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犬の大腸担子菌症
Colorectal basidiobolomycosis in a dog.
PMID: 32681715 DOI: 10.1111/jvim.15859.
抄録
7歳の去勢済み雄フレンチブルドッグが慢性大腸腸症のため受診した。大腸腫瘤と肥厚した直腸粘膜が確認され、内視鏡的生検標本の病理組織学的検査では、大きな（5～20μm）不規則な形をした黄斑点状のハイパーを伴う好酸球性の直腸炎が認められ、五森メテナミン銀および周期的酸-Schiff陽性であった。パラフィン包埋組織から抽出したリボソームDNAを増幅して配列を決定したところ、GenBankの塩基配列と97％の同一性を持つ塩基配列が得られた。イトラコナゾール，テルビナフィン，プレドニゾン投与後，臨床症状は急速に消失し，6週間後にはソノグラフィー病変はほとんど消失した．診断から15週後に飼い主が治療を中止した．3週間後、犬は急性に倒れ、安楽死した。剖検の結果、転移性膵島細胞癌と大腸組織に目立った異常はなかった。しかし、直腸の病理組織学的検査では、以前に観察されたものと類似した形態の多巣性粘膜下肉芽腫が認められた。本報告は、イヌの消化管担子状菌症の内科的治療について初めて述べたものである。
A 7-year-old castrated male French Bulldog was examined for chronic large intestinal enteropathy. A colonic mass and thickened rectal mucosa were identified, and histopathologic examination of endoscopic biopsy specimens disclosed eosinophilic proctitis with large (5-20 μm), irregularly shaped, pauciseptate hyphae that were Gomori methenamine silver and periodic acid-Schiff positive. Amplification and sequencing of ribosomal DNA extracted from paraffin-embedded tissues yielded a sequence with 97% identity to GenBank sequences for Basidiobolus ranarum. After itraconazole, terbinafine, and prednisone administration, clinical signs resolved rapidly, and sonographic lesions were largely absent after 6 weeks. Treatment was discontinued by the owner 15 weeks after diagnosis. Three weeks later, the dog collapsed acutely and was euthanized. Necropsy identified metastatic islet cell carcinoma and grossly unremarkable colorectal tissues. However, histopathology of the rectum disclosed multifocal submucosal granulomas with intralesional hyphae morphologically similar to those previously observed. This report is the first to describe medical treatment of gastrointestinal basidiobolomycosis in a dog.
© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine.