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日本語AIでPubMedを検索

歯科医師情報サイトTOP / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
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2020年07月 みんなが読んでいる論文

輸液ポンプ薬の安全性ライブラリログの12ヶ月間のレビューで、投薬および投与量の選択ミスのヒヤリハットの証拠、およびユーザーによる「良好な保存」の修正を確認した

A Twelve Month Review of Infusion Pump Medication Safety Library Logs for Evidence of Near-Miss Medication and Dose Selection Error and User Initiated 'Good Saves' Correction.
  • James Waterson
  • Rania Al-Jaber
  • Tarek Kassab
  • Abdulrazaq S Al-Jazairi
  • JMIR Hum Factors.2020 Jun;doi: 10.2196/20364.Epub 2020-06-25.

スーパーバスマティイネのCRISPR-Cas9媒介ゲノム編集を精密に行い、主要な感受性遺伝子を標的とした細菌病抵抗性の確立を目指す

Precise CRISPR-Cas9 Mediated Genome Editing in Super Basmati Rice for Resistance Against Bacterial Blight by Targeting the Major Susceptibility Gene.
  • Kashaf Zafar
  • Muhammad Zuhaib Khan
  • Imran Amin
  • Zahid Mukhtar
  • Sumera Yasmin
  • Muhammad Arif
  • Khansa Ejaz
  • Shahid Mansoor
  • Front Plant Sci.2020;11:575. doi: 10.3389/fpls.2020.00575.Epub 2020-06-12.

廃活性汚泥の嫌気性発酵をNaCl補助加水分解法で強化した。短鎖脂肪酸のバイオ生産性向上とNaCl再利用の実現可能性

Enhanced anaerobic fermentation of waste activated sludge by NaCl assistant hydrolysis strategy: Improved bio-production of short-chain fatty acids and feasibility of NaCl reuse.
  • Heliang Pang
  • Jie Xu
  • Junguo He
  • Xinlei Pan
  • Yingqun Ma
  • Le Li
  • Kunyi Li
  • Zhongsen Yan
  • Jun Nan
  • Bioresour. Technol..2020 Sep;312:123303. S0960-8524(20)30575-7. doi: 10.1016/j.biortech.2020.123303.Epub 2020-04-05.

干渉クロマトグラフィー：ウイルス精製のためのクロマトグラフィーの選択性と分離性能を最適化する新しいアプローチ

Interference chromatography: a novel approach to optimizing chromatographic selectivity and separation performance for virus purification.
  • Lisa A Santry
  • Renaud Jacquemart
  • Melissa Vandersluis
  • Mochao Zhao
  • Jake M Domm
  • Thomas M McAusland
  • Xiaojiao Shang
  • Pierre M Major
  • James G Stout
  • Sarah K Wootton
  • BMC Biotechnol..2020 Jun;20(1):32. 10.1186/s12896-020-00627-w. doi: 10.1186/s12896-020-00627-w.Epub 2020-06-17.

ヘム異化の過程で鉄がどのように処理されるか：ポリ（rC）結合タンパク質-2によって媒介される細胞内鉄輸送機構とヘムオキシゲナーゼの統合

How iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2.
  • Izumi Yanatori
  • Des R Richardson
  • Shinya Toyokuni
  • Fumio Kishi
  • Arch. Biochem. Biophys..2019 09;672:108071. S0003-9861(19)30282-6. doi: 10.1016/j.abb.2019.108071.Epub 2019-08-14.

サブトラクション多相CTアンギオグラフィ．頭蓋内動脈閉塞をより迅速に検出するための新しい技術

Subtraction multiphase CT angiography: A new technique for faster detection of intracranial arterial occlusions.
  • Danielle Byrne
  • John P Walsh
  • Gavin Sugrue
  • Emma Stanley
  • Michael Marnane
  • Cathal D Walsh
  • Peter Kelly
  • Sean Murphy
  • Eoin C Kavanagh
  • Peter J MacMahon
  • Eur Radiol.2018 Apr;28(4):1731-1738. 10.1007/s00330-017-5124-1. doi: 10.1007/s00330-017-5124-1.Epub 2017-11-13.

イヌの子宮動脈と精巣動脈の機能的特性を検証し、教育における実験動物組織の代替としての受容体媒介収縮の機能的特性を明らかにした

Validation of canine uterine and testicular arteries for the functional characterisation of receptor-mediated contraction as a replacement for laboratory animal tissues in teaching.
  • Louise Mulcahy
  • Elizabeth Tudor
  • Simon R Bailey
  • PLoS ONE.2020;15(5):e0230516. PONE-D-19-27660. doi: 10.1371/journal.pone.0230516.Epub 2020-05-26.

ショウジョウバエの脳内配線におけるシナプスパートナーの選択を制限するオートファジー依存性フィロポディアルキネティクス

Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring.
  • Ferdi Ridvan Kiral
  • Gerit Arne Linneweber
  • Thomas Mathejczyk
  • Svilen Veselinov Georgiev
  • Mathias F Wernet
  • Bassem A Hassan
  • Max von Kleist
  • Peter Robin Hiesinger
  • Nat Commun.2020 03;11(1):1325. 10.1038/s41467-020-14781-4. doi: 10.1038/s41467-020-14781-4.Epub 2020-03-12.

大うつ病性障害および認知機能障害を主観的に報告する患者において，デュロキセチンは抗うつ効果とは独立して認知機能を改善するか？

Does duloxetine improve cognitive function independently of its antidepressant effect in patients with major depressive disorder and subjective reports of cognitive dysfunction?
  • Tracy L Greer
  • Prabha Sunderajan
  • Bruce D Grannemann
  • Benji T Kurian
  • Madhukar H Trivedi
  • Depress Res Treat.2014;2014:627863. doi: 10.1155/2014/627863.Epub 2014-01-19.

ヒト多能性幹細胞をベースとしたモデルは、ウェルナー症候群とブルーム症候群の代謝性合併症の可能性のある原因として、副嚢前細胞の老化を示唆している

Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes.
  • Kim Jee Goh
  • Jian-Hua Chen
  • Nuno Rocha
  • Robert K Semple
  • Sci Rep.2020 May;10(1):7490. 10.1038/s41598-020-64136-8. doi: 10.1038/s41598-020-64136-8.Epub 2020-05-04.

アリルピペリジン-1-カルボジチオエートおよびベンジル1H-イミダゾール-1-カルボジチオエート：マイコバクテリウムとの戦いのための2つの潜在的な薬剤

Allyl piperidine -1-carbodiothioate and benzyl 1H-imidazole 1 carbodithioate: two potential agents to combat against mycobacteria.
  • Goutam Mukherjee
  • Koushik Mukherjee
  • Rituparna Das
  • Rahul Shubhra Mandal
  • Indranil Roy
  • Balaram Mukhopadhyay
  • Alok Kumar Sil
  • J. Appl. Microbiol..2020 Jul;doi: 10.1111/jam.14762.Epub 2020-07-02.

ヘキソキナーゼ(Hxk)とヒドロキシメチルグルタリル-CoA合成酵素(Erg13)の過剰発現による前駆体物質の合成促進により、工学的にβ-カロテンの生成を促進することを明らかにした

Promoting the Synthesis of Precursor Substances by Overexpressing Hexokinase (Hxk) and Hydroxymethylglutaryl-CoA Synthase (Erg13) to Elevate β-Carotene Production in Engineered .
  • Shan Qiang
  • Jing Wang
  • Xiao Chao Xiong
  • Yu Ling Qu
  • Liang Liu
  • Ching Yuan Hu
  • Yong Hong Meng
  • Front Microbiol.2020;11:1346. doi: 10.3389/fmicb.2020.01346.Epub 2020-06-19.

DEAD-BOX RNA ヘリカーゼをコードするシロイヌナズナ SMN2/HEN2 は、抵抗性遺伝子 SMN1/RPS6 の適切な発現を支配し、mekk1 と mpk4 変異体の矮小化、自己免疫性表現型に関与している

Arabidopsis SMN2/HEN2, Encoding DEAD-box RNA Helicase, Governs Proper Expression of the Resistance Gene SMN1/RPS6 and Is Involved in Dwarf, Autoimmune Phenotypes of mekk1 and mpk4 Mutants.
  • Momoko Takagi
  • Naoki Iwamoto
  • Yuta Kubo
  • Takayuki Morimoto
  • Hiroki Takagi
  • Fuminori Takahashi
  • Takumi Nishiuchi
  • Keisuke Tanaka
  • Teruaki Taji
  • Hironori Kaminaka
  • Kazuo Shinozaki
  • Kazuya Akimitsu
  • Ryohei Terauchi
  • Ken Shirasu
  • Kazuya Ichimura
  • Plant Cell Physiol..2020 May;pcaa071. doi: 10.1093/pcp/pcaa071.Epub 2020-05-28.

私は、コミュニティの悪者と非コミュニティとコミュニティのエンパワーメントの制御のための治療の第一の主人公になるために、私の保護者が来ています。エクアドルの限界集落における1980年から2018年までの経験と結果

[I promotori di salute come attori-protagonisti delle cure primarie nel controllo delle malattie comunicabili e non comunicabili e nell' empowerment delle comunità. Esperienza e risultati di lungo periodo in aree marginali in Ecuador dal 1980 al 2018.]
  • Cintia Caicedo
  • Mariella Anselmi
  • Rosanna Prandi
  • Monica Márquez
  • Br Dora Buonfrate
  • Federico Gobbi
  • Zeno Bisoffi
  • Gianni Tognoni
  • Assist Inferm Ric.2020 Jan-Mar;39(1):47-56. doi: 10.1702/3371.33476.

重症または重症のコロナウイルス病2019年成人を対象としたXuebijing注射剤（XBJ）の治療法とSARS-CoV-2に対するXBJの阻害効果についての検討を行いました

The study on the treatment of Xuebijing injection (XBJ) in adults with severe or critical Corona Virus Disease 2019 and the inhibitory effect of XBJ against SARS-CoV-2.
  • Qinhai Ma
  • Minshan Qiu
  • Hongxia Zhou
  • Jie Chen
  • Xue Yang
  • Zhenxuan Deng
  • Liping Chen
  • Jinchao Zhou
  • Yuping Liao
  • Qimin Chen
  • Qianwei Zheng
  • Lihua Cai
  • Lihan Shen
  • Zifeng Yang
  • Pharmacol. Res..2020 Jul;:105073. S1043-6618(20)31381-5. doi: 10.1016/j.phrs.2020.105073.Epub 2020-07-09.

羊にグリセロールをベースとした製剤を投与すると、eCG と同様の排卵率が得られますが、赤血球指標に影響を与える可能性があります

Administration of glycerol-based formulations in sheep results in similar ovulation rate to eCG but red blood cell indices may be affected.
  • Cristian Porcu
  • Francesca D Sotgiu
  • Valeria Pasciu
  • Maria Grazia Cappai
  • Alicia Barbero-Fernández
  • Antonio Gonzalez-Bulnes
  • Maria Dattena
  • Marilia Gallus
  • Giovanni Molle
  • Fiammetta Berlinguer
  • BMC Vet. Res..2020 Jun;16(1):207. 10.1186/s12917-020-02418-z. doi: 10.1186/s12917-020-02418-z.Epub 2020-06-22.

上部消化管内視鏡検査におけるレミマゾラムトシル酸塩。多施設、無作為化、非劣性、第III相試験

Remimazolam Tosilate in Upper Gastrointestinal Endoscopy: A Multicenter, Randomized, Non-inferiority, Phase III Trial.
  • Shao-Hui Chen
  • Tang-Mi Yuan
  • Jiao Zhang
  • Hua Bai
  • Ming Tian
  • Chu-Xiong Pan
  • Hong-Guang Bao
  • Xiao-Ju Jin
  • Fu-Hai Ji
  • Tai-Di Zhong
  • Qiang Wang
  • Jian-Rui Lv
  • Sheng Wang
  • Yu-Juan Li
  • Yong-Hao Yu
  • Ai-Lin Luo
  • Xiang-Kui Li
  • Su Min
  • Lin Li
  • Xiao-Hua Zou
  • Yu-Guang Huang
  • J. Gastroenterol. Hepatol..2020 Jul;doi: 10.1111/jgh.15188.Epub 2020-07-17.

リンケージマッピングとゲノムワイドアソシエーション研究に基づく芽期ジャポニカイネのアルカリ耐性のQTLマッピングと候補遺伝子解析

QTL Mapping and Candidate Gene Analysis for Alkali Tolerance in Japonica Rice at the bud Stage Based on Linkage Mapping and Genome-Wide Association Study.
  • Xianwei Li
  • Hongliang Zheng
  • Wenshen Wu
  • Hualong Liu
  • Jingguo Wang
  • Yan Jia
  • Jiaming Li
  • Luomiao Yang
  • Lei Lei
  • Detang Zou
  • Hongwei Zhao
  • Rice (N Y).2020 Jul;13(1):48. 10.1186/s12284-020-00412-5. doi: 10.1186/s12284-020-00412-5.Epub 2020-07-16.

アネキシンA5の過剰発現は、小児急性骨髄性白血病患者におけるゲムツズマブ・オゾガマイシンの治療選択の指針となる可能性がある

Overexpression of annexin A5 might guide the gemtuzumab ozogamicin treatment choice in patients with pediatric acute myeloid leukemia.
  • Nan Zhang
  • Ying Zhang
  • Ping Zhang
  • Shifeng Lou
  • Ying Chen
  • Huan Li
  • Hanqing Zeng
  • Yan Shen
  • Jianchuan Deng
  • Ther Adv Med Oncol.2020;12:1758835920927635. 10.1177_1758835920927635. doi: 10.1177/1758835920927635.Epub 2020-05-27.

夜間およびシフトワーカーの妥協した睡眠と概日リズムの乱れは、2019年のコロナウイルス病（COVID-19）に対して非常に脆弱になりますか？

Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
  • Flavia Rodrigues da Silva
  • Renato de Carvalho Guerreiro
  • Henrique de Araújo Andrade
  • Eduardo Stieler
  • Andressa Silva
  • Marco Túlio de Mello
  • Chronobiol. Int..2020 May;:1-11. doi: 10.1080/07420528.2020.1756841.Epub 2020-05-20.

腸管上皮細胞では、炎症性および分裂性シグナルがIL12Bとは独立してインターロイキン23サブユニットアルファ（IL23A）の分泌を駆動する

Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells.
  • Kee Siang Lim
  • Zachary Wei Ern Yong
  • Huajing Wang
  • Tuan Zea Tan
  • Ruby Yun-Ju Huang
  • Daisuke Yamamoto
  • Noriyuki Inaki
  • Masaharu Hazawa
  • Richard W Wong
  • Hiroko Oshima
  • Masanobu Oshima
  • Yoshiaki Ito
  • Dominic Chih-Cheng Voon
  • J. Biol. Chem..2020 May;295(19):6387-6400. RA120.012943. doi: 10.1074/jbc.RA120.012943.Epub 2020-03-24.

心血管安全性薬理試験の試験デザインとデータ解釈を中心とした業界調査

An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation.
  • Simon Authier
  • Matthew M Abernathy
  • Krystle Correll
  • Ray W Chui
  • Jill Dalton
  • C Michael Foley
  • Gregory S Friedrichs
  • John E Koerner
  • Mary-Jeanne Kallman
  • Malar Pannirselvam
  • William S Redfern
  • Vijay Urmaliya
  • Jean-Pierre Valentin
  • Todd Wisialowski
  • Tanja S Zabka
  • Michael K Pugsley
  • Int. J. Toxicol..2020 May;:1091581820921338. doi: 10.1177/1091581820921338.Epub 2020-05-14.

アンジオテンシノーゲンを標的としたRNA干渉治療薬は、げっ歯類モデルにおける胎児期前症候群の表現型を改善する

RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
  • Nadine Haase
  • Donald J Foster
  • Mark W Cunningham
  • Julia Bercher
  • Tuyen Nguyen
  • Svetlana Shulga-Morskaya
  • Stuart Milstein
  • Sarfraz Shaikh
  • Jeff Rollins
  • Michaela Golic
  • Florian Herse
  • Kristin Kräker
  • Ivo Bendix
  • Meray Serdar
  • Hanna Napieczynska
  • Arnd Heuser
  • Alexandra Gellhaus
  • Kristin Thiele
  • Gerd Wallukat
  • Dominik N Müller
  • Babbette LaMarca
  • Ralf Dechend
  • J. Clin. Invest..2020 Jun;130(6):2928-2942. 99417. doi: 10.1172/JCI99417.

元素配合飼料の使用に関連した低リン血症性骨疾患の長期追跡：配合飼料の変更またはリン酸塩補給後の骨疾患の持続的な修正

Long-Term Follow-up of Hypophosphatemic Bone Disease Associated With Elemental Formula Use: Sustained Correction of Bone Disease After Formula Change or Phosphate Supplementation.
  • Abigail S Eswarakumar
  • Nina S Ma
  • Leanne M Ward
  • Philippe Backeljauw
  • Halley Wasserman
  • David R Weber
  • Linda A DiMeglio
  • Erik A Imel
  • Julie Gagne
  • Declan Cody
  • Paul Zimakas
  • Lisa Swartz Topor
  • Sungeeta Agrawal
  • Andrew Calabria
  • Peter Tebben
  • Ruth S Faircloth
  • Rebecca Gordon
  • Linda Casey
  • Thomas O Carpenter
  • Clin Pediatr (Phila).2020 Jul;:9922820941097. doi: 10.1177/0009922820941097.Epub 2020-07-15.

オリプダーゼアルファによる肝スフィンゴミエリンのクリアランスは、酸スフィンゴミエリン酵素欠損症における脂質プロファイルの改善と関連しています

Clearance of Hepatic Sphingomyelin by Olipudase Alfa Is Associated With Improvement in Lipid Profiles in Acid Sphingomyelinase Deficiency.
  • Beth L Thurberg
  • Melissa P Wasserstein
  • Simon A Jones
  • Thomas D Schiano
  • Gerald F Cox
  • Ana Cristina Puga
  • Am. J. Surg. Pathol..2016 09;40(9):1232-42. doi: 10.1097/PAS.0000000000000659.

症候前の組織を解析することで、遅発性変性トリヌクレオチドリピート病の分子的・機序的起源を解明することができる

Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease.
  • Yongjun Chu
  • Jiaxin Hu
  • Hanquan Liang
  • Mohammed Kanchwala
  • Chao Xing
  • Walter Beebe
  • C Bradley Bowman
  • Xin Gong
  • David R Corey
  • V Vinod Mootha
  • Nucleic Acids Res..2020 Jul;48(12):6740-6758. 5848245. doi: 10.1093/nar/gkaa422.

多剤耐性黄色ブドウ球菌による糖尿病マウス創傷部感染症に対するファージカクテルAB-SA01の有効性

Efficacy of phage cocktail AB-SA01 therapy in diabetic mouse wound infections caused by multidrug-resistant Staphylococcus aureus.
  • Legesse Garedew Kifelew
  • Morgyn S Warner
  • Sandra Morales
  • Lewis Vaughan
  • Richard Woodman
  • Robert Fitridge
  • James G Mitchell
  • Peter Speck
  • BMC Microbiol..2020 Jul;20(1):204. 10.1186/s12866-020-01891-8. doi: 10.1186/s12866-020-01891-8.Epub 2020-07-09.

カロテノイドのラマンシグナルは、高線量ガンマ線照射後に乾燥した砂漠のシアノバクテリウムの細胞では、水和した細胞よりもよく保存されている

Carotenoid Raman Signatures Are Better Preserved in Dried Cells of the Desert Cyanobacterium than in Hydrated Counterparts after High-Dose Gamma Irradiation.
  • Mickael Baqué
  • Alessandro Napoli
  • Claudia Fagliarone
  • Ralf Moeller
  • Jean-Pierre de Vera
  • Daniela Billi
  • Life (Basel).2020 Jun;10(6). E83. doi: 10.3390/life10060083.Epub 2020-06-08.

スフィンゴシン-1-リン酸代謝の細胞・分子変化に着目したNPC1病における脳特異的な治療効果の解明

Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism.
  • Anne Gläser
  • Franziska Hammerl
  • Markus H Gräler
  • Sina M Coldewey
  • Christin Völkner
  • Moritz J Frech
  • Fan Yang
  • Jiankai Luo
  • Eric Tönnies
  • Oliver von Bohlen Und Halbach
  • Nicola Brandt
  • Diana Heimes
  • Anna-Maria Neßlauer
  • Georg Christoph Korenke
  • Marta Owczarek-Lipska
  • John Neidhardt
  • Arndt Rolfs
  • Andreas Wree
  • Martin Witt
  • Anja Ursula Bräuer
  • Int J Mol Sci.2020 Jun;21(12). E4502. doi: 10.3390/ijms21124502.Epub 2020-06-24.

線維芽細胞増殖因子1は、炎症と酸化ストレスの抑制を介して糖尿病誘発性脾臓巨大症を改善する

Fibroblast growth factor 1 ameliorates diabetes-induced splenomegaly via suppressing inflammation and oxidative stress.
  • Yanqing Wu
  • Gaili Jia
  • Beini Wang
  • Jun Xiong
  • Jingyu Xu
  • Peipei Zheng
  • Yuan Yuan
  • Yiyang Li
  • Ting Jiang
  • Abdullah Al Mamun
  • Ke Xu
  • Yaqian Liu
  • Hong Cao
  • Jian Xiao
  • Biochem. Biophys. Res. Commun..2020 Jul;528(2):249-255. S0006-291X(20)31073-1. doi: 10.1016/j.bbrc.2020.05.145.Epub 2020-05-29.

複数の毎日のインスリン注射（GOLD-3）を投与された1型糖尿病患者における夜間低血糖、日中低血糖、血糖変動、および低血糖の信頼性に対する持続的血糖モニタリングの効果の無作為化臨床試験

A Randomized Clinical Trial of the Effect of Continuous Glucose Monitoring on Nocturnal Hypoglycemia, Daytime Hypoglycemia, Glycemic Variability, and Hypoglycemia Confidence in Persons with Type 1 Diabetes Treated with Multiple Daily Insulin Injections (GOLD-3).
  • Arndís F Ólafsdóttir
  • William Polonsky
  • Jan Bolinder
  • Irl B Hirsch
  • Sofia Dahlqvist
  • Hans Wedel
  • Thomas Nyström
  • Magnus Wijkman
  • Erik Schwarcz
  • Jarl Hellman
  • Tim Heise
  • Marcus Lind
  • Diabetes Technol. Ther..2018 04;20(4):274-284. doi: 10.1089/dia.2017.0363.Epub 2018-04-02.

心臓における緩和ケア：イタリア心臓病学会/イタリア緩和ケア学会（SIC/SICP）のコンセンサス文書

[Palliative care in the cardiac setting: a consensus document of the Italian Society of Cardiology/Italian Society of Palliative Care (SIC/SICP)].
  • Raffaella Antonione
  • Gianfranco Sinagra
  • Matteo Moroni
  • Michele Correale
  • Dario Redaelli
  • Domenico Scrutinio
  • Eugenia Malinverni
  • Savina Nodari
  • Raffaele Calabrò
  • Italo Penco
  • Giuseppe Mercuro
  • G Ital Cardiol (Rome).2019 Jan;20(1):46-61. doi: 10.1714/3079.30720.

Covid-19.英国の第二波への備えについての迅速で前向きな見直しを求める-英国の全政党の指導者への公開書簡

Covid-19: Call for a rapid forward looking review of the UK's preparedness for a second wave-an open letter to the leaders of all UK political parties.
  • Victor Adebowale
  • Derek Alderson
  • Wendy Burn
  • Jeanette Dickson
  • Fiona Godlee
  • Andrew Goddard
  • Michael Griffin
  • Katherine Henderson
  • Richard Horton
  • Martin Marshall
  • Jo Martin
  • Edward Morris
  • Chaand Nagpaul
  • Maggie Rae
  • Anne Marie Rafferty
  • Jackie Taylor
  • BMJ.2020 06;369:m2514. doi: 10.1136/bmj.m2514.Epub 2020-06-23.

グルタチオンとBcl-2の標的化は、bcl-xl、bcl-2、およびmcl-1を過剰発現するヒトA375メラノーマ異種移植片の化学放射線療法による排除を促進する

Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1.
  • Salvador Mena
  • María L Rodriguez
  • Angel Ortega
  • Sonia Priego
  • Elena Obrador
  • Miguel Asensi
  • Ignacio Petschen
  • Miguel Cerdá
  • Bob D Brown
  • José M Estrela
  • J Transl Med.2012 Jan;10:8. 1479-5876-10-8. doi: 10.1186/1479-5876-10-8.Epub 2012-01-10.

ラベルフリー多光子イメージングにより、テクスチャ解析に基づく脳腫瘍の認識が可能となり、382名の腫瘍患者を対象とした研究が行われた

Label-free multiphoton imaging allows brain tumor recognition based on texture analysis-a study of 382 tumor patients.
  • Ortrud Uckermann
  • Roberta Galli
  • Georg Mark
  • Matthias Meinhardt
  • Edmund Koch
  • Gabriele Schackert
  • Gerald Steiner
  • Matthias Kirsch
  • Neurooncol Adv.2020 Jan-Dec;2(1):vdaa035. vdaa035. doi: 10.1093/noajnl/vdaa035.Epub 2020-03-12.

AFG3L2タンパク質分解ドメインの病原性バリアントは、ハプロイン不全とプロテオスタティックストレス駆動型OMA1活性化を介してSCA28を引き起こす

Pathogenic variants in the AFG3L2 proteolytic domain cause SCA28 through haploinsufficiency and proteostatic stress-driven OMA1 activation.
  • Susanna Tulli
  • Andrea Del Bondio
  • Valentina Baderna
  • Davide Mazza
  • Franca Codazzi
  • Tyler Mark Pierson
  • Alessandro Ambrosi
  • Dagmar Nolte
  • Cyril Goizet
  • Camilo Toro
  • Jonathan Baets
  • Tine Deconinck
  • Peter DeJonghe
  • Paola Mandich
  • Giorgio Casari
  • Francesca Maltecca
  • J. Med. Genet..2019 08;56(8):499-511. jmedgenet-2018-105766. doi: 10.1136/jmedgenet-2018-105766.Epub 2019-03-25.

非定型子宮内膜過形成と最終組織診での予期せぬ癌．子宮内膜のサンプリング方法とリスク因子に関する研究

Atypical Endometrial Hyperplasia and Unexpected Cancers at Final Histology: A Study on Endometrial Sampling Methods and Risk Factors.
  • Luca Giannella
  • Giovanni Delli Carpini
  • Francesco Sopracordevole
  • Maria Papiccio
  • Matteo Serri
  • Giorgio Giorda
  • Dimitrios Tsiroglou
  • Anna Del Fabro
  • Andrea Ciavattini
  • Diagnostics (Basel).2020 Jul;10(7). E474. doi: 10.3390/diagnostics10070474.Epub 2020-07-13.

多発性硬化症および下部尿路症状を有する患者における有意な排泄機能障害の存在をスクリーニングするための症状ベースの質問票の使用：パイロット研究

Use of a symptom-based questionnaire to screen for the presence of significant voiding dysfunction in patients with multiple sclerosis and lower urinary tract symptoms: a pilot study.
  • Vivien Li
  • Jalesh N Panicker
  • Collette Haslam
  • Jeremy Chataway
  • J. Neurol..2020 Jul;10.1007/s00415-020-10068-2. doi: 10.1007/s00415-020-10068-2.Epub 2020-07-16.

N95およびSN95マスクを紫外線殺菌照射（UVGI）で除染しても、マスクの有効性と安全性は損なわれない。システマティックレビュー

Decontaminating N95 and SN95 masks with Ultraviolet Germicidal Irradiation (UVGI) does not impair mask efficacy and safety: A Systematic Review.
  • O'Hearn Katie
  • Shira Gertsman
  • Margaret Sampson
  • Richard Webster
  • Anne Tsampalieros
  • Rhiannon Ng
  • Jess Gibson
  • Anna-Theresa Lobos
  • Nina Acharya
  • Anirudh Agarwal
  • Samantha Boggs
  • Graham Chamberlain
  • Emiliyan Staykov
  • Lindsey Sikora
  • James Dayre McNally
  • J. Hosp. Infect..2020 Jul;S0195-6701(20)30345-5. doi: 10.1016/j.jhin.2020.07.014.Epub 2020-07-17.

突然変異のホットスポットを同定することで、KCNQ2てんかん脳症の病態メカニズムが明らかになった

Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy.
  • Jiaren Zhang
  • Eung Chang Kim
  • Congcong Chen
  • Erik Procko
  • Shashank Pant
  • Kin Lam
  • Jaimin Patel
  • Rebecca Choi
  • Mary Hong
  • Dhruv Joshi
  • Eric Bolton
  • Emad Tajkhorshid
  • Hee Jung Chung
  • Sci Rep.2020 Mar;10(1):4756. 10.1038/s41598-020-61697-6. doi: 10.1038/s41598-020-61697-6.Epub 2020-03-16.

マイクロ波を利用したセルロース加水分解用二官能性磁性固体酸の合成とナノセルロースの創製

Microwave-assisted synthesis of bifunctional magnetic solid acid for hydrolyzing cellulose to prepare nanocellulose.
  • Yunfeng Zhao
  • Hanwu Lei
  • Yuhuan Liu
  • Roger Ruan
  • Moriko Qian
  • Erguang Huo
  • Qingfa Zhang
  • Zhiyang Huang
  • Xiaona Lin
  • Chenxi Wang
  • Wendy Mateo
  • Elmar M Villota
  • Sci. Total Environ..2020 Aug;731:138751. S0048-9697(20)32268-3. doi: 10.1016/j.scitotenv.2020.138751.Epub 2020-05-04.

Lu-PSMA-617 ラジオリガンド療法を受けた転移性去勢抵抗性前立腺癌患者の循環腫瘍細胞の分子解析

Molecular analysis of circulating tumor cells of metastatic castration-resistant Prostate Cancer Patients receiving Lu-PSMA-617 Radioligand Therapy.
  • Katharina Kessel
  • Robert Seifert
  • Matthias Weckesser
  • Wolfgang Roll
  • Verena Humberg
  • Katrin Schlack
  • Martin Bögemann
  • Christof Bernemann
  • Kambiz Rahbar
  • Theranostics.2020;10(17):7645-7655. thnov10p7645. doi: 10.7150/thno.44556.Epub 2020-06-18.

大脳皮質の神経細胞の密度が高く、小脳が大きいため、深海棲の歯付きクジラと比較して、デルフィカイド類の潜水時間が制限されている可能性がある

Higher neuron densities in the cerebral cortex and larger cerebellums may limit dive times of delphinids compared to deep-diving toothed whales.
  • Sam H Ridgway
  • Robert H Brownson
  • Kaitlin R Van Alstyne
  • Robert A Hauser
  • PLoS ONE.2019;14(12):e0226206. PONE-D-19-14471. doi: 10.1371/journal.pone.0226206.Epub 2019-12-16.

マイクロ波を利用した再生透過性反応性バリア(MW-PRB)。概念実証とCs除去への応用

Microwave based regenerating permeable reactive barriers (MW-PRBs): Proof of concept and application for Cs removal.
  • Pietro P Falciglia
  • Erica Gagliano
  • Vincenza Brancato
  • Graziella Malandrino
  • Guglielmo Finocchiaro
  • Alfio Catalfo
  • Guido De Guidi
  • Stefano Romano
  • Paolo Roccaro
  • Federico G A Vagliasindi
  • Chemosphere.2020 Jul;251:126582. S0045-6535(20)30775-X. doi: 10.1016/j.chemosphere.2020.126582.Epub 2020-03-24.

テオドシウス・ドブジャンスキーの生物学と進化に関する見解 v.2.0."生物学では、生物学的性能と多数の多様な短期および長期の保護戦略を最適化するホルミシスを媒介とする後天的な回復力への進化と進化の依存性に照らす以外、何も意味をなさない。"

Theodosius Dobzhansky's view on biology and evolution v.2.0: "Nothing in biology makes sense except in light of evolution and evolution's dependence on hormesis-mediated acquired resilience that optimizes biological performance and numerous diverse short and longer term protective strategies".
  • Edward J Calabrese
  • Evgenios Agathokleous
  • Environ. Res..2020 Jul;186:109559. S0013-9351(20)30452-7. doi: 10.1016/j.envres.2020.109559.Epub 2020-04-21.

ヌクレオチド類似体、EFdA、EdA、EdAPの合成、およびEdAPのB型肝炎ウイルス複製への効果

Synthesis of nucleotide analogues, EFdA, EdA and EdAP, and the effect of EdAP on hepatitis B virus replication.
  • Mai Kamata
  • Toshifumi Takeuchi
  • Ei Hayashi
  • Kazane Nishioka
  • Mizuki Oshima
  • Masashi Iwamoto
  • Kota Nishiuchi
  • Shogo Kamo
  • Shusuke Tomoshige
  • Koichi Watashi
  • Shinji Kamisuki
  • Hiroshi Ohrui
  • Fumio Sugawara
  • Kouji Kuramochi
  • Biosci. Biotechnol. Biochem..2020 Feb;84(2):217-227. doi: 10.1080/09168451.2019.1673696.Epub 2019-10-07.

精巣のトランスクリプトーム解析により、メダカにおけるビスフェノールaまたは17α-エチニルエストラジオールへの発育期曝露の影響が明らかになった

Transcriptome analysis of testis reveals the effects of developmental exposure to bisphenol a or 17α-ethinylestradiol in medaka (Oryzias latipes).
  • Ramji K Bhandari
  • Xuegeng Wang
  • Frederick S Vom Saal
  • Donald E Tillitt
  • Aquat. Toxicol..2020 Jun;225:105553. S0166-445X(20)30303-9. doi: 10.1016/j.aquatox.2020.105553.Epub 2020-06-24.

カムチャッカに生育する狭い固有種であるOxytropis種の根粒菌は、遺伝的多様性に特徴があり、T3SSおよびT6SS分泌系に関連する遺伝子を有しており、共生の発展に影響を与える可能性がある

Rhizobial microsymbionts of the narrowly endemic Oxytropis species growing in Kamchatka are characterized by significant genetic diversity and possess a set of genes that are associated with T3SS and T6SS secretion systems and can affect the development of symbiosis.
  • Vera Safronova
  • Polina Guro
  • Anna Sazanova
  • Irina Kuznetsova
  • Andrey Belimov
  • Valentin Yakubov
  • Elizaveta Chirak
  • Alexey Afonin
  • Yuri Gogolev
  • Evgeny Andronov
  • Igor Tikhonovich
  • Mol. Plant Microbe Interact..2020 Jul;doi: 10.1094/MPMI-05-20-0114-R.Epub 2020-07-20.

リポ多糖は、マクロファージにおけるDrp1依存性のミトコンドリア分裂と関連する炎症反応を促進する

Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages.
  • Ronan Kapetanovic
  • Syeda Farhana Afroz
  • Divya Ramnath
  • Grace Mep Lawrence
  • Takashi Okada
  • James Eb Curson
  • Jost de Bruin
  • David P Fairlie
  • Kate Schroder
  • Justin C St John
  • Antje Blumenthal
  • Matthew J Sweet
  • Immunol. Cell Biol..2020 Jul;doi: 10.1111/imcb.12363.Epub 2020-07-20.

GABA作動性ニューロン上のNMDARの内因性活性を高めることは、抑制を増強し、感覚処理を変化させ、騒音誘発性耳鳴りを予防する

Increasing endogenous activity of NMDARs on GABAergic neurons increases inhibition, alters sensory processing and prevents noise-induced tinnitus.
  • Di Deng
  • Samer Masri
  • Lulu Yao
  • Xiaoyan Ma
  • Xuebing Cao
  • Sungchil Yang
  • Shaowen Bao
  • Qiang Zhou
  • Sci Rep.2020 Jul;10(1):11969. 10.1038/s41598-020-68652-5. doi: 10.1038/s41598-020-68652-5.Epub 2020-07-20.

OTX2-PAX3シグナル伝達軸が3群髄芽腫細胞の運命を制御している

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate.
  • Jamie Zagozewski
  • Ghazaleh M Shahriary
  • Ludivine Coudière Morrison
  • Olivier Saulnier
  • Margaret Stromecki
  • Agnes Fresnoza
  • Gareth Palidwor
  • Christopher J Porter
  • Antoine Forget
  • Olivier Ayrault
  • Cynthia Hawkins
  • Jennifer A Chan
  • Maria C Vladoiu
  • Lakshmikirupa Sundaresan
  • Janilyn Arsenio
  • Michael D Taylor
  • Vijay Ramaswamy
  • Tamra E Werbowetski-Ogilvie
  • Nat Commun.2020 Jul;11(1):3627. 10.1038/s41467-020-17357-4. doi: 10.1038/s41467-020-17357-4.Epub 2020-07-20.

末梢ミエリン蛋白質22が貯蔵作動型カルシウムチャネル活性を調節し、シャルコー・マリー・トゥース病の病因についての洞察を提供する

Peripheral myelin protein 22 modulates store-operated calcium channel activity, providing insights into Charcot-Marie-Tooth disease etiology.
  • Carlos G Vanoye
  • Masayoshi Sakakura
  • Rose M Follis
  • Alexandra J Trevisan
  • Malathi Narayan
  • Jun Li
  • Charles R Sanders
  • Bruce D Carter
  • J. Biol. Chem..2019 08;294(32):12054-12065. RA118.006248. doi: 10.1074/jbc.RA118.006248.Epub 2019-06-18.

深層共晶溶媒中で生成した高分極リチウムリン化物(LiPR2)を室温・大気下でアルデヒド類やエポキシド類に化学選択的に高速添加する

Fast and Chemoselective Addition of in Deep Eutectic Solvent Generated Highly Polarized Lithium Phosphides (LiPR2) to Aldehydes and Epoxides at Room Temperature and Under Air.
  • Joaquin García-Álvarez
  • Luciana Cicco
  • Alba Fombona-Pascual
  • Joaquin García Álvarez
  • Gabino A Carriedo
  • Filippo M Perna
  • Vito Capriati
  • Alejandro Presa Soto
  • Alba Sánchez-Condado
  • ChemSusChem.2020 Jul;doi: 10.1002/cssc.202001449.Epub 2020-07-14.

PpiDとYidCの非競合的なSecYEGトランスロコンへの結合が、大腸菌のSecYEGインタラクトームに関する世界的な視野を広げている

Noncompetitive binding of PpiD and YidC to the SecYEG translocon expands the global view on the SecYEG interactome in .
  • Benjamin Jauss
  • Narcis-Adrian Petriman
  • Friedel Drepper
  • Lisa Franz
  • Ilie Sachelaru
  • Thomas Welte
  • Ruth Steinberg
  • Bettina Warscheid
  • Hans-Georg Koch
  • J. Biol. Chem..2019 12;294(50):19167-19183. RA119.010686. doi: 10.1074/jbc.RA119.010686.Epub 2019-11-07.

COVID -19 で入院し、適応外のヒドロキシクロロキンとアジスロマイシンで治療された患者の臨床転帰と有害事象

Clinical outcomes and adverse events in patients hospitalised with COVID -19, treated with off- label hydroxychloroquine and azithromycin.
  • Mary Kelly
  • Ròisìn O'Connor
  • Liam Townsend
  • Miriam Coghlan
  • Eileen Relihan
  • Miriam Moriarty
  • Bernard Carr
  • Gail Melanophy
  • Caitriona Doyle
  • Ciaran Bannan
  • Ruth O'Riordan
  • Concepta Merry
  • Susie Clarke
  • Colm Bergin
  • Br J Clin Pharmacol.2020 Jul;doi: 10.1111/bcp.14482.Epub 2020-07-20.

メタロシャペロンを用いたチトクロム酸化酵素のCu中心集合体の構造的基盤と機構の解明

Structural basis and mechanism for metallochaperone-assisted assembly of the Cu center in cytochrome oxidase.
  • Fabia Canonica
  • Daniel Klose
  • Raphael Ledermann
  • Maximilian M Sauer
  • Helge K Abicht
  • Nick Quade
  • Alvar D Gossert
  • Serge Chesnov
  • Hans-Martin Fischer
  • Gunnar Jeschke
  • Hauke Hennecke
  • Rudi Glockshuber
  • Sci Adv.2019 07;5(7):eaaw8478. aaw8478. doi: 10.1126/sciadv.aaw8478.Epub 2019-07-31.

多発性脳転移の定位放射線手術に対する単一心室容積変調アーク療法とCyberKnife M6の比較

Single-Isocenter Volumetric Modulated Arc Therapy vs. CyberKnife M6 for the Stereotactic Radiosurgery of Multiple Brain Metastases.
  • Rami A El Shafie
  • Eric Tonndorf-Martini
  • Daniela Schmitt
  • Aylin Celik
  • Dorothea Weber
  • Kristin Lang
  • Laila König
  • Simon Höne
  • Tobias Forster
  • Bastian von Nettelbladt
  • Sebastian Adeberg
  • Jürgen Debus
  • Stefan Rieken
  • Denise Bernhardt
  • Front Oncol.2020;10:568. doi: 10.3389/fonc.2020.00568.Epub 2020-05-08.

COVID-19パンデミック時の頭頸部癌に対する1画分あたり2.4Gyの低屈折率放射線治療単独。プリンセスマーガレットの経験と提案

Hypofractionated radiotherapy alone with 2.4 Gy per fraction for head and neck cancer during the COVID-19 pandemic: The Princess Margaret experience and proposal.
  • Shao Hui Huang
  • Brian O'Sullivan
  • Jie Su
  • Jolie Ringash
  • Scott V Bratman
  • John Kim
  • Ali Hosni
  • Andrew Bayley
  • John Cho
  • Meredith Giuliani
  • Andrew Hope
  • Anna Spreafico
  • Aaron R Hansen
  • Lillian L Siu
  • Ralph Gilbert
  • Jonathan C Irish
  • David Goldstein
  • John de Almeida
  • Li Tong
  • Wei Xu
  • John Waldron
  • Cancer.2020 08;126(15):3426-3437. doi: 10.1002/cncr.32968.Epub 2020-06-01.

ポリープを伴う慢性鼻副鼻腔炎患者の副鼻腔粘膜では、局所好酸球がIgAサブクラスレベルの上昇と関連していることを明らかにした

Local eosinophils are associated with increased IgA subclass levels in the sinonasal mucosa of chronic rhinosinusitis with polyp patients.
  • Hossein Aazami
  • Farhad Seif
  • Babak Ghalehbaghi
  • Pegah Babaheidarian
  • Alireza Mohebbi
  • Aslan Ahmadi
  • Majid Khoshmirsafa
  • Sahand Ghalehbaghi
  • Babak Behnam
  • Kobra Zinat Entezami
  • Zahra Madjd
  • Reza Falak
  • Allergy Asthma Clin Immunol.2020;16:30. 428. doi: 10.1186/s13223-020-00428-y.Epub 2020-04-25.

4'-エチニル-2'-デオキサアデノシン5'-一リン酸アナログであるEdAPの設計、合成、および強力なインフルエンザaインヒビターとしての生物学的評価

Design, Synthesis, and Biological Evaluation of EdAP, a 4'-Ethynyl-2'-Deoxyadenosine 5'-Monophosphate Analog, as a Potent Influenza a Inhibitor.
  • Toshifumi Takeuchi
  • Nongluk Sriwilaijaroen
  • Ayako Sakuraba
  • Ei Hayashi
  • Shinji Kamisuki
  • Yasuo Suzuki
  • Hiroshi Ohrui
  • Fumio Sugawara
  • Molecules.2019 Jul;24(14). E2603. doi: 10.3390/molecules24142603.Epub 2019-07-17.

1957年10月にイギリスのウインズケール工場（セラフィールド）で発生した事故による雲の放射能測定：国際地球物理学年（IGY、1957年7月～1958年12月）に提出されたデータ

Measurements of the radioactivity of the cloud from the accident at Windscale Works (Sellafield, England) in October 1957: data submitted to the International Geophysical Year (IGY; July 1957-December 1958).
  • N G Stewart
  • R N Crooks
  • E M R Fisher
  • J Radiol Prot.2020 Jun;40(2):633-645. doi: 10.1088/1361-6498/ab70cc.Epub 2020-05-27.

ニュージーランド水域のアローイカ（Nototodarus gouldi, N. sloanii）の微量元素濃度の地域的評価。生物学的アクセス性と食物網と人間の消費者への影響

Regional assessment of trace element concentrations in arrow squids (Nototodarus gouldi, N. sloanii) from New Zealand waters: Bioaccessibility and impact on food web and human consumers.
  • A Lischka
  • H E Braid
  • J L Pannell
  • C J Pook
  • S Gaw
  • M Yoo
  • K S R Bolstad
  • Environ. Pollut..2020 Sep;264:114662. S0269-7491(19)37625-0. doi: 10.1016/j.envpol.2020.114662.Epub 2020-04-24.

ペネヒクリジン塩酸塩の前投薬は、手術後の認知機能障害やせん妄の発生率の増加とは関連していません：A Systemic Review and Meta-Analysis（全身レビューとメタアナリシス）

Penehyclidine Hydrochloride Premedication Is Not Associated with Increased Incidence of Post-Operative Cognitive Dysfunction or Delirium:A Systemic Review and Meta-Analysis.
  • Yun Tai Yao
  • Hua Ying
  • Neng Xin Fang
  • Yong Bao Zhang
  • Xin Yuan
  • Chin. Med. Sci. J..2020 Jun;35(2):121-134. 3630. doi: 10.24920/003630.

線維性膵臓糖尿病患者を対象とした生体電気インピーダンス分析による腹腔内脂肪の推定を、BMIをマッチさせた2型糖尿病患者および健常対照者と比較した

Intra-abdominal fat estimation by bio-electrical impedance analysis in patients with fibrocalculous pancreatic diabetes compared with BMI matched type 2 diabetic subjects and healthy controls.
  • Channabasappa Shivaprasad
  • Kolla Gautham
  • Preethika Palani
  • Soumya Gupta
  • Kejal Shah
  • Diabetes Metab Syndr.2020 May;14(5):789-795. S1871-4021(20)30157-0. doi: 10.1016/j.dsx.2020.05.038.Epub 2020-05-27.

キャピラリーエレクトロクロマトグラフィーエナンチオ分離のためのチオール類β-シクロデキストリン/金ナノ粒子被覆開放管状カラムの調製

Preparation of a thiols β-cyclodextrin/gold nanoparticles-coated open tubular column for capillary electrochromatography enantioseparations.
  • Linlin Fang
  • Yanyan Zhao
  • Chao Wang
  • Changyuan Wang
  • Xu Han
  • Pengjun Chen
  • Lizhu Zhao
  • Jingping Wang
  • Shuang Li
  • Zhen Jiang
  • J Sep Sci.2020 Jun;43(11):2209-2216. doi: 10.1002/jssc.201901323.Epub 2020-04-13.

駒形ella phaffii（Pichia pastoris）の亜鉛ホメオスタシスのために、グリセロールトランスポーター1（Gt1）と亜鉛調節トランスポーター1（Zrt1）が異なるモードで機能していることを明らかにした

Glycerol transporter 1 (Gt1) and zinc-regulated transporter 1 (Zrt1) function in different modes for zinc homeostasis in Komagataella phaffii (Pichia pastoris).
  • Yankun Yang
  • Yingyue Pan
  • Guoqiang Liu
  • Guibin Dong
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  • Mattheos A G Koffas
  • Xiuxia Liu
  • Ye Li
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アスペルギルス・フミガタスの減少したエキノカンジン感受性に関連するFKS1変異は、アニデュラファンジン暴露に続く

FKS1 mutation associated with decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure.
  • Ana Pinto E Silva
  • Isabel Marcos Miranda
  • Joana Branco
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  • Acácio Gonçalves Rodrigues
  • Sofia Costa-de-Oliveira
  • Sci Rep.2020 Jul;10(1):11976. 10.1038/s41598-020-68706-8. doi: 10.1038/s41598-020-68706-8.Epub 2020-07-20.

潜在的な抗がん剤ターゲットとしてhNTH1-YB1インターフェースをターゲットとするためのフェルスター共鳴エネルギー移動ベースのバイオセンサー

Förster Resonance Energy Transfer Based Biosensor for Targeting the hNTH1-YB1 Interface as a Potential Anticancer Drug Target.
  • Muge Senarisoy
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  • Françoise Lacroix
  • Salvatore De Bonis
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  • Fabienne Hans
  • Jean-Philippe Kleman
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  • ACS Chem. Biol..2020 04;15(4):990-1003. doi: 10.1021/acschembio.9b01023.Epub 2020-03-17.

イミダゾール系アルカロイドはヒト好中球のプロ炎症機構を阻害し、インビボで抗炎症作用を示す

Imidazole alkaloids inhibit the pro-inflammatory mechanisms of human neutrophil and exhibit anti-inflammatory properties in vivo.
  • Talita Magalhães Rocha
  • Nuno J Machado
  • João Antonio Costa de Sousa
  • Emmanuel Vinicius Oliveira Araujo
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  • Luzia Kalyne Almeida Moreira Leal
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アクチンとの静電的相互作用の増加を介した2-デオキシ-ATPによる心筋ミオシンの活性化

Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin.
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  • Chen-Ching Yuan
  • Kimberly J McCabe
  • Jason D Murray
  • Matthew Carter Childers
  • Galina V Flint
  • Farid Moussavi-Harami
  • Saffie Mohran
  • Romi Castillo
  • Carla Zuzek
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  • Michael Regnier
  • Proc. Natl. Acad. Sci. U.S.A..2019 06;116(23):11502-11507. 1905028116. doi: 10.1073/pnas.1905028116.Epub 2019-05-20.

移植後シクロホスファミドを用いた低強度条件付け移植後の転帰に末梢血CD34+およびCD3+移植片細胞数の影響は認められなかった

Absence of influence of peripheral blood CD34+ and CD3+ graft cell counts on outcomes after reduced-intensity conditioning transplantation using post-transplant cyclophosphamide.
  • Alice Garnier
  • Thierry Guillaume
  • Pierre Peterlin
  • Amandine Le Bourgeois
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  • Cyrille Touzeau
  • Thomas Gastinne
  • Anne Lok
  • Benoit Tessoulin
  • Alix Duquesne
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三陰性マトリックス産生乳癌患者由来の同所性異種移植片（PDOX）マウスモデルは、ベバシズマブおよびビノレルビンに対して感受性があり、エリブリンによって退縮し、オラパリブに対して抵抗性である

A Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft (PDOX) Mouse Model Is Sensitive to Bevacizumab and Vinorelbine, Regressed by Eribulin and Resistant to Olaparib.
  • Jun Yamamoto
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  • Hiroto Nishino
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  • Y U Sun
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  • Kentaro Miyake
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  • Tsunehisa Nomura
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  • Takuya Moriya
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  • Chihiro Hozumi
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  • Anticancer Res..2020 May;40(5):2509-2514. 40/5/2509. doi: 10.21873/anticanres.14221.

VEGF、PlGF、sFlt-1の血清レベルは、妊娠中の活動性エリテマトーデス腎炎と子癇前症の鑑別を可能にします

VEGF, PlGF and sFlt-1 serum levels allow differentiation between active lupus nephritis during pregnancy and preeclampsia.
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  • Marcela I Lacerda
  • Bruna C Rodrigues
  • Flávia C Dos Santos
  • Adriana P do Nascimento
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  • Arthritis Care Res (Hoboken).2020 Jun;doi: 10.1002/acr.24360.Epub 2020-06-25.

ブラジル北東部の熱帯セルジペ-ポキシム河口系における人為的活動の影響。糞便指標

The impact of anthropogenic activity at the tropical Sergipe-Poxim estuarine system, Northeast Brazil: Fecal indicators.
  • Michel Rubens Dos Reis Souza
  • Ewerton Santos
  • Jaiane Santos Suzarte
  • Laiane Oliveira do Carmo
  • Laiane Santos Soares
  • Lukas Gomes Gadelha Vieira Santos
  • Antônio Rodrigues Vilela Júnior
  • Laiza Canielas Krause
  • Morgana Frena
  • Flaviana Cardoso Damasceno
  • Yongsong Huang
  • Marcelo da Rosa Alexandre
  • Mar. Pollut. Bull..2020 May;154:111067. S0025-326X(20)30185-5. doi: 10.1016/j.marpolbul.2020.111067.Epub 2020-03-24.

インスリン受容体の発現を部分的に障害すると、食事誘発性脂肪肝疾患を予防するために絶食を模倣する

Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease.
  • Troy L Merry
  • Chris P Hedges
  • Stewart W Masson
  • Beate Laube
  • Doris Pöhlmann
  • Stephan Wueest
  • Michael E Walsh
  • Myrtha Arnold
  • Wolfgang Langhans
  • Daniel Konrad
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  • Nat Commun.2020 04;11(1):2080. 10.1038/s41467-020-15623-z. doi: 10.1038/s41467-020-15623-z.Epub 2020-04-29.

LMWフコイダンによる活性化ヒト多形核好中球の微粒子放出とプロ炎症特性のダウンレギュレーション

Downregulation of Microparticle Release and Pro-Inflammatory Properties of Activated Human Polymorphonuclear Neutrophils by LMW Fucoidan.
  • João Alfredo Moraes
  • Ana Clara Frony
  • Pedro Barcellos-de-Souza
  • Marcel Menezes da Cunha
  • Thayanne Brasil Barbosa Calcia
  • Claudia Farias Benjamim
  • Catherine Boisson-Vidal
  • Christina Barja-Fidalgo
  • J Innate Immun.2019;11(4):330-346. 000494220. doi: 10.1159/000494220.Epub 2018-12-17.

アンチセンスオリゴヌクレオチドを用いた転写からスプライシングをアンカップリングすることで、抗体クラス切り替えにおける I エクソンドナースプライスサイトの二重の役割が明らかに

Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching.
  • Anne Marchalot
  • Mohamad Omar Ashi
  • Jean-Marie Lambert
  • Claire Carrion
  • Sandrine Lecardeur
  • Nivine Srour
  • Laurent Delpy
  • Soazig Le Pennec
  • Front Immunol.2020;11:780. doi: 10.3389/fimmu.2020.00780.Epub 2020-05-08.

ゲルろ過クロマトグラフィーを用いたフリーフロー電気泳動による卵白中の低容量リゾチームの精製

Purification of low-abundance lysozyme in egg white via free-flow electrophoresis with gel-filtration chromatography.
  • Shuang Dong
  • Ziqin Jiang
  • Zhen Liu
  • Ling Chen
  • Qiang Zhang
  • Youli Tian
  • Amir Sohail
  • Muhammad Idrees Khan
  • Hua Xiao
  • Xiaoping Liu
  • Yuxing Wang
  • Honggen Li
  • Hanyu Wu
  • Weiwen Liu
  • Chengxi Cao
  • Electrophoresis.2020 Jun;doi: 10.1002/elps.201900479.Epub 2020-06-12.

パエオニフローリンは、Nrf2/ARE経路を活性化し、アポトーシスを抑制することで、高グルコースによる酸化傷害からシュワン細胞を保護します

Paeoniflorin protects Schwann cells against high glucose induced oxidative injury by activating Nrf2/ARE pathway and inhibiting apoptosis.
  • Xinwei Yang
  • Weijie Yao
  • Haotian Shi
  • Haolong Liu
  • Yangfan Li
  • Yanbin Gao
  • Renhui Liu
  • Liping Xu
  • J Ethnopharmacol.2016 Jun;185:361-9. S0378-8741(16)30129-5. doi: 10.1016/j.jep.2016.03.031.Epub 2016-03-12.

生殖型コハク酸脱水素酵素遺伝子変異の腫瘍スペクトルのレビュー。褐色細胞腫と傍神経節腫を超えて

A review of the tumour spectrum of germline succinate dehydrogenase gene mutations: Beyond phaeochromocytoma and paraganglioma.
  • James MacFarlane
  • Keat Cheah Seong
  • Chad Bisamber
  • Basetti Madhu
  • Kieren Allinson
  • Alison Marker
  • Anne Warren
  • Soo-Mi Park
  • Olivier Giger
  • Benjamin G Challis
  • Eamonn R Maher
  • Ruth T Casey
  • Clin. Endocrinol. (Oxf).2020 Jul;doi: 10.1111/cen.14289.Epub 2020-07-19.

チアミン塩酸塩を有機触媒として用いることで、ビス(インドリル)メタンスの効率的かつグリーンな合成が可能となる。水中でのマイクロ波照射と超音波加熱の並行検討

Efficient and green synthesis of Bis(indolyl)methanes using Thiamine hydrochloride as an organocatalyst: A Parallel Scrutiny of Microwave Irradiation versus Ultrasonicator heating in Water.
  • Nitin M Thorat
  • Kiran D Dhawale
  • Sandeep B Kasar
  • Manali S Thopate
  • Limbraj R Patil
  • Shankar R Thopate
  • Curr Org Synth.2020 Jun;COS-EPUB-107503. doi: 10.2174/1570179417666200620215101.Epub 2020-06-20.

妊娠中の低タンパク質母体の食事は、ラットにおける男性の受胎可能性マーカーに負の影響を持っている - システマティックレビューとメタアナリシス

A low protein maternal diet during gestation has negative effects on male fertility markers in rats - A Systematic Review and Meta-analysis.
  • Peter K Ajuogu
  • Mohammed A K Al-Aqbi
  • Robert A Hart
  • James R McFarlane
  • Neil A Smart
  • J Anim Physiol Anim Nutr (Berl).2020 Jul;doi: 10.1111/jpn.13411.Epub 2020-07-12.

Spenは、RNAが媒介する内因性レトロウイルスのサイレンシングとX染色体の不活性化をリンクしています

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation.
  • Ava C Carter
  • Jin Xu
  • Meagan Y Nakamoto
  • Yuning Wei
  • Brian J Zarnegar
  • Quanming Shi
  • James P Broughton
  • Ryan C Ransom
  • Ankit Salhotra
  • Surya D Nagaraja
  • Rui Li
  • Diana R Dou
  • Kathryn E Yost
  • Seung-Woo Cho
  • Anil Mistry
  • Michael T Longaker
  • Paul A Khavari
  • Robert T Batey
  • Deborah S Wuttke
  • Howard Y Chang
  • Elife.2020 May;9. e54508. doi: 10.7554/eLife.54508.Epub 2020-05-07.

イソフラボンの抗炎症性および抗酸化性は、糖尿病性腎症に対する食事性大豆たんぱく質とは異なる腎保護効果を提供する

Anti-Inflammatory and Antioxidative Properties of Isoflavones Provide Renal Protective Effects Distinct from Those of Dietary Soy Proteins against Diabetic Nephropathy.
  • Huei-Fen Jheng
  • Kanako Hayashi
  • Yasuki Matsumura
  • Teruo Kawada
  • Shigeto Seno
  • Hideo Matsuda
  • Kazuo Inoue
  • Wataru Nomura
  • Haruya Takahashi
  • Tsuyoshi Goto
  • Mol Nutr Food Res.2020 May;64(10):e2000015. doi: 10.1002/mnfr.202000015.Epub 2020-04-27.

骨折リスクの高い閉経後女性における骨粗鬆症治療薬であるクレロスティン阻害薬ロモゾズマブの非臨床心血管安全性評価について

Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture.
  • James R Turk
  • Aimee M Deaton
  • Jun Yin
  • Marina Stolina
  • Melanie Felx
  • Gabrielle Boyd
  • Jean-Guy Bienvenu
  • Aurore Varela
  • Martin Guillot
  • Gill Holdsworth
  • Alison Wolfreys
  • Denise Dwyer
  • Sheetal V Kumar
  • Emily M de Koning
  • Yusheng Qu
  • Michael Engwall
  • Kathrin Locher
  • Lucas D Ward
  • Charles Glaus
  • Yudong D He
  • Rogely Waite Boyce
  • Regul. Toxicol. Pharmacol..2020 Jun;115:104697. S0273-2300(20)30123-9. doi: 10.1016/j.yrtph.2020.104697.Epub 2020-06-23.

継続するか、しないか？初回エピソード精神病における抗精神病薬の服薬維持と減量・中止：HAMLETT（実用的な多施設共同単盲検無作為化比較試験

To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis: HAMLETT, a pragmatic multicenter single-blind randomized controlled trial.
  • Marieke J H Begemann
  • Ilse A Thompson
  • Wim Veling
  • Shiral S Gangadin
  • Chris N W Geraets
  • Erna van 't Hag
  • Sanne J Müller-Kuperus
  • Priscilla P Oomen
  • Alban E Voppel
  • Mark van der Gaag
  • Martijn J Kikkert
  • Jim Van Os
  • H Filip E Smit
  • Rikus H Knegtering
  • Sybren Wiersma
  • Luyken H Stouten
  • Harm J Gijsman
  • Lex Wunderink
  • Anton B P Staring
  • Selene R T Veerman
  • Amrita G S Mahabir
  • Jörg Kurkamp
  • Gerdina H M Pijnenborg
  • Natalie D Veen
  • Machteld Marcelis
  • Koen P Grootens
  • Gunnar Faber
  • Nico J van Beveren
  • Agaath Been
  • Truus van den Brink
  • Maarten Bak
  • Therese A M J van Amelsvoort
  • Andrea Ruissen
  • Christine Blanke
  • Karin Groen
  • Lieuwe de Haan
  • Iris E C Sommer
  • Trials.2020 Feb;21(1):147. 10.1186/s13063-019-3822-5. doi: 10.1186/s13063-019-3822-5.Epub 2020-02-07.

GATAD2B-Associated Neurodevelopmental Disorder（GAND）患者19人の臨床および分子レベルでの説明

Clinical and molecular description of 19 patients with GATAD2B-Associated Neurodevelopmental Disorder (GAND).
  • Gabriella Vera
  • Arthur Sorlin
  • Geoffroy Delplancq
  • François Lecoquierre
  • Marie Brasseur-Daudruy
  • Florence Petit
  • Thomas Smol
  • Alban Ziegler
  • Dominique Bonneau
  • Estelle Colin
  • Sandra Mercier
  • Benjamin Cogné
  • Stéphane Bézieau
  • Patrick Edery
  • Gaetan Lesca
  • Nicolas Chatron
  • Isabelle Sabatier
  • Bénédicte Duban-Bedu
  • Cindy Colson
  • Amélie Piton
  • Benjamin Durand
  • Yline Capri
  • Laurence Perrin
  • Antje Wiesener
  • Christiane Zweier
  • Reza Maroofian
  • Christopher J Carroll
  • Hamid Galehdari
  • Neda Mazaheri
  • Bert Callewaert
  • Fabienne Giulianno
  • Khaoula Zaafrane-Khachnaoui
  • Rebecca Buchert-Lo
  • Tobias Haack
  • Janine Magg
  • Angelika Rieß
  • Maria Blandfort
  • Stephan Waldmüller
  • Veronka Horber
  • Emanuela Leonardi
  • Roberta Polli
  • Licia Turolla
  • Alessandra Murgia
  • Thierry Frebourg
  • Anne Sophie Lebre
  • Gaël Nicolas
  • Pascale Saugier-Veber
  • Anne-Marie Guerrot
  • Eur J Med Genet.2020 Jul;:104004. S1769-7212(20)30507-3. doi: 10.1016/j.ejmg.2020.104004.Epub 2020-07-17.

PDE5阻害はTie2発現単球とアンジオポエチン-1を刺激し、糖尿病における血管新生の恒常性を回復させる

PDE5 Inhibition Stimulates Tie2-Expressing Monocytes and Angiopoietin-1 Restoring Angiogenic Homeostasis in Diabetes.
  • Mary Anna Venneri
  • Federica Barbagallo
  • Daniela Fiore
  • Rita De Gaetano
  • Elisa Giannetta
  • Emilia Sbardella
  • Carlotta Pozza
  • Federica Campolo
  • Fabio Naro
  • Andrea Lenzi
  • Andrea M Isidori
  • J. Clin. Endocrinol. Metab..2019 07;104(7):2623-2636. 5376632. doi: 10.1210/jc.2018-02525.

新規分子インプリント電気化学センサーを用いたコレスタノールの超高感度インピメトリー・ボルタンメトリー定量技術の開発

An elegant technology for ultrasensitive impedimetric and voltammetric determination of cholestanol based on a novel molecularly imprinted electrochemical sensor.
  • Ali R Jalalvand
  • Mohammad Mahdi Zangeneh
  • Faramarz Jalili
  • Shokoufeh Soleimani
  • Jose Manuel Díaz-Cruz
  • Chem. Phys. Lipids.2020 Jul;229:104895. S0009-3084(20)30026-8. doi: 10.1016/j.chemphyslip.2020.104895.Epub 2020-03-09.

設計上の特徴やその他の要因は、どのように入院患者の室内空気の質に影響を与えることができるか？化学物質汚染の空気濃度を低減するための設計段階、日常の手順、メンテナンス活動のチェックリスト

How Can Design Features and Other Factors Affect the Indoor Air Quality in Inpatient Rooms? Check-Lists for the Design Phase, Daily Procedures and Maintenance Activities for Reducing the Air Concentrations of Chemical Pollution.
  • Marco Gola
  • Gaetano Settimo
  • Stefano Capolongo
  • Int J Environ Res Public Health.2020 Jun;17(12). E4280. doi: 10.3390/ijerph17124280.Epub 2020-06-15.

好中球生物学における性差は、I型インターフェロンおよび免疫代謝に対する応答を調節する

Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism.
  • Sarthak Gupta
  • Shuichiro Nakabo
  • Luz P Blanco
  • Liam J O'Neil
  • Gustaf Wigerblad
  • Rishi R Goel
  • Pragnesh Mistry
  • Kan Jiang
  • Carmelo Carmona-Rivera
  • Diana W Chan
  • Xinghao Wang
  • Hege L Pedersen
  • Manasi Gadkari
  • Katherine N Howe
  • Faiza Naz
  • Stefania Dell'Orso
  • Sarfaraz A Hasni
  • Caeden Dempsey
  • Ashley Buscetta
  • Pamela A Frischmeyer-Guerrerio
  • Paul Kruszka
  • Maximilian Muenke
  • Luis M Franco
  • Hong-Wei Sun
  • Mariana J Kaplan
  • Proc. Natl. Acad. Sci. U.S.A..2020 Jul;117(28):16481-16491. 2003603117. doi: 10.1073/pnas.2003603117.Epub 2020-06-29.

実験的てんかんにおけるP2Y受容体の抗てんかん作用からプロてんかん作用への文脈特異的な切り替え

Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y Receptor in Experimental Epilepsy.
  • Mariana Alves
  • Laura De Diego Garcia
  • Giorgia Conte
  • Eva M Jimenez-Mateos
  • Beatrice D'Orsi
  • Amaya Sanz-Rodriguez
  • Jochen H M Prehn
  • David C Henshall
  • Tobias Engel
  • J. Neurosci..2019 07;39(27):5377-5392. JNEUROSCI.0089-19.2019. doi: 10.1523/JNEUROSCI.0089-19.2019.Epub 2019-05-02.

Brighton Collaborationは、タンパク質ワクチンのベネフィットリスク評価のための重要情報収集のための標準化されたテンプレートを提供しています

The Brighton Collaboration standardized template for collection of key information for benefit-risk assessment of protein vaccines.
  • Sonali Kochhar
  • Denny Kim
  • Jean-Louis Excler
  • Richard C Condit
  • James S Robertson
  • Stephen Drew
  • Mike Whelan
  • David Wood
  • Patricia E Fast
  • Marc Gurwith
  • Bettina Klug
  • Najwa Khuri-Bulos
  • Emily R Smith
  • Robert T Chen
  • Vaccine.2020 Jul;S0264-410X(20)30830-6. doi: 10.1016/j.vaccine.2020.06.044.Epub 2020-07-08.

p38 MAPKのリン酸化は、マウスにおけるBcl-xLのミトコンドリア転座を介した低酸素前処理による脳虚血性障害に対する神経保護を媒介している

Phosphorylation of p38 MAPK mediates hypoxic preconditioning-induced neuroprotection against cerebral ischemic injury via mitochondria translocation of Bcl-xL in mice.
  • Li Zhao
  • Xu Liu
  • Jing Liang
  • Song Han
  • Yue Wang
  • Yanling Yin
  • Yanlin Luo
  • Junfa Li
  • Brain Res..2013 Mar;1503:78-88. S0006-8993(13)00188-1. doi: 10.1016/j.brainres.2013.01.051.Epub 2013-02-08.

ZrOナノフィルムでコーティングされたZn-Li合金の制御可能な生分解と強化されたオッセオインテグレーション。インビトロおよびインビボでの研究

Controllable biodegradation and enhanced osseointegration of ZrO-nanofilm coated Zn-Li alloy: In vitro and in vivo studies.
  • Wei Yuan
  • Dandan Xia
  • Yufeng Zheng
  • Xiangmei Liu
  • Shuilin Wu
  • Bo Li
  • Yong Han
  • Zhaojun Jia
  • Donghui Zhu
  • Liqun Ruan
  • Kazuki Takashima
  • Yunsong Liu
  • Yongsheng Zhou
  • Acta Biomater.2020 03;105:290-303. S1742-7061(20)30036-2. doi: 10.1016/j.actbio.2020.01.022.Epub 2020-01-20.

グルコサミン-6-リン酸合成酵素阻害剤としてのナリンゲニン誘導体：合成、抗酸化作用、抗菌作用、防腐効果、分子ドッキング、インシリコADMET解析

Naringenin derivatives as glucosamine-6-phosphate synthase inhibitors: synthesis, antioxidants, antimicrobial, preservative efficacy, molecular docking and in silico ADMET analysis.
  • Amit Lather
  • Sunil Sharma
  • Anurag Khatkar
  • BMC Chem.2020 Dec;14(1):41. 693. doi: 10.1186/s13065-020-00693-3.Epub 2020-06-19.

タピナンサス・グロビフェラスの抗けいれん作用におけるベンゾジアゼピン部位の関与について

Involvement of the Benzodiazepine Site in the Anticonvulsant Activity of Tapinanthus globiferus against Pentylenetetrazole-induced Seizures in Mice.
  • Christianah A Elusiyan
  • Ana Luiza Gonçalves Faria
  • Ane Emanuelle Queiroga Mendes
  • Iransé Oliveira Silva
  • José Luis Rodrigues Martins
  • Daniel Alves Rosa
  • Gustavo Rodrigues Pedrino
  • Elson Alves Costa
  • Mohamed Ali Ibrahim
  • Jordan K Zjawiony
  • James Oluwagbamigbe Fajemiroye
  • Planta Med..2020 Jul;doi: 10.1055/a-1209-1254.Epub 2020-07-15.

Plasmodium falciparum と Plasmodium knowlesi の無性血液ステージ寄生虫の迅速、単純かつ正確な同期化のための高度に特異的なキナーゼ阻害剤の使用

Use of a highly specific kinase inhibitor for rapid, simple and precise synchronization of Plasmodium falciparum and Plasmodium knowlesi asexual blood-stage parasites.
  • Margarida Ressurreição
  • James A Thomas
  • Stephanie D Nofal
  • Christian Flueck
  • Robert W Moon
  • David A Baker
  • Christiaan van Ooij
  • PLoS ONE.2020;15(7):e0235798. PONE-D-20-12341. doi: 10.1371/journal.pone.0235798.Epub 2020-07-16.

オキサリプラチン誘発性末梢神経障害に対するシスチンおよびテアニンの経口投与の保護効果：パイロット無作為化試験

Protective effect of the oral administration of cystine and theanine on oxaliplatin-induced peripheral neuropathy: a pilot randomized trial.
  • Minoru Kobayashi
  • Ryuichiro Sato
  • Toshihiro Komura
  • Hidetaka Ichikawa
  • Tomoaki Hirashima
  • Satoshi Otake
  • Naoya Akazawa
  • Takashi Yazawa
  • Tomoya Abe
  • Takaho Okada
  • Tetsuya Kakita
  • Masaya Oikawa
  • Takashi Tsuchiya
  • Int. J. Clin. Oncol..2020 Jun;10.1007/s10147-020-01728-4. doi: 10.1007/s10147-020-01728-4.Epub 2020-06-27.

抗糸球体基底膜抗体陽性糸球体腎炎に極小変化疾患が重なったネフローゼ症候群の一例

Nephrotic syndrome due to minimal-change disease superimposed on anti-glomerular basement membrane antibody positive glomerulonephritis; a case report.
  • Yuko Shibata
  • Kazuhito Fukuoka
  • Riyo Yokota
  • Heryon Lee
  • Hikaru Sayo
  • Noriko Ikegaya
  • Kiyotaka Mori
  • Jin Yamamoto
  • Aya Isomura
  • Kiyotaka Nagahama
  • Hiroaki Shimoyamada
  • Takahisa Kawakami
  • Yoshinori Komagata
  • Shinya Kaname
  • BMC Nephrol.2020 Jul;21(1):283. 10.1186/s12882-020-01947-x. doi: 10.1186/s12882-020-01947-x.Epub 2020-07-17.

トラスツズマブ耐性の転移性食道-胃接合部/胃癌患者を対象としたFGFR阻害剤ペミガチニブの第Ⅱ相試験：FiGhTeR試験

A phase II trial of the FGFR inhibitor pemigatinib in patients with metastatic esophageal-gastric junction/gastric cancer trastuzumab resistant: the FiGhTeR trial.
  • Valeria Merz
  • Camilla Zecchetto
  • Francesca Simionato
  • Alessandro Cavaliere
  • Simona Casalino
  • Michele Pavarana
  • Simone Giacopuzzi
  • Maria Bencivenga
  • Anna Tomezzoli
  • Raffaela Santoro
  • Vita Fedele
  • Serena Contarelli
  • Irene Rossi
  • Serena Giacomazzi
  • Martina Pasquato
  • Cristiana Piazzola
  • Stefano Milleri
  • Giovanni de Manzoni
  • Davide Melisi
  • Ther Adv Med Oncol.2020;12:1758835920937889. 10.1177_1758835920937889. doi: 10.1177/1758835920937889.Epub 2020-07-07.

バラの海と人間の健康講座。海洋と人間の健康問題に一般市民を巻き込む新しい方法

The Roses Ocean and Human Health Chair: A New Way to Engage the Public in Oceans and Human Health Challenges.
  • Josep Lloret
  • Rafael Abós-Herràndiz
  • Sílvia Alemany
  • Rosario Allué
  • Joan Bartra
  • Maria Basagaña
  • Elisa Berdalet
  • Mònica Campàs
  • Arnau Carreño
  • Montserrat Demestre
  • Jorge Diogène
  • Eva Fontdecaba
  • Mireia Gascon
  • Sílvia Gómez
  • Angel Izquierdo
  • Lluïsa Mas
  • Montse Marquès
  • Juan Pedro-Botet
  • Maria Pery
  • Francesc Peters
  • Xavier Pintó
  • Marta Planas
  • Ana Sabatés
  • Joan San
  • Anna Sanchez-Vidal
  • Martí Trepat
  • Cristina Vendrell
  • Lora E Fleming
  • Int J Environ Res Public Health.2020 Jul;17(14). E5078. doi: 10.3390/ijerph17145078.Epub 2020-07-14.

ニジマス（Oncorhynchus mykiss）の腸管透過性を評価するために、大豆粕による炎症の有無に関わらず、腸管透過性を評価することを目的とした実験を行った

Bacterial translocation and in vivo assessment of intestinal barrier permeability in rainbow trout (Oncorhynchus mykiss) with and without soyabean meal-induced inflammation.
  • Peyman Mosberian-Tanha
  • Margareth Øverland
  • Thor Landsverk
  • Felipe E Reveco
  • Johan W Schrama
  • Andries J Roem
  • Jane W Agger
  • Liv T Mydland
  • J Nutr Sci.2016;5:e26. 00007. doi: 10.1017/jns.2016.7.Epub 2016-06-06.

コーン機能障害における色覚の定量化のための新しい技術：ヘテロ接合型RP1L1およびRPGR変異患者におけるケンブリッジカラーテストと視細胞特異的時間的コントラスト感度

[New techniques for quantification of color vision in disorders of cone function : Cambridge color test and photoreceptor-specific temporal contrast sensitivity in patients with heterozygous RP1L1 and RPGR mutations].
  • Cord Huchzermeyer
  • Julien Fars
  • Heidi Stöhr
  • Jan Kremers
  • Ophthalmologe.2020 May;10.1007/s00347-020-01119-0. doi: 10.1007/s00347-020-01119-0.Epub 2020-05-26.

多発性骨髄腫の抗原特異的免疫療法のためのB細胞成熟化抗原由来T細胞エピトープの質量分析による同定

Mass spectrometry-based identification of a B-cell maturation antigen-derived T-cell epitope for antigen-specific immunotherapy of multiple myeloma.
  • Tatjana Bilich
  • Annika Nelde
  • Jens Bauer
  • Simon Walz
  • Malte Roerden
  • Helmut R Salih
  • Katja Weisel
  • Britta Besemer
  • Ana Marcu
  • Maren Lübke
  • Juliane Schuhmacher
  • Marian C Neidert
  • Hans-Georg Rammensee
  • Stefan Stevanović
  • Juliane S Walz
  • Blood Cancer J.2020 02;10(2):24. 10.1038/s41408-020-0288-3. doi: 10.1038/s41408-020-0288-3.Epub 2020-02-28.

自閉症スペクトラム障害におけるサイトカイン発現プロファイル．トルコからの多施設共同研究

Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey.
  • Meryem Ozlem Kutuk
  • Evren Tufan
  • Cem Gokcen
  • Fethiye Kilicaslan
  • Mehmet Karadag
  • Tuba Mutluer
  • Cigdem Yektas
  • Nurdan Coban
  • Hasan Kandemir
  • Ahmet Buber
  • Seyma Coskun
  • Ufuk Acikbas
  • Gulen Guler
  • Zehra Topal
  • Fatma Celik
  • Ebru Altintas
  • Aslı Giray
  • Yeliz Aka
  • Ozgur Kutuk
  • Cytokine.2020 Jun;133:155152. S1043-4666(20)30168-X. doi: 10.1016/j.cyto.2020.155152.Epub 2020-06-18.

視覚的なフードキューは、正常体重および肥満男性を対象とした経口耐糖能試験後の血糖値およびグルコース調節ホルモンを低下させる

Visual food cues decrease blood glucose and glucoregulatory hormones following an oral glucose tolerance test in normal-weight and obese men.
  • Swantje Brede
  • Birte Lutzke
  • Elena Albers
  • Chiara Dalla-Man
  • Claudio Cobelli
  • Manfred Hallschmid
  • Johanna Klement
  • Hendrik Lehnert
  • Physiol. Behav..2020 Jul;:113071. S0031-9384(20)30385-1. doi: 10.1016/j.physbeh.2020.113071.Epub 2020-07-10.

Cbfβの軟骨細胞特異的ノックアウトにより、マウスにおける軟骨細胞の成熟、成長板の発達、海綿骨形成にCbfβが不可欠な機能を持つことが明らかになった

Chondrocyte-specific knockout of Cbfβ reveals the indispensable function of Cbfβ in chondrocyte maturation, growth plate development and trabecular bone formation in mice.
  • Mengrui Wu
  • Yi-Ping Li
  • Guochun Zhu
  • Yun Lu
  • Yiping Wang
  • Joel Jules
  • Matthew McConnell
  • Rosa Serra
  • Jian-Zhong Shao
  • Wei Chen
  • Int. J. Biol. Sci..2014;10(8):861-72. ijbsv10p0861. doi: 10.7150/ijbs.8521.Epub 2014-07-29.

臼蓋周囲関節感染症の診断 .AE-(German Society for Arthroplasty)のインプラント関連感染症研究会によるエビデンスに基づいたアルゴリズムの開発

[Diagnosis of periprosthetic joint infection : Development of an evidence-based algorithm by the work group of implant-associated infection of the AE-(German Society for Arthroplasty)].
  • H Mühlhofer
  • N Renz
  • A Zahar
  • M Lüdemann
  • M Rudert
  • R Hube
  • L Frommelt
  • R Ascherl
  • C Perka
  • R von Eisenhart-Rothe
  • Orthopade.2020 Jul;10.1007/s00132-020-03940-6. doi: 10.1007/s00132-020-03940-6.Epub 2020-07-14.

低リン血症性くる病を患った24ヶ月の男児における、標的遺伝子パネルシークエンスを用いたPHEX遺伝子の新規変異体の同定

Identification of a novel variant in the PHEX gene using targeted gene panel sequencing in a 24-month-old boy with hypophosphatemic rickets.
  • Ha Young Jo
  • Jung Hyun Shin
  • Hye Young Kim
  • Young Mi Kim
  • Heirim Lee
  • Mi Hye Bae
  • Kyung Hee Park
  • Ja-Hyun Jang
  • Min Jung Kwak
  • Ann Pediatr Endocrinol Metab.2020 Mar;25(1):63-67. apem.2020.25.1.63. doi: 10.6065/apem.2020.25.1.63.Epub 2020-03-31.

ピレスロイド系殺虫剤エスフェンバレレートは、ゼブラフィッシュ（Danio rerio）の胚性/雄性ゼブラフィッシュにおいて、低活性化を誘導し、ドーパミントランスポーターの発現を低下させる

The pyrethroid esfenvalerate induces hypoactivity and decreases dopamine transporter expression in embryonic/larval zebrafish (Danio rerio).
  • Xiao H Wang
  • Christopher L Souders
  • Priscilla Xavier
  • Xiao Y Li
  • Bing Yan
  • Christopher J Martyniuk
  • Chemosphere.2020 Mar;243:125416. S0045-6535(19)32656-6. doi: 10.1016/j.chemosphere.2019.125416.Epub 2019-11-22.

小児主観的全栄養評価では、体格差測定と比較して、より多くの脳性麻痺を持つ子どもが栄養不良と分類されている

The Pediatric Subjective Global Nutrition Assessment Classifies More Children With Cerebral Palsy as Malnourished Compared With Anthropometry.
  • Kristie L Bell
  • Katherine A Benfer
  • Robert S Ware
  • Tania A Patrao
  • Josephine J Garvey
  • Rachel Haddow
  • Roslyn N Boyd
  • Peter S W Davies
  • Joan C Arvedson
  • Kelly A Weir
  • J Acad Nutr Diet.2020 Jun;S2212-2672(20)30347-6. doi: 10.1016/j.jand.2020.04.012.Epub 2020-06-24.

ネオアジュバント化学療法を適応とした乳癌におけるベースラインF-FDG PET/CTで得られたボリュームベースの代謝変数の予測と予後の可能性

Predictive and prognostic potential of volume-based metabolic variables obtained by a baseline F-FDG PET/CT in breast cancer with neoadjuvant chemotherapy indication.
  • A M Garcia-Vicente
  • J Pérez-Beteta
  • M Amo-Salas
  • D Molina
  • G A Jimenez-Londoño
  • A M Soriano-Castrejón
  • F J Pena Pardo
  • A Martínez-González
  • Rev Esp Med Nucl Imagen Mol.2018 Mar - Apr;37(2):73-79. S2253-654X(17)30130-0. doi: 10.1016/j.remn.2017.09.002.Epub 2017-11-02.

ニトロイミダゾール部位を有するスルファニルおよびスルホニルエーテル化安息香酸誘導体の合成とリーシュマニア的評価（英文

Synthesis and leishmanicidal evaluation of sulfanyl- and sulfonyl-tethered functionalized benzoate derivatives featuring a nitroimidazole moiety.
  • Miguel Rodríguez
  • Joyce Gutiérrez
  • José Domínguez
  • Philippe A Peixoto
  • Alexis Fernández
  • Noris Rodríguez
  • Denis Deffieux
  • Luis Rojas
  • Stéphane Quideau
  • Laurent Pouységu
  • Jaime Charris
  • Arch. Pharm. (Weinheim).2020 May;353(5):e2000002. doi: 10.1002/ardp.202000002.Epub 2020-03-16.

糖尿病の微小環境は、糸球体内皮細胞にミトコンドリア酸化ストレスを引き起こし、ポッドサイトとの病理学的クロストークを引き起こす

The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes.
  • Gabriella A Casalena
  • Liping Yu
  • Roberto Gil
  • Samuel Rodriguez
  • Shantel Sosa
  • William Janssen
  • Evren U Azeloglu
  • Jeremy S Leventhal
  • Ilse S Daehn
  • Cell Commun. Signal.2020 Jul;18(1):105. 10.1186/s12964-020-00605-x. doi: 10.1186/s12964-020-00605-x.Epub 2020-07-08.

Gnathodiaphyseal dysplasiaは、Ano5遺伝子の変異を持つそれぞれのマウスモデルでは再現されていない

Gnathodiaphyseal dysplasia is not recapitulated in a respective mouse model carrying a mutation of the Ano5 gene.
  • Tim Rolvien
  • Osman Avci
  • Simon von Kroge
  • Till Koehne
  • Stefan Selbert
  • Stephan Sonntag
  • Doron Shmerling
  • Uwe Kornak
  • Ralf Oheim
  • Michael Amling
  • Thorsten Schinke
  • Timur Alexander Yorgan
  • Bone Rep.2020 Jun;12:100281. S2352-1872(20)30041-3. doi: 10.1016/j.bonr.2020.100281.Epub 2020-05-14.

また、転写因子 FOXM1 をサイレンシングすることで、ALDH2 の発現を制御することで、肝癌幹細胞の増殖、遊走、浸潤を抑制し、アポトーシスを誘導することが示された

Silencing transcription factor FOXM1 represses proliferation, migration, and invasion while inducing apoptosis of liver cancer stem cells by regulating the expression of ALDH2.
  • Lijian Chen
  • Meiyun Wu
  • Chunyi Ji
  • Miaoxian Yuan
  • Chaoyang Liu
  • Qiang Yin
  • IUBMB Life.2020 02;72(2):285-295. doi: 10.1002/iub.2166.Epub 2019-10-03.

高悪性度軟部肉腫の統合的解析に基づくパゾパニブに対する反応予測バイオマーカーの評価。レスポンダーと他の軟部肉腫患者からの腫瘍サンプルの解析

Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas.
  • Yoshiyuki Suehara
  • Shinji Kohsaka
  • Shigeo Yamaguchi
  • Takuo Hayashi
  • Taisei Kurihara
  • Kei Sano
  • Keita Sasa
  • Keisuke Akaike
  • Toshihide Ueno
  • Shinya Kojima
  • Masachika Ikegami
  • Sho Mizuno
  • Taketo Okubo
  • Youngji Kim
  • Kazuo Kaneko
  • Tsuyoshi Saito
  • Shunsuke Kato
  • Hiroyuki Mano
  • Clin. Orthop. Relat. Res..2020 Jun;doi: 10.1097/CORR.0000000000001322.Epub 2020-06-10.

急性中耳炎の子供の抗生物質消費量を減らすための麻酔・鎮痛薬点耳薬：CEDAR RCT

Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT.
  • Alastair D Hay
  • Harriet Downing
  • Nick A Francis
  • Grace J Young
  • Clare Clement
  • Sue D Harris
  • Aideen Ahern
  • Behnaz Schofield
  • Tammy E Thomas
  • Jeremy Horwood
  • Peter S Blair
  • William Hollingworth
  • Victoria Wilson
  • Chris Metcalfe
  • Peter Stoddart
  • Desmond Nunez
  • Mark D Lyttle
  • Paul Little
  • Michael V Moore
  • Health Technol Assess.2019 07;23(34):1-48. doi: 10.3310/hta23340.

Ficus carica L.およびPrunus spinosa L.の抽出物は、アントシアニン系の新規食品着色料として期待されています。製菓製品における徹底した研究

Ficus carica L. and Prunus spinosa L. extracts as new anthocyanin-based food colorants: A thorough study in confectionery products.
  • Emanueli Backes
  • Maria G Leichtweis
  • Carla Pereira
  • Marcio Carocho
  • João C M Barreira
  • Aziza Kamal Genena
  • Ilton José Baraldi
  • Maria Filomena Barreiro
  • Lillian Barros
  • Isabel C F R Ferreira
  • Food Chem.2020 Jul;333:127457. S0308-8146(20)31319-4. doi: 10.1016/j.foodchem.2020.127457.Epub 2020-07-03.

飼料用植物3種の種子硝酸同化とフェノール系抗酸化剤の刺激によるペントースリン酸経路と硝酸還元の評価

Evaluation of seed nitrate assimilation and stimulation of phenolic-linked antioxidant on pentose phosphate pathway and nitrate reduction in three feed-plant species.
  • Derong Lin
  • Yichen Huang
  • Jingjing Zhao
  • Zhijun Wu
  • Shuliang Liu
  • Wen Qin
  • Dingtao Wu
  • Hong Chen
  • Qing Zhang
  • BMC Plant Biol..2020 Jun;20(1):267. 10.1186/s12870-020-02453-w. doi: 10.1186/s12870-020-02453-w.Epub 2020-06-09.

リドカインは生体膜の表面電荷をより正にし、血液脳関門培養モデルの透過性を変化させる

Lidocaine turns the surface charge of biological membranes more positive and changes the permeability of blood-brain barrier culture models.
  • Ana R Santa-Maria
  • Fruzsina R Walter
  • Sándor Valkai
  • Ana Rita Brás
  • Mária Mészáros
  • András Kincses
  • Adrián Klepe
  • Diana Gaspar
  • Miguel A R B Castanho
  • László Zimányi
  • András Dér
  • Mária A Deli
  • Biochim Biophys Acta Biomembr.2019 09;1861(9):1579-1591. S0005-2736(19)30158-0. doi: 10.1016/j.bbamem.2019.07.008.Epub 2019-07-10.

ロングノンコーディングRNA HUMTのハイメチル化は、トリプルネガティブ乳癌において、FOXK1転写を活性化することを介してリンパ管形成と転移を促進することが明らかになった

Long non-coding RNA HUMT hypomethylation promotes lymphangiogenesis and metastasis via activating FOXK1 transcription in triple-negative breast cancer.
  • Shaoquan Zheng
  • Lu Yang
  • Yutian Zou
  • Jie-Ying Liang
  • Peng Liu
  • Guanfeng Gao
  • Anli Yang
  • Hailin Tang
  • Xiaoming Xie
  • J Hematol Oncol.2020 03;13(1):17. 10.1186/s13045-020-00852-y. doi: 10.1186/s13045-020-00852-y.Epub 2020-03-05.

尿管内視鏡ホルミウムレーザー結石破砕術と迷走神経興奮の感染危険因子と発生率の診断に関する解析をコンピュータ断層撮影画像情報健康技術の下で行った

Analysis on the diagnosis of infection risk factors and the incidence of ureteroscopy holmium laser lithotripsy and vagal excitation under computed tomography image information health technology.
  • Yuelong Zhang
  • Qi Zhang
  • Jia Lv
  • Dahong Zhang
  • Neurosci. Lett..2020 Jun;:135224. S0304-3940(20)30494-8. doi: 10.1016/j.neulet.2020.135224.Epub 2020-06-30.

非心臓手術を受けた非弁膜症性心房細動患者における抗凝固療法中断後の周術期転帰

Perioperative outcomes of interrupted anticoagulation in patients with non-valvular atrial fibrillation undergoing non-cardiac surgery.
  • Bo Eun Park
  • Myung Hwan Bae
  • Hyeon Jeong Kim
  • Yoon Jung Park
  • Hong Nyun Kim
  • Se Yong Jang
  • Jang Hoon Lee
  • Dong Heon Yang
  • Hun Sik Park
  • Yongkeun Cho
  • Shung Chull Chae
  • Yeungnam Univ J Med.2020 Jul;yujm.2020.00353. doi: 10.12701/yujm.2020.00353.Epub 2020-07-16.

循環中のプレゲノム HBV RNA は、Nucleos(t)ide アナログ療法を受けている慢性 B 型肝炎患者において、一次的に完全長である

Circulating Pregenomic HBV RNA is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy.
  • Mark Anderson
  • Jeffery Gersch
  • Ka-Cheung Luk
  • George Dawson
  • Ivana Carey
  • Kosh Agarwal
  • Pir Shah
  • Geoffrey Dusheiko
  • Daryl Lau
  • Gavin Cloherty
  • Clin. Infect. Dis..2020 Jul;ciaa1015. doi: 10.1093/cid/ciaa1015.Epub 2020-07-20.

最適化された加水分解手順とタンデム質量分析と結合した超高性能液体クロマトグラフィーを使用して、魚類および藻類油サプリメント中のオキシリピンの定量

Quantitation of oxylipins in fish and algae oil supplements using optimized hydrolysis procedures and ultra-high performance liquid chromatography coupled to tandem mass-spectrometry.
  • Shiva Emami
  • Zhichao Zhang
  • Ameer Y Taha
  • J. Agric. Food Chem..2020 Jul;doi: 10.1021/acs.jafc.0c02461.Epub 2020-07-20.

脂肪組織におけるアディポネクチン遺伝子発現の増加は、慢性腎臓病患者における血清脂肪酸プロファイルの異常と関連している可能性がある

Increased adiponectin gene expression in adipose tissue may be related to an abnormal serum fatty acid profile in patients with chronic kidney disease.
  • Justyna Korczyńska
  • Aleksandra Czumaj
  • Michał Chmielewski
  • Maciej Śledziński
  • Adriana Mika
  • Tomasz Śledziński
  • 2020 Jul;doi: 10.20452/pamw.15517.Epub 2020-07-20.

仮性脳腫瘍性症候群の小児患者におけるベッドサイド眼科超音波による視神経鞘径と網膜動脈抵抗率の測定

Optic Nerve Sheath Diameter and Retinal Artery Resistive Index Measurements with Bedside Ophthalmic Ultrasound in Pediatric Patients with Pseudotumor Cerebri Syndrome.
  • Nagehan Aslan
  • Dincer Yildizdas
  • Neslihan Ozcan
  • Ozden Ozgur Horoz
  • Gulen Gul Mert
  • Yasar Sertdemir
  • Sakir Altunbasak
  • J Pediatr Intensive Care.2020 Sep;9(3):181-187. 1900075. doi: 10.1055/s-0040-1705112.Epub 2020-03-06.

超分子溶媒とキラル液体クロマトグラフィー-タンデム質量分析法を組み合わせて、果物や野菜に含まれるペルメトリンの迅速かつ高感度なエナンチオ選択的定量を行う

Quick and sensitive enantioselective determination of permethrin in fruits and vegetables by combining supramolecular solvents and chiral liquid chromatography-tandem mass spectrometry.
  • Ana Belén Lara
  • Carmen Caballo
  • María Dolores Sicilia
  • Soledad Rubio
  • J. Agric. Food Chem..2020 Jul;doi: 10.1021/acs.jafc.0c02533.Epub 2020-07-20.

UV-LEDと塩素を併用することで、真菌胞子の不活化と光不活化を同時に高めることができます。キネティクスとメカニズム

Simultaneously enhance the inactivation and inhibit the photoreactivation of fungal spores by the combination of UV-LEDs and chlorine: Kinetics and mechanisms.
  • Qiqi Wan
  • Gang Wen
  • Ruihua Cao
  • Hui Zhao
  • Xiangqian Xu
  • Yuancheng Xia
  • Gehui Wu
  • Wei Lin
  • Jingyi Wang
  • Tinglin Huang
  • Water Res..2020 Jul;184:116143. S0043-1354(20)30680-1. doi: 10.1016/j.watres.2020.116143.Epub 2020-07-12.

第V因子ライデンとその後のアテローム血栓性イベントとの関連。個人参加者データのGENIUS-CHD研究

Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.
  • Bakhtawar K Mahmoodi
  • Vinicius Tragante
  • Marcus E Kleber
  • Michael V Holmes
  • Amand F Schmidt
  • Raymond O McCubrey
  • Laurence J Howe
  • Kenan Direk
  • Hooman Allayee
  • Ekaterina V Baranova
  • Peter S Braund
  • Graciela E Delgado
  • Niclas Eriksson
  • Crystel M Gijsberts
  • Yan Gong
  • Jaana Hartiala
  • Mahyar Heydarpour
  • Gerard Pasterkamp
  • Salma Kotti
  • Pekka Kuukasjärvi
  • Petra A Lenzini
  • Daniel Levin
  • Leo-Pekka Lyytikäinen
  • Jochen D Muehlschlegel
  • Christopher P Nelson
  • Kjell Nikus
  • Anna P Pilbrow
  • W H Wilson Tang
  • Sander W van der Laan
  • Jessica van Setten
  • Ragnar O Vilmundarson
  • John Deanfield
  • Panos Deloukas
  • Frank Dudbridge
  • Stefan James
  • Ify R Mordi
  • Andrej Teren
  • Thomas O Bergmeijer
  • Simon C Body
  • Michiel Bots
  • Ralph Burkhardt
  • Rhonda M Cooper-DeHoff
  • Sharon Cresci
  • Nicolas Danchin
  • Robert N Doughty
  • Diederick E Grobbee
  • Emil Hagström
  • Stanley L Hazen
  • Claes Held
  • Imo E Hoefer
  • G Kees Hovingh
  • Julie A Johnson
  • Marcin P Kaczor
  • Mika Kähönen
  • Olaf H Klungel
  • Jari O Laurikka
  • Terho Lehtimäki
  • Anke H Maitland-van der Zee
  • Ruth McPherson
  • Colin N Palmer
  • Adriaan O Kraaijeveld
  • Carl J Pepine
  • Marek Sanak
  • Naveed Sattar
  • Markus Scholz
  • Tabassome Simon
  • John A Spertus
  • Alexandre F R Stewart
  • Wojciech Szczeklik
  • Joachim Thiery
  • Frank L J Visseren
  • Johannes Waltenberger
  • A Mark Richards
  • Chim C Lang
  • Vicky A Cameron
  • Axel Åkerblom
  • Guillaume Pare
  • Winfried März
  • Nilesh J Samani
  • Aroon D Hingorani
  • Jurriën M Ten Berg
  • Lars Wallentin
  • Folkert W Asselbergs
  • Riyaz Patel
  • Circulation.2020 Jul;doi: 10.1161/CIRCULATIONAHA.119.045526.Epub 2020-07-13.

グリコシダーゼ触媒におけるエポキシド中間体

An Epoxide Intermediate in Glycosidase Catalysis.
  • Lukasz F Sobala
  • Gaetano Speciale
  • Sha Zhu
  • Lluís Raich
  • Natalia Sannikova
  • Andrew J Thompson
  • Zalihe Hakki
  • Dan Lu
  • Saeideh Shamsi Kazem Abadi
  • Andrew R Lewis
  • Víctor Rojas-Cervellera
  • Ganeko Bernardo-Seisdedos
  • Yongmin Zhang
  • Oscar Millet
  • Jesús Jiménez-Barbero
  • Andrew J Bennet
  • Matthieu Sollogoub
  • Carme Rovira
  • Gideon J Davies
  • Spencer J Williams
  • ACS Cent Sci.2020 May;6(5):760-770. doi: 10.1021/acscentsci.0c00111.Epub 2020-04-16.

アメントフラボンは、ヒト神経膠腫におけるオートファジー依存性フェロプトーシスを誘発することにより、細胞増殖を抑制し、細胞死を誘導します

Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma.
  • Yan Chen
  • Ning Li
  • Haijing Wang
  • Ningning Wang
  • Hui Peng
  • Jing Wang
  • Yihong Li
  • Mingdi Liu
  • Hui Li
  • Yu Zhang
  • Zhaohui Wang
  • Life Sci..2020 Apr;247:117425. S0024-3205(20)30172-7. doi: 10.1016/j.lfs.2020.117425.Epub 2020-02-11.

サイトカインシグナル伝達のサプレッサー（SOCS）1とSOCS3タンパク質は、マウスJ774マクロファージにおける炎症反応のインターロイキン-10調節のメディエーターであり、その主要な外膜タンパク質（MOMP）によって誘導された

Suppressors of Cytokine Signaling (SOCS)1 and SOCS3 Proteins Are Mediators of Interleukin-10 Modulation of Inflammatory Responses Induced by and Its Major Outer Membrane Protein (MOMP) in Mouse J774 Macrophages.
  • Skyla A Duncan
  • Rajnish Sahu
  • Saurabh Dixit
  • Shree R Singh
  • Vida A Dennis
  • Mediators Inflamm..2020;2020:7461742. doi: 10.1155/2020/7461742.Epub 2020-06-24.

マンゴージンジャー（curcuma amada）は、ラットの炎症性サイトカインレベルを調節することにより、コラーゲン誘発性関節炎を抑制する

Mango ginger (curcuma amada) inhibits collagen-induced arthritis by modulating inflammatory cytokine levels in rats.
  • Ahmet KarataŞ
  • Cemal Orhan
  • Mehmet Tuzcu
  • Nurhan Şahİn
  • İbrahİm Hanİfİ Özercan
  • SÜleyman Serdar Koca
  • Vijaya Juturu
  • Kazİm Şahİn
  • Turk J Med Sci.2020 Jul;doi: 10.3906/sag-2004-105.Epub 2020-07-14.

ソーシャルメディアへの曝露および相互作用が、PATH研究から、思春期の青少年におけるENDSおよびタバコ使用とどのように関連しているかを探る

Exploring how social media exposure and interactions are associated with ENDS and tobacco use in adolescents from the PATH study.
  • Patricia Cavazos-Rehg
  • Xiao Li
  • Erin Kasson
  • Nina Kaiser
  • Jacob T Borodovsky
  • Richard Grucza
  • Li-Shiun Chen
  • Laura J Bierut
  • Nicotine Tob. Res..2020 Jun;ntaa113. doi: 10.1093/ntr/ntaa113.Epub 2020-06-29.

1,2,3,3-トリアゾールとウルサンおよびルパンコアを連結した1,3,4-または1,2,5-オキサジアゾールの合成と細胞毒性

Synthesis and cytotoxicity of hybrids of 1,3,4- or 1,2,5-oxadiazoles tethered from ursane and lupane core with 1,2,3-triazole.
  • Sergey A Popov
  • Marya D Semenova
  • Dmitry S Baev
  • Tatiana S Frolova
  • Michael A Shestopalov
  • Chengzhang Wang
  • Zhiwen Qi
  • Elvira E Shults
  • Māris Turks
  • Steroids.2020 Jul;:108698. S0039-128X(20)30124-0. doi: 10.1016/j.steroids.2020.108698.Epub 2020-07-17.

ファブリー病の治療における酵素補充療法から経口シャペロンのミガラスタットへの切り替え：実際のデータ

Switch from enzyme replacement therapy to oral chaperone migalastat for treating fabry disease: real-life data.
  • Eleonora Riccio
  • Mario Zanfardino
  • Lucia Ferreri
  • Ciro Santoro
  • Sirio Cocozza
  • Ivana Capuano
  • Massimo Imbriaco
  • Sandro Feriozzi
  • Antonio Pisani
  • Eur. J. Hum. Genet..2020 Jul;10.1038/s41431-020-0677-x. doi: 10.1038/s41431-020-0677-x.Epub 2020-07-09.

デクスメデトミジン鎮静下の脆弱性X症候群の若年男性において、脳タンパク質合成の局所率は変化しない。L-1-Creucine PETによる研究

Regional rates of brain protein synthesis are unaltered in dexmedetomidine sedated young men with fragile X syndrome: A L-[1-C]leucine PET study.
  • Kathleen C Schmidt
  • Inna Loutaev
  • Zenaide Quezado
  • Carrie Sheeler
  • Carolyn Beebe Smith
  • Neurobiol. Dis..2020 Jun;143:104978. S0969-9961(20)30253-9. doi: 10.1016/j.nbd.2020.104978.Epub 2020-06-20.

EXOME REPORT：臨床診断でFragile X症候群が疑われ，CGGリピートの拡大を認めない患者におけるFMR1遺伝子の2つの新規遺伝子内変異

EXOME REPORT: Two novel intragenic variants in the FMR1 gene in patients with suspect clinical diagnosis of Fragile X syndrome and no CGG repeat expansion.
  • Renee Carroll
  • Marie Shaw
  • Maria Arvio
  • Alison Gardner
  • Raman Kumar
  • Bree Hodgson
  • Sarah Heron
  • Fiona McKenzie
  • Irma Järvelä
  • Jozef Gecz
  • Eur J Med Genet.2020 Jul;:104010. S1769-7212(19)30794-3. doi: 10.1016/j.ejmg.2020.104010.Epub 2020-07-17.

COVID-19の重症患者における静脈血栓塞栓症．深部静脈血栓症のスクリーニング試験の結果

Venous thromboembolism in critically Ill patients with COVID-19: Results of a screening study for deep vein thrombosis.
  • Alban Longchamp
  • Justine Longchamp
  • Sara Manzocchi-Besson
  • Livia Whiting
  • Claude Haller
  • Séverin Jeanneret
  • Manoelle Godio
  • Juan Jose Garcia Martinez
  • Thierry Bonjour
  • Mary Caillat
  • Guillaume Maitre
  • Julian Matthias Thaler
  • Rémy Pantet
  • Viviane Donner
  • Alexis Dumoulin
  • Stéphane Emonet
  • Gilbert Greub
  • Raymond Friolet
  • Helia Robert-Ebadi
  • Marc Righini
  • Bienvenido Sanchez
  • Julie Delaloye
  • Res Pract Thromb Haemost.2020 Jul;4(5):842-847. RTH212376. doi: 10.1002/rth2.12376.Epub 2020-06-30.

カドミウム硫化物ナノ粒子をベースとした新規コンジュゲートによる無細胞系で発現するヒトp53のin-vitro検出

Detection of Human p53 In-Vitro Expressed in a Transcription-Translation Cell-Free System by a Novel Conjugate Based on Cadmium Sulphide Nanoparticles.
  • Víctor Barba-Vicente
  • María Jesús Almendral Parra
  • Juan Francisco Boyero-Benito
  • Carlota Auría-Soro
  • Pablo Juanes-Velasco
  • Alicia Landeira-Viñuela
  • Álvaro Furones-Cuadrado
  • Ángela-Patricia Hernández
  • Raúl Manzano-Román
  • Manuel Fuentes
  • Nanomaterials (Basel).2020 May;10(5). E984. doi: 10.3390/nano10050984.Epub 2020-05-21.

ジンセノサイドRg3は、炎症を介したオートファジーシグナル伝達経路を減少させることで、肝線維症からの退行を促進します

Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway.
  • Xiangxiang Liu
  • Xiaojie Mi
  • Zi Wang
  • Ming Zhang
  • Jingang Hou
  • Shuang Jiang
  • Yingping Wang
  • Chen Chen
  • Wei Li
  • Cell Death Dis.2020 Jun;11(6):454. 10.1038/s41419-020-2597-7. doi: 10.1038/s41419-020-2597-7.Epub 2020-06-12.

アデフォビル・ジピボキシルの安定化された経口ナノ構造脂質担体の肝臓へのターゲッティングの可能性放射性ヨウ素化インジケーターの静脈内注射後の肝機能パネルおよび取り込み量の推定

Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator.
  • Shady M Abd El-Halim
  • Ghada A Abdelbary
  • Maha M Amin
  • Mohamed Y Zakaria
  • Hesham A Shamsel-Din
  • Ahmed B Ibrahim
  • Daru.2020 Jun;10.1007/s40199-020-00355-8. doi: 10.1007/s40199-020-00355-8.Epub 2020-06-20.

難治性ホジキンリンパ腫治療における重篤なアナフィラキシー後のブレンツキシマブ・ベドチンに対する迅速な脱感作

Rapid desensitization to brentuximab vedotin after severe anaphylaxis in the treatment of refractory Hodgkin's lymphoma.
  • Rosalaura V Villarreal-Gonzalez
  • Sandra N Gonzalez-Diaz
  • Cindy E de Lira-Quezada
  • David Gómez-Almaguer
  • Andres Gómez-De León
  • Natalhie Acuña-Ortega
  • J Oncol Pharm Pract.2020 Jul;:1078155220942292. doi: 10.1177/1078155220942292.Epub 2020-07-19.

日本人慢性腎臓病患者における貧血の有病率。日本慢性腎臓病データベース（J-CKD-DB）のデータを用いた全国横断的コホート研究

Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB).
  • Tadashi Sofue
  • Naoki Nakagawa
  • Eiichiro Kanda
  • Hajime Nagasu
  • Kunihiro Matsushita
  • Masaomi Nangaku
  • Shoichi Maruyama
  • Takashi Wada
  • Yoshio Terada
  • Kunihiro Yamagata
  • Ichiei Narita
  • Motoko Yanagita
  • Hitoshi Sugiyama
  • Takashi Shigematsu
  • Takafumi Ito
  • Kouichi Tamura
  • Yoshitaka Isaka
  • Hirokazu Okada
  • Kazuhiko Tsuruya
  • Hitoshi Yokoyama
  • Naoki Nakashima
  • Hiromi Kataoka
  • Kazuhiko Ohe
  • Mihoko Okada
  • Naoki Kashihara
  • PLoS ONE.2020;15(7):e0236132. PONE-D-20-14790. doi: 10.1371/journal.pone.0236132.Epub 2020-07-20.

ABCA1遺伝子R1587K多型は，メキシコ北部の成人において，メタボリックシンドロームや血漿中トリグリセリド濃度の上昇と関連している可能性があった．

ABCA1 gene R1587K polymorphism could be associated with metabolic syndrome and increased plasma triglyceride concentration in adults from northern Mexico.
  • Mildren Porchas Quijada
  • Zyanya Reyes Castillo
  • Oney Román Pellegrini
  • Elizabeth Artalejo Ochoa
  • Silvia Yolanda Moya Camarena
  • Maricela Montalvo Corral
  • Martha Nydia Ballesteros Vásquez
  • Nutr Hosp.2020 Jul;doi: 10.20960/nh.03087.Epub 2020-07-20.

ラット肝線維化モデルにおける超音波せん断波エラストグラフィのテスト-リテスト再現性：前臨床試験のための定量的バイオマーカーを目指して

Test-retest repeatability of ultrasonographic shear wave elastography in a rat liver fibrosis model: toward a quantitative biomarker for preclinical trials.
  • Youngbin Shin
  • Jimi Huh
  • Su Jung Ham
  • Young Chul Cho
  • Yoonseok Choi
  • Dong-Cheol Woo
  • Jeongjin Lee
  • Kyung Won Kim
  • Ultrasonography.2020 Apr;usg.19088. doi: 10.14366/usg.19088.Epub 2020-04-23.

脳内皮細胞は乳酸の恒常性を維持し、成人海馬の神経新生を制御している

Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis.
  • Jun Wang
  • Yaxiong Cui
  • Zhenyang Yu
  • Wenjing Wang
  • Xuan Cheng
  • Wenliang Ji
  • Shuyue Guo
  • Qing Zhou
  • Ning Wu
  • Yan Chen
  • Ying Chen
  • Xiaopeng Song
  • Hui Jiang
  • Yanxiao Wang
  • Yu Lan
  • Bin Zhou
  • Lanqun Mao
  • Jin Li
  • Huanming Yang
  • Weixiang Guo
  • Xiao Yang
  • Cell Stem Cell.2019 Dec;25(6):754-767.e9. S1934-5909(19)30420-5. doi: 10.1016/j.stem.2019.09.009.Epub 2019-11-21.

メチル化パノラマ表示が可能なカーボンドット修飾液状剥離グラフェン電界効果トランジスタを用いた臨床メチル化マルチプローブアッセイ

Multiprobe Assay for Clinical Methylation Based on the Carbon Dot-Modified Liquid-Exfoliated Graphene Field Effect Transistor with a Potential to Present a Methylation Panorama.
  • Dong Dong
  • Jizhao Zhang
  • Runshi Zhang
  • Fang Li
  • Yueguo Li
  • Yunfang Jia
  • ACS Omega.2020 Jul;5(26):16228-16237. doi: 10.1021/acsomega.0c02022.Epub 2020-06-25.

ベバシズマブとトリフルリジン/チミジンホスホリラーゼ阻害剤を併用することで、転移性大腸がん患者のフロントライン治療におけるベバシズマブの使用歴にかかわらず、生存率が向上します

Combining Bevacizumab With Trifluridine/Thymidine Phosphorylase Inhibitor Improves the Survival Outcomes Regardless of the Usage History of Bevacizumab in Front-line Treatment of Patients With Metastatic Colorectal Cancer.
  • Masatsune Shibutani
  • Hisashi Nagahara
  • Tatsunari Fukuoka
  • Yasuhito Iseki
  • E N Wang
  • Yuki Okazaki
  • Shinichiro Kashiwagi
  • Kiyoshi Maeda
  • Kosei Hirakawa
  • Masaichi Ohira
  • Anticancer Res..2020 Jul;40(7):4157-4163. 40/7/4157. doi: 10.21873/anticanres.14415.

2型糖尿病を併発する心不全患者におけるナトリウム-グルコースコトランスポーター2阻害薬の短期的なナトリウム利尿作用の機序と予測

Mechanisms and prediction of short-term natriuretic effect of sodium-glucose cotransporter 2 inhibitor in heart failure patients coexisting type 2 diabetes mellitus.
  • Shusuke Fukuoka
  • Kaoru Dohi
  • Tetsushiro Takeuchi
  • Keishi Moriwaki
  • Masaki Ishiyama
  • Taku Omori
  • Naoki Fujimoto
  • Masaaki Ito
  • Heart Vessels.2020 Apr;10.1007/s00380-020-01597-x. doi: 10.1007/s00380-020-01597-x.Epub 2020-04-08.

英国のプライマリーケアに通院する大腸がんの症状を持つ成人患者を対象とした糞便免疫化学検査：14487件の連続検査依頼を対象としたレトロスペクティブコホート研究

Faecal immunochemical testing for adults with symptoms of colorectal cancer attending English primary care: a retrospective cohort study of 14 487 consecutive test requests.
  • Brian D Nicholson
  • Tim James
  • Maria Paddon
  • Steve Justice
  • Jason L Oke
  • James E East
  • Brian Shine
  • Aliment. Pharmacol. Ther..2020 Jul;doi: 10.1111/apt.15969.Epub 2020-07-17.

馬の排卵前卵胞液のメタボロミクスの研究。現在の体外成熟媒体を改善する方法

Study of the Metabolomics of Equine Preovulatory Follicular Fluid: A Way to Improve Current In Vitro Maturation Media.
  • Pablo Fernández-Hernández
  • María Jesús Sánchez-Calabuig
  • Luis Jesús García-Marín
  • María J Bragado
  • Alfonso Gutiérrez-Adán
  • Óscar Millet
  • Chiara Bruzzone
  • Lauro González-Fernández
  • Beatriz Macías-García
  • Animals (Basel).2020 May;10(5). E883. doi: 10.3390/ani10050883.Epub 2020-05-19.

A Rare Case of Grade 1 Endometrioid Adenocarcinoma of the Uterus With Omental Metastasis with Brenner Tumor of the Ovary in a Postmenausal Female

A Rare Case of Grade 1 Endometrioid Adenocarcinoma of the Uterus With Omental Metastasis with Brenner Tumor of the Ovary in a Postmenopausal Female.
  • Rashmi Bagga
  • Rubina Pandit
  • Pradip Kumar Saha
  • Jasvinder Kalra
  • Tanuja Muthyala
  • Nalini Gupta
  • Tulika Singh
  • Bhavna Rai
  • J Midlife Health.2020 Jan-Mar;11(1):45-48. JMH-11-45. doi: 10.4103/jmh.JMH_141_18.Epub 2020-05-04.

サーチュイン 3 介在性アシル-CoA 合成酵素ファミリーメンバー 3 のプロトカテキン酸による脱アセチル化は非アルコール性脂肪肝疾患を抑制する

Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates nonalcoholic fatty liver disease.
  • Ruimin Sun
  • Xiaohui Kang
  • Yan Zhao
  • Zhanyu Wang
  • Ruiwen Wang
  • Rong Fu
  • Yang Li
  • Yan Hu
  • Zhecheng Wang
  • Wen Shan
  • Junjun Zhou
  • Xiaofeng Tian
  • Jihong Yao
  • Br. J. Pharmacol..2020 Jun;doi: 10.1111/bph.15159.Epub 2020-06-10.

交差給餌は、大腸菌とサルモネラ菌のモデル微生物群集における抗生物質耐性進化の速度とメカニズムを調節することを明らかにした

Cross-feeding modulates the rate and mechanism of antibiotic resistance evolution in a model microbial community of Escherichia coli and Salmonella enterica.
  • Elizabeth M Adamowicz
  • Michaela Muza
  • Jeremy M Chacón
  • William R Harcombe
  • PLoS Pathog..2020 Jul;16(7):e1008700. PPATHOGENS-D-20-00442. doi: 10.1371/journal.ppat.1008700.Epub 2020-07-20.

薬理学的課題：成人ロングエバンスラットにおける概日リズムの乱れによる反応抑制と注意力の変化の根底にあるメカニズムを検討している

Pharmacological challenges examining the underlying mechanism of altered response inhibition and attention due to circadian disruption in adult Long-Evans rats.
  • Rekha C Balachandran
  • Katherine M Hatcher
  • Megan L Sieg
  • Emma K Sullivan
  • Leonardo M Molina
  • Megan M Mahoney
  • Paul A Eubig
  • Pharmacol. Biochem. Behav..2020 06;193:172915. S0091-3057(19)30549-0. doi: 10.1016/j.pbb.2020.172915.Epub 2020-03-26.

左室駆出率が保存されている安定した冠動脈疾患が知られている、または疑われる患者における核医学的な心臓病学的検査で評価された左室同期不全の予後評価の価値

Prognostic Value of Left Ventricular Dyssynchrony Assessed with Nuclear Cardiology in Patients with Known or Suspected Stable Coronary Artery Disease with Preserved Left Ventricular Ejection Fraction.
  • Takumi Hatta
  • Shunichi Yoda
  • Misa Hayase
  • Koyuru Monno
  • Yusuke Hori
  • Hidesato Fujito
  • Yasuyuki Suzuki
  • Naoya Matsumoto
  • Yasuo Okumura
  • Int Heart J.2020 Jul;doi: 10.1536/ihj.20-008.Epub 2020-07-18.

ACL再建後の持続性ハムストリング欠損症患者における標的運動の膝筋機能への影響-無作為化比較試験プロトコールの検討

The effect of targeted exercise on knee-muscle function in patients with persistent hamstring deficiency following ACL reconstruction - study protocol for a randomized controlled trial.
  • Bo Bregenhof
  • Uffe Jørgensen
  • Per Aagaard
  • Nis Nissen
  • Mark W Creaby
  • Jonas Bloch Thorlund
  • Carsten Jensen
  • Trine Torfing
  • Anders Holsgaard-Larsen
  • Trials.2018 Jan;19(1):75. 10.1186/s13063-018-2448-3. doi: 10.1186/s13063-018-2448-3.Epub 2018-01-26.

mtDNAを生体内で操作することで、新規応答機構を介して代謝を再プログラムする

Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms.
  • Diana Bahhir
  • Cagri Yalgin
  • Liina Ots
  • Sampsa Järvinen
  • Jack George
  • Alba Naudí
  • Tatjana Krama
  • Indrikis Krams
  • Mairi Tamm
  • Ana Andjelković
  • Eric Dufour
  • Jose M González de Cózar
  • Mike Gerards
  • Mikael Parhiala
  • Reinald Pamplona
  • Howard T Jacobs
  • Priit Jõers
  • PLoS Genet..2019 10;15(10):e1008410. PGENETICS-D-19-00109. doi: 10.1371/journal.pgen.1008410.Epub 2019-10-04.

量子ドット-メロペネム結合体をナノツールとして用いたバイオフィルム形成および抗菌抵抗性に対するカルボニルシアン-3-クロロフェニルヒドラゾンの活性

Activity of carbonyl cyanide-3-chlorophenylhydrazone on biofilm formation and antimicrobial resistance inusing quantum dots-meropenem conjugates as nanotools.
  • Valdemir Vicente Silva JÚnior
  • Bruno Raposo
  • Ana Catarina S Lopes
  • Paulo S R Araújo
  • Adriana Fontes
  • Paulo Euzebio Cabral Filho
  • Maria Amélia V Maciel
  • Methods Appl Fluoresc.2020 Jul;doi: 10.1088/2050-6120/aba7a2.Epub 2020-07-20.

バルーン肺血管形成術後のCTEPH患者における運動に対する血行動態反応に対するリオシグアトの有益な効果 - 無作為化比較試験

Beneficial effects of riociguat on hemodynamic responses to exercise in CTEPH patients after balloon pulmonary angioplasty - A randomized controlled study.
  • Tatsuo Aoki
  • Koichiro Sugimura
  • Yosuke Terui
  • Shunsuke Tatebe
  • Shigefumi Fukui
  • Masanobu Miura
  • Saori Yamamoto
  • Nobuhiro Yaoita
  • Hideaki Suzuki
  • Haruka Sato
  • Katsuya Kozu
  • Ryo Konno
  • Satoshi Miyata
  • Kotaro Nochioka
  • Kimio Satoh
  • Hiroaki Shimokawa
  • Int J Cardiol Heart Vasc.2020 Aug;29:100579. S2352-9067(20)30277-3. doi: 10.1016/j.ijcha.2020.100579.Epub 2020-07-10.

原発性中枢神経系リンパ腫における中枢神経系抗原に対する多反応性を高める体細胞性超変異の過程

The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma.
  • Manuel Montesinos-Rongen
  • Monica Terrao
  • Caroline May
  • Katrin Marcus
  • Ingmar Blümcke
  • Martin Hellmich
  • Ralf Küppers
  • Anna Brunn
  • Martina Deckert
  • Haematologica.2020 Mar;haematol.2019.242701. doi: 10.3324/haematol.2019.242701.Epub 2020-03-19.

ステージ0の急性シャルコー神経関節症における臨床的特徴、放射線学的特徴、およびオフロードの方法 - 南インドの単一施設での経験

Clinical features, radiological characteristics and offloading modalities in stage 0 Acute Charcot's neuroarthropathy - A single centre experience from South India.
  • Anjely P Sebastian
  • Riddhi Dasgupta
  • Felix Jebasingh
  • Bharathi Saravanan
  • Bobeena Chandy
  • Koyeli Mary Mahata
  • Dukhabandhu Naik
  • Thomas Paul
  • Nihal Thomas
  • Diabetes Metab Syndr.2019 Mar - Apr;13(2):1081-1085. S1871-4021(18)30610-6. doi: 10.1016/j.dsx.2019.01.008.Epub 2019-01-22.

心原性ショックを呈した複雑な先天性小児患者に対する経皮的大動脈弁置換術へのSuprasternal approach to transcatheter aortic valve replacement in the complex congenital pediatric patients presented with cardiogenic shock

Suprasternal approach to transcatheter aortic valve replacement in a complex congenital pediatric patient presenting with cardiogenic shock.
  • Jacob Elrod
  • Shane Prejean
  • Hussein Abu Daya
  • Thomas Watts
  • Jared Kato
  • Ashley Reed
  • Robb L Romp
  • Gregory Von Mering
  • Kyle Eudailey
  • Mark A Law
  • Mustafa Ahmed
  • Cardiovasc Revasc Med.2020 Apr;S1553-8389(20)30238-4. doi: 10.1016/j.carrev.2020.04.032.Epub 2020-04-29.

レトロシグモイド開頭術中のフレームレス・ニューロナビゲーションのための3Dプリントされた特注マスクモデル。前臨床試験では、死体を用いたフィージビリティスタディを実施した

A 3D printed custom-made mask model for frameless neuronavigation during retrosigmoid craniotomy. A preclinical cadaveric feasibility study.
  • Pietro Canzi
  • Irene Avato
  • Stefania Marconi
  • Mattia Del Maestro
  • Alice Giotta Lucifero
  • Marianna Magnetto
  • Elena Carlotto
  • Ferdinando Auricchio
  • Sabino Luzzi
  • Marco Benazzo
  • Ann Ital Chir.2020 Jun;9. S2239253X20032843. Epub 2020-06-16.

ヒトDNAグリコシラーゼNTHL1のN末端ドメインにおける生殖細胞変異体の発現は、酵素機能や基質特異性を損なうことなく細胞形質転換を誘導する

Expression of a germline variant in the N-terminal domain of the human DNA glycosylase NTHL1 induces cellular transformation without impairing enzymatic function or substrate specificity.
  • Carolyn G Marsden
  • Pawel Jaruga
  • Erdem Coskun
  • Robyn L Maher
  • David S Pederson
  • Miral Dizdaroglu
  • Joann B Sweasy
  • Oncotarget.2020 Jun;11(24):2262-2272. 27548. doi: 10.18632/oncotarget.27548.Epub 2020-06-16.

TPLATEのリクルートは、植生菌根相互作用における共生界面の集合体における細胞内動態を明らかにした

TPLATE Recruitment Reveals Endocytic Dynamics at Sites of Symbiotic Interface Assembly in Arbuscular Mycorrhizal Interactions.
  • Giulia Russo
  • Gennaro Carotenuto
  • Valentina Fiorilli
  • Veronica Volpe
  • Antonella Faccio
  • Paola Bonfante
  • Mireille Chabaud
  • Marco Chiapello
  • Daniel Van Damme
  • Andrea Genre
  • Front Plant Sci.2019;10:1628. doi: 10.3389/fpls.2019.01628.Epub 2019-12-20.

難聴または重度の難聴を有する神経線維腫症2の患者における回復力の育成：ライブビデオ無作為化対照試験

Cultivating resiliency in patients with neurofibromatosis 2 who are deafened or have severe hearing loss: a live‑video randomized control trial.
  • Jonathan Greenberg
  • Sarah Carter
  • Ethan Lester
  • Christopher J Funes
  • Eric A Macklin
  • Scott Plotkin
  • Ana-Maria Vranceanu
  • J. Neurooncol..2019 Dec;145(3):561-569. 10.1007/s11060-019-03326-5. doi: 10.1007/s11060-019-03326-5.Epub 2019-11-01.

TinMan試験：心理学的情報に基づいた、聴覚士による、耳鳴りに対する手動化された介入の実現可能性試験

The TinMan study: feasibility trial of a psychologically informed, audiologist-delivered, manualised intervention for tinnitus.
  • John A Taylor
  • Dean M Thompson
  • Deborah A Hall
  • Dawn-Marie Walker
  • Mary McMurran
  • Amanda Casey
  • Debbie Featherstone
  • Carol MacDonald
  • David Stockdale
  • Derek J Hoare
  • Int J Audiol.2020 Jul;:1-10. doi: 10.1080/14992027.2020.1788730.Epub 2020-07-17.

レズビアン、ゲイ、バイセクシャル、トランスジェンダーの人々のためのプライマリ・ケアの変革（Transforming Primary Care for Lesbian, Gay, Bisexual, and Transgender）。A Collaborative Quality Improvement Initiative

Transforming Primary Care for Lesbian, Gay, Bisexual, and Transgender People: A Collaborative Quality Improvement Initiative.
  • Bruce W Furness
  • Hilary Goldhammer
  • Wanda Montalvo
  • Kelly Gagnon
  • Lauren Bifulco
  • Daniel Lentine
  • Daren Anderson
  • Ann Fam Med.2020 Jul;18(4):292-302. 18/4/292. doi: 10.1370/afm.2542.

レトロシグモイド開頭術中のフレームレスニューロナビゲーションのための3Dプリントされたカスタムメイドマスクモデル。前臨床段階での死体実験の実現可能性の研究

A 3D printed custom-made mask model for frameless neuronavigation during retrosigmoid craniotomy. A preclinical cadaveric feasibility study.
  • Pietro Canzi
  • Irene Avato
  • Stefania Marconi
  • Mattia Del Maestro
  • Alice Giotta Lucifero
  • Marianna Magnetto
  • Elena Carlotto
  • Ferdinando Auricchio
  • Sabino Luzzi
  • Marco Benazzo
  • Ann Ital Chir.2020 Jun;9. S0003469X20032844. Epub 2020-06-16.

ポリメチルメタクリレートセメントの代替としての強靭で注射可能な繊維強化リン酸カルシウムセメント：バイオメカニクス研究

Tough and injectable fiber reinforced calcium phosphate cement as an alternative to polymethylmethacrylate cement for vertebral augmentation: a biomechanical study.
  • Sónia de Lacerda Schickert
  • João Castro Pinto
  • John Jansen
  • Sander C G Leeuwenburgh
  • Jeroen J J P van den Beucken
  • Biomater Sci.2020 Jun;doi: 10.1039/d0bm00413h.Epub 2020-06-24.

HIV感染者における多様な結核菌株に対するRD-1特異的IFN-γ宿主応答の違いは、ESX-1領域における遺伝子型の違いによって説明できるかもしれない

Differential RD-1-specific IFN-γ host responses to diverse Mycobacterium tuberculosis strains in HIV-uninfected persons may be explained by genotypic variation in the ESX-1 region.
  • Michele Tomasicchio
  • Jason Limberis
  • Ruben van der Merwe
  • Rachael Jacobson
  • Richard Meldau
  • Grant Theron
  • Mark Nicol
  • Rob Warren
  • Keertan Dheda
  • Int. J. Infect. Dis..2020 Jul;96:240-243. S1201-9712(20)30268-X. doi: 10.1016/j.ijid.2020.04.053.Epub 2020-04-24.

慢性肉芽腫性疾患を合併した歯の自己抜歯後に下顎粘膜真菌症を発症した1例。症例報告と文献レビュー

Case of mucormycosis of mandible after self-extraction of teeth incidentally detected to have chronic granulomatous disease: Case report and literature review.
  • Shubham Agarwal
  • Abhishek Anand
  • Piyush Ranjan
  • Ved Prakash Meena
  • Animesh Ray
  • Rimlee Dutta
  • Ranveer Singh Jadon
  • Naval Kishore Vikram
  • Med Mycol Case Rep.2020 Jun;28:55-59. S2211-7539(20)30019-1. doi: 10.1016/j.mmcr.2020.03.005.Epub 2020-04-11.

アルゼンチン中央部のカンジダ症患者から分離されたカンジダ・パラプシローシス種複合体の頻度，病原性因子および抗真菌感受性．

Frequency, virulence factors and antifungal susceptibility of Candida parapsilosis species complex isolated from patients with candidemia in the central region of Argentina.
  • C Vigezzi
  • P A Icely
  • C Dudiuk
  • E Rodríguez
  • M S Miró
  • G D V Castillo
  • A I Azcurra
  • C Abiega
  • J P Caeiro
  • F O Riera
  • G García-Effrón
  • C E Sotomayor
  • J Mycol Med.2019 Dec;29(4):285-291. S1156-5233(19)30120-9. doi: 10.1016/j.mycmed.2019.100907.Epub 2019-10-15.

ベルギーの精神科医の、精神疾患を持つ成人患者に対する安楽死の評価手順に対する態度と、安楽死の評価手順に関与する準備ができているか：調査

Belgian psychiatrists' attitudes towards, and readiness to engage in, euthanasia assessment procedures with adults with psychiatric conditions: a survey.
  • Monica Verhofstadt
  • Kurt Audenaert
  • Kris Van den Broeck
  • Luc Deliens
  • Freddy Mortier
  • Koen Titeca
  • Koen Pardon
  • Kenneth Chambaere
  • BMC Psychiatry.2020 Jul;20(1):374. 10.1186/s12888-020-02775-x. doi: 10.1186/s12888-020-02775-x.Epub 2020-07-16.

ランダムサバイバルフォレストを用いた息止めCT画像を用いた肺定位体放射線治療の予後予測へのラジオミクスアプローチの適用と限界．多施設共同研究

Application and limitation of radiomics approach to prognostic prediction for lung stereotactic body radiotherapy using breath-hold CT images with random survival forest: A multi-institutional study.
  • Ryo Kakino
  • Mitsuhiro Nakamura
  • Takamasa Mitsuyoshi
  • Takashi Shintani
  • Masaki Kokubo
  • Yoshiharu Negoro
  • Masato Fushiki
  • Masakazu Ogura
  • Satoshi Itasaka
  • Chikako Yamauchi
  • Shuji Otsu
  • Takashi Sakamoto
  • Masato Sakamoto
  • Norio Araki
  • Hideaki Hirashima
  • Takanori Adachi
  • Yukinori Matsuo
  • Takashi Mizowaki
  • Med Phys.2020 Jul;doi: 10.1002/mp.14380.Epub 2020-07-09.

腰椎椎間板mRNAシークエンシングにより、椎間板ヘルニアと脊椎関節症の患者における制御経路を明らかにしました

Lumbar intervertebral disc mRNA sequencing identifies the regulatory pathway in patients with disc herniation and spondylolisthesis.
  • Mohamad Bydon
  • F M Moinuddin
  • Yagiz U Yolcu
  • Waseem Wahood
  • Mohammed Ali Alvi
  • Anshit Goyal
  • Mohammed Elminawy
  • Catalina Galeano-Garces
  • Amel Dudakovic
  • Ahmad Nassr
  • A Noelle Larson
  • Andre J van Wijnen
  • Gene.2020 Aug;750:144634. S0378-1119(20)30303-6. doi: 10.1016/j.gene.2020.144634.Epub 2020-03-30.

マイクロハイブリッドおよびナノ充填樹脂複合材料の表面特性に及ぼす歯磨きの影響を、異なる仕上げおよび研磨手順に従った場合に示した

Effects of toothbrushing on surface characteristics of microhybrid and nanofilled resin composites following different finishing and polishing procedures.
  • Alaa Daud
  • Alexander J Adams
  • Athra Shawkat
  • Gordon Gray
  • Nairn H F Wilson
  • Christopher D Lynch
  • Igor R Blum
  • J Dent.2020 May;:103376. S0300-5712(20)30122-6. doi: 10.1016/j.jdent.2020.103376.Epub 2020-05-26.

SCAPERの欠失は、減数分裂時の微小管ダイナミクスを調節することにより、ヒトでは男性不妊を引き起こす

Absence of SCAPER causes male infertility in humans and by modulating microtubule dynamics during meiosis.
  • Ohad Wormser
  • Ygal Levy
  • Anna Bakhrat
  • Silvia Bonaccorsi
  • Lucia Graziadio
  • Maurizio Gatti
  • Ali AbuMadigham
  • Richard J McKenney
  • Kyoko Okada
  • Saad El Riati
  • Iris Har-Vardi
  • Mahmoud Huleihel
  • Eliahu Levitas
  • Ohad S Birk
  • Uri Abdu
  • J. Med. Genet..2020 Jun;jmedgenet-2020-106946. doi: 10.1136/jmedgenet-2020-106946.Epub 2020-06-11.

前立腺癌における IL-17A、IL-17F、IL-17RA、および IL-17RC の発現レベルとグリソンスケールによる組織学的グレードを考慮した良性前立腺肥大症との比較：新たな治療法の選択肢を求めて

Expression Levels of IL-17A, IL-17F, IL-17RA, and IL-17RC in Prostate Cancer with Taking into Account the Histological Grade according to Gleason Scale in Comparison to Benign Prostatic Hyperplasia: In Search of New Therapeutic Options.
  • Marlena Janiczek
  • Łukasz Szylberg
  • Paulina Antosik
  • Anna Kasperska
  • Andrzej Marszałek
  • J Immunol Res.2020;2020:4910595. doi: 10.1155/2020/4910595.Epub 2020-05-25.

インピーダンスバイオセンサーと免疫磁気分離を組み合わせることで、家禽サプライチェーンにおけるサルモネラ菌の迅速なスクリーニングが可能となる

Combining impedance biosensor with immunomagnetic separation for rapid screening of Salmonella in poultry supply chains.
  • Lei Wang
  • Li Xue
  • Ruya Guo
  • Lingyan Zheng
  • Siyuan Wang
  • Lan Yao
  • Xiaoting Huo
  • Ning Liu
  • Ming Liao
  • Yanbin Li
  • Jianhan Lin
  • Poult. Sci..2020 Mar;99(3):1606-1614. S0032-5791(19)57918-4. doi: 10.1016/j.psj.2019.12.007.Epub 2020-01-24.

重症患者における微量栄養素、リン酸塩およびマグネシウムのモニタリングおよび非経口投与。VITA-TRACE調査

Monitoring and parenteral administration of micronutrients, phosphate and magnesium in critically ill patients: The VITA-TRACE survey.
  • Wouter Vankrunkelsven
  • Jan Gunst
  • Karin Amrein
  • Danielle E Bear
  • Mette M Berger
  • Kenneth B Christopher
  • Valentin Fuhrmann
  • Michael Hiesmayr
  • Carole Ichai
  • Stephan M Jakob
  • Sigismond Lasocki
  • Juan C Montejo
  • Heleen M Oudemans-van Straeten
  • Jean-Charles Preiser
  • Annika Reintam Blaser
  • Anne-Françoise Rousseau
  • Pierre Singer
  • Joel Starkopf
  • Arthur R van Zanten
  • Steffen Weber-Carstens
  • Jan Wernerman
  • Alexander Wilmer
  • Michael P Casaer
  • Clin Nutr.2020 Jun;S0261-5614(20)30295-8. doi: 10.1016/j.clnu.2020.06.005.Epub 2020-06-14.

NTRK融合遺伝子を持つ患者における精密医療とその実施：発展途上国からの視点

Precision medicine and its implementation in patients with NTRK fusion genes: perspective from developing countries.
  • Andrés F Cardona
  • Oscar Arrieta
  • Alejandro Ruiz-Patiño
  • Carolina Sotelo
  • Nataly Zamudio-Molano
  • Zyanya Lucia Zatarain-Barrón
  • Luisa Ricaurte
  • Luis Raez
  • Marco Polo Peralta Álvarez
  • Feliciano Barrón
  • Leonardo Rojas
  • Christian Rolfo
  • Niki Karachaliou
  • Miguel Angel Molina-Vila
  • Rafael Rosell
  • Ther Adv Respir Dis.2020 Jan-Dec;14:1753466620938553. doi: 10.1177/1753466620938553.

ケニアの沿岸地域に通う思春期の女子生徒の教育的および心理社会的コンピテンシーにおける学年内変動：学校に基づく介入の意味合い

Intra-grade variability in educational and psychosocial competencies of school going adolescent girls, in the coastal region of Kenya: implications for school based interventions.
  • Beth Kangwana
  • Eunice Muthengi
  • Karen Austrian
  • BMC Public Health.2020 Jul;20(1):1097. 10.1186/s12889-020-09097-3. doi: 10.1186/s12889-020-09097-3.Epub 2020-07-13.

性病、その他の性器感染症の予防と避妊の両方を提供する膣剤の開発に関する研究。3.カンジダ・アルビカンスおよびトリコモナス膣炎の膣避妊薬および選択された膣製剤のin vitro効果

Studies on development of a vaginal preparation providing both prophylaxis against venereal disease, other genital infections and contraception. 3. In vitro effect of vaginal contraceptive and selected vaginal preparations of Candida albicans and Trichomonas vaginalis.
  • B Singh
  • J C Cutler
  • H M Utidjian
  • Contraception.1972 May;5(5):401-11. 0010-7824(72)90032-7. doi: 10.1016/0010-7824(72)90032-7.

先天性ジカ症候群の小児の口腔および顎顔面の状態、食事面、栄養状態

Oral and maxillofacial conditions, dietary aspects, and nutritional status of children with congenital Zika syndrome.
  • Ana Márcia Menezes de Oliveira
  • Elisama Gomes Magalhães de Melo
  • Mário Luis Tavares Mendes
  • Sheila Jaqueline Gomes Dos Santos Oliveira
  • Carolina Santos Souza Tavares
  • Andreia Centenaro Vaez
  • Sara Juliana Abreu de Vasconcelos
  • Hudson P Santos
  • Victor Santana Santos
  • Paulo Ricardo Saquete Martins-Filho
  • Oral Surg Oral Med Oral Pathol Oral Radiol.2020 Jul;130(1):71-77. S2212-4403(20)30069-9. doi: 10.1016/j.oooo.2020.02.019.Epub 2020-05-31.

SARS-CoV-2のサンプル不活化、増幅、およびCas13ベースの検出を統合

Integrated sample inactivation, amplification, and Cas13-based detection of SARS-CoV-2.
  • Jon Arizti-Sanz
  • Catherine A Freije
  • Alexandra C Stanton
  • Chloe K Boehm
  • Brittany A Petros
  • Sameed Siddiqui
  • Bennett M Shaw
  • Gordon Adams
  • Tinna-Solveig F Kosoko-Thoroddsen
  • Molly E Kemball
  • Robin Gross
  • Loni Wronka
  • Katie Caviness
  • Lisa E Hensley
  • Nicholas H Bergman
  • Bronwyn L MacInnis
  • Jacob E Lemieux
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  • Cameron Myhrvold
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モノテルペンであるイソプレゴールとそのβ-シクロデキストリン（β-CD）包接体の動物炎症モデルにおける抗催吐性および抗炎症活性

Antiedematogenic and Anti-Inflammatory Activity of the Monoterpene Isopulegol and Its β-Cyclodextrin (β-CD) Inclusion Complex in Animal Inflammation Models.
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ユビキチン特異的プロテアーゼ53のノックダウンは、DNA損傷結合タンパク質2を制御することで、ヒト子宮頸部扁平上皮癌の放射線感受性を向上させる

Knockdown of Ubiquitin-Specific Protease 53 Enhances the Radiosensitivity of Human Cervical Squamous Cell Carcinoma by Regulating DNA Damage-Binding Protein 2.
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中国人集団における頸動脈内膜切除術とステント留置術。頭蓋外頸動脈狭窄症の再灌流試験の安全性成績

Carotid Endarterectomy and Stenting in a Chinese Population: Safety Outcome of the Revascularization of Extracranial Carotid Artery Stenosis Trial.
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虫歯性歯髄露出のある成熟歯における歯髄切除または根管治療後の歯内療法後の疼痛。多施設共同無作為化比較試験

Postendodontic Pain after Pulpotomy or Root Canal Treatment in Mature Teeth with Carious Pulp Exposure: A Multicenter Randomized Controlled Trial.
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エドキサバン北斎VTE PEDIATRICS試験。小児静脈血栓塞栓症に対するエドキサバンの非盲検多施設無作為化試験

The Edoxaban Hokusai VTE PEDIATRICS Study: An open-label, multicenter, randomized study of edoxaban for pediatric venous thromboembolic disease.
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糖尿病性足疾患の予防と管理のための集学的アプローチに関するガイドライン（2020年版）

Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease (2020 edition).
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HIV関連骨粗鬆症に対するアレンドロネートの効果：無作為化、二重盲検、プラセボ対照、96週間の試験（ANRS 120）

Effect of alendronate on HIV-associated osteoporosis: a randomized, double-blind, placebo-controlled, 96-week trial (ANRS 120).
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イランの頭頸部癌患者における口腔咽頭カンジダ症から分離されたCandidaalbicansの遺伝子型解析。分子疫学とSAP2遺伝子発現

Genotyping of Candidaalbicans isolates from oropharyngeal candidiasis in head and neck cancer patients in Iran: Molecular epidemiology and SAP2 gene expression.
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IMRTを用いた胃リンパ腫の治療では、深部霊感ブレスホールドを用いて心臓の線量を減少させる

Decreased heart dose with deep inspiration breath hold for the treatment of gastric lymphoma with IMRT.
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抗PfGARPは寄生虫のプログラム細胞死を活性化し、重症マラリアを軽減します

Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria.
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27-ヒドロキシコレステロールの性差炎症効果は、エストロゲンのシグナル伝達の違いを介して媒介される

Sex-opposed inflammatory effects of 27-hydroxycholesterol are mediated via differences in estrogen signaling.
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N-メチル-d-アスパラギン酸受容体拮抗薬MK-801（ジゾシルピン）がマウスの骨の恒常性に及ぼす影響

Effects of N-methyl-d-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice.
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顔面神経シュワノーマに対する定位放射線手術における解剖学的分節浸潤の影響。国際的な多施設コホート研究

Effect of Anatomic Segment Involvement on Stereotactic Radiosurgery for Facial Nerve Schwannomas: An International Multicenter Cohort Study.
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ブラジルの様々な牛種における Rhipicephalus microplus ダニと Anaplasma marginale 感染との相関

Correlation between Rhipicephalus microplus ticks and Anaplasma marginale infection in various cattle breeds in Brazil.
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中国南西部のHIV/AIDS患者の長期死亡率に及ぼす抗レトロウイルス療法開始時のAIDS定義イベントの影響：レトロスペクティブコホート研究

Effect of AIDS-defining events at initiation of antiretroviral therapy on long-term mortality of HIV/AIDS patients in Southwestern China: a retrospective cohort study.
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B型慢性肝炎に対するベシフォビルジピボキシルマレイン酸塩の144週間投与。第 3 相試験の非盲検延長試験

Besifovir Dipivoxil Maleate 144-Week Treatment of Chronic Hepatitis B: An Open-Label Extensional Study of a Phase 3 Trial.
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ベバシズマブは化学療法誘発性脾臓機能亢進症の管理における部分的な脾臓塞栓術の有効性に影響を与えない

Bevacizumab Does Not Influence the Efficacy of Partial Splenic Embolization in the Management of Chemotherapy-Induced Hypersplenism.
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耐性統合失調症患者におけるCOVID-19の好発進と本剤とパルミチン酸パリペリドンの併用についての考察

[Thoughts on a favourable evolution of a COVID-19 in a patient with resistant schizophrenia and on a combination of clozapine and paliperidone palmitate].
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ゴルジ体の組織はプロテアソーム分解によって制御されている

Golgi organization is regulated by proteasomal degradation.
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原発性骨粗鬆症における間葉系幹細胞集団の転写プロファイルは明瞭であり、骨形成阻害剤の過剰発現を示す

The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors.
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大動脈弁狭窄症患者における脳卒中量と大動脈弁面積の推定．心エコー検査と心血管磁気共鳴検査の比較

Estimation of Stroke Volume and Aortic Valve Area in Patients with Aortic Stenosis: A Comparison of Echocardiography versus Cardiovascular Magnetic Resonance.
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振動分光マップ、振動分光、分子間相互作用

Vibrational Spectroscopic Map, Vibrational Spectroscopy, and Intermolecular Interaction.
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COVID-19患者における呼吸不全に対する静脈体外膜酸素療法．北米の主要な学術医療センターからの初期の経験

Veno-venous Extracorporeal Membrane Oxygenation for Respiratory Failure in COVID-19 Patients: Early Experience From a Major Academic Medical Center in North America.
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シロイヌナズナにおけるABAシグナル伝達ターミネーターによる種子発芽・育苗阻害のカウンターアクション（英文

Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis.
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  • Tao Wang
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  • Yang Zhao
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  • Xinying Wu
  • Shimin Xu
  • Mengmeng Cao
  • Hongtao Zhao
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  • Jiankang Zhu
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犬および猫における外傷性頭蓋骨骨折。神経学的およびコンピュータ断層撮影機能の比較分析

Traumatic skull fractures in dogs and cats: A comparative analysis of neurological and computed tomographic features.
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ウミウシは、海藻類である Laurencia dendroidea とその近縁種において化学防御の誘導を促進する

The sea-hare Aplysia brasiliana promotes induction in chemical defense in the seaweed Laurencia dendroidea and in their congeneric neighbors.
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  • Plant Physiol. Biochem..2020 Jun;154:295-303. S0981-9428(20)30244-8. doi: 10.1016/j.plaphy.2020.05.020.Epub 2020-06-17.

CYP3A4誘導を抑制する新たなアプローチにより、最適なADMETプロファイルを持つ強力なB型肝炎ウイルス（HBV）カプシドインヒビターが発見されました

A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles.
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  • Weixing Zhang
  • Zongxing Qiu
  • Zheng Zhou
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  • Hongxia Qiu
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  • Xue Zhou
  • Guang Yang
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非小細胞肺癌におけるALK遺伝子増幅とコピー数増加の非生産的効果.NSCLCにおけるALK遺伝子増幅とコピー数ゲイン

Unproductive Effects of ALK Gene Amplification and Copy Number Gain in Non-Small-Cell Lung Cancer. ALK Gene Amplification and Copy Gain in NSCLC.
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  • Gerardo Botti
  • Gabriella Aquino
  • Stefano Ferrero
  • Gabriella Gaudioso
  • Alessandro Palleschi
  • Danilo Rocco
  • Rosario Salvi
  • Maria Carolina Micheli
  • Pietro Micheli
  • Alessandro Morabito
  • Gaetano Rocco
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  • Rossella De Cecio
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ルセットバット樹状細胞は、プロ炎症性疾患メディエーターをダウンレギュレーションしながら、インターフェロン関連遺伝子のアップレギュレーションによってマールブルグウイルス媒介の抗ウイルス応答を克服する

Rousette Bat Dendritic Cells Overcome Marburg Virus-Mediated Antiviral Responses by Upregulation of Interferon-Related Genes While Downregulating Proinflammatory Disease Mediators.
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  • mSphere.2019 12;4(6). e00728-19. doi: 10.1128/mSphere.00728-19.Epub 2019-12-04.

好中球対リンパ球比（NLR）が高いと，チカグレラーとの二重抗血小板療法を受けているACS患者において，最適な血小板抑制効果が得られず，大規模な心血管虚血イベントが発生するリスクが高くなる．

Higher neutrophil-to-lymphocyte ratio (NLR) increases the risk of suboptimal platelet inhibition and major cardiovascular ischemic events among ACS patients receiving dual antiplatelet therapy with ticagrelor.
  • Monica Verdoia
  • Matteo Nardin
  • Rocco Gioscia
  • Federica Negro
  • Marco Marcolongo
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  • Vascul. Pharmacol..2020 Jul;:106765. S1537-1891(20)30072-0. doi: 10.1016/j.vph.2020.106765.Epub 2020-07-15.

首都の主要パンデミック対策センターのCOVID-19の経験。トルコでのパンデミックの最初の1ヶ月間の結果

COVID-19 experience of the major pandemic response center in the capital: Results of the pandemic's first month in Turkey.
  • Rahmet Güner
  • İmran Hasanoğlu
  • Bircan Kayaaslan
  • Adalet Aypak
  • Ayşe Kaya Kalem
  • Fatma Eser
  • Burcu Özdemir
  • Elif Mukime Sarıcaoğlu
  • Müge Ayhan
  • Yeşim Aybar Bilir
  • Işıl Özkoçak Turan
  • Deniz Erdem
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  • Turan Buzğan
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  • Esragül Akıncı
  • Turk J Med Sci.2020 07;doi: 10.3906/sag-2006-164.Epub 2020-07-19.

オートファジーとFGF21レベルが低いにもかかわらず、高タンパク食は低タンパク食よりも効果的に肝脂肪を減少させる

High-protein diet more effectively reduces hepatic fat than low-protein diet despite lower autophagy and FGF21 levels.
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  • Liver Int..2020 Jul;doi: 10.1111/liv.14596.Epub 2020-07-11.

CD27 および CD70 欠損症における臨床および免疫学的表現型の拡大と移植転帰

Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency.
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  • Sule Haskologlu
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  • Kubra Baskin
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  • Ebru Yilmaz
  • Ekrem Unal
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  • Marco Gattorno
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  • Lennart Hammarström
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  • Blood.2020 Jun;blood.2020006738. doi: 10.1182/blood.2020006738.Epub 2020-06-30.