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日本語AIでPubMedを検索

歯科医師情報サイトTOP / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
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2020年07月 みんなが読んでいる論文

イソベンゾナフラノンとオイゲノールとインダン-1,3-ジオンのトリアゾリック誘導体を足場とした新規な西ナイルウイルスプロテアーゼ阻害剤の発見

Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds.
  • André S de Oliveira
  • Poliana A R Gazolla
  • Ana Flávia C da S Oliveira
  • Wagner L Pereira
  • Lívia C de S Viol
  • Angélica F da S Maia
  • Edjon G Santos
  • Ítalo E P da Silva
  • Tiago A de Oliveira Mendes
  • Adalberto M da Silva
  • Roberto S Dias
  • Cynthia C da Silva
  • Marcelo D Polêto
  • Róbson R Teixeira
  • Sergio O de Paula
  • PLoS ONE.2019;14(9):e0223017. PONE-D-19-08554. doi: 10.1371/journal.pone.0223017.Epub 2019-09-26.

コントラスト増強磁気共鳴イメージングにより、アストロサイト・アクアポリン-4水チャネルが糖質流入と間質性溶質輸送に果たす役割の証拠が得られた

Contrast-enhanced magnetic resonance imaging evidence for the role of astrocytic aquaporin-4 water channels in glymphatic influx and interstitial solute transport.
  • Kazuki Takano
  • Masayuki Yamada
  • Magn Reson Imaging.2020 May;71:11-16. S0730-725X(19)30694-0. doi: 10.1016/j.mri.2020.05.001.Epub 2020-05-20.

猛禽類における汚染物質モニタリングのための概略的なサンプリングプロトコル

A schematic sampling protocol for contaminant monitoring in raptors.
  • Silvia Espín
  • Jovan Andevski
  • Guy Duke
  • Igor Eulaers
  • Pilar Gómez-Ramírez
  • Gunnar Thor Hallgrimsson
  • Björn Helander
  • Dorte Herzke
  • Veerle L B Jaspers
  • Oliver Krone
  • Rui Lourenço
  • Pedro María-Mojica
  • Emma Martínez-López
  • Rafael Mateo
  • Paola Movalli
  • Pablo Sánchez-Virosta
  • Richard F Shore
  • Christian Sonne
  • Nico W van den Brink
  • Bert van Hattum
  • Al Vrezec
  • Chris Wernham
  • Antonio J García-Fernández
  • Ambio.2020 May;10.1007/s13280-020-01341-9. doi: 10.1007/s13280-020-01341-9.Epub 2020-05-12.

オートファジー阻害は、トランスフォーミング成長因子β（TGF-β）によって誘導されるG1停止に腎尿細管上皮細胞を感作する

Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-β).
  • Chen Yang
  • Hong-Luan Wu
  • Zhi-Hang Li
  • Xiao-Cui Chen
  • Hong-Yong Su
  • Xiao-Yan Guo
  • Ning An
  • Kai-Peng Jing
  • Qing-Jun Pan
  • Hua-Feng Liu
  • Med. Sci. Monit..2020 Jun;26:e922673. 922673. doi: 10.12659/MSM.922673.Epub 2020-06-07.

相分離（OOPS）を用いたRNA結合型プロテオームとタンパク質結合型トランスクリプトームの効率的な回収

Efficient recovery of the RNA-bound proteome and protein-bound transcriptome using phase separation (OOPS).
  • Eneko Villanueva
  • Tom Smith
  • Rayner M L Queiroz
  • Mie Monti
  • Mariavittoria Pizzinga
  • Mohamed Elzek
  • Veronica Dezi
  • Robert F Harvey
  • Manasa Ramakrishna
  • Anne E Willis
  • Kathryn S Lilley
  • Nat Protoc.2020 Jul;10.1038/s41596-020-0344-2. doi: 10.1038/s41596-020-0344-2.Epub 2020-07-10.

トリプルネガティブ乳がん細胞における抗増殖遺伝子B細胞転座遺伝子2によるTwist1発現のトランスレーショナルダウンレギュレーション

Translational downregulation of Twist1 expression by antiproliferative gene, B-cell translocation gene 2, in the triple negative breast cancer cells.
  • Preethi Devanand
  • Santhoshkumar Sundaramoorthy
  • Min Sook Ryu
  • Aravinth Kumar Jayabalan
  • Takbum Ohn
  • In Kyoung Lim
  • Cell Death Dis.2019 05;10(6):410. 10.1038/s41419-019-1640-z. doi: 10.1038/s41419-019-1640-z.Epub 2019-05-28.

減衰全反射-フーリエ変換赤外分光法とケモメトリクスによるヘロイン、メタンフェタミン、ケタミンおよびそれらの添加物の分類

Classification of heroin, methamphetamine, ketamine and their additives by attenuated total reflection-Fourier transform infrared spectroscopy and chemometrics.
  • Xinlong He
  • Jifen Wang
  • Xinwei You
  • Fan Niu
  • Linyuan Fan
  • Yufan Lv
  • Spectrochim Acta A Mol Biomol Spectrosc.2020 Jul;241:118665. S1386-1425(20)30644-2. doi: 10.1016/j.saa.2020.118665.Epub 2020-07-11.

強力な抗ライシュマニア活性を有する8-ヒドロキシナフチリジンの同定と最適化。初期SARと活性の評価

Identification and optimisation of a series of 8-hydroxy naphthyridines with potent antileishmanial activity: Initial SAR and assessment of activity.
  • Michael Thomas
  • Manu De Rycker
  • Richard J Wall
  • Daniel Spinks
  • Ola Epemolu
  • Sujatha Manthri
  • Suzanne Norval
  • Maria Osuna-Cabello
  • Stephen Patterson
  • Jennifer Riley
  • Frederick R C Simeons
  • Laste Stojanovski
  • John Thomas
  • Stephen Thompson
  • Claire Naylor
  • Jose M Fiandor
  • Paul G Wyatt
  • Maria Marco
  • Susan Wyllie
  • Kevin D Read
  • Timothy J Miles
  • Ian H Gilbert
  • J. Med. Chem..2020 Jul;doi: 10.1021/acs.jmedchem.0c00705.Epub 2020-07-14.

S100A9は、TLR4/TNF経路を介して帯状疱疹神経痛のマウスモデルにおいて重要な役割を果たしています

S100A9 plays a pivotal role in a mouse model of herpetic neuralgia via TLR4/TNF pathway.
  • Cássia R Silva
  • Bruno M S Melo
  • Jaqueline R Silva
  • Alexandre H Lopes
  • Janaina A Pereira
  • Nerry T Cecilio
  • Jonilson Berlink
  • Giovani G Souza
  • Guilherme Lucas
  • Thomas Vogl
  • Fernando Q Cunha
  • José C Alves-Filho
  • Thiago M Cunha
  • Brain Behav. Immun..2020 Mar;S0889-1591(19)31492-8. doi: 10.1016/j.bbi.2020.03.033.Epub 2020-03-31.

副甲状腺ホルモン、1.25(OH)D、および線維芽細胞増殖因子 23 が産卵鶏のさまざまな組織におけるカルシウム代謝を制御する遺伝子に及ぼす可能性のある役割

Possible roles of parathyroid hormone, 1.25(OH)D, and fibroblast growth factor 23 on genes controlling calcium metabolism across different tissues of the laying hen.
  • A Gloux
  • N Le Roy
  • J Ezagal
  • N Même
  • C Hennequet-Antier
  • M L Piketty
  • D Prié
  • G Benzoni
  • J Gautron
  • Y Nys
  • A Narcy
  • M J Duclos
  • Domest. Anim. Endocrinol..2020 Jul;72:106407. S0739-7240(19)30086-4. doi: 10.1016/j.domaniend.2019.106407.Epub 2019-10-23.

パラス女性における骨盤底筋と尿失禁の治療に対する高強度集束電磁技術と電気刺激の効果に関する比較研究。治療後のデータの分析

A Comparative Study on the Effects of High-Intensity Focused Electromagnetic Technology and Electrostimulation for the Treatment of Pelvic Floor Muscles and Urinary Incontinence in Parous Women: Analysis of Posttreatment Data.
  • Elena Silantyeva
  • Dragana Zarkovic
  • Evgeniia Astafeva
  • Ramina Soldatskaia
  • Mekan Orazov
  • Marina Belkovskaya
  • Mark Kurtser
  • Female Pelvic Med Reconstr Surg.2020 Jan;doi: 10.1097/SPV.0000000000000807.Epub 2020-01-25.

血小板が豊富な血漿（PRP）は、血管新生とコラーゲン合成を促進することで、マウスの膝蓋腱の治癒を促進します

Platelet-rich plasma (PRP) accelerates murine patellar tendon healing through enhancement of angiogenesis and collagen synthesis.
  • Yohei Kobayashi
  • Yoshitomo Saita
  • Tomoiku Takaku
  • Tomomasa Yokomizo
  • Hirofumi Nishio
  • Hiroshi Ikeda
  • Yuji Takazawa
  • Masashi Nagao
  • Kazuo Kaneko
  • Norio Komatsu
  • J Exp Orthop.2020 Jul;7(1):49. 10.1186/s40634-020-00267-1. doi: 10.1186/s40634-020-00267-1.Epub 2020-07-08.

ドイツ領北海（北海）の一般的な洋上風力発電所の基礎に生息する移動性海底メガファウナ - 展開から2年後、Cancer pagurusの生産量が増加している

Mobile demersal megafauna at common offshore wind turbine foundations in the German Bight (North Sea) two years after deployment - increased production rate of Cancer pagurus.
  • R Krone
  • G Dederer
  • P Kanstinger
  • P Krämer
  • C Schneider
  • I Schmalenbach
  • Mar. Environ. Res..2017 Feb;123:53-61. S0141-1136(16)30301-4. doi: 10.1016/j.marenvres.2016.11.011.Epub 2016-11-29.

p21 の過剰発現は、細胞周期制御を介して CD43＋細胞の生成を阻害することで、ヒト造血に抑制効果がある

Overexpression of p21 Has Inhibitory Effect on Human Hematopoiesis by Blocking Generation of CD43＋ Cells via Cell-Cycle Regulation.
  • Jiahui Zeng
  • Huifang Zhang
  • Yuanling Liu
  • Wencui Sun
  • Danying Yi
  • Lijiao Zhu
  • Yonggang Zhang
  • Xu Pan
  • Yijing Chen
  • Ya Zhou
  • Guohui Bian
  • Mowen Lai
  • Qiongxiu Zhou
  • Jiaxin Liu
  • Bo Chen
  • Feng Ma
  • Int J Stem Cells.2020 Jul;13(2):202-211. ijsc20033. doi: 10.15283/ijsc20033.

バキュロウイルス蛋白質発現系を用いた生きた昆虫細胞の蛋白質の高分解能異核多次元NMR

High-resolution heteronuclear multidimensional NMR of proteins in living insect cells using a baculovirus protein expression system.
  • Jumpei Hamatsu
  • Daniel O'Donovan
  • Takashi Tanaka
  • Takahiro Shirai
  • Yuichiro Hourai
  • Tsutomu Mikawa
  • Teppei Ikeya
  • Masaki Mishima
  • Wayne Boucher
  • Brian O Smith
  • Ernest D Laue
  • Masahiro Shirakawa
  • Yutaka Ito
  • J. Am. Chem. Soc..2013 Feb;135(5):1688-91. doi: 10.1021/ja310928u.Epub 2013-01-27.

DNA複製タンパク質Cdc45は、Leishmania donovaniのPIPボックスを介してPCNAと直接相互作用し、Cdc45のPIPボックスは細胞の生存に不可欠である

DNA replication protein Cdc45 directly interacts with PCNA via its PIP box in Leishmania donovani and the Cdc45 PIP box is essential for cell survival.
  • Aarti Yadav
  • Varshni Sharma
  • Jyoti Pal
  • Pallavi Gulati
  • Manisha Goel
  • Udita Chandra
  • Neha Bansal
  • Swati Saha
  • PLoS Pathog..2020 05;16(5):e1008190. PPATHOGENS-D-19-02030. doi: 10.1371/journal.ppat.1008190.Epub 2020-05-15.

良性家族性乳児性痙攣：2q24番染色体上の新規遺伝子座のマッピングと遺伝的異質性の証拠

Benign familial infantile convulsions: mapping of a novel locus on chromosome 2q24 and evidence for genetic heterogeneity.
  • M Malacarne
  • E Gennaro
  • F Madia
  • S Pozzi
  • D Vacca
  • B Barone
  • B dalla Bernardina
  • A Bianchi
  • P Bonanni
  • P De Marco
  • A Gambardella
  • L Giordano
  • M L Lispi
  • A Romeo
  • E Santorum
  • F Vanadia
  • M Vecchi
  • P Veggiotti
  • F Vigevano
  • F Viri
  • F D Bricarelli
  • F Zara
  • Am. J. Hum. Genet..2001 Jun;68(6):1521-6. S0002-9297(07)61064-7. doi: 10.1086/320596.Epub 2001-04-20.

開口緑内障および眼圧亢進症に対するビマトプロストインプラントの第3相無作為化20ヵ月間試験（ARTEMIS 1）

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).
  • Felipe A Medeiros
  • Thomas R Walters
  • Miriam Kolko
  • Michael Coote
  • Marina Bejanian
  • Margot L Goodkin
  • Qiang Guo
  • Jane Zhang
  • Michael R Robinson
  • Robert N Weinreb
  • Ophthalmology.2020 Jun;S0161-6420(20)30555-8. doi: 10.1016/j.ophtha.2020.06.018.Epub 2020-06-13.

数学的に導かれたアプローチを用いて、マウスモデルにおけるキメラ抗原受容体T細胞の投与数を減少させる

Less is more: reducing the number of administered chimeric antigen receptor T cells in a mouse model using a mathematically guided approach.
  • Anat Globerson Levin
  • Natalie Kronik
  • Tamar Shiloach
  • Tova Waks
  • Zelig Eshhar
  • Vladimir Vainstein
  • Cancer Immunol. Immunother..2020 Jul;69(7):1165-1175. 10.1007/s00262-020-02516-9. doi: 10.1007/s00262-020-02516-9.Epub 2020-03-04.

LQFM126プロトタイプのB16F10メラノーマ細胞に対する抗血管新生・抗腫瘍活性

Antiangiogenic and antitumoral activity of LQFM126 prototype against B16F10 melanoma cells.
  • Artur Christian Garcia da Silva
  • Bruna Dos Santos Rodrigues
  • Wanessa Machado Andrade
  • Thaís Rosa Marques Dos Santos
  • Flávio Silva de Carvalho
  • Germán Sanz
  • Boniek G Vaz
  • Luciano M Lião
  • Ricardo Menegatti
  • Marize Campos Valadares
  • Chem. Biol. Interact..2020 Jul;325:109127. S0009-2797(20)30404-X. doi: 10.1016/j.cbi.2020.109127.Epub 2020-05-11.

穴が多ければコントラストが上がる？心臓CTにおける18ゲージの非開孔カテーテルと22ゲージの開孔カテーテルの比較

More holes, more contrast? Comparing an 18-gauge non-fenestrated catheter with a 22-gauge fenestrated catheter for cardiac CT.
  • Andreas Marco Fischer
  • Philipp Riffel
  • Thomas Henzler
  • U Joseph Schoepf
  • Andres F Abadia
  • Richard Robert Bayer
  • Holger Haubenreisser
  • Dante Giovagnoli
  • Alexander Kremer
  • Stefan O Schoenberg
  • Joshua Gawlitza
  • PLoS ONE.2020;15(6):e0234311. PONE-D-19-24782. doi: 10.1371/journal.pone.0234311.Epub 2020-06-08.

雄性ラットにおける片側慢性拘縮損傷による能動相随意輪走の抑制。TLR4またはP2X7アンタゴニストにモルヒネを短時間投与した場合の持続的な治療効果

Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists.
  • Suzanne M Green-Fulgham
  • Jayson B Ball
  • Steven F Maier
  • Kenner C Rice
  • Linda R Watkins
  • Peter M Grace
  • J. Neurosci. Res..2020 Jun;doi: 10.1002/jnr.24645.Epub 2020-06-13.

バングラデシュ農村部の幼い子供たちの呼吸器疾患に対する水質、衛生、衛生、栄養改善の効果。多施設クラスター無作為化対照試験

Effect of Improved Water Quality, Sanitation, Hygiene and Nutrition Interventions on Respiratory Illness in Young Children in Rural Bangladesh: A Multi-Arm Cluster-Randomized Controlled Trial.
  • Sania Ashraf
  • Mahfuza Islam
  • Leanne Unicomb
  • Mahbubur Rahman
  • Peter J Winch
  • Benjamin F Arnold
  • Jade Benjamin-Chung
  • Pavani K Ram
  • John M Colford
  • Stephen P Luby
  • Am. J. Trop. Med. Hyg..2020 05;102(5):1124-1130. doi: 10.4269/ajtmh.19-0769.

MicroRNA-10aは概日時計遺伝子の発現低下を介してC型肝炎ウイルス関連肝硬変の肝代謝を損なう 脳と筋肉のアリール炭化水素受容体核トランスロケーター-Like 1

MicroRNA-10a Impairs Liver Metabolism in Hepatitis C Virus-Related Cirrhosis Through Deregulation of the Circadian Clock Gene Brain and Muscle Aryl Hydrocarbon Receptor Nuclear Translocator-Like 1.
  • Rika Horii
  • Masao Honda
  • Takayoshi Shirasaki
  • Tetsuro Shimakami
  • Ryogo Shimizu
  • Souma Yamanaka
  • Kazuhisa Murai
  • Kazunori Kawaguchi
  • Kuniaki Arai
  • Tatsuya Yamashita
  • Yoshio Sakai
  • Taro Yamashita
  • Hikari Okada
  • Mikiko Nakamura
  • Eishiro Mizukoshi
  • Shuichi Kaneko
  • Hepatol Commun.2019 Dec;3(12):1687-1703. HEP41431. doi: 10.1002/hep4.1431.Epub 2019-09-26.

強く閉じ込められたペロブスカイト量子ドットをベースとした青色LED用バイポーラ・シェル・リサーフェシング

Bipolar-shell resurfacing for blue LEDs based on strongly confined perovskite quantum dots.
  • Yitong Dong
  • Ya-Kun Wang
  • Fanglong Yuan
  • Andrew Johnston
  • Yuan Liu
  • Dongxin Ma
  • Min-Jae Choi
  • Bin Chen
  • Mahshid Chekini
  • Se-Woong Baek
  • Laxmi Kishore Sagar
  • James Fan
  • Yi Hou
  • Mingjian Wu
  • Seungjin Lee
  • Bin Sun
  • Sjoerd Hoogland
  • Rafael Quintero-Bermudez
  • Hinako Ebe
  • Petar Todorovic
  • Filip Dinic
  • Peicheng Li
  • Hao Ting Kung
  • Makhsud I Saidaminov
  • Eugenia Kumacheva
  • Erdmann Spiecker
  • Liang-Sheng Liao
  • Oleksandr Voznyy
  • Zheng-Hong Lu
  • Edward H Sargent
  • Nat Nanotechnol.2020 Jul;10.1038/s41565-020-0714-5. doi: 10.1038/s41565-020-0714-5.Epub 2020-07-06.

Hunigの塩基は、強力な抗酸化剤および2HCK酵素増殖阻害剤としての新規な1-(2,3-ジヒドロ-1H-インデン-1-イル)-3-アリール尿素/チオ尿素誘導体の合成を触媒した

Hunig's base catalyzed synthesis of new 1-(2,3-dihydro-1H-inden-1-yl)-3-aryl urea/thiourea derivatives as potent antioxidants and 2HCK enzyme growth inhibitors.
  • Venkataramana Lachhi Reddy
  • Vijay Kumar Reddy Avula
  • Grigoriy V Zyryanov
  • Swetha Vallela
  • Jaya Shree Anireddy
  • Visweswara Rao Pasupuleti
  • Naga Raju Chamarthi
  • Bioorg. Chem..2020 Jan;95:103558. S0045-2068(19)31680-3. doi: 10.1016/j.bioorg.2019.103558.Epub 2019-12-29.

ZnO/PEG-Co(II)-PbOナノコンポジット電極の作製と特性評価、フェノールの電極触媒分解の検討

Preparation and characterization of ZnO/PEG-Co(II)-PbO nanocomposite electrode and an investigation of the electrocatalytic degradation of phenol.
  • Lai Gui
  • Zhen Chen
  • Bangyao Chen
  • Yuzhu Song
  • Qiang Yu
  • Wei Zhu
  • Qi Hu
  • Yuanyuan Liu
  • Zhaoyi Zheng
  • Lv Ze
  • Hongjun You
  • Farhana Yeasmin
  • J. Hazard. Mater..2020 May;399:123018. S0304-3894(20)31007-4. doi: 10.1016/j.jhazmat.2020.123018.Epub 2020-05-30.

ガルシノイン酸は、マウスの脳におけるβアミロイド（Aβ）の沈着を防ぎます

Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain.
  • Rita Marinelli
  • Pierangelo Torquato
  • Desirée Bartolini
  • Cristina Mas-Bargues
  • Guido Bellezza
  • Antimo Gioiello
  • Consuelo Borras
  • Antonella De Luca
  • Francesca Fallarino
  • Bartolomeo Sebastiani
  • Sridhar Mani
  • Angelo Sidoni
  • Jose Vina
  • Manuela Leri
  • Monica Bucciantini
  • Pamela Nardiello
  • Fiorella Casamenti
  • Francesco Galli
  • J. Biol. Chem..2020 Jul;jbc.RA120.013303. doi: 10.1074/jbc.RA120.013303.Epub 2020-07-02.

眼周囲低酸素は、一般化した強直間代発作に伴う局所脳容積減少の程度と関連している

Peri-ictal hypoxia is related to extent of regional brain volume loss accompanying generalized tonic-clonic seizures.
  • Luke A Allen
  • Ronald M Harper
  • Sjoerd B Vos
  • Catherine A Scott
  • Nuria Lacuey
  • Laura Vilella
  • Joel S Winston
  • Benjamin P Whatley
  • Rajesh Kumar
  • Jennifer Ogren
  • Jaison S Hampson
  • Sandhya Rani
  • Gavin P Winston
  • Louis Lemieux
  • Samden D Lhatoo
  • Beate Diehl
  • Epilepsia.2020 Jul;doi: 10.1111/epi.16615.Epub 2020-07-19.

潰瘍性大腸炎患者のQOL、エンパワーメント、意思決定、疾患コントロールを向上させるウェブベースの意思決定支援（myAID）。クラスター無作為化対照試験のプロトコール

A Web-Based Decision Aid (myAID) to Enhance Quality of Life, Empowerment, Decision Making, and Disease Control for Patients With Ulcerative Colitis: Protocol for a Cluster Randomized Controlled Trial.
  • Andrew H Kim
  • Afaf Girgis
  • Neda Karimi
  • Alexandra J Sechi
  • Joseph Descallar
  • Jane M Andrews
  • Corey A Siegel
  • Susan J Connor
  • JMIR Res Protoc.2020 Jul;9(7):e15994. v9i7e15994. doi: 10.2196/15994.Epub 2020-07-10.

1990年から2015年までのイランの国・州レベルでの転倒関連死亡率の推移

The trend of fall-related mortality at national and provincial levels in Iran from 1990 to 2015.
  • Zahra Ghodsi
  • Man Amanat
  • Sahar Saeedi Moghaddam
  • Payam Vezvaei
  • Kimiya Gohari
  • Rosa Haghshenas
  • Mohammad Hosein Amirzade-Iranaq
  • Nazila Rezaei
  • Soheil Saadat
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DDI2は転写因子NRF1の切断に関与するユビキチン指向型エンドプロテアーゼである

DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1.
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IgM型多発性骨髄腫に起因する早期発症型過蓋胞性症候群の鑑別が困難な症例の診断：1 症例報告

Diagnosis of a difficult to differentiate case of early-onset hyperviscosity syndrome caused by IgM type multiple myeloma: a case report.
  • Takuro Yoshimura
  • Yoshiki Hayashi
  • Katsujun Shimizu
  • Naoko Yagi
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  • Mirei Horiuchi
  • Masahiro Yoshida
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Crotonaldehyde-induced vascular relaxation and toxicity.Role of endothelium and Transient receptor potential ankyrin-1 (TRPA1)」Toxicol Appl Pharmacol.398 (2020) 115012

Corrigendum to "Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and Transient receptor potential ankyrin-1 (TRPA1)" [Toxicol Appl Pharmacol. 398 (2020) 115012].
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  • Toxicol. Appl. Pharmacol..2020 Aug;401:115114. S0041-008X(20)30240-4. doi: 10.1016/j.taap.2020.115114.Epub 2020-06-26.

原発性非尿道性腸型腺癌、尿路腺癌、粘膜腺癌、および腸管メタプラシア/腺腫の分子遺伝学的特徴。文献レビューと次世代シークエンシング研究

Molecular Genetic Features of Primary Nonurachal Enteric-type Adenocarcinoma, Urachal Adenocarcinoma, Mucinous Adenocarcinoma, and Intestinal Metaplasia/Adenoma: Review of the Literature and Next-generation Sequencing Study.
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  • Delia M Perez Montiel
  • Stela Bulimbasic
  • João Lobo
  • Rui Henrique
  • Tomas Vanecek
  • Kristyna Pivovarcikova
  • Kvetoslava Michalova
  • Tomas Pitra
  • Milan Hora
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  • Jose M Lopes
  • Joanna Rogala
  • Jana Mareckova
  • Michal Michal
  • Ondrej Hes
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ウィスコット・アルドリッチ症候群のタンパク質は、ヒトの T および B リンパ球における細胞保護ゴルジ分散反応を調整するために、照射誘発 DNA ダメージを感知します

Wiskott-Aldrich syndrome protein senses irradiation-induced DNA damage to coordinate the cell-protective Golgi dispersal response in human T and B lymphocytes.
  • Kuo-Kuang Wen
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  • Yatin M Vyas
  • J. Allergy Clin. Immunol..2020 Jan;145(1):324-334. S0091-6749(19)31263-1. doi: 10.1016/j.jaci.2019.09.026.Epub 2019-10-09.

第2世代と第3世代の薬剤溶出ステント留置術におけるステント後の不整脈突出とその後の新内膜特性の比較

Comparison of post-stent irregular protrusion and subsequent neointimal characteristics between second- and third-generation drug-eluting stent implantation.
  • Toshiya Miura
  • Shinjo Sonoda
  • Yoshinori Sanuki
  • Yutaro Naka
  • Hiroki Okabe
  • Koshi Setoyama
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  • Akiyoshi Shimizu
  • Reo Anai
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  • Yutaka Otsuji
  • J Cardiol.2020 Jul;S0914-5087(20)30175-1. doi: 10.1016/j.jjcc.2020.05.013.Epub 2020-07-04.

Micro QuEChERSをベースにした、野生動物の毒性に関連する360種類の汚染物質を全血中で同時にバイオモニタリングするためのメソッド

Micro QuEChERS-based method for the simultaneous biomonitoring in whole blood of 360 toxicologically relevant pollutants for wildlife.
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  • Sci. Total Environ..2020 Sep;736:139444. S0048-9697(20)32961-2. doi: 10.1016/j.scitotenv.2020.139444.Epub 2020-05-15.

肉腫患者の代替スプライシングの系統的プロファイリングから、腫瘍の微小環境と免疫細胞に関連した新しい予後バイオマーカーが明らかになった

Systematic Profiling of Alternative Splicing for Sarcoma Patients Reveals Novel Prognostic Biomarkers Associated with Tumor Microenvironment and Immune Cells.
  • Chuan Hu
  • Yuanhe Wang
  • Chuan Liu
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  • Kang Sun
  • Huili Rao
  • Lin Ye
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  • Med. Sci. Monit..2020 Jul;26:e924126. 924126. doi: 10.12659/MSM.924126.Epub 2020-07-19.

切除不能な食道癌に対するステント留置と追加の腫瘍学的治療の有効性と安全性、ステント留置単独と比較した場合の有効性と安全性。メタアナリシスとシステマティックレビュー

Efficacy and safety of stenting and additional oncological treatment versus stenting alone in unresectable esophageal cancer: A meta-analysis and systematic review.
  • Benedek Tinusz
  • Alexandra Soós
  • Péter Hegyi
  • Patrícia Sarlós
  • László Szapáry
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  • Donáta Feczák
  • Zsolt Szakács
  • Katalin Márta
  • Viktória Venglovecz
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  • Radiother Oncol.2020 Jun;147:169-177. S0167-8140(20)30268-1. doi: 10.1016/j.radonc.2020.05.015.Epub 2020-05-15.

デキストラン硫酸ナトリウム誘発性大腸炎モデルにおけるネオアガロテトラオースのプレバイオティクス作用を予測する分子および微生物シグネチャー

Molecular and Microbial Signatures Predictive of Prebiotic Action of Neoagarotetraose in a Dextran Sulfate Sodium-Induced Murine Colitis Model.
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  • Microorganisms.2020 Jul;8(7). E995. doi: 10.3390/microorganisms8070995.Epub 2020-07-03.

鳥類の頂点捕食者を用いた化学物質モニタリングの調和に向けて。全欧的なバイオモニタリングのための主要な種の同定

Towards harmonisation of chemical monitoring using avian apex predators: Identification of key species for pan-European biomonitoring.
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  • Madis Leivits
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細菌ナノセルロース小径血管移植片のインビトロでの吸血および細胞適合性。作製と表面特性の影響

In vitro hemo- and cytocompatibility of bacterial nanocelluose small diameter vascular grafts: Impact of fabrication and surface characteristics.
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  • Ingo Slottosch
  • George Awad
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  • Sam Varghese
  • Maurice Klopfleisch
  • Dennis Kupitz
  • Dieter Klemm
  • Sandor Nietzsche
  • Katrin Petzold-Welcke
  • Friederike Kramer
  • Jens Wippermann
  • Priya Veluswamy
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  • PLoS ONE.2020;15(6):e0235168. PONE-D-19-28143. doi: 10.1371/journal.pone.0235168.Epub 2020-06-24.

肺移植患者における定量的多容量陽子磁気共鳴イメージング。コンピュータ断層撮影およびスピロメトリーとの比較

Quantitative Multivolume Proton-Magnetic Resonance Imaging in Lung Transplant Recipients: Comparison With Computed Tomography and Spirometry.
  • Francesca Pennati
  • Caterina Salito
  • Irene Borzani
  • Gianpaolo Carrafiello
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  • Valentina Vaira
  • Mario Nosotti
  • Alessandro Palleschi
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  • Acad Radiol.2020 Jul;S1076-6332(20)30331-7. doi: 10.1016/j.acra.2020.05.026.Epub 2020-07-08.

真核生物の開始因子（eIF）3は、大麦黄色矮性ウイルスmRNAの3'-5'UTR相互作用と40Sリボソームサブユニット結合を仲介し、キャップに依存しない翻訳を促進する

Eukaryotic initiation factor (eIF) 3 mediates Barley Yellow Dwarf Viral mRNA 3'-5' UTR interactions and 40S ribosomal subunit binding to facilitate cap-independent translation.
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  • Paul Powell
  • Dixie J Goss
  • Nucleic Acids Res..2019 07;47(12):6225-6235. 5494776. doi: 10.1093/nar/gkz448.

鳥類および哺乳類に対する現行の農薬リスク評価によるコウモリの対象範囲に関する科学的声明

Scientific statement on the coverage of bats by the current pesticide risk assessment for birds and mammals.
  • Antonio Hernández-Jerez
  • Paulien Adriaanse
  • Annette Aldrich
  • Philippe Berny
  • Tamara Coja
  • Sabine Duquesne
  • Anne Louise Gimsing
  • Marinovich Marina
  • Maurice Millet
  • Olavi Pelkonen
  • Silvia Pieper
  • Aaldrik Tiktak
  • Ioanna Tzoulaki
  • Anneli Widenfalk
  • Gerrit Wolterink
  • Danilo Russo
  • Franz Streissl
  • Christopher Topping
  • EFSA J.2019 Jul;17(7):e05758. EFS25758. doi: 10.2903/j.efsa.2019.5758.Epub 2019-07-29.

Vernonia galamensis ジアシルグリセロールアシルトランスフェラーゼ-1 遺伝子とミオ-イノシトール 1-リン酸合成酵素ノックアウト変異を持つダイズ系統の生成と特性評価

Generation and Characterization of a Soybean Line with a Vernonia galamensis Diacylglycerol Acyltransferase-1 Gene and a myo-Inositol 1-Phosphate Synthase Knockout Mutation.
  • Maythem Al-Amery
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  • Elizabeth Maghirang
  • Kai Su
  • Julia de Melo
  • Feng-Jie Yuan
  • Qing-Yao Shu
  • David Hildebrand
  • Lipids.2020 Jun;doi: 10.1002/lipd.12253.Epub 2020-06-15.

3つの前臨床動物モデルとヒトの脾臓における抗レトロウイルス薬の浸透と薬物トランスポーター濃度

Antiretroviral penetration and drug transporter concentrations in the spleens of three preclinical animal models and humans.
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  • Kimberly Blake
  • Craig Sykes
  • Martina Kovarova
  • Lourdes Adamson
  • Leila Remling-Mulder
  • Paul Luciw
  • J Victor Garcia
  • Ramesh Akkina
  • Jason R Pirone
  • Philip C Smith
  • Angela D M Kashuba
  • Antimicrob. Agents Chemother..2020 Jul;AAC.01384-20. doi: 10.1128/AAC.01384-20.Epub 2020-07-13.

アシュケナージ・ユダヤ人に優勢なまれなTP53突然変異は、複数の癌のリスクをもたらします

A rare TP53 mutation predominant in Ashkenazi Jews confers risk of multiple cancers.
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  • Gregory Kelly
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  • Carolyn Fein Levy
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  • Cancer Res..2020 Jul;canres.1390.2020. doi: 10.1158/0008-5472.CAN-20-1390.Epub 2020-07-16.

モノおよびビスアルキル化ルーマジン増感剤。合成、分子軌道理論、求核性指数、光化学的研究

Mono- and Bis-Alkylated Lumazine Sensitizers: Synthetic, Molecular Orbital Theory, Nucleophilic Index, and Photochemical Studies.
  • María José Sosa
  • María Noel Urrutia
  • Patricia L Schilardi
  • Matías I Quindt
  • Sergio Bonesi
  • Dobrushe Denburg
  • Mariana Vignoni
  • Alexander Greer
  • Edyta M Greer
  • Andrés H Thomas
  • Photochem. Photobiol..2020 Jul;doi: 10.1111/php.13310.Epub 2020-07-06.

白血病治療薬シタラビンのオーダーメイドレセプターを集積した高分子塩ビ膜センサーを用いた新規電位差測定法の検証

Validation of a Novel Potentiometric Method Based on a Polymeric PVC Membrane Sensor Integrated with Tailored Receptors for the Antileukemia Drug Cytarabine.
  • Ayman H Kamel
  • Abd El-Galil E Amr
  • Nashwa H Ashmawy
  • Hoda R Galal
  • Abdulrahman A Almehizia
  • Teraze A Youssef
  • Mohamed A Al-Omar
  • Ahmed Y A Sayed
  • Polymers (Basel).2020 Jun;12(6). E1343. doi: 10.3390/polym12061343.Epub 2020-06-14.

アニリンに選択的なユーロピウム(III)金属-有機フレームワークのセンシング機構の解明。多元配置計算による理論的洞察

Sensing mechanism elucidation of a europium(III) metal-organic framework selective to aniline: A theoretical insight by means of multiconfigurational calculations.
  • Yoan Hidalgo-Rosa
  • Manuel A Treto-Suárez
  • Eduardo Schott
  • Ximena Zarate
  • Dayán Páez-Hernández
  • J Comput Chem.2020 Aug;41(22):1956-1964. doi: 10.1002/jcc.26365.Epub 2020-06-19.

帝王切開分娩のための二重催吐および低用量の神経麻酔モルヒネ投与後の分娩後の悪心および嘔吐のプロスペクティブな評価

[PROSPECTIVE INVESTIGATION OF POSTOPERATIVE NAUSEA AND VOMITING FOLLOWING DUAL PROPHYLAXIS AND LOW DOSE NEURAXIAL MORPHINE FOR CESAREAN DELIVERY].
  • Sharon Orbach-Zinger
  • Iliye Obibok
  • Atara Davis
  • Eitan Razinsky
  • Shlomo Fireman
  • Alexander Ioscovich
  • Anat Shmueli
  • Avi Ben Haroush
  • Lenoid A Eidelman
  • Carolyn F Weiniger
  • Harefuah.2020 Jun;159(6):423-428.

COVID-19 精神科疾患の入院患者。コンサルテーション・リエゾン精神医学の専門家チームによる実際の臨床上の推奨事項

COVID-19 inpatients with psychiatric disorders: Real-world clinical recommendations from an expert team in consultation-liaison psychiatry.
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  • J Affect Disord.2020 09;274:1062-1067. S0165-0327(20)31272-6. doi: 10.1016/j.jad.2020.05.149.Epub 2020-06-01.

実施科学をより迅速にする：退役軍人保健局における5つの保健サービス研究プロジェクトにおける中間コース適応のためのRE-AIMフレームワークの使用

Making Implementation Science More Rapid: Use of the RE-AIM Framework for Mid-Course Adaptations Across Five Health Services Research Projects in the Veterans Health Administration.
  • Russell E Glasgow
  • Catherine Battaglia
  • Marina McCreight
  • Roman Aydiko Ayele
  • Borsika Adrienn Rabin
  • Front Public Health.2020;8:194. doi: 10.3389/fpubh.2020.00194.Epub 2020-05-27.

経皮的バルーン心膜切開術：進行した腫瘍性疾患と重度の心嚢液貯留の患者に選択される治療法

Percutaneous balloon pericardiotomy: Treatment of choice in patients with advanced oncological disease and severe pericardial effusion.
  • Francisco Javier Irazusta
  • Santiago Jiménez-Valero
  • Daniele Gemma
  • Pablo Meras
  • Guillermo Galeote
  • Angel Sanchez-Recalde
  • Veronica Rial
  • Raul Moreno
  • Jose Luis Lopez-Sendon
  • Cardiovasc Revasc Med.2017 Jul - Aug;18(5S1):S14-S17. S1553-8389(17)30113-6. doi: 10.1016/j.carrev.2017.03.029.Epub 2017-04-04.

Culex quinquefasciatus mosquito D7 唾液タンパク質による ADP 結合は、哺乳類の採血を促進する

ADP binding by the Culex quinquefasciatus mosquito D7 salivary protein enhances blood feeding on mammals.
  • Ines Martin-Martin
  • Andrew Paige
  • Paola Carolina Valenzuela Leon
  • Apostolos G Gittis
  • Olivia Kern
  • Brian Bonilla
  • Andrezza Campos Chagas
  • Sundar Ganesan
  • Leticia Barion Smith
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  • Eric Calvo
  • Nat Commun.2020 Jun;11(1):2911. 10.1038/s41467-020-16665-z. doi: 10.1038/s41467-020-16665-z.Epub 2020-06-09.

モリンダ・シトリフォリア・リン葉エキスには抗酸化作用があり、侵害受容行動や白血球の遊走を抑制します

Morinda citrifolia Linn leaf extract possesses antioxidant activities and reduces nociceptive behavior and leukocyte migration.
  • Mairim Russo Serafini
  • Rodrigo Correia Santos
  • Adriana Gibara Guimarães
  • João Paulo Almeida Dos Santos
  • Alan Diego da Conceicão Santos
  • Izabel Almeida Alves
  • Daniel Pens Gelain
  • Paulo Cesar de Lima Nogueira
  • Lucindo José Quintans-Júnior
  • Leonardo Rigoldi Bonjardim
  • Adriano Antunes de Souza Araújo
  • J Med Food.2011 Oct;14(10):1159-66. doi: 10.1089/jmf.2010.0254.Epub 2011-05-06.

2型糖尿病患者における神経障害、神経障害性疼痛、運動恐怖症の予測と人工知能を用いたコンピュータ化された臨床意思決定支援システムの設計

Prediction of neuropathy, neuropathic pain and kinesiophobia in patients with type 2 diabetes and design of computerized clinical decision support systems by using artificial intelligence.
  • Filiz Ozdemir
  • Ali Ari
  • Melek Havva Kilcik
  • Davut Hanbay
  • Ibrahim Sahin
  • Med. Hypotheses.2020 Jul;143:110070. S0306-9877(20)31510-3. doi: 10.1016/j.mehy.2020.110070.Epub 2020-07-05.

原始歯の修復物交換の決定に及ぼす臨床的基準の違いの影響

Influence of different clinical criteria on the decision to replace restorations in primary teeth.
  • Bruna Lorena Pereira Moro
  • Raiza Dias Freitas
  • Laura Regina Antunes Pontes
  • Ana Laura Pássaro
  • Tathiane Larissa Lenzi
  • Tamara Kerber Tedesco
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  • Daniela Prócida Raggio
  • Maximiliano Sérgio Cenci
  • Fausto Medeiros Mendes
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網膜静脈閉塞性浮腫の治療におけるデキサメタゾンインプラントと抗VEGF薬の比較：メタアナリシスとシステマティックレビュー

Comparison of intravitreal dexamethasone implant and anti-VEGF drugs in the treatment of retinal vein occlusion-induced oedema: a meta-analysis and systematic review.
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  • Kunpeng Xie
  • Mingzhu Yang
  • Huijuan He
  • Ya Li
  • Bo Lei
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重症SARSのCoV-2病に対する治療的血漿交換のパイロット研究（COVID-19）。無作為化比較試験の研究プロトコルの構造化された要約

A pilot study of therapeutic plasma exchange for serious SARS CoV-2 disease (COVID-19): A structured summary of a randomized controlled trial study protocol.
  • Fahad Faqihi
  • Abdulrahman Alharthy
  • Mohammed Alodat
  • Daood Asad
  • Waleed Aletreby
  • Demetrios J Kutsogiannis
  • Peter G Brindley
  • Dimitrios Karakitsos
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慢性特発性軸索性多発神経障害（CIAP）患者のパフォーマンスと自己報告機能：4年間の追跡調査

Performance and self-reported functioning of people with Chronic Idiopathic Axonal Polyneuropathy (CIAP): a four year follow up study.
  • Karlijn van Oeijen
  • Laurien L Teunissen
  • Christel van Leeuwen
  • Marleen van Opstal
  • Marie José van der Putten
  • Nicolette C Notermans
  • Nico L U van Meeteren
  • Carin D Schröder
  • Arch Phys Med Rehabil.2020 Jul;S0003-9993(20)30432-9. doi: 10.1016/j.apmr.2020.06.017.Epub 2020-07-16.

グリーン吸着剤であるナッツシェルによる水溶液からのPb(II)吸着。吸着研究,再生研究,スケールアップ設計,生物学的指標への影響,MLRモデリング

Pb(II) adsorption from aqueous solution by nutshells, green adsorbent: Adsorption studies, regeneration studies, scale-up design, its effect on biological indicator and MLR modeling.
  • Abhishek Das
  • Nirjhar Bar
  • Sudip Kumar Das
  • J Colloid Interface Sci.2020 Jul;580:245-255. S0021-9797(20)30895-X. doi: 10.1016/j.jcis.2020.07.017.Epub 2020-07-12.

オートファジーに依存しないリソソーム経路を介してHFD誘発性肥満、高脂血症、インスリン抵抗性を改善する強力なSCAP分解剤の発見

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
  • Zu-Guo Zheng
  • Si-Tong Zhu
  • Hui-Min Cheng
  • Xin Zhang
  • Gang Cheng
  • Pyone Myat Thu
  • Supeng Perry Wang
  • Hui-Jun Li
  • Ming Ding
  • Lei Qiang
  • Xiao-Wei Chen
  • Qing Zhong
  • Ping Li
  • Xiaojun Xu
  • Autophagy.2020 May;:1-22. doi: 10.1080/15548627.2020.1757955.Epub 2020-05-20.

活性型両親媒性物質を有効な安定化剤として用いたナノ化一本鎖RNAベースアジュバントの開発抗原提示細胞の活性化による体液性免疫応答の誘導

Nanoformulated Single-Stranded RNA-Based Adjuvant with a Coordinative Amphiphile as an Effective Stabilizer: Inducing Humoral Immune Response by Activation of Antigen-Presenting Cells.
  • Hyo-Jung Park
  • Eun-Kyoung Bang
  • Jung Joo Hong
  • Sang-Myeong Lee
  • Hae Li Ko
  • Hye Won Kwak
  • Hyelim Park
  • Kyung Won Kang
  • Rhoon-Ho Kim
  • Seung Rok Ryu
  • Green Kim
  • Hanseul Oh
  • Hye-Jung Kim
  • Kyuri Lee
  • Minjeong Kim
  • Soo Young Kim
  • Jae-Ouk Kim
  • Karim El-Baz
  • Hyukjin Lee
  • Manki Song
  • Dae Gwin Jeong
  • Gyochang Keum
  • Jae-Hwan Nam
  • Angew. Chem. Int. Ed. Engl..2020 Jul;59(28):11540-11549. doi: 10.1002/anie.202002979.Epub 2020-05-08.

薬用植物（Teucrium arduini L.およびTeucrium flavum L.）のポリフェノール含有量との関連での遺伝毒性および細胞毒性特性

Genotoxic and cytotoxic properties of two medical plants (Teucrium arduini L.and Teucrium flavum L.) in relation to their polyphenolic contents.
  • Darko Grujičić
  • Aleksandra Marković
  • Jovana Tubić Vukajlović
  • Milan Stanković
  • Marina Radović Jakovljević
  • Andrija Ćirić
  • Katarina Djordjević
  • Nevena Planojević
  • Milena Milutinović
  • Olivera Milošević-Djordjević
  • Mutat. Res..2020 04;852:503168. S1383-5718(20)30038-3. doi: 10.1016/j.mrgentox.2020.503168.Epub 2020-03-12.

片側性水腎症の小児における尿細管間質性線維症のバイオマーカーとしての金属マトリックスメタロプロテアーゼおよびメタロプロテアーゼの組織阻害剤の選択

Selected Metal Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases as Potential Biomarkers for Tubulointerstitial Fibrosis in Children with Unilateral Hydronephrosis.
  • Beata Bieniaś
  • Przemysław Sikora
  • Dis. Markers.2020;2020:9520309. doi: 10.1155/2020/9520309.Epub 2020-06-29.

CD200は膵臓腫瘍の微小環境における免疫抑制を促進する

CD200 promotes immunosuppression in the pancreatic tumor microenvironment.
  • Fouad Choueiry
  • Molly Torok
  • Reena Shakya
  • Kriti Agrawal
  • Anna Deems
  • Brooke Benner
  • Alice Hinton
  • Jami Shaffer
  • Bradley W Blaser
  • Anne M Noonan
  • Terence M Williams
  • Mary Dillhoff
  • Darwin L Conwell
  • Phil A Hart
  • Zobeida Cruz-Monserrate
  • Xue-Feng Bai
  • William E Carson
  • Thomas A Mace
  • J Immunother Cancer.2020 06;8(1). e000189. doi: 10.1136/jitc-2019-000189.Epub 2020-06-23.

鼠径ヘルニアの開腹メッシュヘルニア形成術（OMH）、腹腔鏡下完全腹膜外（TEP）、経腹膜前腹膜（TAPP）修復術後の性機能と受胎可能性の指標を比較するための3群無作為化研究

A three-arm randomized study to compare sexual functions and fertility indices following open mesh hernioplasty (OMH), laparoscopic totally extra peritoneal (TEP) and transabdominal preperitoneal (TAPP) repair of groin hernia.
  • Shardool Gupta
  • Asuri Krishna
  • Mayank Jain
  • Ankur Goyal
  • Atin Kumar
  • Pradeep Chaturvedi
  • Rajesh Sagar
  • Rashmi Ramachandran
  • Om Prakash
  • Subodh Kumar
  • V Seenu
  • Virinder Bansal
  • Surg Endosc.2020 Jun;10.1007/s00464-020-07697-z. doi: 10.1007/s00464-020-07697-z.Epub 2020-06-15.

細菌性膣炎の臨床基準によって分類されたサンプル群における膣マイクロバイオームの変化

Vaginal microbiome variances in sample groups categorized by clinical criteria of bacterial vaginosis.
  • Hui-Mei Chen
  • Tzu-Hao Chang
  • Feng-Mao Lin
  • Chao Liang
  • Chih-Min Chiu
  • Tzu-Ling Yang
  • Ting Yang
  • Chia-Yen Huang
  • Yeong-Nan Cheng
  • Yi-An Chang
  • Po-Ya Chang
  • Shun-Long Weng
  • BMC Genomics.2018 Dec;19(Suppl 10):876. 10.1186/s12864-018-5284-7. doi: 10.1186/s12864-018-5284-7.Epub 2018-12-31.

ツンジ病に特に重点を置いた表皮寄生性皮膚疾患の治療におけるジメチコンの有効性と安全性：エビデンスに基づいた批判的レビュー

Efficacy and safety of dimeticones in the treatment of epidermal parasitic skin diseases with special emphasis on tungiasis: an evidence-based critical review.
  • Hollman Miller
  • Julián Trujillo-Trujillo
  • Francis Mutebi
  • Hermann Feldmeier
  • Braz J Infect Dis.2020 Mar - Apr;24(2):170-177. S1413-8670(20)30018-0. doi: 10.1016/j.bjid.2020.01.004.Epub 2020-02-24.

南インド人集団におけるてんかん患者におけるカルバマゼピンの用量調整血漿中濃度に及ぼすチトクロームP450 3A5（CYP3A5）遺伝子多型の影響

Influence of cytochrome P450 3A5 (CYP3A5) genetic polymorphism on dose-adjusted plasma levels of carbamazepine in epileptic patients in South Indian population.
  • Mahalakshmi Ganesapandian
  • Kesavan Ramasamy
  • Surendiran Adithan
  • Sunil K Narayan
  • Indian J Pharmacol.2019 Nov-Dec;51(6):384-388. IJPharm-51-384. doi: 10.4103/ijp.IJP_122_19.Epub 2020-01-16.

計算科学的ケモゲノミクスの薬物リポジショニング戦略は、抗マラリア薬の新たな再利用ヒット薬としてエピルビシンを発見することを可能にしています

Computational chemogenomics drug repositioning strategy enables the discovery of Epirubicin as a new repurposed hit for and .
  • Letícia Tiburcio Ferreira
  • Juliana Rodrigues
  • Gustavo Capatti Cassiano
  • Tatyana Almeida Tavella
  • Kaira Cristina Peralis Tomaz
  • Djane Clarys Baia-da-Silva
  • Macejane Ferreira Souza
  • Marilia Nunes do Nascimento Lima
  • Melina Mottin
  • Ludimila Dias Almeida
  • Juliana Calit
  • Maria Carolina Silva de Barros Puça
  • Gisely Cardoso Melo
  • Daniel Youssef Bargieri
  • Stefanie Costa Pinto Lopes
  • Marcus Vinicius Guimarães Lacerda
  • Elizabeth Bilsland
  • Per Sunnerhagen
  • Bruno Junior Neves
  • Carolina Horta Andrade
  • Pedro Vitor Lemos Cravo
  • Fabio Trindade Maranhão Costa
  • Antimicrob. Agents Chemother..2020 Jun;AAC.02041-19. doi: 10.1128/AAC.02041-19.Epub 2020-06-29.

オーロラB特異性スイッチは、メタフェース/アナフェース転移時の非接合を保護するために必要とされる

The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition.
  • Joanna R Kelly
  • Silvia Martini
  • Nicola Brownlow
  • Dhira Joshi
  • Stefania Federico
  • Shirin Jamshidi
  • Svend Kjaer
  • Nicola Lockwood
  • Khondaker Miraz Rahman
  • Franca Fraternali
  • Peter J Parker
  • Tanya N Soliman
  • Nat Commun.2020 03;11(1):1396. 10.1038/s41467-020-15163-6. doi: 10.1038/s41467-020-15163-6.Epub 2020-03-13.

澱粉分岐酵素IIbの弱から強への欠損効果は、アミロース伸長性トウモロコシの内胚乳において二相性澱粉顆粒の形成を誘導する

The defective effect of starch branching enzyme IIb from weak to strong induces the formation of biphasic starch granules in amylose-extender maize endosperm.
  • Wei He
  • Xiangguo Liu
  • Lingshang Lin
  • Ahui Xu
  • Dongyun Hao
  • Cunxu Wei
  • Plant Mol. Biol..2020 Jun;103(3):355-371. 10.1007/s11103-020-00998-w. doi: 10.1007/s11103-020-00998-w.Epub 2020-03-19.

ウサギの肝臓における超音波キャビテーションの病理学的、生化学的、血液学的、組織学的効果

Hepathic, biochemical, hematological, and histological effects of the ultracavitation in rabbits livers.
  • Patrícia Froes Meyer
  • Janiele Ferreira da Silva Sousa
  • Rejane Vilar da Rocha
  • José Queiroz Filho
  • Oscar Ariel Ronzio
  • Rodrigo Marcel Valentim da Silva
  • Ana Camila de Medeiros Manso
  • Afra Rafaelli Magalhães de Almeida
  • Camila Procopio Andrada
  • Acta Cir Bras.2020;35(4):e202000403. S0102-86502020000400205. doi: 10.1590/s0102-865020200040000003.Epub 2020-06-19.

アピキサバンは尿毒症における内皮機能障害のin vitroモデルにおいて内皮の炎症性およびプロトロンボティック表現型をダウンレギュレートすることを明らかにした

Apixaban Downregulates Endothelial Inflammatory and Prothrombotic Phenotype in an In Vitro Model of Endothelial Dysfunction in Uremia.
  • Sergi Torramade-Moix
  • Marta Palomo
  • Manel Vera
  • Didac Jerez
  • Ana Belen Moreno-Castaño
  • M Urooj Zafar
  • Jordi Rovira
  • Fritz Diekmann
  • Joan Carles Garcia-Pagan
  • Gines Escolar
  • Aleix Cases
  • Maribel Diaz-Ricart
  • Cardiovasc Drugs Ther.2020 Jul;10.1007/s10557-020-07010-z. doi: 10.1007/s10557-020-07010-z.Epub 2020-07-10.

全ゲノム塩基配列解析により、自閉症スペクトラム障害と骨格に問題のあるイラン人家族における3つの候補ホモ接合体バリアントを同定した

Whole-Exome Sequencing Identifies Three Candidate Homozygous Variants in a Consanguineous Iranian Family with Autism Spectrum Disorder and Skeletal Problems.
  • Saeed Farajzadeh Valilou
  • Afagh Alavi
  • Mahdiyeh Pashaei
  • Saghar Ghasemi Firouzabadi
  • Yousef Shafeghati
  • Ahoura Nozari
  • Fatemeh Hadipour
  • Zahra Hadipour
  • Bijan Maghsoodlou Estrabadi
  • Seyed Gholamreza Noorazar
  • Susan Banihashemi
  • Javad Karimian
  • Mahshid Fattahi
  • Farkhondeh Behjati
  • Mol Syndromol.2020 Jun;11(2):62-72. msy-0011-0062. doi: 10.1159/000506530.Epub 2020-03-11.

イランの高齢者におけるオステオサルコペニアの有病率と心血管リスク因子との関連。ブシェール高齢者保健（BEH）プログラム

Prevalence of Osteosarcopenia and Its Association with Cardiovascular Risk Factors in Iranian Older People: Bushehr Elderly Health (BEH) Program.
  • Noushin Fahimfar
  • Farbod Zahedi Tajrishi
  • Safoora Gharibzadeh
  • Gita Shafiee
  • Kiarash Tanha
  • Ramin Heshmat
  • Iraj Nabipour
  • Alireza Raeisi
  • Ali Jalili
  • Bagher Larijani
  • Afshin Ostovar
  • Calcif. Tissue Int..2020 Apr;106(4):364-370. 10.1007/s00223-019-00646-6. doi: 10.1007/s00223-019-00646-6.Epub 2019-12-17.

腫瘍学的環境での同軸肝生検と非同軸肝生検の比較：診断収率、合併症、播種リスク

Comparison of a coaxial versus non-coaxial liver biopsy technique in an oncological setting: diagnostic yield, complications and seeding risk.
  • Nicos Fotiadis
  • Katja N De Paepe
  • Lawrence Bonne
  • Nasir Khan
  • Angela Riddell
  • Nicholas Turner
  • Naureen Starling
  • Marco Gerlinger
  • Sheela Rao
  • Ian Chau
  • David Cunningham
  • Dow-Mu Koh
  • Eur Radiol.2020 Jul;10.1007/s00330-020-07038-7. doi: 10.1007/s00330-020-07038-7.Epub 2020-07-14.

3dMD顔面解析とセファロメトリーを用いた第II類下顎後退症患者におけるアクチベーター・アプライアンスの効果について、思春期と思春期以降の時期を比較した前向き研究

A Prospective Study Comparing Adolescent and Post-Adolescent Periods Regarding Effects of Activator Appliance in Patients with Class II Mandibular Retrognathia by Using 3dMDface Analysis and Cephalometry.
  • Esra Yüksel Coşkun
  • Elçin Esenlik
  • Med. Sci. Monit..2020 Jun;26:e921401. 921401. doi: 10.12659/MSM.921401.Epub 2020-06-26.

癌細胞におけるMOAP-1, Bax, RASSF1Aの三位一体発現は、MOAP-1のBH3Lドメインを必要とする化学増感を促進する

Tricistronic expression of MOAP-1, Bax and RASSF1A in cancer cells enhances chemo-sensitization that requires BH3L domain of MOAP-1.
  • Yong Hoi Lee
  • Siew Wai Pang
  • Esther Revai Lechtich
  • Khalid Shah
  • Samson Eugin Simon
  • Suriyan Ponnusamy
  • Ramesh Narayanan
  • Chit Laa Poh
  • Kuan Onn Tan
  • J. Cancer Res. Clin. Oncol..2020 Jul;146(7):1751-1764. 10.1007/s00432-020-03231-9. doi: 10.1007/s00432-020-03231-9.Epub 2020-05-06.

ソニックヘッジホッグシグナル伝達アゴニスト（SAG）はBDNFの分泌を誘発し、生後ラット海馬におけるGABA作動性ネットワークの成熟を促進する

Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus.
  • Quentin Delmotte
  • Diabe Diabira
  • Yasmine Belaidouni
  • Mira Hamze
  • Marine Kochmann
  • Aurélie Montheil
  • Jean-Luc Gaiarsa
  • Christophe Porcher
  • Yesser H Belgacem
  • Front Cell Neurosci.2020;14:98. doi: 10.3389/fncel.2020.00098.Epub 2020-04-23.

肝移植患者におけるタクロリムスの薬理遺伝学的-全血および細胞内薬物動態-薬力学的（PG-PK2-PD）関係

Pharmacogenetic-Whole blood and intracellular pharmacokinetic-Pharmacodynamic (PG-PK2-PD) relationship of tacrolimus in liver transplant recipients.
  • Camille Tron
  • Jean-Baptiste Woillard
  • Pauline Houssel-Debry
  • Véronique David
  • Caroline Jezequel
  • Michel Rayar
  • David Balakirouchenane
  • Benoit Blanchet
  • Jean Debord
  • Antoine Petitcollin
  • Mickaël Roussel
  • Marie-Clémence Verdier
  • Eric Bellissant
  • Florian Lemaitre
  • PLoS ONE.2020;15(3):e0230195. PONE-D-19-21120. doi: 10.1371/journal.pone.0230195.Epub 2020-03-12.

血縁関係のないデュシェンヌ型筋ジストロフィー患者961人の包括的な遺伝子解析。診断、予防、治療の可能性に焦点を当てる

Comprehensive genetic analysis of 961 unrelated Duchenne Muscular Dystrophy patients: Focus on diagnosis, prevention and therapeutic possibilities.
  • Shalini H Kumar
  • Kalpana Athimoolam
  • Manikandan Suraj
  • Mary Shoba Das Christu Das
  • Aparna Muralidharan
  • Divya Jeyam
  • Jaicy Ashokan
  • Priya Karthikeyan
  • Ragav Krishna
  • Arati Khanna-Gupta
  • Lakshmi Bremadesam Raman
  • PLoS ONE.2020;15(6):e0232654. PONE-D-19-13901. doi: 10.1371/journal.pone.0232654.Epub 2020-06-19.

シタグリプチンは糖尿病患者における心筋梗塞後の心血管死や心不全による入院のリスクを低下させない：TECOSからの観察

Sitagliptin does not reduce the risk of cardiovascular death or hospitalization for heart failure following myocardial infarction in patients with diabetes: observations from TECOS.
  • Michael A Nauck
  • Darren K McGuire
  • Karen S Pieper
  • Yuliya Lokhnygina
  • Timo E Strandberg
  • Axel Riefflin
  • Tuncay Delibasi
  • Eric D Peterson
  • Harvey D White
  • Russell Scott
  • Rury R Holman
  • Cardiovasc Diabetol.2019 09;18(1):116. 10.1186/s12933-019-0921-2. doi: 10.1186/s12933-019-0921-2.Epub 2019-09-03.

内視鏡検査で診断されたWhipple病：コロンビアにおける初の未診断疾患の症例報告と文献レビュー

Whipple disease diagnosed by enteroscopy: first case report in Colombia of an underdiagnosed disease and literature review.
  • Margarita Rey R
  • Luis Alejandro Orozco
  • Katherine Marrugo
  • Rocio López
  • Erika D Pérez-Riveros
  • José De la Hoz-Valle
  • Fernando Sierra-Arango
  • BMC Gastroenterol.2020 Jun;20(1):197. 10.1186/s12876-020-01302-2. doi: 10.1186/s12876-020-01302-2.Epub 2020-06-23.

β-アレスチン2は、下垂体腫瘍におけるAKTリン酸化および細胞増殖に対するドパミン受容体2型阻害作用に必要である

β-arrestin 2 is required for dopamine receptor type 2 inhibitory effects on AKT phosphorylation and cell proliferation in pituitary tumors.
  • Federica Mangili
  • Elena Giardino
  • Donatella Treppiedi
  • Anna Maria Barbieri
  • Rosa Catalano
  • Marco Locatelli
  • Andrea Gerardo Lania
  • Anna Spada
  • Maura Arosio
  • Giovanna Mantovani
  • Erika Peverelli
  • Neuroendocrinology.2020 Jun;000509219. doi: 10.1159/000509219.Epub 2020-06-08.

バルバスFritillaria cirrhosaの水性抽出物は、ヒト大腸上皮NCM460細胞における溝の侵入を阻害することでサイトカインシスの失敗を誘導する

Aqueous extract of bulbus Fritillaria cirrhosa induces cytokinesis failure by blocking furrow ingression in human colon epithelial NCM460 cells.
  • Xihan Guo
  • Xiayu Wu
  • Juan Ni
  • Ling Zhang
  • Jinglun Xue
  • Xu Wang
  • Mutat. Res..2020 Feb - Mar;850-851:503147. S1383-5718(20)30017-6. doi: 10.1016/j.mrgentox.2020.503147.Epub 2020-01-25.

尿中エクソソームに含まれるホスホエノールピルビン酸カルボキナーゼは、初期のインスリン抵抗性および糖尿病における腎グルコース新生の障害を反映している

Phosphoenolpyruvate carboxykinase in urine exosomes reflect impairment in renal gluconeogenesis in early insulin resistance and diabetes.
  • Rajni Sharma
  • Manju Kumari
  • Prem Prakash
  • Sushil Gupta
  • Swasti Tiwari
  • Am. J. Physiol. Renal Physiol..2020 03;318(3):F720-F731. doi: 10.1152/ajprenal.00507.2019.Epub 2020-02-10.

バイオベース包装。材料、修飾、産業応用と持続可能性

Bio-Based Packaging: Materials, Modifications, Industrial Applications and Sustainability.
  • Corina L Reichert
  • Elodie Bugnicourt
  • Maria-Beatrice Coltelli
  • Patrizia Cinelli
  • Andrea Lazzeri
  • Ilaria Canesi
  • Francesca Braca
  • Belén Monje Martínez
  • Rafael Alonso
  • Lodovico Agostinis
  • Steven Verstichel
  • Lasse Six
  • Steven De Mets
  • Elena Cantos Gómez
  • Constance Ißbrücker
  • Ruben Geerinck
  • David F Nettleton
  • Inmaculada Campos
  • Erik Sauter
  • Pascal Pieczyk
  • Markus Schmid
  • Polymers (Basel).2020 Jul;12(7). E1558. doi: 10.3390/polym12071558.Epub 2020-07-14.

化学的に誘導された異能性の標的とメカニズム。発がん性および遺伝性疾患に対するアニュージェンのリスク評価に関する2017年IWGTワークグループの報告書の第1部

Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.
  • Anthony M Lynch
  • David Eastmond
  • Azeddine Elhajouji
  • Roland Froetschl
  • Micheline Kirsch-Volders
  • Francesco Marchetti
  • Kenichi Masumura
  • Francesca Pacchierotti
  • Maik Schuler
  • David Tweats
  • Mutat. Res..2019 11;847:403025. S1383-5718(18)30412-1. doi: 10.1016/j.mrgentox.2019.02.006.Epub 2019-03-02.

超音波生検後に診断された乳癌に対する造影スペクトラルマンモグラフィの術前評価：造影磁気共鳴画像との相関と術後5年経過観察

Preoperative assessment of contrast-enhanced spectral mammography of diagnosed breast cancers after sonographic biopsy: Correlation to contrast-enhanced magnetic resonance imaging and 5-year postoperative follow-up.
  • Yun-Chung Cheung
  • Yu-Hsiang Juan
  • Yung-Feng Lo
  • Yu-Ching Lin
  • Chih-Hua Yeh
  • Shir-Hwa Ueng
  • Medicine (Baltimore).2020 Jan;99(5):e19024. 00005792-202001310-00095. doi: 10.1097/MD.0000000000019024.

イネ科の穀物・薬用作物であるソフトシェルテッド・アドレイ（品種）のゲノムアセンブリーとアノテーション

Genome Assembly and Annotation of Soft-Shelled Adlay ( Variety ), a Cereal and Medicinal Crop in the Poaceae Family.
  • Sang-Ho Kang
  • Byeollee Kim
  • Beom-Soon Choi
  • Hyun Oh Lee
  • Nam-Hoon Kim
  • Seung Jae Lee
  • Hye Sik Kim
  • Myung Ju Shin
  • Hyo-Won Kim
  • Kyunghyun Nam
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歯内療法治療中の滑動軌跡運動学が術中および術後疼痛の発生と強度に及ぼす影響：無作為化臨床試験のシステマティックレビュー

Influence of glide path kinematics during endodontic treatment on the occurrence and intensity of intraoperative and postoperative pain: a systematic review of randomized clinical trials.
  • Thaís Christina Cunha
  • Felipe de Souza Matos
  • Luiz Renato Paranhos
  • Ítalo de Macedo Bernardino
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アンハイドロビオシスのカビ類であるPolypedilum vanderplankiの乾燥耐性に関連する膜貫通タンパク質の新しいグループ

New group of transmembrane proteins associated with desiccation tolerance in the anhydrobiotic midge Polypedilum vanderplanki.
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  • Sci Rep.2020 Jul;10(1):11633. 10.1038/s41598-020-68330-6. doi: 10.1038/s41598-020-68330-6.Epub 2020-07-15.

MYC駆動癌の管理のための治療戦略としてのプロテインホスファターゼ2A活性化

Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers.
  • Caroline C Farrington
  • Eric Yuan
  • Sahar Mazhar
  • Sudeh Izadmehr
  • Lauren Hurst
  • Brittany L Allen-Petersen
  • Mahnaz Janghorban
  • Eric Chung
  • Grace Wolczanski
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HIV陽性でオプションBに登録されている妊娠中および授乳中の女性におけるトイレアクセスが抗レトロウイルス薬のアドヒアランス意図に及ぼす影響

Influence of toilet access on antiretroviral adherence intention among pregnant and breastfeeding women who are HIV-positive and enrolled in Option B.
  • Jerry John Nutor
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  • Shannon P Marquez
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  • Health Care Women Int.2020 Apr;:1-15. doi: 10.1080/07399332.2020.1746791.Epub 2020-04-02.

一過性脳虚血性脳卒中後のプロゲステロンの経鼻投与は、死亡率を低下させ、神経保護を提供する

Intranasal delivery of progesterone after transient ischemic stroke decreases mortality and provides neuroprotection.
  • Magalie Fréchou
  • Shaodong Zhang
  • Philippe Liere
  • Brigitte Delespierre
  • Nouha Soyed
  • Antoine Pianos
  • Michael Schumacher
  • Claudia Mattern
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  • Neuropharmacology.2015 Oct;97:394-403. S0028-3908(15)00258-0. doi: 10.1016/j.neuropharm.2015.06.002.Epub 2015-06-14.

哺乳類の重要なコレステロール合成酵素であるスクワレンモノオキシゲナーゼは、その基質によってアロステリックに安定化されています

A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate.
  • Hiromasa Yoshioka
  • Hudson W Coates
  • Ngee Kiat Chua
  • Yuichi Hashimoto
  • Andrew J Brown
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  • Proc. Natl. Acad. Sci. U.S.A..2020 03;117(13):7150-7158. 1915923117. doi: 10.1073/pnas.1915923117.Epub 2020-03-13.

クレアチニンは、トレーニングを受けていない人がどのようにフィットネストレーニング負荷に適応しているかを評価するための生化学的マーカーです

Creatinine is a biochemical marker for assessing how untrained people adapt to fitness training loads.
  • Andrii Chernozub
  • Vladimir Potop
  • Georgiy Korobeynikov
  • Olivia Carmen Timnea
  • Oleg Dubachinskiy
  • Oksana Ikkert
  • Yuriy Briskin
  • Yuriy Boretsky
  • Lesia Korobeynikova
  • PeerJ.2020;8:e9137. 9137. doi: 10.7717/peerj.9137.Epub 2020-05-22.

重症Orientia tsutsugamushi感染時の肺炎症とTie2/angiopoietin介在性内皮機能障害の極性化

Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection.
  • Brandon Trent
  • Yuejin Liang
  • Yan Xing
  • Marisol Esqueda
  • Yang Wei
  • Nam-Hyuk Cho
  • Hong-Il Kim
  • Yeon-Sook Kim
  • Thomas R Shelite
  • Jiyang Cai
  • Jiaren Sun
  • Donald H Bouyer
  • Jinjun Liu
  • Lynn Soong
  • PLoS Negl Trop Dis.2020 03;14(3):e0007675. PNTD-D-19-01266. doi: 10.1371/journal.pntd.0007675.Epub 2020-03-02.

E2F1のアセチル化は、DNA二本鎖切断の修復を促進するために、p300/CBPを介してヒストンのアセチル化を誘導する

E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair.
  • Swarnalatha Manickavinayaham
  • Renier Vélez-Cruz
  • Anup K Biswas
  • Ella Bedford
  • Brianna J Klein
  • Tatiana G Kutateladze
  • Bin Liu
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  • Nat Commun.2019 10;10(1):4951. 10.1038/s41467-019-12861-8. doi: 10.1038/s41467-019-12861-8.Epub 2019-10-30.

マスター転写因子NLP7の一過性のゲノムワイド相互作用が窒素応答カスケードを開始することを明らかにした

Transient genome-wide interactions of the master transcription factor NLP7 initiate a rapid nitrogen-response cascade.
  • José M Alvarez
  • Anna-Lena Schinke
  • Matthew D Brooks
  • Angelo Pasquino
  • Lauriebeth Leonelli
  • Kranthi Varala
  • Alaeddine Safi
  • Gabriel Krouk
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  • Nat Commun.2020 03;11(1):1157. 10.1038/s41467-020-14979-6. doi: 10.1038/s41467-020-14979-6.Epub 2020-03-02.

産科性抗リン脂質症候群における死産の二次予防のための免疫グロブリン静脈内投与．症例シリーズと文献のシステマティックレビュー

Intravenous immunoglobulin for the secondary prevention of stillbirth in obstetric antiphospholipid syndrome: A case series and systematic review of literature.
  • Maria Letizia Urban
  • Alessandra Bettiol
  • Caterina Serena
  • Chiara Comito
  • Irene Turrini
  • Silvia Fruttuoso
  • Elena Silvestri
  • Alfredo Vannacci
  • Claudia Ravaldi
  • Felice Petraglia
  • Giacomo Emmi
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  • Federico Mecacci
  • Autoimmun Rev.2020 Jul;:102620. S1568-9972(20)30187-7. doi: 10.1016/j.autrev.2020.102620.Epub 2020-07-16.

プロゲステロンとcAMPは相乗効果を発揮して、炎症性/労働性刺激に対する子宮筋膜細胞の反応性を抑制する

Progesterone and cAMP synergize to inhibit responsiveness of myometrial cells to pro-inflammatory/pro-labor stimuli.
  • Peyvand Amini
  • Rachel Wilson
  • Junye Wang
  • Huiqing Tan
  • Lijuan Yi
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  • Zachary Stanfield
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  • Sam Mesiano
  • Mol. Cell. Endocrinol..2019 01;479:1-11. S0303-7207(18)30240-5. doi: 10.1016/j.mce.2018.08.005.Epub 2018-08-15.

輸血依存性β-タラセミア重症患者でDeferasirox療法を受けた場合の尿中代謝プロファイル

Urinary Metabolic Profile of Patients with Transfusion-Dependent β-Thalassemia Major Undergoing Deferasirox Therapy.
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  • Miriam Zacchia
  • Amerigo Beneduci
  • Silvia Costantini
  • Patrizia Cinque
  • Anna Spasiano
  • Giuseppina De Luca
  • Maria Enrica Di Pietro
  • Paolo Ricchi
  • Francesco Trepiccione
  • Giovambattista Capasso
  • Aldo Filosa
  • Kidney Blood Press. Res..2020;45(3):455-466. 000507369. doi: 10.1159/000507369.Epub 2020-05-20.

プールされた単細胞遺伝学的スクリーニングは、上皮から間葉系への移行の連続体における制御的チェックポイントを同定する

A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition.
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  • Andrew J Hill
  • Xiaojie Qiu
  • Dana Jackson
  • Jay Shendure
  • Cole Trapnell
  • Nat. Genet..2019 09;51(9):1389-1398. 10.1038/s41588-019-0489-5. doi: 10.1038/s41588-019-0489-5.Epub 2019-09-02.

子どもの虐待に関する世界的な研究動向の書誌学的分析

A Bibliometric Analysis of the Global Research Trend in Child Maltreatment.
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  • Thang Van Pham
  • Giang Hai Ha
  • Anh Toan Ngo
  • Long Hoang Nguyen
  • Thuc Thi Minh Vu
  • Ha Ngoc Do
  • Vu Nguyen
  • Anh Tuan Le Nguyen
  • Tung Thanh Tran
  • Nu Thi Truong
  • Vuong Quan Hoang
  • Tung Manh Ho
  • Nhue Van Dam
  • Thu Trang Vuong
  • Hung Quang Nguyen
  • Huong Thi Le
  • Hoa Thi Do
  • Mackenzie Moir
  • Yoko Shimpuku
  • Meghnath Dhimal
  • Shalini Subash Arya
  • Tu Huu Nguyen
  • Suraj Bhattarai
  • Carl A Latkin
  • Cyrus S H Ho
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  • Int J Environ Res Public Health.2018 07;15(7). E1456. doi: 10.3390/ijerph15071456.Epub 2018-07-10.

上皮成長因子受容体（EGFR）のL858R/T790M変異を有する肺癌に対するプローブとしての放射性ヨウ素化ロシレチニブ（CO-1686）の合成と基礎的評価

Synthesis and Fundamental Evaluation of Radioiodinated Rociletinib (CO-1686) as a Probe to Lung Cancer with L858R/T790M Mutations of Epidermal Growth Factor Receptor (EGFR).
  • Muammar Fawwaz
  • Kenji Mishiro
  • Ryuichi Nishii
  • Izumi Sawazaki
  • Kazuhiro Shiba
  • Seigo Kinuya
  • Kazuma Ogawa
  • Molecules.2020 Jun;25(12). E2914. doi: 10.3390/molecules25122914.Epub 2020-06-24.

ニーマンピック病B型を引き起こすp. (Ala359Asp) SMPD1変異体の疫学的、臨床的、生化学的特徴の検討

Epidemiological, clinical and biochemical characterization of the p.(Ala359Asp) SMPD1 variant causing Niemann-Pick disease type B.
  • Mariana Acuña
  • Pablo Martínez
  • Carol Moraga
  • Xingxuan He
  • Mauricio Moraga
  • Bessie Hunter
  • Peter Nuernberg
  • Rodrigo A Gutiérrez
  • Mauricio González
  • Edward H Schuchman
  • José Luis Santos
  • Juan Francisco Miquel
  • Paulina Mabe
  • Silvana Zanlungo
  • Eur. J. Hum. Genet..2016 Feb;24(2):208-13. ejhg201589. doi: 10.1038/ejhg.2015.89.Epub 2015-04-29.

日本脳炎や西ナイルウイルス感染時のヒト神経細胞モデルプロテオームの比較と、神経病理発生における蚊の唾液の役割の可能性

Comparison of a human neuronal model proteome upon Japanese encephalitis or West Nile Virus infection and potential role of mosquito saliva in neuropathogenesis.
  • Benoit Besson
  • Justine Basset
  • Sandrine Gatellier
  • Hélène Chabrolles
  • Thibault Chaze
  • Véronique Hourdel
  • Mariette Matondo
  • Nathalie Pardigon
  • Valérie Choumet
  • PLoS ONE.2020;15(5):e0232585. PONE-D-19-22706. doi: 10.1371/journal.pone.0232585.Epub 2020-05-06.

子癇前症におけるステロイド産生とアロマターゼ活性の異常

Abnormal steroidogenesis and aromatase activity in preeclampsia.
  • Nadia Berkane
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  • Guillaume Lefevre
  • Nadia Alfaidy
  • Roland Abi Nahed
  • Jessica Vincent
  • Jean-Paul Oudinet
  • Antoine Pianos
  • Annie Cambourg
  • Patrick Rozenberg
  • Pierre Galichon
  • Alexandra Rousseau
  • Tabassome Simon
  • Michael Schumacher
  • Nathalie Chabbert-Buffet
  • Alexandre Hertig
  • Placenta.2018 09;69:40-49. S0143-4004(18)30653-2. doi: 10.1016/j.placenta.2018.07.004.Epub 2018-07-07.

カナダ人患者の下痢便検体から分離されたClostridioides difficileの抗菌薬感受性：2013年から2017年までのCanadian Clostridioides difficile（CAN-DIFF）サーベイランス研究の結果の要約

Antimicrobial susceptibility of Clostridioides difficile isolated from diarrhoeal stool specimens of Canadian patients: summary of results from the Canadian Clostridioides difficile (CAN-DIFF) surveillance study from 2013 to 2017.
  • James A Karlowsky
  • Heather J Adam
  • Melanie R Baxter
  • Christopher W Dutka
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  • Nancy M Laing
  • George R Golding
  • George G Zhanel
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換気依存症の原因と診断、および離乳食の実施と請求に関する声明 - ドイツ呼吸器学会（DGP）と呼吸器科医会（VPK）が編纂

[Statement on Causes and Diagnostics of Ventilation Dependency as well as Implementation and Invoicing of the Weaning Process - Compiled by the German Respiratory Society (DGP) and the Association of Pneumological Clinics (VPK)].
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  • M Hetzel
  • M Pfeifer
  • Pneumologie.2019 12;73(12):716-722. doi: 10.1055/a-1039-7143.Epub 2019-12-09.

血漿プロテオミクスにより、重度の急性栄養不良を呈する HIV 感染児の代謝ストレスのマーカーが明らかになった

Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition.
  • Gerard Bryan Gonzales
  • James M Njunge
  • Bonface M Gichuki
  • Bijun Wen
  • Isabel Potani
  • Wieger Voskuijl
  • Robert H J Bandsma
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  • Sci Rep.2020 Jul;10(1):11235. 10.1038/s41598-020-68143-7. doi: 10.1038/s41598-020-68143-7.Epub 2020-07-08.

ステロイドホルモン受容体の変異体および変異体の転写活性の定量的評価 2 つのレポーターと受容体発現カセットを持つ単一ベクターを用いたステロイドホルモン受容体の変異体および変異体の転写活性の定量的評価

Quantitative Evaluation of the Transcriptional Activity of Steroid Hormone Receptor Mutants and Variants Using a Single Vector With Two Reporters and a Receptor Expression Cassette.
  • Huimin Ji
  • Ying Li
  • Zhao Liu
  • Min Tang
  • Lihui Zou
  • Fei Su
  • Yaqun Zhang
  • Junhua Zhang
  • Hexin Li
  • Lin Li
  • Bin Ai
  • Jie Ma
  • Lunan Wang
  • Ming Liu
  • Fei Xiao
  • Front Endocrinol (Lausanne).2020;11:167. doi: 10.3389/fendo.2020.00167.Epub 2020-03-31.

モルビリウイルスPeste des Petits Ruminantsの病原性単離株と変異株を区別するマウス細胞株の同定、病原性研究のための有望なツール

Identification of a murine cell line that distinguishes virulent from attenuated isolates of the morbillivirus Peste des Petits Ruminants, a promising tool for virulence studies.
  • Juliana Comerlato
  • Emmanuel Albina
  • Carinne Puech
  • Ana C Franco
  • Cécile Minet
  • Roger-Junior Eloiflin
  • Valérie Rodrigues
  • Renata Servan de Almeida
  • Virus Res..2020 May;286:198035. S0168-1702(20)30618-3. doi: 10.1016/j.virusres.2020.198035.Epub 2020-05-24.

黒色土壌へのバイオ炭の逐次施用による微生物応答と物理化学的特性に影響を与える新規環境因子の検討

Novel environmental factors affecting microbial responses and physicochemical properties by sequentially applied biochar in black soil.
  • Huanhuan Wang
  • Shen Yan
  • Tianbao Ren
  • Ye Yuan
  • Gang Kuang
  • Bo Wang
  • Fei Yun
  • Huilin Feng
  • Xiaoming Ji
  • Xiaojing Yuan
  • Guoshun Liu
  • Environ Sci Pollut Res Int.2020 Jul;10.1007/s11356-020-10081-y. doi: 10.1007/s11356-020-10081-y.Epub 2020-07-17.

IDOの阻害は、光線力学的治療と組み合わせることで、マウスのIL-6依存性全身炎症を引き起こす

Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy.
  • Malgorzata Wachowska
  • Joanna Stachura
  • Katarzyna Tonecka
  • Klaudyna Fidyt
  • Agata Braniewska
  • Zuzanna Sas
  • Iwona Kotula
  • Tomasz Piotr Rygiel
  • Louis Boon
  • Jakub Golab
  • Angelika Muchowicz
  • Cancer Immunol. Immunother..2020 Jun;69(6):1101-1112. 10.1007/s00262-020-02528-5. doi: 10.1007/s00262-020-02528-5.Epub 2020-02-28.

都市部で自然感染したLymnaea columella（軟体動物、ガストロプダ）由来のXiphidiocercariae：幼虫の形態学的・超構造と軟体動物宿主の組織学的変化

Xiphidiocercariae from naturally infected Lymnaea columella (Mollusca, Gastropoda) in urban area: morphology and ultrastructure of the larvae and histological changes in the mollusc host.
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イミノシュガーAMP-DNMはGLP1を介して満腹感を改善し、褐色脂肪組織を活性化する

The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1.
  • Daniela Herrera Moro Chao
  • Yanan Wang
  • Ewout Foppen
  • Roelof Ottenhoff
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  • Marco van Eijk
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  • Rolf Boot
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  • Mina Mirzaian
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  • Kirstin Jansen
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  • Diabetes.2019 12;68(12):2223-2234. db19-0049. doi: 10.2337/db19-0049.Epub 2019-10-02.

FDA承認の抗エストロゲン剤Faslodexを用いてERβ/アンジオポエチン-2/Tie-2シグナルを介した血管新生を標的とし、RCCにおけるスニチニブの感度を向上させる

Targeting the ERβ/Angiopoietin-2/Tie-2 signaling-mediated angiogenesis with the FDA-approved anti-estrogen Faslodex to increase the Sunitinib sensitivity in RCC.
  • Junfei Gu
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  • Bosen You
  • Chi-Ping Huang
  • Chawnshang Chang
  • Xiaolu Wang
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  • Cell Death Dis.2020 May;11(5):367. 10.1038/s41419-020-2486-0. doi: 10.1038/s41419-020-2486-0.Epub 2020-05-14.

ニコチンのピロリジニウム環のメチルスキャンにより、α7およびα4β2ニコチン性アセチルコリン受容体との相互作用に有意な差異が示された

A Methyl Scan of the Pyrrolidinium Ring of Nicotine Reveals Significant Differences in its Interactions with α7 and α4β2 Nicotinic Acetylcholine Receptors.
  • Hong Xing
  • Kristin W Andrud
  • Ferenc Soti
  • Anne Rouchaud
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  • Ziang Lu
  • Yeh-Hyon Cho
  • Sophia Habibi
  • Patrick Corsino
  • Svetoslav Slavov
  • James R Rocca
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  • Ron J Lukas
  • William Kem
  • Mol. Pharmacol..2020 May;mol.119.118786. doi: 10.1124/mol.119.118786.Epub 2020-05-30.

キク科Arctium lappa L. (Arctium lappa L.)のマンソニ桿菌および単純ヘルペスウイルス-1に対するin vitroの分裂毒殺および抗ウイルス活性

In vitro schistosomicidal and antiviral activities of Arctium lappa L. (Asteraceae) against Schistosoma mansoni and Herpes simplex virus-1.
  • Mirna Meana Dias
  • Ohana Zuza
  • Lorena R Riani
  • Priscila de Faria Pinto
  • Pedro Luiz Silva Pinto
  • Marcos P Silva
  • Josué de Moraes
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  • Fernanda de Oliveira Silva
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  • Biomed. Pharmacother..2017 Oct;94:489-498. S0753-3322(17)32153-4. doi: 10.1016/j.biopha.2017.07.116.Epub 2017-08-03.

ホルモン状態は、タモキシフェン治療を受けた乳癌患者におけるタモキシフェンとその主要代謝物の血漿中曝露に影響を与える

Hormonal status affects plasma exposure of tamoxifen and its main metabolites in tamoxifen-treated breast cancer patients.
  • João Paulo Bianchi Ximenez
  • Jurandyr Moreira de Andrade
  • Maria Paula Marques
  • Eduardo Barbosa Coelho
  • Guilherme Suarez-Kurtz
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敗血症性ショック患者におけるトリプトファン経路の異化産物（セロトニン、5-ヒドロキシインドラ酢酸、キヌレニン）および酵素（モノアミンオキシダーゼおよびインドールアミン2,3ジオキシゲナーゼ）：前向き観察研究対健常対照

Tryptophan pathway catabolites (serotonin, 5-hydroxyindolacetic acid, kynurenine) and enzymes (monoamine oxidase and indole amine 2,3 dioxygenase) in patients with septic shock: A prospective observational study versus healthy controls.
  • Gilles Troché
  • Matthieu Henry-Lagarrigue
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  • Odile Spreux-Varoquaux
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劣化ウランと湾岸戦争による疾病劣化ウランと湾岸戦争症候群の背後にある可能性のあるメカニズムについての最新情報とコメントを掲載しています

Depleted uranium and Gulf War Illness: Updates and comments on possible mechanisms behind the syndrome.
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  • Lyudmila Pivina
  • Maryam Dadar
  • Yuliya Semenova
  • Md Mostafizur Rahman
  • Salvatore Chirumbolo
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運動とキヌレニン経路。現在の知見と、持久力トレーニングとレジスタンストレーニングの急性効果を比較した無作為化クロスオーバー試験の結果

Exercise and the Kynurenine pathway: Current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and resistance training.
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  • Felix Kummerhoff
  • Christina Koliamitra
  • Alexander Schenk
  • David Walzik
  • Luca Hardt
  • Andre Knoop
  • Mario Thevis
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  • Wilhelm Bloch
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中国人乳癌患者におけるタモキシフェン関連内分泌症状。試験プロトコール臨床試験（SPIRIT準拠）

Tamoxifen-related endocrine symptoms in Chinese patients with breast cancer: Study protocol clinical trial (SPIRIT Compliant).
  • Carmen Wing Han Chan
  • Christine Miaskowski
  • Alexandra McCarthy
  • Mary Miu Yee Waye
  • Winnie Yeo
  • Winnie Kwok Wai So
  • Kai Chow Choi
  • Stephen Kwok Wing Tsui
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サルコイドーシスにおける関節、筋肉、骨の有病率、分布、臨床的意義：F-FDG-PET/CT試験

Prevalence, distribution and clinical significance of joints, muscles and bones in sarcoidosis: an F-FDG-PET/CT study.
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  • Lykourgos Kolilekas
  • Nikoletta K Pianou
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  • Anastasia Papaporfyriou
  • Maria Kallieri
  • Vasiliki Apollonatou
  • Georgia Papadaki
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クルクミンは相乗的にラットの慢性デルタメトリン腎毒性に対するシタグリプチンの保護効果を増強する。プロ炎症性サイトカインとNrf2/HO-1経路への影響

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro-inflammatory cytokines and Nrf2/Ho-1 pathway.
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死後CTの導入は日常診療において従来の剖検率に悪影響を与えることなく死後検診率を向上させる：実施研究

Introduction of postmortem CT increases the postmortem examination rate without negatively impacting the rate of traditional autopsy in daily practice: an implementation study.
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湾岸戦争病、ポストＨＰＶワクチン接種症候群、およびマクロファージ性筋膜炎。ワクチン誘発性自己免疫性自律神経失調症と関連している可能性のある同様の障害状態

Gulf war illness, post-HPV vaccination syndrome, and Macrophagic Myofasciitis. Similar disabling conditions possibly linked to vaccine-induced autoimmune dysautonomia.
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  • Melina Tejada-Ruiz
  • Autoimmun Rev.2020 Jul;:102603. S1568-9972(20)30167-1. doi: 10.1016/j.autrev.2020.102603.Epub 2020-07-10.

積極的なサーベイランスが検討されている、またはすでに行われている患者における前立腺のマルチパラメトリックMRIの利用。画像ガイド下の標的生検との相関

Utilization of Multiparametric MRI of Prostate in Patients under Consideration for or Already in Active Surveillance: Correlation with Imaging Guided Target Biopsy.
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  • Ann S Fulcher
  • Sarah Winks
  • Mary A Turner
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camptodactyly-arthropathy-coxa vara-pericarditis (CACP)症候群の無関係11家族35例の遺伝子型-フェノタイプ調査

Genotype-phenotype investigation of 35 patients from 11 unrelated families with camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome.
  • Saliha Yilmaz
  • Dilek Uludağ Alkaya
  • Özgür Kasapçopur
  • Kenan Barut
  • Ekin S Akdemir
  • Cemre Celen
  • Mark W Youngblood
  • Katsuhito Yasuno
  • Kaya Bilguvar
  • Murat Günel
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後側脛骨プラトー骨折に対する修正された前側方アプローチによる低侵襲リムプレート骨合成を関節鏡下で補助し、3次元的にモデル化した

Arthroscopically assisted and three-dimensionally modeled minimally invasive rim plate osteosynthesis via modified anterolateral approach for posterolateral tibial plateau fractures.
  • Marco Delcogliano
  • Roberto Marin
  • Luca Deabate
  • Davide Previtali
  • Giuseppe Filardo
  • Michele Francesco Surace
  • Christian Candrian
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  • Knee.2020 Jun;27(3):1093-1100. S0968-0160(20)30049-1. doi: 10.1016/j.knee.2020.02.011.Epub 2020-04-01.

マディヤ・プラデシュ州の施設出産を促進するための州主導の「Janani Sahayogi Yojana」官民パートナーシッププログラムへの参加：民間産科医パートナーからの見解

Participation in the state led 'Janani Sahayogi Yojana' public private partnership program to promote facility births in Madhya Pradesh, India: views from private obstetrician partners.
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  • Kate Jehan
  • Ayesha De Costa
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コロナウイルス疾患における胸部CT所見の標準化診断基準の使用の初期結果 2019

Initial Results of the Use of a Standardized Diagnostic Criteria for Chest Computed Tomography Findings in Coronavirus Disease 2019.
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  • Ana Paula Alves Fonseca
  • Eduardo Pinheiro Zarattini Anastacio
  • Fernanda Formagio Minenelli
  • Conrado Furtado de Albuquerque Cavalcanti
  • Gustavo Borges da Silva Teles
  • J Comput Assist Tomogr.2020 Jul;doi: 10.1097/RCT.0000000000001054.Epub 2020-07-07.

FcRnは、FcγRsではなく、FcRnがヒトIgG抗体の母体-胎児トランスプラセン輸送を駆動する

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies.
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  • Stylianos Bournazos
  • Natalie K Thulin
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ショウジョウバエのFUSとAubが神経障害におけるpiRNAの生合成に果たす新たな役割

Novel roles of Drosophila FUS and Aub responsible for piRNA biogenesis in neuronal disorders.
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  • Ryo Tanaka
  • Tomoki Hirashima
  • Yuuka Muraoka
  • Yumiko Azuma
  • Hideki Yoshida
  • Takahiko Tokuda
  • Satoshi Asada
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4つのリソソーム貯蔵疾患におけるストップコドンリードスルー治療のためのアミノグリコシドおよび非アミノグリコシド化合物の評価

Evaluation of Aminoglycoside and Non-Aminoglycoside Compounds for Stop-Codon Readthrough Therapy in Four Lysosomal Storage Diseases.
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  • Elena Garrido
  • Mónica Cozar
  • Víctor Rodriguez-Sureda
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  • Concepción Arenas
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Atriplex inflataのMolluscicidal and LARVICIDAL ACTIVITIES OF AERIAL PARTS INTO THE MOLLUSK Galba truncatula, INTERMEDIATE HOST OF Fasciola hepatica

MOLLUSCICIDAL AND LARVICIDAL ACTIVITIES OF Atriplex inflata AERIAL PARTS AGAINST THE MOLLUSK Galba truncatula, INTERMEDIATE HOST OF Fasciola hepatica.
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  • Mohamed Damak
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非小細胞肺癌患者におけるマウスダブルミニッツ2ホモログとP73の発現は成長停止DNA損傷誘導遺伝子45αとは相関がなかった：STROBE準拠の研究

The expression of mouse double minute 2 homolog and P73 had no correlation with growth arrest DNA damage-inducible gene 45α in patients with non-small-cell lung carcinoma: A STROBE-compliant study.
  • Bo Wang
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  • Huifeng Liu
  • Jixing Lin
  • Bailin Wang
  • Kaijie Fan
  • Zhipeng Ren
  • Bin Wang
  • Tong Li
  • Kang Qi
  • Xiaodong Tian
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転写ダイナミクスがポリ(A)テールとRNA分解機械の発現を制御してmRNAレベルをバランスさせる

Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels.
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  • Anat Bahat
  • Urmila Sehrawat
  • Shirly Becker-Herman
  • Binyamin Zuckerman
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  • Reuven Agami
  • Igor Ulitsky
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  • Rivka Dikstein
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血液学的悪性腫瘍（アダマンチン）患者における復職のための医療社会的要因の分析：「パイロット研究」の結果

Analysis of medico-social factors for return to work among patients presenting with haematological malignancy (adamantine): results of a 'pilot study'.
  • Bénédicte Clin
  • Natacha Heutte
  • Mathilde Boulanger
  • Xavier Troussard
  • Edouard Cornet
  • Ghandi Laurent Damaj
  • Véronique Bouvier
  • Anne-Valérie Guizard
  • Guy Launoy
  • Idlir Licaj
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RNA-seqトランスクリプトーム解析により、リポ多糖類（LPS）注射後のヒト末梢血単核細胞（PBMCs）におけるLTR-レトロトランスポゾンの変調が明らかになった

RNA-seq transcriptome analysis reveals LTR-retrotransposons modulation in Human Peripheral Blood Mononuclear Cells (PBMCs) after Lipopolysaccharides (LPS) injection.
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  • Olivier Tabone
  • Maxime Bodinier
  • Nicole Grandi
  • Julien Textoris
  • François Mallet
  • Enzo Tramontano
  • J. Virol..2020 Jul;JVI.00587-20. doi: 10.1128/JVI.00587-20.Epub 2020-07-15.

RIFM香料成分安全性評価、3-(4-メチル-3-ペンテニル)-3-シクロヘキセン-1-カルボニトリル、CAS登録番号68084-04-8

RIFM fragrance ingredient safety assessment, 3-(4-methyl-3-pentenyl)-3-cyclohexene-1-carbonitrile, CAS registry number 68084-04-8.
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拡大する生殖細胞ABL1関連先天性心欠損・骨格奇形症候群の臨床表現型

The expanding clinical phenotype of germline ABL1-associated congenital heart defects and skeletal malformations syndrome.
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  • Emeline Crutcher
  • Harinder Gill
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  • Rolph Pfundt
  • Chitra Prasad
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  • Madeleine Fannemel
  • Eirik Frengen
  • Doriana Misceo
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  • Yaping Yang
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ステージIおよびIIのトリプルネガティブ乳癌に対するネオアジュバント化学療法の回避と期間短縮：Ki-67標識指数とアポクリン型病変の認識の重要性

Avoidance and Period-Shortening of Neoadjuvant Chemotherapy Against Triple-Negative Breast Cancer in Stages I and II: Importance of Ki-67 Labeling Index and the Recognition of Apocrine-Type Lesions.
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  • Kyosuke Shimada
  • Takamichi Yokoe
  • Yutaka Tsutsumi
  • Technol. Cancer Res. Treat..2020 Jan-Dec;19:1533033820943246. doi: 10.1177/1533033820943246.

心肺バイパス回路内の大量空気除去のための3つの方法の評価：西中国病院でのシミュレーションベースの多分野トレーニング

Assessment of three methods for removing massive air in a cardiopulmonary bypass circuit: simulation-based multi-discipline training in West China Hospital.
  • Ting Liu
  • Zhen Qin
  • Ming Luo
  • Zhao-Xia Tan
  • Ji-Yue Xiong
  • Gang-Jian Gu
  • Xiang Yu
  • Qi Li
  • Rong-Hua Zhou
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背側腰椎椎体間癒合術後の脊柱腰椎パラメータの回復におけるローディオティックケージの影響：レトロスペクティブな症例対照研究

Impact of lordotic cages in the restoration of spinopelvic parameters after dorsal lumbar interbody fusion: a retrospective case control study.
  • Stavros Oikonomidis
  • Vincent Heck
  • Sonja Bantle
  • Max Joseph Scheyerer
  • Christoph Hofstetter
  • Stefan Budde
  • Peer Eysel
  • Jan Bredow
  • Int Orthop.2020 Jul;10.1007/s00264-020-04719-2. doi: 10.1007/s00264-020-04719-2.Epub 2020-07-13.

WMA：メタアナリシスを実行するためのウィザードシステムアーキテクチャ。アジア大豆さび病の防除におけるフルキンコナゾールの有効性を検証するために適用したケーススタディ

WMA: Wizard System Architecture for the execution of meta-analysis: A case study applied to verify the efficacy of fluquinconazole in the control of Asian soybean rust.
  • Bruna R Delazeri
  • Suelyn F DA Silva
  • Simone N Matos
  • Alaine M Guimarães
  • Marcelo G Canteri
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乳房切除術または美容乳房手術後のインプラント破裂が疑われる症例における外科医選択の決定因子。臨床的意義

Determinants of surgeon choice in cases of suspected implant rupture following mastectomy or aesthetic breast surgery: Clinical implications.
  • Nicola Zingaretti
  • Emanuele Rampino Cordaro
  • Pier Camillo Parodi
  • Giulia Marega
  • Francesca Modolo
  • Carlo Moreschi
  • Ugo Da Broi
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裸のモグララットは、非機能的なペプチド性疼痛経路を持っているにもかかわらず、機能的なプリンリン作動性疼痛経路を持っている

The naked mole-rat has a functional purinergic pain pathway despite having a non-functional peptidergic pain pathway.
  • Brigitte M Browe
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  • Cesar Ramirez
  • Rebecca H Rickman
  • Ewan St John Smith
  • Thomas J Park
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報告書。アルコールとニコチン使用障害の両方を持つ個人におけるコチニンレベルとオキシトシン、β-エンドルフィン、およびオレキシンの末梢性内因性濃度との関係

Brief Report: Relationship Between Cotinine Levels and Peripheral Endogenous Concentrations of Oxytocin, β-Endorphin, and Orexin in Individuals With Both Alcohol and Nicotine Use Disorders.
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  • Roberta Perciballi
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  • Mary R Lee
  • William H Zywiak
  • Jonathan Kurtis
  • Robert M Swift
  • Lorenzo Leggio
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南アフリカのケープタウンの若い女性の間で経口PrEPの需要を創出するための行動中心設計戦略の評価

Evaluation of a behavior-centered design strategy for creating demand for oral PrEP among young women in Cape Town, South Africa.
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  • Laura Myers
  • Katherine Gill
  • Linda-Gail Bekker
  • Gabrielle Stein
  • Katherine K Thomas
  • Menna Duyver
  • Ariane van der Straten
  • Margaret McConnell
  • Robert Aunger
  • Valerie Curtis
  • Jessie de Witt Huberts
  • Lut Van Damme
  • Jared M Baeten
  • Connie Celum
  • Gates Open Res.2020;4:29. doi: 10.12688/gatesopenres.13103.2.Epub 2020-07-03.

貧血と血液希釈：赤血球質量測定2858回に基づく単一センターコホートの解析

Anemia and hemodilution: analysis of a single center cohort based on 2858 Red Cell Mass measurements.
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  • Nabih Maslah
  • Juliette Soret-Dulphy
  • Christine Dosquet
  • Odno Ravdan
  • Laetitia Vercellino
  • Célia Belkhodja
  • Nathalie Parquet
  • Anne C Brignier
  • Marie-Hélène Schlageter
  • Bruno Cassinat
  • Jean-Jacques Kiladjian
  • Christine Chomienne
  • Stéphane Giraudier
  • Haematologica.2020 Jun;haematol.2020.249409. doi: 10.3324/haematol.2020.249409.Epub 2020-06-25.

CD4+/CD8+比は不安定狭心症患者の冠動脈プラーク不安定性と正の相関があるが、主要な心血管系イベントの予測には至らなかった

CD4+/CD8+ ratio positively correlates with coronary plaque instability in unstable angina pectoris patients but fails to predict major adverse cardiovascular events.
  • Dayang Chai
  • Xiangquan Kong
  • Shu Lu
  • Junjie Zhang
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NSsのアミロイド形成は、マウスのリフトバレー熱ウイルスの病原性と関連している

NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice.
  • Psylvia Léger
  • Eliana Nachman
  • Karsten Richter
  • Carole Tamietti
  • Jana Koch
  • Robin Burk
  • Susann Kummer
  • Qilin Xin
  • Megan Stanifer
  • Michèle Bouloy
  • Steeve Boulant
  • Hans-Georg Kräusslich
  • Xavier Montagutelli
  • Marie Flamand
  • Carmen Nussbaum-Krammer
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スケーリングおよび根面プレーニングの補助としての光力学的治療とアレンドロネートナトリウム外用剤の併用の有無。ラットを用いた組織化学的および免疫組織化学的試験

Topical sodium alendronate combined or not with photodynamic therapy as an adjunct to scaling and root planing: Histochemical and immunohistochemical study in rats.
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大動脈弁狭窄症におけるMMP-10（マトリックスメタロプロテアーゼ-10）の役割

A Role for MMP-10 (Matrix Metalloproteinase-10) in Calcific Aortic Valve Stenosis.
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  • Amaya Fernández-Celis
  • Adela Navarro
  • Virginia Álvarez
  • Alicia Gainza
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  • Arterioscler. Thromb. Vasc. Biol..2020 05;40(5):1370-1382. doi: 10.1161/ATVBAHA.120.314143.Epub 2020-03-19.

microRNA-342による抗アポトーシス遺伝子BCL2L1、MCL1の発現抑制と神経膠芽腫細胞のアポトーシス誘導に関する研究

Inhibiting the expression of anti-apoptotic genes BCL2L1 and MCL1, and apoptosis induction in glioblastoma cells by microRNA-342.
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  • Rezvan Rezazadeh Valojerdi
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  • Biomed. Pharmacother..2020 Jan;121:109641. S0753-3322(19)35263-1. doi: 10.1016/j.biopha.2019.109641.Epub 2019-11-18.

宿主由来のバイオマーカーと患者特性を組み合わせることで、結核治療成績の予測におけるシグネチャの性能が向上する

Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes.
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  • Synne Jenum
  • Mario Vaz
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皮膚常在菌に対する免疫は乾癬状皮膚の炎症を促進する

Immunity to commensal skin fungi promotes psoriasiform skin inflammation.
  • Charlotte Hurabielle
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  • Nicolas Bouladoux
  • Seong-Ji Han
  • Eric Dean Merrill
  • Yaima L Lightfoot
  • Nickie Seto
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  • Proc. Natl. Acad. Sci. U.S.A..2020 Jul;117(28):16465-16474. 2003022117. doi: 10.1073/pnas.2003022117.Epub 2020-06-29.

カリブ海地域におけるADHDリスクを支える遺伝的変異

Genetic Variation Underpinning ADHD Risk in a Caribbean Community.
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  • Martha L Cervantes-Henríquez
  • Martha L Martínez-Banfi
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  • Manuel Sánchez-Rojas
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  • Antonio Acosta-Hoyos
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  • Claudio A Mastronardi
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  • Mauricio Arcos-Burgos
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  • Cells.2019 08;8(8). E907. doi: 10.3390/cells8080907.Epub 2019-08-16.

膵頭十二指腸摘術後の膵瘻グレードCの危険因子：大規模前向き多施設日台共同研究

Risk factors for pancreatic fistula grade C after pancreatoduodenectomy: a large prospective, multicenter Japan-Taiwan collaboration study.
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  • Toshio Shimokawa
  • Yuichi Nagakawa
  • Yi-Ming Shyr
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  • Sohei Satoi
  • Hideyuki Yoshitomi
  • Takehiro Okabayashi
  • Fuyuhiko Motoi
  • Ryosuke Amano
  • Yoshiaki Murakami
  • Satoshi Hirano
  • Kazuyuki Kawamoto
  • Shoji Nakamori
  • Yan-Shen Shan
  • Shinjiro Kobayashi
  • Hiroyuki Nitta
  • Hiroyoshi Matsukawa
  • Kazuhisa Uchiyama
  • Chih-Po Hsu
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光線治療を受けた期の新生児における重度の高ビリルビン血症に関連する危険因子としての遺伝的因子および遅延したTSBモニタリングと治療

Genetic Factors and Delayed TSB Monitoring and Treatment as Risk Factors Associated with Severe Hyperbilirubinemia in Term Neonates Admitted for Phototherapy.
  • Nem-Yun Boo
  • Shwe Sin
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  • J. Trop. Pediatr..2020 Jun;fmaa016. doi: 10.1093/tropej/fmaa016.Epub 2020-06-24.

ホットメルトエクストルージョンは、経皮吸収型製剤のためのシクロデキストリンベースのポリ(擬似)ロタキサンの特性を改善する

Hot melt-extrusion improves the properties of cyclodextrin-based poly(pseudo)rotaxanes for transdermal formulation.
  • Ricardo N Marreto
  • Gleidson Cardoso
  • Bruno Dos Santos Souza
  • Manuel Martin-Pastor
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  • Int J Pharm.2020 Jun;586:119510. S0378-5173(20)30494-4. doi: 10.1016/j.ijpharm.2020.119510.Epub 2020-06-09.

慢性喫煙における網膜色素上皮のトランスクリプトーム解析から、自然免疫応答の抑制と分化経路の活性化が明らかになった

Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways.
  • Lei Wang
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  • Matthew J Brooks
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  • Free Radic. Biol. Med..2020 Jul;156:176-189. S0891-5849(20)31092-3. doi: 10.1016/j.freeradbiomed.2020.06.004.Epub 2020-07-04.

クロザピン初回入院時のクロザピン滴定中に急性低体温症を発症した症例報告と、クロザピン誘発性体温調節障害に関する現在の文献のレビュー

A case report of acute hypothermia during initial inpatient clozapine titration with review of current literature on clozapine-induced temperature dysregulations.
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  • BMC Psychiatry.2020 Jun;20(1):290. 10.1186/s12888-020-02695-w. doi: 10.1186/s12888-020-02695-w.Epub 2020-06-09.

リジンアセチルトランスフェラーゼTip60は造血幹細胞の維持に必要である

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.
  • Akihiko Numata
  • Hui Si Kwok
  • Qi-Ling Zhou
  • Jia Li
  • Roberto Tirado-Magallanes
  • Vladimir Espinosa Angarcia
  • Rebecca Louise Hannah
  • Jihye Park
  • Chelsia Qiuxia Wang
  • Vaidehi Krishnan
  • Deepa Rajagopalan
  • Yangzhou Zhang
  • Siqin Zhou
  • Robert Welner
  • Motomi Osato
  • Sudhakar Jha
  • Stefan K Bohlander
  • Bertie Göttgens
  • Henry Yang
  • Touati Benoukraf
  • John W Lough
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  • Blood.2020 Jun;blood.2019001279. doi: 10.1182/blood.2019001279.Epub 2020-06-15.

ユーイング肉腫に対するIGF-1R/mTOR標的治療。プロテオミクスおよび放射線学的予測バイオマーカーにマッチした5つのIGF-1R関連試験のメタアナリシス

IGF-1R/mTOR Targeted Therapy for Ewing Sarcoma: A Meta-Analysis of Five IGF-1R-Related Trials Matched to Proteomic and Radiologic Predictive Biomarkers.
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  • Vivek Subbiah
  • Brian A Menegaz
  • Deeksha Vishwamitra
  • Ghazaleh Eskandari
  • Bhawana George
  • Robert S Benjamin
  • Shreyaskumar Patel
  • Juhee Song
  • Alexander J Lazar
  • Wei-Lien Wang
  • Razelle Kurzrock
  • Alberto Pappo
  • Peter M Anderson
  • Gary K Schwartz
  • Dejka Araujo
  • Branko Cuglievan
  • Ravin Ratan
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  • Joseph A Ludwig
  • Cancers (Basel).2020 Jul;12(7). E1768. doi: 10.3390/cancers12071768.Epub 2020-07-02.

大動脈プラーク分布、大動脈プラークと動脈硬化性リスク因子との関連。大動脈血管造影検査を用いた研究

Aortic Plaque Distribution, and Association between Aortic Plaque and Atherosclerotic Risk Factors: An Aortic Angioscopy Study.
  • Keisuke Kojima
  • Shigeki Kimura
  • Kazuto Hayasaka
  • Masafumi Mizusawa
  • Toru Misawa
  • Yosuke Yamakami
  • Yuichiro Sagawa
  • Hirofumi Ohtani
  • Keiichi Hishikari
  • Tomoyo Sugiyama
  • Hiroyuki Hikita
  • Atsushi Takahashi
  • J. Atheroscler. Thromb..2019 Nov;26(11):997-1006. doi: 10.5551/jat.48181.Epub 2019-03-27.

歯周炎における特殊なプロ分解脂質メディエーターと対応するレセプター遺伝子の発現の特徴的なプロファイル

Distinct Profiles of Specialized Pro-resolving Lipid Mediators and Corresponding Receptor Gene Expression in Periodontal Inflammation.
  • Brittney Ferguson
  • Nishantha R Bokka
  • Krishna Rao Maddipati
  • Srinivas Ayilavarapu
  • Robin Weltman
  • Lisha Zhu
  • Wanqi Chen
  • W Jim Zheng
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  • Thomas E Van Dyke
  • Chun-Teh Lee
  • Front Immunol.2020;11:1307. doi: 10.3389/fimmu.2020.01307.Epub 2020-06-25.

低酸素血症患者の脳死判定における無呼吸テストの代替としてのCPAPの使用。2つのケースの報告

Use of CPAP as an alternative to the apnea test during the determination of brain death in hypoxemic patients. Report of two cases.
  • Glauco Adrieno Westphal
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  • Verônica Westphal
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  • Luciano Rodrigues da Silva
  • Jorge Luis Dos Santos Valiatti
  • Rev Bras Ter Intensiva.2020 Jun;S0103-507X2020005002204. doi: 10.5935/0103-507X.20200032.Epub 2020-06-24.

泌尿器系がんの治療を延期することによるリスク。COVID-19パンデミック時のトリアージと管理を支援するための共同レビュー

Risks from Deferring Treatment for Genitourinary Cancers: A Collaborative Review to Aid Triage and Management During the COVID-19 Pandemic.
  • Christopher J D Wallis
  • Giacomo Novara
  • Laura Marandino
  • Axel Bex
  • Ashish M Kamat
  • R Jeffrey Karnes
  • Todd M Morgan
  • Nicolas Mottet
  • Silke Gillessen
  • Alberto Bossi
  • Morgan Roupret
  • Thomas Powles
  • Andrea Necchi
  • James W F Catto
  • Zachary Klaassen
  • Eur. Urol..2020 Jul;78(1):29-42. S0302-2838(20)30331-6. doi: 10.1016/j.eururo.2020.04.063.Epub 2020-05-03.

内視鏡的超音波ガイド下choledochododenodenostomyに続いて行われた膵頭十二指腸切除術と電気焼灼術で強化された内腔吸引ステントのACHBT-SFED試験

Pancreaticoduodenectomy following endoscopic ultrasound-guided choledochoduodenostomy with electrocautery-enhanced lumen-apposing stents an ACHBT - SFED study.
  • Sébastien Gaujoux
  • Jérémie Jacques
  • Raphael Bourdariat
  • Laurent Sulpice
  • Mickael Lesurtel
  • Stéphanie Truant
  • Fabien Robin
  • Frédéric Prat
  • Maxime Palazzo
  • Lilian Schwarz
  • Emmanuel Buc
  • Alain Sauvanet
  • Abdelkader Taibi
  • Bertrand Napoleon
  • HPB (Oxford).2020 Jul;S1365-182X(20)31048-0. doi: 10.1016/j.hpb.2020.06.001.Epub 2020-07-06.

アフリカ系米国人における長期的な心血管系および腎疾患転帰の予測因子としての24時間血圧と診療所血圧の比較

Twenty-four-hour versus clinic blood pressure levels as predictors of long-term cardiovascular and renal disease outcomes among African Americans.
  • Srividya Kidambi
  • Tao Wang
  • Thomas Chelius
  • Irene Nunuk
  • Priyanka Agarwal
  • Purushottam Laud
  • David Mattson
  • Allen W Cowley
  • Mingyu Liang
  • Theodore Kotchen
  • Sci Rep.2020 Jul;10(1):11685. 10.1038/s41598-020-68466-5. doi: 10.1038/s41598-020-68466-5.Epub 2020-07-15.

国際的な前向きコホート研究のデータに基づいた胎児の妊娠年齢の正確な推定と胎児の成長の個人化された予測の達成：人口ベースの機械学習研究

Achieving accurate estimates of fetal gestational age and personalised predictions of fetal growth based on data from an international prospective cohort study: a population-based machine learning study.
  • Russell Fung
  • Jose Villar
  • Ali Dashti
  • Leila Cheikh Ismail
  • Eleonora Staines-Urias
  • Eric O Ohuma
  • Laurent J Salomon
  • Cesar G Victora
  • Fernando C Barros
  • Ann Lambert
  • Maria Carvalho
  • Yasmin A Jaffer
  • J Alison Noble
  • Michael G Gravett
  • Manorama Purwar
  • Ruyan Pang
  • Enrico Bertino
  • Shama Munim
  • Aung Myat Min
  • Rose McGready
  • Shane A Norris
  • Zulfiqar A Bhutta
  • Stephen H Kennedy
  • Aris T Papageorghiou
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  • Lancet Digit Health.2020 Jul;2(7):e368-e375. S2589-7500(20)30131-X. doi: 10.1016/S2589-7500(20)30131-X.Epub 2020-06-23.

マンノース標識ポリ(d, l-ラクチド-コ-グリコリド)ナノ粒子を用いたがん免疫療法のための樹状細胞への選択的腫瘍特異的抗原送達の研究

Selective Tumor-Specific Antigen Delivery to Dendritic Cells Using Mannose-Labeled Poly(d, l-lactide-co-glycolide) Nanoparticles for Cancer Immunotherapy.
  • Tae In Wi
  • Yeongseon Byeon
  • Ji Eun Won
  • Jae Myeong Lee
  • Tae Heung Kang
  • Jeong-Won Lee
  • Young Joo Lee
  • Anil K Sood
  • Hee Dong Han
  • Yeong-Min Park
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運動誘発性筋損傷の兆候や症状を軽減し、アスリートの回復を促進するための栄養介入：現在の知見、実用化、将来の展望

Nutritional interventions for reducing the signs and symptoms of exercise-induced muscle damage and accelerate recovery in athletes: current knowledge, practical application and future perspectives.
  • Tindaro Bongiovanni
  • Federico Genovesi
  • Monika Nemmer
  • Christopher Carling
  • Giampietro Alberti
  • Glyn Howatson
  • Eur. J. Appl. Physiol..2020 Jul;10.1007/s00421-020-04432-3. doi: 10.1007/s00421-020-04432-3.Epub 2020-07-13.

非悪性中心気道閉塞に対する治療的気管支鏡介入は、症状と機能状態の迅速かつ持続的な改善をもたらす

Therapeutic bronchoscopic interventions for nonmalignant central airway obstruction provide rapid and sustained improvement in symptoms and functional status.
  • Prajowl Shrestha
  • Karan Madan
  • Vijay Hadda
  • Ashish Upadhyay
  • Saurabh Mittal
  • Pawan Tiwari
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  • Randeep Guleria
  • Anant Mohan
  • Lung India.2020 Jul-Aug;37(4):295-299. LungIndia_2020_37_4_295_288747. doi: 10.4103/lungindia.lungindia_476_19.

LGR5/β-カテニン/miR-142-3pネットワークを介した薬剤耐性結腸がんの治療とがん関連線維芽細胞形質転換の抑制を目的とした新規低分子MSI-N1014の前臨床評価

Preclinical Evaluation of the Novel Small-Molecule MSI-N1014 for Treating Drug-Resistant Colon Cancer via the LGR5/β-catenin/miR-142-3p Network and Reducing Cancer-Associated Fibroblast Transformation.
  • Vijesh Kumar Yadav
  • Yan-Jiun Huang
  • Thomashire Anita George
  • Po-Li Wei
  • Maryam Rachmawati Sumitra
  • Ching-Liang Ho
  • Tzu-Hao Chang
  • Alexander T H Wu
  • Hsu-Shan Huang
  • Cancers (Basel).2020 Jun;12(6). E1590. doi: 10.3390/cancers12061590.Epub 2020-06-16.

レトロゾールとメトロニダゾールの構造研究とグラフェンとフラーレンを用いた自己集合体の形成と物理的、化学的、生物学的活性の向上

Structural study of letrozole and metronidazole and formation of self-assembly with graphene and fullerene with the enhancement of physical, chemical and biological activities.
  • Aljawhara H Almuqrin
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  • Y Shyma Mary
  • Renjith Thomas
  • J. Biomol. Struct. Dyn..2020 Jul;:1-7. doi: 10.1080/07391102.2020.1790420.Epub 2020-07-13.

グルココルチコイド受容体のリン酸化を介したシナプス可塑性が、グルタミン酸一ナトリウムによって誘導される不安誘発性・抑うつ性行動に果たす役割

Role of glucocorticoid receptor phosphorylation-mediated synaptic plasticity in anxiogenic and depressive behaviors induced by monosodium glutamate.
  • Wen Zhu
  • Feng Yang
  • Xiaofang Cai
  • Wen Zhang
  • Jingsi Zhang
  • Min Cai
  • Xiangting Li
  • Jun Xiang
  • Dingfang Cai
  • Naunyn Schmiedebergs Arch. Pharmacol..2020 May;10.1007/s00210-020-01845-x. doi: 10.1007/s00210-020-01845-x.Epub 2020-05-22.

オピオイド受容体からのネオクレロダンジテルペンの合成研究オピオイド受容体におけるGタンパク質活性化バイアスと活性を向上させた類似体の設計・合成・評価

Synthetic Studies of Neoclerodane Diterpenes from : Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ-Opioid Receptor.
  • Rachel S Crowley
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  • Richard J Anderson
  • Dan Luo
  • Sophia Kaska
  • Pamela Maynez
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  • ACS Chem Neurosci.2020 Jun;11(12):1781-1790. doi: 10.1021/acschemneuro.0c00191.Epub 2020-05-26.

No Pouch, no problem: Zenker's diverticulumに対する修正された口腔周囲内視鏡下筋切開術を用いた症状のある上咽頭バーの内視鏡的分割術の成功

No pouch, no problem: successful endoscopic division of a symptomatic cricopharyngeal bar using a modified peroral endoscopic myotomy technique for Zenker's diverticulum.
  • Sarah S Al Ghamdi
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  • Thomas M Runge
  • Yervant Ichkhanian
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  • VideoGIE.2020 Jul;5(7):281-282. S2468-4481(20)30078-3. doi: 10.1016/j.vgie.2020.03.006.Epub 2020-05-07.

エチオピア北部アディグラート総合病院の高活性レトロウイルス療法を受けているHIV患者におけるウイルス学的障害の増加とその決定要因、2019年：病院ベースの横断的研究

Increased Virological Failure and Determinants Among HIV Patients on Highly Active Retroviral Therapy in Adigrat General Hospital, Northern Ethiopia, 2019: Hospital-Based Cross-Sectional Study.
  • Hadush Negash
  • Miglas Welay
  • Haftom Legese
  • Gebre Adhanom
  • Fitsum Mardu
  • Kebede Tesfay
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  • Infect Drug Resist.2020;13:1863-1872. 251619. doi: 10.2147/IDR.S251619.Epub 2020-06-18.

マルチモーダル鎮痛レジームの一環としての周術期のデュロキセチン投与は腰部管狭窄症手術の術後疼痛を軽減する：無作為化、三重盲検、プラセボ対照試験

Perioperative duloxetine as part of a multimodal analgesia regime reduces postoperative pain in lumbar canal stenosis surgery: a randomized, triple blind, and placebo-controlled trial.
  • Nishith Govil
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  • Pankaj Arora
  • Hariom Khandelwal
  • Ashutosh Singh
  • Korean J Pain.2020 Jan;33(1):40-47. kjp.2020.33.1.40. doi: 10.3344/kjp.2020.33.1.40.

マウスのLPS誘発性間質性膀胱炎における植物由来および合成カンナビノイドリガンドによるカンナビノイド2受容体の活性化実験

Experimental Cannabinoid 2 Receptor Activation by Phyto-Derived and Synthetic Cannabinoid Ligands in LPS-Induced Interstitial Cystitis in Mice.
  • Geraint Berger
  • Nipun Arora
  • Ian Burkovskiy
  • Yanfang Xia
  • Anu Chinnadurai
  • Robert Westhofen
  • Georg Hagn
  • Ashley Cox
  • Melanie Kelly
  • Juan Zhou
  • Christian Lehmann
  • Molecules.2019 Nov;24(23). E4239. doi: 10.3390/molecules24234239.Epub 2019-11-21.

救急科を基盤とした精神保健リエゾンナースサービスの評価。マルチサイトトランスレーショナルリサーチプロジェクト

Evaluating an emergency department-based mental health liaison nurse service: A multi-site translational research project.
  • Timothy Wand
  • Gemma Collett
  • Alexa Cutten
  • Amanda Stack
  • Michael Dinh
  • Kendal Bein
  • Timothy Green
  • Saartje Berendsen-Russell
  • James Edwards
  • Kathryn White
  • Emerg Med Australas.2020 Jul;doi: 10.1111/1742-6723.13583.Epub 2020-07-18.

噛んだ白樺ピッチから得られた5700年前のヒトゲノムと口腔内マイクロバイオーム

A 5700 year-old human genome and oral microbiome from chewed birch pitch.
  • Theis Z T Jensen
  • Jonas Niemann
  • Katrine Højholt Iversen
  • Anna K Fotakis
  • Shyam Gopalakrishnan
  • Åshild J Vågene
  • Mikkel Winther Pedersen
  • Mikkel-Holger S Sinding
  • Martin R Ellegaard
  • Morten E Allentoft
  • Liam T Lanigan
  • Alberto J Taurozzi
  • Sofie Holtsmark Nielsen
  • Michael W Dee
  • Martin N Mortensen
  • Mads C Christensen
  • Søren A Sørensen
  • Matthew J Collins
  • M Thomas P Gilbert
  • Martin Sikora
  • Simon Rasmussen
  • Hannes Schroeder
  • Nat Commun.2019 12;10(1):5520. 10.1038/s41467-019-13549-9. doi: 10.1038/s41467-019-13549-9.Epub 2019-12-17.

仕事中のマスタースカルプター。腸原性大腸菌感染症はミトコンドリアのタンパク質分解を特異的に修飾し、ヒト細胞死を制御している

Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death.
  • Natalie C Marshall
  • Maichael Thejoe
  • Theo Klein
  • Antonio Serapio-Palacios
  • Andrew S Santos
  • Niklas von Krosigk
  • Jayachandran N Kizhakkedathu
  • Nikolay Stoynov
  • Leonard J Foster
  • Christopher M Overall
  • B Brett Finlay
  • mSystems.2020 Jun;5(3). e00283-20. doi: 10.1128/mSystems.00283-20.Epub 2020-06-02.

英国のバイオバンクにおけるクローン性造血によって引き起こされた大きなコピー数のバリアントは、浸透率推定を混乱させる可能性があります

Large Copy-Number Variants in UK Biobank Caused by Clonal Hematopoiesis May Confound Penetrance Estimates.
  • Marcus Tuke
  • Jessica Tyrrell
  • Katherine S Ruth
  • Robin N Beaumont
  • Andrew R Wood
  • Anna Murray
  • Timothy M Frayling
  • Michael N Weedon
  • Caroline F Wright
  • Am. J. Hum. Genet..2020 Jun;S0002-9297(20)30189-0. doi: 10.1016/j.ajhg.2020.06.001.Epub 2020-06-17.

COVID-19時代の急性白血病および骨髄性新生物を有する成人患者の管理における特別な考慮事項：国際的な専門家のパネルからの勧告

Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: recommendations from a panel of international experts.
  • Amer M Zeidan
  • Prajwal C Boddu
  • Mrinal M Patnaik
  • Jan Philipp Bewersdorf
  • Maximilian Stahl
  • Raajit K Rampal
  • Rory Shallis
  • David P Steensma
  • Michael R Savona
  • Mikkael A Sekeres
  • Gail J Roboz
  • Daniel J DeAngelo
  • Andre C Schuh
  • Eric Padron
  • Joshua F Zeidner
  • Roland B Walter
  • Francesco Onida
  • Amir Fathi
  • Amy DeZern
  • Gabriela Hobbs
  • Eytan M Stein
  • Paresh Vyas
  • Andrew H Wei
  • David T Bowen
  • Pau Montesinos
  • Elizabeth A Griffiths
  • Amit K Verma
  • Alla Keyzner
  • Michal Bar-Natan
  • Shyamala C Navada
  • Marina Kremyanskaya
  • Aaron D Goldberg
  • Aref Al-Kali
  • Mark L Heaney
  • Aziz Nazha
  • Huda Salman
  • Selina Luger
  • Keith W Pratz
  • Heiko Konig
  • Rami Komrokji
  • Michael Deininger
  • Blanca Xicoy Cirici
  • Vijaya Raj Bhatt
  • Lewis R Silverman
  • Harry P Erba
  • Pierre Fenaux
  • Uwe Platzbecker
  • Valeria Santini
  • Eunice S Wang
  • Martin S Tallman
  • Richard M Stone
  • John Mascarenhas
  • Lancet Haematol.2020 Jun;S2352-3026(20)30205-2. doi: 10.1016/S2352-3026(20)30205-2.Epub 2020-06-18.

ビルバオ（スペイン北部）における性器ヘルペスの特徴：12 年間のレトロスペクティブ研究

Characteristics of genital herpes in Bilbao (Northern Spain): 12-year retrospective study.
  • Mikele Macho-Aizpurua
  • Manuel Imaz-Pérez
  • José Ángel Álava-Menica
  • Leonora Hernández-Ragpa
  • María-Josefina López-de-Munain-López
  • Mari-Mar Cámara-Pérez
  • Amaia Bilbao-González
  • José-Luis Díaz-de-Tuesta-Del Arco
  • Josefa Muñoz-Sánchez
  • Miren Basaras-Ibarzabal
  • Ramon Cisterna-Cancér
  • Enferm. Infecc. Microbiol. Clin..2020 Jun;S0213-005X(20)30198-1. doi: 10.1016/j.eimc.2020.04.014.Epub 2020-06-17.

アラブ首長国連邦の2つの主要な産院における妊娠糖尿病管理、危険因子、母体および新生児の転帰のレビュー。ドバイからの報告である

A review of gestational diabetes mellitus management, risk factors, maternal and neonatal outcomes in two major maternity hospitals in the United Arab Emirates: A report from Dubai.
  • Mahera Abdulrahman
  • Zainabsadat Tabatabaei
  • Sadia Maqbool
  • Khadija Hafidh
  • Zahra Sm Husain
  • Fatima Hussain Al Raeesi
  • Nour Mazen Abo Sada
  • Madiha Akbar
  • Nawal Mahmood Hubaishi
  • Muna Abdul Razzaq Tahlak
  • Frederick Robert Carrick
  • J Neonatal Perinatal Med.2020 Jun;NPM200410. doi: 10.3233/NPM-200410.Epub 2020-06-18.

中皮腫細胞の生存は抗アポトーシスタンパク質Bcl-xLに依存しており、BH3模倣薬により電離放射線に感作されている

Mesothelioma Cells Depend on the Antiapoptotic Protein Bcl-xL for Survival and Are Sensitized to Ionizing Radiation by BH3-Mimetics.
  • Mark R Jackson
  • Miranda Ashton
  • Anna L Koessinger
  • Craig Dick
  • Marcel Verheij
  • Anthony J Chalmers
  • Int. J. Radiat. Oncol. Biol. Phys..2020 03;106(4):867-877. S0360-3016(19)34068-4. doi: 10.1016/j.ijrobp.2019.11.029.Epub 2019-11-28.

グルコセレブロシダーゼ遺伝子変異の有無にかかわらずパーキンソン病患者の治療に対するアンブロキソール。非ランダム化非対照試験

Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial.
  • Stephen Mullin
  • Laura Smith
  • Katherine Lee
  • Gayle D'Souza
  • Philip Woodgate
  • Josh Elflein
  • Jenny Hällqvist
  • Marco Toffoli
  • Adam Streeter
  • Joanne Hosking
  • Wendy E Heywood
  • Rajeshree Khengar
  • Philip Campbell
  • Jason Hehir
  • Sarah Cable
  • Kevin Mills
  • Henrik Zetterberg
  • Patricia Limousin
  • Vincenzo Libri
  • Tom Foltynie
  • Anthony H V Schapira
  • JAMA Neurol.2020 04;77(4):427-434. 2758317. doi: 10.1001/jamaneurol.2019.4611.

グルコシルセラミド関連スフィンゴ脂質はゴーシェ病患者のがんリスク上昇に関与しているか？レビューと仮説

Are Glucosylceramide-Related Sphingolipids Involved in the Increased Risk for Cancer in Gaucher Disease Patients? Review and Hypotheses.
  • Patricia Dubot
  • Leonardo Astudillo
  • Nicole Therville
  • Frédérique Sabourdy
  • Jérôme Stirnemann
  • Thierry Levade
  • Nathalie Andrieu-Abadie
  • Cancers (Basel).2020 Feb;12(2). E475. doi: 10.3390/cancers12020475.Epub 2020-02-18.

脾臓摘出は、肝線維化の際にERK1/2経路を活性化することで、肝マクロファージのLy6C表現型を増強する

Splenectomy enhances the Ly6C phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.
  • Zhongqiang Zheng
  • Huan Wang
  • Liang Li
  • Shaoying Zhang
  • Chunyan Zhang
  • Hailong Zhang
  • Fanpu Ji
  • Xi Liu
  • Kai Zhu
  • Guangyao Kong
  • Zongfang Li
  • Int. Immunopharmacol..2020 Jul;86:106762. S1567-5769(20)31060-2. doi: 10.1016/j.intimp.2020.106762.Epub 2020-07-07.

ステロイド代謝サイトクローム P450 とアビラテロン D4A 代謝物との相互作用：スペクトル解析と分子ドッキング

The interactions of a number of steroid-metabolizing cytochromes P450 with abiraterone D4A metabolite: spectral analysis and molecular docking.
  • Rami A Masamrekh
  • Tatiana A Filippova
  • Yaraslau I Haurychenka
  • Kirill A Sherbakov
  • Alexander V Veselovsky
  • Victoria V Shumyantseva
  • Alexey V Kuzikov
  • Steroids.2020 Jul;162:108693. S0039-128X(20)30119-7. doi: 10.1016/j.steroids.2020.108693.Epub 2020-07-06.

PipeNig-FL、-β-カリオフィレンの高い標準化されたコンテンツを持つ黒胡椒（ L. ）の流体抽出物は、3T3-L1前駆細胞における脂質蓄積を減少させ、C2C12筋管におけるグルコースの取り込みを改善します

PipeNig-FL, a Fluid Extract of Black Pepper ( L.) with a High Standardized Content of -β-Caryophyllene, Reduces Lipid Accumulation in 3T3-L1 Preadipocytes and Improves Glucose Uptake in C2C12 Myotubes.
  • Federica Geddo
  • Rosaria Scandiffio
  • Susanna Antoniotti
  • Erika Cottone
  • Giulia Querio
  • Massimo E Maffei
  • Patrizia Bovolin
  • Maria Pia Gallo
  • Nutrients.2019 Nov;11(11). E2788. doi: 10.3390/nu11112788.Epub 2019-11-15.

アロプレグナノロンは、ラットの学習性無力症うつ病モデルにおいて、AMPA受容体の活性化とは無関係にBDNF-TrkBシグナル伝達を介して抗うつ薬様の効果を誘導する

Allopregnanolone induces antidepressant-like effects through BDNF-TrkB signaling independent from AMPA receptor activation in a rat learned helplessness model of depression.
  • Yukihiko Shirayama
  • Yuko Fujita
  • Yasunori Oda
  • Masaaki Iwata
  • Katsumasa Muneoka
  • Kenji Hashimoto
  • Behav. Brain Res..2020 Jul;390:112670. S0166-4328(20)30369-7. doi: 10.1016/j.bbr.2020.112670.Epub 2020-05-11.

動物実験室における研修医の手術成績に対する構造化された評価と即時フィードバックを組み込んだ集中腹腔鏡トレーニングコースの影響を検討した

The impact of intensive laparoscopic training course with structured assessment and immediate feedback on residents' operative performance in animal lab.
  • Iman Ghaderi
  • Tung Tran
  • Melissa Carton
  • Julia Samamé
  • Carlos Galvani
  • Surg Endosc.2020 Jul;10.1007/s00464-020-07778-z. doi: 10.1007/s00464-020-07778-z.Epub 2020-07-08.

カドミウムへの短期暴露がゼブラフィッシュの嗅覚系を破壊する - 嗅覚器官における遺伝子発現の変化と行動障害の関連性

Short exposure to cadmium disrupts the olfactory system of zebrafish (Danio rerio) - Relating altered gene expression in the olfactory organ to behavioral deficits.
  • Sina N Volz
  • Jonas Hausen
  • Milen Nachev
  • Richard Ottermanns
  • Sabrina Schiwy
  • Henner Hollert
  • Aquat. Toxicol..2020 Jun;226:105555. S0166-445X(20)30305-2. doi: 10.1016/j.aquatox.2020.105555.Epub 2020-06-29.

退行性経カテーテル大動脈弁置換術におけるValve-in-Valveと退行性外科的大動脈バイオプロテーゼにおけるValve-in-Valveの比較。血行動態と1年間の成績を比較した3施設間の比較

Valve-in-Valve for Degenerated Transcatheter Aortic Valve Replacement Versus Valve-in-Valve for Degenerated Surgical Aortic Bioprostheses: A 3-Center Comparison of Hemodynamic and 1-Year Outcome.
  • Matthias C Raschpichler
  • Felix Woitek
  • Tarun Chakravarty
  • Nir Flint
  • Sung-Han Yoon
  • Norman Mangner
  • Chinar G Patel
  • Chetana Singh
  • Mohammad Kashif
  • Philip Kiefer
  • David Holzhey
  • Axel Linke
  • Georg Stachel
  • Holger Thiele
  • Michael A Borger
  • Raj R Makkar
  • J Am Heart Assoc.2020 Jul;:e013973. doi: 10.1161/JAHA.119.013973.Epub 2020-07-09.

リソソームエクソサイトーシス、エクソソソーム放出、分泌性オートファジー：オートファジー系とエンドーリソソーム系の細胞外への展開

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular.
  • Sandra Buratta
  • Brunella Tancini
  • Krizia Sagini
  • Federica Delo
  • Elisabetta Chiaradia
  • Lorena Urbanelli
  • Carla Emiliani
  • Int J Mol Sci.2020 Apr;21(7). E2576. doi: 10.3390/ijms21072576.Epub 2020-04-08.

葉エキスは、L-NAME高血圧ラットから分離された腸間膜動脈床において、内皮依存性の過分極とカルシウムチャネル遮断を介して血管弛緩を誘導した

leaf extract induces vasorelaxation via endothelium-dependent hyperpolarization and calcium channel blockade in mesenteric arterial beds isolated from L-NAME hypertensive rats.
  • Direk Aekthammarat
  • Patchareewan Pannangpetch
  • Panot Tangsucharit
  • Clin. Exp. Hypertens..2020 Aug;42(6):490-501. doi: 10.1080/10641963.2020.1714640.Epub 2020-01-22.

スフィンゴミエリン酵素阻害剤イミプラミンとβ-カリオフィレンの併用により実験的自己免疫性脳脊髄炎（EAE）の治療効果が向上

Combination of Imipramine, a sphingomyelinase inhibitor, and β-caryophyllene improve their therapeutic effects on experimental autoimmune encephalomyelitis (EAE).
  • Vahid Reza Askari
  • Vafa Baradaran Rahimi
  • Seyed Abbas Tabatabaee
  • Reza Shafiee-Nick
  • Int. Immunopharmacol..2019 Dec;77:105923. S1567-5769(19)31596-6. doi: 10.1016/j.intimp.2019.105923.Epub 2019-11-08.

21世紀の微生物学・生態学研究におけるハイスループット真菌エレクトロカルチュロミクスと新しいオミックス方法論を目指して

Toward High-Throughput Fungal Electroculturomics and New Omics Methodologies in 21st-Century Microbiology and Ecology.
  • Andreas Stathoulias
  • Aphroditi Milioni
  • Stavroula Kritikou
  • Aikaterini Karmakolia
  • Stavroula Goudoudaki
  • Stavroula Siamoglou
  • Constantinos Chassomeris
  • Stamatis Vassilakis
  • Kariofyllis Karamperis
  • Aristea Velegraki
  • Cleo Anastassopoulou
  • Yiannis Manoussopoulos
  • George P Patrinos
  • Manousos E Kambouris
  • OMICS.2020 Jun;doi: 10.1089/omi.2020.0012.Epub 2020-06-11.

インプラントの設計と肩峰と肩甲骨棘の歪み上の副矢状の先端形態の影響を逆全肩関節形成術後：死体とコンピュータベースのバイオメカニクス分析

Influence of implant design and parasagittal acromial morphology on acromial and scapular spine strain after reverse total shoulder arthroplasty: a cadaveric and computer-based biomechanical analysis.
  • Sarav S Shah
  • Joseph Gentile
  • Xiang Chen
  • Andreas Kontaxis
  • David M Dines
  • Russell F Warren
  • Samuel A Taylor
  • Amirhossein Jahandar
  • Lawrence V Gulotta
  • J Shoulder Elbow Surg.2020 Jun;S1058-2746(20)30305-0. doi: 10.1016/j.jse.2020.04.004.Epub 2020-06-09.

FTY720-ミトキシは、Multiple System Atrophyマウスモデルにおいて、シヌクレイン症と神経炎症を軽減し、行動とミトコンドリア機能を回復させ、GDNF発現を増加させます

FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models.
  • Guadalupe Vidal-Martinez
  • Ismael Segura-Ulate
  • Barbara Yang
  • Valeria Diaz-Pacheco
  • Jose A Barragan
  • Jocelyn De-Leon Esquivel
  • Stephanie A Chaparro
  • Javier Vargas-Medrano
  • Ruth G Perez
  • Exp. Neurol..2020 Mar;325:113120. S0014-4886(19)30267-5. doi: 10.1016/j.expneurol.2019.113120.Epub 2019-11-18.

小児がんの 5 年生存者 13,457 人における脳血管疾患のリスク：集団ベースのコホート研究

Risk of cerebrovascular disease among 13,457 five-year survivors of childhood cancer: a population based cohort study.
  • Raoul C Reulen
  • Joyeeta Guha
  • Chloe J Bright
  • Katherine E Henson
  • Richard G Feltbower
  • Marlous Hall
  • Julie S Kelly
  • David L Winter
  • Michelle Kwok-Williams
  • Rod Skinner
  • David J Cutter
  • Clare Frobisher
  • Mike M Hawkins
  • Int. J. Cancer.2020 Jul;doi: 10.1002/ijc.33218.Epub 2020-07-19.

上顎洞の悪性腫瘍。138人の患者のシリーズにおける神経血管浸潤の予後への影響

Malignant tumors of the maxillary sinus: Prognostic impact of neurovascular invasion in a series of 138 patients.
  • Marco Ferrari
  • Alessandro Ioppi
  • Alberto Schreiber
  • Tommaso Gualtieri
  • Davide Mattavelli
  • Vittorio Rampinelli
  • Stefano Taboni
  • Michele Tomasoni
  • Paolo Bossi
  • Alberto Deganello
  • Piero Nicolai
  • Oral Oncol..2020 07;106:104672. S1368-8375(20)30108-1. doi: 10.1016/j.oraloncology.2020.104672.Epub 2020-04-13.

合成インターロイキン22（IL-22）シグナル伝達は、ホモ二量体IL-10R2の生物学的活性とIL-6受容体gp130との機能的クロストークを明らかにした

Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10R2 and functional cross-talk with the IL-6 receptor gp130.
  • Sofie Mossner
  • Marcus Kuchner
  • Nastaran Fazel Modares
  • Birgit Knebel
  • Hadi Al-Hasani
  • Doreen M Floss
  • Jürgen Scheller
  • J. Biol. Chem..2020 Jul;jbc.RA120.013927. doi: 10.1074/jbc.RA120.013927.Epub 2020-07-01.

ヒト血管細胞のゲノムプロファイリングにより、TWIST1が一般的な血管疾患の原因遺伝子であることが判明

Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases.
  • Sylvia T Nurnberg
  • Marie A Guerraty
  • Robert C Wirka
  • H Shanker Rao
  • Milos Pjanic
  • Scott Norton
  • Felipe Serrano
  • Ljubica Perisic
  • Susannah Elwyn
  • John Pluta
  • Wei Zhao
  • Stephanie Testa
  • YoSon Park
  • Trieu Nguyen
  • Yi-An Ko
  • Ting Wang
  • Ulf Hedin
  • Sanjay Sinha
  • Yoseph Barash
  • Christopher D Brown
  • Thomas Quertermous
  • Daniel J Rader
  • PLoS Genet..2020 01;16(1):e1008538. PGENETICS-D-19-00403. doi: 10.1371/journal.pgen.1008538.Epub 2020-01-09.

ハルミンは、STZ誘発糖尿病ラットにおけるNLRP3インフラマソーム活性化阻害とBDNF/TrkBシグナル伝達経路の強化により、認知機能障害を改善します

Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats.
  • Peifang Liu
  • Hui Li
  • Yueqiu Wang
  • Xiaolin Su
  • Yang Li
  • Meiling Yan
  • Lan Ma
  • Hui Che
  • Front Pharmacol.2020;11:535. doi: 10.3389/fphar.2020.00535.Epub 2020-05-01.

ストレス性尿失禁の女性を対象としたデュロキセチンと革新的骨盤底筋トレーニングの評価（デュロキシング試験プロトコール臨床試験（SPIRIT準拠）

Evaluation of duloxetine and innovative pelvic floor muscle training in women with stress urinary incontinence (DULOXING): Study protocol clinical trial (SPIRIT Compliant).
  • Magdalena Hagovska
  • Jan Svihra
  • Medicine (Baltimore).2020 Feb;99(6):e18834. 00005792-202002070-00010. doi: 10.1097/MD.0000000000018834.

ミクロ進化からマクロ進化へ：岩の露頭に適応した高個体群の遺伝構造を持つ新熱帯ブロムリアードからの洞察

From micro- to macroevolution: insights from a Neotropical bromeliad with high population genetic structure adapted to rock outcrops.
  • Mateus Ribeiro Mota
  • Fabio Pinheiro
  • Barbara Simões Dos Santos Leal
  • Carla Haisler Sardelli
  • Tânia Wendt
  • Clarisse Palma-Silva
  • Heredity (Edinb).2020 Jul;10.1038/s41437-020-0342-8. doi: 10.1038/s41437-020-0342-8.Epub 2020-07-17.

6-アミノキノリル-N-ヒドロキシスクシンイミジルカルバメートを用いたプレカラム誘導体化による注射剤製剤中のガニレリクス酢酸塩のアミノ酸組成の決定

Determination of Amino Acid Composition of Ganirelix Acetate in an Injectable Formulation by Pre-column Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate.
  • Kumarswamy Ummiti
  • J V Shanmukha Kumar
  • J Chromatogr Sci.2020 Jul;bmaa030. doi: 10.1093/chromsci/bmaa030.Epub 2020-07-17.

社会的敗北を繰り返すと、脾臓ミエロイド細胞の持続的な炎症性変化が促進され、β-arrestin-2（ARRB2）の発現が低下し、インターロイキン-6（IL-6）の発現が増加した

Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of β-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6).
  • Dhaksshaginy Rajalingam
  • Ingeborg Nymoen
  • Daniel Pitz Jacobsen
  • Mina Baarnes Eriksen
  • Erik Dissen
  • Morten Birkeland Nielsen
  • Ståle Valvatne Einarsen
  • Johannes Gjerstad
  • BMC Neurosci.2020 May;21(1):25. 10.1186/s12868-020-00574-4. doi: 10.1186/s12868-020-00574-4.Epub 2020-05-29.

ヒトインターロイキン11α受容体の細胞外ドメインの構造から、サイトカインの関与機構が明らかになった

The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement.
  • Riley D Metcalfe
  • Kaheina Aizel
  • Courtney O Zlatic
  • Paul M Nguyen
  • Craig J Morton
  • Daisy Sio-Seng Lio
  • Heung-Chin Cheng
  • Renwick C J Dobson
  • Michael W Parker
  • Paul R Gooley
  • Tracy L Putoczki
  • Michael D W Griffin
  • J. Biol. Chem..2020 Jun;295(24):8285-8301. RA119.012351. doi: 10.1074/jbc.RA119.012351.Epub 2020-04-24.

サロラネール、モキシデクチン、ピランテルを含有する新規経口チュアブル錠（シンパリカ・トリオ）の、ヨーロッパの動物病院で診察を受けた犬を対象としたノミ・マダニ感染症に対する有効性

Efficacy of a novel oral chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against natural flea and tick infestations on dogs presented as veterinary patients in Europe.
  • Csilla Becskei
  • Daphne Fias
  • Sean P Mahabir
  • Robert Farkas
  • Parasit Vectors.2020 Mar;13(1):72. 10.1186/s13071-020-3946-1. doi: 10.1186/s13071-020-3946-1.Epub 2020-03-01.

多嚢胞性卵巣症候群の女性と正常な排卵コントロールの女性における単一の理想的な胚盤胞を移植した体外受精の結果の比較

A comparison of IVF outcomes transferring a single ideal blastocyst in women with polycystic ovary syndrome and normal ovulatory controls.
  • Naama Steiner
  • Senem Ates
  • Talya Shaulov
  • Guy Shrem
  • Alexander Volodarsky-Perel
  • S Yehuda Dahan
  • Samer Tannus
  • Weon-Young Son
  • Michael H Dahan
  • Arch. Gynecol. Obstet..2020 Jul;10.1007/s00404-020-05699-9. doi: 10.1007/s00404-020-05699-9.Epub 2020-07-15.

また、ポリビニルピロリドン（PVP）で機能化した銀ナノ粒子のBiomphalaria glabrataに対する軟体動物殺虫活性：統合失調症の中間宿主カタツムリの防除への応用についても検討した

Molluscicidal activity of polyvinylpyrrolidone (PVP)-functionalized silver nanoparticles to Biomphalaria glabrata: implications for control of intermediate host snail of schistosomiasis.
  • Paula Sampaio Araújo
  • Maxwell Batista Caixeta
  • Rafaella da Silva Brito
  • Bruno Bastos Gonçalves
  • Sueli Maria da Silva
  • Emília Celma de Oliveira Lima
  • Luciana Damacena Silva
  • José Clecildo Barreto Bezerra
  • Thiago Lopes Rocha
  • Acta Trop..2020 Jul;:105644. S0001-706X(20)30062-0. doi: 10.1016/j.actatropica.2020.105644.Epub 2020-07-16.

フィブリノゲンγ鎖変異はフィブリノゲンとアポリポ蛋白B血漿欠乏症と肝貯蔵を誘発する

Fibrinogen Gamma Chain Mutations Provoke Fibrinogen and Apolipoprotein B Plasma Deficiency and Liver Storage.
  • Francesco Callea
  • Isabella Giovannoni
  • Sinan Sari
  • Esendagli Guldal
  • Buket Dalgic
  • Gulen Akyol
  • Tsuyoshi Sogo
  • Abdulrahman Al-Hussaini
  • Giuseppe Maggiore
  • Andrea Bartuli
  • Renata Boldrini
  • Paola Francalanci
  • Emanuele Bellacchio
  • Int J Mol Sci.2017 Dec;18(12). E2717. doi: 10.3390/ijms18122717.Epub 2017-12-15.

Rhodiola rosea 抽出物が口腔内病原体Streptococcus mutansのバイオフィルム形成と病原性遺伝子の発現を抑制することを明らかにした

Rhodiola rosea extract inhibits the biofilm formation and the expression of virulence genes of cariogenic oral pathogen Streptococcus mutans.
  • Zhong Zhang
  • Yiduo Liu
  • Miao Lu
  • Xiaoying Lyu
  • Tao Gong
  • Boyu Tang
  • Liu Wang
  • Jumei Zeng
  • Yuqing Li
  • Arch. Oral Biol..2020 Aug;116:104762. S0003-9969(20)30140-0. doi: 10.1016/j.archoralbio.2020.104762.Epub 2020-05-19.

性別を肯定するホルモン療法は、トランスメンにおける6ヶ月間の治療後にESR1遺伝子プロモーターのCpGメチル化パターンを変更します

Gender-Affirming Hormone Therapy Modifies the CpG Methylation Pattern of the ESR1 Gene Promoter After Six Months of Treatment in Transmen.
  • Rosa Fernández
  • Karla Ramírez
  • Esther Gómez-Gil
  • Joselyn Cortés-Cortés
  • Mireia Mora
  • Gloria Aranda
  • Enrique Delgado Zayas
  • Isabel Esteva
  • Mari Cruz Almaraz
  • Antonio Guillamon
  • Eduardo Pásaro
  • J Sex Med.2020 Jul;S1743-6095(20)30668-8. doi: 10.1016/j.jsxm.2020.05.027.Epub 2020-07-04.

東南アジアではあまり知られていないマムシ類2種のヘビ毒の毒性と交差中和。この研究では、東南アジアではあまり知られていないマムシ類2種のヘビ毒の毒性と交差中和性について検討した

Toxicity and cross-neutralization of snake venoms from two lesser-known arboreal pit vipers in Southeast Asia: Trimeresurus wiroti and Trimeresurus puniceus.
  • Louisa Pernee Lee
  • Kae Yi Tan
  • Choo Hock Tan
  • Toxicon.2020 Jun;185:91-96. S0041-0101(20)30291-9. doi: 10.1016/j.toxicon.2020.06.012.Epub 2020-06-22.