あなたは歯科・医療関係者ですか？

WHITE CROSSは、歯科・医療現場で働く方を対象に、良質な歯科医療情報の提供を目的とした会員制サイトです。

日本語AIでPubMedを検索

歯科医師情報サイトTOP / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
対象期間    ～ 

2020年07月 みんなが読んでいる論文

RST1とRIPRはシロイヌナズナの細胞質RNAエクソソームとスキー複合体に接続している

RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis.
  • Heike Lange
  • Simon Y A Ndecky
  • Carlos Gomez-Diaz
  • David Pflieger
  • Nicolas Butel
  • Julie Zumsteg
  • Lauriane Kuhn
  • Christina Piermaria
  • Johana Chicher
  • Michael Christie
  • Ezgi S Karaaslan
  • Patricia L M Lang
  • Detlef Weigel
  • Hervé Vaucheret
  • Philippe Hammann
  • Dominique Gagliardi
  • Nat Commun.2019 08;10(1):3871. 10.1038/s41467-019-11807-4. doi: 10.1038/s41467-019-11807-4.Epub 2019-08-27.

腹腔内感染後の敗血症性ショックからの回復に対するフィソスチグミンの効果 - 無作為化、二重盲検、プラセボ対照、単心パイロット試験の結果（Anticholium® per Se）

Effect of physostigmine on recovery from septic shock following intra-abdominal infection - Results from a randomized, double-blind, placebo-controlled, monocentric pilot trial (Anticholium® per Se).
  • Nadine Pinder
  • Thomas Bruckner
  • Monika Lehmann
  • Johann Motsch
  • Thorsten Brenner
  • Jan Larmann
  • Phillip Knebel
  • Torsten Hoppe-Tichy
  • Stefanie Swoboda
  • Markus A Weigand
  • Stefan Hofer
  • Johannes B Zimmermann
  • J Crit Care.2019 08;52:126-135. S0883-9441(19)30098-X. doi: 10.1016/j.jcrc.2019.04.012.Epub 2019-04-09.

補完代替医療（CAM）の医師の態度と認識。多拠点イタリアの研究

Physician Attitudes and Perceptions of Complementary and Alternative Medicine (CAM): A Multicentre Italian Study.
  • Massimiliano Berretta
  • Luca Rinaldi
  • Rosaria Taibi
  • Paolo Tralongo
  • Alberto Fulvi
  • Vincenzo Montesarchio
  • Giordano Madeddu
  • Paolo Magistri
  • Sabrina Bimonte
  • Marco Trovò
  • Patrizia Gnagnarella
  • Arturo Cuomo
  • Marco Cascella
  • Arben Lleshi
  • Guglielmo Nasti
  • Sergio Facchini
  • Francesco Fiorica
  • Raffaele Di Francia
  • Giuseppe Nunnari
  • Giovanni Francesco Pellicanò
  • Aurelio Guglielmino
  • Marco Danova
  • Sabrina Rossetti
  • Alfonso Amore
  • Anna Crispo
  • Gaetano Facchini
  • Front Oncol.2020;10:594. doi: 10.3389/fonc.2020.00594.Epub 2020-04-28.

プロゲステロン受容体を選択的に阻害した骨粗鬆症細胞を持つマウスのコラーゲン誘導性関節炎に対する高い感受性

High susceptibility to collagen-induced arthritis in mice with progesterone receptors selectively inhibited in osteoprogenitor cells.
  • Lixian Liu
  • Junjing Jia
  • Min Jiang
  • Xueping Liu
  • Chenling Dai
  • Barton L Wise
  • Nancy E Lane
  • Wei Yao
  • Arthritis Res. Ther..2020 Jul;22(1):165. 10.1186/s13075-020-02242-8. doi: 10.1186/s13075-020-02242-8.Epub 2020-07-02.

遺伝性心疾患における二次的所見：表現型、行動、心理社会的転帰を評価するための遺伝子型第一原理研究

Secondary findings in inherited heart conditions: a genotype-first feasibility study to assess phenotype, behavioural and psychosocial outcomes.
  • Elizabeth Ormondroyd
  • Andrew R Harper
  • Kate L Thomson
  • Michael P Mackley
  • Jennifer Martin
  • Christopher J Penkett
  • Silvia Salatino
  • Hannah Stark
  • Jonathan Stephens
  • Hugh Watkins
  • Eur. J. Hum. Genet..2020 Jul;10.1038/s41431-020-0694-9. doi: 10.1038/s41431-020-0694-9.Epub 2020-07-20.

都市排水中の14種類のサイトスタティックスを迅速に定量し、水生生物相への影響を調べるための簡単なツールとして液-液抽出を行いました

Liquid-liquid extraction as a simple tool to quickly quantify fourteen cytostatics in urban wastewaters and access their impact in aquatic biota.
  • Teresa I A Gouveia
  • Adrián M T Silva
  • Ana R Ribeiro
  • Arminda Alves
  • Mónica S F Santos
  • Sci. Total Environ..2020 Jun;740:139995. S0048-9697(20)33515-4. doi: 10.1016/j.scitotenv.2020.139995.Epub 2020-06-05.

アケボノハエのマリナー要素の進化史から、昆虫からのトランスポゾンが刺胞動物であるヒドラ・バルガリスのゲノムに水平移動していることが明らかになった

The evolutionary history of mariner elements in stalk-eyed flies reveals the horizontal transfer of transposons from insects into the genome of the cnidarian Hydra vulgaris.
  • C Alastair Grace
  • Martin Carr
  • PLoS ONE.2020;15(7):e0235984. PONE-D-20-11398. doi: 10.1371/journal.pone.0235984.Epub 2020-07-13.

アサロン酸は、IL-4Rα-Tyk2-STAT6とGLUT1-Akt-mTOR-AMPKの協調的シグナル伝達の形成を阻害することにより、グルコース誘発M2分極を阻害した

Asaronic Acid Inhibited Glucose-Triggered M2-Phenotype Shift Through Disrupting the Formation of Coordinated Signaling of IL-4Rα-Tyk2-STAT6 and GLUT1-Akt-mTOR-AMPK.
  • Hyeongjoo Oh
  • Sin-Hye Park
  • Min-Kyung Kang
  • Yun-Ho Kim
  • Eun-Jung Lee
  • Dong Yeon Kim
  • Soo-Il Kim
  • Su Yeon Oh
  • Woojin Na
  • Soon Sung Lim
  • Young-Hee Kang
  • Nutrients.2020 Jul;12(7). E2006. doi: 10.3390/nu12072006.Epub 2020-07-06.

70歳までの骨髄腫におけるボルテゾミブを用いた導入療法、高用量メルファラン、レナリドミド維持療法

Bortezomib-based induction, high-dose melphalan and lenalidomide maintenance in myeloma up to 70 years of age.
  • Elias K Mai
  • Kaya Miah
  • Uta Bertsch
  • Jan Dürig
  • Christof Scheid
  • Katja C Weisel
  • Christina Kunz
  • Markus Munder
  • Hans-Walter Lindemann
  • Maximilian Merz
  • Dirk Hose
  • Anna Jauch
  • Anja Seckinger
  • Steffen Luntz
  • Sandra Sauer
  • Stephan Fuhrmann
  • Peter Brossart
  • Ahmet Elmaagacli
  • Martin Goerner
  • Helga Bernhard
  • Martin Hoffmann
  • Marc S Raab
  • Igor W Blau
  • Mathias Hänel
  • Axel Benner
  • Hans J Salwender
  • Hartmut Goldschmidt
  • Leukemia.2020 Jul;10.1038/s41375-020-0976-9. doi: 10.1038/s41375-020-0976-9.Epub 2020-07-20.

15q13.3に位置するFAN1に共通する変異は、漢民族における統合失調症と双極性障害のリスクを示唆する

Common variants in FAN1, located in 15q13.3, confer risk for schizophrenia and bipolar disorder in Han Chinese.
  • Xuemin Jian
  • Jianhua Chen
  • Zhiqiang Li
  • Aamir Fahira
  • Weihuan Shao
  • Juan Zhou
  • Ke Wang
  • Yanqin Wen
  • Jinmai Zhang
  • Qiangzhen Yang
  • Dun Pan
  • Zhuo Wang
  • Yongyong Shi
  • Prog. Neuropsychopharmacol. Biol. Psychiatry.2020 Dec;103:109973. S0278-5846(20)30289-X. doi: 10.1016/j.pnpbp.2020.109973.Epub 2020-05-22.

小脳出血性脳梗塞後の逆行性栄養管移動を伴う口蓋咽喉頭ミオクローヌス：肥大性小葉変性症の症例報告とレビュー．

Palato-pharyngo-laryngeal myoclonus with recurrent retrograde feeding tube migration after cerebellar hemorrhagic stroke: a case report and review of hypertrophic olivary degeneration.
  • Jamie L Fleet
  • Ronelle Calver
  • Gihan C Perera
  • Zhihui Deng
  • BMC Neurol.2020 Jun;20(1):222. 10.1186/s12883-020-01800-6. doi: 10.1186/s12883-020-01800-6.Epub 2020-06-03.

培養ヒト歯根膜細胞は、複数の骨刺激性サイトカインや成長因子を構成的に発現しており、そのうちのいくつかは機械的変形に反応します

Cultured human periodontal ligament cells constitutively express multiple osteotropic cytokines and growth factors, several of which are responsive to mechanical deformation.
  • Mark N Pinkerton
  • David C Wescott
  • Benjamin J Gaffey
  • Kyle T Beggs
  • Trudy J Milne
  • Murray C Meikle
  • J. Periodont. Res..2008 Jun;43(3):343-51. JRE1040. doi: 10.1111/j.1600-0765.2007.01040.x.Epub 2007-12-17.

新規なB型肝炎ウイルスのカプシド集合体モジュレーターは、強力な抗ウイルス応答を誘導し、ヒト化マウスにおいても

Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses and in Humanized Mice.
  • Franck Amblard
  • Sebastien Boucle
  • Leda Bassit
  • Bryan Cox
  • Ozkan Sari
  • Sijia Tao
  • Zhe Chen
  • Tugba Ozturk
  • Kiran Verma
  • Olivia Russell
  • Virgile Rat
  • Hugues de Rocquigny
  • Oriane Fiquet
  • Maud Boussand
  • James Di Santo
  • Helene Strick-Marchand
  • Raymond F Schinazi
  • Antimicrob. Agents Chemother..2020 01;64(2). e01701-19. doi: 10.1128/AAC.01701-19.Epub 2020-01-27.

ラムダシアロトリンに曝露したOreochromis niloticus魚とタイムパウダー（Thymus vulgaris L.）を同時に給与した場合の免疫学的および酸化反応の二重反応。ストレスと免疫をコードする遺伝子の発現

Dual immunological and oxidative responses in Oreochromis niloticus fish exposed to lambda cyhalothrin and concurrently fed with Thyme powder (Thymus vulgaris L.): Stress and immune encoding gene expression.
  • Samah R Khalil
  • Yasser Abd Elhakim
  • Amir H Abd El-Fattah
  • Mayada Ragab Farag
  • Noura E Abd El-Hameed
  • Abd Elhakeem El-Murr
  • Fish Shellfish Immunol..2020 May;100:208-218. S1050-4648(20)30167-4. doi: 10.1016/j.fsi.2020.03.009.Epub 2020-03-09.

次世代を守る。生殖器からの共生細菌がボブテールイカの卵を真菌のファウリングから保護する

Shielding the Next Generation: Symbiotic Bacteria from a Reproductive Organ Protect Bobtail Squid Eggs from Fungal Fouling.
  • Allison H Kerwin
  • Samantha M Gromek
  • Andrea M Suria
  • Robert M Samples
  • Dister J Deoss
  • Kerry O'Donnell
  • Salvatore Frasca
  • Deanna A Sutton
  • Nathan P Wiederhold
  • Marcy J Balunas
  • Spencer V Nyholm
  • mBio.2019 10;10(5). e02376-19. doi: 10.1128/mBio.02376-19.Epub 2019-10-29.

窒素含有ビスフォスフォネートの骨への作用を調節します

regulates the action of nitrogen-containing bisphosphonates on bone.
  • Lauren E Surface
  • Damon T Burrow
  • Jinmei Li
  • Jiwoong Park
  • Sandeep Kumar
  • Cheng Lyu
  • Niki Song
  • Zhou Yu
  • Abbhirami Rajagopal
  • Yangjin Bae
  • Brendan H Lee
  • Steven Mumm
  • Charles C Gu
  • Jonathan C Baker
  • Mahshid Mohseni
  • Melissa Sum
  • Margaret Huskey
  • Shenghui Duan
  • Vinieth N Bijanki
  • Roberto Civitelli
  • Michael J Gardner
  • Chris M McAndrew
  • William M Ricci
  • Christina A Gurnett
  • Kathryn Diemer
  • Fei Wan
  • Christina L Costantino
  • Kristen M Shannon
  • Noopur Raje
  • Thomas B Dodson
  • Daniel A Haber
  • Jan E Carette
  • Malini Varadarajan
  • Thijn R Brummelkamp
  • Kivanc Birsoy
  • David M Sabatini
  • Gabe Haller
  • Timothy R Peterson
  • Sci Transl Med.2020 May;12(544). eaav9166. doi: 10.1126/scitranslmed.aav9166.

ミラベグロンの安全性と有効性：ミラベグロン、抗ムスカリン薬、プラセボを投与されている過活動膀胱患者を対象とした大規模統合臨床試験データベースの解析」についての編集コメント

Editorial commentary on "Safety and Efficacy of Mirabegron: Analysis of a Large Integrated Clinical Trial Database of Patients with Overactive Bladder Receiving Mirabegron, Antimuscarinics, or Placebo".
  • Tomonori Yamanishi
  • Tomohiko Kamasasko
  • Kanya Kaga
  • Miki Fuse
  • Transl Androl Urol.2020 Jun;9(3):1009-1012. tau-09-03-1009. doi: 10.21037/tau-2020-02.

硫酸インドキシルの濃度と時間は、アリール炭化水素受容体を介してNFATc1を制御し、破骨細胞形成に影響を与えることを明らかにした

Concentration and Duration of Indoxyl Sulfate Exposure Affects Osteoclastogenesis by Regulating NFATc1 via Aryl Hydrocarbon Receptor.
  • Wen-Chih Liu
  • Jia-Fwu Shyu
  • Paik Seong Lim
  • Te-Chao Fang
  • Chien-Lin Lu
  • Cai-Mei Zheng
  • Yi-Chou Hou
  • Chia-Chao Wu
  • Yuh-Feng Lin
  • Kuo-Cheng Lu
  • Int J Mol Sci.2020 May;21(10). E3486. doi: 10.3390/ijms21103486.Epub 2020-05-15.

地域保健センターを紹介している女性の中で、人口統計学的特徴と妊娠の試みと産後うつと不安との間の関連性。A Cross Sectional Study

The Association Between Demographic Characteristics and Attempting of Pregnancy with Postpartum Depression and Anxiety Among Women Referring to Community Health Centres: A Cross Sectional Study.
  • Maryam Alikamali
  • Sedigheh Khodabandeh
  • Maryam Motesaddi
  • Zeinab Bagheri
  • Mohammad Ali Esmaeili
  • Malays J Med Sci.2020 May;27(3):93-104. 10mjms2703_oa7. doi: 10.21315/mjms2020.27.3.10.Epub 2020-06-30.

骨単光子放出型コンピュータ断層撮影/コンピュータ断層撮影を用いた早期変形性関節症を伴う内側メニスカス後根部断裂の修復の予後予測．

Predicting outcome of repair of medial meniscus posterior root tear with early osteoarthritis using bone single-photon emission computed tomography/computed tomography.
  • Wonseok Whi
  • Jae-Young Park
  • Hongyoon Choi
  • Jin Chul Paeng
  • Gi Jeong Cheon
  • Keon Wook Kang
  • Dong Soo Lee
  • Hyuk-Soo Han
  • Medicine (Baltimore).2020 Jul;99(27):e21047. 00005792-202007020-00109. doi: 10.1097/MD.0000000000021047.

中国人ファンコニー貧血患者の表現型と遺伝的基盤を網羅的に解析：悲惨な結果から全国的な研究が求められている

Comprehensive analysis on phenotype and genetic basis of Chinese Fanconi anemia patients: dismal outcomes call for nationwide studies.
  • Daijing Nie
  • Jing Zhang
  • Fang Wang
  • Wei Zhang
  • Lili Liu
  • Xue Chen
  • Yang Zhang
  • Panxiang Cao
  • Min Xiong
  • Tong Wang
  • Ping Wu
  • Xiaoli Ma
  • Wenjun Tian
  • Mangju Wang
  • Kylan N Chen
  • Hongxing Liu
  • BMC Med. Genet..2020 Jun;21(1):118. 10.1186/s12881-020-01057-3. doi: 10.1186/s12881-020-01057-3.Epub 2020-06-01.

ブラジルの3つの湿地に生息する水鳥におけるヘモスポリジアンの多様性と有病率の空間分布に及ぼすベクターの生息地適性、環境要因、宿主特性の影響

Effects of habitat suitability for vectors, environmental factors and host characteristics on the spatial distribution of the diversity and prevalence of haemosporidians in waterbirds from three Brazilian wetlands.
  • Samira Chahad-Ehlers
  • Angela Terumi Fushita
  • Gustavo Augusto Lacorte
  • Pamela Carla Pereira de Assis
  • Silvia Nassif Del Lama
  • Parasit Vectors.2018 05;11(1):276. 10.1186/s13071-018-2847-z. doi: 10.1186/s13071-018-2847-z.Epub 2018-05-02.

副腎皮質がんを対象とした新規副腎特異的ステロールO-アシルトランスフェラーゼ1（SOAT1）阻害剤ネバニミベ塩酸塩の第1相試験

A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma.
  • David C Smith
  • Matthias Kroiss
  • Electron Kebebew
  • Mouhammed Amir Habra
  • Rashmi Chugh
  • Bryan J Schneider
  • Martin Fassnacht
  • Pegah Jafarinasabian
  • M Marian Ijzerman
  • Vivian H Lin
  • Pharis Mohideen
  • Aung Naing
  • Invest New Drugs.2020 Jan;10.1007/s10637-020-00899-1. doi: 10.1007/s10637-020-00899-1.Epub 2020-01-27.

ファーストコンタクト。7-フェニル-2-アミノキノリン、イソフォーム特異的なアスパラギン酸を標的とした強力かつ選択的な神経性一酸化窒素合成酵素阻害剤

First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
  • Maris A Cinelli
  • Cory T Reidl
  • Huiying Li
  • Georges Chreifi
  • Thomas L Poulos
  • Richard B Silverman
  • J. Med. Chem..2020 May;63(9):4528-4554. doi: 10.1021/acs.jmedchem.9b01573.Epub 2020-04-17.

アノオクタミン-1阻害活性を有するTrigonostemon honbaensis由来の置換トルキシン酸の4つの新規なショ糖ジエステル

Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity.
  • Ninh Khac Ban
  • Luu Hong Truong
  • Tran Van Tiep
  • Duong Thi Hai Yen
  • Vu Van Doan
  • Nguyen Xuan Nhiem
  • Yohan Seo
  • Wan Namkung
  • Seung Hyun Kim
  • Bui Huu Tai
  • Phan Van Kiem
  • Bioorg. Chem..2020 Jun;102:104058. S0045-2068(20)31355-9. doi: 10.1016/j.bioorg.2020.104058.Epub 2020-06-30.

空腹時血清総胆汁酸値は、2型糖尿病患者におけるグルコースチャレンジに対するインスリン感受性、膵島β細胞機能、およびグルカゴンレベルと関連している

Fasting serum total bile acid levels are associated with insulin sensitivity, islet β-cell function and glucagon levels in response to glucose challenge in patients with type 2 diabetes.
  • Xiao-Hua Wang
  • Feng Xu
  • Ming Cheng
  • Xing Wang
  • Dong-Mei Zhang
  • Li-Hua Zhao
  • Hong-Li Cai
  • Hai-Yan Huang
  • Tong Chen
  • Xiu-Lin Zhang
  • Xue-Qin Wang
  • Xing-Bo Cheng
  • Jian-Bin Su
  • Yan Lu
  • Endocr. J..2020 Jul;doi: 10.1507/endocrj.EJ20-0201.Epub 2020-07-17.

アストロサイトヒストン脱アセチル化酵素2は、グルタミン酸トランスポーター1をネガティブに制御することで、くも膜下出血後の遅発性抑うつと記憶障害を促進する

Astrocytic histone deacetylase 2 facilitates delayed depression and memory impairment after subarachnoid hemorrhage by negatively regulating glutamate transporter-1.
  • Kai Tao
  • Qing Cai
  • Xudong Zhang
  • Lin Zhu
  • Zhenru Liu
  • Fei Li
  • Qiang Wang
  • Lei Liu
  • Dayun Feng
  • Ann Transl Med.2020 Jun;8(11):691. atm-08-11-691. doi: 10.21037/atm-20-4330.

熱的に安定な有機金属ハライドペロブスカイトマイクロロッドのサイズ成長制御。二重ドーピング、格子ひずみ工学、反溶媒結晶化、バンドギャップ調整特性の相乗効果

Controlled Size Growth of Thermally Stable Organometallic Halide Perovskite Microrods: Synergistic Effect of Dual-Doping, Lattice Strain Engineering, Antisolvent Crystallization, and Band Gap Tuning Properties.
  • Mohammed Nazim
  • Jae Hyun Kim
  • ACS Omega.2020 Jul;5(26):16106-16119. doi: 10.1021/acsomega.0c01667.Epub 2020-06-22.

進行性皮膚線維症は、ヨーロッパの強皮症試験研究（EUSTAR）コホートにおけるびまん性皮膚全身性硬化症患者の肺機能の低下および生存率の悪化と関連している

Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort.
  • Wanlong Wu
  • Suzana Jordan
  • Nicole Graf
  • Janethe de Oliveira Pena
  • John Curram
  • Yannick Allanore
  • Marco Matucci-Cerinic
  • Janet E Pope
  • Christopher P Denton
  • Dinesh Khanna
  • Oliver Distler
  • Ann. Rheum. Dis..2019 05;78(5):648-656. annrheumdis-2018-213455. doi: 10.1136/annrheumdis-2018-213455.Epub 2019-03-09.

AHR1-ARNT1二量化ペアは、ニワトリにおいて、天然リガンドに対する反応の主要な調節因子であるが、TCDDに対する反応性はないことがわかった

The AHR1-ARNT1 dimerization pair is a major regulator of the response to natural ligands, but not to TCDD, in the chicken.
  • Dong-Hee Koh
  • Ji-Hee Hwang
  • Jae-Gon Park
  • Woo-Seon Song
  • Hisato Iwata
  • Eun-Young Kim
  • Ecotoxicol. Environ. Saf..2020 Sep;201:110835. S0147-6513(20)30674-6. doi: 10.1016/j.ecoenv.2020.110835.Epub 2020-06-17.

嚢胞性線維症患者におけるILC2の肺ホーミング。CCR6の機能的関与と呼吸不全への影響

ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure.
  • Anja Schulz-Kuhnt
  • Vicky Greif
  • Kai Hildner
  • Lisa Knipfer
  • Michael Döbrönti
  • Sabine Zirlik
  • Florian Fuchs
  • Raja Atreya
  • Sebastian Zundler
  • Rocío López-Posadas
  • Clemens Neufert
  • Andreas Ramming
  • Alexander Kiefer
  • Anika Grüneboom
  • Erwin Strasser
  • Stefan Wirtz
  • Markus F Neurath
  • Imke Atreya
  • Front Immunol.2020;11:691. doi: 10.3389/fimmu.2020.00691.Epub 2020-05-07.

Kv1.3はパーキンソン病における神経炎症と神経変性を調節している

Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.
  • Souvarish Sarkar
  • Hai M Nguyen
  • Emir Malovic
  • Jie Luo
  • Monica Langley
  • Bharathi N Palanisamy
  • Neeraj Singh
  • Sireesha Manne
  • Matthew Neal
  • Michelle Gabrielle
  • Ahmed Abdalla
  • Poojya Anantharam
  • Dharmin Rokad
  • Nikhil Panicker
  • Vikrant Singh
  • Muhammet Ay
  • Adhithiya Charli
  • Dilshan Harischandra
  • Lee-Way Jin
  • Huajun Jin
  • Srikant Rangaraju
  • Vellareddy Anantharam
  • Heike Wulff
  • Anumantha G Kanthasamy
  • J. Clin. Invest..2020 Jun;136174. doi: 10.1172/JCI136174.Epub 2020-06-29.

慢性大腸炎誘発性内臓痛は、静穏期の不安感の増加と関連している

Chronic colitis-induced visceral pain is associated with increased anxiety during quiescent phase.
  • Emmeline Salameh
  • Mathieu Meleine
  • Guillaume Gourcerol
  • Jean-Claude do Rego
  • Jean-Luc do Rego
  • Romain Legrand
  • Jonathan Breton
  • Moutaz Aziz
  • Charlène Guérin
  • Moïse Coëffier
  • Guillaume Savoye
  • Rachel Marion-Letellier
  • Am. J. Physiol. Gastrointest. Liver Physiol..2019 06;316(6):G692-G700. doi: 10.1152/ajpgi.00248.2018.Epub 2019-02-08.

チモキノン（2-イソプロピル-5-メチル-1，4-ベンゾキノン）の化学予防・抗がん剤としての作用。化学と生物学的効果

Thymoquinone (2-Isoprpyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects.
  • Anas Ahmad
  • Rakesh Kumar Mishra
  • Akshay Vyawahare
  • Ajay Kumar
  • Muneeb U Rehman
  • Wajhul Qamar
  • Abdul Quaiyoom Khan
  • Rehan Khan
  • Saudi Pharm J.2019 Dec;27(8):1113-1126. S1319-0164(19)30122-7. doi: 10.1016/j.jsps.2019.09.008.Epub 2019-09-25.

実験的チャレンジの際に、従来の仔羊を対象としたいくつかの自家産および／または市販のワクチン接種プログラムによって与えられたコリバチルス症に対する保護のレベルの評価

An Assessment of the Level of Protection Against Colibacillosis Conferred by Several Autogenous and/or Commercial Vaccination Programs in Conventional Pullets upon Experimental Challenge.
  • Dimitris Koutsianos
  • Hubert Gantelet
  • Giovanni Franzo
  • Mathilde Lecoupeur
  • Eric Thibault
  • Mattia Cecchinato
  • Konstantinos C Koutoulis
  • Vet Sci.2020 Jun;7(3). E80. doi: 10.3390/vetsci7030080.Epub 2020-06-30.

遠隔虚血性前処理は、経皮的冠動脈造影を受ける中等度の腎障害を有する患者における造影誘発性腎症のリスクを低下させる。メタアナリシス

Remote Ischemic Preconditioning Reduces the Risk of Contrast-Induced Nephropathy in Patients with Moderate Renal Impairment Undergoing Percutaneous Coronary Angiography: A Meta-Analysis.
  • Jin Deng
  • Yi Lu
  • Jihong Ou
  • Xiaofei Shao
  • Xin Wang
  • Hongping Xie
  • Kidney Blood Press. Res..2020 Jul;:1-16. 000507330. doi: 10.1159/000507330.Epub 2020-07-20.

市販の ELISA キット、プロトタイプのマルチプレックス電気化学発光アッセイ、およびマルチプレックスビーズベース免疫測定法による尿由来の膀胱癌関連の診断シグネチャの検出法の比較

Comparison of Commercial ELISA Kits, a Prototype Multiplex Electrochemoluminescent Assay, and a Multiplex Bead-Based Immunoassay for Detecting a Urine-Based Bladder-Cancer-Associated Diagnostic Signature.
  • Hideki Furuya
  • Ian Pagano
  • Keanu Chee
  • Takashi Kobayashi
  • Regan S Wong
  • Riko Lee
  • Charles J Rosser
  • Diagnostics (Basel).2019 Oct;9(4). E166. doi: 10.3390/diagnostics9040166.Epub 2019-10-29.

ヒトIL6STにおける優性陰性突然変異は、高IgE症候群の原因となっています

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome.
  • Vivien Béziat
  • Simon J Tavernier
  • Yin-Huai Chen
  • Cindy S Ma
  • Marie Materna
  • Arian Laurence
  • Jens Staal
  • Dominik Aschenbrenner
  • Lisa Roels
  • Lisa Worley
  • Kathleen Claes
  • Lisa Gartner
  • Lisa A Kohn
  • Marieke De Bruyne
  • Klaus Schmitz-Abe
  • Louis-Marie Charbonnier
  • Sevgi Keles
  • Justine Nammour
  • Natasha Vladikine
  • Majistor Raj Luxman Maglorius Renkilaraj
  • Yoann Seeleuthner
  • Mélanie Migaud
  • Jérémie Rosain
  • Mohamed Jeljeli
  • Bertrand Boisson
  • Eva Van Braeckel
  • Jill A Rosenfeld
  • Hongzheng Dai
  • Lindsay C Burrage
  • David R Murdock
  • Bart N Lambrecht
  • Véronique Avettand-Fenoel
  • Tiphanie P Vogel
  • Charles R Esther
  • Sule Haskologlu
  • Figen Dogu
  • Peter Ciznar
  • David Boutboul
  • Marie Ouachée-Chardin
  • Jean Amourette
  • Marie-Noëlle Lebras
  • Clément Gauvain
  • Colas Tcherakian
  • Aydan Ikinciogullari
  • Rudi Beyaert
  • Laurent Abel
  • Joshua D Milner
  • Bodo Grimbacher
  • Louis-Jean Couderc
  • Manish J Butte
  • Alexandra F Freeman
  • Émilie Catherinot
  • Claire Fieschi
  • Talal A Chatila
  • Stuart G Tangye
  • Holm H Uhlig
  • Filomeen Haerynck
  • Jean-Laurent Casanova
  • Anne Puel
  • J. Exp. Med..2020 Jun;217(6). e20191804. doi: 10.1084/jem.20191804.

Toll-like receptor 9 1635A/G多型は、抗レトロウイルス療法を4週間中断した後のHIV-1リバウンドと関連している

Toll-like receptor 9 1635A/G polymorphism is associated with HIV-1 rebound after four weeks of interruption of antiretroviral therapy.
  • Alejandro Vallejo
  • Sonia Molina-Pinelo
  • Beatriz De Felipe
  • María Abad-Fernández
  • María Francisca González-Escribano
  • Manuel Leal
  • Natalia Soriano-Sarabia
  • J. Acquir. Immune Defic. Syndr..2020 Jul;doi: 10.1097/QAI.0000000000002437.Epub 2020-07-08.

筋肉内脂肪細胞のトランスクリプトームネットワークに関連付けられた DNA メチル化の風景は、ニワトリの筋肉内脂肪沈着の洞察を生成します

The Landscape of DNA Methylation Associated With the Transcriptomic Network of Intramuscular Adipocytes Generates Insight Into Intramuscular Fat Deposition in Chicken.
  • Meng Zhang
  • Donghua Li
  • Yanhui Zhai
  • Zhengzhu Wang
  • Xiangfei Ma
  • Daoyu Zhang
  • Guoxi Li
  • Ruili Han
  • Ruirui Jiang
  • Zhuanjian Li
  • Xiangtao Kang
  • Guirong Sun
  • Front Cell Dev Biol.2020;8:206. doi: 10.3389/fcell.2020.00206.Epub 2020-04-02.

サリニペプチンゲノム解析と化学的アプローチを統合して、グレートソルトレイクのストレプトマイセス属細菌由来の珍しいd-アミノ酸含有リボソーム合成ペプチドと翻訳後修飾ペプチド（RiPPs）を明らかにした

Salinipeptins: Integrated Genomic and Chemical Approaches Reveal Unusual d-Amino Acid-Containing Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs) from a Great Salt Lake Streptomyces sp.
  • Zhuo Shang
  • Jaclyn M Winter
  • Christopher A Kauffman
  • Inho Yang
  • William Fenical
  • ACS Chem. Biol..2019 03;14(3):415-425. doi: 10.1021/acschembio.8b01058.Epub 2019-02-26.

忘れ去られていた9-アクリダノン系ヒドラゾンであるRo 15-5458の有効性，代謝および薬物動態

Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.
  • Alexandra Probst
  • Cécile Häberli
  • Dionicio Siegel
  • Jianbo Huang
  • Seth Vigneron
  • Anh P Ta
  • Danielle E Skinner
  • Nelly El-Sakkary
  • Jeremiah D Momper
  • Jon Gangoiti
  • Yuxiang Dong
  • Jonathan L Vennerstrom
  • Susan A Charman
  • Conor R Caffrey
  • Jennifer Keiser
  • J. Antimicrob. Chemother..2020 Jul;dkaa247. doi: 10.1093/jac/dkaa247.Epub 2020-07-02.

脳卒中発症から4.5時間以上のアルテプラーゼを用いた灌流CTによる静脈内血栓溶解療法

Intravenous Thrombolysis Guided by Perfusion CT with Alteplase in >4.5 Hours from Stroke Onset.
  • Manuel Medina-Rodriguez
  • Manuel Millan-Vazquez
  • Elena Zapata-Arriaza
  • Irene Escudero
  • Blanca Pardo-Galiana
  • Juan Antonio Cabezas-Rodriguez
  • Lucia Lebrato-Hernandez
  • Joaquin Ortega-Quintanilla
  • Asier de Albóniga-Chindurza
  • Rafael Felix Ocete-Perez
  • Juan Jurado-Serrano
  • Alejandro Gonzalez-Garcia
  • Aurelio Cayuela
  • Francisco Moniche
  • Cerebrovasc. Dis..2020 Jul;:1-6. 000509013. doi: 10.1159/000509013.Epub 2020-07-02.

KCNQ2関連てんかん脳症のノックインマウスモデルでは、自発的な全身性発作と認知機能障害が認められた

A knock-in mouse model for KCNQ2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment.
  • Mathieu Milh
  • Pierre Roubertoux
  • Najoua Biba
  • Julie Chavany
  • Adeline Spiga Ghata
  • Camille Fulachier
  • Stephan Christopher Collins
  • Christel Wagner
  • Jean-Christophe Roux
  • Binnaz Yalcin
  • Marie-Solenne Félix
  • Florence Molinari
  • Pierre-Pascal Lenck-Santini
  • Laurent Villard
  • Epilepsia.2020 May;61(5):868-878. doi: 10.1111/epi.16494.Epub 2020-04-02.

ミトコンドリア神経消化管脳筋症（MNGIE）における肝移植：臨床的長期追跡調査と病原性の示唆

Liver transplantation in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): clinical long-term follow-up and pathogenic implications.
  • Roberto D'Angelo
  • Elisa Boschetti
  • Giulia Amore
  • Roberta Costa
  • Alessia Pugliese
  • Leonardo Caporali
  • Laura Ludovica Gramegna
  • Valentina Papa
  • Luca Vizioli
  • Mariantonietta Capristo
  • Manuela Contin
  • Susan Mohamed
  • Giovanna Cenacchi
  • Raffaele Lodi
  • Maria Cristina Morelli
  • Luca Fasano
  • Lara Pisani
  • Matteo Cescon
  • Caterina Tonon
  • Antonio Daniele Pinna
  • Maria Teresa Dotti
  • Francesco Sicurelli
  • Mauro Scarpelli
  • Massimiliano Filosto
  • Carlo Casali
  • Loris Pironi
  • Valerio Carelli
  • Roberto De Giorgio
  • Rita Rinaldi
  • J. Neurol..2020 Jul;10.1007/s00415-020-10051-x. doi: 10.1007/s00415-020-10051-x.Epub 2020-07-18.

Phyllanthus amarus Schum. and Thonn.の水抽出物の予防効果(Euphorbiaceae)の水性抽出物のDOCA-塩害による高血圧、心肥大と機能障害、ラットの内皮機能障害に対する予防的効果

Preventive Beneficial Effect of an Aqueous Extract of Phyllanthus amarus Schum. and Thonn. (Euphorbiaceae) on DOCA-Salt-Induced Hypertension, Cardiac Hypertrophy and Dysfunction, and Endothelial Dysfunction in Rats.
  • Nʼguessan Alain Yao
  • Zahid Rasul Niazi
  • Iveta Najmanová
  • Mamadou Kamagaté
  • Amissi Said
  • Philippe Chabert
  • Cyril Auger
  • Henri Die-Kakou
  • Valérie Schini-Kerth
  • J. Cardiovasc. Pharmacol..2020 Jun;75(6):573-583. doi: 10.1097/FJC.0000000000000825.

CR6-interacting factor 1欠損症は、テトラヒドロビオプテリンの生合成を阻害することで、内皮一酸化窒素合成酵素活性を低下させる

CR6-interacting factor 1 deficiency reduces endothelial nitric oxide synthase activity by inhibiting biosynthesis of tetrahydrobiopterin.
  • Ikjun Lee
  • Seonhee Kim
  • Harsha Nagar
  • Su-Jeong Choi
  • Byeong Hwa Jeon
  • Shuyu Piao
  • Cuk-Seong Kim
  • Sci Rep.2020 01;10(1):842. 10.1038/s41598-020-57673-9. doi: 10.1038/s41598-020-57673-9.Epub 2020-01-21.

Aptima Combo 2アッセイの感度、特異度、包接率、および排他性は、新しい診断回避型クラミジア・トラコマティスの検出範囲をカバーしています

Sensitivity, specificity, inclusivity and exclusivity of the updated Aptima Combo 2 assay, which provides detection coverage of the new diagnostic-escape Chlamydia trachomatis variants.
  • Magnus Unemo
  • Marit Hansen
  • Ronza Hadad
  • Mirja Puolakkainen
  • Henrik Westh
  • Kaisu Rantakokko-Jalava
  • Carina Thilesen
  • Michelle J Cole
  • Iryna Boiko
  • Pham T Lan
  • Daniel Golparian
  • Shin Ito
  • Martin Sundqvist
  • BMC Infect. Dis..2020 Jun;20(1):419. 10.1186/s12879-020-05148-7. doi: 10.1186/s12879-020-05148-7.Epub 2020-06-16.

SmbHLH53は、ジャスモネートシグナル伝達に関連しており、サルビアミルティホルヒザのサルビア酸B生合成経路の酵素遺伝子の調節に二重の役割を果たしていることが明らかになった

SmbHLH53 is relevant to jasmonate signaling and plays dual roles in regulating the genes for enzymes in the pathway for salvianolic acid B biosynthesis in Salvia miltiorrhiza.
  • Jing-Jing Peng
  • Yu-Cui Wu
  • Shi-Qiang Wang
  • Jun-Feng Niu
  • Xiao-Yan Cao
  • Gene.2020 Jun;756:144920. S0378-1119(20)30589-8. doi: 10.1016/j.gene.2020.144920.Epub 2020-06-25.

非侵襲的換気（NIV）に付された新生児の鼻の保護に対するハイドロコロイド対シリコーンゲル。無作為化臨床試験

Hydrocolloid versus silicone gel for the prevention of nasal injury in newborns submitted to noninvasive ventilation: A randomized clinical trial.
  • Débora de Fátima Camillo Ribeiro
  • Frieda Saicla Barros
  • Beatriz Luci Fernandes
  • Adriane Muller Nakato
  • Percy Nohama
  • Heliyon.2020 Jul;6(7):e04366. S2405-8440(20)31210-X. doi: 10.1016/j.heliyon.2020.e04366.Epub 2020-07-02.

共有結合的にグラフトされた2-メタクリロイルオキシエチルホスホリルコリンネットワークは、ポルシンモデルにおけるシリコーン乳房インプラント周囲の線維性カプセル形成を抑制する

Covalently Grafted 2-Methacryloyloxyethyl Phosphorylcholine Networks Inhibit Fibrous Capsule Formation around Silicone Breast Implants in a Porcine Model.
  • Jiyeon Ham
  • Youngmin Kim
  • Taeyang An
  • Sunah Kang
  • Cheolmin Ha
  • Maierdanjiang Wufue
  • Yumin Kim
  • Byoungjun Jeon
  • Seulah Kim
  • Jungah Kim
  • Tae Hyun Choi
  • Ji-Hun Seo
  • Dae Woo Kim
  • Ji-Ung Park
  • Yan Lee
  • ACS Appl Mater Interfaces.2020 Jul;12(27):30198-30212. doi: 10.1021/acsami.0c07629.Epub 2020-06-23.

感染症と前立腺がんの進行を結びつける。Toll-like Receptor3刺激は前立腺細胞のグルコース代謝をリワイヤリングする

Linking Infection and Prostate Cancer Progression: Toll-like Receptor3 Stimulation Rewires Glucose Metabolism in Prostate Cells.
  • Maria Chiara Magnifico
  • Alberto Macone
  • Marina Marani
  • Amani Bouzidi
  • Giorgio Giardina
  • Serena Rinaldo
  • Francesca Cutruzzolà
  • Alessio Paone
  • Anticancer Res..2019 Oct;39(10):5541-5549. 39/10/5541. doi: 10.21873/anticanres.13747.

駆出率が温存された心不全入院患者における血清尿酸の予後予測値（日本全国多施設共同登録から）

Prognostic Value of Serum Uric Acid in Hospitalized Heart Failure Patients With Preserved Ejection Fraction (from the Japanese Nationwide Multicenter Registry).
  • Yuta Kobayashi
  • Kazunori Omote
  • Toshiyuki Nagai
  • Kiwamu Kamiya
  • Takao Konishi
  • Takuma Sato
  • Yoshiya Kato
  • Hirokazu Komoriyama
  • Shingo Tsujinaga
  • Hiroyuki Iwano
  • Kazuhiro Yamamoto
  • Tsutomu Yoshikawa
  • Yoshihiko Saito
  • Toshihisa Anzai
  • Am. J. Cardiol..2020 03;125(5):772-776. S0002-9149(19)31351-7. doi: 10.1016/j.amjcard.2019.12.003.Epub 2019-12-09.

非小細胞肺がん患者およびがん誘発性骨痛患者における迅速な疼痛緩和に対するイバンドロネート負荷用量の有効性：NVALT-9試験

Efficacy of Ibandronate Loading Dose on Rapid Pain Relief in Patients With Non-Small Cell Lung Cancer and Cancer Induced Bone Pain: The NVALT-9 Trial.
  • Anita J W M Brouns
  • Lizza E L Hendriks
  • Vincent van der Noort
  • Ben E E M van de Borne
  • Franz M N H Schramel
  • Harry J M Groen
  • Bonne Biesma
  • Hans J M Smit
  • Anne-Marie C Dingemans
  • Front Oncol.2020;10:890. doi: 10.3389/fonc.2020.00890.Epub 2020-06-24.

腸球菌のMalRはマルトースオペロンの抑制因子として作用し、さらにセリルリン酸化HPrとの直接的な相互作用を介してマルトースの異化抑制を仲介している

Enterococcus faecalis MalR acts as a repressor of the maltose operons and additionally mediates their catabolite repression via direct interaction with seryl-phosphorylated-HPr.
  • Maxime Grand
  • Victor Sebastián Blancato
  • Martín Espariz
  • Josef Deutscher
  • Andreas Pikis
  • Axel Hartke
  • Christian Magni
  • Nicolas Sauvageot
  • Mol. Microbiol..2020 02;113(2):464-477. doi: 10.1111/mmi.14431.Epub 2019-12-11.

退役軍人の身体活動を促進するためのmHealthアプリに電話ベースのブリーフコーチングを追加することの効果。Stay Strongランダム化対照試験の結果

Effect of Adding Telephone-based Brief Coaching to a mHealth App for Promoting Physical Activity Among Veterans: Results from the Stay Strong Randomized Controlled Trial.
  • Laura J Damschroder
  • Lorraine R Buis
  • Felicia A McCant
  • H Myra Kim
  • Richard Evans
  • Eugene Z Oddone
  • Lori A Bastian
  • Gwendolyn Hooks
  • Reema Kadri
  • Courtney White-Clark
  • Caroline R Richardson
  • Jennifer M Gierisch
  • J. Med. Internet Res..2020 Jul;doi: 10.2196/19216.Epub 2020-07-07.

成長分化因子 9（growth differentiation factor 9）と骨形態形成蛋白質 15（bmp15）は、ヒラメのステロイド形成を制御する可能性があると考えられる

Growth differentiation factor 9 (gdf9) and bone morphogenetic protein 15 (bmp15) are potential intraovarian regulators of steroidogenesis in Japanese flounder (Paralichthys olivaceus).
  • Haiyang Yu
  • Yujue Wang
  • Mengya Wang
  • Yuxiang Liu
  • Jie Cheng
  • Quanqi Zhang
  • Gen. Comp. Endocrinol..2020 Jul;:113547. S0016-6480(20)30300-2. doi: 10.1016/j.ygcen.2020.113547.Epub 2020-07-10.

レセルピン誘発実験線維筋痛症モデルにおけるミトコンドリア機能不全の関連性

Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model.
  • Evelyne da Silva Brum
  • Maria Fernanda Pessano Fialho
  • Susana Paula Moreira Fischer
  • Diane Duarte Hartmann
  • Débora Farina Gonçalves
  • Rahisa Scussel
  • Ricardo Andrez Machado-de-Ávila
  • Cristiane Lenz Dalla Corte
  • Félix Alexandre Antunes Soares
  • Sara Marchesan Oliveira
  • Mol. Neurobiol..2020 Jul;10.1007/s12035-020-01996-1. doi: 10.1007/s12035-020-01996-1.Epub 2020-07-20.

微生物学的に生産されたデキストランとレバンのExopolysaccharidesによるブロイラーの腸内の一般的な腸内病原体の成長阻害

Growth Inhibition of Common Enteric Pathogens in the Intestine of Broilers by Microbially Produced Dextran and Levan Exopolysaccharides.
  • Iram Ashfaq
  • Hamza Amjad
  • Waqar Ahmad
  • Anam Nasir
  • Aamir Ali
  • Waqas Rafique Ali
  • Shazia Khaliq
  • Azam Hayat
  • Hazrat Ali
  • Fazal Sattar
  • M Afzal Ghauri
  • Munir A Anwar
  • Curr. Microbiol..2020 Jul;10.1007/s00284-020-02091-3. doi: 10.1007/s00284-020-02091-3.Epub 2020-07-13.

頭頸部がん放射線治療中および治療後の急性毒性の治療における鍼治療。無作為化プロスペクティブオープンラベル試験の中間解析

Acupuncture in the treatment of acute toxicity during and after head and neck cancer radiotherapy: Interim analysis of randomized prospective open-label trial.
  • Radana Dymackova
  • Tomas Kazda
  • Marek Slavik
  • Iveta Selingerova
  • Pavel Slampa
  • Ondrej Slama
  • Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub.2020 Jun;doi: 10.5507/bp.2020.021.Epub 2020-06-18.

TLR4/MYD88シグナル伝達経路を介したカイニン酸誘発てんかんラットにおけるイソリキリチゲニンの神経保護および抗炎症作用の検討

Neuroprotective and anti-inflammatory effects of isoliquiritigenin in kainic acid-induced epileptic rats via the TLR4/MYD88 signaling pathway.
  • Xiaobo Zhu
  • Jiankun Liu
  • Ou Chen
  • Jiang Xue
  • Shanying Huang
  • Weiwei Zhu
  • Yibiao Wang
  • Inflammopharmacology.2019 Dec;27(6):1143-1153. 10.1007/s10787-019-00592-7. doi: 10.1007/s10787-019-00592-7.Epub 2019-04-29.

生前前前帯状皮質から後基底扁桃体への有効な接続性の変化が、インターネットゲーム障害と孤独感の関係を媒介していることが明らかになった

Altered effective connectivity from the pregenual anterior cingulate cortex to the laterobasal amygdala mediates the relationship between internet gaming disorder and loneliness.
  • Min Wang
  • Ningning Zeng
  • Hui Zheng
  • Xiaoxia Du
  • Marc N Potenza
  • Guang-Heng Dong
  • Psychol Med.2020 Jul;:1-10. S0033291720002366. doi: 10.1017/S0033291720002366.Epub 2020-07-20.

5-アルキル-6-(ベンゾド1,3ジオキソール-5-アルキル)-2-メルカプトピリミジン-4(3H)-オン類の設計、合成および抗HIV薬としての評価

Design, synthesis and anti-HIV evaluation of 5-alkyl- 6-(benzo[d][1,3]dioxol-5-alkyl)-2-mercaptopyrimidin-4(3H)-ones as potent HIV-1 NNRTIs.
  • Yi-Ming Li
  • Rong-Hua Luo
  • Liu-Meng Yang
  • Si-Ming Huang
  • Sui-Yuan Li
  • Yu-Gui Zheng
  • Dong-Xuan Ni
  • Yi-Man Cui
  • Xing-Jie Zhang
  • Xiao-Li Li
  • Rui-Han Zhang
  • E Tang
  • Hong-Bin Zhang
  • Yong-Tang Zheng
  • Yan-Ping He
  • Wei-Lie Xiao
  • Bioorg. Chem..2020 Jun;102:104041. S0045-2068(20)31338-9. doi: 10.1016/j.bioorg.2020.104041.Epub 2020-06-26.

PDP1のTyrリン酸化は、ピルビン酸脱水素酵素複合体を制御するために、ACAT1とSIRT3の間のリクルートを切り替えます

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
  • Jun Fan
  • Changliang Shan
  • Hee-Bum Kang
  • Shannon Elf
  • Jianxin Xie
  • Meghan Tucker
  • Ting-Lei Gu
  • Mike Aguiar
  • Scott Lonning
  • Huaibin Chen
  • Moosa Mohammadi
  • Laura-Mae P Britton
  • Benjamin A Garcia
  • Maša Alečković
  • Yibin Kang
  • Stefan Kaluz
  • Narra Devi
  • Erwin G Van Meir
  • Taro Hitosugi
  • Jae Ho Seo
  • Sagar Lonial
  • Manila Gaddh
  • Martha Arellano
  • Hanna J Khoury
  • Fadlo R Khuri
  • Titus J Boggon
  • Sumin Kang
  • Jing Chen
  • Mol. Cell.2014 Feb;53(4):534-48. S1097-2765(14)00032-X. doi: 10.1016/j.molcel.2013.12.026.Epub 2014-01-30.

インターロイキン-6-174G/C多型はC型慢性肝炎ウイルス患者の2型糖尿病リスクの低下と関連している

Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus.
  • Cliviany Borges da Silva
  • Diego Alves Vieira
  • Luisa Freitas de Melo
  • Anna Luiza Soares Chagas
  • Adriana Dias Gomes
  • César Lúcio Lopes de Faria
  • Rosângela Teixeira
  • Dulciene Maria de Magalhães Queiroz
  • Gifone Aguiar Rocha
  • Maria Marta Sarquis Soares
  • Juliana Maria Trindade Bezerra
  • Luciana Diniz Silva
  • World J Hepatol.2020 Apr;12(4):137-148. doi: 10.4254/wjh.v12.i4.137.

COVID-19パンデミックに対するインドの対応における歴史的な国家的封鎖の予測、介入の役割、効果：データサイエンスからの呼びかけ

Predictions, role of interventions and effects of a historic national lockdown in India's response to the COVID-19 pandemic: data science call to arms.
  • Debashree Ray
  • Maxwell Salvatore
  • Rupam Bhattacharyya
  • Lili Wang
  • Jiacong Du
  • Shariq Mohammed
  • Soumik Purkayastha
  • Aritra Halder
  • Alexander Rix
  • Daniel Barker
  • Michael Kleinsasser
  • Yiwang Zhou
  • Debraj Bose
  • Peter Song
  • Mousumi Banerjee
  • Veerabhadran Baladandayuthapani
  • Parikshit Ghosh
  • Bhramar Mukherjee
  • Harv Data Sci Rev.2020;2020(Suppl 1). doi: 10.1162/99608f92.60e08ed5.Epub 2020-06-09.

過去10年間のアンダルシア（スペイン）における血流感染症の疫学的変化

Epidemiologic changes in bloodstream infections in Andalucía (Spain) during the last decade.
  • P M Martínez Pérez-Crespo
  • L E López-Cortés
  • P Retamar-Gentil
  • J F Lanz García
  • D Vinuesa García
  • E León
  • J M Sánchez Calvo
  • F Galán-Sánchez
  • C Natera Kindelan
  • A Del Arco Jiménez
  • A Sánchez-Porto
  • C Herrero Rodríguez
  • B Becerril Carral
  • I M Reche Molina
  • J M Reguera Iglesias
  • I Pérez Camacho
  • M Guzman García
  • I López-Hernández
  • J Rodríguez-Baño
  • Clin. Microbiol. Infect..2020 May;S1198-743X(20)30292-5. doi: 10.1016/j.cmi.2020.05.015.Epub 2020-05-26.

マバカムテンは、細いフィラメント肥大型心筋症の突然変異によって引き起こされる筋フィラメントカルシウム感受性の増加とCaフラックスの調節障害を救済する

Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca flux caused by thin filament hypertrophic cardiomyopathy mutations.
  • Alexander J Sparrow
  • Hugh Watkins
  • Matthew J Daniels
  • Charles Redwood
  • Paul Robinson
  • Am. J. Physiol. Heart Circ. Physiol..2020 03;318(3):H715-H722. doi: 10.1152/ajpheart.00023.2020.Epub 2020-02-21.

ガンマ線照射エキスは、ラットにおける5αリダクターゼのダウンレギュレーションとテストステロンの回復により、テストステロン誘発性前立腺肥大症を改善します

Gamma Irradiated Extract Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Downregulating 5-Alpha Reductase and Restoring Testosterone in Rats.
  • Qi Xin
  • Mi-Jin Kwon
  • Ju-Woon Lee
  • Kwan-Soo Kim
  • Hao Chen
  • Maria G Campos
  • Rosa Tundis
  • Cheng-Bi Cui
  • Young Ho Cho
  • Hui Cao
  • Molecules.2019 Nov;24(21). E3981. doi: 10.3390/molecules24213981.Epub 2019-11-04.

カリプラジンの長期投与により、海馬での脊髄性神経細胞の活動とセロトニン受容体の神経伝達が増加した

Long-term administration of cariprazine increases locus coeruleus noradrenergic neurons activity and serotonin receptor neurotransmission in the hippocampus.
  • Mostafa El Mansari
  • Mohammad Ebrahimzadeh
  • Rami Hamati
  • Chidibere M Iro
  • Bence Farkas
  • Béla Kiss
  • Nika Adham
  • Pierre Blier
  • J. Psychopharmacol. (Oxford).2020 Jul;:269881120936891. doi: 10.1177/0269881120936891.Epub 2020-07-20.

ニューデリーメタロ-β-ラクタマーゼ産生クレブシエラ肺炎菌分離株のポリミキシンBとクロラムフェニコールの併用に対するトランスクリプトーム応答

Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol.
  • Nusaibah Abdul Rahim
  • Soon-Ee Cheah
  • Matthew D Johnson
  • Yan Zhu
  • Heidi H Yu
  • Hanna E Sidjabat
  • Mark S Butler
  • Matthew A Cooper
  • Jing Fu
  • David L Paterson
  • Roger L Nation
  • John D Boyce
  • Phillip J Bergen
  • Tony Velkov
  • Jian Li
  • Int. J. Antimicrob. Agents.2020 Jun;:106061. S0924-8579(20)30231-4. doi: 10.1016/j.ijantimicag.2020.106061.Epub 2020-06-20.

合成カンナビノイドURB447は、新生児ラットにおける低酸素虚血後の脳損傷および関連する白質脱髄を減少させる

The Synthetic Cannabinoid URB447 Reduces Brain Injury and the Associated White Matter Demyelination after Hypoxia-Ischemia in Neonatal Rats.
  • Silvia Carloni
  • Rita Crinelli
  • Linda Palma
  • Francisco J Álvarez
  • Daniele Piomelli
  • Andrea Duranti
  • Walter Balduini
  • Daniel Alonso-Alconada
  • ACS Chem Neurosci.2020 05;11(9):1291-1299. doi: 10.1021/acschemneuro.0c00047.Epub 2020-04-22.

エピガロカテキンガレートは、カテキンではなく、緑茶抽出物と同様のマウスの非アルコール性脂肪肝炎を予防しますが、腸内細菌叢には異なる影響を与えます

Epigallocatechin gallate but not catechin prevents nonalcoholic steatohepatitis in mice similar to green tea extract while differentially affecting the gut microbiota.
  • Priyankar Dey
  • Bryan D Olmstead
  • Geoffrey Y Sasaki
  • Yael Vodovotz
  • Zhongtang Yu
  • Richard S Bruno
  • J. Nutr. Biochem..2020 Jun;84:108455. S0955-2863(20)30487-3. doi: 10.1016/j.jnutbio.2020.108455.Epub 2020-06-20.

時空間マッピングは、経口L-アルギニンサプリメントによって改善mdxジストロフィーマウスにおける地域の胃腸機能障害を明らかにする

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation.
  • Kristy Swiderski
  • Rebecka Bindon
  • Jennifer Trieu
  • Timur Naim
  • Shana Schokman
  • Mathusi Swaminathan
  • Anita J L Leembruggen
  • Elisa L Hill-Yardin
  • René Koopman
  • Joel C Bornstein
  • Gordon S Lynch
  • J Neurogastroenterol Motil.2020 Jan;26(1):133-146. jnm19029. doi: 10.5056/jnm19029.

単極性および双極性うつ病の重症度と期間による大うつ病エピソードの再構築：国際的な大規模観察研究における診断横断的クラスター分析

Deconstructing major depressive episodes across unipolar and bipolar depression by severity and duration: a cross-diagnostic cluster analysis on a large, international, observational study.
  • Filippo Corponi
  • Gerard Anmella
  • Isabella Pacchiarotti
  • Ludovic Samalin
  • Norma Verdolini
  • Dina Popovic
  • Jean-Michel Azorin
  • Jules Angst
  • Charles L Bowden
  • Sergey Mosolov
  • Allan H Young
  • Giulio Perugi
  • Eduard Vieta
  • Andrea Murru
  • Transl Psychiatry.2020 Jul;10(1):241. 10.1038/s41398-020-00922-2. doi: 10.1038/s41398-020-00922-2.Epub 2020-07-19.

エラグ酸は、サイクリン依存性キナーゼ6の阻害を介して乳がん細胞の増殖を制御し、アポトーシスを誘導する

Ellagic Acid Controls Cell Proliferation and Induces Apoptosis in Breast Cancer Cells via Inhibition of Cyclin-Dependent Kinase 6.
  • Mohd Yousuf
  • Anas Shamsi
  • Parvez Khan
  • Mohd Shahbaaz
  • Mohamed F AlAjmi
  • Afzal Hussain
  • Gulam Mustafa Hassan
  • Asimul Islam
  • Qazi Mohd Rizwanul Haque
  • Md Imtaiyaz Hassan
  • Int J Mol Sci.2020 May;21(10). E3526. doi: 10.3390/ijms21103526.Epub 2020-05-15.

集学的リハビリテーションの神経画像診断、生物学的、認知的、運動学的転帰に対する効果

The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington's disease.
  • Danielle M Bartlett
  • Andrew Govus
  • Timothy Rankin
  • Amit Lampit
  • Kirk Feindel
  • Govinda Poudel
  • Wei-Peng Teo
  • Johnny Lo
  • Nellie Georgiou-Karistianis
  • Mel R Ziman
  • Travis M Cruickshank
  • J. Neurol. Sci..2020 Jul;416:117022. S0022-510X(20)30359-2. doi: 10.1016/j.jns.2020.117022.Epub 2020-07-12.

2型糖尿病患者におけるベースラインおよび達成血圧に応じた心不全および腎アウトカム：EMPA-REG OUTCOMEの結果

Heart failure and renal outcomes according to baseline and achieved blood pressure in patients with type 2 diabetes: results from EMPA-REG OUTCOME.
  • Michael Böhm
  • David Fitchett
  • Anne Pernille Ofstad
  • Martina Brueckmann
  • Stefan Kaspers
  • Jyothis T George
  • Isabella Zwiener
  • Bernard Zinman
  • Christoph Wanner
  • Nikolaus Marx
  • Giuseppe Mancia
  • Stefan D Anker
  • Felix Mahfoud
  • J. Hypertens..2020 Jun;doi: 10.1097/HJH.0000000000002492.Epub 2020-06-25.

アクイラリア・シネンシスに感染したHeortia vitessoidesを防除するための周波数トレンブラーグリッドランプとトラップ植物を用いたトラップの効率性の評価

[Evaluation of efficiency of traps baited with frequency trembler grid lamps and trap plants for control Heortia vitessoides infectwed in Aquilaria sinensis].
  • Hai-Li Qiao
  • Chang-Qing Xu
  • Rong Xu
  • Kun Guo
  • Jian-He Wei
  • Xiang-Ming Li
  • Jun Chen
  • Zhongguo Zhong Yao Za Zhi.2016 Jun;41(11):2025-2029. doi: 10.4268/cjcmm20161109.

インターロイキン-9は、アドリアマイシン誘発性腎症における初期の鞘球傷害および進行性糸球体硬化症から保護します

Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.
  • Tingting Xiong
  • Madena Attar
  • Ann-Christin Gnirck
  • Malte Wunderlich
  • Martina Becker
  • Constantin Rickassel
  • Victor G Puelles
  • Catherine Meyer-Schwesinger
  • Thorsten Wiech
  • Jasper F Nies
  • Mylène Divivier
  • Tobias Fuchs
  • Julian Schulze Zur Wiesch
  • Hanna Taipaleenmäki
  • Elion Hoxha
  • Stefan Wirtz
  • Tobias B Huber
  • Ulf Panzer
  • Jan-Eric Turner
  • Kidney Int..2020 May;S0085-2538(20)30537-8. doi: 10.1016/j.kint.2020.04.036.Epub 2020-05-21.

典型的な従属栄養性硫化物酸化硝酸還元菌シュードモナスC27における硫化物と酸素に対する刺激的な代謝機構の応答

The stimulating metabolic mechanisms response to sulfide and oxygen in typical heterotrophic sulfide-oxidizing nitrate-reducing bacteria Pseudomonas C27.
  • Ruo-Chen Zhang
  • Chuan Chen
  • Wei Wang
  • Bo Shao
  • Xi-Jun Xu
  • Xu Zhou
  • Duu-Jong Lee
  • Nan-Qi Ren
  • Bioresour. Technol..2020 Aug;309:123451. S0960-8524(20)30723-9. doi: 10.1016/j.biortech.2020.123451.Epub 2020-04-27.

血管内皮増殖因子Aを標的とした軟部組織肉腫の蛍光ガイド下での可視化：第1相単施設臨床試験

Fluorescence-guided visualization of soft tissue sarcomas by targeting vascular endothelial growth factor-A: a phase 1 single-center clinical trial.
  • Pieter Jan Steinkamp
  • Bobby Klaas Pranger
  • Meifang Li
  • Matthijs D Linssen
  • Floris Jan Voskuil
  • Lukas B Been
  • Barbara L van Leeuwen
  • Albert J H Suurmeijer
  • Wouter B Nagengast
  • Schelto K Kruijff
  • Robert J van Ginkel
  • Gooitzen Michell van Dam
  • J. Nucl. Med..2020 Jul;jnumed.120.245696. doi: 10.2967/jnumed.120.245696.Epub 2020-07-17.

インドのカルワラ村における壊死性筋膜炎を含む急性皮膚・軟部組織感染症のアウトブレイク、2018年。リンパ系フィラリア症撲滅プログラムの公衆衛生への影響

An outbreak of acute skin and soft tissue infections including necrotizing fasciitis in Kalwala village, India, 2018: Public health implications for the lymphatic filariasis elimination program.
  • Kiran Kumar Maramraj
  • Kavitha Latha Ml
  • Tanzin Dikid
  • Sushma Choudhary
  • Sukrutha Reddy
  • Sudhir Kumar Jain
  • Sujeet Kumar Singh
  • Trans. R. Soc. Trop. Med. Hyg..2020 Jun;traa046. doi: 10.1093/trstmh/traa046.Epub 2020-06-20.

重み付け遺伝子共発現ネットワーク解析と免疫組織化学的検証を統合することで、PTGDS発現の低下が子宮内膜癌の生存率低下を予測した

Decreased PTGDS Expression Predicting Poor Survival of Endometrial Cancer by Integrating Weighted Gene Co-Expression Network Analysis and Immunohistochemical Validation.
  • Ruoyao Zou
  • Mingjun Zheng
  • Mingzi Tan
  • Haoya Xu
  • Nannan Luan
  • Liancheng Zhu
  • Cancer Manag Res.2020;12:5057-5075. 255753. doi: 10.2147/CMAR.S255753.Epub 2020-06-26.

多剤耐性グラム陰性菌感染症を有する中国人患者におけるポリミキシンBの治療薬モニタリングのための母集団薬物動態モデルと限定的サンプリング戦略

Population Pharmacokinetics and Limited Sampling Strategy for Therapeutic Drug Monitoring of Polymyxin B in Chinese Patients With Multidrug-Resistant Gram-Negative Bacterial Infections.
  • Peile Wang
  • Qiwen Zhang
  • Zhenfeng Zhu
  • Min Feng
  • Tongwen Sun
  • Jing Yang
  • Xiaojian Zhang
  • Front Pharmacol.2020;11:829. doi: 10.3389/fphar.2020.00829.Epub 2020-06-05.

トルコのメルシン県～タウルスにおける松葉針および半透膜装置由来の大気中有機塩素化合物（OCPs）濃度

Pine needle and semi-permeable membrane device derived organochlorine compounds (OCPs) concentrations in air in Mersin Province to Taurus, Turkey.
  • Birgul Mazmanci
  • Mehmet A Mazmanci
  • Cafer Turgut
  • Levent Atatanir
  • Melis Yalcin
  • Perihan B Kurt-Karakus
  • Bernhard Henkelmann
  • Karl-Werner Schramm
  • J Environ Sci Health B.2020 Jun;:1-10. doi: 10.1080/03601234.2020.1768782.Epub 2020-06-13.

九州の肉用牛のウシウイルス性下痢症感染症検出のためのと畜場調査

Slaughterhouse survey for detection of bovine viral diarrhea infection among beef cattle in Kyushu, Japan.
  • Mohammad Aref Agah
  • Kosuke Notsu
  • Heba M El-Khaiat
  • Genki Arikawa
  • Meiko Kubo
  • Shuya Mitoma
  • Tamaki Okabayashi
  • Hirohisa Mekata
  • Eslam Elhanafy
  • Hala El Daous
  • Thi Ngan Mai
  • Thi Huyen Nguyen
  • Norikazu Isoda
  • Yoshihiro Sakoda
  • Junzo Norimine
  • Satoshi Sekiguchi
  • J. Vet. Med. Sci..2019 Oct;81(10):1450-1454. doi: 10.1292/jvms.19-0045.Epub 2019-08-05.

乳房病理組織標本の一次診断のためのデジタル病理学：デジタル病理学の検証とトレーニングに関する革新的な検証とコンコーダンス研究

Digital pathology for the primary diagnosis of breast histopathological specimens: an innovative validation and concordance study on digital pathology validation and training.
  • Bethany Jill Williams
  • Andrew Hanby
  • Rebecca Millican-Slater
  • Anju Nijhawan
  • Eldo Verghese
  • Darren Treanor
  • Histopathology.2018 Mar;72(4):662-671. doi: 10.1111/his.13403.Epub 2017-12-11.

インドにおける精神科研修の評価。インド精神医学会の研究・教育・研修財団の支援のもと、若手精神科医を対象とした調査

Evaluation of psychiatry training in India: A survey of young psychiatrists under the aegis of research, education, and training foundation of Indian Psychiatric Society.
  • Sandeep Grover
  • Swapnajeet Sahoo
  • Balachander Srinivas
  • Adarsh Tripathi
  • Ajit Avasthi
  • Indian J Psychiatry.2018 Oct-Dec;60(4):445-460. IJPsy-60-445. doi: 10.4103/psychiatry.IndianJPsychiatry_334_18.

ヘミラビール(κ2-C,S)-チオエーテル官能化NHC配位子を有するハーフサンドイッチ型ルテニウム錯体の合成、特性評価、触媒作用及び生物学的応用

Synthesis, characterization, catalytic and biological application of half-sandwich ruthenium complexes bearing hemilabile (κ2-C,S)-thioether-functionalised NHC ligands.
  • Weiguang Chen
  • Julien Egly
  • Amalia I Poblador-Bahamonde
  • Aline Maisse-Francois
  • Stéphane Bellemin-Laponnaz
  • Thierry Achard
  • Dalton Trans.2020 Mar;49(10):3243-3252. doi: 10.1039/c9dt04825a.Epub 2020-02-25.

グラム陰性およびグラム陽性細菌に対するフルオプシンCの作用の標的の決定

Determining the Targets of Fluopsin C Action on Gram-Negative and Gram-Positive Bacteria.
  • Miguel Octavio Pérez Navarro
  • Guilherme Dilarri
  • Ane Stefano Simionato
  • Kathlen Grzegorczyk
  • Mickely Liuti Dealis
  • Barbara Gionco Cano
  • André Riedi Barazetti
  • Leandro Afonso
  • Andreas Lazaros Chryssafidis
  • Henrique Ferreira
  • Galdino Andrade
  • Front Microbiol.2020;11:1076. doi: 10.3389/fmicb.2020.01076.Epub 2020-06-04.

リファキシミンは、腸内細菌叢の多様性に影響を与えることなく、肝性脳症やエンドトキシン血症を改善します

Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity.
  • Kosuke Kaji
  • Hiroaki Takaya
  • Soichiro Saikawa
  • Masanori Furukawa
  • Shinya Sato
  • Hideto Kawaratani
  • Mitsuteru Kitade
  • Kei Moriya
  • Tadashi Namisaki
  • Takemi Akahane
  • Akira Mitoro
  • Hitoshi Yoshiji
  • World J. Gastroenterol..2017 Dec;23(47):8355-8366. doi: 10.3748/wjg.v23.i47.8355.

ミクログリアはアルコール依存性マウスにおける飲酒のエスカレーションを制御する：ゲノムとシナプスのドライバー

Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers.
  • Anna S Warden
  • Sarah A Wolfe
  • Sophia Khom
  • Florence P Varodayan
  • Reesha R Patel
  • Michael Q Steinman
  • Michal Bajo
  • Sarah E Montgomery
  • Roman Vlkolinsky
  • Tali Nadav
  • Ilham Polis
  • Amanda J Roberts
  • R Dayne Mayfield
  • R Adron Harris
  • Marisa Roberto
  • Biol. Psychiatry.2020 May;S0006-3223(20)31598-5. doi: 10.1016/j.biopsych.2020.05.011.Epub 2020-05-19.

多環芳香族炭化水素汚染土壌のファイトレメディエーションを促進するための白腐れ菌（Crucibulum laeve）の接種法の開発

Enhancing Salix viminalis L.-mediated phytoremediation of polycyclic aromatic hydrocarbon-contaminated soil by inoculation with Crucibulum laeve (white-rot fungus).
  • Xiaodong Ma
  • Xia Li
  • Junxiang Liu
  • Yunhe Cheng
  • Feifei Zhai
  • Zhenyuan Sun
  • Lei Han
  • Environ Sci Pollut Res Int.2020 Jul;10.1007/s11356-020-10125-3. doi: 10.1007/s11356-020-10125-3.Epub 2020-07-17.

ミトコンドリアターゲティング農薬のパネルを用いたHepG2およびRPTEC/TERT1細胞におけるミトコンドリア呼吸抑制のマルチパラメトリック評価

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals.
  • Wanda van der Stel
  • Giada Carta
  • Julie Eakins
  • Salihanur Darici
  • Johannes Delp
  • Anna Forsby
  • Susanne Hougaard Bennekou
  • Iain Gardner
  • Marcel Leist
  • Erik H J Danen
  • Paul Walker
  • Bob van de Water
  • Paul Jennings
  • Arch. Toxicol..2020 Jul;10.1007/s00204-020-02792-5. doi: 10.1007/s00204-020-02792-5.Epub 2020-07-18.

放射線性口腔乾燥症に対する有効単核細胞（E-MNC）を用いた細胞療法の第1相臨床試験（ヒト初）（放射線性口腔乾燥症に対するE-MNC療法に関するFIH試験）

Phase 1 clinical study of cell therapy with effective-mononuclear cells (E-MNC) for radiogenic xerostomia (first-in-human study) (FIH study on E-MNC therapy for radiogenic xerostomia).
  • Yoshinori Sumita
  • Naoki Iwamoto
  • Makoto Seki
  • Takako Yoshida
  • Ryo Honma
  • Mayumi Iwatake
  • Seigo Ohba
  • I Takashi
  • Yuka Hotokezaka
  • Hiroshi Harada
  • Shinichiro Kuroshima
  • Kazuhiro Nagai
  • Takayuki Asahara
  • I Atsushi Kawakam
  • Izumi Asahina
  • Medicine (Baltimore).2020 Jun;99(26):e20788. 00005792-202006260-00034. doi: 10.1097/MD.0000000000020788.

グルタチオンペルオキシダーゼファミリー。グルタチオンペルオキシダーゼファミリー：これらの抗酸化酵素の比較解析と金属や酸化剤に対する遺伝子発現の違い

Glutathione Peroxidase Family: A Comparative Analysis of These Antioxidant Enzymes and Differential Gene Expression to Metals and Oxidizing Agents.
  • Liliana L Cubas-Gaona
  • Patricia de Francisco
  • Ana Martín-González
  • Juan Carlos Gutiérrez
  • Microorganisms.2020 Jul;8(7). E1008. doi: 10.3390/microorganisms8071008.Epub 2020-07-05.

V2+V3特発性三叉神経痛の治療には、半月状神経節ラジオ波熱凝固術と比較して、ロータンドゥム孔、卵巣孔を介した末梢神経ラジオ波熱凝固術を用いた

The treatment of V2 + V3 idiopathic trigeminal neuralgia using peripheral nerve radiofrequency thermocoagulation via the foramen rotundum and foramen ovale compared with semilunar ganglion radiofrequency thermocoagulation.
  • Fei Zeng
  • Mengye Zhu
  • Quan Wan
  • Yi Yan
  • Changxi Li
  • Yong Zhang
  • Clin Neurol Neurosurg.2020 Jun;196:106025. S0303-8467(20)30368-1. doi: 10.1016/j.clineuro.2020.106025.Epub 2020-06-17.

ロングノンコーディングRNA SNHG12は、腎細胞癌におけるCDCA3のアップレギュレーションにより、腫瘍の進行とスニチニブ抵抗性を促進する

Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma.
  • Yuenan Liu
  • Gong Cheng
  • Ziwei Huang
  • Lin Bao
  • Jingchong Liu
  • Cheng Wang
  • Zhiyong Xiong
  • Lijie Zhou
  • Tianbo Xu
  • Di Liu
  • Hongmei Yang
  • Ke Chen
  • Xiaoping Zhang
  • Cell Death Dis.2020 Jul;11(7):515. 10.1038/s41419-020-2713-8. doi: 10.1038/s41419-020-2713-8.Epub 2020-07-08.

臨床分離株における低レベルポリミキシン耐性検出の難しさ：Rapid Polymyxin NPテスト、Colispotテスト、SuperPolymyxin培地の評価

Difficulty in detecting low levels of polymyxin resistance in clinical isolates: evaluation of Rapid Polymyxin NP test, Colispot Test and SuperPolymyxin medium.
  • O C Conceição-Neto
  • B S da Costa
  • L S Pontes
  • I C O Santos
  • M C Silveira
  • J R Cordeiro-Moura
  • N F Pereira
  • C B Tavares-Teixeira
  • R C Picão
  • C M Rocha-de-Souza
  • A P D Carvalho-Assef
  • New Microbes New Infect.2020 Jul;36:100722. S2052-2975(20)30074-3. doi: 10.1016/j.nmni.2020.100722.Epub 2020-06-25.

Frontline Science.TNF-αとGM-CSF1のプライミングは、Ras、PI3K-γ、好中球プロ炎症反応の活性化を促進するSOS1/2の役割を増大させる

Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.
  • Sabine Suire
  • Fernando C Baltanas
  • Anne Segonds-Pichon
  • Keith Davidson
  • Eugenio Santos
  • Phillip T Hawkins
  • Len R Stephens
  • J. Leukoc. Biol..2019 10;106(4):815-822. doi: 10.1002/JLB.2HI0918-359RR.Epub 2019-02-05.

高リスクの心臓外科手術における死亡率を予測するための加算ロジスティック・ヨーロッパ心臓手術リスクシステム（EuroSCORE）とEuroSCORE 2の比較

Comparison of the additive, logistic european system for cardiac operative risk (EuroSCORE) with the EuroSCORE 2 to predict mortality in high-risk cardiac surgery.
  • Laura Guillet
  • Pierre H Moury
  • Damien Bedague
  • Michel Durand
  • Cécile Martin
  • Jean F Payen
  • Olivier Chavanon
  • Pierre Albaladejo
  • Ann Card Anaesth.2020 Jul-Sep;23(3):277-282. AnnCardAnaesth_2020_23_3_277_290043. doi: 10.4103/aca.ACA_209_18.

肝臓でのブドウ糖の利用率が低いと、外因性高コレステロール血症ラットの食事誘発性高コレステロール血症を引き起こす

Low utilization of glucose in the liver causes diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats.
  • Yasutake Tanaka
  • Masahiro Ono
  • Motonori Miyago
  • Takahisa Suzuki
  • Yurika Miyazaki
  • Michio Kawano
  • Makoto Asahina
  • Bungo Shirouchi
  • Katsumi Imaizumi
  • Masao Sato
  • PLoS ONE.2020;15(3):e0229669. PONE-D-19-24869. doi: 10.1371/journal.pone.0229669.Epub 2020-03-12.

1 日 1 回経口投与の新規 5-リポオキシゲナーゼ活性化蛋白質阻害薬 AZD5718 の初期臨床経験

Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5-Lipoxygenase Activating Protein Inhibitor.
  • Hans Ericsson
  • Karin Nelander
  • Maria Lagerstrom-Fermer
  • Clare Balendran
  • Maria Bhat
  • Ligia Chialda
  • Li-Ming Gan
  • Maria Heijer
  • Magnus Kjaer
  • John Lambert
  • Eva-Lotte Lindstedt
  • Gun-Britt Forsberg
  • Carl Whatling
  • Stanko Skrtic
  • Clin Transl Sci.2018 05;11(3):330-338. doi: 10.1111/cts.12546.Epub 2018-03-08.

小さなカエルが長い道のりを飛躍させる：小さな東洋のカエル属（両生類：Microhylidae）で発見されたインド亜大陸の複合的な植民地化

A little frog leaps a long way: compounded colonizations of the Indian Subcontinent discovered in the tiny Oriental frog genus (Amphibia: Microhylidae).
  • Vladislav A Gorin
  • Evgeniya N Solovyeva
  • Mahmudul Hasan
  • Hisanori Okamiya
  • D M S Suranjan Karunarathna
  • Parinya Pawangkhanant
  • Anslem de Silva
  • Watinee Juthong
  • Konstantin D Milto
  • Luan Thanh Nguyen
  • Chatmongkon Suwannapoom
  • Alexander Haas
  • David P Bickford
  • Indraneil Das
  • Nikolay A Poyarkov
  • PeerJ.2020;8:e9411. 9411. doi: 10.7717/peerj.9411.Epub 2020-07-03.

可溶性血管内皮増殖因子受容体-1に対する内皮細胞の接着は、細胞の動態と血管新生の表現型を誘発する

Endothelial cell adhesion to soluble vascular endothelial growth factor receptor-1 triggers a cell dynamic and angiogenic phenotype.
  • Angela Orecchia
  • Amel Mettouchi
  • Paolo Uva
  • Glenn C Simon
  • Diego Arcelli
  • Simona Avitabile
  • Gianluca Ragone
  • Guerrino Meneguzzi
  • Karl H Pfenninger
  • Giovanna Zambruno
  • Cristina Maria Failla
  • FASEB J..2014 Feb;28(2):692-704. fj.12-225771. doi: 10.1096/fj.12-225771.Epub 2013-10-30.

血清性抗リン脂質症候群の診断におけるアネキシンA5抵抗性と非基準抗体の意義

Annexin-A5 resistance and non-criteria antibodies for the diagnosis of seronegative antiphospholipid syndrome.
  • Théo Ghelfenstein Ferreira
  • François Delhommeau
  • Catherine Johanet
  • Grigorios Gerotziafas
  • Marie Bornes
  • Jonathan Cohen
  • Gilles Kayem
  • Olivier Fain
  • Virginie Planche
  • Arsene Mékinian
  • Clin. Rheumatol..2020 Apr;39(4):1167-1171. 10.1007/s10067-019-04915-5. doi: 10.1007/s10067-019-04915-5.Epub 2020-01-10.

胎児の心室セプタムが無傷の肺動脈性心房症に対する胎児心臓インターベンション：国際胎児心臓インターベンション・レジストリ（IFCIR）

Fetal Cardiac Intervention for Pulmonary Atresia with Intact Ventricular Septum: International Fetal Cardiac Intervention Registry.
  • Whitnee J Hogan
  • Sofia Grinenco
  • Aimee Armstrong
  • Roland Devlieger
  • Joanna Dangel
  • Queralt Ferrer
  • Michele Frommelt
  • Alberto Galindo
  • Helena Gardiner
  • Sarah Gelehrter
  • Ulrike Herberg
  • Lisa Howley
  • Edgar Jaeggi
  • Joana Miranda
  • Shaine A Morris
  • Dick Oepkes
  • Simone Pedra
  • Renuka Peterson
  • Gary Sholler
  • John Simpson
  • James Strainic
  • Trisha V Vigneswarran
  • Annette Wacker-Gussmann
  • Anita J Moon-Grady
  • Fetal. Diagn. Ther..2020 Jul;:1-9. 000508045. doi: 10.1159/000508045.Epub 2020-07-07.

アジアのびらん性食道炎患者を対象に、ランソプラゾールと比較したフォノプラザンの有効性と安全性を評価する第Ⅲ相無作為化二重盲検多施設共同試験

Phase III, randomised, double-blind, multicentre study to evaluate the efficacy and safety of vonoprazan compared with lansoprazole in Asian patients with erosive oesophagitis.
  • Yinglian Xiao
  • Shutian Zhang
  • Ning Dai
  • Guijun Fei
  • Khean-Lee Goh
  • Hoon Jai Chun
  • Bor-Shyang Sheu
  • Chui Fung Chong
  • Nobuo Funao
  • Wen Zhou
  • Minhu Chen
  • Gut.2020 02;69(2):224-230. gutjnl-2019-318365. doi: 10.1136/gutjnl-2019-318365.Epub 2019-08-13.

ゲノムワイドなスクリーニングにより、女性の性器管のコロニー化とウイルス性を促進するA群連鎖球菌表面タンパク質が同定された

Genome-Wide Screens Identify Group A Streptococcus Surface Proteins Promoting Female Genital Tract Colonization and Virulence.
  • Luchang Zhu
  • Randall J Olsen
  • Stephen B Beres
  • Matthew Ojeda Saavedra
  • Samantha L Kubiak
  • Concepcion C Cantu
  • Leslie Jenkins
  • Prasanti Yerramilli
  • Layne Pruitt
  • Amelia R L Charbonneau
  • Andrew S Waller
  • James M Musser
  • Am. J. Pathol..2020 04;190(4):862-873. S0002-9440(20)30018-3. doi: 10.1016/j.ajpath.2019.12.003.Epub 2020-03-19.

閉経後出血を伴う女性における主観的パターン認識による子宮内膜癌の超音波診断：プロスペクティブな評価者間の一致度と信頼性に関する研究

Ultrasound diagnosis of endometrial cancer by subjective pattern recognition in women with postmenopausal bleeding: a prospective inter-rater agreement and reliability study.
  • M Wong
  • N Thanatsis
  • T Amin
  • E Bean
  • K Madhvani
  • D Jurkovic
  • Ultrasound Obstet Gynecol.2020 Jul;doi: 10.1002/uog.22141.Epub 2020-07-04.

ヒト胚性幹細胞由来の筋原性前駆細胞から設計された骨格筋構築物は、EGM-2サプリメントを含む培地中で分化したときに拡張された収縮力を展示しています

Skeletal Muscle Constructs Engineered from Human Embryonic Stem Cell Derived Myogenic Progenitors Exhibit Enhanced Contractile Forces When Differentiated in a Medium Containing EGM-2 Supplements.
  • Bin Xu
  • Mengen Zhang
  • Rita C R Perlingeiro
  • Wei Shen
  • Adv Biosyst.2019 Dec;3(12):e1900005. doi: 10.1002/adbi.201900005.Epub 2019-11-04.

メチオニン残基の酸化は、高閾値熱感受性イオンチャネルTRPV2を活性化する

Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2.
  • Tabea C Fricke
  • Frank Echtermeyer
  • Johannes Zielke
  • Jeanne de la Roche
  • Milos R Filipovic
  • Stéphane Claverol
  • Christine Herzog
  • Makoto Tominaga
  • Ruth A Pumroy
  • Vera Y Moiseenkova-Bell
  • Peter M Zygmunt
  • Andreas Leffler
  • Mirjam J Eberhardt
  • Proc. Natl. Acad. Sci. U.S.A..2019 11;116(48):24359-24365. 1904332116. doi: 10.1073/pnas.1904332116.Epub 2019-11-12.

大規模なセーフティネット病院における非定型腺細胞の割合の高さは、疾患の発生率の高さと相関するか？

Do High Rates of Atypical Glandular Cells Correlate With Higher Incidence of Disease in a Large Safety Net Hospital.
  • Theresa Kuhn
  • Catherine Finneran
  • Adrian Kohut
  • Emily Wang
  • George Birdsong
  • Uma Krishnamurti
  • Marina Mosunjac
  • Talaat Tadros
  • Gabriela Oprea
  • Vaidehi Avadhani
  • Shae Boguslawski
  • Samantha Karlow
  • Peter Schnatz
  • Namita Khanna
  • Lisa Flowers
  • J Low Genit Tract Dis.2020 Jun;doi: 10.1097/LGT.0000000000000556.Epub 2020-06-17.

慢性ストレス下での神経血管カップリングはGABA作動性神経細胞間葉系活動の変化によって変化する．

Neurovascular Coupling under Chronic Stress Is Modified by Altered GABAergic Interneuron Activity.
  • Kayoung Han
  • Jiwoong Min
  • Myunghee Lee
  • Bok-Man Kang
  • Taeyoung Park
  • Junghyun Hahn
  • Jaeseung Yei
  • Juheon Lee
  • Junsung Woo
  • C Justin Lee
  • Seong-Gi Kim
  • Minah Suh
  • J. Neurosci..2019 12;39(50):10081-10095. JNEUROSCI.1357-19.2019. doi: 10.1523/JNEUROSCI.1357-19.2019.Epub 2019-10-31.

自然細胞死と細菌性病害抵抗性の向上を示すイネ病巣擬態変異体oshpl3の特性と遺伝学的解析

Characterization and genetic analysis of the oshpl3 rice lesion mimic mutant showing spontaneous cell death and enhanced bacterial blight resistance.
  • Ranran Tu
  • Hong Wang
  • Qunen Liu
  • Dongfei Wang
  • Xingpeng Zhou
  • Peng Xu
  • Yinxing Zhang
  • Weixun Wu
  • Daibo Chen
  • Liyong Cao
  • Shihua Cheng
  • Xihong Shen
  • Plant Physiol. Biochem..2020 May;154:94-104. S0981-9428(20)30215-1. doi: 10.1016/j.plaphy.2020.05.001.Epub 2020-05-08.

ツバ・メラノスポラム（Tuber melanosporum）とツバ・インディカム（Tuber indicum）による植民地化は、根圏におけるマツ・アーマンディ（Pinus armandii）の生育とphoDアルカリホスファターゼをコードする細菌群集に影響を与えることがわかった

Colonization by Tuber melanosporum and Tuber indicum affects the growth of Pinus armandii and phoD alkaline phosphatase encoding bacterial community in the rhizosphere.
  • Xiaoping Zhang
  • Xiaolin Li
  • Lei Ye
  • Yue Huang
  • Zongjing Kang
  • Bo Zhang
  • Xiaoping Zhang
  • Microbiol. Res..2020 Jun;239:126520. S0944-5013(20)30388-8. doi: 10.1016/j.micres.2020.126520.Epub 2020-06-03.

古代のゲノムから明らかになった中国のカシミア生産ヤギの進化の歴史と起源

Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China.
  • Yudong Cai
  • Weiwei Fu
  • Dawei Cai
  • Rasmus Heller
  • Zhuqing Zheng
  • Jia Wen
  • Hui Li
  • Xiaolong Wang
  • Akil Alshawi
  • Zhouyong Sun
  • Siqi Zhu
  • Juan Wang
  • Miaomiao Yang
  • Songmei Hu
  • Yan Li
  • Zhirui Yang
  • Mian Gong
  • Yunan Hou
  • Tianming Lan
  • Kui Wu
  • Yulin Chen
  • Yu Jiang
  • Xihong Wang
  • Mol. Biol. Evol..2020 Jul;37(7):2099-2109. 5824306. doi: 10.1093/molbev/msaa103.

臍帯血移植患者を対象とした移植前播種性フザリヌス菌症の高用量リポソーマルアムホテリシンB投与による治療に成功した

[Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient].
  • Yasuhiko Harada
  • Makoto Murata
  • Akane Matsumoto
  • Daizo Kato
  • Tetsuya Yagi
  • Takashi Yaguchi
  • Takenori Yoshikawa
  • Takuya Takeichi
  • Masashi Akiyama
  • Yohei Yamaguchi
  • Daisuke Koyama
  • Seitaro Terakura
  • Tetsuya Nishida
  • Hitoshi Kiyoi
  • Rinsho Ketsueki.2019;60(12):1641-1646. doi: 10.11406/rinketsu.60.1641.

肺癌に対する新規EGFR L858Rキナーゼ阻害剤としてのルテオリン-7-グルコシドとエピカテキンガレートの同定。ドッキングとシミュレーションに基づく研究

Identification of luteolin -7-glucoside and epicatechin gallate from , as novel EGFR L858R kinase inhibitors against lung cancer: Docking and simulation-based study.
  • Priyanka Maiti
  • Mahesha Nand
  • Tushar Joshi
  • Muthannan Andavar Ramakrishnan
  • Subhash Chandra
  • J. Biomol. Struct. Dyn..2020 Jun;:1-10. doi: 10.1080/07391102.2020.1784791.Epub 2020-06-24.

外傷と出血性ショックで肺組織内の5-リポキシゲナーゼと5-リポキシゲナーゼ活性化蛋白質の分子会合が活性化されることを明らかにした

Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue.
  • Geoffrey R Nunns
  • John R Stringham
  • Fabia Gamboni
  • Ernest E Moore
  • Miguel Fragoso
  • Gregory R Stettler
  • Christopher C Silliman
  • Anirban Banerjee
  • J. Surg. Res..2018 09;229:262-270. S0022-4804(18)30188-4. doi: 10.1016/j.jss.2018.03.023.Epub 2018-05-05.

国の栄養研究の強化：新たに調整された連邦政府の研究努力と権限のための根拠と選択肢

Strengthening national nutrition research: rationale and options for a new coordinated federal research effort and authority.
  • Sheila E Fleischhacker
  • Catherine E Woteki
  • Paul M Coates
  • Van S Hubbard
  • Grace E Flaherty
  • Daniel R Glickman
  • Thomas R Harkin
  • David Kessler
  • William W Li
  • Joseph Loscalzo
  • Anand Parekh
  • Sylvia Rowe
  • Patrick J Stover
  • Angie Tagtow
  • Anthony Joon Yun
  • Dariush Mozaffarian
  • Am. J. Clin. Nutr..2020 Jul;nqaa179. doi: 10.1093/ajcn/nqaa179.Epub 2020-07-20.

アンデスの深層人口史の古生物学的再構築

A Paleogenomic Reconstruction of the Deep Population History of the Andes.
  • Nathan Nakatsuka
  • Iosif Lazaridis
  • Chiara Barbieri
  • Pontus Skoglund
  • Nadin Rohland
  • Swapan Mallick
  • Cosimo Posth
  • Kelly Harkins-Kinkaid
  • Matthew Ferry
  • Éadaoin Harney
  • Megan Michel
  • Kristin Stewardson
  • Jannine Novak-Forst
  • José M Capriles
  • Marta Alfonso Durruty
  • Karina Aranda Álvarez
  • David Beresford-Jones
  • Richard Burger
  • Lauren Cadwallader
  • Ricardo Fujita
  • Johny Isla
  • George Lau
  • Carlos Lémuz Aguirre
  • Steven LeBlanc
  • Sergio Calla Maldonado
  • Frank Meddens
  • Pablo G Messineo
  • Brendan J Culleton
  • Thomas K Harper
  • Jeffrey Quilter
  • Gustavo Politis
  • Kurt Rademaker
  • Markus Reindel
  • Mario Rivera
  • Lucy Salazar
  • José R Sandoval
  • Calogero M Santoro
  • Nahuel Scheifler
  • Vivien Standen
  • Maria Ines Barreto
  • Isabel Flores Espinoza
  • Elsa Tomasto-Cagigao
  • Guido Valverde
  • Douglas J Kennett
  • Alan Cooper
  • Johannes Krause
  • Wolfgang Haak
  • Bastien Llamas
  • David Reich
  • Lars Fehren-Schmitz
  • Cell.2020 May;181(5):1131-1145.e21. S0092-8674(20)30477-3. doi: 10.1016/j.cell.2020.04.015.Epub 2020-05-07.

DNA二本鎖切断部の機能的転写プロモーターがダメージ応答因子のRNA駆動型相分離を媒介している

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors.
  • Fabio Pessina
  • Fabio Giavazzi
  • Yandong Yin
  • Ubaldo Gioia
  • Valerio Vitelli
  • Alessandro Galbiati
  • Sara Barozzi
  • Massimiliano Garre
  • Amanda Oldani
  • Andrew Flaus
  • Roberto Cerbino
  • Dario Parazzoli
  • Eli Rothenberg
  • Fabrizio d'Adda di Fagagna
  • Nat. Cell Biol..2019 10;21(10):1286-1299. 10.1038/s41556-019-0392-4. doi: 10.1038/s41556-019-0392-4.Epub 2019-09-30.

アリールメチルイソシアニドおよびアリールメチルアミンとキサンタートエステルの反応：カルバモチオエートの意外な合成法を提案した

The reaction of arylmethyl isocyanides and arylmethylamines with xanthate esters: a facile and unexpected synthesis of carbamothioates.
  • Narasimhamurthy Rajeev
  • Toreshettahally R Swaroop
  • Ahmad I Alrawashdeh
  • Shofiur Rahman
  • Abdullah Alodhayb
  • Seegehalli M Anil
  • Kuppalli R Kiran
  • Chandra
  • Paris E Georghiou
  • Kanchugarakoppal S Rangappa
  • Maralinganadoddi P Sadashiva
  • Beilstein J Org Chem.2020;16:159-167. doi: 10.3762/bjoc.16.18.Epub 2020-02-03.

繁殖期の開始時に測定された窒素および硫黄の再固定化関連パラメータは、Nおよび/またはS制限供給下で栽培されたナタネ（Brassica napus L.）において、NおよびS施肥を調整するための早期指標となるか？

Do nitrogen- and sulphur-remobilization-related parameters measured at the onset of the reproductive stage provide early indicators to adjust N and S fertilization in oilseed rape (Brassica napus L.) grown under N- and/or S-limiting supplies?
  • Yacine Akmouche
  • Jeanne Cheneby
  • Mickael Lamboeuf
  • Nicolas Elie
  • Anne Laperche
  • Jessica Bertheloot
  • Philippe D'Hooghe
  • Jacques Trouverie
  • Jean-Christophe Avice
  • Philippe Etienne
  • Sophie Brunel-Muguet
  • Planta.2019 Dec;250(6):2047-2062. 10.1007/s00425-019-03284-2. doi: 10.1007/s00425-019-03284-2.Epub 2019-09-25.

Remind Me To Remember.認知症と軽度の認知障害を持つ高齢者のための新しいスマートフォンリマインダーアプリケーションのパイロット研究

Remind Me To Remember: A pilot study of a novel smartphone reminder application for older adults with dementia and mild cognitive impairment.
  • Katherine Hackett
  • Sarah Lehman
  • Ross Divers
  • Matthew Ambrogi
  • Likhon Gomes
  • Chiu C Tan
  • Tania Giovannetti
  • Neuropsychol Rehabil.2020 Jul;:1-29. doi: 10.1080/09602011.2020.1794909.Epub 2020-07-20.

卵母細胞の体外成熟期におけるニコチンアミドの補給は着床前胚の発達能力を向上させる。SIRT1/AKTシグナリングとの潜在的なリンク

Nicotinamide Supplementation during the In Vitro Maturation of Oocytes Improves the Developmental Competence of Preimplantation Embryos: Potential Link to SIRT1/AKT Signaling.
  • Marwa El Sheikh
  • Ahmed Atef Mesalam
  • Muhammad Idrees
  • Tabinda Sidrat
  • Ayman Mesalam
  • Kyeong-Lim Lee
  • Il-Keun Kong
  • Cells.2020 Jun;9(6). E1550. doi: 10.3390/cells9061550.Epub 2020-06-25.

引退した男性エリート・アマチュアレベルのラグビーコードアスリートと非接触アスリートにおけるスポーツ関連の累積傷害と長期的な影響。レトロスペクティブ研究

Cumulative Sport-Related Injuries and Longer Term Impact in Retired Male Elite- and Amateur-Level Rugby Code Athletes and Non-contact Athletes: A Retrospective Study.
  • Karen Hind
  • Natalie Konerth
  • Ian Entwistle
  • Alice Theadom
  • Gwyn Lewis
  • Doug King
  • Paul Chazot
  • Patria Hume
  • Sports Med.2020 Jul;10.1007/s40279-020-01310-y. doi: 10.1007/s40279-020-01310-y.Epub 2020-07-16.

パキスタン産Fabricius属（Lepidoptera: Lepidoptera: Noctuidae: Plusiinae）の最初の記録と分類学的記述

First record and taxonomic description of the genus (Fabricius) (Lepidoptera: Noctuidae: Plusiinae) from Pakistan.
  • Muhammad Sajjad
  • Zahid Mahmood Sarwar
  • Syed Ismat Hussain
  • Syed Muhammad Zaka
  • Qamer Saeed
  • Imran Bodlah
  • Khalid Naveed
  • Tahammal Hussain
  • Muhammad Naveed Aslam
  • Waheed Ali Panhwar
  • Hafiz Arslan Anwaar
  • Khalid Ali Khan
  • Saudi J Biol Sci.2020 May;27(5):1375-1379. S1319-562X(19)30303-1. doi: 10.1016/j.sjbs.2019.12.006.Epub 2019-12-13.

健康なボランティアと再発・難治性急性骨髄性白血病患者におけるキザルチニブの集団薬物動態解析

Population Pharmacokinetic Analysis of Quizartinib in Healthy Volunteers and Patients With Relapsed/Refractory Acute Myeloid Leukemia.
  • Dongwoo Kang
  • Elizabeth Ludwig
  • David Jaworowicz
  • Hannah Huang
  • Jill Fiedler-Kelly
  • Jorge Cortes
  • Siddhartha Ganguly
  • Samer Khaled
  • Alwin Krämer
  • Mark Levis
  • Giovanni Martinelli
  • Alexander Perl
  • Nigel Russell
  • Malaz Abutarif
  • Youngsook Choi
  • Jeanne Mendell
  • Ophelia Yin
  • J Clin Pharmacol.2020 Jun;doi: 10.1002/jcph.1680.Epub 2020-06-29.

サンパウロ州（ブラジル）で分離された臨床株をMALDI-TOF MSおよび分子生物学的手法で同定した初の包括的報告書

First Comprehensive Report of Clinical Strains Isolated in the State of Sao Paulo (Brazil) and Identified by MALDI-TOF MS and Molecular Biology.
  • Mario Henrique Paziani
  • Ludmilla Tonani Carvalho
  • Marcia de Souza Carvalho Melhem
  • Margarete Teresa Gottardo de Almeida
  • Maria Emilia Nadaletto Bonifácio da Silva
  • Roberto Martinez
  • Cledir Santos
  • Marcia Regina von Zeska Kress
  • Microorganisms.2019 Dec;8(1). E66. doi: 10.3390/microorganisms8010066.Epub 2019-12-31.

慢性閉塞性肺疾患における LAMA/LABA 合剤併用療法の有効性と安全性。直接的および間接的な治療比較の系統的レビュー

Efficacy and Safety of LAMA/LABA Fixed-Dose Combination Therapies in Chronic Obstructive Pulmonary Disease: A Systematic Review of Direct and Indirect Treatment Comparisons.
  • John R Hurst
  • Kevin Gruffydd-Jones
  • Mousumi Biswas
  • Deniz Guranlioglu
  • Martin Jenkins
  • Neda Stjepanovic
  • Arushi Bamrara
  • Int J Chron Obstruct Pulmon Dis.2020;15:1529-1543. 230955. doi: 10.2147/COPD.S230955.Epub 2020-07-01.

野生型マウスとCdk5-/-マウスの比較リン酸化プロテオミクスによる脳内新規Cdk5基質の探索

Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice.
  • Erick Contreras-Vallejos
  • Elías Utreras
  • Daniel A Bórquez
  • Michaela Prochazkova
  • Anita Terse
  • Howard Jaffe
  • Andrea Toledo
  • Cristina Arruti
  • Harish C Pant
  • Ashok B Kulkarni
  • Christian González-Billault
  • PLoS ONE.2014;9(3):e90363. PONE-D-13-46666. doi: 10.1371/journal.pone.0090363.Epub 2014-03-21.

Fasが媒介する好中球のアポトーシスは、Bid、Bak、およびBaxによって促進され、Bcl-2およびMcl-1によって阻害される

Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
  • Ben A Croker
  • Joanne A O'Donnell
  • Cameron J Nowell
  • Donald Metcalf
  • Grant Dewson
  • Kirsteen J Campbell
  • Kelly L Rogers
  • Yifang Hu
  • Gordon K Smyth
  • Jian-Guo Zhang
  • Michael White
  • Kurt Lackovic
  • Louise H Cengia
  • Lorraine A O'Reilly
  • Philippe Bouillet
  • Suzanne Cory
  • Andreas Strasser
  • Andrew W Roberts
  • Proc. Natl. Acad. Sci. U.S.A..2011 Aug;108(32):13135-40. 1110358108. doi: 10.1073/pnas.1110358108.Epub 2011-07-18.

モンタニド ISA 50V をアジュバントした六価組換えタンパク質ワクチンの開発と急性トキソプラズマ症に対する保護効果の決定

Development of a hexavalent recombinant protein vaccine adjuvanted with Montanide ISA 50 V and determination of its protective efficacy against acute toxoplasmosis.
  • Esra Atalay Şahar
  • Hüseyin Can
  • Sultan Gülçe İz
  • Aysu Değirmenci Döşkaya
  • Mina Kalantari-Dehaghi
  • Remziye Deveci
  • Adnan Yüksel Gürüz
  • Mert Döşkaya
  • BMC Infect. Dis..2020 Jul;20(1):493. 10.1186/s12879-020-05220-2. doi: 10.1186/s12879-020-05220-2.Epub 2020-07-10.

PINK1-Parkinを介したミトファジーの活性化は、Fuchs社の角膜ジストロフィーにおけるミトコンドリア品質管理タンパク質を劣化させる

Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy.
  • Takashi Miyai
  • Shivakumar Vasanth
  • Geetha Melangath
  • Neha Deshpande
  • Varun Kumar
  • Anne-Sophie Benischke
  • Yuming Chen
  • Marianne O Price
  • Francis W Price
  • Ula V Jurkunas
  • Am. J. Pathol..2019 10;189(10):2061-2076. S0002-9440(19)30653-4. doi: 10.1016/j.ajpath.2019.06.012.Epub 2019-07-27.

アフリカ系アメリカ人男性における理想的な心血管系の健康と自己申告健康、糖尿病、および脂肪率との関連

The association of ideal cardiovascular health with self-reported health, diabetes, and adiposity in African American males.
  • Emmanuela B Aboagye-Mensah
  • Rosevine A Azap
  • James B Odei
  • Darrell M Gray
  • Timiya S Nolan
  • Rana Elgazzar
  • DeVeonne White
  • John Gregory
  • Joshua J Joseph
  • Prev Med Rep.2020 Sep;19:101151. S2211-3355(20)30111-X. doi: 10.1016/j.pmedr.2020.101151.Epub 2020-06-26.

土壌中の低濃度または不溶性のカドミウム化合物に対するハイパーアキュムレータSolanum nigrum L.の強い蓄積能力とそのファイトレメディエーションへの示唆

Strong accumulation capacity of hyperaccumulator Solanum nigrum L. for low or insoluble Cd compounds in soil and its implication for phytoremediation.
  • Xuekai Dou
  • Huiping Dai
  • Lidia Skuza
  • Shuhe Wei
  • Chemosphere.2020 Jul;260:127564. S0045-6535(20)31759-8. doi: 10.1016/j.chemosphere.2020.127564.Epub 2020-07-07.

細胞透過性NEMO結合ドメインペプチドによるNF-κBの標的化は、2型糖尿病性腎症の実験モデルにおけるアルブミン尿と腎病変を改善します

Targeting NF-κB by the Cell-Permeable NEMO-Binding Domain Peptide Improves Albuminuria and Renal Lesions in an Experimental Model of Type 2 Diabetic Nephropathy.
  • Lucas Opazo-Ríos
  • Anita Plaza
  • Yenniffer Sánchez Matus
  • Susana Bernal
  • Laura Lopez-Sanz
  • Luna Jimenez-Castilla
  • Daniel Carpio
  • Alejandra Droguett
  • Sergio Mezzano
  • Jesús Egido
  • Carmen Gomez-Guerrero
  • Int J Mol Sci.2020 Jun;21(12). E4225. doi: 10.3390/ijms21124225.Epub 2020-06-13.

淡水藻類クロレラピレノイドサにおけるイブプロフェンの毒性効果、生体蓄積性、生分解性および不斉選択性に及ぼすナノプラスチックの影響（英文

The influence of nanoplastics on the toxic effects, bioaccumulation, biodegradation and enantioselectivity of ibuprofen in freshwater algae Chlorella pyrenoidosa.
  • Fang Wang
  • Bin Wang
  • Han Qu
  • Wenxing Zhao
  • Lei Duan
  • Yizhe Zhang
  • Yitong Zhou
  • Gang Yu
  • Environ. Pollut..2020 Aug;263(Pt B):114593. S0269-7491(20)30700-4. doi: 10.1016/j.envpol.2020.114593.Epub 2020-04-15.

より速く、より鋭く、より正確に。前臨床試験における自動化されたCluster-FLIMは、生きた細胞や組織におけるセラノスティックスの細胞内運命を直接識別します

Faster, sharper, more precise: Automated Cluster-FLIM in preclinical testing directly identifies the intracellular fate of theranostics in live cells and tissue.
  • Robert Brodwolf
  • Pierre Volz-Rakebrand
  • Johannes Stellmacher
  • Christopher Wolff
  • Michael Unbehauen
  • Rainer Haag
  • Monika Schäfer-Korting
  • Christian Zoschke
  • Ulrike Alexiev
  • Theranostics.2020;10(14):6322-6336. thnov10p6322. doi: 10.7150/thno.42581.Epub 2020-05-15.

ﾌﾟﾛﾊﾞﾝﾄﾞの内視鏡所見から遺伝性びまん性胃癌が強く疑われた2つの独立した家族

Two independent families with strongly suspected hereditary diffuse gastric cancer based on the probands' endoscopic findings.
  • Moriya Iwaizumi
  • Hidetaka Yamada
  • Misaki Fukue
  • Yasuhiko Maruyama
  • Ayano Sonoda
  • Mitsushige Sugimoto
  • Kenji Koda
  • Ryoji Kushima
  • Masato Maekawa
  • Haruhiko Sugimura
  • Clin J Gastroenterol.2020 Jun;10.1007/s12328-020-01163-y. doi: 10.1007/s12328-020-01163-y.Epub 2020-06-27.

HLTFはフォーク反転を促進し、複製ストレス抵抗性を制限し、抑制されないDNA合成の複数のメカニズムを防止する

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis.
  • Gongshi Bai
  • Chames Kermi
  • Henriette Stoy
  • Carl J Schiltz
  • Julien Bacal
  • Angela M Zaino
  • M Kyle Hadden
  • Brandt F Eichman
  • Massimo Lopes
  • Karlene A Cimprich
  • Mol. Cell.2020 Jun;78(6):1237-1251.e7. S1097-2765(20)30273-2. doi: 10.1016/j.molcel.2020.04.031.Epub 2020-05-21.

担子菌とされていた謎の真菌が、現在ではゴマフ科のアホヤニ属に属することが明らかにされた

: an enigmatic fungus, previously considered a basidiomycete, now revealed as an ascomycete member of the Gomphillaceae.
  • Debora Cervieri Guterres
  • Maria do Desterro Mendes Dos Santos
  • Rildo Alexandre Fernandes da Silva
  • Erica Santos do Carmo Souza
  • William Rosa Oliveira Soares
  • Danilo Batista Pinho
  • José Carmine Dianese
  • Mycologia.2020 Jul;:1-18. doi: 10.1080/00275514.2020.1781501.Epub 2020-07-20.

胃食道逆流症の症状を呈する患者に対する現行アルゴリズムの欠点と、最初の診断内視鏡検査にワイヤレスpH検査を追加することの影響。高容量の農村部の逆流防止センターからのデータ

Drawbacks of the Current Algorithm for Patients With Symptoms of Gastroesophageal Reflux Disease and the Impact of Adding Wireless pH Study to the Initial Diagnostic Endoscopy: Data From High-Volume Rural Antireflux Center.
  • Medhat Y Fanous
  • Tyler Hughes
  • Am Surg.2020 May;86(5):422-428. doi: 10.1177/0003134820921181.

Yeら、「Kaposi's Sarcoma-Associated Herpesvirus Induces of Rapid Release of Angiopoietin-2 from Endothelial Cells（カポジ肉腫-Associated Herpesvirus Induces of Angiopoietin-2 from Endothelial Cells）」の訂正

Correction for Ye et al., "Kaposi's Sarcoma-Associated Herpesvirus Induces Rapid Release of Angiopoietin-2 from Endothelial Cells".
  • Feng-Chun Ye
  • Fu-Chun Zhou
  • Stanley Nithianantham
  • Bala Chandran
  • Xiao-Lan Yu
  • Aaron Weinberg
  • Shou-Jiang Gao
  • J. Virol..2020 Jul;94(14). e00596-20. doi: 10.1128/JVI.00596-20.Epub 2020-07-01.

アマツのグリーンプロポリス生産におけるバッカリス・ドラクンチュリフォリアの役割とその化学的プロファイル（英文

The Role of Baccharis dracunculifolia and its Chemical Profile on Green Propolis Production by Apis mellifera.
  • Débora Munhoz Rodrigues
  • Marcelo Claro De Souza
  • Caroline Arruda
  • Rodrigo Augusto Santinelo Pereira
  • Jairo Kenupp Bastos
  • J. Chem. Ecol..2020 Feb;46(2):150-162. 10.1007/s10886-019-01141-w. doi: 10.1007/s10886-019-01141-w.Epub 2019-12-23.

哺乳類のアセテート依存性アセチルCoA合成酵素2の保存ドメインにおける置換変異は、タンパク質の不安定化とHIF-2シグナル伝達の障害をもたらす

A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling.
  • Jason S Nagati
  • Min Xu
  • Trent Garcia
  • Sarah A Comerford
  • Robert E Hammer
  • Joseph A Garcia
  • PLoS ONE.2019;14(11):e0225105. PONE-D-19-05588. doi: 10.1371/journal.pone.0225105.Epub 2019-11-14.

パラメリタンニンA-2は、胃癌細胞において、PI3K/Akt、ERK1/2、p38経路を阻害することにより、ドキソルビシン誘導性ミトコンドリア依存性アポトーシスを促進することが明らかになった

Parameritannin A-2 from Urceola huaitingii enhances doxorubicin-induced mitochondria-dependent apoptosis by inhibiting the PI3K/Akt, ERK1/2 and p38 pathways in gastric cancer cells.
  • Lu Liang
  • Aftab Amin
  • Wing-Yan Cheung
  • Rui Xu
  • Rujian Yu
  • Jinshan Tang
  • Xinsheng Yao
  • Chun Liang
  • Chem. Biol. Interact..2020 Jan;316:108924. S0009-2797(19)31817-4. doi: 10.1016/j.cbi.2019.108924.Epub 2019-12-13.

Pistia stratiotes L. (Araceae)の水中クロマゾン曝露による形態解剖学的損傷

Morphoanatomical injuries in Pistia stratiotes L. (Araceae) as a result of exposure to clomazone in water.
  • Victor Hugo Vidal Ribeiro
  • Ítalo Antônio Cotta Coutinho
  • Brenda Thais Barbalho Alencar
  • Cássia Michelle Cabral
  • José Barbosa Dos Santos
  • Evander Alves Ferreira
  • Dayana Maria Teodoro Francino
  • An. Acad. Bras. Cienc..2020;92 Suppl 1:e20180519. S0001-37652020000201003. doi: 10.1590/0001-3765202020180519.Epub 2020-04-27.

シアリルトランスフェラーゼの阻害は、E-selectin、VCAM1、およびMADCAM1と腫瘍細胞との相互作用の阻害をもたらし、ヒト多発性骨髄腫マウスモデルにおいて生存率を改善する

Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model.
  • Alessandro Natoni
  • Mariah L Farrell
  • Sophie Harris
  • Carolyne Falank
  • Lucy Kirkham-McCarthy
  • Matthew S Macauley
  • Michaela R Reagan
  • Michael O'Dwyer
  • Haematologica.2020;105(2):457-467. haematol.2018.212266. doi: 10.3324/haematol.2018.212266.Epub 2020-01-31.

RNAseqおよび16sアンプリコンシーケンシングによるオクチルフェノール暴露がRana chensinensisオタマジャクシの腸管の脂質代謝およびマイクロバイオームに及ぼす影響（英文

Effects of octylphenol exposure on the lipid metabolism and microbiome of the intestinal tract of Rana chensinensis tadpole by RNAseq and 16s amplicon sequencing.
  • Rong Liu
  • Yuhui Zhang
  • Jinshu Gao
  • Xinyi Li
  • Ecotoxicol. Environ. Saf..2020 Jul;197:110650. S0147-6513(20)30489-9. doi: 10.1016/j.ecoenv.2020.110650.Epub 2020-04-18.

マルチパラメトリックイメージングは、腎臓収集管内のミトコンドリアに富んだインターカレート細胞が非常に高い解糖能力を持っていることを明らかにした

Multiparametric imaging reveals that mitochondria-rich intercalated cells in the kidney collecting duct have a very high glycolytic capacity.
  • Susan Ghazi
  • Soline Bourgeois
  • Alvaro Gomariz
  • Milica Bugarski
  • Dominik Haenni
  • Joana R Martins
  • César Nombela-Arrieta
  • Robert J Unwin
  • Carsten A Wagner
  • Andrew M Hall
  • Eilidh Craigie
  • FASEB J..2020 Jun;34(6):8510-8525. doi: 10.1096/fj.202000273R.Epub 2020-05-04.

台湾人集団におけるインターロイキン-1受容体1型および2型の遺伝的多型と加齢性難聴との関連：症例対照研究

The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study.
  • Ning-Chia Chang
  • Hua-Ling Yang
  • Chia-Yen Dai
  • Wen-Yi Lin
  • Hsun-Mo Wang
  • Chen-Yu Chien
  • Kuen-Yao Ho
  • J Otolaryngol Head Neck Surg.2020 Apr;49(1):16. 10.1186/s40463-020-00410-z. doi: 10.1186/s40463-020-00410-z.Epub 2020-04-06.

ロングノンコーディングRNA（lncRNA）小核球RNA宿主遺伝子15（SNHG15）は、細胞外マトリックスのホメオスタシスを制御することで変形性関節症の進行を緩和する

Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 15 (SNHG15) Alleviates Osteoarthritis Progression by Regulation of Extracellular Matrix Homeostasis.
  • Yunping Chen
  • Hongna Guo
  • Lang Li
  • Dingsu Bao
  • Feng Gao
  • Qiang Li
  • Qi Huang
  • Xin Duan
  • Zhou Xiang
  • Med. Sci. Monit..2020 Jul;26:e923868. 923868. doi: 10.12659/MSM.923868.Epub 2020-07-09.

抗糖尿病成分であるシクロアルテノールと24-メチレンシクロアルタノールは、フィカス・クリシュナエから抽出されたものです

Antidiabetes constituents, cycloartenol and 24-methylenecycloartanol, from Ficus krishnae.
  • Ajikumaran Nair Sadasivan Nair
  • Reshma Vijayakumari Raveendran Nair
  • Aroma Prasanna Rajendran Nair
  • Akhila Sasikumar Nair
  • Sabu Thyagarajan
  • Anil John Johnson
  • Sabulal Baby
  • PLoS ONE.2020;15(6):e0235221. PONE-D-20-02022. doi: 10.1371/journal.pone.0235221.Epub 2020-06-25.

高分解能都市汚染マッピングのための移動式黒炭素測定と固定式黒炭素測定の比較

Comparison of Mobile and Fixed-Site Black Carbon Measurements for High-Resolution Urban Pollution Mapping.
  • Sarah E Chambliss
  • Chelsea V Preble
  • Julien J Caubel
  • Troy Cados
  • Kyle P Messier
  • Ramón A Alvarez
  • Brian LaFranchi
  • Melissa Lunden
  • Julian D Marshall
  • Adam A Szpiro
  • Thomas W Kirchstetter
  • Joshua S Apte
  • Environ. Sci. Technol..2020 Jul;54(13):7848-7857. doi: 10.1021/acs.est.0c01409.Epub 2020-06-24.

ハプロ同一性造血幹細胞移植後の血液悪性腫瘍患者におけるエプスタインバーウイルス感染症および移植片対宿主病に対するATG-チモグロブリンとATG-フレゼニウスの比較：単一施設での経験

Comparison of ATG-thymoglobulin with ATG-Fresenius for Epstein-Barr virus infections and graft-versus-host-disease in patients with hematological malignances after haploidentical hematopoietic stem cell transplantation: a single-center experience.
  • Ling Zhou
  • Zhi-Yong Gao
  • Dao-Pei Lu
  • Ann. Hematol..2020 Jun;99(6):1389-1400. 10.1007/s00277-020-04014-5. doi: 10.1007/s00277-020-04014-5.Epub 2020-04-14.

可視光照射下でのシゲラ菌の園内光触媒的殺菌。その分子機構、抗菌抵抗性、バイオフィルム形成への洞察

Sonophotocatalytic disinfection of Shigella species under visible light irradiation: Insights into its molecular mechanism, antibacterial resistance and biofilm formation.
  • A P Habeeb Rahman
  • Swagatika Dash
  • Priti Sundar Mohanty
  • Amrita Mishra
  • Cecilia Stålsby Lundborg
  • Suraj K Tripathy
  • Environ. Res..2020 Aug;187:109620. S0013-9351(20)30513-2. doi: 10.1016/j.envres.2020.109620.Epub 2020-05-08.

新規コロナウイルス2019-nCoVの迅速な生物学的解析のための情報スペクトル法の使用：潜在的な受容体、天然リザーバー、トロピズム、治療/ワクチンターゲットの予測

Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
  • Veljko Veljkovic
  • Júlia Vergara-Alert
  • Joaquim Segalés
  • Slobodan Paessler
  • F1000Res.2020;9:52. doi: 10.12688/f1000research.22149.3.Epub 2020-01-27.

二尖弁再移植による大動脈根置換術。転帰や弁の耐久性は三尖弁再植術と同等か？

Aortic root replacement with bicuspid valve reimplantation: Are outcomes and valve durability comparable to those of tricuspid valve reimplantation?
  • Suyog A Mokashi
  • Brad F Rosinski
  • Milind Y Desai
  • Brian P Griffin
  • Donald F Hammer
  • Vidyasagar Kalahasti
  • Douglas R Johnston
  • Jeevanantham Rajeswaran
  • Eric E Roselli
  • Eugene H Blackstone
  • Lars G Svensson
  • J. Thorac. Cardiovasc. Surg..2020 May;S0022-5223(20)31091-6. doi: 10.1016/j.jtcvs.2020.02.147.Epub 2020-05-11.

重度のセリン生合成障害の遺伝子型と表現型のスペクトルを拡大する

Expanding the genotypic and phenotypic spectrum of severe serine biosynthesis disorders.
  • Fatima Abdelfattah
  • Ariana Kariminejad
  • Anne-Karin Kahlert
  • Patrick J Morrison
  • Evren Gumus
  • Katherine D Mathews
  • Benjamin W Darbro
  • David J Amor
  • Maie Walsh
  • Yves Sznajer
  • Luisa Weiß
  • Sabine Weidensee
  • David Chitayat
  • Patrick Shannon
  • Eva Bermejo-Sánchez
  • Isolina Riaño-Galán
  • Ian Hayes
  • Gemma Poke
  • Caroline Rooryck
  • Perrine Pennamen
  • Suonavy Khung-Savatovsky
  • Annick Toutain
  • Marie-Laure Vuillaume
  • Siavash Ghaderi-Sohi
  • Mohamad H Kariminejad
  • Sönke Weinert
  • Heinrich Sticht
  • Martin Zenker
  • Denny Schanze
  • Hum. Mutat..2020 Jun;doi: 10.1002/humu.24067.Epub 2020-06-24.

ブラジル北東部の半乾燥地域における残留殺虫剤散布後のTriatoma brasiliensisによる家屋侵入の迅速な回復

Fast recovery of house infestation with Triatoma brasiliensis after residual insecticide spraying in a semiarid region of Northeastern Brazil.
  • Claudia Mendonça Bezerra
  • Silvia Ermelinda Barbosa
  • Rita de Cássia Moreira de Souza
  • Levi Ximenes Feijão
  • Ricardo Esteban Gürtler
  • Alberto Novaes Ramos
  • Liléia Diotaiuti
  • PLoS Negl Trop Dis.2020 Jul;14(7):e0008404. PNTD-D-19-01607. doi: 10.1371/journal.pntd.0008404.Epub 2020-07-20.

移植後のシクロホスファミドと抗甲状腺グロブリンの併用による移植片対宿主病予防は、高齢の同種造血細胞移植を受けた患者の生存率を向上させ、非再発死亡率を低下させます

Post-transplant cyclophosphamide combined with anti-thymocyte globulin for graft-vs-host disease prophylaxis improves survival and lowers non-relapse mortality in older patients undergoing allogeneic hematopoietic cell transplantation.
  • Ivan Pasic
  • Jeffrey H Lipton
  • Dennis D Kim
  • Auro Viswabandya
  • Rajat Kumar
  • Wilson Lam
  • Arjun D Law
  • Jonas Mattsson
  • Fotios V Michelis
  • Ann. Hematol..2020 Jun;99(6):1377-1387. 10.1007/s00277-020-04033-2. doi: 10.1007/s00277-020-04033-2.Epub 2020-05-07.

"自分がやるとしたら、どのように体験するだろうか？" 死に方支援の領域における薬剤師の実践を探るための理論的枠組みを開発する

"If I were to do this, how would I experience it?" developing a theoretical framework for exploring pharmacists' practice in the domain of assisted dying.
  • Phillip Woods
  • Michelle A King
  • Amary Mey
  • Theresa J Schindel
  • Res Social Adm Pharm.2020 Jun;S1551-7411(19)31196-9. doi: 10.1016/j.sapharm.2020.05.028.Epub 2020-06-02.

母体の既往歴、生化学的マーカー、子宮動脈ドップラーを用いた早期発症前子癇症のガウシアン第一期スクリーニングのカットオフ値

Cut-off values for Gaussian first-trimester screening for early-onset preeclampsia with maternal history, biochemical markers and uterine artery Doppler.
  • Manel Mendoza
  • Helena Tur
  • Pablo Garcia-Manau
  • Ivan Hurtado
  • Berta Serrano
  • Rosa Maria Lopez-Martinez
  • Laura Castellote
  • Luisa Martinez
  • Erika Bonacina
  • Elena Carreras
  • J Gynecol Obstet Hum Reprod.2020 Jun;:101827. S2468-7847(20)30171-9. doi: 10.1016/j.jogoh.2020.101827.Epub 2020-06-05.

Xq27.3-q28欠失女性患者からの誘導多能性幹細胞の作製による疾患モデルの確立と治療法の特定

Generation of Induced Pluripotent Stem Cells from a Female Patient with a Xq27.3-q28 Deletion to Establish Disease Models and Identify Therapies.
  • Noriko Watanabe
  • Kohei Kitada
  • Katherine E Santostefano
  • Airi Yokoyama
  • Sara M Waldrop
  • Coy D Heldermon
  • Daisuke Tachibana
  • Masayasu Koyama
  • Amy M Meacham
  • Christina A Pacak
  • Naohiro Terada
  • Cell Reprogram.2020 Jun;doi: 10.1089/cell.2020.0012.Epub 2020-06-30.

健康な仔馬への単回投与および多回投与後のガミスロマイシンとリファンピシンの薬物動態相互作用に対する腸および肝臓の寄与

Intestinal and hepatic contributions to the pharmacokinetic interaction between gamithromycin and rifampicin after single-dose and multiple-dose administration in healthy foals.
  • S Berlin
  • S Wallstabe
  • E Scheuch
  • S Oswald
  • M Hasan
  • D Wegner
  • M Grube
  • M Venner
  • A Ullrich
  • W Siegmund
  • Equine Vet. J..2018 Jul;50(4):525-531. doi: 10.1111/evj.12796.Epub 2018-01-08.

Ｈ核磁気共鳴分光法は、より大きな振幅の高速運動と、発火性ｐＨでのβシートヒト免疫不全ウイルスｇｐ４１融合ペプチドまたはヘリカルヘアピンインフルエンザウイルスヘマグルチニン融合ペプチドを含む膜のための脂質鎖秩序との干渉を支持する

H nuclear magnetic resonance spectroscopy supports larger amplitude fast motion and interference with lipid chain ordering for membrane that contains β sheet human immunodeficiency virus gp41 fusion peptide or helical hairpin influenza virus hemagglutinin fusion peptide at fusogenic pH.
  • Ujjayini Ghosh
  • David P Weliky
  • Biochim Biophys Acta Biomembr.2020 Jun;1862(10):183404. S0005-2736(20)30246-7. doi: 10.1016/j.bbamem.2020.183404.Epub 2020-06-23.

高リスクの三尖静脈逆流症患者におけるLuX弁を用いた経カテーテル三尖静脈弁置換術のファースト・イン・マンの経験

First-in-Man Experience of Transcatheter Tricuspid Valve Replacement With LuX-Valve in High-Risk Tricuspid Regurgitation Patients.
  • Fang-Lin Lu
  • Ye Ma
  • Zhao An
  • Cheng-Liang Cai
  • Bai-Ling Li
  • Zhi-Gang Song
  • Lin Han
  • Jun Wang
  • Fan Qiao
  • Zhi-Yun Xu
  • JACC Cardiovasc Interv.2020 Jul;13(13):1614-1616. S1936-8798(20)30810-4. doi: 10.1016/j.jcin.2020.03.026.

コウモリのミヨチス（Myotis davidii）由来インターフェロン刺激遺伝子産物15（ISG15）の構造とドメイン間のISG15相互作用がウイルスタンパク質のエンゲージメントに与える影響

Structure of interferon-stimulated gene product 15 (ISG15) from the bat species Myotis davidii and the impact of interdomain ISG15 interactions on viral protein engagement.
  • Caroline Langley
  • Octavia Goodwin
  • John V Dzimianski
  • Courtney M Daczkowski
  • Scott D Pegan
  • Acta Crystallogr D Struct Biol.2019 Jan;75(Pt 1):21-31. S2059798318015322. doi: 10.1107/S2059798318015322.Epub 2019-01-04.

擬制クラスレート構造を安定化させた新規ハイドロキノン-アルミナ複合材料の開発。ガス処理への応用

Novel Hydroquinone-Alumina Composites Stabilizing a Guest-Free Clathrate Structure: Applications in Gas Processing.
  • Romuald Coupan
  • Peter Moonen
  • Christophe Dicharry
  • Frederic Plantier
  • Joseph Diaz
  • Eve Péré
  • Abdel Khoukh
  • Fabrice Guerton
  • Pascale Senechal
  • Cédric Charvillat
  • Marie-Line DE Solan
  • Jean-Philippe Torré
  • ACS Appl Mater Interfaces.2020 Jul;doi: 10.1021/acsami.0c06187.Epub 2020-07-07.

経鼻百日咳ワクチンBPZE1の安全性と免疫原性：第1b相、二重盲検、無作為化、プラセボ対照用量漸増試験

Safety and immunogenicity of the live attenuated intranasal pertussis vaccine BPZE1: a phase 1b, double-blind, randomised, placebo-controlled dose-escalation study.
  • Maja Jahnmatz
  • Laura Richert
  • Nabil Al-Tawil
  • Jann Storsaeter
  • Céline Colin
  • Claire Bauduin
  • Marcel Thalen
  • Ken Solovay
  • Keith Rubin
  • Nathalie Mielcarek
  • Rigmor Thorstensson
  • Camille Locht
  • Lancet Infect Dis.2020 Jul;S1473-3099(20)30274-7. doi: 10.1016/S1473-3099(20)30274-7.Epub 2020-07-17.

アフリカのキャッサバの遺伝子形質における光合成は、定常状態ではルビスコとメソフィルのコンダクタンスによって制限されているが、変動する光の中では気孔コンダクタンスによって制限されている

Photosynthesis across African cassava germplasm is limited by Rubisco and mesophyll conductance at steady state, but by stomatal conductance in fluctuating light.
  • Amanda P De Souza
  • Yu Wang
  • Douglas J Orr
  • Elizabete Carmo-Silva
  • Stephen P Long
  • New Phytol..2020 03;225(6):2498-2512. doi: 10.1111/nph.16142.Epub 2019-10-01.

ケトするか、ケトしないか？アルツハイマー病のケトジェニック療法の効果を評価する無作為化対照試験のシステマティックレビュー

To Keto or Not to Keto? A Systematic Review of Randomized Controlled Trials Assessing the Effects of Ketogenic Therapy on Alzheimer Disease.
  • Maria G Grammatikopoulou
  • Dimitrios G Goulis
  • Konstantinos Gkiouras
  • Xenophon Theodoridis
  • Kalliopi K Gkouskou
  • Athanasios Evangeliou
  • Efthimis Dardiotis
  • Dimitrios P Bogdanos
  • Adv Nutr.2020 Jun;nmaa073. doi: 10.1093/advances/nmaa073.Epub 2020-06-29.

10～47年間の歯周維持期間中の歯周炎関連歯喪失に対する喫煙と禁煙の用量依存的効果--適合コホートにおけるレトロスペクティブ研究

Dose-dependent effect of smoking and smoking cessation on periodontitis-related tooth loss during 10 - 47 years periodontal maintenance -- a retrospective study in compliant cohort.
  • Andrea Ravidà
  • Giuseppe Troiano
  • Musa Qazi
  • Muhammad H A Saleh
  • Islam Saleh
  • Wenche S Borgnakke
  • Hom-Lay Wang
  • J. Clin. Periodontol..2020 Jun;doi: 10.1111/jcpe.13336.Epub 2020-06-27.

変異型p53の再活性化と銅結合の減少を伴う亜鉛メタロシャペロンのコンビナトリアル治療

Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding.
  • Saif Zaman
  • Xin Yu
  • Anthony F Bencivenga
  • Adam R Blanden
  • Yue Liu
  • Tracy Withers
  • Bing Na
  • Alan J Blayney
  • John Gilleran
  • David A Boothman
  • Stewart N Loh
  • S David Kimball
  • Darren R Carpizo
  • Mol. Cancer Ther..2019 08;18(8):1355-1365. 1535-7163.MCT-18-1080. doi: 10.1158/1535-7163.MCT-18-1080.Epub 2019-06-13.

BHA, BHT, TBHQを添加したポリプロピレンベースの活性型食品包装フィルムのマイグレーション分析、酸化防止剤、機械的特性の評価

Migration analysis, antioxidant, and mechanical characterization of polypropylene-based active food packaging films loaded with BHA, BHT, and TBHQ.
  • Seyedeh Homa Fasihnia
  • Seyed Hadi Peighambardoust
  • Seyed Jamaleddin Peighambardoust
  • Abdulrasoul Oromiehie
  • Maral Soltanzadeh
  • Donatella Peressini
  • J. Food Sci..2020 Jul;doi: 10.1111/1750-3841.15337.Epub 2020-07-19.

非線形光学顕微鏡は、弾性線維性仮性黄色腫の皮膚変化を解析するための新しいツールである

Nonlinear optical microscopy is a novel tool for the analysis of cutaneous alterations in pseudoxanthoma elasticum.
  • Norbert Kiss
  • Luca Fésűs
  • Szabolcs Bozsányi
  • Flóra Szeri
  • Matthias Van Gils
  • Viktória Szabó
  • Anikó Ilona Nagy
  • Bernadett Hidvégi
  • Róbert Szipőcs
  • Ludovic Martin
  • Olivier Vanakker
  • Tamás Arányi
  • Béla Merkely
  • Norbert M Wikonkál
  • Márta Medvecz
  • Lasers Med Sci.2020 May;10.1007/s10103-020-03027-w. doi: 10.1007/s10103-020-03027-w.Epub 2020-05-06.

上皮-インターロイキン-1は気道線維芽細胞によるコラーゲン形成を阻害する。喘息への示唆

Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma.
  • Emmanuel T Osei
  • Leila B Mostaço-Guidolin
  • Aileen Hsieh
  • Stephanie M Warner
  • May Al-Fouadi
  • Mary Wang
  • Darren J Cole
  • Geoffrey N Maksym
  • Teal S Hallstrand
  • Wim Timens
  • Corry-Anke Brandsma
  • Irene H Heijink
  • Tillie-Louise Hackett
  • Sci Rep.2020 May;10(1):8721. 10.1038/s41598-020-65567-z. doi: 10.1038/s41598-020-65567-z.Epub 2020-05-26.

三塩化第二鉄及び石灰の代替としての有機高分子凝集剤の埋立汚泥の高度脱水・コンディショニングへの適用。そのメカニズム，最適化，パイロットスケールでの検討を行った．

Applying organic polymer flocculants in conditioning and advanced dewatering of landfill sludge as a substitution of ferric trichloride and lime: Mechanism, optimization and pilot-scale study.
  • Xiaodan Zhao
  • Jie Jiang
  • Zhen Zhou
  • Jiazhe Yang
  • Guang Chen
  • Wei Wu
  • Dongqi Sun
  • Jie Yao
  • Zhan Qiu
  • Kankan He
  • Zhichao Wu
  • Ziyang Lou
  • Chemosphere.2020 Jul;260:127617. S0045-6535(20)31812-9. doi: 10.1016/j.chemosphere.2020.127617.Epub 2020-07-11.

複数の遺伝子発現オムニバスデータセットを系統的に解析することで、B型肝炎ウイルス関連急性肝不全における激しい免疫応答が明らかになった

Systematic analysis on multiple Gene Expression Omnibus data sets reveals fierce immune response in hepatitis B virus-related acute liver failure.
  • Huadi Chen
  • Wenting Zhao
  • Yixi Zhang
  • Yiwen Guo
  • Weixin Luo
  • Xiaobo Wang
  • Yu Nie
  • Maodong Ye
  • Changjun Huang
  • Dongping Wang
  • Maogen Chen
  • Xiaoshun He
  • Qiang Zhao
  • J. Cell. Mol. Med..2020 Jul;doi: 10.1111/jcmm.15561.Epub 2020-07-19.

H3K9me3を介したマウスの老化のエピジェネティック制御はリンパ腫患者の転帰を予測する

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
  • Kolja Schleich
  • Julia Kase
  • Jan R Dörr
  • Saskia Trescher
  • Animesh Bhattacharya
  • Yong Yu
  • Elizabeth M Wailes
  • Dorothy N Y Fan
  • Philipp Lohneis
  • Maja Milanovic
  • Andrea Lau
  • Dido Lenze
  • Michael Hummel
  • Bjoern Chapuy
  • Ulf Leser
  • Maurice Reimann
  • Soyoung Lee
  • Clemens A Schmitt
  • Nat Commun.2020 Jul;11(1):3651. 10.1038/s41467-020-17467-z. doi: 10.1038/s41467-020-17467-z.Epub 2020-07-20.

腸内マイクロバイオームトランスファー、COVID-19誘発性高炎症の新規治療戦略？In reply to, 'COVID-19.免疫学および治療オプション」、フェルゼンシュタイン、ハーバート・マクナマラら、２０２０'

Intestinal microbiome transfer, a novel therapeutic strategy for COVID-19 induced hyperinflammation?: In reply to, 'COVID-19: Immunology and treatment options', Felsenstein, Herbert McNamara et al. 2020'.
  • James R McIlroy
  • Benjamin H Mullish
  • Simon D Goldenberg
  • Gianluca Ianiro
  • Julian R Marchesi
  • Clin. Immunol..2020 Jul;218:108542. S1521-6616(20)30439-3. doi: 10.1016/j.clim.2020.108542.Epub 2020-07-12.

転移性甲状腺癌患者の転帰について、組換えTSHと内因性TSHを使用した場合の差は認められなかった

No difference in the outcome of metastatic thyroid cancer patients when using recombinant or endogenous TSH.
  • Maria Cristina Campopiano
  • Debora Podestà
  • Francesca Bianchi
  • Carlotta Giani
  • Laura Agate
  • Valeria Bottici
  • Virginia Cappagli
  • Loredana Lorusso
  • Antonio Matrone
  • Luciana Puleo
  • Laura Valerio
  • David Viola
  • Paolo Piaggi
  • Rossella Elisei
  • Eleonora Molinaro
  • Eur. J. Endocrinol..2020 Jul;EJE-20-0088.R2. doi: 10.1530/EJE-20-0088.Epub 2020-07-01.

ヨルダンにおけるC型肝炎ウイルス遺伝子型分布の最新情報：アンマンの第三次医療教育病院からの12年間のレトロスペクティブ研究

An update on hepatitis C virus genotype distribution in Jordan: a 12-year retrospective study from a tertiary care teaching hospital in Amman.
  • Malik Sallam
  • Rawan Batarseh
  • Anas Natsheh
  • Jumana Abbadi
  • Esraa Al-Fraihat
  • Alaa' Yaseen
  • Doaa Kaddomi
  • Nadia Khamees
  • Azmi Mahafzah
  • Gülşen Özkaya Şahin
  • BMC Infect. Dis..2019 Dec;20(1):3. 10.1186/s12879-019-4735-3. doi: 10.1186/s12879-019-4735-3.Epub 2019-12-31.

神経切除と冬眠がマーモット（Marmota flaviventris）の骨の性質とエンドカンナビノイド系に及ぼす影響

The effects of neurectomy and hibernation on bone properties and the endocannabinoid system in marmots (Marmota flaviventris).
  • Emily M Cravens
  • Jay S Kirkwood
  • Lisa M Wolfe
  • Rebecca A Packer
  • Lawrence R Whalen
  • Samantha J Wojda
  • Jessica E Prenni
  • Gregory L Florant
  • Seth W Donahue
  • Comp. Biochem. Physiol., Part A Mol. Integr. Physiol..2020 03;241:110621. S1095-6433(19)30385-X. doi: 10.1016/j.cbpa.2019.110621.Epub 2019-11-27.

ポリ（ADP-リボシル化）はマウス坐骨神経線維に存在し、シャルコー・マリー・トゥース1E神経変性モデルでは変化しています

Poly(ADP-ribosylation) is present in murine sciatic nerve fibers and is altered in a Charcot-Marie-Tooth-1E neurodegenerative model.
  • Laura I Lafon Hughes
  • Carlos J Romeo Cardeillac
  • Karina B Cal Castillo
  • Salomé C Vilchez Larrea
  • José R Sotelo Sosa
  • Gustavo A Folle Ungo
  • Silvia H Fernández Villamil
  • Alejandra E Kun González
  • PeerJ.2017;5:e3318. 3318. doi: 10.7717/peerj.3318.Epub 2017-05-10.

視神経圧迫動物モデルにおける血管内皮成長因子の役割の違いを介して低酸素環境下でのプラセンタ由来間葉系幹細胞が視神経軸索を救う

Hypoxia-Preconditioned Placenta-Derived Mesenchymal Stem Cells Rescue Optic Nerve Axons Via Differential Roles of Vascular Endothelial Growth Factor in an Optic Nerve Compression Animal Model.
  • Heejung Kwon
  • Mira Park
  • Sarmila Nepali
  • Helen Lew
  • Mol. Neurobiol..2020 Aug;57(8):3362-3375. 10.1007/s12035-020-01965-8. doi: 10.1007/s12035-020-01965-8.Epub 2020-06-10.

プロスタグランジンD-GPR44/DP2軸の阻害は、ヒト膵島の生存と機能を改善する

Inhibition of the prostaglandin D-GPR44/DP2 axis improves human islet survival and function.
  • Shadab Abadpour
  • Björn Tyrberg
  • Simen W Schive
  • Charlotte Wennberg Huldt
  • Peter Gennemark
  • Erik Ryberg
  • Tina Rydén-Bergsten
  • David M Smith
  • Olle Korsgren
  • Stanko Skrtic
  • Hanne Scholz
  • Maria Sörhede Winzell
  • Diabetologia.2020 Jul;63(7):1355-1367. 10.1007/s00125-020-05138-z. doi: 10.1007/s00125-020-05138-z.Epub 2020-04-29.

メトトレキサートに対する反応が不十分な関節リウマチ患者におけるバリシチニブと他の治療の有効性を比較するためのネットワークメタアナリシス

A Network Meta-Analysis to Compare Effectiveness of Baricitinib and Other Treatments in Rheumatoid Arthritis Patients with Inadequate Response to Methotrexate.
  • Walid Fakhouri
  • Xiaofei Wang
  • Inmaculada de La Torre
  • Claudia Nicolay
  • J Health Econ Outcomes Res.2020;7(1):10-23. jheor-7-1-12273. doi: 10.36469/jheor.2020.12273.Epub 2020-04-10.

重症筋無力症患者のCD4 T細胞は、IL-21、IL-4、IL-17Aの産生が増加し、PD-1とICOSの存在が高いことが特徴である

CD4 T Cells of Myasthenia Gravis Patients Are Characterized by Increased IL-21, IL-4, and IL-17A Productions and Higher Presence of PD-1 and ICOS.
  • Merve Çebi
  • Hacer Durmus
  • Fikret Aysal
  • Berker Özkan
  • Gizem Engin Gül
  • Arman Çakar
  • Mehmet Hocaoglu
  • Metin Mercan
  • Sibel P Yentür
  • Melih Tütüncü
  • Vildan Yayla
  • Onur Akan
  • Öner Dogan
  • Yeşim Parman
  • Güher Saruhan-Direskeneli
  • Front Immunol.2020;11:809. doi: 10.3389/fimmu.2020.00809.Epub 2020-05-19.

アネキシンA2の枯渇は、急性リケッチアおよびエボラウイルス感染によって誘発される脳内微小出血を悪化させる

Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections.
  • Zhengchen Su
  • Qing Chang
  • Aleksandra Drelich
  • Thomas Shelite
  • Barbara Judy
  • Yakun Liu
  • Jie Xiao
  • Changchen Zhou
  • Xi He
  • Yang Jin
  • Tais Saito
  • Shaojun Tang
  • Lynn Soong
  • Maki Wakamiya
  • Xiang Fang
  • Alexander Bukreyev
  • Thomas Ksiazek
  • William K Russell
  • Bin Gong
  • PLoS Negl Trop Dis.2020 Jul;14(7):e0007960. PNTD-D-19-01978. doi: 10.1371/journal.pntd.0007960.Epub 2020-07-20.

キノキサリン-7-カルボキシレート1,4-ジ-N-オキサイドのE. histolyticaに対する生物学的活性とチオレドキシン還元酵素阻害剤としての分析

Biological activity of esters of quinoxaline-7-carboxylate 1,4-di-N-oxide against E. histolytica and their analysis as potential thioredoxin reductase inhibitors.
  • Jacqueline Soto-Sánchez
  • Luis A Caro-Gómez
  • Alma D Paz-González
  • Laurence A Marchat
  • Gildardo Rivera
  • Rosa Moo-Puc
  • Diego G Arias
  • Esther Ramírez-Moreno
  • Parasitol. Res..2020 Feb;119(2):695-711. 10.1007/s00436-019-06580-8. doi: 10.1007/s00436-019-06580-8.Epub 2020-01-06.

Salivary Scavenger and Agglutinin (SALSA) Is Expressed in Mucosal Epithelial Cells and Decreased in Bronchial Epitheum of Asthmatic Horses（唾液スカベンジャーとアグルチニン（SALSA）は粘膜上皮細胞で発現し、喘息馬の気管支上皮で減少しています

Salivary Scavenger and Agglutinin (SALSA) Is Expressed in Mucosal Epithelial Cells and Decreased in Bronchial Epithelium of Asthmatic Horses.
  • Gary Kwok Cheong Lee
  • Laurence Tessier
  • Dorothee Bienzle
  • Front Vet Sci.2019;6:418. doi: 10.3389/fvets.2019.00418.Epub 2019-11-29.

スペインで一般的に消費されている地中海および北東大西洋の魚類に見られるアニサキス種とヒステロチラシ種。疫学的、分子的、形態学的判別分析

Anisakis and Hysterothylacium species in Mediterranean and North-East Atlantic fishes commonly consumed in Spain: Epidemiological, molecular and morphometric discriminant analysis.
  • Xavier Roca-Geronès
  • Matías Segovia
  • Carla Godínez-González
  • Roser Fisa
  • Isabel Montoliu
  • Int. J. Food Microbiol..2020 Jul;325:108642. S0168-1605(20)30136-7. doi: 10.1016/j.ijfoodmicro.2020.108642.Epub 2020-04-15.

第三次医療機関におけるパンデミック対策のための迅速な対応インフラ：2020年2月～3月にドイツ・ケルンで発生したCOVID-19アウトブレイクから得られた教訓

Rapid response infrastructure for pandemic preparedness in a tertiary care hospital: lessons learned from the COVID-19 outbreak in Cologne, Germany, February to March 2020.
  • Max Augustin
  • Philipp Schommers
  • Isabelle Suárez
  • Philipp Koehler
  • Henning Gruell
  • Florian Klein
  • Christian Maurer
  • Petra Langerbeins
  • Vanessa Priesner
  • Kirsten Schmidt-Hellerau
  • Jakob J Malin
  • Melanie Stecher
  • Norma Jung
  • Gerhard Wiesmüller
  • Arne Meissner
  • Janine Zweigner
  • Georg Langebartels
  • Felix Kolibay
  • Victor Suárez
  • Volker Burst
  • Philippe Valentin
  • Dirk Schedler
  • Oliver A Cornely
  • Michael Hallek
  • Gerd Fätkenheuer
  • Jan Rybniker
  • Clara Lehmann
  • Euro Surveill..2020 05;25(21). doi: 10.2807/1560-7917.ES.2020.25.21.2000531.

Oxford Nanopore PromethIONシーケンシングとHi-C技術を用いた、アオカワカワヒメジ（Thamnaconus septentrionalis）の染色体レベルでのゲノムアセンブリー

Chromosome-level genome assembly of the greenfin horse-faced filefish (Thamnaconus septentrionalis) using Oxford Nanopore PromethION sequencing and Hi-C technology.
  • Li Bian
  • Fenghui Li
  • Jianlong Ge
  • Pengfei Wang
  • Qing Chang
  • Shengnong Zhang
  • Jie Li
  • Changlin Liu
  • Kun Liu
  • Xintian Liu
  • Xuming Li
  • Hongju Chen
  • Siqing Chen
  • Changwei Shao
  • Zhishu Lin
  • Mol Ecol Resour.2020 May;doi: 10.1111/1755-0998.13183.Epub 2020-05-10.

イースタンウッドチャック（ ）のゲノム配列 - B型慢性肝炎の前臨床モデル動物

The Genome Sequence of the Eastern Woodchuck () - A Preclinical Animal Model for Chronic Hepatitis B.
  • Tyler S Alioto
  • Fernando Cruz
  • Jèssica Gómez-Garrido
  • Miriam Triyatni
  • Marta Gut
  • Leonor Frias
  • Anna Esteve-Codina
  • Stephan Menne
  • Anna Kiialainen
  • Nadine Kumpesa
  • Fabian Birzele
  • Roland Schmucki
  • Ivo G Gut
  • Olivia Spleiss
  • G3 (Bethesda).2019 12;9(12):3943-3952. g3.119.400413. doi: 10.1534/g3.119.400413.Epub 2019-12-03.

DMSOを介したいくつかの酵母プリオン変異体の治癒には、Hsp104の発現とタンパク質の可溶化が関与しており、いくつかのオートファジー関連遺伝子(atg)変異体では減少している

DMSO-mediated curing of several yeast prion variants involves Hsp104 expression and protein solubilization, and is decreased in several autophagy related gene (atg) mutants.
  • Jane E Dorweiler
  • Joanna O Obaoye
  • Mitch J Oddo
  • Francesca M Shilati
  • Grace M Scheidemantle
  • Thomas J Coleman
  • Jacob A Reilly
  • Gregory R Smith
  • Anita L Manogaran
  • PLoS ONE.2020;15(3):e0229796. PONE-D-19-23870. doi: 10.1371/journal.pone.0229796.Epub 2020-03-05.

ホモ接合性マッピングと全エクソームシークエンシングにより、サウジアラビアのある家族のコーエン症候群の正確な診断が可能となった

Homozygosity mapping and whole exome sequencing provide exact diagnosis of Cohen syndrome in a Saudi family.
  • Jamil A Hashmi
  • Fatima Fadhli
  • Ahmed Almatrafi
  • Sibtain Afzal
  • Khushnooda Ramzan
  • Holger Thiele
  • Peter Nürnberg
  • Sulman Basit
  • Brain Dev..2020 May;S0387-7604(20)30138-8. doi: 10.1016/j.braindev.2020.04.010.Epub 2020-05-10.

リンパ球-C-反応性タンパク質比率は、大腸がんの手術成績および腫瘍学的成績を予測する有望な新しいマーカーとして

Lymphocyte-C-reactive Protein Ratio as Promising New Marker for Predicting Surgical and Oncological Outcomes in Colorectal Cancer.
  • Yoshinaga Okugawa
  • Yuji Toiyama
  • Akira Yamamoto
  • Tsunehiko Shigemori
  • Shozo Ide
  • Takahito Kitajima
  • Hiroyuki Fujikawa
  • Hiromi Yasuda
  • Junichiro Hiro
  • Shigeyuki Yoshiyama
  • Takeshi Yokoe
  • Susumu Saigusa
  • Koji Tanaka
  • Yumiko Shirai
  • Minako Kobayashi
  • Masaki Ohi
  • Toshimitsu Araki
  • Donald C McMillan
  • Chikao Miki
  • Ajay Goel
  • Masato Kusunoki
  • Ann. Surg..2020 Aug;272(2):342-351. 00000658-202008000-00068. doi: 10.1097/SLA.0000000000003239.

心房細動のスクリーニングにおけるリズムモニタリング戦略の包括的評価。植え込み型ループレコーダーを用いて長期的にモニタリングされたリスクのある患者からの洞察

Comprehensive Evaluation of Rhythm Monitoring Strategies in Screening for Atrial Fibrillation: Insights From Patients at Risk Monitored Long Term With an Implantable Loop Recorder.
  • Søren Zöga Diederichsen
  • Ketil Jørgen Haugan
  • Christian Kronborg
  • Claus Graff
  • Søren Højberg
  • Lars Køber
  • Derk Krieger
  • Anders Gaarsdal Holst
  • Jonas Bille Nielsen
  • Axel Brandes
  • Jesper Hastrup Svendsen
  • Circulation.2020 May;141(19):1510-1522. doi: 10.1161/CIRCULATIONAHA.119.044407.Epub 2020-03-02.

COVID-19パンデミックとイブプロフェンまたはレニン-アンジオテンシン系遮断薬による治療：進行中の慢性治療の中断や変更は必要ない

COVID-19 pandemic and therapy with ibuprofen or renin-angiotensin system blockers: no need for interruptions or changes in ongoing chronic treatments.
  • Oliver Zolk
  • Susanne Hafner
  • Christoph Q Schmidt
  • Naunyn Schmiedebergs Arch. Pharmacol..2020 07;393(7):1131-1135. 10.1007/s00210-020-01890-6. doi: 10.1007/s00210-020-01890-6.Epub 2020-05-15.

COVID-19を有する入院中の高齢者における有罪率と死亡率。レトロスペクティブ観察研究

Frailty and Mortality in Hospitalized Older Adults With COVID-19: Retrospective Observational Study.
  • Robert De Smet
  • Bea Mellaerts
  • Hannelore Vandewinckele
  • Peter Lybeert
  • Eric Frans
  • Sara Ombelet
  • Wim Lemahieu
  • Rolf Symons
  • Erwin Ho
  • Johan Frans
  • Annick Smismans
  • Michaël R Laurent
  • J Am Med Dir Assoc.2020 Jul;21(7):928-932.e1. S1525-8610(20)30514-4. doi: 10.1016/j.jamda.2020.06.008.Epub 2020-06-09.

小豆のエチレン応答因子ファミリーのゲノムワイド解析と塩類アルカリストレス下でのVaERF3の機能決定

Genome-wide analysis of ethylene-response factor family in adzuki bean and functional determination of VaERF3 under saline-alkaline stress.
  • Wei-Yu Li
  • Cheng Wang
  • Heng-Hua Shi
  • Bo Wang
  • Jing-Xuan Wang
  • Yu-Shu Liu
  • Jing-Yu Ma
  • Sen-Ya Tian
  • Yao-Wen Zhang
  • Plant Physiol. Biochem..2020 Feb;147:215-222. S0981-9428(19)30535-2. doi: 10.1016/j.plaphy.2019.12.019.Epub 2019-12-17.

金ナノ粒子修飾スクリーン印刷電極を用いた分子インプリントポリマーをベースとした排水中のグリセロール定量用高感度・高選択性電気化学センサーの合成と特性評価

Synthesis and characterization of a highly sensitive and selective electrochemical sensor based on molecularly imprinted polymer with gold nanoparticles modified screen-printed electrode for glycerol determination in wastewater.
  • Soukaina Motia
  • Benachir Bouchikhi
  • Eduard Llobet
  • Nezha El Bari
  • Talanta.2020 Aug;216:120953. S0039-9140(20)30244-7. doi: 10.1016/j.talanta.2020.120953.Epub 2020-03-19.

高アンモニウム含有廃水処理のための単一反応器での部分硝化-アナモックスと短時間での硫黄自栄養脱窒の新規カップリングプロセス

A novel coupling process with partial nitritation-anammox and short-cut sulfur autotrophic denitrification in a single reactor for the treatment of high ammonium-containing wastewater.
  • Kuo Zhang
  • Tianli Kang
  • Sai Yao
  • Baorui Liang
  • Mingdong Chang
  • Youzhao Wang
  • Yongguang Ma
  • Liying Hao
  • Tong Zhu
  • Water Res..2020 Aug;180:115813. S0043-1354(20)30350-X. doi: 10.1016/j.watres.2020.115813.Epub 2020-04-27.

循環ミトコンドリアDNAとLPS結合タンパク質は、急性HIV感染では増加するが、細菌DNAは増加しない

Circulating mitochondrial DNA and LPS-binding protein but not bacterial DNA are increased in acute HIV infection.
  • Milena Nasi
  • Simone Pecorini
  • Sara De Biasi
  • Margherita Digaetano
  • Johanna Chester
  • Beatrice Aramini
  • Domenico Lo Tartaro
  • Marcello Pinti
  • Anna De Gaetano
  • Lara Gibellini
  • Anna Vittoria Mattioli
  • Cristina Mussini
  • Andrea Cossarizza
  • AIDS Res. Hum. Retroviruses.2020 Jul;doi: 10.1089/AID.2020.0098.Epub 2020-07-16.

エジプトでC型肝炎ウイルスに感染した患者から得られたヒトペギウイルス変異体の全ゲノム配列解析：症例報告

Whole-genome sequencing of human Pegivirus variant from an Egyptian patient co-infected with hepatitis C virus: a case report.
  • Hany K Soliman
  • Mohamed Abouelhoda
  • Mahmoud N El Rouby
  • Ola S Ahmed
  • G Esmat
  • Zeinab K Hassan
  • Mohammed M Hafez
  • Dina Ahmed Mehaney
  • Manojkumar Selvaraju
  • Rania Kamal Darwish
  • Yehia A Osman
  • Abdel-Rahman N Zekri
  • Virol. J..2019 11;16(1):132. 10.1186/s12985-019-1242-5. doi: 10.1186/s12985-019-1242-5.Epub 2019-11-11.

糖尿病ラット精巣に対するメラトニンの細胞レベル、ホルモンレベル、免疫組織化学的レベルでの保護作用

Protective action of melatonin on diabetic rat testis at cellular, hormonal and immunohistochemical levels.
  • Érique Ricardo Alves
  • Cintia Giselle Martins Ferreira
  • Maria Vanessa da Silva
  • Leucio Duarte Vieira Filho
  • Valdemiro Amaro da Silva Junior
  • Ismaela Maria Ferreira de Melo
  • Clovis José Cavalcanti Lapa Neto
  • Laís Caroline da Silva Santos
  • Álvaro Aguiar Coelho Teixeira
  • Valéria Wanderley Teixeira
  • Acta Histochem..2020 Jul;122(5):151559. S0065-1281(20)30058-1. doi: 10.1016/j.acthis.2020.151559.Epub 2020-05-26.

超音波頸動脈血流モニタリングにより評価した超カテーテル大動脈弁留置術中の高強度一過性信号。単一施設による前向き観察研究

High-intensity transient signals during transcatheter aortic valve implantation assessed by ultrasonic carotid artery blood-flow monitoring: A single center prospective observational study.
  • Shungo Aratake
  • Satoru Kayama
  • Yusuke Watanabe
  • Takahiro Honjo
  • Mae Harada
  • Taichi Onimaru
  • Shigehito Sawamura
  • J Cardiol.2020 Jul;S0914-5087(20)30212-4. doi: 10.1016/j.jjcc.2020.06.017.Epub 2020-07-13.

無血縁骨髄移植におけるHLA 1-3座ミスマッチと抗白血球グロブリン投与の影響

Influence of HLA 1-3-locus mismatch and antithymocyte globulin administration in unrelated bone marrow transplantation.
  • Koji Kawamura
  • Junya Kanda
  • Kazuteru Ohashi
  • Takahiro Fukuda
  • Koji Iwato
  • Tetsuya Eto
  • Shin-Ichiro Fujiwara
  • Takehiko Mori
  • Kentaro Fukushima
  • Yukiyasu Ozawa
  • Naoyuki Uchida
  • Takashi Ashida
  • Tatsuo Ichinohe
  • Yoshiko Atsuta
  • Yoshinobu Kanda
  • Ann. Hematol..2020 May;99(5):1099-1110. 10.1007/s00277-020-03995-7. doi: 10.1007/s00277-020-03995-7.Epub 2020-03-23.

IRSp53は、上皮性尿細管内腔での細胞膜の形状と偏光輸送を制御しています

IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules.
  • Sara Bisi
  • Stefano Marchesi
  • Abrar Rizvi
  • Davide Carra
  • Galina V Beznoussenko
  • Ines Ferrara
  • Gianluca Deflorian
  • Alexander Mironov
  • Giovanni Bertalot
  • Federica Pisati
  • Amanda Oldani
  • Angela Cattaneo
  • Ghazaleh Saberamoli
  • Salvatore Pece
  • Giuseppe Viale
  • Angela Bachi
  • Claudio Tripodo
  • Giorgio Scita
  • Andrea Disanza
  • Nat Commun.2020 Jul;11(1):3516. 10.1038/s41467-020-17091-x. doi: 10.1038/s41467-020-17091-x.Epub 2020-07-14.

新規なTRPM7/O-GlcNAc軸は、肺癌におけるc-Mycとcaveolin-1を安定化させることにより、腫瘍細胞の運動性と転移を媒介している

A novel TRPM7/O-GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma.
  • Sudjit Luanpitpong
  • Napachai Rodboon
  • Parinya Samart
  • Chanida Vinayanuwattikun
  • Siwaporn Klamkhlai
  • Pithi Chanvorachote
  • Yon Rojanasakul
  • Surapol Issaragrisil
  • Br. J. Cancer.2020 Jul;10.1038/s41416-020-0991-7. doi: 10.1038/s41416-020-0991-7.Epub 2020-07-20.

生殖期および閉経後のメキシコ女性における酸化ストレスのパラメータ

Parameters of Oxidative Stress in Reproductive and Postmenopausal Mexican Women.
  • Araceli Montoya-Estrada
  • Karla Guadalupe Velázquez-Yescas
  • Daniela Belen Veruete-Bedolla
  • José David Ruiz-Herrera
  • Alma Villarreal-Barranca
  • José Romo-Yañez
  • Guillermo Federico Ortiz-Luna
  • Arturo Arellano-Eguiluz
  • Mario Solis-Paredes
  • Arturo Flores-Pliego
  • Aurora Espejel-Nuñez
  • Guadalupe Estrada-Gutierrez
  • Enrique Reyes-Muñoz
  • Int J Environ Res Public Health.2020 02;17(5). E1492. doi: 10.3390/ijerph17051492.Epub 2020-02-26.

急性外傷性脳損傷におけるマスト細胞活性化、神経炎症、タイトジャンクション蛋白質の異常

Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury.
  • Duraisamy Kempuraj
  • Mohammad Ejaz Ahmed
  • Govindhasamy Pushpavathi Selvakumar
  • Ramasamy Thangavel
  • Sudhanshu P Raikwar
  • Smita A Zaheer
  • Shankar S Iyer
  • Casey Burton
  • Donald James
  • Asgar Zaheer
  • Mediators Inflamm..2020;2020:4243953. doi: 10.1155/2020/4243953.Epub 2020-06-24.

A Multiplexed HILIC-MS/HRMS Assay for Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials.有機カチオントランスポーター（OCT1）バイオマーカーとしてのイソブチリルカルニチン

A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker.
  • Lina Luo
  • Ragu Ramanathan
  • Lauren Horlbogen
  • Sumathy Mathialagan
  • Chester Costales
  • Manoli Vourvahis
  • Christopher L Holliman
  • A David Rodrigues
  • Anal. Chem..2020 Jul;doi: 10.1021/acs.analchem.0c01144.Epub 2020-07-02.

ラクトバチルス・プランタラムHEAL9の摂取は、急性ストレス時に可溶性フラクタルカインとCD163の炎症マーカーを減少させる。無作為化二重盲検プラセボ対照試験

Intake of Lactobacillus plantarum HEAL9 reduces the inflammatory markers soluble fractalkine and CD163 during acute stress: A randomized, double blind, placebo-controlled study.
  • Gunilla Önning
  • Magnus Hillman
  • Maria Hedin
  • Caroline Montelius
  • Joakim Eriksson
  • Siv Ahrné
  • Peter Jönsson
  • Physiol. Behav..2020 Jul;:113083. S0031-9384(20)30397-8. doi: 10.1016/j.physbeh.2020.113083.Epub 2020-07-17.

伸長因子-Ｔｕは、ｔＲＮＡ選択のプルーフリーディング段階において、リボソーム内のアミノアシル-ｔＲＮＡを繰り返し係合させることができる

Elongation factor-Tu can repetitively engage aminoacyl-tRNA within the ribosome during the proofreading stage of tRNA selection.
  • Justin C Morse
  • Dylan Girodat
  • Benjamin J Burnett
  • Mikael Holm
  • Roger B Altman
  • Karissa Y Sanbonmatsu
  • Hans-Joachim Wieden
  • Scott C Blanchard
  • Proc. Natl. Acad. Sci. U.S.A..2020 02;117(7):3610-3620. 1904469117. doi: 10.1073/pnas.1904469117.Epub 2020-02-05.

A Triad of Ketoacidosis, hypertriglyceridemia, and Acute Pancreatitis Associated With Sugar-Sweetened Soft Drinks Abuse in a Caucasian Patient With Uniagnosed Type 2 Diabetes Mellitus

A Triad of Ketoacidosis, Hypertriglyceridemia, and Acute Pancreatitis Associated With Sugar-Sweetened Soft Drinks Abuse in a Caucasian Patient With Undiagnosed Type 2 Diabetes Mellitus.
  • Alessandra Vitelli
  • Valentina Apuzzi
  • Francesco Calderaro
  • Olimpia Fattoruso
  • Vincenzo Bassi
  • Cureus.2020 May;12(5):e8299. doi: 10.7759/cureus.8299.Epub 2020-05-26.

バイオ炭とウレアーゼ・硝化抑制剤の複合施用は、水田におけるCH排出量削減に相乗効果を発揮する。3 年間の研究

Combined application of biochar with urease and nitrification inhibitors have synergistic effects on mitigating CH emissions in rice field: A three-year study.
  • Tiehu He
  • Junji Yuan
  • Jiafa Luo
  • Stuart Lindsey
  • Jian Xiang
  • Yongxin Lin
  • Deyan Liu
  • Zengming Chen
  • Weixin Ding
  • Sci. Total Environ..2020 Jul;743:140500. S0048-9697(20)34022-5. doi: 10.1016/j.scitotenv.2020.140500.Epub 2020-07-03.

南アフリカ、ムプマランガ州の急性発熱患者における細菌性人獣共通感染症の危険因子

Risk factors for bacterial zoonotic pathogens in acutely febrile patients in Mpumalanga Province, South Africa.
  • Amanda M Berrian
  • Beatriz Martínez-López
  • Vanessa Quan
  • Patricia A Conrad
  • Jacques van Rooyen
  • Gregory J G Simpson
  • John Frean
  • Jacqueline Weyer
  • Jennifer Rossouw
  • Darryn Knobel
  • Lucille Blumberg
  • Zoonoses Public Health.2019 08;66(5):458-469. doi: 10.1111/zph.12577.Epub 2019-03-11.

TP53突然変異のランドスケープを計算科学的に解析すると、頭頸部扁平上皮癌における予後の鍵となるシグネチャーと明確な経路が明らかになる

Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer.
  • Vito Carlo Alberto Caponio
  • Giuseppe Troiano
  • Iolanda Adipietro
  • Khrystyna Zhurakivska
  • Claudia Arena
  • Domenica Mangieri
  • Marco Mascitti
  • Nicola Cirillo
  • Lorenzo Lo Muzio
  • Br. J. Cancer.2020 Jul;10.1038/s41416-020-0984-6. doi: 10.1038/s41416-020-0984-6.Epub 2020-07-20.

樹脂抽出物の抗炎症性組成物は、ラットのモノヨードアセテート誘発性変形性関節炎における疼痛を緩和し、軟骨を保護する

An Anti-Inflammatory Composition of Resin Extracts Alleviates Pain and Protects Cartilage in Monoiodoacetate-Induced Osteoarthritis in Rats.
  • Venkata Krishnaraju Alluri
  • Sreenath Kundimi
  • Krishanu Sengupta
  • Trimurtulu Golakoti
  • Eswar Kumar Kilari
  • Evid Based Complement Alternat Med.2020;2020:7381625. doi: 10.1155/2020/7381625.Epub 2020-05-21.

経皮的冠動脈インターベンション成功後の急性心筋梗塞患者および糖尿病予備軍患者における、耐久性のあるポリマーと生分解性ポリマーをベースとした新世代の薬剤溶出ステントの比較

Comparison of Durable-Polymer- and Biodegradable-Polymer-Based Newer-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes After Successful Percutaneous Coronary Intervention.
  • Yong Hoon Kim
  • Ae-Young Her
  • Myung Ho Jeong
  • Byeong-Keuk Kim
  • Sung-Jin Hong
  • Seunghwan Kim
  • Chul-Min Ahn
  • Jung-Sun Kim
  • Young-Guk Ko
  • Donghoon Choi
  • Myeong-Ki Hong
  • Yangsoo Jang
  • Int Heart J.2020 Jul;doi: 10.1536/ihj.19-654.Epub 2020-07-18.

ラット後根神経節ニューロンにおけるKv7.2のRNA干渉を介したサイレンシングは、選択的チャネルオープナーの抗侵害受容作用を消失させることがわかった

RNA interference-mediated silencing of Kv7.2 in rat dorsal root ganglion neurons abolishes the anti-nociceptive effect of a selective channel opener.
  • Markus Valdor
  • Anke Wagner
  • Heike Fischer
  • Viola Röhrs
  • Wolfgang Schröder
  • Gregor Bahrenberg
  • André Welbers
  • Henry Fechner
  • Jens Kurreck
  • Thomas M Tzschentke
  • Thomas Christoph
  • J Pharmacol Toxicol Methods.2020 May - Jun;103:106693. S1056-8719(20)30022-8. doi: 10.1016/j.vascn.2020.106693.Epub 2020-04-08.