiro Yamauchi
  • Takahiko Utsumi
  • Ishikazu Mizuno
  • Yasushi Takamatsu
  • Yasuyuki Nagata
  • Koichiro Minauchi
  • Eiichi Ohtsuka
  • Ichiro Hanamura
  • Shinichiro Yoshida
  • Satoshi Yamasaki
  • Youko Suehiro
  • Yutaro Kamiyama
  • Kunihiro Tsukasaki
  • Hirokazu Nagai
  • Br. J. Haematol..2020 Jun;doi: 10.1111/bjh.16878.Epub 2020-06-24.

Plantamajoside は、Akt/NF-κB 経路の不活性化を介して、ラット糸球体中膜細胞における高グルコース誘発性酸化ストレス、炎症、細胞外マトリックス蓄積を抑制します

Plantamajoside inhibits high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in rat glomerular mesangial cells through the inactivation of Akt/NF-κB pathway.
  • Dongmei Xiao
  • Rui Yang
  • Li Gong
  • Yawei Zhang
  • Yongli Xie
  • Shenjue Ni
  • J. Recept. Signal Transduct. Res..2020 Jul;:1-8. doi: 10.1080/10799893.2020.1784939.Epub 2020-07-01.

小児におけるNF1様視路グリオーマ：この特異的な症例の臨床的および分子的特徴付け

NF1-like optic pathway gliomas in children: clinical and molecular characterization of this specific presentation.
  • María Jesús Lobón-Iglesias
  • Ingrid Laurendeau
  • Léa Guerrini-Rousseau
  • Arnault Tauziède-Espariat
  • Audrey Briand-Suleau
  • Pascale Varlet
  • Dominique Vidaud
  • Michel Vidaud
  • Laurence Brugieres
  • Jacques Grill
  • Eric Pasmant
  • Neurooncol Adv.2020 Jul;2(Suppl 1):i98-i106. vdz054. doi: 10.1093/noajnl/vdz054.Epub 2019-12-20.

移植前にWT1発現が低かった急性骨髄性白血病患者を対象とした末梢血幹細胞移植のミロアブレーション（CyTBI、BuCy）対低強度化（FluBu2TBI400）の比較

Comparison of myeloablative (CyTBI, BuCy) versus reduced-intensity (FluBu2TBI400) peripheral blood stem cell transplantation in acute myeloid leukemia patients with pre-transplant low WT1 expression.
  • Silvia Park
  • Gi June Min
  • Sung Soo Park
  • Seung-Ah Yahng
  • Young-Woo Jeon
  • Seung-Hwan Shin
  • Jae-Ho Yoon
  • Sung-Eun Lee
  • Byung Sik Cho
  • Ki-Seong Eom
  • Yoo-Jin Kim
  • Seok Lee
  • Chang-Ki Min
  • Seok-Goo Cho
  • Dong-Wook Kim
  • Jong Wook Lee
  • Hee-Je Kim
  • Biol. Blood Marrow Transplant..2020 Jul;S1083-8791(20)30415-8. doi: 10.1016/j.bbmt.2020.07.006.Epub 2020-07-10.

乳がん化学療法の選択肢。ヌクレオ脂質ナノシステム内に配置されたマルチターゲットルテニウム(III)錯体の前臨床検証に関する一般的な概要

Breast Cancer Chemotherapeutic Options: A General Overview on the Preclinical Validation of a Multi-Target Ruthenium(III) Complex Lodged in Nucleolipid Nanosystems.
  • Maria Grazia Ferraro
  • Marialuisa Piccolo
  • Gabriella Misso
  • Francesco Maione
  • Daniela Montesarchio
  • Michele Caraglia
  • Luigi Paduano
  • Rita Santamaria
  • Carlo Irace
  • Cells.2020 Jun;9(6). E1412. doi: 10.3390/cells9061412.Epub 2020-06-05.

韓国人患者における軽鎖近位尿細管症の臨床病理学的特徴と免疫グロブリン軽鎖の免疫組織化学染色の診断有用性

Clinicopathological characteristics of light chain proximal tubulopathy in Korean patients and the diagnostic usefulness of immunohistochemical staining for immunoglobulin light chain.
  • Minsun Jung
  • Youngeun Lee
  • Hajeong Lee
  • Kyung Chul Moon
  • BMC Nephrol.2020 Apr;21(1):146. 10.1186/s12882-020-01813-w. doi: 10.1186/s12882-020-01813-w.Epub 2020-04-23.

早期のM-タンパク質動態は再発・難治性多発性骨髄腫患者の無増悪生存率を予測する

Early M-Protein Dynamics Predicts Progression-Free Survival in Patients With Relapsed/Refractory Multiple Myeloma.
  • Xiaoyu Yan
  • Xu Steven Xu
  • Katja C Weisel
  • Maria-Victoria Mateos
  • Pieter Sonneveld
  • Meletios A Dimopoulos
  • Saad Zafar Usmani
  • Nizar J Bahlis
  • Thomas Puchalski
  • Jon Ukropec
  • Kevin Bellew
  • Qi Ming
  • Steven Sun
  • Honghui Zhou
  • Clin Transl Sci.2020 Jun;doi: 10.1111/cts.12836.Epub 2020-06-25.

AAVα-シヌクレインを用いたパーキンソン病モデルラットにおけるα-シヌクレイン誘発性変化の電気生理学的測定による分類

Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson's disease using electrophysiological measurements of visual processing.
  • Freja Gam Østergaard
  • Marc M Himmelberg
  • Bettina Laursen
  • Hartwig R Siebner
  • Alex R Wade
  • Kenneth Vielsted Christensen
  • Sci Rep.2020 Jul;10(1):11869. 10.1038/s41598-020-68808-3. doi: 10.1038/s41598-020-68808-3.Epub 2020-07-17.

隣接する多発性歯肉後退の治療における修正冠状先進フラップ単独または血小板リッチフィブリン膜との併用の臨床評価：6ヶ月間の研究

Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study.
  • Sofia Aroca
  • Tibor Keglevich
  • Bruno Barbieri
  • Istvan Gera
  • Daniel Etienne
  • J. Periodontol..2009 Feb;80(2):244-52. 10.1902/jop.2009.080253. doi: 10.1902/jop.2009.080253 .

エチオピア北西部デンビアの農村部に住む5歳未満の子どもたちにおける一般的な消化器症状と関連因子。エチオピア北西部デンビアの農村部における5歳未満児の一般的な消化器症状と関連因子：コミュニティベースの横断的調査

Common Gastrointestinal Symptoms and Associated Factors Among Under-5 Children in Rural Dembiya, Northwest Ethiopia: A Community-Based Cross-Sectional Study.
  • Zemichael Gizaw
  • Ayenew Addisu
  • Destaye Guadie
  • Environ Health Insights.2020;14:1178630220927361. 10.1177_1178630220927361. doi: 10.1177/1178630220927361.Epub 2020-06-17.

細胞外容積の状態は、糖尿病性腎疾患におけるSGLT2阻害薬ダパグリフロジンに対する体液反応を予測する

The extracellular volume status predicts body fluid response to SGLT2 inhibitor dapagliflozin in diabetic kidney disease.
  • Ken Ohara
  • Takahiro Masuda
  • Masato Morinari
  • Mari Okada
  • Atsushi Miki
  • Saki Nakagawa
  • Takuya Murakami
  • Kentaro Oka
  • Maki Asakura
  • Yasuharu Miyazawa
  • Akito Maeshima
  • Tetsu Akimoto
  • Osamu Saito
  • Daisuke Nagata
  • Diabetol Metab Syndr.2020;12:37. 545. doi: 10.1186/s13098-020-00545-z.Epub 2020-05-01.

急性骨髄性白血病患者を対象に，グラゼギブと低用量シタラビンで治療した場合の治療反応に応じた生存期間の転帰と臨床的有用性

Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy.
  • Jorge E Cortes
  • Florian H Heidel
  • Walter Fiedler
  • B Douglas Smith
  • Tadeusz Robak
  • Pau Montesinos
  • Anna Candoni
  • Brian Leber
  • Mikkael A Sekeres
  • Daniel A Pollyea
  • Roxanne Ferdinand
  • Weidong Wendy Ma
  • Thomas O'Brien
  • Ashleigh O'Connell
  • Geoffrey Chan
  • Michael Heuser
  • J Hematol Oncol.2020 Jul;13(1):92. 10.1186/s13045-020-00929-8. doi: 10.1186/s13045-020-00929-8.Epub 2020-07-14.

オピオイド過剰摂取死亡率と関連した州のナロキソン入手法の地域的変動-観察研究（STROBE準拠）

Regional variation in states' naloxone accessibility laws in association with opioid overdose death rates-Observational study (STROBE compliant).
  • Hyo-Sun You
  • Jane Ha
  • Cyra-Y Kang
  • Leeseul Kim
  • Jinah Kim
  • Jay J Shen
  • Seong-Min Park
  • Sung-Youn Chun
  • Jinwook Hwang
  • Takashi Yamashita
  • Se Won Lee
  • Georgia Dounis
  • Yong-Jae Lee
  • Dong-Hun Han
  • David Byun
  • Ji Won Yoo
  • Hee-Taik Kang
  • Medicine (Baltimore).2020 May;99(22):e20033. 00005792-202005290-00018. doi: 10.1097/MD.0000000000020033.

CCND1およびMYC転座を有する"ダブルヒット"マントル細胞リンパ腫がリツキシマブ・ベンダムスチン・シタラビン（R-BAC）およびイブルチニブに再発/難治した1例

A case of "double hit" mantle cell lymphoma carrying CCND1 and MYC translocations relapsed/refractory to rituximab bendamustine cytarabine (R-BAC) and ibrutinib.
  • Greta Scapinello
  • Marcello Riva
  • Antonio Branca
  • Marco Pizzi
  • Laura Bonaldi
  • Annalisa Martines
  • Sabrina Manni
  • Andrea Visentin
  • Livio Trentin
  • Gianpietro Semenzato
  • Carmela Gurrieri
  • Francesco Piazza
  • Ann. Hematol..2020 Jul;10.1007/s00277-020-04178-0. doi: 10.1007/s00277-020-04178-0.Epub 2020-07-15.

フォローアップ研究。抗生物質を含浸させたポリメチルメタクリレートプレートと組織エキスパンダーの同時交換を用いた感染した人工乳房再建のワンステップサルベージ

Follow-Up Study: One-Step Salvage of Infected Prosthetic Breast Reconstructions Using Antibiotic-Impregnated Polymethylmethacrylate Plates and Concurrent Tissue Expander Exchange.
  • Amy S Xue
  • Angela S Volk
  • Valerie L DeGregorio
  • Kevin T Jubbal
  • Jamal M Bullocks
  • Shayan A Izaddoost
  • Plast. Reconstr. Surg..2020 Feb;145(2):240e-250e. 00006534-202002000-00005. doi: 10.1097/PRS.0000000000006501.

子どもの食事にバイオ強化されたオレンジ色の肉付きサツマイモを取り入れようとする意思の予測因子．ケニアの農村部におけるフィールド情報実験

Predictors of Intention to Integrate Biofortified Orange-fleshed Sweetpotato in Child Feeding: A Field Information Experiment in Rural Kenya.
  • Carl Johan Lagerkvist
  • Janet Mwende Mutiso
  • Julius Juma Okello
  • Penina Muoki
  • Willis Oluoch-Kosura
  • Simon Heck
  • Ecol Food Nutr.2020 May;:1-24. doi: 10.1080/03670244.2020.1759576.Epub 2020-05-14.

ポーランド産のヘマトファガウススピントゥルニクスミョウティダニ（Acari: Mesostigmata）とその宿主であるコウモリ（Yangochiroptera: Vespertilionidae）のBartonellaとRickettsia感染症について調べた

Bartonella and Rickettsia Infections in Haematophagous Spinturnix myoti Mites (Acari: Mesostigmata) and their Bat Host, Myotis myotis (Yangochiroptera: Vespertilionidae), from Poland.
  • Agnieszka Szubert-Kruszyńska
  • Joanna Stańczak
  • Stella Cieniuch
  • Edyta Podsiadły
  • Tomasz Postawa
  • Jerzy Michalik
  • Microb. Ecol..2019 Apr;77(3):759-768. 10.1007/s00248-018-1246-5. doi: 10.1007/s00248-018-1246-5.Epub 2018-08-27.

高血圧ラットにおける内皮および心機能の変化とバイオマーカーレベルにおけるTRPV1受容体および一酸化窒素の活性化の役割

The Role of the Activation of the TRPV1 Receptor and of Nitric Oxide in Changes in Endothelial and Cardiac Function and Biomarker Levels in Hypertensive Rats.
  • Juan Carlos Torres-Narváez
  • Israel Pérez-Torres
  • Vicente Castrejón-Téllez
  • Elvira Varela-López
  • Víctor Hugo Oidor-Chan
  • Verónica Guarner-Lans
  • Álvaro Vargas-González
  • Raúl Martínez-Memije
  • Pedro Flores-Chávez
  • Etzna Zizith Cervantes-Yañez
  • Claudia Angélica Soto-Peredo
  • Gustavo Pastelín-Hernández
  • Leonardo Del Valle-Mondragón
  • Int J Environ Res Public Health.2019 09;16(19). E3576. doi: 10.3390/ijerph16193576.Epub 2019-09-25.

虚血と再灌流を受けたラット肝臓における酸化ストレスの強度のシタグリプチン依存性の違い

Sitagliptin-Dependent Differences in the Intensity of Oxidative Stress in Rat Livers Subjected to Ischemia and Reperfusion.
  • Małgorzata Trocha
  • Małgorzata Krzystek-Korpacka
  • Anna Merwid-Ląd
  • Beata Nowak
  • Małgorzata Pieśniewska
  • Piotr Dzięgiel
  • Agnieszka Gomułkiewicz
  • Przemysław Kowalski
  • Dorota Diakowska
  • Adam Szeląg
  • Tomasz Sozański
  • Oxid Med Cell Longev.2019;2019:2738605. doi: 10.1155/2019/2738605.Epub 2019-10-31.

高分解能質量分析法と理論モデルの電子タバコエアロゾル中の多機能カルボニル類と有機酸の定量への応用

Application of High-Resolution Mass Spectrometry and a Theoretical Model to the Quantification of Multifunctional Carbonyls and Organic Acids in e-Cigarette Aerosol.
  • Yichen Li
  • Amanda E Burns
  • Guy J P Burke
  • Morgan E Poindexter
  • Amy K Madl
  • Kent E Pinkerton
  • Tran B Nguyen
  • Environ. Sci. Technol..2020 05;54(9):5640-5650. doi: 10.1021/acs.est.9b07387.Epub 2020-04-23.

プロスタグランジン F は無月経乳牛の排卵前卵胞特性および人工授精あたりの妊娠に影響を与える

Prostaglandin F influences pre-ovulatory follicle characteristics and pregnancy per AI in anovular dairy cows.
  • F R Lopes
  • L M Silva
  • R Zimpel
  • A K Munhoz
  • A Vieira-Neto
  • M H C Pereira
  • M Poindexter
  • M L Gambarini
  • W W Thatcher
  • J L M Vasconcelos
  • J E P Santos
  • Theriogenology.2020 Sep;153:122-132. S0093-691X(20)30273-9. doi: 10.1016/j.theriogenology.2020.04.038.Epub 2020-05-06.

メタドン維持療法を受けている注射薬使用者におけるHIV薬物耐性変異の増加は認められない。プロスペクティブコホート研究

No Increase in HIV Drug Resistance Mutations among Injecting Drug Users on Methadone Maintenance Therapy: A Prospective Cohort Study.
  • Chunyuan Huang
  • Li Ye
  • Abu S Abdullah
  • Bingyu Liang
  • Junjun Jiang
  • Chuanyi Ning
  • Ning Zang
  • Yu Zhang
  • Yuan Yang
  • Xi Hu
  • Quanlue Yang
  • Chaolian Luo
  • Feixiang Lao
  • Huifang Liu
  • Hao Liang
  • Jiegang Huang
  • Curr. HIV Res..2020 Jul;CHR-EPUB-108100. doi: 10.2174/1570162X18666200712173630.Epub 2020-07-12.

ヒトT細胞白血病ウイルス統合における宿主タンパク質のハイジャックの構造的基盤

Structural basis of host protein hijacking in human T-cell leukemia virus integration.
  • Veer Bhatt
  • Ke Shi
  • Daniel J Salamango
  • Nicholas H Moeller
  • Krishan K Pandey
  • Sibes Bera
  • Thomas E Bohl
  • Fredy Kurniawan
  • Kayo Orellana
  • Wei Zhang
  • Duane P Grandgenett
  • Reuben S Harris
  • Anna C Sundborger-Lunna
  • Hideki Aihara
  • Nat Commun.2020 Jun;11(1):3121. 10.1038/s41467-020-16963-6. doi: 10.1038/s41467-020-16963-6.Epub 2020-06-19.

内皮足場タンパク質 ENH (Enigma Homolog Protein)は、PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)を介して、AKT1とeNOS (Endothelial NO Synthase)の脱リン酸化を促進し、血管リモデリングを促進する

Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling.
  • Jiaqi Huang
  • Changhong Cai
  • Tianyu Zheng
  • Xinyan Wu
  • Dongfei Wang
  • Kaijie Zhang
  • Bocheng Xu
  • Ruochen Yan
  • Hui Gong
  • Jie Zhang
  • Yueli Shi
  • Zhiyong Xu
  • Xue Zhang
  • Xuemin Zhang
  • Tao Shang
  • Jianhong Zhou
  • Xiaogang Guo
  • Chunlai Zeng
  • En Yin Lai
  • Changchun Xiao
  • Ju Chen
  • Shu Wan
  • Wen-Hsien Liu
  • Yuehai Ke
  • Hongqiang Cheng
  • Arterioscler. Thromb. Vasc. Biol..2020 Jul;40(7):1705-1721. doi: 10.1161/ATVBAHA.120.314172.Epub 2020-04-09.

選択的レーザー溶解により製造されたチタンの表面改質は、マイトジェン活性化プロテインキナーゼシグナル伝達経路を介して破骨細胞の分化を抑制した

Surface modification of titanium manufactured through selective laser melting inhibited osteoclast differentiation through mitogen-activated protein kinase signaling pathway.
  • Jiamin Yang
  • Xiaolin Yu
  • Zhengchuan Zhang
  • Ruogu Xu
  • Fan Wu
  • Tianlu Wang
  • Yun Liu
  • Jianglin Ouyang
  • Feilong Deng
  • J Biomater Appl.2020 Aug;35(2):169-181. doi: 10.1177/0885328220920457.Epub 2020-04-27.

腫瘍微小環境の組成と重度のサイトカイン放出症候群（CRS）は、アクシカバトゲン シロロイセルで治療された大規模B細胞リンパ腫患者の毒性に影響を与える

Tumor Microenvironment composition and severe cytokine release syndrome (CRS) Influence Toxicity in Patients with Large B Cell Lymphoma Treated with Axicabtagene Ciloleucel.
  • Rawan G Faramand
  • Michael D Jain
  • Verena Staedtke
  • Hiroshi Kotani
  • Ren-Yuan Bai
  • Kayla Reid
  • Sae Bom Lee
  • Kristen Spitler
  • Xuefeng Wang
  • Biwei Cao
  • Javier Pinilla
  • Aleksandr Lazaryan
  • Farhad Khimani
  • Bijal D Shah
  • Julio Chavez
  • Taiga Nishihori
  • Asmita Mishra
  • John E Mullinax
  • Ricardo Gonzalez
  • Mohammad Hussaini
  • Marian Dam
  • Brigett Brandjes
  • Christina A Bachmeier
  • Claudio Anasetti
  • Frederick L Locke
  • Marco L Davila
  • Clin. Cancer Res..2020 Jul;clincanres.1434.2020. doi: 10.1158/1078-0432.CCR-20-1434.Epub 2020-07-15.

私たちは皆、保健サービスを受ける権利を同じように持っている」：モザンビークにおけるナマティの法的エンパワーメント・プログラムの事例研究

'We all have the same right to have health services': a case study of Namati's legal empowerment program in Mozambique.
  • Marta Schaaf
  • Joana Falcao
  • Ellie Feinglass
  • Erin Kitchell
  • Nadja Gomes
  • Lynn Freedman
  • BMC Public Health.2020 Jul;20(1):1084. 10.1186/s12889-020-09190-7. doi: 10.1186/s12889-020-09190-7.Epub 2020-07-10.

大腸癌細胞におけるGOLPH3/AKT1/mTOR軸を介した化学療法誘発ゴルジ装置断片化の保護におけるmiR-3135bの新規な役割

A novel protective role for microRNA-3135b in Golgi apparatus fragmentation induced by chemotherapy via GOLPH3/AKT1/mTOR axis in colorectal cancer cells.
  • Stephanie I Núñez-Olvera
  • Bibiana Chávez-Munguía
  • María Cruz Del Rocío Terrones-Gurrola
  • Laurence A Marchat
  • Jonathan Puente-Rivera
  • Erika Ruíz-García
  • Alma D Campos-Parra
  • Carlos Vázquez-Calzada
  • Erik R Lizárraga-Verdugo
  • Rosalío Ramos-Payán
  • Yarely M Salinas-Vera
  • César López-Camarillo
  • Sci Rep.2020 Jun;10(1):10555. 10.1038/s41598-020-67550-0. doi: 10.1038/s41598-020-67550-0.Epub 2020-06-29.

低酸素誘導性第1因子シグナル伝達経路における遺伝子のメチル化と発現の差は、乳がん生存者におけるパクリタキセル誘発末梢神経障害と化学療法誘発神経障害性疼痛の前臨床モデルと関連していた

Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pain.
  • Kord M Kober
  • Man-Cheung Lee
  • Adam Olshen
  • Yvette P Conley
  • Marina Sirota
  • Michael Keiser
  • Marilyn J Hammer
  • Gary Abrams
  • Mark Schumacher
  • Jon D Levine
  • Christine Miaskowski
  • Mol Pain.2020 Jan-Dec;16:1744806920936502. doi: 10.1177/1744806920936502.

乳がん抑制作用を有するキノコ抽出物と化合物：培養がん細胞、腫瘍担持動物を用いた研究、臨床試験からのエビデンス

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials.
  • Jack Ho Wong
  • Tzi Bun Ng
  • Helen Hei Ling Chan
  • Qin Liu
  • Gene Chi Wai Man
  • Chris Zhiyi Zhang
  • Suzhen Guan
  • Charlene Cheuk Wing Ng
  • Evandro Fei Fang
  • Hexiang Wang
  • Fang Liu
  • Xiuyun Ye
  • Krzysztof Rolka
  • Ryno Naude
  • Shuang Zhao
  • Ou Sha
  • Chunman Li
  • Lixin Xia
  • Appl. Microbiol. Biotechnol..2020 Jun;104(11):4675-4703. 10.1007/s00253-020-10476-4. doi: 10.1007/s00253-020-10476-4.Epub 2020-04-09.

また、メタボリックシンドロームモデルマウスの脂肪組織のトランスクリプトーム解析により、疾患発症に関連する遺伝子シグネチャーを同定した

Transcriptome analysis of the adipose tissue in a mouse model of metabolic syndrome identifies gene signatures related to disease pathogenesis.
  • Dimitris Nasias
  • Katerina Dalakoura-Karagkouni
  • Despoina Vassou
  • Giorgos Papagiannakis
  • Ariadni Papadaki
  • Dimitris Kardassis
  • Genomics.2020 Jul;S0888-7543(19)31032-8. doi: 10.1016/j.ygeno.2020.06.053.Epub 2020-07-08.

COMPASS試験では、血栓透過性は吸引血栓摘出術のファーストパス成功と関連している

Clot perviousness is associated with first pass success of aspiration thrombectomy in the COMPASS trial.
  • Maxim Mokin
  • Muhammad Waqas
  • Johanna Fifi
  • Reade De Leacy
  • David Fiorella
  • Elad I Levy
  • Kenneth Snyder
  • Ricardo Hanel
  • Keith Woodward
  • Imran Chaudry
  • Ansaar T Rai
  • Donald Frei
  • Josser E Delgado Almandoz
  • Michael Kelly
  • Adam S Arthur
  • Blaise W Baxter
  • Joey English
  • Italo Linfante
  • Kyle M Fargen
  • Aquilla Turk
  • Adnan H Siddiqui
  • J Mocco
  • J Neurointerv Surg.2020 Jul;neurintsurg-2020-016434. doi: 10.1136/neurintsurg-2020-016434.Epub 2020-07-17.

血管透過性のダウンレギュレーションと炎症性・酸化性障害の保護を介した敗血症関連急性肺・腎障害に対するマンギフェリンの治療効果

Therapeutic effects of mangiferin on sepsis-associated acute lung and kidney injuries via the downregulation of vascular permeability and protection of inflammatory and oxidative damages.
  • Dong Zhang
  • Shasha Han
  • Yue Zhou
  • Boyang Qi
  • Xiaozhi Wang
  • Eur J Pharm Sci.2020 Jun;152:105400. S0928-0987(20)30189-5. doi: 10.1016/j.ejps.2020.105400.Epub 2020-06-12.

前立腺特異抗原値が上昇した高齢男性患者の病理組織学、薬物療法、前立腺悪性腫瘍の予測因子-プロスペクティブ研究

Histopathology, pharmacotherapy, and predictors of prostatic malignancy in elderly male patients with raised prostate-specific antigen levels - A prospective study.
  • Dhinesh Kumar Mathaiyan
  • Satya Prakash Tripathi
  • Jeffrey Pradeep Raj
  • Bodapati Sivaramakrishna
  • Urol Ann.2020 Apr-Jun;12(2):132-137. UA-12-132. doi: 10.4103/UA.UA_68_19.Epub 2020-04-14.

ハイスループット毒素生産戦略と組み合わせたベノミクスアプローチにより、最初のベノミクス由来メラノコルチン受容体アゴニストが同定された

A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
  • Steve Reynaud
  • Justyna Ciolek
  • Michel Degueldre
  • Natalie J Saez
  • Ana Filipa Sequeira
  • Yoan Duhoo
  • Joana L A Brás
  • Hervé Meudal
  • Miguel Cabo Díez
  • Victoria Fernández Pedrosa
  • Marion Verdenaud
  • Julia Boeri
  • Oscar Pereira Ramos
  • Frédéric Ducancel
  • Margot Vanden Driessche
  • Rudy Fourmy
  • Aude Violette
  • Grégory Upert
  • Gilles Mourier
  • Annette G Beck-Sickinger
  • Karin Mörl
  • Céline Landon
  • Carlos M G A Fontes
  • Rebeca Miñambres Herráiz
  • Ricardo C Rodríguez de la Vega
  • Steve Peigneur
  • Jan Tytgat
  • Loïc Quinton
  • Edwin De Pauw
  • Renaud Vincentelli
  • Denis Servent
  • Nicolas Gilles
  • J. Med. Chem..2020 Jul;doi: 10.1021/acs.jmedchem.0c00485.Epub 2020-07-16.

希少な進行性前立腺がん変異型-腺扁平上皮がん、多形巨細胞がん、および肉腫性がん：19例の解析

Gene Fusion Characterization of Rare Aggressive Prostate Cancer Variants - Adenosquamous Carcinoma, Pleomorphic Giant Cell Carcinoma, and Sarcomatoid Carcinoma: An Analysis of 19 Cases.
  • Mohamed Alhamar
  • Tudor Vladislav
  • Steven C Smith
  • Yuan Gao
  • Liang Cheng
  • Laura A Favazza
  • Ali M Alani
  • Michael M Ittmann
  • Nicole D Riddle
  • Lisa J Whiteley
  • Nilesh S Gupta
  • Shannon Carskadon
  • Juan C Gomez-Gelvez
  • Dhananjay A Chitale
  • Nallasivam Palanisamy
  • Ondrej Hes
  • Kiril Trpkov
  • Sean R Williamson
  • Histopathology.2020 Jul;doi: 10.1111/his.14205.Epub 2020-07-08.

逆相高速液体クロマトグラフィーとパルスアンペロメトリック検出を組み合わせた、白人参中の6つの非極性ジンセノサイドの同時定量

Simultaneous quantification of six nonpolar ginsenosides in white ginseng by reverse-phase high-performance liquid chromatography coupled with integrated pulsed amperometric detection.
  • Hyeyoung Song
  • Kyung-Won Song
  • Seon-Pyo Hong
  • J Ginseng Res.2020 Jul;44(4):563-569. S1226-8453(19)30001-6. doi: 10.1016/j.jgr.2019.07.002.Epub 2019-07-26.

酸性スフィンゴミエリン酵素の直接かつ特異的な阻害剤である低分子ARC39のin vitroでの特性評価

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro.
  • Eyad Naser
  • Stephanie Kadow
  • Fabian Schumacher
  • Zainelabdeen H Mohamed
  • Christian Kappe
  • Gabriele Hessler
  • Barbara Pollmeier
  • Burkhard Kleuser
  • Christoph Arenz
  • Katrin Anne Becker
  • Erich Gulbins
  • Alexander Carpinteiro
  • J. Lipid Res..2020 Jun;61(6):896-910. jlr.RA120000682. doi: 10.1194/jlr.RA120000682.Epub 2020-03-10.

血漿中および気管支肺胞液中の IL-17A および IL-35 のレベルの上昇は、非小細胞肺がん患者におけるチェックポイント阻害剤肺炎と関連している

Elevated levels of IL-17A and IL-35 in plasma and bronchoalveolar lavage fluid are associated with checkpoint inhibitor pneumonitis in patients with non-small cell lung cancer.
  • Yi Na Wang
  • Dan Feng Lou
  • Dan Yang Li
  • Wei Jiang
  • Jing Yin Dong
  • Wei Gao
  • Hong Chao Chen
  • Oncol Lett.2020 Jul;20(1):611-622. OL-0-0-11618. doi: 10.3892/ol.2020.11618.Epub 2020-05-13.

緑膿菌を標的とした工学的低分子ピリンの免疫増強：免疫情報学的調査と積極的な免疫化の組み合わせ

Immunopotentiation of the engineered low-molecular-weight pilin targeting Pseudomonas aeruginosa: A combination of immunoinformatics investigation and active immunization.
  • Yasaman Ahmadbeigi
  • Alireza Salimi Chirani
  • Neda Soleimani
  • Mehdi Mahdavi
  • Mehdi Goudarzi
  • Mol. Immunol..2020 Aug;124:70-82. S0161-5890(20)30350-3. doi: 10.1016/j.molimm.2020.05.009.Epub 2020-06-12.

膵頭十二指腸摘術後の術前赤血球平均コルプスキュラー容積と感染症合併症との間に有意な関連があることを示した

Significant association between the preoperative erythrocyte mean corpuscular volume and infectious complications after pancreaticoduodenectomy.
  • Katsunori Sakamoto
  • Kohei Ogawa
  • Hitoshi Inoue
  • Mikiya Shine
  • Takashi Matsui
  • Yusuke Nishi
  • Takeshi Utsunomiya
  • Kei Tamura
  • Akihiro Takai
  • Yasutsugu Takada
  • Surg. Today.2020 Jul;10.1007/s00595-020-02083-7. doi: 10.1007/s00595-020-02083-7.Epub 2020-07-17.

サハラ以南のアフリカにおける低窒素投入条件でのトウモロコシ収量に対する気候変動の影響をモデル化する

Modelling climate change impacts on maize yields under low nitrogen input conditions in sub-Saharan Africa.
  • G N Falconnier
  • M Corbeels
  • K J Boote
  • F Affholder
  • M Adam
  • D S MacCarthy
  • A C Ruane
  • C Nendel
  • A M Whitbread
  • E Justes
  • L R Ahuja
  • F M Akinseye
  • I N Alou
  • K A Amouzou
  • S S Anapalli
  • C Baron
  • B Basso
  • F Baudron
  • P Bertuzzi
  • A J Challinor
  • Y Chen
  • D Deryng
  • M L Elsayed
  • B Faye
  • T Gaiser
  • M Galdos
  • S Gayler
  • E Gerardeaux
  • M Giner
  • B Grant
  • G Hoogenboom
  • E S Ibrahim
  • B Kamali
  • K C Kersebaum
  • S H Kim
  • M van der Laan
  • L Leroux
  • J I Lizaso
  • B Maestrini
  • E A Meier
  • F Mequanint
  • A Ndoli
  • C H Porter
  • E Priesack
  • D Ripoche
  • T Sida
  • U Singh
  • W Smith
  • A Srivastava
  • S Sinha
  • F Tao
  • P J Thorburn
  • D Timlin
  • B Traore
  • T Twine
  • H Webber
  • Glob Chang Biol.2020 Jul;doi: 10.1111/gcb.15261.Epub 2020-07-06.

膀胱癌に対する根治的膀胱摘出術後の補助化学療法のタイミングが患者の生存に及ぼす影響

Impact of timing of adjuvant chemotherapy following radical cystectomy for bladder cancer on patient survival.
  • Camilla M Grunewald
  • Alina Henn
  • Matthew D Galsky
  • Elizabeth R Plimack
  • Lauren C Harshman
  • Evan Y Yu
  • Simon J Crabb
  • Sumanta K Pal
  • Ajjai Shivaram Alva
  • Thomas Powles
  • Ugo De Giorgi
  • Neeraj Agarwal
  • Aristotelis Bamias
  • Sylvain Ladoire
  • Andrea Necchi
  • Ulka N Vaishampayan
  • Cora N Sternberg
  • Joaquim Bellmunt
  • Jack Baniel
  • Guenter Niegisch
  • Urol. Oncol..2020 Jul;S1078-1439(20)30276-3. doi: 10.1016/j.urolonc.2020.06.008.Epub 2020-07-10.

NPHS1およびTNFSF15における共通のリスクバリアントは、小児ステロイド感受性ネフローゼ症候群と関連している

Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome.
  • Xiaoyuan Jia
  • Tomohiko Yamamura
  • Rasheed Gbadegesin
  • Michelle T McNulty
  • Kyuyong Song
  • China Nagano
  • Yuki Hitomi
  • Dongwon Lee
  • Yoshihiro Aiba
  • Seik-Soon Khor
  • Kazuko Ueno
  • Yosuke Kawai
  • Masao Nagasaki
  • Eisei Noiri
  • Tomoko Horinouchi
  • Hiroshi Kaito
  • Riku Hamada
  • Takayuki Okamoto
  • Koichi Kamei
  • Yoshitsugu Kaku
  • Rika Fujimaru
  • Ryojiro Tanaka
  • Yuko Shima
  • Jiwon Baek
  • Hee Gyung Kang
  • Il-Soo Ha
  • Kyoung Hee Han
  • Eun Mi Yang
  • Asiri Abeyagunawardena
  • Brandon Lane
  • Megan Chryst-Stangl
  • Christopher Esezobor
  • Adaobi Solarin
  • Claire Dossier
  • Georges Deschênes
  • Marina Vivarelli
  • Hanna Debiec
  • Kenji Ishikura
  • Masafumi Matsuo
  • Kandai Nozu
  • Pierre Ronco
  • Hae Il Cheong
  • Matthew G Sampson
  • Katsushi Tokunaga
  • Kazumoto Iijima
  • Kidney Int..2020 Jun;S0085-2538(20)30639-6. doi: 10.1016/j.kint.2020.05.029.Epub 2020-06-14.

HIV 感染症患者におけるグローバルな炎症マーカーとして H-NMR で評価された糖タンパク質プロファイル。プロスペクティブ研究

Glycoprotein Profile Assessed by H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study.
  • Ana-Irene Malo
  • Anna Rull
  • Josefa Girona
  • Pere Domingo
  • Rocío Fuertes-Martín
  • Núria Amigó
  • Cèlia Rodríguez-Borjabad
  • Neus Martínez-Micaelo
  • Manuel Leal
  • Joaquim Peraire
  • Xavier Correig
  • Francesc Vidal
  • Lluis Masana
  • J Clin Med.2020 May;9(5). E1344. doi: 10.3390/jcm9051344.Epub 2020-05-04.

コントロールされた卵巣刺激とプロゲステロン補充は体外受精サイクルにおける膣および子宮内膜微生物叢に影響を与える：パイロット研究

Controlled ovarian stimulation and progesterone supplementation affect vaginal and endometrial microbiota in IVF cycles: a pilot study.
  • Andrea Carosso
  • Alberto Revelli
  • Gianluca Gennarelli
  • Stefano Canosa
  • Stefano Cosma
  • Fulvio Borella
  • Annalisa Tancredi
  • Carlotta Paschero
  • Lara Boatti
  • Elisa Zanotto
  • Francesca Sidoti
  • Paolo Bottino
  • Cristina Costa
  • Rossana Cavallo
  • Chiara Benedetto
  • J. Assist. Reprod. Genet..2020 Jul;10.1007/s10815-020-01878-4. doi: 10.1007/s10815-020-01878-4.Epub 2020-07-15.

アスパラギナーゼ遺伝子の発現がコナジラミに対する殺虫活性を誘発することを明らかにした

Constitutive expression of Asparaginase in Gossypium hirsutum triggers insecticidal activity against Bemisia tabaci.
  • Ambreen Gul
  • Ghulam Hussain
  • Adnan Iqbal
  • Abdul Qayyum Rao
  • Salah Ud Din
  • Aneela Yasmeen
  • Naila Shahid
  • Ammara Ahad
  • Ayesha Latif
  • Saira Azam
  • Tahir Rehman Samiullah
  • Samina Hassan
  • Ahmad Ali Shahid
  • Tayyab Husnain
  • Sci Rep.2020 Jun;10(1):8958. 10.1038/s41598-020-65249-w. doi: 10.1038/s41598-020-65249-w.Epub 2020-06-02.

染色体22q11.2欠失症候群患者における非定型多糖カプセルを有する肺炎球菌血清型10Aによる致死的圧迫性脾臓摘出後感染症。症例報告

Fatal overwhelming postsplenectomy infection due to Streptococcus pneumoniae serotype 10A with atypical polysaccharide capsule in a patient with chromosome 22q11.2 deletion syndrome: A case report.
  • Keiko Matsuoka
  • Itaru Yanagihara
  • Yukiko Kawazu
  • Maho Sato
  • Masahiro Nakayama
  • Yukiko Nakura
  • Nao Kanagawa
  • Yukihiro Akeda
  • Futoshi Fujiwara
  • Kazutoshi Itoh
  • Hiroaki Kawata
  • Makoto Takeuchi
  • J. Infect. Chemother..2019 Mar;25(3):192-196. S1341-321X(18)30236-8. doi: 10.1016/j.jiac.2018.07.015.Epub 2018-08-29.

トランスクリプトーム解析とinVivo発生との比較解析により明らかになったシグナル伝達経路の変調による網膜オルガノイド分化の改善

Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo.
  • Matthew J Brooks
  • Holly Y Chen
  • Ryan A Kelley
  • Anupam K Mondal
  • Kunio Nagashima
  • Natalia De Val
  • Tiansen Li
  • Vijender Chaitankar
  • Anand Swaroop
  • Stem Cell Reports.2019 11;13(5):891-905. S2213-6711(19)30338-8. doi: 10.1016/j.stemcr.2019.09.009.Epub 2019-10-17.

(モノ)研磨剤産業におけるナフタレンへの曝露．大気モニタリングと生物学的モニタリング

(Mono-) Exposure to Naphthalene in the Abrasives Industry: Air Monitoring and Biological Monitoring.
  • Tobias Weiss
  • Dietmar Breuer
  • Daniel Bury
  • Claudia Friedrich
  • Silke Werner
  • Mohammed Aziz
  • Thomas Hummel
  • Monika Raulf
  • Wolfgang Zschiesche
  • Kirsten Sucker
  • Dirk Pallapies
  • Jürgen Bünger
  • Thomas Brüning
  • Ann Work Expo Health.2020 Jul;wxaa062. doi: 10.1093/annweh/wxaa062.Epub 2020-07-13.

侵襲的中隔縮小療法のタイミングと閉塞性肥大型心筋症患者の転帰

Timing of invasive septal reduction therapies and outcome of patients with obstructive hypertrophic cardiomyopathy.
  • Luna Cavigli
  • Carlo Fumagalli
  • Niccolò Maurizi
  • Alessandra Rossi
  • Anna Arretini
  • Mattia Targetti
  • Silvia Passantino
  • Francesca Girolami
  • Benedetta Tomberli
  • Katia Baldini
  • Alessia Tomberli
  • David Antoniucci
  • Magdi H Yacoub
  • Niccolò Marchionni
  • Pier Luigi Stefano
  • Franco Cecchi
  • Iacopo Olivotto
  • Int. J. Cardiol..2018 Dec;273:155-161. S0167-5273(18)30575-8. doi: 10.1016/j.ijcard.2018.09.004.Epub 2018-09-05.

機能化グラフェンナノ粒子によるヒト間葉系幹細胞の細胞外マトリックス蛋白質の発現を誘導し、骨形成を促進する

Functionalized Graphene Nanoparticles Induce Human Mesenchymal Stem Cells to Express Distinct Extracellular Matrix Proteins Mediating Osteogenesis.
  • Steven D Newby
  • Tom Masi
  • Christopher D Griffin
  • William J King
  • Anna Chipman
  • Stacy Stephenson
  • David E Anderson
  • Alexandru S Biris
  • Shawn E Bourdo
  • Madhu Dhar
  • Int J Nanomedicine.2020;15:2501-2513. 245801. doi: 10.2147/IJN.S245801.Epub 2020-04-15.

インターフェロン-αおよびToll-like Receptor-3活性化誘発マウスうつ病モデルにおける海馬神経可塑性の低下

Compromised Hippocampal Neuroplasticity in the Interferon-α and Toll-like Receptor-3 Activation-Induced Mouse Depression Model.
  • Eduardo H Sanchez-Mendoza
  • Santiago Camblor-Perujo
  • Luiza Martins Nascentes-Melo
  • Egor Dzyubenko
  • Michael Fleischer
  • Tayana Silva de Carvalho
  • Linda-Isabell Schmitt
  • Markus Leo
  • Tim Hagenacker
  • Arne Herring
  • Kathy Keyvani
  • Sujoy Bera
  • Natalia Kononenko
  • Christoph Kleinschnitz
  • Dirk M Hermann
  • Mol. Neurobiol..2020 Jul;57(7):3171-3182. 10.1007/s12035-020-01927-0. doi: 10.1007/s12035-020-01927-0.Epub 2020-06-05.

ボルテゾミブとテモゾロミドの併用療法は、臨床成績が良好な膠芽腫患者の免疫反応を促進する。第1B相試験

Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study.
  • Mohummad A Rahman
  • Jorunn Brekke
  • Victoria Arnesen
  • Marianne H Hannisdal
  • Andrea G Navarro
  • Andreas Waha
  • Lars Herfindal
  • Cecilie B Rygh
  • Eirik Bratland
  • Petter Brandal
  • Judit Haasz
  • Leif Oltedal
  • Hrvoje Miletic
  • Arvid Lundervold
  • Stein A Lie
  • Dorota Goplen
  • Martha Chekenya
  • Immun Inflamm Dis.2020 Jun;doi: 10.1002/iid3.315.Epub 2020-06-24.

高額医療保険に加入している高額医療サービス利用のリスクがある炎症性腸疾患患者における医療利用パターンの変動

Variations in Health Care Utilization Patterns Among Inflammatory Bowel Disease Patients at Risk for High Medical Service Utilization Enrolled in High Deductible Health Plans.
  • Jeffrey A Berinstein
  • Shirley A Cohen-Mekelburg
  • Calen A Steiner
  • Megan McLeod
  • Mohamed Noureldin
  • John I Allen
  • Jeffrey T Kullgren
  • Akbar K Waljee
  • Peter D R Higgins
  • Inflamm. Bowel Dis..2020 Jul;izaa179. doi: 10.1093/ibd/izaa179.Epub 2020-07-17.

難治性慢性クラスター性頭痛の治療のためのオナボツリヌストキシンAの海綿体神経節への注射の非盲検、多用量、パイロット安全性試験

Open-Label, Multi-Dose, Pilot Safety Study of Injection of OnabotulinumtoxinA Toward the Otic Ganglion for the Treatment of Intractable Chronic Cluster Headache.
  • Joan Crespi
  • Daniel Bratbak
  • David W Dodick
  • Manjit Matharu
  • Ole Solheim
  • Sasha Gulati
  • Erik Magnus Berntsen
  • Erling Tronvik
  • Headache.2020 Jun;doi: 10.1111/head.13889.Epub 2020-06-25.

HPV ワクチン接種後の原因不明の有害事象は感染性単核球症と関連しているか？- デンマークの全国的なマッチドケースコントロール研究

Are unexplained adverse health events following HPV vaccination associated with infectious mononucleosis? - A Danish nationwide matched case-control study.
  • Lene Wulff Krogsgaard
  • Ida Glode Helmuth
  • Bodil Hammer Bech
  • Oleguer Plana-Ripoll
  • Tina Hovgaard Lützen
  • Hanne Thang Vestergaard
  • Karsten Dalsgaard Bjerre
  • Reimar Wernich Thomsen
  • Kåre Mølbak
  • Dorte Rytter
  • Vaccine.2020 Jul;S0264-410X(20)30843-4. doi: 10.1016/j.vaccine.2020.06.057.Epub 2020-07-02.

グロビン共役型ジグアニル酸シクラーゼYddVの速度論的解析：ヘム鉄酸化還元状態、軸方向リガンド、ヘム遠位変異が触媒作用に及ぼす影響

Kinetic analysis of a globin-coupled diguanylate cyclase, YddV: Effects of heme iron redox state, axial ligands, and heme distal mutations on catalysis.
  • Alzbeta Lengalova
  • Veronika Fojtikova-Proskova
  • Jakub Vavra
  • Václav Martínek
  • Martin Stranava
  • Toru Shimizu
  • Marketa Martinkova
  • J. Inorg. Biochem..2019 12;201:110833. S0162-0134(19)30398-8. doi: 10.1016/j.jinorgbio.2019.110833.Epub 2019-09-06.

ゴナドトロピン放出ホルモンアゴニストとホルモン補充療法の併用は、高齢者における凍結融解胚移植サイクルの生殖成績を改善しなかった：レトロスペクティブ研究

Gonadotropin-releasing hormone agonist combined with hormone replacement therapy does not improve the reproductive outcomes of frozen-thawed embryo transfer cycle in elderly patients: a retrospective study.
  • Mei Dong
  • Li Sun
  • Li Huang
  • Yanhong Yi
  • Xiqian Zhang
  • Ying Tan
  • Ge Song
  • Liling Liu
  • Fu Wei
  • Fenghua Liu
  • Reprod. Biol. Endocrinol..2020 Jul;18(1):73. 10.1186/s12958-020-00626-8. doi: 10.1186/s12958-020-00626-8.Epub 2020-07-15.

中東最古の石油精製地帯の土壌に含まれる潜在的な有害元素：供給源の配分、スペシエーション、バイオアクセス性、およびヒトの健康リスク評価

Potentially toxic elements in the Middle East oldest oil refinery zone soils: source apportionment, speciation, bioaccessibility and human health risk assessment.
  • Zeinab Mokhtarzadeh
  • Behnam Keshavarzi
  • Farid Moore
  • Franco Ajmone Marsan
  • Elio Padoan
  • Environ Sci Pollut Res Int.2020 Jul;10.1007/s11356-020-09895-7. doi: 10.1007/s11356-020-09895-7.Epub 2020-07-15.

内分泌かく乱物質の光分解のための効率的な広スペクトル駆動型炭素・酸素共添加g-CNの開発メカニズム,分解経路,DFT計算,トルエン選択的酸化

An efficient broad spectrum-driven carbon and oxygen co-doped g-CN for the photodegradation of endocrine disrupting: Mechanism, degradation pathway, DFT calculation and toluene selective oxidation.
  • Liquan Jing
  • Duidui Wang
  • Minqiang He
  • Yuanguo Xu
  • Meng Xie
  • Yanhua Song
  • Hui Xu
  • Huaming Li
  • J. Hazard. Mater..2020 Jun;401:123309. S0304-3894(20)31298-X. doi: 10.1016/j.jhazmat.2020.123309.Epub 2020-06-27.

超微細な二酸化ケイ素ナノ粒子は、酸化ストレスによって活性化されたPI3K/Aktを介したミトコンドリアおよび小胞体ストレス依存性のシグナル伝達経路を介して肺上皮細胞のアポトーシスを引き起こす

Ultrafine silicon dioxide nanoparticles cause lung epithelial cells apoptosis via oxidative stress-activated PI3K/Akt-mediated mitochondria- and endoplasmic reticulum stress-dependent signaling pathways.
  • Kuan-I Lee
  • Chin-Chuan Su
  • Kai-Min Fang
  • Chin-Ching Wu
  • Cheng-Tien Wu
  • Ya-Wen Chen
  • Sci Rep.2020 Jun;10(1):9928. 10.1038/s41598-020-66644-z. doi: 10.1038/s41598-020-66644-z.Epub 2020-06-18.

ナイジェリア、ザリアにあるAhmadu Bello University Teaching Hospitalの放射線治療・腫瘍学センターに通院している成人がん患者に見られる腫瘍学的緊急事態のパターン

Pattern of oncologic emergencies seen in adult cancer patients attending the Radiotherapy and Oncology Centre, Ahmadu Bello University Teaching Hospital, Zaria - Nigeria.
  • S A Adewuyi
  • A T Ajekigbe
  • O B Campbell
  • N H Mbibu
  • A O Oguntayo
  • A O D Kolawole
  • A Usman
  • M O A Samaila
  • S M Shehu
  • Niger Postgrad Med J.2012 Dec;19(4):208-14.

Ta および T1 膀胱癌に対する膀胱内投与の Bacillus Calmette-Guérin 対 mitomycin C.コクランレビューの要約

Intravesical Bacillus Calmette-Guérin versus mitomycin C for Ta and T1 bladder cancer: Abridged summary of the Cochrane Review.
  • Stefanie Schmidt
  • Frank Kunath
  • Bernadette Coles
  • Desiree Louise Draeger
  • Laura-Maria Krabbe
  • Rick Dersch
  • Samuel Kilian
  • Katrin Jensen
  • Philipp Dahm
  • Joerg J Meerpohl
  • Investig Clin Urol.2020 Jul;61(4):349-354. doi: 10.4111/icu.2020.61.4.349.Epub 2020-06-29.

Plasmodium falciparum Hsp70-Hsp90 組織化タンパク質 (PfHop) の生物物理学的解析により、柔軟性のあるリンカーで連結された折り畳みセグメントが特徴のモノマーが明らかになりました

Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organising protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers.
  • Stanley Makumire
  • Tawanda Zininga
  • Juha Vahokoski
  • Inari Kursula
  • Addmore Shonhai
  • PLoS ONE.2020;15(4):e0226657. PONE-D-19-33340. doi: 10.1371/journal.pone.0226657.Epub 2020-04-28.

ペルーのピウラで先天性一般化リポジストロフィーの高い有病率

High prevalence of congenital generalized lipodystrophy in Piura, Peru.
  • Nelson David Purizaca-Rosillo
  • Yamalí Elena Benites-Cóndor
  • Hugo Abarca Barriga
  • Carlos Del Águila Villar
  • Miguel Chávez Pastor
  • Littner Franco Palacios
  • Ricardo Olea Zapata
  • James Rejas Parodi
  • Luz Martinez Uceda
  • Felix Chavesta Velásquez
  • John Gamarra Vilela
  • Sebastián Arámbulo Castillo
  • Amanda Ávila Reyes
  • Intractable Rare Dis Res.2020 Feb;9(1):58-60. doi: 10.5582/irdr.2020.01004.

思春期早発症の診断：思春期早発症の診断と治療のための臨床ガイドライン

Diagnosis of precocious puberty: clinical guideline for the diagnosis and treatment of precocious puberty.
  • América L Miranda-Lora
  • Margarita Torres-Tamayo
  • Jessie N Zurita-Cruz
  • Blanca E Aguilar-Herrera
  • Raúl Calzada-León
  • Aleida J Rivera-Hernández
  • Marco A Morales-Pérez
  • Miriam M Padrón-Martínez
  • María L Ruiz-Reyes
  • Leticia M García-Morales
  • Consuelo Barrón-Uribe
  • Sletza L Arguinzoniz-Valenzuela
  • Mayra C Torres-Castañeda
  • Lorena Lizárraga-Paulin
  • Jorge A Núñez-Hernández
  • Judith Cornejo-Barrera
  • María T Vidal-González
  • María R Martínez-Alvarado
  • Elisa Nishimura-Meguro
  • Luz E Bravo-Ríos
  • Eulalia P Garrido-Magaña
  • José A Orozco-Morales
  • Patricia G Medina-Bravo
  • Ninel Coyote-Estrada
  • M Fernanda Castilla-Peón
  • Bol Med Hosp Infant Mex.2020;77(Supl 1):7-14. j77/Supl 1/7. doi: 10.24875/BMHIM.20000075.

インディアンラッセル毒由来の神経成長因子（RVV-NGFa）は、乳がん細胞に発現するTrkA受容体に高親和性で結合している。蛍光標識RVVV-NGFaの乳がん臨床診断への応用

Nerve growth factor from Indian Russell's viper venom (RVV-NGFa) shows high affinity binding to TrkA receptor expressed in breast cancer cells: Application of fluorescence labeled RVV-NGFa in the clinical diagnosis of breast cancer.
  • Taufikul Islam
  • Munmi Majumder
  • Anil Bidkar
  • Siddhartha S Ghosh
  • Rupak Mukhopadhyay
  • Yuri Utkin
  • Ashis K Mukherjee
  • Biochimie.2020 Jun;176:31-44. S0300-9084(20)30136-X. doi: 10.1016/j.biochi.2020.06.004.Epub 2020-06-23.

カドミウム誘発性生殖毒性ラットの精子指標、アクロソーム反応、精子DNA完全性に及ぼすカルポロビア・リュテアのメタノール根抽出物の影響について検討した

Effects of the methanol root extract of Carpolobia lutea on sperm indices, acrosome reaction, and sperm DNA integrity in cadmium-induced reproductive toxicity in male Wistar rats.
  • Adeniran Oluwadamilare Akinola
  • Adekunle Wahab Oyeyemi
  • Oluyemi O Daramola
  • Yinusa Raji
  • JBRA Assist Reprod.2020 Jun;doi: 10.5935/1518-0557.20200036.Epub 2020-06-08.

カベオリン-1アブレーションは、実験緑内障における網膜内損傷に対する部分的な保護とアポトーシス活性化を減少させる

Caveolin-1 Ablation Imparts Partial Protection Against Inner Retinal Injury in Experimental Glaucoma and Reduces Apoptotic Activation.
  • Mojdeh Abbasi
  • Vivek K Gupta
  • Nitin Chitranshi
  • Veer B Gupta
  • Mehdi Mirzaei
  • Yogita Dheer
  • Linda Garthwaite
  • Thiri Zaw
  • Robert G Parton
  • Yuyi You
  • Stuart L Graham
  • Mol. Neurobiol..2020 Jun;10.1007/s12035-020-01948-9. doi: 10.1007/s12035-020-01948-9.Epub 2020-06-23.

拡大された分子系統と形態学的解析から、シダ科デンシュタットリア属の進化に新たな知見が得られた

New insights into the evolution of the fern family Dennstaedtiaceae from an expanded molecular phylogeny and morphological analysis.
  • Pedro B Schwartsburd
  • Leon R Perrie
  • Patrick Brownsey
  • Lara D Shepherd
  • Hui Shang
  • David S Barrington
  • Michael A Sundue
  • Mol. Phylogenet. Evol..2020 Jun;150:106881. S1055-7903(20)30153-6. doi: 10.1016/j.ympev.2020.106881.Epub 2020-06-06.

急性視神経炎（MOVING）の最初の片側エピソードの後の Fingolimod - 無作為化、評価者盲検、活性化対照、第2相試験の予備的な結果

Fingolimod after a first unilateral episode of acute optic neuritis (MOVING) - preliminary results from a randomized, rater-blind, active-controlled, phase 2 trial.
  • Christian Albert
  • Janine Mikolajczak
  • Anja Liekfeld
  • Sophie K Piper
  • Michael Scheel
  • Hanna G Zimmermann
  • Claus Nowak
  • Jan Dörr
  • Judith Bellmann-Strobl
  • Claudia Chien
  • Alexander U Brandt
  • Friedemann Paul
  • Olaf Hoffmann
  • BMC Neurol.2020 Mar;20(1):75. 10.1186/s12883-020-01645-z. doi: 10.1186/s12883-020-01645-z.Epub 2020-03-03.

非アレルギー性およびアレルギー性ドナーのヒト初代鼻上皮細胞の物理的および免疫学的バリアー

Physical and immunological barrier of human primary nasal epithelial cells from non-allergic and allergic donors.
  • Carolin Bergougnan
  • Daniela C Dittlein
  • Elke Hümmer
  • Rosalie Riepl
  • Selina Eisenbart
  • Dominik Böck
  • Lena Griesbaum
  • Anna Weigl
  • Athanasios Damialis
  • Alexander Hartwig
  • Avidan U Neumann
  • Johannes Zenk
  • Claudia Traidl-Hoffmann
  • Stefanie Gilles
  • World Allergy Organ J.2020 Mar;13(3):100109. S1939-4551(20)30012-0. doi: 10.1016/j.waojou.2020.100109.Epub 2020-03-09.

活性化プロトロンビン複合体濃縮物は、抗凝固剤関連出血または緊急手術前の直接経口投与のためのものです。止血および血栓症の転帰

Activated prothrombin complex concentrates for direct oral anticoagulant-associated bleeding or urgent surgery: Hemostatic and thrombotic outcomes.
  • Joseph R Shaw
  • Marc Carrier
  • Dar Dowlatshahi
  • Santanu Chakraborty
  • Melanie Tokessy
  • Hakan Buyukdere
  • Lana A Castellucci
  • Thromb. Res..2020 Jul;195:21-28. S0049-3848(20)30286-3. doi: 10.1016/j.thromres.2020.06.044.Epub 2020-07-01.

子宮頸部扁平上皮癌および腺癌に対する確定的同時化学放射線療法の全生存、局所領域再発、遠隔転移：コホート研究の傾向スコアマッチング解析の前後

Overall survival, locoregional recurrence, and distant metastasis of definitive concurrent chemoradiotherapy for cervical squamous cell carcinoma and adenocarcinoma: before and after propensity score matching analysis of a cohort study.
  • Jiaqiang Zhang
  • Lei Qin
  • Ho-Min Chen
  • Han-Chuan Hsu
  • Chih-Chi Chuang
  • Dar Chen
  • Szu-Yuan Wu
  • Am J Cancer Res.2020;10(6):1808-1820. Epub 2020-06-01.

免疫浸潤の指標を組み合わせることで、高悪性度漿液性卵巣癌の生存予測に相加的な効果を示した

Combining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma.
  • Anne Montfort
  • Stephanie Owen
  • Anna M Piskorz
  • Anna Supernat
  • Luiza Moore
  • Sarwah Al-Khalidi
  • Steffen Böhm
  • Paul Pharoah
  • Jacqueline McDermott
  • Frances R Balkwill
  • James D Brenton
  • Br. J. Cancer.2020 Jun;122(12):1803-1810. 10.1038/s41416-020-0822-x. doi: 10.1038/s41416-020-0822-x.Epub 2020-04-06.

シスプラチン誘導性miR-425-3pのExosomal Transferは、オートファジーの活性化を介してNSCLCにおけるシスプラチン抵抗性をもたらす

Exosomal Transfer Of Cisplatin-Induced miR-425-3p Confers Cisplatin Resistance In NSCLC Through Activating Autophagy.
  • Yuzhu Ma
  • Daolu Yuwen
  • Jingwei Chen
  • Bingfeng Zheng
  • Jian Gao
  • Minmin Fan
  • Wenwen Xue
  • Yixuan Wang
  • Wuhao Li
  • Yongqian Shu
  • Qiang Xu
  • Yan Shen
  • Int J Nanomedicine.2019;14:8121-8132. 221383. doi: 10.2147/IJN.S221383.Epub 2019-10-07.

ラパコールおよびノルラパコール誘導体の抗菌活性および調節活性のインシリコ評価

In silico evaluation of the antibacterial and modulatory activity of lapachol and nor-lapachol derivates.
  • Fernando Gomes Figueredo
  • Ingrid T L Ramos
  • Josinete A Paz
  • Tania M S Silva
  • Celso A Camara
  • Cícera Datiane de Morais Oliveira-Tintino
  • Saulo Relison Tintino
  • Pablo Antônio Maia de Farias
  • Henrique Douglas Melo Coutinho
  • Marta Maria de F Fonteles
  • Microb. Pathog..2020 Jul;144:104181. S0882-4010(20)30468-X. doi: 10.1016/j.micpath.2020.104181.Epub 2020-04-08.

注意欠陥/多動性障害児におけるメチルフェニデートと血清成長マーカーとの関連性の予備的調査。横断的ケースコントロール研究

Preliminary Investigation of Association between Methylphenidate and Serum Growth Markers in Children with Attention-Deficit/Hyperactivity Disorder: A Cross-Sectional Case-Control Study.
  • Woo Jin Kim
  • Young Rong Bang
  • Je-Wook Kang
  • Jae Ho Yoo
  • Seong Hwan Kim
  • Jae Hong Park
  • Soa Chongsonyon Chongsin Uihak.2020 Jul;31(3):154-160. JKACAP-31-154. doi: 10.5765/jkacap.200014.

変換療法に関する独立法医学専門家グループの声明

Statement of the Independent Forensic Expert Group on Conversion Therapy.
  • Djordje Alempijevic
  • Rusudan Beriashvili
  • Jonathan Beynon
  • Djordje Alempijevic Petersen
  • Bettina Birmanns
  • Marie Brasholt
  • Juliet Cohen
  • Djordje Alempijevic Petersen
  • Maximo Duque
  • Pierre Duterte
  • Adriaan Van Es
  • Ravindra Fernando
  • Sebnem Korur Fincanci
  • Steen Holger Hansen
  • Sana Hamzeh
  • Lilla Hardi
  • Michele Heisler
  • Vincent Iacopino
  • Peter Mygind Leth
  • James Lin
  • Said Louahlia
  • Hege Luytkis
  • Said Louahlia
  • Maria-Dolores Morcillo-Mendez
  • Alejandro Moreno
  • Valeria Moscoso
  • Resmiye Oral
  • Onder Ozkalipci
  • Jason Payne-James
  • Jose Quiroga
  • Onder Ozkalipci
  • Hernan Reyes
  • Sidsel Rogde
  • Antti Sajantilla
  • Onder Ozkalipci
  • Matthis Schick
  • Agis Terzidis
  • Jorgen Lange Thomsen
  • Morris Tidball-Binz
  • Felicitas Treue
  • Peter Vanezis
  • Duarte Nuno Viera
  • Torture.2020;30(1):66-78. doi: 10.7146/torture.v30i1.119654.

クルクミンとメトホルミンの組み合わせは、LNCaP前立腺癌細胞株において、細胞周期に影響を与えずに細胞増殖を抑制し、アポトーシスを誘導する

Combination of Curcumin and Metformin Inhibits Cell Growth and Induces Apoptosis without Affecting the Cell Cycle in LNCaP Prostate Cancer Cell Line.
  • Seyed Sadegh Eslami
  • Davod Jafari
  • Hamed Montazeri
  • Majid Sadeghizadeh
  • Parastoo Tarighi
  • Nutr Cancer.2020 Jul;:1-14. doi: 10.1080/01635581.2020.1783327.Epub 2020-07-13.

同種幹細胞移植後 11 日目から 20 日目までのシロリムス濃度が肝副鼻腔閉塞症候群のリスクに及ぼす影響

Effect of Sirolimus levels between days 11 and 20 after allogeneic stem cell transplantation on the risk of hepatic sinusoidal obstruction syndrome.
  • Vaibhav Agrawal
  • Praveen Ranganath
  • Kirsten D Ervin
  • Caitlin A Schmidt
  • Elizabeth A Cox
  • Robert P Nelson
  • Jennifer E Schwartz
  • Mohammad Abu Zaid
  • Rafat Abonour
  • Michael J Robertson
  • Bryan J Brinda
  • Shawn P Griffin
  • Teresa C Thakrar
  • Sherif S Farag
  • Bone Marrow Transplant..2020 Jul;10.1038/s41409-020-0987-1. doi: 10.1038/s41409-020-0987-1.Epub 2020-07-04.

米国メイン州とニュージャージー州の私有井戸世帯における飲料水のヒ素曝露量とヒ素処理による健康リスクの減少

Reduction in drinking water arsenic exposure and health risk through arsenic treatment among private well households in Maine and New Jersey, USA.
  • Qiang Yang
  • Sara V Flanagan
  • Steven Chillrud
  • James Ross
  • Wenke Zeng
  • Charles Culbertson
  • Steven Spayd
  • Lorraine Backer
  • Andrew E Smith
  • Yan Zheng
  • Sci. Total Environ..2020 May;738:139683. S0048-9697(20)33203-4. doi: 10.1016/j.scitotenv.2020.139683.Epub 2020-05-25.

エタノール、Δ(9)-テトラヒドロカンナビノール（THC）、およびそれらの組み合わせの空間記憶および認知柔軟性に対する破壊的効果

Deleterious Effects of Ethanol, Δ(9)-Tetrahydrocannabinol (THC), and Their Combination on the Spatial Memory and Cognitive Flexibility in Adolescent and Adult Male Rats in the Barnes Maze Task.
  • Ewa Gibula-Tarlowska
  • Karolina Wydra
  • Jolanta H Kotlinska
  • Pharmaceutics.2020 Jul;12(7). E654. doi: 10.3390/pharmaceutics12070654.Epub 2020-07-09.

妊娠中のサイトメガロウイルス感染症に対処するためには、血清学的検査よりも衛生管理の促進の方が良いかもしれない：方法論的評価と意思決定の分析

Hygiene promotion might be better than serological screening to deal with Cytomegalovirus infection during pregnancy: a methodological appraisal and decision analysis.
  • Agathe Billette de Villemeur
  • Pierre Tattevin
  • Louis-Rachid Salmi
  • BMC Infect. Dis..2020 Jun;20(1):418. 10.1186/s12879-020-05139-8. doi: 10.1186/s12879-020-05139-8.Epub 2020-06-16.

炎症性腸疾患における5-アミノサリチル酸の使用に関する大腸炎・クローン財団（インド）のコンセンサス声明

Colitis and Crohn's Foundation (India) consensus statements on use of 5-aminosalicylic acid in inflammatory bowel disease.
  • Ajit Sood
  • Vineet Ahuja
  • Vandana Midha
  • Saroj Kant Sinha
  • C Ganesh Pai
  • Saurabh Kedia
  • Varun Mehta
  • Sawan Bopanna
  • Philip Abraham
  • Rupa Banerjee
  • Shobna Bhatia
  • Karmabir Chakravartty
  • Sunil Dadhich
  • Devendra Desai
  • Manisha Dwivedi
  • Bhabhadev Goswami
  • Kirandeep Kaur
  • Rajeev Khosla
  • Ajay Kumar
  • Ramit Mahajan
  • S P Misra
  • Kiran Peddi
  • Shivaram Prasad Singh
  • Arshdeep Singh
  • Intest Res.2020 Jul;ir.2019.09176. doi: 10.5217/ir.2019.09176.Epub 2020-07-13.

TPC1 欠損または遮断は、全身性アナフィラキシーおよび肥満細胞活性を増強する

TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity.
  • Elisabeth Arlt
  • Marco Fraticelli
  • Volodymyr Tsvilovskyy
  • Wiebke Nadolni
  • Andreas Breit
  • Thomas J O'Neill
  • Stefanie Resenberger
  • Gunther Wennemuth
  • Christian Wahl-Schott
  • Martin Biel
  • Christian Grimm
  • Marc Freichel
  • Thomas Gudermann
  • Norbert Klugbauer
  • Ingrid Boekhoff
  • Susanna Zierler
  • Proc. Natl. Acad. Sci. U.S.A..2020 Jul;201920122. doi: 10.1073/pnas.1920122117.Epub 2020-07-13.

職業的にヒ素、カドミウムおよび鉛に曝露された人のCNR1、MC4R、LEP、FTOおよびVDR遺伝子多型といくつかの基本的な毒物学的パラメータとの関係

The Relationship Between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead.
  • Tomasz Matys
  • Anna Szymańska-Chabowska
  • Katarzyna Bogunia-Kubik
  • Beata Smyk
  • Małgorzata Kamińska
  • Grzegorz Mazur
  • Rafał Poręba
  • Paweł Gać
  • J Clin Med.2020 Apr;9(4). E1040. doi: 10.3390/jcm9041040.Epub 2020-04-07.

Klippel-Trénaunay症候群患者における血栓塞栓性イベントの危険因子としての異常な静脈解剖学：コホート研究の中のケースコントロール研究

Aberrant venous anatomy as a risk factor for thromboembolic events in patients with Klippel-Trénaunay Syndrome: case-control study within a cohort study.
  • Lilly Geertruida Johanna Maria Zwerink
  • D Maroeska Wm Te Loo
  • Richard Praster
  • Bas H Verhoeven
  • Carine Jm van der Vleuten
  • J. Am. Acad. Dermatol..2020 Jul;S0190-9622(20)32183-6. doi: 10.1016/j.jaad.2020.07.019.Epub 2020-07-15.

ネオババイソフラボンは、RANKL シグナルを介した TRAF6 と c-Src のリクルート、NF-κB、MAPK、Akt パスウェイを阻害することにより、破骨細胞の発生を抑制します

Neobavaisoflavone inhibits osteoclastogenesis through blocking RANKL signalling-mediated TRAF6 and c-Src recruitment and NF-κB, MAPK and Akt pathways.
  • Huiwen Chen
  • Chao Fang
  • Xin Zhi
  • Shaojun Song
  • Yanqiu Gu
  • Xiaofei Chen
  • Jin Cui
  • Yan Hu
  • Weizong Weng
  • Qirong Zhou
  • Yajun Wang
  • Yao Wang
  • Hao Jiang
  • Xiaoqun Li
  • Liehu Cao
  • Xiao Chen
  • Jiacan Su
  • J. Cell. Mol. Med..2020 Jun;doi: 10.1111/jcmm.15543.Epub 2020-06-30.

成人の不眠症障害患者を対象とした lemborexant のプラセボと比較した長期的な有効性と忍容性：第 3 相無作為化臨床試験 SUNRISE 2 の結果

Long-term efficacy and tolerability of lemborexant compared with placebo in adults with insomnia disorder: results from the phase 3 randomized clinical trial SUNRISE 2.
  • Mikko Kärppä
  • Jane Yardley
  • Kate Pinner
  • Gleb Filippov
  • Gary Zammit
  • Margaret Moline
  • Carlos Perdomo
  • Yuichi Inoue
  • Kohei Ishikawa
  • Naoki Kubota
  • Sleep.2020 Jun;zsaa123. doi: 10.1093/sleep/zsaa123.Epub 2020-06-26.

不顕性CMVおよびEBVの脱落は、抑制的抗レトロウイルス療法中の末梢血中のHIV DNA分子多様性の増加と関連している

Subclinical CMV and EBV Shedding is associated with increasing HIV DNA Molecular Diversity in Peripheral Blood during Suppressive Antiretroviral Therapy.
  • Antoine Chaillon
  • Masato Nakazawa
  • Stephen A Rawlings
  • Genevieve Curtin
  • Gemma Caballero
  • Brianna Scott
  • Christy Anderson
  • Sara Gianella
  • J. Virol..2020 Jul;JVI.00927-20. doi: 10.1128/JVI.00927-20.Epub 2020-07-08.

地域に根ざした SARS-CoV-2 感染症の検出と遺伝的特性 - ニューヨーク市、2020 年 3 月

Detection and Genetic Characterization of Community-Based SARS-CoV-2 Infections - New York City, March 2020.
  • Dena Bushman
  • Karen A Alroy
  • Sharon K Greene
  • Page Keating
  • Amanda Wahnich
  • Don Weiss
  • Preeti Pathela
  • Christy Harrison
  • Jennifer Rakeman
  • Gayle Langley
  • Suxiang Tong
  • Ying Tao
  • Anna Uehara
  • Krista Queen
  • Clinton R Paden
  • Wendy Szymczak
  • Erika P Orner
  • Priya Nori
  • Phi A Lai
  • Jessica L Jacobson
  • Harjot K Singh
  • David P Calfee
  • Lars F Westblade
  • Ljiljana V Vasovic
  • Jacob H Rand
  • Dakai Liu
  • Vishnu Singh
  • Janice Burns
  • Nishant Prasad
  • Jessica Sell
  • MMWR Morb. Mortal. Wkly. Rep..2020 Jul;69(28):918-922. doi: 10.15585/mmwr.mm6928a5.Epub 2020-07-17.

バルーン封入型MWA（b-MWA）とバルーン封入型TACE（b-ACE）の併用療法。単発大型HCCに対する新しいシングルステップ併用療法に関するテクニカルノート

Balloon-Occluded MWA (b-MWA) Followed by Balloon-Occluded TACE (b-TACE): Technical Note on a New Combined Single-Step Therapy for Single Large HCC.
  • Roberto Iezzi
  • Alessandro Posa
  • Alessandro Tanzilli
  • Francesca Carchesio
  • Maurizio Pompili
  • Riccardo Manfredi
  • Cardiovasc Intervent Radiol.2020 Jul;10.1007/s00270-020-02583-6. doi: 10.1007/s00270-020-02583-6.Epub 2020-07-16.

脂肪量と肥満に関連する遺伝子多型，診断前の血漿アディポカイン値と大腸がんリスク．日本公衆衛生センターを拠点とするプロスペクティブ研究

Fat mass and obesity-associated gene polymorphisms, pre-diagnostic plasma adipokine levels and the risk of colorectal cancer: The Japan Public Health Center-based Prospective Study.
  • Taiki Yamaji
  • Motoki Iwasaki
  • Norie Sawada
  • Taichi Shimazu
  • Manami Inoue
  • Shoichiro Tsugane
  • PLoS ONE.2020;15(2):e0229005. PONE-D-19-17124. doi: 10.1371/journal.pone.0229005.Epub 2020-02-13.

顔面テーピングによるベル麻痺のリハビリテーションの成果向上のためのバイオフィードバック：無作為化症例対照研究の予備的結果

Facial taping as biofeedback to improve the outcomes of physical rehab in Bell's palsy: preliminary results of a randomized case-control study.
  • Arianna Di Stadio
  • Valeria Gambacorta
  • Massimo Ralli
  • Jenny Pagliari
  • Fabrizio Longari
  • Antonio Greco
  • Giampietro Ricci
  • Eur Arch Otorhinolaryngol.2020 Jul;10.1007/s00405-020-06193-3. doi: 10.1007/s00405-020-06193-3.Epub 2020-07-17.

硫化水素供与体GYY4137による耐性経路のアップレギュレーションと多発性硬化症におけるHS産生酵素の発現障害

Upregulation of Tolerogenic Pathways by the Hydrogen Sulfide Donor GYY4137 and Impaired Expression of HS-Producing Enzymes in Multiple Sclerosis.
  • Milica Lazarević
  • Giuseppe Battaglia
  • Bojan Jevtić
  • Neda Đedović
  • Valeria Bruno
  • Eugenio Cavalli
  • Đorđe Miljković
  • Ferdinando Nicoletti
  • Miljana Momčilović
  • Paolo Fagone
  • Antioxidants (Basel).2020 Jul;9(7). E608. doi: 10.3390/antiox9070608.Epub 2020-07-10.

男性のストレス性尿失禁の治療における固定式または調節式スリング：大規模コホート研究の結果

Fixed or adjustable sling in the treatment of male stress urinary incontinence: results from a large cohort study.
  • Tanja Hüsch
  • Alexander Kretschmer
  • Alice Obaje
  • Ruth Kirschner-Hermanns
  • Ralf Anding
  • Tobias Pottek
  • Achim Rose
  • Roberto Olianas
  • Alexander Friedl
  • Roland Homberg
  • Jesco Pfitzenmaier
  • Rudi Abdunnur
  • Fabian Queissert
  • Carsten M Naumann
  • Josef Schweiger
  • Carola Wotzka
  • Joanne Nyarangi-Dix
  • Torben Hofmann
  • Kurt Ulm
  • Wilhelm Hübner
  • Ricarda M Bauer
  • Axel Haferkamp
  • Transl Androl Urol.2020 Jun;9(3):1099-1107. tau-09-03-1099. doi: 10.21037/tau-19-852.

レプチン産生能は、Oikawa-Nagao Diabetes-PreoneマウスおよびDiabetes-Resistantマウスにおける食物摂取量および肥満誘発糖尿病感受性を決定した

Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa-Nagao Diabetes-Prone and Diabetes-Resistant mice.
  • Akira Asai
  • Mototsugu Nagao
  • Koji Hayakawa
  • Teruo Miyazawa
  • Hitoshi Sugihara
  • Shinichi Oikawa
  • Diabetologia.2020 Jun;10.1007/s00125-020-05191-8. doi: 10.1007/s00125-020-05191-8.Epub 2020-06-19.

集団飼育された子牛の超音波検査による肺病変、気道炎症、感染症と牛舎の室内空気質パラメータとの関連

Associations of barn air quality parameters with ultrasonographic lung lesions, airway inflammation and infection in group-housed calves.
  • Katharina van Leenen
  • Jonathan Jouret
  • Peter Demeyer
  • Laura Van Driessche
  • Lieze De Cremer
  • Christien Masmeijer
  • Filip Boyen
  • Piet Deprez
  • Bart Pardon
  • Prev. Vet. Med..2020 Jun;181:105056. S0167-5877(19)30887-6. doi: 10.1016/j.prevetmed.2020.105056.Epub 2020-06-09.

Pacbioの全長トランスクリプトームシークエンスを用いたナシキビの熱ストレスと干ばつストレスのトランスクリプトーム解析

Transcriptome analysis of heat stress and drought stress in pearl millet based on Pacbio full-length transcriptome sequencing.
  • Min Sun
  • Dejun Huang
  • Ailing Zhang
  • Imran Khan
  • Haidong Yan
  • Xiaoshan Wang
  • Xinquan Zhang
  • Jian Zhang
  • Linkai Huang
  • BMC Plant Biol..2020 Jul;20(1):323. 10.1186/s12870-020-02530-0. doi: 10.1186/s12870-020-02530-0.Epub 2020-07-08.

FeO/SiO/APTS上に担持されたCu(II)のシッフ塩基錯体の合成、キャラクタリゼーション、バイオメディカルへの応用、分子動力学シミュレーションと分子ドッキング

Synthesis, Characterization, Biomedical Application, Molecular Dynamic Simulation and Molecular Docking of Schiff Base Complex of Cu(II) Supported on FeO/SiO/APTS.
  • Rahime Eshaghi Malekshah
  • Bahareh Fahimirad
  • Ali Khaleghian
  • Int J Nanomedicine.2020;15:2583-2603. 231062. doi: 10.2147/IJN.S231062.Epub 2020-04-20.

慢性肺アスペルギルス症の診断における血清学的検査の精度．システマティックレビューとメタアナリシス

Accuracy of serological tests for diagnosis of chronic pulmonary aspergillosis: A systematic review and meta-analysis.
  • Cláudia Elizabeth Volpe Chaves
  • Sandra Maria do Valle Leone de Oliveira
  • James Venturini
  • Antonio Jose Grande
  • Tatiane Fernanda Sylvestre
  • Rinaldo Poncio Mendes
  • Anamaria Mello Miranda Paniago
  • PLoS ONE.2020;15(3):e0222738. PONE-D-19-24582. doi: 10.1371/journal.pone.0222738.Epub 2020-03-17.

小児急性リンパ芽球性白血病における中枢神経系病変の新しい液体生検マーカーとしてのマイクロRNA-181a

MicroRNA-181a as novel liquid biopsy marker of central nervous system involvement in pediatric acute lymphoblastic leukemia.
  • Bálint Egyed
  • Nóra Kutszegi
  • Judit C Sági
  • András Gézsi
  • Andrea Rzepiel
  • Tamás Visnovitz
  • Péter Lőrincz
  • Judit Müller
  • Marianna Zombori
  • Csaba Szalai
  • Dániel J Erdélyi
  • Gábor T Kovács
  • Ágnes F Semsei
  • J Transl Med.2020 Jun;18(1):250. 10.1186/s12967-020-02415-8. doi: 10.1186/s12967-020-02415-8.Epub 2020-06-22.

強直性GABA作動性阻害は、体性感覚視床および異所性感覚における神経損傷誘発性求心性リモデリングに必須である

Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations.
  • Yasuyuki Nagumo
  • Yoshifumi Ueta
  • Hisako Nakayama
  • Hironobu Osaki
  • Yuichi Takeuchi
  • Naofumi Uesaka
  • Masanobu Kano
  • Mariko Miyata
  • Cell Rep.2020 Jun;31(12):107797. S2211-1247(20)30778-6. doi: 10.1016/j.celrep.2020.107797.

規制をサポートするためのナノ材料試験のための欧州共通のアプローチの使用：チタンと二酸化ケイ素の代表的なナノ材料のケーススタディ

Use of a common European approach for nanomaterials' testing to support regulation: a case study on titanium and silicon dioxide representative nanomaterials.
  • Andrea Zijno
  • Delia Cavallo
  • Gabriella Di Felice
  • Jessica Ponti
  • Bianca Barletta
  • Cinzia Butteroni
  • Silvia Corinti
  • Barbara De Berardis
  • Jessica Palamides
  • Cinzia L Ursini
  • Anna M Fresegna
  • Aureliano Ciervo
  • Raffele Maiello
  • Flavia Barone
  • J Appl Toxicol.2020 Jun;doi: 10.1002/jat.4002.Epub 2020-06-30.

健康なボランティアから誘導された喀痰から得られた肺胞マクロファージに対するBCGワクチン接種の効果

The effect of BCG vaccination on alveolar macrophages obtained from induced sputum from healthy volunteers.
  • Valerie A C M Koeken
  • Eva S van der Pasch
  • Guus P Leijte
  • Vera P Mourits
  • L Charlotte J de Bree
  • Simone J C F M Moorlag
  • Isadore Budnick
  • Nina Idh
  • Maria Lerm
  • Matthijs Kox
  • Arjan van Laarhoven
  • Mihai G Netea
  • Reinout van Crevel
  • Cytokine.2020 Jun;133:155135. S1043-4666(20)30151-4. doi: 10.1016/j.cyto.2020.155135.Epub 2020-06-10.

思春期前のモルモットの学習と記憶保持の赤字は、前もって有機リン系殺虫剤マラチオンの低レベルにさらされた

Learning and memory retention deficits in prepubertal guinea pigs prenatally exposed to low levels of the organophosphorus insecticide malathion.
  • Eric W Lumsden
  • Lillian McCowan
  • Joseph D Pescrille
  • William P Fawcett
  • Hegang Chen
  • Edson X Albuquerque
  • Jacek Mamczarz
  • Edna F R Pereira
  • Neurotoxicol Teratol.2020 Jul;:106914. S0892-0362(20)30028-3. doi: 10.1016/j.ntt.2020.106914.Epub 2020-07-08.

極地衣類に関連する Hymenobacter sp.PAMC 26554 と Hymenobacter sp.PAMC 26628 の比較ゲノム研究により、生息地に応じた多糖分解能の存在が明らかになった

Comparative Genomic Study of Polar Lichen-Associated Hymenobacter sp. PAMC 26554 and Hymenobacter sp. PAMC 26628 Reveals the Presence of Polysaccharide-Degrading Ability Based on Habitat.
  • Nisha Ghimire
  • So-Ra Han
  • Byeollee Kim
  • Hyun Park
  • Jun Hyuck Lee
  • Tae-Jin Oh
  • Curr. Microbiol..2020 Jul;10.1007/s00284-020-02120-1. doi: 10.1007/s00284-020-02120-1.Epub 2020-07-17.

アラブ首長国連邦の若いアラブ人集団における過体重および肥満感受性における遺伝的変異の意味合い

Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates.
  • Sarah El Hajj Chehadeh
  • Wael Osman
  • Suna Nazar
  • Laila Jerman
  • Ameera Alghafri
  • Ali Sajwani
  • Mohamed Alawlaqi
  • Mohamed AlObeidli
  • Herbert F Jelinek
  • Fatme AlAnouti
  • Kinda Khalaf
  • Habiba Alsafar
  • Gene.2020 May;739:144509. S0378-1119(20)30178-5. doi: 10.1016/j.gene.2020.144509.Epub 2020-02-25.

2型糖尿病を予防し、血糖値に対するメトホルミンの効果を高めるための腸内細菌叢の標的化。無作為化対照パイロット試験

Targeting the Intestinal Microbiota to Prevent Type 2 Diabetes and Enhance the Effect of Metformin on Glycaemia: A Randomised Controlled Pilot Study.
  • Talia Palacios
  • Luis Vitetta
  • Samantha Coulson
  • Claire D Madigan
  • Yan Y Lam
  • Rachel Manuel
  • David Briskey
  • Chelsea Hendy
  • Ji-Nu Kim
  • Thomas Ishoey
  • Maria J Soto-Giron
  • Eric M Schott
  • Gerardo Toledo
  • Ian D Caterson
  • Nutrients.2020 Jul;12(7). E2041. doi: 10.3390/nu12072041.Epub 2020-07-09.

miR-378aは骨格筋の血管新生に影響を与える

miR-378a influences vascularization in skeletal muscles.
  • Bart Krist
  • Paulina Podkalicka
  • Olga Mucha
  • Mateusz Mendel
  • Aleksandra Sępioł
  • Olga Martyna Rusiecka
  • Ewelina Józefczuk
  • Karolina Bukowska-Strakova
  • Anna Grochot-Przęczek
  • Mateusz Tomczyk
  • Damian Klóska
  • Mauro Giacca
  • Paweł Maga
  • Rafał Niżankowski
  • Alicja Józkowicz
  • Agnieszka Łoboda
  • Józef Dulak
  • Urszula Florczyk-Soluch
  • Cardiovasc. Res..2020 Jun;116(7):1386-1397. 5555293. doi: 10.1093/cvr/cvz236.

炎症性腸疾患の診断前の消化器症状の有病率と持続期間、およびタイムリーな専門家によるレビューの予測因子：集団ベースの研究

Prevalence and duration of gastrointestinal symptoms before diagnosis of Inflammatory Bowel Disease and predictors of timely specialist review: a population-based study.
  • J Blackwell
  • S Saxena
  • N Jayasooriya
  • A Bottle
  • I Petersen
  • M Hotopf
  • C Alexakis
  • R C Pollok
  • J Crohns Colitis.2020 Jul;jjaa146. doi: 10.1093/ecco-jcc/jjaa146.Epub 2020-07-15.

ケモカインCCL19の血漿中濃度が高いと、SARS-CoV-2急性呼吸窮迫症候群（ARDS）の予後が悪くなります

Higher plasma levels of Chemokine CCL19 are associated with poor SARS-CoV-2 acute respiratory distress syndrome (ARDS) outcomes.
  • Joseph Balnis
  • Alejandro P Adam
  • Amit Chopra
  • Hau C Chieng
  • Paul J Feustel
  • Katherine A Overmyer
  • Evgenia Shishkova
  • Joshua C Coon
  • Harold A Singer
  • Marc A Judson
  • Ariel Jaitovich
  • medRxiv.2020 May;2020.05.21.20051300. doi: 10.1101/2020.05.21.20051300.Epub 2020-05-22.

TGF-β1によるブラジキニンB1受容体のアップレギュレーションがラット心筋線維芽細胞の抗線維化活性を促進することを明らかにした

TGF-β1 induced up-regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts.
  • Mabel Catalán
  • Pablo Aránguiz
  • Pía Boza
  • Ivonne Olmedo
  • Claudio Humeres
  • Raúl Vivar
  • Renatto Anfossi
  • Pedro Ayala
  • Claudio Espinoza
  • Sergio Lavandero
  • Guillermo Díaz-Araya
  • Mol. Biol. Rep..2019 Oct;46(5):5197-5207. 10.1007/s11033-019-04977-3. doi: 10.1007/s11033-019-04977-3.Epub 2019-07-15.

Activity and MObility UsiNg Technology (AMOUNT) リハビリテーション試験 - 入院後の段階でのデバイス使用と理学療法サポートの説明

Activity and MObility UsiNg Technology (AMOUNT) rehabilitation trial - description of device use and physiotherapy support in the post-hospital phase.
  • Leanne Hassett
  • Maayken van den Berg
  • Heather Weber
  • Sakina Chagpar
  • Siobhan Wong
  • Ashley Rabie
  • Annie McCluskey
  • Richard I Lindley
  • Maria Crotty
  • Catherine Sherrington
  • Disabil Rehabil.2020 Jul;:1-7. doi: 10.1080/09638288.2020.1790679.Epub 2020-07-14.

ポリポロイディによって生産された綿の複製遺伝子は、遺伝子ツリーのトポロジーを圧倒的に揺さぶる、著しく上昇した不均衡な進化率を示している

Cotton Duplicated Genes Produced by Polyploidy Show Significantly Elevated and Unbalanced Evolutionary Rates, Overwhelmingly Perturbing Gene Tree Topology.
  • Fanbo Meng
  • Yuxin Pan
  • Jinpeng Wang
  • Jigao Yu
  • Chao Liu
  • Zhikang Zhang
  • Chendan Wei
  • He Guo
  • Xiyin Wang
  • Front Genet.2020;11:239. doi: 10.3389/fgene.2020.00239.Epub 2020-04-23.

活性化マクロファージは、COVID-19間質性肺炎の浸潤における主な炎症細胞である。F-フルオロコリンPET/CTを用いて、彼らの代謝活性を示すことができ、したがって炎症負荷のグレードを示すことは可能でしょうか？

Activated macrophages are the main inflammatory cell in COVID-19 interstitial pneumonia infiltrates. Is it possible to show their metabolic activity and thus the grade of inflammatory burden with F-Fluorocholine PET/CT?
  • G Savelli
  • M Bonacina
  • A Rizzo
  • A Zaniboni
  • Med. Hypotheses.2020 May;144:109885. S0306-9877(20)31123-3. doi: 10.1016/j.mehy.2020.109885.Epub 2020-05-27.

非刺激性アゴニストによる一過性受容体電位バニロイド1の脱感作と、ブラジキニンによるその再感作

The desensitization of the transient receptor potential vanilloid 1 by nonpungent agonists and its resensitization by bradykinin.
  • Mohammad Alsalem
  • Sara A Aldossary
  • Mansour Haddad
  • Ahmad Altarifi
  • Heba Kalbouneh
  • Belal Azab
  • Ayman G Mustafa
  • Sahar M Jaffal
  • Khalid El-Salem
  • Neuroreport.2020 Aug;31(11):781-786. 00001756-202008010-00003. doi: 10.1097/WNR.0000000000001485.

合成DNAをコードしたモノクローナル抗呼吸器性合胞体ウイルスscFv-Fc融合タンパク質を用いた積極的な免疫予防は、感染に対する保護と耐久性のある活性をもたらす

Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity.
  • Katherine Schultheis
  • Holly M Pugh
  • Janet Oh
  • Jacklyn Nguyen
  • Bryan Yung
  • Charles Reed
  • Neil Cooch
  • Jing Chen
  • Jian Yan
  • Kar Muthumani
  • Laurent M Humeau
  • David B Weiner
  • Kate E Broderick
  • Trevor R F Smith
  • Hum Vaccin Immunother.2020 Jun;:1-11. doi: 10.1080/21645515.2020.1748979.Epub 2020-06-16.

スラブ諸国におけるc.256_257delAA創始者変異を含む欠乏症患者82人の臨床と遺伝的スペクトル

The Clinical and Genetic Spectrum of 82 Patients With Deficiency Including a c.256_257delAA Founder Variant in Slavic Countries.
  • Svetlana O Sharapova
  • Małgorzata Skomska-Pawliszak
  • Yulia A Rodina
  • Beata Wolska-Kuśnierz
  • Nel Dabrowska-Leonik
  • Bozena Mikołuć
  • Olga E Pashchenko
  • Srdjan Pasic
  • Tomáš Freiberger
  • Tomáš Milota
  • Renata Formánková
  • Anna Szaflarska
  • Maciej Siedlar
  • Tadej Avčin
  • Gašper Markelj
  • Peter Ciznar
  • Krzysztof Kalwak
  • Sylwia Kołtan
  • Teresa Jackowska
  • Katarzyna Drabko
  • Alenka Gagro
  • Małgorzata Pac
  • Elissaveta Naumova
  • Snezhina Kandilarova
  • Katarzyna Babol-Pokora
  • Dzmitry S Varabyou
  • Barbara H Barendregt
  • Elena V Raykina
  • Tatiana V Varlamova
  • Anna V Pavlova
  • Hana Grombirikova
  • Maruša Debeljak
  • Irina V Mersiyanova
  • Anastasiia V Bondarenko
  • Liudmyla I Chernyshova
  • Larysa V Kostyuchenko
  • Marina N Guseva
  • Jelena Rascon
  • Audrone Muleviciene
  • Egle Preiksaitiene
  • Christoph B Geier
  • Alexander Leiss-Piller
  • Yasuhiro Yamazaki
  • Tomoki Kawai
  • Jolan E Walter
  • Irina V Kondratenko
  • Anna Šedivá
  • Mirjam van der Burg
  • Natalia B Kuzmenko
  • Luigi D Notarangelo
  • Ewa Bernatowska
  • Olga V Aleinikova
  • Front Immunol.2020;11:900. doi: 10.3389/fimmu.2020.00900.Epub 2020-06-10.

骨端の電気鍼治療は、モルヒネ耐性を持つ骨癌性疼痛ラットにおいて、ロカス・ケアルーレ座におけるGRK5、β-arrestin 2およびPKCαタンパク質の発現を調節することにより、痛みを和らげます

[Bone-edge electroacupuncture relieves pain by regulating expression of GRK5, β-arrestin 2 and PKCα proteins in locus coeruleus in bone cancer pain rats with morphine tolerance].
  • Jun Ying Du
  • Feng Chen
  • Bin Jiang
  • Tao Fang Fu
  • Jian Qiao Fang
  • Yi Liang
  • Zhen Ci Yan Jiu.2020 Feb;45(2):87-92. doi: 10.13702/j.1000-0607.1900036.

テトラヒドロキノリン誘導体のワンポット多成分合成と抗酸化剤、α-アミラーゼ酵素阻害剤、抗癌剤、抗炎症剤としての生物学的評価

One-Pot Multicomponent Synthesis and Bioevaluation of Tetrahydroquinoline Derivatives as Potential Antioxidants, α-Amylase Enzyme Inhibitors, Anti-Cancerous and Anti-Inflammatory Agents.
  • Samra Farooq
  • Aqsa Mazhar
  • Areej Ghouri
  • Ihsan-Ul-Haq
  • Naseem Ullah
  • Molecules.2020 Jun;25(11). E2710. doi: 10.3390/molecules25112710.Epub 2020-06-11.

ブルキナファソの保健地区における妊婦の重症マラリア感染とその転帰。2013年から2018年までの日常的に収集されたデータに階層的ベイズ時空モデルを適用した

Severe-malaria infection and its outcomes among pregnant women in Burkina Faso health-districts: Hierarchical Bayesian space-time models applied to routinely-collected data from 2013 to 2018.
  • Toussaint Rouamba
  • Sekou Samadoulougou
  • Halidou Tinto
  • Victor A Alegana
  • Fati Kirakoya-Samadoulougou
  • Spat Spatiotemporal Epidemiol.2020 Jun;33:100333. S1877-5845(20)30011-3. doi: 10.1016/j.sste.2020.100333.Epub 2020-02-15.

ブラジルの健康なヒトボランティアを対象とした2つのゾルピデムヘミタル酸塩製剤のタンデム質量分析と高速液体クロマトグラフィーを用いた比較バイオアベイラビリティー

Comparative bioavailability of two zolpidem hemitartrate formulations in healthy human Brazilian volunteers using high-performance liquid chromatography coupled to tandem mass spectrometry.
  • Gustavo D Mendes
  • Thais da Silva Pereira
  • Júlio César Rodrigues
  • Elaine Marcílio Santos
  • Mariani Rafaela Souza
  • Rodrigo Alvaro Brandão Lopes-Martins
  • Natalícia de Jesus Antunes
  • Ronilson Agnaldo Moreno
  • Gilberto De Nucci
  • Biomed. Chromatogr..2020 Apr;34(4):e4731. doi: 10.1002/bmc.4731.Epub 2020-01-23.

3つの異なるソースに由来するC57BL/6Nマウスにおける1-メチル-4-フェニル-1,2,3,6-テトラヒドロピリジンに対する用量依存性の神経毒性反応の比較分析

Comparative analysis of dose-dependent neurotoxic response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 N mice derived from three different sources.
  • Dong-Joo Hwang
  • Ki-Chun Kwon
  • Hyun-Keun Song
  • Kil-Soo Kim
  • Young-Suk Jung
  • Dae-Youn Hwang
  • Joon-Yong Cho
  • Lab Anim Res.2019;35:10. 12. doi: 10.1186/s42826-019-0012-2.Epub 2019-07-25.

膵液採取に対するエンドソノグラフィーガイド下の経膜ドレナージ：ステントの種類による比較結果

Endosonography-guided transmural drainage of pancreatic fluid collections: comparative outcomes by stent type.
  • Ahmed Kayal
  • Niloofar Taghizadeh
  • Takuya Ishikawa
  • Emmanuel Gonzalez-Moreno
  • Sydney Bass
  • Martin J Cole
  • Steven J Heitman
  • Rachid Mohamed
  • Christian Turbide
  • Yen-I Chen
  • Nauzer Forbes
  • Surg Endosc.2020 Jun;10.1007/s00464-020-07699-x. doi: 10.1007/s00464-020-07699-x.Epub 2020-06-15.

Secoeudesma sesquiterpenes lactone Aは、カルバペネム耐性肺炎球菌の重症感染症において炎症を緩和し、アジュバント保護を提供する

Secoeudesma sesquiterpenes lactone A alleviates inflammation and offers adjuvant protection in severe infection of carbapenem-resistant Klebsiella pneumoniae.
  • Xinru Jiang
  • Yijian Chen
  • Dan Liu
  • Ting Shi
  • Xiaodong Cheng
  • Weigang He
  • Yinhong Li
  • Bernhard Ryffel
  • Song Guo Zheng
  • Yuejuan Zheng
  • J Ethnopharmacol.2020 Apr;252:112605. S0378-8741(19)34638-0. doi: 10.1016/j.jep.2020.112605.Epub 2020-01-22.

単一トリプトファン型光活性オレンジカロテノイド蛋白質におけるカロテノイド-トリプトファン水素結合ダイナミクスの解明

Probing of carotenoid-tryptophan hydrogen bonding dynamics in the single-tryptophan photoactive Orange Carotenoid Protein.
  • Eugene G Maksimov
  • Elena A Protasova
  • Georgy V Tsoraev
  • Igor A Yaroshevich
  • Anton I Maydykovskiy
  • Evgeny A Shirshin
  • Timofey S Gostev
  • Alexander Jelzow
  • Marcus Moldenhauer
  • Yury B Slonimskiy
  • Nikolai N Sluchanko
  • Thomas Friedrich
  • Sci Rep.2020 Jul;10(1):11729. 10.1038/s41598-020-68463-8. doi: 10.1038/s41598-020-68463-8.Epub 2020-07-16.

滋賀トキシンはヒト糸球体微小血管内皮におけるSyndecan-4および接着分子ICAM-1の発現を選択的にアップレギュレートする

Shiga Toxin Selectively Upregulates Expression of Syndecan-4 and Adhesion Molecule ICAM-1 in Human Glomerular Microvascular Endothelium.
  • Elena B Volokhina
  • Wouter J C Feitz
  • Lonneke M Elders
  • Thea J A M van der Velden
  • Nicole C A J van de Kar
  • Lambertus P W J van den Heuvel
  • Toxins (Basel).2020 Jul;12(7). E435. doi: 10.3390/toxins12070435.Epub 2020-07-03.

アロステリックおよびATP競合的なmTORの阻害剤は、Tsc2マウスの腎臓における腫瘍の進行と上皮-間葉系転移を効果的に抑制する

Allosteric and ATP-Competitive Inhibitors of mTOR Effectively Suppress Tumor Progression-Associated Epithelial-Mesenchymal Transition in the Kidneys of Tsc2 Mice.
  • Ashley T Jones
  • Jian Yang
  • Kalin Narov
  • Elizabeth P Henske
  • Julian R Sampson
  • Ming Hong Shen
  • Neoplasia.2019 08;21(8):731-739. S1476-5586(19)30148-4. doi: 10.1016/j.neo.2019.05.003.Epub 2019-06-14.

ジャスモン酸メチルは、モノアミン神経伝達、抗酸化防御システム、Nrf2発現の調節を介して、慢性的なストレス誘発性の記憶機能障害を逆転させる

Methyl jasmonate reverses chronic stress-induced memory dysfunctions through modulation of monoaminergic neurotransmission, antioxidant defense system, and Nrf2 expressions.
  • Oritoke M Aluko
  • Solomon Umukoro
  • Naunyn Schmiedebergs Arch. Pharmacol..2020 Jul;10.1007/s00210-020-01939-6. doi: 10.1007/s00210-020-01939-6.Epub 2020-07-14.

ポリエチレンマイクロプラスチックに曝露されたスクラクチンサンゴの生理的ストレス応答（英文

Physiological stress response of the scleractinian coral Stylophora pistillata exposed to polyethylene microplastics.
  • Chantal M Lanctôt
  • Vanessa N Bednarz
  • Steven Melvin
  • Hugo Jacob
  • François Oberhaensli
  • Peter W Swarzenski
  • Christine Ferrier-Pagès
  • Anthony R Carroll
  • Marc Metian
  • Environ. Pollut..2020 Aug;263(Pt A):114559. S0269-7491(19)36710-7. doi: 10.1016/j.envpol.2020.114559.Epub 2020-04-12.

SCREENED.甲状腺機能の多段階モデルを用いて、生物学的に性別に特化した方法で内分泌かく乱物質をスクリーニングする

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner.
  • Lorenzo Moroni
  • Fulvio Barbaro
  • Florian Caiment
  • Orla Coleman
  • Sabine Costagliola
  • Giusy Di Conza
  • Lisa Elviri
  • Stefan Giselbrecht
  • Christian Krause
  • Carlos Mota
  • Marta Nazzari
  • Stephen R Pennington
  • Annette Ringwald
  • Monica Sandri
  • Simon Thomas
  • James Waddington
  • Roberto Toni
  • Int J Mol Sci.2020 May;21(10). E3648. doi: 10.3390/ijms21103648.Epub 2020-05-21.

セリアック病の病原性ペプチドに対する加水分解活性を向上させたスフィンゴモナス・カプシュラータ由来のプロリルエンドペプチダーゼを合理的に設計した

Rationally engineered prolyl endopeptidases from Sphingomonas capsulata with improved hydrolytic activity towards pathogenic peptides of celiac diseases.
  • Bin Xiao
  • Chun Zhang
  • Xiaotong Song
  • Miao Wu
  • Jianping Mao
  • Rong Yu
  • Yongxiang Zheng
  • Eur J Med Chem.2020 Jul;202:112499. S0223-5234(20)30471-2. doi: 10.1016/j.ejmech.2020.112499.Epub 2020-07-06.

放射光フーリエ変換赤外顕微分光法を用いた慢性アレルギー性気道疾患のマウスモデルにおける実験化合物の分子機構の解明

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy.
  • Nadia Mazarakis
  • Jitraporn Vongsvivut
  • Keith R Bambery
  • Katherine Ververis
  • Mark J Tobin
  • Simon G Royce
  • Chrishan S Samuel
  • Kenneth J Snibson
  • Paul V Licciardi
  • Tom C Karagiannis
  • Sci Rep.2020 Jul;10(1):11713. 10.1038/s41598-020-68671-2. doi: 10.1038/s41598-020-68671-2.Epub 2020-07-16.

5年間のレトロスペクティブ研究により、カーボベルデでは黄色ブドウ球菌と大腸菌の両方で抗菌薬耐性が増加していることが示された

A five-year retrospective study shows increasing rates of antimicrobial drug resistance in Cabo Verde for both Staphylococcus aureus and Escherichia coli.
  • Tamar Monteiro
  • Magdalena Wysocka
  • Elena Tellez
  • Ofelia Monteiro
  • Luzia Spencer
  • Elisa Veiga
  • Sandra Monteiro
  • Carine de Pina
  • Deisy Gonçalves
  • Sandrine de Pina
  • Antonio Ludgero-Correia
  • Joao Moreno
  • Teresa Conceição
  • Marta Aires De Sousa
  • Herminia de Lencastre
  • Laura J Gray
  • Manish Pareek
  • David R Jenkins
  • Sandra Beleza
  • Marco R Oggioni
  • Isabel Inês Araujo
  • J Glob Antimicrob Resist.2020 Apr;22:483-487. S2213-7165(20)30094-1. doi: 10.1016/j.jgar.2020.04.002.Epub 2020-04-27.

石英光音響分光法を用いて検出された混合物中のガス濃度を取得するためのツールとしての部分最小二乗回帰

Partial least squares regression as a tool to retrieve gas concentrations in mixtures detected by using quartz-enhanced photoacoustic spectroscopy.
  • Andrea Zifarelli
  • Marilena Giglio
  • Giansergio Menduni
  • Angelo Sampaolo
  • Pietro Patimisco
  • Vittorio M N Passaro
  • Hongpeng Wu
  • Lei Dong
  • Vincenzo Spagnolo
  • Anal. Chem..2020 Jul;doi: 10.1021/acs.analchem.0c00075.Epub 2020-07-17.

深層畳み込みニューラルネットワークベースのソフトウェアは、胸部X線写真上の悪性肺結節の放射線技師による検出を改善する

Deep Convolutional Neural Network-based Software Improves Radiologist Detection of Malignant Lung Nodules on Chest Radiographs.
  • Yongsik Sim
  • Myung Jin Chung
  • Elmar Kotter
  • Sehyo Yune
  • Myeongchan Kim
  • Synho Do
  • Kyunghwa Han
  • Hanmyoung Kim
  • Seungwook Yang
  • Dong-Jae Lee
  • Byoung Wook Choi
  • Radiology.2020 01;294(1):199-209. doi: 10.1148/radiol.2019182465.Epub 2019-11-12.

miR319を標的としたGhTCP4は、綿繊維の細胞伸長から細胞壁の肥厚への移行を促進する

The miR319-Targeted GhTCP4 Promotes the Transition from Cell Elongation to Wall Thickening in Cotton Fiber.
  • Jun-Feng Cao
  • Bo Zhao
  • Chao-Chen Huang
  • Zhi-Wen Chen
  • Ting Zhao
  • Hong-Ru Liu
  • Guan-Jing Hu
  • Xiao-Xia Shangguan
  • Chun-Min Shan
  • Ling-Jian Wang
  • Tian-Zhen Zhang
  • Jonathan F Wendel
  • Xue-Ying Guan
  • Xiao-Ya Chen
  • Mol Plant.2020 Jul;13(7):1063-1077. S1674-2052(20)30141-6. doi: 10.1016/j.molp.2020.05.006.Epub 2020-05-16.

2cm未満の腎/尿管結石の治療を目的とした2つの低侵襲手技の直接/間接コストの比較分析

Comparative analysis of direct and indirect costs of two minimally invasive techniques for the treatment of renal/ureteral calculi smaller than 2 cm.
  • J Perez-Ardavin
  • L Lorenzo
  • V Caballer-Tarazona
  • A Budía-Alba
  • D Vivas-Consuelo
  • P Bahilo-Mateu
  • G Ordaz-Jurado
  • M Trassierra-Villa
  • J D López-Acón
  • F Boronat-Tormo
  • Actas Urol Esp.2020 Jun;S0210-4806(20)30080-2. doi: 10.1016/j.acuro.2020.03.008.Epub 2020-06-24.

切除不能または転移性の悪性末梢神経鞘腫瘍患者を対象としたパゾパニブの第Ⅱ相臨床試験

Phase II clinical trial of pazopanib for patients with unresectable or metastatic malignant peripheral nerve sheath tumors.
  • Yoshihiro Nishida
  • Hiroshi Urakawa
  • Robert Nakayama
  • Eisuke Kobayashi
  • Toshifumi Ozaki
  • Keisuke Ae
  • Yoshihiro Matsumoto
  • Hiroyuki Tsuchiya
  • Takahiro Goto
  • Hiroaki Hiraga
  • Norifumi Naka
  • Shunji Takahashi
  • Yuichi Ando
  • Masahiko Ando
  • Yachiyo Kuwatsuka
  • Shunsuke Hamada
  • Takafumi Ueda
  • Akira Kawai
  • Int. J. Cancer.2020 Jul;doi: 10.1002/ijc.33201.Epub 2020-07-07.

脂肪アシル鎖の長さとアシル化部位のアシルトランスフェラーゼによる選択が、細菌のRTX毒素の活性化に関与していることが明らかになった

Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins.
  • Adriana Osickova
  • Humaira Khaliq
  • Jiri Masin
  • David Jurnecka
  • Anna Sukova
  • Radovan Fiser
  • Jana Holubova
  • Ondrej Stanek
  • Peter Sebo
  • Radim Osicka
  • J. Biol. Chem..2020 Jul;295(28):9268-9280. RA120.014122. doi: 10.1074/jbc.RA120.014122.Epub 2020-05-27.

β細胞の成熟期と糖尿病の代謝可塑性を支えるmTORC1からAMPKへのスイッチング

mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes.
  • Rami Jaafar
  • Stella Tran
  • Ajit N Shah
  • Gao Sun
  • Martin Valdearcos
  • Piero Marchetti
  • Matilde Masini
  • Avital Swisa
  • Simone Giacometti
  • Ernesto Bernal-Mizrachi
  • Aleksey Matveyenko
  • Matthias Hebrok
  • Yuval Dor
  • Guy A Rutter
  • Suneil K Koliwad
  • Anil Bhushan
  • J. Clin. Invest..2019 07;129(10):4124-4137. 127021. doi: 10.1172/JCI127021.Epub 2019-07-02.

転移性非小細胞肺がん患者とその配偶者に対する支持的ケア戦略としてのマインドフルネスに基づく介入．3アームのパイロット無作為化対照試験の結果

A Mindfulness-Based Intervention as a Supportive Care Strategy for Patients with Metastatic Non-Small Cell Lung Cancer and their Spouses: Results of a 3-Arm Pilot Randomized Controlled Trial.
  • Kathrin Milbury
  • Yisheng Li
  • Sania Durrani
  • Zhongxing Liao
  • Anne S Tsao
  • Cindy Carmack
  • Lorenzo Cohen
  • Eduardo Bruera
  • Oncologist.2020 Jul;doi: 10.1634/theoncologist.2020-0125.Epub 2020-07-04.

生のココナッツコアーと綿、廃バガス、木材、竹の粉砕粉末をホットプレスして調製した植物繊維ベースのバイオポリマーの機械的、熱的、構造的特性に関するデータセット

Dataset on mechanical, thermal and structural characterization of plant fiber-based biopolymers prepared by hot-pressing raw coconut coir, and milled powders of cotton, waste bagasse, wood, and bamboo.
  • Mohammed Abdullah Hamad Alharbi
  • Shinji Hirai
  • Hoang Anh Tuan
  • Shota Akioka
  • Wataru Shoji
  • Data Brief.2020 Jun;30:105510. S2352-3409(20)30404-2. doi: 10.1016/j.dib.2020.105510.Epub 2020-04-21.

ホルモン感受性前立腺癌のリュープロレリン治療を受けた被験者の集団疾患進行モデルを開発するために、医療請求書データベースを使用しています

Using medical claims database to develop a population disease progression model for leuprorelin-treated subjects with hormone-sensitive prostate cancer.
  • Yixuan Zou
  • Fei Tang
  • Jeffery C Talbert
  • Chee M Ng
  • PLoS ONE.2020;15(3):e0230571. PONE-D-19-27455. doi: 10.1371/journal.pone.0230571.Epub 2020-03-24.

ケニアの女性性労働者のための携帯電話をベースとした性と生殖の健康のための介入。開発と質的研究

A Mobile Phone-Based Sexual and Reproductive Health Intervention for Female Sex Workers in Kenya: Development and Qualitative Study.
  • Frances H Ampt
  • Kelly L'Engle
  • Megan S C Lim
  • Kate F Plourde
  • Emily Mangone
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脱髄後の脂質誘導リソソーム損傷はリソソーム貯蔵障害のミクログリア保護機能を壊す

Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders.
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膀胱癌細胞におけるラパマイシン複合体2の哺乳類標的によるカベオリン-1のリン酸化とカベオリン形成の動的制御

Dynamic Regulation of Caveolin-1 Phosphorylation and Caveolae Formation by Mammalian Target of Rapamycin Complex 2 in Bladder Cancer Cells.
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内腔乳癌細胞におけるMKL1の核内蓄積はERαのゲノム活性を低下させ、内分泌抵抗性と関連しています

Nuclear accumulation of MKL1 in luminal breast cancer cells impairs genomic activity of ERα and is associated with endocrine resistance.
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Netrin-1はWntとMAPKシグナルのNeo1とUnc5bの共調節を介してナイーブな多能性を促進する

Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling.
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Pileostegia tomentella (ZLTE)の酢酸エチル抽出物は、活性酸素誘導性アポトーシスを介してH1299細胞に抗がん作用を発揮します

The ethyl acetate extraction of Pileostegia tomentella (ZLTE) exerts anti-cancer effects on H1299 cells via ROS-induced canonical apoptosis.
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パーソナライズされた分散型患者指導システムの評価

Assessment of a personalized and distributed patient guidance system.
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舌の診断における人工知能深層畳み込みニューラルネットワークを用いた歯牙痕のある不健康な舌の認識

Artificial intelligence in tongue diagnosis: Using deep convolutional neural network for recognizing unhealthy tongue with tooth-mark.
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