あなたは歯科・医療関係者ですか？

WHITE CROSSは、歯科・医療現場で働く方を対象に、良質な歯科医療情報の提供を目的とした会員制サイトです。

日本語AIでPubMedを検索

歯科医師情報サイトTOP / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
対象期間    ～ 

2020年07月 みんなが読んでいる論文

BCO1遺伝子のSNP rs6564851は、ガーナの農村部に住む青年たちのプロビタミンA血漿濃度の変動と関連しているが、レチノール濃度とは関連していない

SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana.
  • Sophie Graßmann
  • Olga Pivovarova-Ramich
  • Andrea Henze
  • Jens Raila
  • Yaw Ampem Amoako
  • Richard King Nyamekye
  • George Bedu-Addo
  • Frank P Mockenhaupt
  • Matthias B Schulze
  • Ina Danquah
  • Nutrients.2020 Jun;12(6). E1786. doi: 10.3390/nu12061786.Epub 2020-06-16.

実験ブタにおけるメマンチンの単回及び反復投与による胃筋電活性への影響と薬物動態パラメータの検討

The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs.
  • Jan Bures
  • Jaroslav Kvetina
  • Vera Radochova
  • Ilja Tacheci
  • Eva Peterova
  • David Herman
  • Rafael Dolezal
  • Marcela Kopacova
  • Stanislav Rejchrt
  • Tomas Douda
  • Vit Sestak
  • Ladislav Douda
  • Jana Zdarova Karasova
  • PLoS ONE.2020;15(1):e0227781. PONE-D-19-23618. doi: 10.1371/journal.pone.0227781.Epub 2020-01-24.

血小板リッチ血漿治療後の閉経期および早発閉経女性における妊娠継続をもたらす自然妊娠に関する症例シリーズ

A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment.
  • Konstantinos Pantos
  • Mara Simopoulou
  • Agni Pantou
  • Anna Rapani
  • Petroula Tsioulou
  • Nikolaos Nitsos
  • Stephen Syrkos
  • Athanasios Pappas
  • Michael Koutsilieris
  • Konstantinos Sfakianoudis
  • Cell Transplant.2019 Sep-Oct;28(9-10):1333-1340. doi: 10.1177/0963689719859539.Epub 2019-07-04.

広範囲にわたる臨床的、血清学的、分子学的研究により、アルゼンチンで初めてRhの表現型が報告された

Extensive clinical, serologic and molecular studies lead to the first reported Rh phenotype in Argentina.
  • Nicolás Mufarrege
  • Noelia Franco
  • Carolina Trucco Boggione
  • Carine Arnoni
  • Tatiane de Paula Vendrame
  • Sonia Bartoli
  • Alejandra Ensinck
  • Cintia Principi
  • Melina Lujan Brajovich
  • Stella Mattaloni
  • Bibiana Riquelme
  • Claudia Biondi
  • Lilian Castilho
  • Carlos Cotorruelo
  • Transfusion.2020 Jul;60(7):1373-1377. doi: 10.1111/trf.15792.Epub 2020-05-06.

ニンジン（Daucus carota）におけるブルームレイプの寄生。寄生雑草Phelipanche aegyptiacaとその宿主におけるカロテノイド遺伝子発現とカロテノイド蓄積量の変化

Broomrape infestation in carrot (Daucus carota): Changes in carotenoid gene expression and carotenoid accumulation in the parasitic weed Phelipanche aegyptiaca and its host.
  • Sewar Emran
  • Bhagwat Nawade
  • Mosaab Yahyaa
  • Jackline Abu Nassar
  • Dorothea Tholl
  • Hanan Eizenberg
  • Mwafaq Ibdah
  • Sci Rep.2020 01;10(1):324. 10.1038/s41598-019-57298-7. doi: 10.1038/s41598-019-57298-7.Epub 2020-01-15.

高負荷Gα結合EXEペプチドナノ粒子は、血栓症を予防し、心筋虚血・再灌流傷害からマウスを保護します

High-loading Gα-binding EXE peptide nanoparticles prevent thrombosis and protect mice from cardiac ischemia/reperfusion injury.
  • Aiming Pang
  • Ni Cheng
  • Yujie Cui
  • Yanyan Bai
  • Zhigang Hong
  • M Keegan Delaney
  • Yaping Zhang
  • Claire Chang
  • Can Wang
  • Chang Liu
  • Paola Leon Plata
  • Alexander Zakharov
  • Kasim Kabirov
  • Jalees Rehman
  • Randal A Skidgel
  • Asrar B Malik
  • Ying Liu
  • Aleksander Lyubimov
  • Minyi Gu
  • Xiaoping Du
  • Sci Transl Med.2020 Jul;12(552). eaaz7287. doi: 10.1126/scitranslmed.aaz7287.

球状曲線を有するブタのアテロコラーゲンビトリゲル膜と移植可能な人工角膜内皮移植片の開発と評価

Development and evaluation of porcine atelocollagen vitrigel membrane with a spherical curve and transplantable artificial corneal endothelial grafts.
  • Junko Yoshida
  • Ayumi Oshikata-Miyazaki
  • Seiichi Yokoo
  • Satoru Yamagami
  • Toshiaki Takezawa
  • Shiro Amano
  • Invest. Ophthalmol. Vis. Sci..2014 Jul;55(8):4975-81. iovs.14-14211. doi: 10.1167/iovs.14-14211.Epub 2014-07-15.

亜熱帯の3都市における原因別精神障害に対する温度の影響。中国におけるケースクロスオーバー研究

The effect of temperature on cause-specific mental disorders in three subtropical cities: A case-crossover study in China.
  • Shiyu Zhang
  • Yin Yang
  • XinHui Xie
  • Huan Li
  • Rong Han
  • Jiesheng Hou
  • Jia Sun
  • Zhengmin Min Qian
  • Shaowei Wu
  • Cunrui Huang
  • Steven W Howard
  • Fei Tian
  • WenFeng Deng
  • Hualiang Lin
  • Environ Int.2020 Jul;143:105938. S0160-4120(20)31893-6. doi: 10.1016/j.envint.2020.105938.Epub 2020-07-17.

微小腺腺腺症に生じた唾液腺型乳腺癌。症例報告および臨床病理学的レビュー

Salivary gland-type mammary carcinoma arising in microglandular adenosis: A case report and clinicopathological review of the literature.
  • Victoria Rico
  • Yukiko Shibahara
  • Marjorie Monteiro
  • Elzbieta Slodkowska
  • Samantha Tam
  • Pearl Zaki
  • Carlo De Angelis
  • Edward Chow
  • Katarzyna Joanna Jerzak
  • Cancer Treat Res Commun.2020 May;24:100178. S2468-2942(20)30015-0. doi: 10.1016/j.ctarc.2020.100178.Epub 2020-05-12.

Platon: タンパク質配列ベースのレプリコン分布スコアを利用した短読ドラフトアセンブリにおける細菌プラスミドコンティグの同定と特性評価

Platon: identification and characterization of bacterial plasmid contigs in short-read draft assemblies exploiting protein sequence-based replicon distribution scores.
  • Oliver Schwengers
  • Patrick Barth
  • Linda Falgenhauer
  • Torsten Hain
  • Trinad Chakraborty
  • Alexander Goesmann
  • Microb Genom.2020 Jun;doi: 10.1099/mgen.0.000398.Epub 2020-06-24.

ウイルス性糖タンパク質遺伝子のコドン最適化に基づいてラッサ熱ライブ減衰ワクチン

A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene.
  • Yingyun Cai
  • Chengjin Ye
  • Benson Cheng
  • Aitor Nogales
  • Masaharu Iwasaki
  • Shuiqing Yu
  • Kurt Cooper
  • David X Liu
  • Randy Hart
  • Ricky Adams
  • Tyler Brady
  • Elena N Postnikova
  • Jonathan Kurtz
  • Marisa St Claire
  • Jens H Kuhn
  • Juan Carlos de la Torre
  • Luis Martínez-Sobrido
  • mBio.2020 02;11(1). e00039-20. doi: 10.1128/mBio.00039-20.Epub 2020-02-25.

医師が常駐する地上救急医療はSTEMI患者のドアからバルーンまでの時間を有意に短縮しない：日本の単一救急センターにおける観察的研究

A physician-staffed ground emergency medical service does not significantly shorten door-to-balloon time in patients with STEMI: an observational study in a single emergency center in Japan.
  • Yuki Yoshioka
  • Ryota Teshima
  • Mina Gamo
  • Ryuhei Yoneda
  • Naoki Matsunaga
  • Tadaaki Takada
  • Yasushi Fukuta
  • Koichi Kishi
  • Acute Med Surg.2020 Jan-Dec;7(1):e542. AMS2542. doi: 10.1002/ams2.542.Epub 2020-07-15.

遺伝間領域の再配列に基づくラッサウイルス生ワクチン候補の開発

A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region.
  • Yingyun Cai
  • Masaharu Iwasaki
  • Daisuke Motooka
  • David X Liu
  • Shuiqing Yu
  • Kurt Cooper
  • Randy Hart
  • Ricky Adams
  • Tracey Burdette
  • Elena N Postnikova
  • Jonathan Kurtz
  • Marisa St Claire
  • Chengjin Ye
  • Jens H Kuhn
  • Luis Martínez-Sobrido
  • Juan Carlos de la Torre
  • mBio.2020 03;11(2). e00186-20. doi: 10.1128/mBio.00186-20.Epub 2020-03-24.

グルコース-6-リン酸デヒドロゲナーゼは、Ca1.2と相互作用してCa電流を増加させ、L型カルシウムチャネルの内在性不活性化を減少させる

Glucose-6-phosphate dehydrogenase increases Ca currents by interacting with Ca1.2 and reducing intrinsic inactivation of the L-type calcium channel.
  • Rakhee Gupte
  • Vidhi Dhagia
  • Petra Rocic
  • Rikuo Ochi
  • Sachin A Gupte
  • Am. J. Physiol. Heart Circ. Physiol..2020 Jul;319(1):H144-H158. doi: 10.1152/ajpheart.00727.2019.Epub 2020-05-22.

セファレキシンの皮膚バイオアベイラビリティと抗菌活性を向上させるための熱感応性・生体接着性ナノトランスファーゾームハイドロゲルハイブリッドシステムの開発のための望ましさ機能アプローチ

Desirability function approach for development of a thermosensitive and bioadhesive nanotransfersome-hydrogel hybrid system for enhanced skin bioavailability and antibacterial activity of cephalexin.
  • Sara Salatin
  • Mitra Jelvehgari
  • Drug Dev Ind Pharm.2020 Jul;:1-16. doi: 10.1080/03639045.2020.1788068.Epub 2020-07-07.

化学療法中の顆粒球-コロニー刺激因子の使用とCA27.29と循環腫瘍細胞との関連性-SUCCESS A試験の結果

Use of Granulocyte-colony Stimulating Factor During Chemotherapy and Its Association With CA27.29 and Circulating Tumor Cells-Results From the SUCCESS A Trial.
  • Philip Hepp
  • Peter A Fasching
  • Matthias W Beckmann
  • Tanja Fehm
  • Jessica Salmen
  • Carsten Hagenbeck
  • Bernadette Jäger
  • Peter Widschwendter
  • Nikolaus de Gregorio
  • Fabienne Schochter
  • Sven Mahner
  • Nadia Harbeck
  • Tobias Weissenbacher
  • Ayse-Gül Kurt
  • Thomas W P Friedl
  • Wolfgang Janni
  • Brigitte Rack
  • Clin. Breast Cancer.2018 10;18(5):e1103-e1110. S1526-8209(17)30674-2. doi: 10.1016/j.clbc.2018.06.006.Epub 2018-06-18.

工学的に設計されたヒトカテリシジン抗菌ペプチドはエボラウイルス感染を抑制する

Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection.
  • Yangsheng Yu
  • Christopher L Cooper
  • Guangshun Wang
  • M Jane Morwitzer
  • Krishna Kota
  • Julie P Tran
  • Steven B Bradfute
  • Yan Liu
  • Jiayu Shao
  • Amanda K Zhang
  • Lindsey G Luo
  • St Patrick Reid
  • Steven H Hinrichs
  • Kaihong Su
  • iScience.2020 Mar;23(4):100999. S2589-0042(20)30183-8. doi: 10.1016/j.isci.2020.100999.Epub 2020-03-22.

ボロン酸で機能化した親水性表面を持つメソポーラス磁性粒子を用いて、糖プロテオミクスのための糖ペプチドのマルチモーダル濃縮を目指します

Boronic acid-functionalized mesoporous magnetic particles with a hydrophilic surface for the multimodal enrichment of glycopeptides for glycoproteomics.
  • Lujie Yang
  • Quanqing Zhang
  • Yuanyu Huang
  • Ling Lin
  • Hartmut Schlüter
  • Ke Wang
  • Cuiping Zhang
  • Pengyuan Yang
  • Hongxiu Yu
  • Analyst.2020 Jul;doi: 10.1039/d0an00648c.Epub 2020-07-03.

ナノ構造カーボンベース電気化学（バイオ）センサーの水域および水生生物中の新たな医薬品汚染物質のスクリーニングへの応用.A Review

Application of Nanostructured Carbon-Based Electrochemical (Bio)Sensors for Screening of Emerging Pharmaceutical Pollutants in Waters and Aquatic Species: A Review.
  • Álvaro Torrinha
  • Thiago M B F Oliveira
  • Francisco W P Ribeiro
  • Adriana N Correia
  • Pedro Lima-Neto
  • Simone Morais
  • Nanomaterials (Basel).2020 Jun;10(7). E1268. doi: 10.3390/nano10071268.Epub 2020-06-29.

ドイツにおける片頭痛患者の行政的有病率と罹患率，特徴，処方パターン：レトロスペクティブなクレームデータ分析

Administrative prevalence and incidence, characteristics and prescription patterns of patients with migraine in Germany: a retrospective claims data analysis.
  • Tatjana Roessler
  • Juergen Zschocke
  • Anne Roehrig
  • Michael Friedrichs
  • Heiko Friedel
  • Zaza Katsarava
  • J Headache Pain.2020 Jul;21(1):85. 10.1186/s10194-020-01154-x. doi: 10.1186/s10194-020-01154-x.Epub 2020-07-06.

血管内皮受容体チロシンホスファターゼ：EPHB4およびTIE2との接合体および三元複合体に関連する新規基質の同定

Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2.
  • Hannes C A Drexler
  • Matthias Vockel
  • Christian Polaschegg
  • Maike Frye
  • Kevin Peters
  • Dietmar Vestweber
  • Mol. Cell Proteomics.2019 10;18(10):2058-2077. RA119.001716. doi: 10.1074/mcp.RA119.001716.Epub 2019-08-19.

Lactobacillus rhamnosus 2016SWU.05.0601は、免疫関連転写因子および腸内細菌叢の発現を調節することにより、オーバルブミンに感作されたマウスにおける免疫バランスを調節する

Lactobacillus rhamnosus 2016SWU.05.0601 regulates immune balance in ovalbumin-sensitized mice by modulating expression of the immune-related transcription factors and gut microbiota.
  • Jiajia Song
  • Yang Li
  • Jian Li
  • Hongwei Wang
  • Yu Zhang
  • Huayi Suo
  • J. Sci. Food Agric..2020 Jun;doi: 10.1002/jsfa.10554.Epub 2020-06-01.

歯科医師が口腔癌や口腔内潜在的悪性病変の早期発見に用いる手がかり：全国歯科診療連携研究ネットワークからの知見

Cues used by dentists in the early detection of oral cancer and oral potentially malignant lesions: findings from the National Dental Practice-Based Research Network.
  • Alexander Ross Kerr
  • Michael E Robinson
  • Cyril Meyerowitz
  • Douglas E Morse
  • Maria L Aguilar
  • Scott L Tomar
  • Lisa Guerrero
  • Dianne Caprio
  • Linda M Kaste
  • Sonia K Makhija
  • Rahma Mungia
  • Linda Rasubala
  • Walter J Psoter
  • Oral Surg Oral Med Oral Pathol Oral Radiol.2020 May;S2212-4403(20)31011-7. doi: 10.1016/j.oooo.2020.05.007.Epub 2020-05-23.

ソヤサポニンIIは、マウスのYB-1リン酸化とNlrp3-inflammasomeプライミングを減少させることにより、急性肝不全を予防します

Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice.
  • Fangzhao Wang
  • Shenhai Gong
  • Teng Wang
  • Lei Li
  • Haihua Luo
  • Junhao Wang
  • Chenyang Huang
  • Hongwei Zhou
  • Guiming Chen
  • Zhanguo Liu
  • Qifan Zhang
  • Yong Jiang
  • Peng Chen
  • Theranostics.2020;10(6):2714-2726. thnov10p2714. doi: 10.7150/thno.40128.Epub 2020-02-03.

Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial（CAVEAT）。修正集中化学療法とベネトグラックス併用の第Ib相用量漸増試験

Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT): A Phase Ib Dose-Escalation Study of Venetoclax Combined With Modified Intensive Chemotherapy.
  • Chong Chyn Chua
  • Andrew W Roberts
  • John Reynolds
  • Chun Yew Fong
  • Stephen B Ting
  • Jessica M Salmon
  • Sarah MacRaild
  • Adam Ivey
  • Ing Soo Tiong
  • Shaun Fleming
  • Fiona C Brown
  • Sun Loo
  • Ian J Majewski
  • Stefan K Bohlander
  • Andrew H Wei
  • J. Clin. Oncol..2020 Jul;:JCO2000572. doi: 10.1200/JCO.20.00572.Epub 2020-07-20.

YBX1ホモログYPSは、5-メチルシトシンRNAを優先的に認識することで卵巣生殖細胞幹細胞の発生を促進する

YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs.
  • Fan Zou
  • Renjun Tu
  • Bo Duan
  • Zhenlin Yang
  • Zhaohua Ping
  • Xiaoqing Song
  • Shiyuan Chen
  • Andrew Price
  • Hua Li
  • Allison Scott
  • Anoja Perera
  • Sisi Li
  • Ting Xie
  • Proc. Natl. Acad. Sci. U.S.A..2020 02;117(7):3603-3609. 1910862117. doi: 10.1073/pnas.1910862117.Epub 2020-02-03.

ヒト免疫不全ウイルスおよびC型肝炎ウイルスに感染した患者における動脈硬化性心血管系イベント

Atherosclerotic Cardiovascular Events in Patients Infected With Human Immunodeficiency Virus and Hepatitis C Virus.
  • Boun Kim Tan
  • Mathieu Chalouni
  • Dominique Salmon Ceron
  • Alexandre Cinaud
  • Laure Esterle
  • Marc Arthur Loko
  • Christine Katlama
  • Isabelle Poizot-Martin
  • Didier Neau
  • Julie Chas
  • Philippe Morlat
  • Eric Rosenthal
  • Karine Lacombe
  • Alissa Naqvi
  • Karl Barange
  • Olivier Bouchaud
  • Anne Gervais
  • Caroline Lascoux-Combe
  • Daniel Garipuy
  • Laurent Alric
  • Cécile Goujard
  • Patrick Miailhes
  • Hugues Aumaitre
  • Claudine Duvivier
  • Anne Simon
  • Jose-Luis Lopez-Zaragoza
  • David Zucman
  • François Raffi
  • Estibaliz Lazaro
  • David Rey
  • Lionel Piroth
  • François Boué
  • Camille Gilbert
  • Firouzé Bani-Sadr
  • François Dabis
  • Philippe Sogni
  • Linda Wittkop
  • Franck Boccara
  • Clin. Infect. Dis..2020 Jul;ciaa1014. doi: 10.1093/cid/ciaa1014.Epub 2020-07-20.

アペリンは、アペリン受容体、プロテインキナーゼA、細胞外シグナル制御キナーゼ1/2活性化を介して、ヒトトロフォブラストBeWo細胞による胎盤ホルモン分泌を減少させた

Apelin decreased placental hormoine secretion by human trophoblast BeWo cells via apelin receptor, protein kinase A and extracellular signal-regulated kinases 1/2 activation.
  • M Dawid
  • E Mlyczynska
  • P Kurowska
  • M Sierpowski
  • A Rak
  • J. Physiol. Pharmacol..2019 Dec;70(6). doi: 10.26402/jpp.2019.6.08.Epub 2020-02-19.

P21の組換え型は宿主の免疫応答を調節することで感染を制御している

The Recombinant Form of P21 Controls Infection by Modulating Host Immune Response.
  • Flávia Alves Martins
  • Marlus Alves Dos Santos
  • Júlia de Gouveia Santos
  • Aline Alves da Silva
  • Bruna Cristina Borges
  • Mylla Spirandelli da Costa
  • Paula Cristina Brígido Tavares
  • Samuel Cota Teixeira
  • Rebecca Tavares E Silva Brígido
  • Thaise Lara Teixeira
  • Cassiano Costa Rodrigues
  • Nadjania Saraiva de Lira Silva
  • Rayane Cristina de Oliveira
  • Laura Caroline de Faria
  • Marcela Rezende Lemes
  • Renata Graciele Zanon
  • Tatiana Carla Tomiosso
  • Juliana Reis Machado
  • Marcos Vinicius da Silva
  • Carlo José Freire Oliveira
  • Claudio Vieira da Silva
  • Front Immunol.2020;11:1010. doi: 10.3389/fimmu.2020.01010.Epub 2020-06-05.

イリ科植物のファイトケミカル組成とインビトロ生物学的活性.口腔内細菌バイオフィルムの抑制のための新たな生理活性成分の供給源

Phytochemical Composition and In Vitro Biological Activity of spp. (Iridaceae): A New Source of Bioactive Constituents for the Inhibition of Oral Bacterial Biofilms.
  • Lan Hoang
  • František Beneš
  • Marie Fenclová
  • Olga Kronusová
  • Viviana Švarcová
  • Kateřina Řehořová
  • Eva Baldassarre Švecová
  • Miroslav Vosátka
  • Jana Hajšlová
  • Petr Kaštánek
  • Jitka Viktorová
  • Tomáš Ruml
  • Antibiotics (Basel).2020 Jul;9(7). E403. doi: 10.3390/antibiotics9070403.Epub 2020-07-11.

2つの木材腐朽菌Ganoderma applanatumとLaetiporus sulphureusによるNSAIDsの新規コビマス分解。リグニン分解酵素の誘導、等温および速度論的研究

Novel cobiomass degradation of NSAIDs by two wood rot fungi, Ganoderma applanatum and Laetiporus sulphureus: Ligninolytic enzymes induction, isotherm and kinetic studies.
  • Paul Olusegun Bankole
  • Adedotun Adeyinka Adekunle
  • Byong-Hun Jeon
  • Sanjay Prabhu Govindwar
  • Ecotoxicol. Environ. Saf..2020 Jul;203:110997. S0147-6513(20)30836-8. doi: 10.1016/j.ecoenv.2020.110997.Epub 2020-07-16.

Alinity m HIV-1アッセイの性能の多施設臨床比較評価

Multicenter clinical comparative evaluation of Alinity m HIV-1 assay performance.
  • Patrick Braun
  • Allison Glass
  • Leana Maree
  • Maria Krügel
  • Monia Pacenti
  • Francesco Onelia
  • Rory Gunson
  • Emily Goldstein
  • Laura Martínez-García
  • Juan-Carlos Galán
  • Alba Vilas
  • Jodie D'costa
  • Rizmina Sameer
  • Robert Ehret
  • Heribert Knechten
  • Gudrun Naeth
  • Magali Bouvier-Alias
  • Natalia Marlowe
  • Michael J Palm
  • Ajith M Joseph
  • Jens Dhein
  • Birgit Reinhardt
  • Karin Pfeifer
  • Danijela Lucic
  • Martin Obermeier
  • J. Clin. Virol..2020 Jul;129:104530. S1386-6532(20)30272-9. doi: 10.1016/j.jcv.2020.104530.Epub 2020-07-03.

CTGリピート選択的化学スクリーニングにより、微小管阻害剤が有毒CUG RNAレベルの選択的調節因子として同定された

A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels.
  • Kaalak Reddy
  • Jana R Jenquin
  • Ona L McConnell
  • John D Cleary
  • Jared I Richardson
  • Belinda S Pinto
  • Maja C Haerle
  • Elizabeth Delgado
  • Lori Planco
  • Masayuki Nakamori
  • Eric T Wang
  • J Andrew Berglund
  • Proc. Natl. Acad. Sci. U.S.A..2019 10;116(42):20991-21000. 1901893116. doi: 10.1073/pnas.1901893116.Epub 2019-09-30.

SARS-CoV-2感染後の急性低運動性硬直症候群

Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection.
  • Antonio Méndez-Guerrero
  • María Isabel Laespada-García
  • Adolfo Gómez-Grande
  • Mariano Ruiz-Ortiz
  • Víctor Antonio Blanco-Palmero
  • Francisco Javier Azcarate-Diaz
  • Pablo Rábano-Suárez
  • Eva Álvarez-Torres
  • Carlos Pablo de Fuenmayor-Fernández de la Hoz
  • Diana Vega Pérez
  • Raquel Rodríguez-Montalbán
  • Alfredo Pérez-Rivilla
  • Javier Sayas Catalán
  • Ana Ramos- González
  • Jesús González de la Aleja
  • Neurology.2020 Jul;10.1212/WNL.0000000000010282. doi: 10.1212/WNL.0000000000010282.Epub 2020-07-08.

Baicalinは、RhoA-ROCK経路を介してTh1およびTh17応答を抑制し、Treg応答を促進することで、敗血症に伴う膵臓損傷を改善することが示唆された

Baicalin suppresses Th1 and Th17 responses and promotes Treg response to ameliorate sepsis-associated pancreatic injury via the RhoA-ROCK pathway.
  • Pingping Liu
  • Zhenghui Xiao
  • Haipeng Yan
  • Xiulan Lu
  • Xinping Zhang
  • Lan Luo
  • Caixia Long
  • Yimin Zhu
  • Int. Immunopharmacol..2020 Jun;86:106685. S1567-5769(20)30273-3. doi: 10.1016/j.intimp.2020.106685.Epub 2020-06-19.

単細胞トランスクリプトミクスは、上咽頭癌の予後に関連する免疫細胞の多様性と免疫サブタイプの根底にある制御因子を明らかにした

Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.
  • Yu-Pei Chen
  • Jian-Hua Yin
  • Wen-Fei Li
  • Han-Jie Li
  • Dong-Ping Chen
  • Cui-Juan Zhang
  • Jia-Wei Lv
  • Ya-Qin Wang
  • Xiao-Min Li
  • Jun-Yan Li
  • Pan-Pan Zhang
  • Ying-Qin Li
  • Qing-Mei He
  • Xiao-Jing Yang
  • Yuan Lei
  • Ling-Long Tang
  • Guan-Qun Zhou
  • Yan-Ping Mao
  • Chen Wei
  • Ke-Xu Xiong
  • Hong-Bo Zhang
  • Shi-Da Zhu
  • Yong Hou
  • Ying Sun
  • Michael Dean
  • Ido Amit
  • Kui Wu
  • Dong-Ming Kuang
  • Gui-Bo Li
  • Na Liu
  • Jun Ma
  • Cell Res..2020 Jul;10.1038/s41422-020-0374-x. doi: 10.1038/s41422-020-0374-x.Epub 2020-07-20.

妊娠糖尿病の予測因子としての皮下脂肪および内臓脂肪の超音波評価：システマティックレビュー

Ultrasound evaluation of subcutaneous and visceral abdominal fat as a predictor of gestational diabetes mellitus: a systematic review.
  • Fernanda Teixeira Benevides
  • Edward Araujo Júnior
  • Carla Soraya Costa Maia
  • Renan Magalhães Montenegro Junior
  • Francisco Herlânio Costa Carvalho
  • J. Matern. Fetal. Neonatal. Med..2020 Jun;:1-11. doi: 10.1080/14767058.2020.1781808.Epub 2020-06-21.

Joubert Syndromeにおける網膜電図検査。将来の標的治療の有効性を評価するための提案された客観的方法

Electroretinographic Assessment in Joubert Syndrome: A Suggested Objective Method to Evaluate the Effectiveness of Future Targeted Treatment.
  • Giulio Ruberto
  • Vincenzo Parisi
  • Chiara Bertone
  • Sabrina Signorini
  • Mauro Antonini
  • Enza Maria Valente
  • Federica Manzoni
  • Valentina Serpieri
  • Riccardo Fausto
  • Luciano Quaranta
  • Adv Ther.2020 Jul;10.1007/s12325-020-01432-9. doi: 10.1007/s12325-020-01432-9.Epub 2020-07-15.

ウイルスモニタリングのための磁性誘導性微小電極の設計：B型肝炎ウイルスのためのモデル化と実現可能性

Designing a magnetic inductive micro-electrode for virus monitoring: modelling and feasibility for hepatitis B virus.
  • Elias Alipour
  • Seyed Peyman Shariatpanahi
  • Hedayatollah Ghourchian
  • Benoit Piro
  • Morteza Fathipour
  • Seyed Mehdi Boutorabi
  • Sergey L Znoyko
  • Petr I Nikitin
  • Mikrochim Acta.2020 Jul;187(8):463. 10.1007/s00604-020-04429-x. doi: 10.1007/s00604-020-04429-x.Epub 2020-07-20.

アリニティーm HCVアッセイの性能の多施設臨床評価

Multicenter clinical evaluation of alinity m HCV assay performance.
  • Stéphane Chevaliez
  • Francesco Onelia
  • Monia Pacenti
  • Emily Goldstein
  • Juan-Carlos Galán
  • Laura Martínez-García
  • Alba Vilas
  • Allison Glass
  • Leana Maree
  • Maria Krügel
  • Robert Ehret
  • Heribert Knechten
  • Patrick Braun
  • Gudrun Naeth
  • Sara Bonanzinga
  • Kathy Jackson
  • Klara Abravaya
  • Jens Dhein
  • Shihai Huang
  • Ajith M Joseph
  • Danijela Lucic
  • Natalia Marlowe
  • Michael J Palm
  • Karin Pfeifer
  • Dan Toolsie
  • Birgit Reinhardt
  • Martin Obermeier
  • Rory Gunson
  • J. Clin. Virol..2020 Jul;129:104531. S1386-6532(20)30273-0. doi: 10.1016/j.jcv.2020.104531.Epub 2020-07-03.

MRI陰性の巣状皮質異形成IIB型患者における高度動的統計パラメトリックマッピングと脳磁図法を用いたてんかん原性焦点の検出

Detection of epileptogenic focus using advanced dynamic statistical parametric mapping with magnetoencephalography in a patient with MRI-negative focal cortical dysplasia type IIB.
  • Won Seok Chang
  • Midori Nakajima
  • Ayako Ochi
  • Elysa Widjaja
  • James T Rutka
  • Ivanna Yau
  • Shiro Baba
  • Hiroshi Otsubo
  • J Neurosurg Pediatr.2019 Oct;:1-5. 2019.7.PEDS1948. doi: 10.3171/2019.7.PEDS1948.Epub 2019-10-11.

N-パルミトイル-O-ホスホコリン-セリンとスフィンゴシルホスホリルコリンの同時液体クロマトグラフィー/タンデム質量分析に基づくニーマンピック病の診断スクリーニング法の開発

Development of a diagnostic screening strategy for Niemann-Pick diseases based on simultaneous liquid chromatography/tandem mass spectrometry analyses of N-palmitoyl-O-phosphocholine-serine and sphingosylphosphorylcholine.
  • Anna Iwahori
  • Masamitsu Maekawa
  • Aya Narita
  • Akie Kato
  • Toshihiro Sato
  • Jiro Ogura
  • Yu Sato
  • Masafumi Kikuchi
  • Atsuko Noguchi
  • Katsumi Higaki
  • Torayuki Okuyama
  • Tsutomu Takahashi
  • Yoshikatsu Eto
  • Nariyasu Mano
  • Biol. Pharm. Bull..2020 Jun;doi: 10.1248/bpb.b20-00400.Epub 2020-06-25.

小児、青年、若年成人における薬剤耐性てんかん治療におけるペランパネルの有効性と血清中濃度：12歳未満と12歳以上の患者の比較

Efficacy and serum concentrations of perampanel for treatment of drug-resistant epilepsy in children, adolescents, and young adults: comparison of patients younger and older than 12 years.
  • Satoru Ikemoto
  • Shin-Ichiro Hamano
  • Yuko Hirata
  • Ryuki Matsuura
  • Reiko Koichihara
  • Seizure.2019 Dec;73:75-78. S1059-1311(19)30136-0. doi: 10.1016/j.seizure.2019.10.023.Epub 2019-11-05.

冠動脈疾患治療のための5-リポキシゲナーゼ活性化蛋白質阻害剤の新規化学シリーズの開発

Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease.
  • Malin Lemurell
  • Johan Ulander
  • Hans Emtenäs
  • Susanne Winiwarter
  • Johan Broddefalk
  • Marianne Swanson
  • Martin A Hayes
  • Luna Prieto Garcia
  • Annika Westin Eriksson
  • Johan Meuller
  • Johan Cassel
  • Gabrielle Saarinen
  • Zhong-Qing Yuan
  • Christian Löfberg
  • Staffan Karlsson
  • Monica Sundqvist
  • Carl Whatling
  • J. Med. Chem..2019 05;62(9):4325-4349. doi: 10.1021/acs.jmedchem.8b02012.Epub 2019-04-15.

前立腺閉塞症良性疾患に対するUNBLOCSランダム化比較試験における前立腺の経尿道的切除術対チュリウムレーザー経尿道的気化切除術のCost-Effectiveness

The Cost-Effectiveness of Transurethral resection of the prostate versus Thulium laser transurethral vaporesection of the prostate in the UNBLOCS randomised controlled trial for benign prostatic obstruction.
  • S M Noble
  • A M Ahern
  • J Worthington
  • H Hashim
  • H Taylor
  • G J Young
  • S Brookes
  • P Abrams
  • L Johnson
  • R Khan
  • T Page
  • S Swami
  • J A Lane
  • BJU Int..2020 Jun;doi: 10.1111/bju.15138.Epub 2020-06-17.

HIV感染者におけるcART開始後の治療変更：ドイツClinSurv HIVコホート2005-2017のレトロスペクティブ分析

Treatment modification after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005-2017.
  • Melanie Stecher
  • Philipp Schommers
  • Christian Kollan
  • Matthias Stoll
  • Frieder Kuhlendahl
  • Hans-Jürgen Stellbrink
  • Jan-Christian Wasmuth
  • Christoph Stephan
  • Laura Hamacher
  • Clara Lehmann
  • Christoph Boesecke
  • Johannes Bogner
  • Stefan Esser
  • Carlos Fritzsche
  • Annette Haberl
  • Christian Hoffmann
  • Björn Jensen
  • Carolynne Schwarze-Zander
  • Martin Platten
  • Gerd Fätkenheuer
  • Daniel Schmidt
  • Barbara Gunsenheimer-Bartmeyer
  • Jörg Janne Vehreschild
  • Infection.2020 Jul;10.1007/s15010-020-01469-6. doi: 10.1007/s15010-020-01469-6.Epub 2020-07-01.

Toll-like Receptor 4 (TLR4)の遮断は、高グルコースに曝露されたライディッヒ細胞において酸化ストレスを軽減し、phospho-ERK1/2レベルを回復させます

Blockade of Toll-like receptor 4 (TLR4) reduces oxidative stress and restores phospho-ERK1/2 levels in Leydig cells exposed to high glucose.
  • Tatiana Karpova
  • Amanda Almeida de Oliveira
  • Huda Naas
  • Fernanda Priviero
  • Kenia Pedrosa Nunes
  • Life Sci..2020 Mar;245:117365. S0024-3205(20)30112-0. doi: 10.1016/j.lfs.2020.117365.Epub 2020-01-27.

フェニル-2,4,6-トリメチルベンゾイルホスフィン酸リチウムで光重合したゼラチンメタクリロイル系ハイドロゲルのヒト初代腎近位尿細管上皮細胞における毒性と光増感性の評価

Toxicity and photosensitizing assessment of gelatin methacryloyl-based hydrogels photoinitiated with lithium phenyl-2,4,6-trimethylbenzoylphosphinate in human primary renal proximal tubule epithelial cells.
  • Alexander K Nguyen
  • Peter L Goering
  • Vytas Reipa
  • Roger J Narayan
  • Biointerphases.2019 05;14(2):021007. doi: 10.1116/1.5095886.Epub 2019-05-03.

腫瘍細胞株のプロテオーム活性のランドスケープが薬物反応を決定する

Proteome activity landscapes of tumor cell lines determine drug responses.
  • Martin Frejno
  • Chen Meng
  • Benjamin Ruprecht
  • Thomas Oellerich
  • Sebastian Scheich
  • Karin Kleigrewe
  • Enken Drecoll
  • Patroklos Samaras
  • Alexander Hogrebe
  • Dominic Helm
  • Julia Mergner
  • Jana Zecha
  • Stephanie Heinzlmeir
  • Mathias Wilhelm
  • Julia Dorn
  • Hans-Michael Kvasnicka
  • Hubert Serve
  • Wilko Weichert
  • Bernhard Kuster
  • Nat Commun.2020 Jul;11(1):3639. 10.1038/s41467-020-17336-9. doi: 10.1038/s41467-020-17336-9.Epub 2020-07-20.

プロテオームとタンパク質のリン酸化の変化は、ポプラ植物のカドミウム毒性を緩和するための外因性窒素の保護的役割を明らかにした

Changes in Proteome and Protein Phosphorylation Reveal the Protective Roles of Exogenous Nitrogen in Alleviating Cadmium Toxicity in Poplar Plants.
  • Jinliang Huang
  • Xiaolu Wu
  • Feifei Tian
  • Qi Chen
  • Pengrui Luo
  • Fan Zhang
  • Xueqin Wan
  • Yu Zhong
  • Qinglin Liu
  • Tiantian Lin
  • Int J Mol Sci.2019 Dec;21(1). E278. doi: 10.3390/ijms21010278.Epub 2019-12-31.

アフリカにおける COVID-19 パンデミック時の定期的な小児予防接種：SARS-CoV-2 感染の過剰リスクと健康上の利益の便益リスク分析

Routine childhood immunisation during the COVID-19 pandemic in Africa: a benefit-risk analysis of health benefits versus excess risk of SARS-CoV-2 infection.
  • Kaja Abbas
  • Simon R Procter
  • Kevin van Zandvoort
  • Andrew Clark
  • Sebastian Funk
  • Tewodaj Mengistu
  • Dan Hogan
  • Emily Dansereau
  • Mark Jit
  • Stefan Flasche
  • Lancet Glob Health.2020 Jul;S2214-109X(20)30308-9. doi: 10.1016/S2214-109X(20)30308-9.Epub 2020-07-17.

ポリ(2-ヒドロキシエチルメタクリレート)をベースとした複合非晶質固体分散体。親水性不溶性高分子担体からの薬物放出に関する研究（多孔質化剤の存在下および非存在下での研究

Complex amorphous solid dispersions based on poly(2-hydroxyethyl methacrylate): Study of drug release from a hydrophilic insoluble polymeric carrier in the presence and absence of a porosity increasing agent.
  • Melissa Everaerts
  • Guy Van den Mooter
  • Int J Pharm.2019 Jul;566:77-88. S0378-5173(19)30399-0. doi: 10.1016/j.ijpharm.2019.05.040.Epub 2019-05-16.

孵化したばかりの日本のメダカにおける転写応答は、希釈アスファルト曝露後の発生奇形と関連している

Transcriptional responses in newly-hatched Japanese medaka (Oryzias latipes) associated with developmental malformations following diluted bitumen exposure.
  • Barry N Madison
  • Sarah J Wallace
  • Jing Zhang
  • Peter V Hodson
  • Valerie S Langlois
  • Comp. Biochem. Physiol. Part D Genomics Proteomics.2020 May;35:100685. S1744-117X(20)30032-0. doi: 10.1016/j.cbd.2020.100685.Epub 2020-05-06.

新しい近赤外ハイパースペクトルイメージング（NIR-HSI）法を用いて、水生サンプル中の微小なマイクロプラスチックを迅速かつ直接検出する

Rapid and direct detection of small microplastics in aquatic samples by a new near infrared hyperspectral imaging (NIR-HSI) method.
  • Stefania Piarulli
  • Giorgia Sciutto
  • Paolo Oliveri
  • Cristina Malegori
  • Silvia Prati
  • Rocco Mazzeo
  • Laura Airoldi
  • Chemosphere.2020 Jul;260:127655. S0045-6535(20)31850-6. doi: 10.1016/j.chemosphere.2020.127655.Epub 2020-07-10.

顎関節症を伴う若年性特発性関節炎における疼痛および開口部に対する関節内コルチコステロイド注射の効果。システマティックレビューとメタアナリシス

Effect of intra-articular corticosteroid injections on pain and mouth opening in juvenile idiopathic arthritis with temporomandibular involvement: A systematic review and meta-analysis.
  • Gregory S Antonarakis
  • Adrien Blanc
  • Delphine S Courvoisier
  • Paolo Scolozzi
  • J Craniomaxillofac Surg.2020 Jun;S1010-5182(20)30155-4. doi: 10.1016/j.jcms.2020.06.010.Epub 2020-06-27.

低磁場磁気共鳴イメージングを用いた流体減衰反転回復シーケンス上の酸素誘発性イヌ脳脊髄液の高輝度化の低減のための適切な霊感酸素の割合

Proper fraction of inspired oxygen for reduction of oxygen-induced canine cerebrospinal fluid hyperintensity on fluid attenuation inversion recovery sequence using low-field magnetic resonance imaging.
  • Moonjung Jang
  • Jaewoo Hwang
  • Jihye Nam
  • Dalhae Kim
  • Wongyun Son
  • Inhyung Lee
  • Mincheol Choi
  • Junghee Yoon
  • J. Vet. Med. Sci..2020 Jul;doi: 10.1292/jvms.20-0060.Epub 2020-07-20.

消化管の神経内分泌がんと神経内分泌非神経内分泌混合新生物は予後が同じ？12,878例のデータベース解析

Do neuroendocrine carcinomas and mixed neuroendocrine-non-neuroendocrine neoplasm of the gastrointestinal tract have the same prognosis? A database analysis of 12,878 cases.
  • Huiying Shi
  • Cuihua Qi
  • Lingjun Meng
  • Hailing Yao
  • Chen Jiang
  • Mengke Fan
  • Suya Pang
  • Qin Zhang
  • Rong Lin
  • Ther Adv Endocrinol Metab.2020;11:2042018820938304. 10.1177_2042018820938304. doi: 10.1177/2042018820938304.Epub 2020-07-06.

ヒト免疫不全ウイルスの母子感染予防のための非ヌクレオシド系逆転写抑制剤-高活性抗レトロウイルス療法の効果には治療経験と妊娠の繰り返しが影響する

Treatment Experience and Repeat Pregnancy Impact the Effectiveness of Non-Nucleoside Reverse Transcription Inhibitor-Highly Active Antiretroviral Therapy for the Prevention of Mother to Child Transmission of Human Immunodeficiency Virus.
  • Indira B Martin
  • Stanley Read
  • Richard Harrigan
  • M Perry Gomez
  • AIDS Res. Hum. Retroviruses.2020 Jun;doi: 10.1089/AID.2019.0001.Epub 2020-06-09.

北極・南極海堆積物中のポリ塩化ジベンゾ-p-ダイオキシン類とジベンゾフラン類の前駆体。気候変動に直面した環境問題

Precursors of polychlorinated dibenzo-p-dioxins and dibenzofurans in Arctic and Antarctic marine sediments: Environmental concern in the face of climate change.
  • Marta Ewelina Kobusińska
  • Krzysztof Konrad Lewandowski
  • Anna Panasiuk
  • Leszek Łęczyński
  • Magdalena Urbaniak
  • Tadeusz Ossowski
  • Elżbieta Niemirycz
  • Chemosphere.2020 Jul;260:127605. S0045-6535(20)31800-2. doi: 10.1016/j.chemosphere.2020.127605.Epub 2020-07-10.

酵母を用いたスクリーニングにより、ニーマンピック病タイプCで影響を受ける細胞経路が明らかになった

Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C.
  • Alexandria Colaco
  • María E Fernández-Suárez
  • Dawn Shepherd
  • Lihi Gal
  • Chen Bibi
  • Silvia Chuartzman
  • Alan Diot
  • Karl Morten
  • Emily Eden
  • Forbes D Porter
  • Joanna Poulton
  • Nick Platt
  • Maya Schuldiner
  • Frances M Platt
  • Life Sci Alliance.2020 Jul;3(7). e201800253. doi: 10.26508/lsa.201800253.Epub 2020-06-02.

全ゲノムシークエンシングにより解決された進行性偽リウマチ性異形成：WISP3の新規変異と文献のレビュー

Progressive Pseudorheumatoid Dysplasia resolved by whole exome sequencing: a novel mutation in WISP3 and review of the literature.
  • Ben Pode-Shakked
  • Asaf Vivante
  • Ortal Barel
  • Shai Padeh
  • Dina Marek-Yagel
  • Alvit Veber
  • Shachar Abudi
  • Aviva Eliyahu
  • Irit Tirosh
  • Shiri Shpilman
  • Shirlee Shril
  • Friedhelm Hildebrandt
  • Mordechai Shohat
  • Yair Anikster
  • BMC Med. Genet..2019 03;20(1):53. 10.1186/s12881-019-0787-x. doi: 10.1186/s12881-019-0787-x.Epub 2019-03-29.

Intrigue.イマチニブ後の進行性消化管間質腫瘍を対象としたリプレチニブ対スニチニブの第III相試験

Intrigue: Phase III study of ripretinib versus sunitinib in advanced gastrointestinal stromal tumor after imatinib.
  • John Nemunaitis
  • Sebastian Bauer
  • Jean-Yves Blay
  • Khalil Choucair
  • Hans Gelderblom
  • Suzanne George
  • Patrick Schöffski
  • Margaret von Mehren
  • John Zalcberg
  • Haroun Achour
  • Rodrigo Ruiz-Soto
  • Michael C Heinrich
  • Future Oncol.2020 Jan;16(1):4251-4264. doi: 10.2217/fon-2019-0633.Epub 2019-11-22.

ターンオーバー、ミネラル化、体積分類の潜在的バイオマーカー。血液透析患者におけるNMRメタボロミクスを用いた結果．

Potential Biomarkers of the Turnover, Mineralization, and Volume Classification: Results Using NMR Metabolomics in Hemodialysis Patients.
  • Aline L Baptista
  • Kallyandra Padilha
  • Pamella A Malagrino
  • Gabriela Venturini
  • Ana Cm Zeri
  • Luciene M Dos Reis
  • Janaina S Martins
  • Vanda Jorgetti
  • Alexandre C Pereira
  • Silvia M Titan
  • Rosa Ma Moyses
  • JBMR Plus.2020 Jul;4(7):e10372. JBM410372. doi: 10.1002/jbm4.10372.Epub 2020-05-27.

重複する臨床病理学的特徴を有する赤色染料による遅延性タトゥー反応。高周波超音波および線間光干渉断層撮影による検査

Delayed Tattoo Reaction From Red Dye With Overlapping Clinicopathological Features: Examination With High-Frequency Ultrasound and Line-Field Optical Coherence Tomography.
  • Linda Tognetti
  • Sean Ekinde
  • Cyril Habougit
  • Elisa Cinotti
  • Pietro Rubegni
  • Jean Luc Perrot
  • Dermatol Pract Concept.2020 Jul;10(3):e2020053. dp1003a53. doi: 10.5826/dpc.1003a53.Epub 2020-06-29.

健康活動プログラムの効果の持続性と費用対効果：プライマリケアでのカウンセラーによるうつ病の短期心理治療：無作為化比較試験の12ヶ月間の追跡調査

Sustained effectiveness and cost-effectiveness of the Healthy Activity Programme, a brief psychological treatment for depression delivered by lay counsellors in primary care: 12-month follow-up of a randomised controlled trial.
  • Benedict Weobong
  • Helen A Weiss
  • David McDaid
  • Daisy R Singla
  • Steven D Hollon
  • Abhijit Nadkarni
  • A-La Park
  • Bhargav Bhat
  • Basavraj Katti
  • Arpita Anand
  • Sona Dimidjian
  • Ricardo Araya
  • Michael King
  • Lakshmi Vijayakumar
  • G Terence Wilson
  • Richard Velleman
  • Betty R Kirkwood
  • Christopher G Fairburn
  • Vikram Patel
  • PLoS Med..2017 Sep;14(9):e1002385. PMEDICINE-D-17-01349. doi: 10.1371/journal.pmed.1002385.Epub 2017-09-12.

ニンジン(Daucus carota)における2つのζ-カロテンデサチュラーゼパラログの役割の違い。ZDS1 は、植物の発生とカロテノイド合成に不可欠な機能性遺伝子です

Differential role of the two ζ-carotene desaturase paralogs in carrot (Daucus carota): ZDS1 is a functional gene essential for plant development and carotenoid synthesis.
  • Carlos Flores-Ortiz
  • Lilia M Alvarez
  • Alejandro Undurraga
  • Daniela Arias
  • Felipe Durán
  • Guillermo Wegener
  • Claudia Stange
  • Plant Sci..2020 Feb;291:110327. S0168-9452(19)31500-6. doi: 10.1016/j.plantsci.2019.110327.Epub 2019-11-26.

角膜内皮再生のための生分解性および生体適合性のあるポリエチレングリコールベースのハイドロゲルフィルム

Biodegradable and biocompatible poly(ethylene glycol)-based hydrogel films for the regeneration of corneal endothelium.
  • Berkay Ozcelik
  • Karl D Brown
  • Anton Blencowe
  • Katharina Ladewig
  • Geoffrey W Stevens
  • Jean-Pierre Y Scheerlinck
  • Keren Abberton
  • Mark Daniell
  • Greg G Qiao
  • Adv Healthc Mater.2014 Sep;3(9):1496-507. doi: 10.1002/adhm.201400045.Epub 2014-03-20.

アルジェリアの中央草原Djelfaにおける子羊におけるジアルジア・デュオデナリスの発生と分子特性

Occurrence and molecular characterization of Giardia duodenalis in lambs in Djelfa, the central steppe of Algeria.
  • Soumaya Benhassine
  • Djamel Baroudi
  • Ahcene Hakem
  • Myriam Thomas
  • AbdElkarim Laatamna
  • Salem Belkessa
  • Yaoyu Feng
  • Dawn Roellig
  • Xiaohua Chen
  • Karim Tarik Adjou
  • Lihua Xiao
  • Parasitol. Res..2020 Jul;10.1007/s00436-020-06808-y. doi: 10.1007/s00436-020-06808-y.Epub 2020-07-14.

無精子症ドナーからの精液血漿中のプロタミンの定量を調査した研究。閉塞性無精子症の診断、精巣精子採取（TESE）や人工授精精子注入（ICSI）のための出産精子の採取に向けた新たな方法の提案

The study investigating the determination of protamine in seminal plasma from azoospermic donors: Suggestion of new methods to diagnose obstructive azoospermia, and to capture childbearing sperm for testicular sperm extraction (TESE) and insemination sperm injection (ICSI).
  • Masatoki Katayama
  • Satoru Kaneko
  • Takahiro Tsukimura
  • Kiyoshi Takamatsu
  • Tadayasu Togawa
  • Anal. Biochem..2020 Jul;604:113792. S0003-2697(20)30324-9. doi: 10.1016/j.ab.2020.113792.Epub 2020-07-02.

Tie2の活性化は、ヒトのセプシスにおける内皮グリコカリックスの保護と再構成を促進する

Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis.
  • Carolin Christina Drost
  • Alexandros Rovas
  • Kristina Kusche-Vihrog
  • Paul Van Slyke
  • Harold Kim
  • Van C Hoang
  • Jason T Maynes
  • Dirk Oliver Wennmann
  • Hermann Pavenstädt
  • Wolfgang Linke
  • Alexander Lukasz
  • Bettina Hesse
  • Philipp Kümpers
  • Thromb. Haemost..2019 Nov;119(11):1827-1838. doi: 10.1055/s-0039-1695768.Epub 2019-09-07.

前立腺閉塞の二次的な下部尿路症状に対する前立腺のバイポーラ対モノポーラ経尿道的切除。コクランレビュー

Bipolar vs. monopolar transurethral resection of the prostate for lower urinary tract symptoms secondary to benign prostatic obstruction: A Cochrane review.
  • Cameron Edwin Alexander
  • Malo M F Scullion
  • Muhammad Imran Omar
  • Yuhong Yuan
  • Charalampos Mamoulakis
  • James M O N'Dow
  • Changhao Chen
  • Thomas B L Lam
  • Can Urol Assoc J.2020 Jun;cuaj.6464. doi: 10.5489/cuaj.6464.Epub 2020-06-16.

3D-QSAR、分子ドッキング、分子動力学シミュレーションを用いて、新規な(5-イミダゾール-2-イル-4-フェニルピリミジン-2-イル)2-(2-ピリジルアミノ)エチルアミン誘導体のグリコーゲン合成キナーゼ3阻害剤としてのインシリコデザインを行った

In silico design novel (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine derivatives as inhibitors for glycogen synthase kinase 3 based on 3D-QSAR, molecular docking and molecular dynamics simulation.
  • Qingxiu He
  • Chu Han
  • Guangping Li
  • Haiqiong Guo
  • Yuxuan Wang
  • Yong Hu
  • Zhihua Lin
  • Yuanqiang Wang
  • Comput Biol Chem.2020 Jul;88:107328. S1476-9271(20)30643-5. doi: 10.1016/j.compbiolchem.2020.107328.Epub 2020-07-04.

UAE1 阻害は膵臓癌におけるアンフォールドタンパク応答、DNA 損傷、カスパーゼ依存性細胞死を媒介する

UAE1 inhibition mediates the unfolded protein response, DNA damage and caspase-dependent cell death in pancreatic cancer.
  • Yajing Liu
  • Sahezeel Awadia
  • Amy Delaney
  • Merna Sitto
  • Carl Engelke
  • Heli Patel
  • Andrew Calcaterra
  • Sylvia Zelenka-Wang
  • Hojin Lee
  • Joseph Contessa
  • Nouri Neamati
  • Mats Ljungman
  • Theodore S Lawrence
  • Meredith A Morgan
  • Alnawaz Rehemtulla
  • Transl Oncol.2020 Jul;13(11):100834. S1936-5233(20)30326-0. doi: 10.1016/j.tranon.2020.100834.Epub 2020-07-17.

放射線科での偶発的なCOVID-19。乳がんのCT病期分類を受けた無症候性患者におけるCOVID-19の放射線所見

Incidental COVID-19 in the radiology department: Radiographic findings of COVID-19 in asymptomatic patient undergoing CT staging for breast cancer.
  • Kevin Yoo
  • Robert Y Choi
  • Justin Sun
  • Clinton Veselis
  • Bhishak Kamat
  • Maruti Kumaran
  • Omar Agosto
  • Hillel S Maresky
  • Radiol Case Rep.2020 Sep;15(9):1614-1617. S1930-0433(20)30274-0. doi: 10.1016/j.radcr.2020.05.080.Epub 2020-06-11.

健康なボランティアを対象としたAZD5718の第1相薬物動態試験。ロスバスタチンとの併用投与、製剤および食品の経口バイオアベイラビリティーへの影響

Phase 1 Pharmacokinetic Study of AZD5718 in Healthy Volunteers: Effects of Coadministration With Rosuvastatin, Formulation and Food on Oral Bioavailability.
  • Hans Ericsson
  • Karin Nelander
  • Maria Heijer
  • Magnus Kjaer
  • Eva-Lotte Lindstedt
  • Muna Albayaty
  • Pablo Forte
  • Maria Lagerström-Fermér
  • Stanko Skrtic
  • Clin Pharmacol Drug Dev.2020 Apr;9(3):411-421. doi: 10.1002/cpdd.756.Epub 2019-12-02.

同じ一次切除標本によく分化した甲状腺がんと退形成性甲状腺がんが共存していること：13例の連続したシリーズにおける2つの成分の免疫フェノタイプおよび遺伝学的比較、および文献のレビュー

Coexisting well-differentiated and anaplastic thyroid carcinoma in the same primary resection specimen: immunophenotypic and genetic comparison of the two components in a consecutive series of 13 cases and a review of the literature.
  • Moira Ragazzi
  • Federica Torricelli
  • Benedetta Donati
  • Alessia Ciarrocchi
  • Dario de Biase
  • Giovanni Tallini
  • Eleonora Zanetti
  • Alessandra Bisagni
  • Elisabetta Kuhn
  • Davide Giordano
  • Andrea Frasoldati
  • Simonetta Piana
  • Virchows Arch..2020 Jul;10.1007/s00428-020-02891-9. doi: 10.1007/s00428-020-02891-9.Epub 2020-07-18.

東南アジアにおけるマラリア予防のためのナフトキン-アジスロマイシン共剤の有効性と安全性。第 3 相、二重盲検、無作為化、プラセボ対照試験

Efficacy and Safety of a Naphthoquine-Azithromycin Co-Formulation for Malaria Prophylaxis in Southeast Asia: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial.
  • Henglin Yang
  • Jingyan Wang
  • Hui Liu
  • Yan Zhao
  • Seetha Lakshmi
  • Xingliang Li
  • Renhua Nie
  • Chunfu Li
  • Hengye Wang
  • Yaming Cao
  • Lynette Menezes
  • Liwang Cui
  • Clin. Infect. Dis..2020 Jul;ciaa1018. doi: 10.1093/cid/ciaa1018.Epub 2020-07-20.

職人的・小規模な金採掘（ASGM）活動の影響を受けた土壌における銅、鉛、亜鉛、ヒ素の固相分離と放出保持メカニズム

Solid-phase partitioning and release-retention mechanisms of copper, lead, zinc and arsenic in soils impacted by artisanal and small-scale gold mining (ASGM) activities.
  • Carlito Baltazar Tabelin
  • Marthias Silwamba
  • Florifern C Paglinawan
  • Alissa Jane S Mondejar
  • Ho Gia Duc
  • Vannie Joy Resabal
  • Einstine M Opiso
  • Toshifumi Igarashi
  • Shingo Tomiyama
  • Mayumi Ito
  • Naoki Hiroyoshi
  • Mylah Villacorte-Tabelin
  • Chemosphere.2020 Jul;260:127574. S0045-6535(20)31769-0. doi: 10.1016/j.chemosphere.2020.127574.Epub 2020-07-10.

ミグラスタットによる治療を受けた成人ニーマン・ピック病C型患者における嚥下障害と嚥下機能の縦断的変化の特徴付け

Characterization of Dysphagia and Longitudinal Changes in Swallowing Function in Adults with Niemann-Pick Disease Type C Treated with Miglustat.
  • Courtney Lewis
  • Megan Keage
  • Miyuki Watanabe
  • Danielle Schubiger
  • Dennis Velakoulis
  • Mark Walterfang
  • Adam P Vogel
  • Dysphagia.2020 Jun;10.1007/s00455-020-10145-8. doi: 10.1007/s00455-020-10145-8.Epub 2020-06-19.

インドのプライマリケアにおける重度のうつ病に対するカウンセラーによる短時間の心理的治療であるヘルシーアクティビティプログラム（HAP）：無作為化比較試験

The Healthy Activity Program (HAP), a lay counsellor-delivered brief psychological treatment for severe depression, in primary care in India: a randomised controlled trial.
  • Vikram Patel
  • Benedict Weobong
  • Helen A Weiss
  • Arpita Anand
  • Bhargav Bhat
  • Basavraj Katti
  • Sona Dimidjian
  • Ricardo Araya
  • Steve D Hollon
  • Michael King
  • Lakshmi Vijayakumar
  • A-La Park
  • David McDaid
  • Terry Wilson
  • Richard Velleman
  • Betty R Kirkwood
  • Christopher G Fairburn
  • Lancet.2017 01;389(10065):176-185. S0140-6736(16)31589-6. doi: 10.1016/S0140-6736(16)31589-6.Epub 2016-12-15.

YBX1はp110βを標的とすることでオートファジーを仲介し、NSCLCにおけるシスプラチン感受性を低下させています

YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC.
  • Yanwei Cui
  • Fengzhou Li
  • Qiang Xie
  • Shilei Zhao
  • Tao Guo
  • Ping Guo
  • Sheng Hu
  • Jiaojiao Hao
  • Chunfang Tian
  • Wendan Yu
  • Zhuoshi Li
  • Lei Fang
  • Lei Zhao
  • Manyu Chen
  • Taihua Wu
  • Chundong Gu
  • Cell Death Dis.2020 Jun;11(6):476. 10.1038/s41419-020-2555-4. doi: 10.1038/s41419-020-2555-4.Epub 2020-06-19.

リン酸化プロテオーム解析により、CLK1 が胃癌の新規治療標的であることが明らかになった

Phosphoproteomic analysis identifies CLK1 as a novel therapeutic target in gastric cancer.
  • Niraj Babu
  • Sneha M Pinto
  • Manjusha Biswas
  • Tejaswini Subbannayya
  • Manoj Rajappa
  • Sonali V Mohan
  • Jayshree Advani
  • Pavithra Rajagopalan
  • Gajanan Sathe
  • Nazia Syed
  • Vinod D Radhakrishna
  • Oliyarasi Muthusamy
  • Sanjay Navani
  • Rekha V Kumar
  • Gopal Gopisetty
  • Thangarajan Rajkumar
  • Padhma Radhakrishnan
  • Saravanan Thiyagarajan
  • Akhilesh Pandey
  • Harsha Gowda
  • Pradip Majumder
  • Aditi Chatterjee
  • Gastric Cancer.2020 Apr;10.1007/s10120-020-01062-8. doi: 10.1007/s10120-020-01062-8.Epub 2020-04-24.

気管支肺胞液中の単純ヘルペスウイルス 1 型患者の機械換気患者の転帰に及ぼす抗ウイルス療法の効果：レトロスペクティブコホート研究

Effect of antiviral therapy on the outcome of mechanically ventilated patients with herpes simplex virus type 1 in bronchoalveolar lavage fluid: a retrospective cohort study.
  • Elisabeth Heimes
  • Michael Baier
  • Christina Forstner
  • Sebastian Weis
  • Michael Bauer
  • Michael Fritzenwanger
  • André Scherag
  • Mathias W Pletz
  • Miriam Kesselmeier
  • Stefan Hagel
  • Chest.2020 Jul;S0012-3692(20)31854-7. doi: 10.1016/j.chest.2020.06.056.Epub 2020-07-03.

チモロールマレイン酸塩を担持した第四級キトサン系感熱性ハイドロゲルの合成と特性：緑内障治療のための透明な外用眼球送達システム

Synthesis and characterization of timolol maleate-loaded quaternized chitosan-based thermosensitive hydrogel: A transparent topical ocular delivery system for the treatment of glaucoma.
  • Yousef Pakzad
  • Marziyeh Fathi
  • Yadollah Omidi
  • Masoud Mozafari
  • Ali Zamanian
  • Int. J. Biol. Macromol..2020 May;159:117-128. S0141-8130(20)33145-7. doi: 10.1016/j.ijbiomac.2020.04.274.Epub 2020-05-05.

DUODENAL-JEJUNAL BYPASSが視床下部肥満ラットの褐色付着部における脂質蓄積を減少させることを明らかにした

DUODENAL-JEJUNAL BYPASS REDUCES LIPID ACCUMULATION IN THE BROWN ADIPOSE TISSUE OF HYPOTHALAMIC OBESE RATS.
  • Vanessa Marieli Ceglarek
  • Zoé Maria Guareschi
  • Gabriela Moreira-Soares
  • Rafaela Cristiane Ecker-Passarello
  • Sandra Lucinei Balbo
  • Maria Lúcia Bonfleur
  • Sabrina Grassiolli
  • Arq Bras Cir Dig.2020 Jul;33(1):e1497. S0102-67202020000100307. doi: 10.1590/0102-672020190001e1497.

α-シヌクレイン神経毒性のリピドミクス解析によりステアロイルCoAデサチュラーゼをパーキンソン治療の標的として同定

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
  • Saranna Fanning
  • Aftabul Haque
  • Thibaut Imberdis
  • Valeriya Baru
  • M Inmaculada Barrasa
  • Silke Nuber
  • Daniel Termine
  • Nagendran Ramalingam
  • Gary P H Ho
  • Tallie Noble
  • Jackson Sandoe
  • Yali Lou
  • Dirk Landgraf
  • Yelena Freyzon
  • Gregory Newby
  • Frank Soldner
  • Elizabeth Terry-Kantor
  • Tae-Eun Kim
  • Harald F Hofbauer
  • Michel Becuwe
  • Rudolf Jaenisch
  • David Pincus
  • Clary B Clish
  • Tobias C Walther
  • Robert V Farese
  • Supriya Srinivasan
  • Michael A Welte
  • Sepp D Kohlwein
  • Ulf Dettmer
  • Susan Lindquist
  • Dennis Selkoe
  • Mol. Cell.2019 03;73(5):1001-1014.e8. S1097-2765(18)30998-5. doi: 10.1016/j.molcel.2018.11.028.Epub 2018-12-04.

完全磁気浮上式の小型遠心式左室補助装置の脈動運転下での血行動態性能。脈動運転下での完全磁気浮上式小型遠心式左室補助装置の血行動態性能：in vitro試験

Hemodynamic performance of a compact centrifugal left ventricular assist device with fully magnetic levitation under pulsatile operation: An in vitro study.
  • Tingting Wu
  • Hao Lin
  • Yuxin Zhu
  • Penghui Huang
  • Frank Lin
  • Chen Chen
  • Po-Lin Hsu
  • Proc Inst Mech Eng H.2020 Jul;:954411920937919. doi: 10.1177/0954411920937919.Epub 2020-07-10.

均一な粒子径とユニークな輸送タンパク質関連タンパク質コロナを持つFe/Mg修飾炭酸アパタイトは、乳がん細胞にドキソルビシンを効率的に送達する

Fe/Mg-Modified Carbonate Apatite with Uniform Particle Size and Unique Transport Protein-Related Protein Corona Efficiently Delivers Doxorubicin into Breast Cancer Cells.
  • Sheikh Tanzina Haque
  • Md Emranul Karim
  • Syafiq Asnawi Zainal Abidin
  • Iekhsan Othman
  • Mark M Banaszak Holl
  • Ezharul Hoque Chowdhury
  • Nanomaterials (Basel).2020 Apr;10(5). E834. doi: 10.3390/nano10050834.Epub 2020-04-27.

間葉系幹細胞由来の生体適合性膜ベシクルは、ヒト単核球の活性化と増殖を抑制する免疫調節活性を示す

Mesenchymal Stem Cell Derived Biocompatible Membrane Vesicles Demonstrate Immunomodulatory Activity Inhibiting Activation and proliferation of Human Mononuclear Cells.
  • Marina O Gomzikova
  • Sevindzh K Kletukhina
  • Sirina V Kurbangaleeva
  • Olga A Neustroeva
  • Olga S Vasileva
  • Ekaterina E Garanina
  • Svetlana F Khaiboullina
  • Albert A Rizvanov
  • Pharmaceutics.2020 Jun;12(6). E577. doi: 10.3390/pharmaceutics12060577.Epub 2020-06-23.

COVID-19患者に対する回復期血漿または高免疫性免疫グロブリン：生きたシステマティックレビュー

Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review.
  • Vanessa Piechotta
  • Khai Li Chai
  • Sarah J Valk
  • Carolyn Doree
  • Ina Monsef
  • Erica M Wood
  • Abigail Lamikanra
  • Catherine Kimber
  • Zoe McQuilten
  • Cynthia So-Osman
  • Lise J Estcourt
  • Nicole Skoetz
  • Cochrane Database Syst Rev.2020 07;7:CD013600. doi: 10.1002/14651858.CD013600.pub2.Epub 2020-07-10.

クルクミンによるGSK-3β阻害は、ヒト神経芽腫細胞において、TFEBの活性化と抗酸化活性を介してアミロイド生成を抑制します

GSK-3β inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative Activity in human neuroblastoma cells.
  • Hyun-Chul Song
  • Yubing Chen
  • Yingqing Chen
  • Jeongmin Park
  • Min Zheng
  • Young-Joon Surh
  • Uh-Hyun Kim
  • Jeong Woo Park
  • Rina Yu
  • Hun Taeg Chung
  • Yeonsoo Joe
  • Free Radic. Res..2020 Jul;:1-39. doi: 10.1080/10715762.2020.1791843.Epub 2020-07-06.

慢性HBV感染症患者におけるB型肝炎表面抗原のウイルス特異的およびグローバルT細胞に対する効果

Effects of Hepatitis B Surface Antigen on Virus-specific and Global T Cells in Patients With Chronic HBV infection.
  • Nina Le Bert
  • Upkar S Gill
  • Michelle Hong
  • Kamini Kunasegaran
  • Damien Z M Tan
  • Raidah Ahmad
  • Yang Cheng
  • Charles-A Dutertre
  • Andreas Heinecke
  • Laura Rivino
  • Anthony Tan
  • Navjyot K Hansi
  • Min Zhang
  • Sujuan Xi
  • Yutian Chong
  • Stefan Pflanz
  • Evan W Newell
  • Patrick T F Kennedy
  • Antonio Bertoletti
  • Gastroenterology.2020 Apr;S0016-5085(20)30492-3. doi: 10.1053/j.gastro.2020.04.019.Epub 2020-04-14.

非骨髄芽腫性β-サラサラ血症マウスにおけるβ-サラサラ血症患者由来の遺伝的に補正されたiPSCの安全性と有効性

The safety and effectiveness of genetically corrected iPSCs derived from β-thalassaemia patients in nonmyeloablative β-thalassaemic mice.
  • Yexing Xian
  • Yingjun Xie
  • Bing Song
  • Zhanhui Ou
  • Shuming Ouyang
  • Yuhuan Xie
  • Yi Yang
  • Zeyu Xiong
  • Haoxian Li
  • Xiaofang Sun
  • Stem Cell Res Ther.2020 Jul;11(1):288. 10.1186/s13287-020-01765-w. doi: 10.1186/s13287-020-01765-w.Epub 2020-07-16.

脳微小透析研究のためのバイオマトリックス中の物理化学的特性と未結合画分に基づく中枢神経系薬剤候補の除外

Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations.
  • Qianwen Wang
  • Tianjing Ren
  • Jiajia Zhao
  • Chun-Ho Wong
  • H Y Edwin Chan
  • Zhong Zuo
  • J Pharm Biomed Anal.2020 Jan;178:112946. S0731-7085(19)30281-X. doi: 10.1016/j.jpba.2019.112946.Epub 2019-10-25.

Brachiaria brizanthaへのEnterolobium cyclocarpumポッドおよびGliricidia sepium飼料の添加が乾物分解、揮発性脂肪酸濃度、およびin vitroメタン生産に及ぼす影響

Effect of the addition of Enterolobium cyclocarpum pods and Gliricidia sepium forage to Brachiaria brizantha on dry matter degradation, volatile fatty acid concentration, and in vitro methane production.
  • Isabel Cristina Molina-Botero
  • Johanna Mazabel
  • Jeyder Arceo-Castillo
  • José Luis Urrea-Benítez
  • Leticia Olivera-Castillo
  • Rolando Barahona-Rosales
  • Ngonidzashe Chirinda
  • Juan Ku-Vera
  • Jacobo Arango
  • Trop Anim Health Prod.2020 Jul;10.1007/s11250-020-02324-4. doi: 10.1007/s11250-020-02324-4.Epub 2020-07-09.

TOR1AIP1-associated nuclear envelopathiesの表現型をさらに拡大した2つの新規症例

Two novel cases further expand the phenotype of TOR1AIP1-associated nuclear envelopathies.
  • Ivana Lessel
  • Mei-Jan Chen
  • Sabine Lüttgen
  • Florian Arndt
  • Sigrid Fuchs
  • Stefanie Meien
  • Holger Thiele
  • Julie R Jones
  • Brandon R Shaw
  • David K Crossman
  • Peter Nürnberg
  • Bruce R Korf
  • Christian Kubisch
  • Davor Lessel
  • Hum. Genet..2020 Apr;139(4):483-498. 10.1007/s00439-019-02105-6. doi: 10.1007/s00439-019-02105-6.Epub 2020-02-13.

リトアニアの IPV ワクチン接種児を対象とした 1 価経口 2 型サビンポリオワクチン接種後の免疫原性と安全性に関する無作為化第 4 相試験

A randomized phase 4 study of immunogenicity and safety following monovalent oral type 2 Sabin polio vaccine challenge in IPV-vaccinated children in Lithuania.
  • Ananda S Bandyopadhyay
  • Chris Gast
  • Elizabeth B Brickley
  • Ricardo Rüttimann
  • Ralf Clemens
  • M Steven Oberste
  • William C Weldon
  • Margaret E Ackerman
  • Ruth I Connor
  • Wendy F Wieland-Alter
  • Peter Wright
  • Vytautas Usonis
  • J. Infect. Dis..2020 Jul;jiaa390. doi: 10.1093/infdis/jiaa390.Epub 2020-07-04.

根管形成における交渉、グライドパス、プレフレアの手順が根管形成に与える影響-用語、基本概念、および系統的なレビュー

Influence of Negotiation, Glide Path, and Preflaring Procedures on Root Canal Shaping-Terminology, Basic Concepts, and a Systematic Review.
  • Gianluca Plotino
  • Venkateshbabu Nagendrababu
  • Frederic Bukiet
  • Nicola M Grande
  • Sajesh K Veettil
  • Gustavo De-Deus
  • Hany Mohamed Aly Ahmed
  • J Endod.2020 Jun;46(6):707-729. S0099-2399(20)30076-5. doi: 10.1016/j.joen.2020.01.023.Epub 2020-04-22.

骨粗鬆症性椎体圧迫骨折（OVCF）患者の治療における片側と両側の経皮的弯曲術の比較：システマティックレビューとメタアナリシス

Comparison of unilateral versus bilateral percutaneous kyphoplasty for the treatment of patients with osteoporosis vertebral compression fracture (OVCF): a systematic review and meta-analysis.
  • Xing Cheng
  • Hou-Qing Long
  • Jing-Hui Xu
  • Yang-Liang Huang
  • Fo-Bao Li
  • Eur Spine J.2016 11;25(11):3439-3449. 10.1007/s00586-016-4395-6. doi: 10.1007/s00586-016-4395-6.Epub 2016-01-27.

5αリダクターゼ阻害剤の共投与は、処方されたグルココルチコイドの有害な代謝作用を悪化させる

Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids.
  • Nantia Othonos
  • Thomas Marjot
  • Conor Woods
  • Jonathan M Hazlehurst
  • Nikolaos Nikolaou
  • Riccardo Pofi
  • Sarah White
  • Ilaria Bonaventura
  • Craig Webster
  • Joanne Duffy
  • Thomas Cornfield
  • Ahmad Moolla
  • Andrea M Isidori
  • Leanne Hodson
  • Jeremy W Tomlinson
  • J. Clin. Endocrinol. Metab..2020 Jun;dgaa408. doi: 10.1210/clinem/dgaa408.Epub 2020-06-27.

ルネッサンスへの準備：COVID-19パンデミック時の乳がんの治療と、ユニバーサル・ヘルスケア・システム内での日常的な外科的ケアへの安全な再浮上のための計画

Preparing for the renaissance: treating breast cancer during the COVID-19 pandemic and planning for a safe re-emergence to routine surgical care within a universal health care system.
  • D Berger-Richardson
  • G Ko
  • N J Look Hong
  • Curr Oncol.2020 06;27(3):163-168. conc-27-163. doi: 10.3747/co.27.6699.Epub 2020-06-01.

ソニックヘッジホッグ/Gli経路転写標的であるNeogenin-1のダウンレギュレーションは、基底細胞癌の攻撃性と関連している

Downregulation of the Sonic Hedgehog/Gli pathway transcriptional target Neogenin-1 is associated with basal cell carcinoma aggressiveness.
  • Bárbara S Casas
  • Christelle Adolphe
  • Pablo Lois
  • Nelson Navarrete
  • Natalia Solís
  • Eva Bustamante
  • Patricio Gac
  • Patricio Cabané
  • Ivan Gallegos
  • Brandon J Wainwright
  • Verónica Palma
  • Oncotarget.2017 Oct;8(48):84006-84018. 21061. doi: 10.18632/oncotarget.21061.Epub 2017-09-19.

心筋虚血が疑われる安定した外来患者におけるフローサイトメトリーに基づく血小板反応性の性差

Sex differences in flow cytometry-based platelet reactivity in stable outpatients suspected of myocardial ischemia.
  • Farahnaz Waissi
  • Mirthe Dekker
  • Ingrid E M Bank
  • Suzanne J A Korporaal
  • Rolf T Urbanus
  • Gert J de Borst
  • Gerard Pasterkamp
  • Asbjorn M Scholtens
  • Diederick E Grobbee
  • Arend Mosterd
  • Dominique P V de Kleijn
  • Leo Timmers
  • Res Pract Thromb Haemost.2020 Jul;4(5):879-885. RTH212344. doi: 10.1002/rth2.12344.Epub 2020-05-15.

一般的なバイオマーカーから導き出された有効な死亡率リスクスコアを用いて、退院後に病院関連の静脈血栓塞栓症を医療患者の間で予測する

Predicting postdischarge hospital-associated venous thromboembolism among medical patients using a validated mortality risk score derived from common biomarkers.
  • Lindsey Snyder
  • Scott M Stevens
  • Masarret Fazili
  • Emily L Wilson
  • James F Lloyd
  • Benjamin D Horne
  • Joseph Bledsoe
  • Scott C Woller
  • Res Pract Thromb Haemost.2020 Jul;4(5):872-878. RTH212343. doi: 10.1002/rth2.12343.Epub 2020-05-20.

ヤギにおける家畜化遺伝子の起源

The origin of domestication genes in goats.
  • Zhuqing Zheng
  • Xihong Wang
  • Ming Li
  • Yunjia Li
  • Zhirui Yang
  • Xiaolong Wang
  • Xiangyu Pan
  • Mian Gong
  • Yu Zhang
  • Yingwei Guo
  • Yu Wang
  • Jing Liu
  • Yudong Cai
  • Qiuming Chen
  • Moses Okpeku
  • Licia Colli
  • Dawei Cai
  • Kun Wang
  • Shisheng Huang
  • Tad S Sonstegard
  • Ali Esmailizadeh
  • Wenguang Zhang
  • Tingting Zhang
  • Yangbin Xu
  • Naiyi Xu
  • Yi Yang
  • Jianlin Han
  • Lei Chen
  • Joséphine Lesur
  • Kevin G Daly
  • Daniel G Bradley
  • Rasmus Heller
  • Guojie Zhang
  • Wen Wang
  • Yulin Chen
  • Yu Jiang
  • Sci Adv.2020 May;6(21):eaaz5216. aaz5216. doi: 10.1126/sciadv.aaz5216.Epub 2020-05-20.

コネクトベースのモデルは大うつ病性障害の初期症状改善を予測できる

Connectome-based models can predict early symptom improvement in major depressive disorder.
  • Yumeng Ju
  • Corey Horien
  • Wentao Chen
  • Weilong Guo
  • Xiaowen Lu
  • Jinrong Sun
  • Qiangli Dong
  • Bangshan Liu
  • Jin Liu
  • Danfeng Yan
  • Mi Wang
  • Liang Zhang
  • Hua Guo
  • Futao Zhao
  • Yan Zhang
  • Xilin Shen
  • R Todd Constable
  • Lingjiang Li
  • J Affect Disord.2020 Aug;273:442-452. S0165-0327(20)30620-0. doi: 10.1016/j.jad.2020.04.028.Epub 2020-05-11.

抗ミューレリアンホルモンと卵胞数は、POSEIDON群3および4の患者における最初の完全卵巣刺激サイクルの累積治療成績を予測する能力に違いがある

Anti-Müllerian hormone and antral follicle count differ in their ability to predict cumulative treatment outcomes of the first complete ovarian stimulation cycle in patients from POSEIDON groups 3 and 4.
  • Luxin Liu
  • Canquan Zhou
  • J. Obstet. Gynaecol. Res..2020 Jul;doi: 10.1111/jog.14269.Epub 2020-07-19.

経皮的冠動脈インターベンションを受けた中国人急性冠症候群患者に対するチカグレラーとクロピドグレルの有効性評価をデータマイニングと機械学習による決定木アプローチで行った

Efficacy assessment of ticagrelor versus clopidogrel in Chinese patients with acute coronary syndrome undergoing percutaneous coronary intervention by data mining and machine-learning decision tree approaches.
  • Ying Xue
  • Ziheng Hu
  • Yankang Jing
  • Hongyi Wu
  • Xiaoye Li
  • Junmei Wang
  • Amy Seybert
  • Xiangqun Xie
  • Qianzhou Lv
  • J Clin Pharm Ther.2020 Jul;doi: 10.1111/jcpt.13172.Epub 2020-07-06.

アンキリンリピートドメイン（R635X）の病原性NFKB2変異体は可変抗体欠損症を引き起こす

Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency.
  • Paul Tuijnenburg
  • Hana Lango Allen
  • Godelieve J de Bree
  • Sinisa Savic
  • Machiel H Jansen
  • Claire Stockdale
  • Ilenia Simeoni
  • Ineke J M Ten Berge
  • Ester M M van Leeuwen
  • James E Thaventhiran
  • Taco W Kuijpers
  • Clin. Immunol..2019 06;203:23-27. S1521-6616(18)30590-4. doi: 10.1016/j.clim.2019.03.010.Epub 2019-04-03.

日常診療における関節リウマチインパクト（RAID）の使用；DAS28寛解とアンメット患者報告アウトカムの同定

Use of rheumatoid arthritis impact of disease (RAID) in routine care; identification of DAS28 remission and unmet patient-reported outcomes.
  • Jatin Mistry
  • Mohammed Sharif
  • Amy Prideaux
  • Catherine Smith
  • Malama Sumbwanyambe
  • Margaret Sibley
  • Lewis Carpenter
  • Melissa Sweeney
  • Patrick Kiely
  • Rheumatol Adv Pract.2020;4(2):rkaa013. rkaa013. doi: 10.1093/rap/rkaa013.Epub 2020-04-27.

循環性腫瘍細胞を有するHER2非増幅型早期乳癌（EORTC 90091-10093、BIG 1-12、Treat CTC）に対するトラスツズマブと観察の比較：無作為化第II相試験

Trastuzumab versus observation for HER2 nonamplified early breast cancer with circulating tumor cells (EORTC 90091-10093, BIG 1-12, Treat CTC): a randomized phase II trial.
  • M Ignatiadis
  • S Litière
  • F Rothe
  • S Riethdorf
  • C Proudhon
  • T Fehm
  • K Aalders
  • H Forstbauer
  • P A Fasching
  • E Brain
  • P Vuylsteke
  • E Guardiola
  • R Lorenz
  • K Pantel
  • K Tryfonidis
  • W Janni
  • M Piccart
  • C Sotiriou
  • B Rack
  • J-Y Pierga
  • Ann. Oncol..2018 08;29(8):1777-1783. S0923-7534(19)34129-8. doi: 10.1093/annonc/mdy211.

内視鏡支援下顎切除術。手術手技と手術縁のコントロール

Endoscopic-assisted maxillectomy: Operative technique and control of surgical margins.
  • Alberto Deganello
  • Marco Ferrari
  • Alberto Paderno
  • Mario Turri-Zanoni
  • Alberto Schreiber
  • Davide Mattavelli
  • Alperen Vural
  • Vittorio Rampinelli
  • Alberto Daniele Arosio
  • Alessandro Ioppi
  • Mario Cherubino
  • Paolo Castelnuovo
  • Piero Nicolai
  • Paolo Battaglia
  • Oral Oncol..2019 06;93:29-38. S1368-8375(19)30102-2. doi: 10.1016/j.oraloncology.2019.04.002.Epub 2019-04-11.

マングローブクラブGoniopsis cruentata（Brachyura, Grapsidae）のエラにおける（Na, K）-ATPase活性の生化学的特性とマグネシウムによるアロステリックな調節

Biochemical Characterization and Allosteric Modulation by Magnesium of (Na, K)-ATPase Activity in the Gills of the Red Mangrove Crab Goniopsis cruentata (Brachyura, Grapsidae).
  • Cintya M Moraes
  • Malson N Lucena
  • Daniela P Garçon
  • Marcelo R Pinto
  • Leonardo M Fabri
  • Rogério O Faleiros
  • Carlos F L Fontes
  • John C McNamara
  • Francisco A Leone
  • J. Membr. Biol..2020 Jun;253(3):229-245. 10.1007/s00232-020-00120-7. doi: 10.1007/s00232-020-00120-7.Epub 2020-05-22.

STING依存性パラクリニーは抗ミトックス治療に応答して乳房腫瘍のアポトーシスプライミングを形成する

STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment.
  • Steven Lohard
  • Nathalie Bourgeois
  • Laurent Maillet
  • Fabien Gautier
  • Aurélie Fétiveau
  • Hamza Lasla
  • Frédérique Nguyen
  • Céline Vuillier
  • Alison Dumont
  • Agnès Moreau-Aubry
  • Morgane Frapin
  • Laurent David
  • Delphine Loussouarn
  • Olivier Kerdraon
  • Mario Campone
  • Pascal Jézéquel
  • Philippe P Juin
  • Sophie Barillé-Nion
  • Nat Commun.2020 01;11(1):259. 10.1038/s41467-019-13689-y. doi: 10.1038/s41467-019-13689-y.Epub 2020-01-14.

グルココルチコイドが白血病細胞におけるBCL-Xの発現制御にASH2Lが重要な役割を果たすことを明らかにした

Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells.
  • Luciana Rocha-Viegas
  • Micaela Silbermins
  • María Florencia Ogara
  • Joaquín Miguel Pellegrini
  • Sol Yanel Nuñez
  • Verónica Edith García
  • Guillermo Pablo Vicent
  • Adali Pecci
  • Biochim Biophys Acta Gene Regul Mech.2020 01;1863(1):194475. S1874-9399(19)30112-9. doi: 10.1016/j.bbagrm.2019.194475.Epub 2019-12-20.

BRAG2aはPSD-95およびエンドフィリン3との相互作用を介して興奮性ポストシナプスにおけるmGluR依存性AMPA受容体の内部化を媒介している

BRAG2a Mediates mGluR-Dependent AMPA Receptor Internalization at Excitatory Postsynapses through the Interaction with PSD-95 and Endophilin 3.
  • Masahiro Fukaya
  • Takeyuki Sugawara
  • Yoshinobu Hara
  • Makoto Itakura
  • Masahiko Watanabe
  • Hiroyuki Sakagami
  • J. Neurosci..2020 May;40(22):4277-4296. JNEUROSCI.1645-19.2020. doi: 10.1523/JNEUROSCI.1645-19.2020.Epub 2020-04-27.

産地の農場で赤外線サーモグラフィーを使用して、輸送やマーケティングにさらされた牛（Bos Taurus）の肉質と生理的反応を予測する

Using infrared thermography on farm of origin to predict meat quality and physiological response in cattle (Bos Taurus) exposed to transport and marketing.
  • Holly Cuthbertson
  • Garth Tarr
  • Kate Loudon
  • Sabrina Lomax
  • Peter White
  • Paul McGreevy
  • Rodney Polkinghorne
  • Luciano A González
  • Meat Sci..2020 Apr;169:108173. S0309-1740(19)30265-7. doi: 10.1016/j.meatsci.2020.108173.Epub 2020-04-29.

クリティカルケアを支える学生たち-COVID-19パンデミックにおけるICUの腐敗を防ぐためのコンテンションプラン:ビョルン・イプセンスのポリオレスを現代に翻訳する

Students Supporting Critical Care - A contention plan to prevent the decompensation of ICUs in the COVID-19 pandemic:Translating Bjorn Ibsens' polio-lessons to modern times.
  • Pedro David Wendel Garcia
  • Paola Massarotto
  • Katja Auinger
  • Reto Andreas Schuepbach
  • Stephanie Klinzing
  • Crit Care.2020 05;24(1):211. 10.1186/s13054-020-02919-1. doi: 10.1186/s13054-020-02919-1.Epub 2020-05-08.

妊娠低酸素は、小胞体/酸化ストレスの増加を介して子宮動脈のCaスパークと自発的な一過性の外向き電流の妊娠誘発性アップレギュレーションを抑制する

Gestational Hypoxia Inhibits Pregnancy-Induced Upregulation of Ca Sparks and Spontaneous Transient Outward Currents in Uterine Arteries Via Heightened Endoplasmic Reticulum/Oxidative Stress.
  • Xiang-Qun Hu
  • Rui Song
  • Monica Romero
  • Chiranjib Dasgupta
  • Joseph Min
  • Daisy Hatcher
  • Daliao Xiao
  • Arlin Blood
  • Sean M Wilson
  • Lubo Zhang
  • Hypertension.2020 Jul;:HYPERTENSIONAHA12015235. doi: 10.1161/HYPERTENSIONAHA.120.15235.Epub 2020-07-20.

MCK1は、気分安定剤バルプロ酸によるイノシトール合成の阻害に必要なミオイノシトールリン酸合成酵素（MIPS）の新規調節因子である

MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition of inositol synthesis by the mood stabilizer valproate.
  • Wenxi Yu
  • Joshua Daniel
  • Dhara Mehta
  • Krishna Rao Maddipati
  • Miriam L Greenberg
  • PLoS ONE.2017;12(8):e0182534. PONE-D-17-20676. doi: 10.1371/journal.pone.0182534.Epub 2017-08-17.

CYP2C9およびCYP2C19の多型がプロゲステロン経口投与または膣内投与されたプロゲステロンの投薬、安全性および代謝に及ぼす影響」に対する編集者へのレター

Letter to the Editor in Response to "Effect of Polymorphisms in CYP2C9 and CYP2C19 on the Disposition, Safety and Metabolism of Progesterone Administrated Orally or Vaginally".
  • Aaron Lazorwitz
  • Christina L Aquilante
  • Jeanelle Sheeder
  • Stephanie Teal
  • Adv Ther.2020 02;37(2):963-964. 10.1007/s12325-019-01195-y. doi: 10.1007/s12325-019-01195-y.Epub 2019-12-24.

糖尿病網膜症ラットにおいて、miR-34αを阻害することで、HMGB1の発現を調節することで網膜細胞のアポトーシスと下流のNF-κB経路を減少させることができました

Inhibiting MiR-34α reduces retinal cell apoptosis and downstream NF-κB pathway in diabetic retinopathy rats through regulating HMGB1 expression.
  • Yibin Ma
  • Yunhong Du
  • Qian Xu
  • Huijing Bao
  • Zhonglian Liu
  • Yingchao Li
  • Wenjing Liu
  • Minerva Med..2020 Jul;S0026-4806.20.06625-2. doi: 10.23736/S0026-4806.20.06625-2.Epub 2020-07-17.

レニン-アンジオテンシン系阻害剤投与下でのレニン-アンジオテンシン-アルドステロン系に対するダパグリフロジンの効果

Effects of dapagliflozin on renin-angiotensin-aldosterone system under renin-angiotensin system inhibitor administration.
  • Masashi Isshiki
  • Ichiro Sakuma
  • Yasuaki Hayashino
  • Takashi Sumita
  • Kazuo Hara
  • Kazuhisa Takahashi
  • Ichiro Shiojima
  • Noriko Satoh-Asahara
  • Hiroji Kitazato
  • Daisuke Ito
  • Daigo Saito
  • Masako Hatano
  • Yuichi Ikegami
  • Shinichiro Iida
  • Akira Shimada
  • Mitsuhiko Noda
  • Endocr. J..2020 Jul;doi: 10.1507/endocrj.EJ20-0222.Epub 2020-07-01.

RNA崩壊因子であるCCR4は、植物サイトラブウイルスのホスホタンパク質によってハイジャックされ、ウイルスの複製を促進する

CCR4, a RNA decay factor, is hijacked by a plant cytorhabdovirus phosphoprotein to facilitate virus replication.
  • Zhen-Jia Zhang
  • Qiang Gao
  • Xiao-Dong Fang
  • Zhi-Hang Ding
  • Dong-Min Gao
  • Wen-Ya Xu
  • Qing Cao
  • Ji-Hui Qiao
  • Yi-Zhou Yang
  • Chenggui Han
  • Ying Wang
  • Xuefeng Yuan
  • Dawei Li
  • Xian-Bing Wang
  • Elife.2020 Mar;9. e53753. doi: 10.7554/eLife.53753.Epub 2020-03-24.

刻々と変化する世界の髄膜炎球菌疾患の疫学と、ワクチン接種による予防の可能性

The everchanging epidemiology of meningococcal disease worldwide and the potential for prevention through vaccination.
  • Sydel Parikh
  • Helen Campbell
  • Julie A Bettinger
  • Lee H Harrison
  • Helen S Marshall
  • Federico Martinon-Torres
  • Marco Aurelio Safadi
  • Zhujun Shao
  • Bingqing Zhu
  • Anne von Gottberg
  • Ray Borrow
  • Mary E Ramsay
  • Shamez N Ladhani
  • J. Infect..2020 Jun;S0163-4453(20)30378-9. doi: 10.1016/j.jinf.2020.05.079.Epub 2020-06-03.

COVID-19の重症度における内臓脂肪率の役割：ドイツにおける単施設横断的パイロット研究のハイライト

The role of visceral adiposity in the severity of COVID-19: highlights from a unicenter cross-sectional pilot study in Germany.
  • Antonia Petersen
  • Keno Bressem
  • Jakob Albrecht
  • Hans-Martin Thieß
  • Janis Vahldiek
  • Bernd Hamm
  • Marcus R Makowski
  • Alexandra Niehues
  • Stefan Niehues
  • Lisa C Adams
  • Metab. Clin. Exp..2020 Jul;:154317. S0026-0495(20)30181-5. doi: 10.1016/j.metabol.2020.154317.Epub 2020-07-13.

免疫関連の有害事象と免疫チェックポイント阻害薬の有効性 食品医薬品局が承認した免疫療法の適応を持つ消化器癌患者における免疫関連の有害事象と免疫チェックポイント阻害薬の有効性

Immune-Related Adverse Events and Immune Checkpoint Inhibitor Efficacy in Patients with Gastrointestinal Cancer with Food and Drug Administration-Approved Indications for Immunotherapy.
  • Satya Das
  • Kristen K Ciombor
  • Sigurdis Haraldsdottir
  • Yoanna Pumpalova
  • Ibrahim H Sahin
  • G Pineda
  • Yu Shyr
  • E P Lin
  • Chih-Yuan Hsu
  • Shih-Kai Chu
  • Laura W Goff
  • Dana B Cardin
  • Mehmet A Bilen
  • George A Fisher
  • Christina Wu
  • Jordan Berlin
  • Oncologist.2020 Jan;doi: 10.1634/theoncologist.2019-0637.Epub 2020-01-14.

イエルシニア・ペスティスにおけるバイオフィルムを媒介とした拡張表現型の進化的選択

Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment.
  • Yujun Cui
  • Boris V Schmid
  • Hanli Cao
  • Xiang Dai
  • Zongmin Du
  • W Ryan Easterday
  • Haihong Fang
  • Chenyi Guo
  • Shanqian Huang
  • Wanbing Liu
  • Zhizhen Qi
  • Yajun Song
  • Huaiyu Tian
  • Min Wang
  • Yarong Wu
  • Bing Xu
  • Chao Yang
  • Jing Yang
  • Xianwei Yang
  • Qingwen Zhang
  • Kjetill S Jakobsen
  • Yujiang Zhang
  • Nils Chr Stenseth
  • Ruifu Yang
  • Nat Commun.2020 01;11(1):281. 10.1038/s41467-019-14099-w. doi: 10.1038/s41467-019-14099-w.Epub 2020-01-15.

ニコチンアミドホスホリボシルトランスフェラーゼ（Nampt）／ニコチンアミドアデニンジヌクレオチド（NAD）軸は、カルシウムハンドリング経路を調節することで心房細動を抑制する

Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway.
  • Duo Feng
  • DongZhu Xu
  • Nobuyuki Murakoshi
  • Kazuko Tajiri
  • Rujie Qin
  • Saori Yonebayashi
  • Yuta Okabe
  • Siqi Li
  • Zixun Yuan
  • Kazutaka Aonuma
  • Masaki Ieda
  • Int J Mol Sci.2020 Jun;21(13). E4655. doi: 10.3390/ijms21134655.Epub 2020-06-30.

t-PA遺伝子のDNAメチル化は、電気けいれん療法を受けているうつ病患者から分離された様々な免疫細胞サブタイプの間で異なる

DNA Methylation of the t-PA Gene Differs Between Various Immune Cell Subtypes Isolated From Depressed Patients Receiving Electroconvulsive Therapy.
  • Nicole Moschny
  • Kirsten Jahn
  • Malek Bajbouj
  • Hannah Benedictine Maier
  • Matthias Ballmaier
  • Abdul Qayyum Khan
  • Christoph Pollak
  • Stefan Bleich
  • Helge Frieling
  • Alexandra Neyazi
  • Front Psychiatry.2020;11:571. doi: 10.3389/fpsyt.2020.00571.Epub 2020-06-19.

サイトメガロウイルス血清陽性と多発性硬化症の関連における地域差。システマティックレビューおよびメタアナリシス

Regional differences in the association of cytomegalovirus seropositivity and multiple sclerosis: A systematic review and meta-analysis.
  • Smathorn Thakolwiboon
  • Hannah Zhao-Fleming
  • Amputch Karukote
  • Pavida Pachariyanon
  • Hayley Gibler Williams
  • Mirla Avila
  • Mult Scler Relat Disord.2020 Jul;45:102393. S2211-0348(20)30468-5. doi: 10.1016/j.msard.2020.102393.Epub 2020-07-12.

リチウムイオン電池のための有望な負極材料としての2-カルボキシエチルゲルマニウムセスキオキシド

2-Carboxyethylgermanium Sesquioxide as A Promising Anode Material for Li-Ion Batteries.
  • Evgeniya A Saverina
  • Roman R Kapaev
  • Pavel V Stishenko
  • Alexey S Galushko
  • Victoriya A Balycheva
  • Valentine P Ananikov
  • Mikhail P Egorov
  • Viatcheslav V Jouikov
  • Pavel A Troshin
  • Mikhail A Syroeshkin
  • ChemSusChem.2020 Jun;13(12):3137-3146. doi: 10.1002/cssc.202000852.Epub 2020-05-26.

2種類以上の降圧薬を服用している無制御高血圧症患者を対象に、降圧薬の自己管理、血圧の自己測定、低カロリー・低ナトリウム食、身体運動からなる多因子介入の有効性。MEDICHY試験

Effectiveness of a multifactorial intervention, consisting of self-management of antihypertensive medication, self-measurement of blood pressure, hypocaloric and low sodium diet, and physical exercise, in patients with uncontrolled hypertension taking 2 or more antihypertensive drugs: The MEDICHY study.
  • Fabián Unda Villafuerte
  • Joan Llobera Cànaves
  • Patricia Lorente Montalvo
  • María Lucía Moreno Sancho
  • Bartolomé Oliver Oliver
  • Patricia Bassante Flores
  • Andreu Estela Mantolan
  • Joan Pou Bordoy
  • Tomás Rodríguez Ruiz
  • Ana Requena Hernández
  • Alfonso Leiva
  • Matíes Torrent Quetglas
  • José María Coll Benejam
  • Pilar D'Agosto Forteza
  • Fernando Rigo Carratalà
  • Medicine (Baltimore).2020 Apr;99(17):e19769. 00005792-202004240-00028. doi: 10.1097/MD.0000000000019769.

選択的LXRアゴニストDMHCAは、2型糖尿病における網膜および骨髄の機能障害を修正する

Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes.
  • Cristiano P Vieira
  • Seth D Fortmann
  • Masroor Hossain
  • Ana Leda Longhini
  • Sandra S Hammer
  • Bright Asare-Bediako
  • David K Crossman
  • Micheli S Sielski
  • Yvonne Adu-Agyeiwaah
  • Mariana Dupont
  • Jason L Floyd
  • Sergio Li Calzi
  • Todd Lydic
  • Robert S Welner
  • Gary J Blanchard
  • Julia V Busik
  • Maria B Grant
  • JCI Insight.2020 Jul;5(13). 137230. doi: 10.1172/jci.insight.137230.Epub 2020-07-09.

BPin前駆体のCuフッ素化による高モル活性F6-フルオロ-L-DOPAの合成（英文

Synthesis of high-molar-activity [F]6-fluoro-L-DOPA suitable for human use via Cu-mediated fluorination of a BPin precursor.
  • Andrew V Mossine
  • Sean S Tanzey
  • Allen F Brooks
  • Katarina J Makaravage
  • Naoko Ichiishi
  • Jason M Miller
  • Bradford D Henderson
  • Thomas Erhard
  • Christian Bruetting
  • Marc B Skaddan
  • Melanie S Sanford
  • Peter J H Scott
  • Nat Protoc.2020 05;15(5):1742-1759. 10.1038/s41596-020-0305-9. doi: 10.1038/s41596-020-0305-9.Epub 2020-04-08.

ジクロフェナクナトリウム関節内ゼラチン微小球製剤開発のための品質リスクマネジメントと品質バイデザイン

Quality Risk Management and Quality by Design for the Development of Diclofenac Sodium Intra-articular Gelatin Microspheres.
  • Alexandros Nakas
  • Athanasia M Dalatsi
  • Afroditi Kapourani
  • Konstantinos N Kontogiannopoulos
  • Andreana N Assimopoulou
  • Panagiotis Barmpalexis
  • AAPS PharmSciTech.2020 May;21(4):127. 10.1208/s12249-020-01678-0. doi: 10.1208/s12249-020-01678-0.Epub 2020-05-10.

2 段階の MACE プロセスにおける金属触媒の形状とエッチング液の組成を制御したシリコンナノワイヤの微細構造の工学。成長メカニズムの詳細な解析

Engineering the Microstructure of Silicon Nanowires by Controlling the Shape of the Metal Catalyst and Composition of the Etchant in a Two-step MACE Process: An In-depth Analysis of the Growth Mechanism.
  • T K Adhila
  • Hemaprabha Elangovan
  • Siju John
  • Kamanio Chattopdhyay
  • Harish Chandra Barshilia
  • Langmuir.2020 Jul;doi: 10.1021/acs.langmuir.0c01164.Epub 2020-07-20.

FGF19シグナル伝達活性化Srcによる肝ファルネソイドX受容体のリン酸化は、コレステロール値を維持し、動脈硬化から保護する

Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis.
  • Sangwon Byun
  • Hyunkyung Jung
  • Jinjing Chen
  • Young-Chae Kim
  • Dong-Hyun Kim
  • Bo Kong
  • Grace Guo
  • Byron Kemper
  • Jongsook Kim Kemper
  • J. Biol. Chem..2019 05;294(22):8732-8744. RA119.008360. doi: 10.1074/jbc.RA119.008360.Epub 2019-04-17.

培養におけるヒト大腸組織の分化。カルシウムが経上皮電気抵抗および組織凝集特性に及ぼす影響

Differentiation of human colon tissue in culture: Effects of calcium on trans-epithelial electrical resistance and tissue cohesive properties.
  • Shannon D McClintock
  • Durga Attili
  • Michael K Dame
  • Aliah Richter
  • Sabrina S Silvestri
  • Maliha M Berner
  • Margaret S Bohm
  • Kateryna Karpoff
  • Caroline L McCarthy
  • Jason R Spence
  • James Varani
  • Muhammad N Aslam
  • PLoS ONE.2020;15(3):e0222058. PONE-D-19-23237. doi: 10.1371/journal.pone.0222058.Epub 2020-03-05.

microRNA-195は心筋破綻時の代謝を制御しており、Sirtuin3の発現変化とミトコンドリアのタンパク質アセチル化を介している

MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation.
  • Xiaokan Zhang
  • Ruiping Ji
  • Xianghai Liao
  • Estibaliz Castillero
  • Peter J Kennel
  • Danielle L Brunjes
  • Marcus Franz
  • Sven Möbius-Winkler
  • Konstantinos Drosatos
  • Isaac George
  • Emily I Chen
  • Paolo C Colombo
  • P Christian Schulze
  • Circulation.2018 05;137(19):2052-2067. CIRCULATIONAHA.117.030486. doi: 10.1161/CIRCULATIONAHA.117.030486.Epub 2018-01-12.

全脳症型クロイツフェルト・ヤコブ病患者における白質変性の病因に関する免疫組織化学的および超構造学的証拠。奇妙なアストロサイトにおける誘導性一酸化窒素合成酵素の過剰発現

Immunohistochemical and ultrastructural evidence for the pathogenesis of white matter degeneration in patients with panencephalopathic-type Creutzfeldt-Jakob disease: Inducible nitric oxide synthase overexpression in bizarre astrocytes.
  • Hiroshi Kohama
  • Masahiro Kusunoki-Ii
  • Kiyota Kato
  • Masako Kato
  • Shinsuke Kato
  • Neuropathology.2020 Apr;doi: 10.1111/neup.12646.Epub 2020-04-01.

血漿中ロイコトリエンEを定量するための高感度液体クロマトグラフィー質量分析法を開発し、ヒトにおける内因性5-LO経路活性の薬理学的抑制を実証した

Development of a highly sensitive liquid chromatography-mass spectrometry method to quantify plasma leukotriene E and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man.
  • Lars Löfgren
  • Gun-Britt Forsberg
  • Pia Davidsson
  • Susanna Eketjäll
  • Carl Whatling
  • Prostaglandins Other Lipid Mediat..2020 May;150:106463. S1098-8823(20)30056-3. doi: 10.1016/j.prostaglandins.2020.106463.Epub 2020-05-23.

カルノシンはエピジェネティックな制御を介して転写に影響を与えることが、グリオブラストーマ細胞におけるピルビン酸デヒドロゲナーゼキナーゼ4プロモーターのヒストンアセチル化亢進によって実証された

Carnosine influences transcription via epigenetic regulation as demonstrated by enhanced histone acetylation of the pyruvate dehydrogenase kinase 4 promoter in glioblastoma cells.
  • Henry Oppermann
  • Athanasios Alvanos
  • Christiane Seidel
  • Jürgen Meixensberger
  • Frank Gaunitz
  • Amino Acids.2019 Jan;51(1):61-71. 10.1007/s00726-018-2619-2. doi: 10.1007/s00726-018-2619-2.Epub 2018-07-20.

メタンフェタミンの希釈濃度が表層水中に存在すると、魚類の行動障害、世代を超えた毒性、生態系レベルでの影響を引き起こすことが示唆された

Diluted concentrations of methamphetamine in surface water induce behavior disorder, transgenerational toxicity, and ecosystem-level consequences of fish.
  • Zhenglu Wang
  • Kang Mao
  • Wei Du
  • Min Cai
  • Zhaobin Zhang
  • Xiqing Li
  • Water Res..2020 Jul;184:116164. S0043-1354(20)30701-6. doi: 10.1016/j.watres.2020.116164.Epub 2020-07-10.

ゲルマニウム-リン二元系ナノ粒子を多孔質炭素マトリックスに埋め込んだ金属熱還元による高速・安定な大容量電池の開発

Fast and Stable Batteries with High Capacity Enabled by Germanium-Phosphorus Binary Nanoparticles Embedded in a Porous Carbon Matrix via Metallothermic Reduction.
  • Yuhua Yan
  • Jiafeng Ruan
  • Hongyi Xu
  • Ying Xu
  • Yuepeng Pang
  • Junhe Yang
  • Shiyou Zheng
  • ACS Appl Mater Interfaces.2020 May;12(19):21579-21585. doi: 10.1021/acsami.0c01978.Epub 2020-04-30.

最近禁欲した覚せい剤使用者の脳内では、トランスロケーター蛋白質結合の有意な上昇は認められなかった

No significant elevation of translocator protein binding in the brains of recently abstinent methamphetamine users.
  • Edythe D London
  • Kyoji Okita
  • Kaitlin R Kinney
  • Andrew C Dean
  • Megan N McClintick
  • Elizabeth J Rizor
  • Maritza C Johnson
  • Tarannom Mahmoudie
  • Arthur L Brody
  • Erika L Nurmi
  • Lauren C Seaman
  • Judah Farahi
  • Nathaniel Ginder
  • Mark A Mandelkern
  • Drug Alcohol Depend.2020 Jun;213:108104. S0376-8716(20)30269-6. doi: 10.1016/j.drugalcdep.2020.108104.Epub 2020-06-11.

都市部の黒人関節リウマチ患者における悪性腫瘍の有病率

Prevalence of Malignancy Among Urban Black Rheumatoid Arthritis Patients.
  • Isabel M McFarlane
  • Manjeet S Bhamra
  • Abhimnayu Amarnani
  • Su Yien Zhaz
  • Srinivas Kolla
  • Milena Rodriguez Alvarez
  • George Mo
  • Maya Srinivasan
  • Gil Hevroni
  • Talia Meisel
  • Abida Hasan
  • Marie S Baguidy
  • Michael Hadaddin
  • Adielle Melamed
  • Kristaq Koci
  • Nicholas Taklalsingh
  • Joshy Pathiparampil
  • Latoya Freeman
  • Ian Kaplan
  • Naureen Kabani
  • David J Ozeri
  • Elsie Watler
  • Mosab Frefer
  • Vytas Vaitkus
  • Keron Matthew
  • Fray Arroyo-Mercado
  • Helen Lyo
  • Aleksander Feoktistov
  • Randolph Sanchez
  • Faisal Soliman
  • Felix Reyes Valdez
  • Veena Dronamraju
  • Michael Trevisonno
  • Christon Grant
  • Guerrier Clerger
  • Kunfeng Sun
  • Khabbab Amin
  • Makeda Dawkins
  • Jason Green
  • Samir Fahmy
  • Apoorva Jayarangaiah
  • Stephen Anthony Waite
  • Aaliya Burza
  • Int J Clin Res Trials.2020;5(1). 145. doi: 10.15344/2456-8007/2020/145.Epub 2020-04-25.

バルト海の酸性硫酸塩土壌に関連する金属汚染の空間的センチネルとしてのオジロワシ（Haliaeetus albicilla）と大鵜（Phalacrocorax carbo）の巣子

White-tailed eagle (Haliaeetus albicilla) and great cormorant (Phalacrocorax carbo) nestlings as spatial sentinels of Baltic acidic sulphate soil associated metal contamination.
  • R K Vainio
  • I Eulaers
  • T Laaksonen
  • V Vasko
  • V Jormalainen
  • Sci. Total Environ..2020 May;718:137424. S0048-9697(20)30934-7. doi: 10.1016/j.scitotenv.2020.137424.Epub 2020-02-19.

放射性の^{222}Raと^{228}Raビームのクーロン励起からのラジウム原子核の八極子変形の進化

Evolution of Octupole Deformation in Radium Nuclei from Coulomb Excitation of Radioactive ^{222}Ra and ^{228}Ra Beams.
  • P A Butler
  • L P Gaffney
  • P Spagnoletti
  • K Abrahams
  • M Bowry
  • J Cederkäll
  • G de Angelis
  • H De Witte
  • P E Garrett
  • A Goldkuhle
  • C Henrich
  • A Illana
  • K Johnston
  • D T Joss
  • J M Keatings
  • N A Kelly
  • M Komorowska
  • J Konki
  • T Kröll
  • M Lozano
  • B S Nara Singh
  • D O'Donnell
  • J Ojala
  • R D Page
  • L G Pedersen
  • C Raison
  • P Reiter
  • J A Rodriguez
  • D Rosiak
  • S Rothe
  • M Scheck
  • M Seidlitz
  • T M Shneidman
  • B Siebeck
  • J Sinclair
  • J F Smith
  • M Stryjczyk
  • P Van Duppen
  • S Vinals
  • V Virtanen
  • N Warr
  • K Wrzosek-Lipska
  • M Zielińska
  • Phys. Rev. Lett..2020 Jan;124(4):042503. doi: 10.1103/PhysRevLett.124.042503.

半田園地帯や遠隔地における固体燃料燃焼の代替として、廃棄物からエネルギーを取り出すプロセスを利用した直接電気暖房の潜在的な環境上の利点

Potential environmental benefits of direct electric heating powered by waste-to-energy processes as a replacement of solid-fuel combustion in semi-rural and remote areas.
  • Luca Adami
  • Marco Schiavon
  • Elena Cristina Rada
  • Sci. Total Environ..2020 Jun;740:140078. S0048-9697(20)33598-1. doi: 10.1016/j.scitotenv.2020.140078.Epub 2020-06-09.

前脳橈側グリアにおけるリポ蛋白質受容体の欠損は、神経学的欠損と重度の発作をもたらす

Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures.
  • Ewa E Bres
  • Dina Safina
  • Julia Müller
  • Peter Bedner
  • Honghong Yang
  • Xavier Helluy
  • Olena Shchyglo
  • Stephan Jansen
  • Melanie D Mark
  • Alexander Esser
  • Christian Steinhäuser
  • Stefan Herlitze
  • Claus U Pietrzik
  • Swetlana Sirko
  • Denise Manahan-Vaughan
  • Andreas Faissner
  • Glia.2020 Jun;doi: 10.1002/glia.23869.Epub 2020-06-24.

包括的メタボローム解析による急性心筋梗塞ラットにおける Shexiang baoxin 錠剤の心保護効果の根底にあるメカニズムを探る

Exploring the mechanism underlying the cardioprotective effect of shexiang baoxin pill on acute myocardial infarction rats by comprehensive metabolomics.
  • Gaosong Wu
  • Linlin Chen
  • Yu Gu
  • Ying Hong
  • Junli Ma
  • Ningning Zheng
  • Jing Zhong
  • Ai-Jun Liu
  • Lili Sheng
  • Weidong Zhang
  • Houkai Li
  • J Ethnopharmacol.2020 Sep;259:113001. S0378-8741(19)34499-X. doi: 10.1016/j.jep.2020.113001.Epub 2020-05-25.

高い加水分解活性を有するグリコーゲン分岐酵素としてのThermotoga maritima MSB8 GH57 α-アミラーゼ AmyCの同定

Identification of Thermotoga maritima MSB8 GH57 α-amylase AmyC as a glycogen-branching enzyme with high hydrolytic activity.
  • Xuewen Zhang
  • Hans Leemhuis
  • Štefan Janeček
  • Mária Martinovičová
  • Tjaard Pijning
  • Marc J E C van der Maarel
  • Appl. Microbiol. Biotechnol..2019 Aug;103(15):6141-6151. 10.1007/s00253-019-09938-1. doi: 10.1007/s00253-019-09938-1.Epub 2019-06-13.

南エチオピアにおける妊娠第3期の身体活動レベルおよびその他の妊産婦の特徴、およびその関連性。プロスペクティブ・コホート研究

Level of physical activity and other maternal characteristics during the third trimester of pregnancy and its association with birthweight at term in South Ethiopia: A prospective cohort study.
  • Meseret Legesse
  • Jemal Haider Ali
  • Md Dilshad Manzar
  • Mohammed Salahuddin
  • Hamid Yimam Hassen
  • PLoS ONE.2020;15(7):e0236136. PONE-D-20-09704. doi: 10.1371/journal.pone.0236136.Epub 2020-07-20.

RNAポリメラーゼIII関連白血病の表現型と分子スペクトルの拡大

Expanding the phenotypic and molecular spectrum of RNA polymerase III-related leukodystrophy.
  • Stefanie Perrier
  • Laurence Gauquelin
  • Catherine Fallet-Bianco
  • Megan K Dishop
  • Mackenzie A Michell-Robinson
  • Luan T Tran
  • Kether Guerrero
  • Lama Darbelli
  • Myriam Srour
  • Kevin Petrecca
  • Deborah L Renaud
  • Michael Saito
  • Seth Cohen
  • Steffen Leiz
  • Bader Alhaddad
  • Tobias B Haack
  • Ingrid Tejera-Martin
  • Fernando I Monton
  • Norberto Rodriguez-Espinosa
  • Daniela Pohl
  • Savithri Nageswaran
  • Annette Grefe
  • Emma Glamuzina
  • Geneviève Bernard
  • Neurol Genet.2020 Jun;6(3):e425. NG2019012377. doi: 10.1212/NXG.0000000000000425.Epub 2020-05-11.

肝臓特異的Prknノックアウトマウスは、食事誘発性肝性ステアトーシスおよびインスリン抵抗性に対してより感受性が高い

Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance.
  • Lia R Edmunds
  • Bingxian Xie
  • Amanda M Mills
  • Brydie R Huckestein
  • Ramya Undamatla
  • Anjana Murali
  • Martha M Pangburn
  • James Martin
  • Ian Sipula
  • Brett A Kaufman
  • Iain Scott
  • Michael J Jurczak
  • Mol Metab.2020 Jul;:101051. S2212-8778(20)30125-3. doi: 10.1016/j.molmet.2020.101051.Epub 2020-07-09.

プロトカテキン酸は、筋萎縮性側索硬化症のhSOD1マウスモデルにおける生存期間を延長し、運動機能を改善し、グリア症を減少させ、神経筋接合部を維持する

Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis.
  • Lilia A Koza
  • Aimee N Winter
  • Jessica Holsopple
  • Angela N Baybayon-Grandgeorge
  • Claudia Pena
  • Jeffrey R Olson
  • Randall C Mazzarino
  • David Patterson
  • Daniel A Linseman
  • Nutrients.2020 Jun;12(6). E1824. doi: 10.3390/nu12061824.Epub 2020-06-18.

化学療法誘発性疼痛性末梢神経障害患者に対するセロトニン-ノルエピネフリン再取り込み阻害薬の効果。メタアナリシス

Effect of serotonin-norepinephrine reuptake inhibitors for patients with chemotherapy-induced painful peripheral neuropathy: A meta-analysis.
  • Soo Youn Song
  • Young Bok Ko
  • Hyeun Kim
  • Geon Woo Lee
  • Jung Bo Yang
  • Ha Kyun Chang
  • Sang Mi Kwak
  • Jaeyun Jung
  • Siyeo Lee
  • Sun Yeul Lee
  • Heon Jong Yoo
  • Medicine (Baltimore).2020 Jan;99(1):e18653. 00005792-202001030-00066. doi: 10.1097/MD.0000000000018653.

ORCA/LRWD1はヘテロクロマチン組織を制御することでALTテロメアにおける相同組換えを制御している

ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization.
  • Rosaline Y C Hsu
  • Yo-Chuen Lin
  • Christophe Redon
  • Qinyu Sun
  • Deepak K Singh
  • Yating Wang
  • Vasudha Aggarwal
  • Jaba Mitra
  • Abhijith Matur
  • Branden Moriarity
  • Taekjip Ha
  • Mirit I Aladjem
  • Kannanganattu V Prasanth
  • Supriya G Prasanth
  • iScience.2020 May;23(5):101038. S2589-0042(20)30222-4. doi: 10.1016/j.isci.2020.101038.Epub 2020-04-18.

脳卒中患者における上肢の痙縮と機能性の改善に対する体外衝撃波治療の有効性：システマティックレビューおよびメタアナリシス

The effectiveness of extracorporeal shock wave therapy for improving upper limb spasticity and functionality in stroke patients: a systematic review and meta-analysis.
  • Rosa Cabanas-Valdés
  • Pol Serra-Llobet
  • Pere Ramón Rodriguez-Rubio
  • Carlos López-de-Celis
  • Mercé Llauró-Fores
  • Jordi Calvo-Sanz
  • Clin Rehabil.2020 Jun;:269215520932196. doi: 10.1177/0269215520932196.Epub 2020-06-08.

転移性非小細胞肺がん患者の治療で達成された進歩は高齢者にも届くか？スイス東部のがんセンターによるコホート研究

Does progress achieved in the treatment of patients with metastatic non-small-cell lung cancer reach the elderly population? A cohort study from a cancer centre from Eastern Switzerland.
  • Sabine Schmid
  • Jorune Suipyte
  • Christian Herrmann
  • Mohsen Mousavi
  • Felicitas Hitz
  • Martin Früh
  • Eur J Cancer Care (Engl).2020 Mar;29(2):e13206. doi: 10.1111/ecc.13206.Epub 2020-01-21.

毛様体メラニン濃縮ホルモン受容体1（MCHR1）は、マウスの中枢神経系に広く分布しており、性に依存しない形で分布していることが明らかになった

Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent manner.
  • Giovanne B Diniz
  • Daniella S Battagello
  • Marianne O Klein
  • Bianca S M Bono
  • Jozélia G P Ferreira
  • Livia C Motta-Teixeira
  • Jessica C G Duarte
  • Françoise Presse
  • Jean-Louis Nahon
  • Antoine Adamantidis
  • Melissa J Chee
  • Luciane V Sita
  • Jackson C Bittencourt
  • J. Neurosci. Res..2020 Jun;doi: 10.1002/jnr.24651.Epub 2020-06-12.

マイクロスケール添加剤製造による金属。微細構造と機械的特性の比較

Metals by Micro-Scale Additive Manufacturing: Comparison of Microstructure and Mechanical Properties.
  • Alain Reiser
  • Lukas Koch
  • Kathleen A Dunn
  • Toshiki Matsuura
  • Futoshi Iwata
  • Ofer Fogel
  • Zvi Kotler
  • Nanjia Zhou
  • Kristin Charipar
  • Alberto Piqué
  • Patrik Rohner
  • Dimos Poulikakos
  • Sanghyeon Lee
  • Seung Kwon Seol
  • Ivo Utke
  • Cathelijn van Nisselroy
  • Tomaso Zambelli
  • Jeffrey M Wheeler
  • Ralph Spolenak
  • Adv Funct Mater.2020 Jul;30(28):1910491. ADFM201910491. doi: 10.1002/adfm.201910491.Epub 2020-05-25.

静脈リザーバーと真空補助静脈ドレナージレベルを変化させた新生児心肺バイパス回路におけるCapiox FX05およびRX05酸素吸入器のin vitro評価

In vitro evaluation of Capiox FX05 and RX05 oxygenators in neonatal cardiopulmonary bypass circuits with varying venous reservoir and vacuum-assisted venous drainage levels.
  • Shyama Sathianathan
  • Rafay Nasir
  • Shigang Wang
  • Allen R Kunselman
  • Akif Ündar
  • Artif Organs.2020 Jan;44(1):28-39. doi: 10.1111/aor.13404.Epub 2019-01-14.

地中海式の食事パターンは、アンドロゲン遮断療法を受けた前立腺がん男性のがん関連疲労と生活の質を改善する。パイロットランダム化対照試験

Mediterranean-style dietary pattern improves cancer-related fatigue and quality of life in men with prostate cancer treated with androgen deprivation therapy: A pilot randomised control trial.
  • Brenton J Baguley
  • Tina L Skinner
  • David G Jenkins
  • Olivia R L Wright
  • Clin Nutr.2020 May;S0261-5614(20)30250-8. doi: 10.1016/j.clnu.2020.05.016.Epub 2020-05-25.

成人喘息患者における自己申告による鼻腔内過反応の有病率と誘因

Prevalence and triggers of self-reported nasal hyperreactivity in adults with asthma.
  • Jef Feijen
  • Sven F Seys
  • Brecht Steelant
  • Dominique M A Bullens
  • Lieven J Dupont
  • Maria García-Cruz
  • Alejandro Jimenez-Chobillón
  • Désirée Larenas-Linnemann
  • Laura Van Gerven
  • Wytske J Fokkens
  • Ioana Agache
  • Peter W Hellings
  • World Allergy Organ J.2020 Jun;13(6):100132. S1939-4551(20)30035-1. doi: 10.1016/j.waojou.2020.100132.Epub 2020-07-01.

血液ソーセージに関連した侵襲性リステリア症の全国的大規模アウトブレイク、ドイツ、2018-2019年

Large Nationwide Outbreak of Invasive Listeriosis Associated with Blood Sausage, Germany, 2018-2019.
  • Sven Halbedel
  • Hendrik Wilking
  • Alexandra Holzer
  • Sylvia Kleta
  • Martin A Fischer
  • Stefanie Lüth
  • Ariane Pietzka
  • Steliana Huhulescu
  • Raskit Lachmann
  • Amrei Krings
  • Werner Ruppitsch
  • Alexandre Leclercq
  • Rolf Kamphausen
  • Maylin Meincke
  • Christiane Wagner-Wiening
  • Matthias Contzen
  • Iris Barbara Kraemer
  • Sascha Al Dahouk
  • Franz Allerberger
  • Klaus Stark
  • Antje Flieger
  • Emerging Infect. Dis..2020 Jul;26(7):1456-1464. doi: 10.3201/eid2607.200225.

超分子重合による凝集誘起発光を有する発光性超分子集合体の簡便な構築とその生物学的イメージング

Facile construction of luminescent supramolecular assemblies with aggregation-induced emission feature through supramolecular polymerization and their biological imaging.
  • Lili Guo
  • Dazhuang Xu
  • Long Huang
  • Meiying Liu
  • Hongye Huang
  • Jianwen Tian
  • Ruming Jiang
  • Yuanqing Wen
  • Xiaoyong Zhang
  • Yen Wei
  • Mater Sci Eng C Mater Biol Appl.2018 Apr;85:233-238. S0928-4931(17)32713-3. doi: 10.1016/j.msec.2017.12.031.Epub 2018-01-03.

遺伝学的手法を用いたゲノムワイドなmiRNAベースのSSRマーカーの開発とグラミネア/非グラミネアの種への移植性の解析

Genome-wide development of miRNA-based SSR markers in Cleistogenes songorica and analysis of their transferability to Gramineae/non-Gramineae species.
  • Gisele Kanzana
  • Yufei Zhang
  • Tiantian Ma
  • Wenxian Liu
  • Fan Wu
  • Qi Yan
  • Xueyang Min
  • Zhuanzhuan Yan
  • Blaise Pascal Muvunyi
  • Jie Li
  • Zhengshe Zhang
  • Yufeng Zhao
  • Jiyu Zhang
  • J. Appl. Genet..2020 Jun;10.1007/s13353-020-00561-9. doi: 10.1007/s13353-020-00561-9.Epub 2020-06-07.

3,3-ジフルオロ化テトラヒドロピリジノール化合物がCDK7を介したCdc2のリン酸化を阻害し、細胞周期停止を介して作用する肝細胞癌の新規抗腫瘍剤であることを明らかにした

Identification of a 3,3-difluorinated tetrahydropyridinol compound as a novel antitumor agent for hepatocellular carcinoma acting via cell cycle arrest through disturbing CDK7-mediated phosphorylation of Cdc2.
  • Wu Bi
  • Ji-Chang Xiao
  • Rui-Jie Liu
  • Liu-Ying Zhou
  • Sai Zhang
  • Mei Yang
  • Peng-Fei Zhang
  • Invest New Drugs.2020 04;38(2):287-298. 10.1007/s10637-019-00792-6. doi: 10.1007/s10637-019-00792-6.Epub 2019-05-11.

CRISPR/Cas9を介在させたゲノム編集マウスにより、精巣に濃縮された10個の遺伝子が男性の繁殖には不要な遺伝子であることが明らかになった

CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity.
  • Soojin Park
  • Keisuke Shimada
  • Yoshitaka Fujihara
  • Zoulan Xu
  • Kentaro Shimada
  • Tamara Larasati
  • Putri Pratiwi
  • Ryan M Matzuk
  • Darius J Devlin
  • Zhifeng Yu
  • Thomas X Garcia
  • Martin M Matzuk
  • Masahito Ikawa
  • Biol. Reprod..2020 May;ioaa084. doi: 10.1093/biolre/ioaa084.Epub 2020-05-26.

COVID-19 パンデミック時の個人用保護具の病院前での適切な使用を教える。ゲーム化されたe-ラーニングモジュールの開発

Teaching Adequate Prehospital Use of Personal Protective Equipment During the COVID-19 Pandemic: Development of a Gamified e-Learning Module.
  • Mélanie Suppan
  • Birgit Gartner
  • Eric Golay
  • Loric Stuby
  • Marion White
  • Philippe Cottet
  • Mohamed Abbas
  • Anne Iten
  • Stephan Harbarth
  • Laurent Suppan
  • JMIR Serious Games.2020 Jun;8(2):e20173. v8i2e20173. doi: 10.2196/20173.Epub 2020-06-12.

バーチャルスクリーニングとMM-GBSAレスコアリングによる選択的6-ヒドロキシ-1,4-ジアゼパン-2-オン含有ブチリルコリンエステラーゼ阻害剤の発見

Discovery of a Selective 6-Hydroxy-1, 4-Diazepan-2-one Containing Butyrylcholinesterase Inhibitor by Virtual Screening and MM-GBSA Rescoring.
  • You Zhou
  • Yanyu Hu
  • Xin Lu
  • Hongyu Yang
  • Qihang Li
  • Chenxi Du
  • Yao Chen
  • Kwon Ho Hong
  • Haopeng Sun
  • Dose Response.2020 Apr-Jun;18(2):1559325820938526. 10.1177_1559325820938526. doi: 10.1177/1559325820938526.Epub 2020-06-29.

既存の取り外し可能な部分入れ歯の下に戦略的なミニインプラントを即時または遅延的に装填した場合：多施設無作為化臨床試験における患者の満足度

Immediate versus delayed loading of strategic mini-implants under existing removable partial dentures: patient satisfaction in a multi-center randomized clinical trial.
  • Ahmad Al Jaghsi
  • Friedhelm Heinemann
  • Reiner Biffar
  • Torsten Mundt
  • Clin Oral Investig.2020 Jun;10.1007/s00784-020-03360-y. doi: 10.1007/s00784-020-03360-y.Epub 2020-06-12.

スルファメトキサゾールとテトラサイクリンは、Synechocystis sp. PCC 6803 のバイオマス、光合成、脂質生産性、およびプロテオミクス発現における変化を誘導した

Sulfamethoxazole and tetracycline induced alterations in biomass, photosynthesis, lipid productivity, and proteomic expression of Synechocystis sp. PCC 6803.
  • Mengwen Cui
  • Ying Liu
  • Jian Zhang
  • Environ Sci Pollut Res Int.2020 May;10.1007/s11356-020-09327-6. doi: 10.1007/s11356-020-09327-6.Epub 2020-05-27.

2-フェニル-5,6,7,8-テトラヒドロキノキサリン誘導体の合成とラット血管内膜の単離製剤におけるP2X1プリノレセプターアンタゴニスト活性のスクリーニング、男性避妊薬への翻訳

Synthesis of 2-phenyl-5,6,7,8-tetrahydroquinoxaline derivatives and screening for P2X1-purinoreceptor antagonist activity in isolated preparations of rat vas deferens, for translation into a male contraceptive.
  • Mitch Mathiew
  • Belinda Dennis
  • Felix Bennetts
  • Eunice Su
  • Nghi Nguyen
  • Antony Botteon
  • Jonathan Baell
  • Sabatino Ventura
  • Biol. Reprod..2020 Jul;ioaa117. doi: 10.1093/biolre/ioaa117.Epub 2020-07-10.

インスリンデグルデックを投与されている1型糖尿病患者の夜間無症候性低血糖症の発症を予測することは可能か？前日血糖値と翌朝血糖値の役割の可能性

Is it possible to predict the onset of nocturnal asymptomatic hypoglycemia in patients with type 1 diabetes receiving insulin degludec? Potential role of previous day and next morning glucose values.
  • Hiroshi Takahashi
  • Rimei Nishimura
  • J Diabetes Investig.2020 Jul;doi: 10.1111/jdi.13363.Epub 2020-07-15.

ぶどう膜黒色腫の転移性群と非転移性群におけるp52およびRelBタンパク質の発現と患者転帰の違い

Differential expression of p52 and RelB proteins in the metastatic and non-metastatic groups of uveal melanoma with patient outcome.
  • Mithalesh Kumar Singh
  • Lata Singh
  • Kunzang Chosdol
  • Neelam Pushker
  • Neeru Saini
  • Rachna Meel
  • Sameer Bakhshi
  • Seema Sen
  • Seema Kashyap
  • J. Cancer Res. Clin. Oncol..2019 Dec;145(12):2969-2982. 10.1007/s00432-019-03052-5. doi: 10.1007/s00432-019-03052-5.Epub 2019-10-14.

強力なSARS-CoV-2中和抗体の単離と小動物モデルでの病気からの保護

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.
  • Thomas F Rogers
  • Fangzhu Zhao
  • Deli Huang
  • Nathan Beutler
  • Alison Burns
  • Wan-Ting He
  • Oliver Limbo
  • Chloe Smith
  • Ge Song
  • Jordan Woehl
  • Linlin Yang
  • Robert K Abbott
  • Sean Callaghan
  • Elijah Garcia
  • Jonathan Hurtado
  • Mara Parren
  • Linghang Peng
  • Sydney Ramirez
  • James Ricketts
  • Michael J Ricciardi
  • Stephen A Rawlings
  • Nicholas C Wu
  • Meng Yuan
  • Davey M Smith
  • David Nemazee
  • John R Teijaro
  • James E Voss
  • Ian A Wilson
  • Raiees Andrabi
  • Bryan Briney
  • Elise Landais
  • Devin Sok
  • Joseph G Jardine
  • Dennis R Burton
  • Science.2020 Jun;eabc7520. doi: 10.1126/science.abc7520.Epub 2020-06-15.

4,4'-ジブロモジフェニルエーテルを含むトリトンX-100模擬洗濯廃棄物の光処理に及ぼす硝酸塩の影響.キネティクス,生成物及び毒性評価

Effect of nitrate on the phototreatment of Triton X-100 simulated washing waste containing 4,4'-dibromodiphenyl ether: Kinetics, products and toxicity assessment.
  • Kaibo Huang
  • Jiahao Liang
  • Jin Wang
  • Yuanxi Ouyang
  • Rui Wang
  • Ting Tang
  • Yusen Luo
  • Xueqin Tao
  • Hua Yin
  • Zhi Dang
  • Guining Lu
  • Sci. Total Environ..2020 Aug;732:139247. S0048-9697(20)32764-9. doi: 10.1016/j.scitotenv.2020.139247.Epub 2020-05-08.

プルラン合成を決定する真菌α-グルカン合成酵素と細胞壁α-1,3グルカン合成を制御する真菌α-1,3グルカン合成酵素の違い

The differences between fungal α-glucan synthase determining pullulan synthesis and that controlling cell wall α-1,3 glucan synthesis.
  • Cong-Yan Qi
  • Shu-Lei Jia
  • Xin Wei
  • Guang Yang
  • Zhe Chi
  • Guang-Lei Liu
  • Zhong Hu
  • Zhen-Ming Chi
  • Int. J. Biol. Macromol..2020 Jun;162:436-444. S0141-8130(20)33587-X. doi: 10.1016/j.ijbiomac.2020.06.147.Epub 2020-06-20.

花粉抗原の観点から見た日本列島における花粉調査の長期的な結果

[LONG-TERM RESULTS OF AIRBORNE POLLEN SURVEYS IN THE JAPANESE ARCHIPELAGO FROM THE PERSPECTIVE OF POLLEN ANTIGEN].
  • Reiko Kishikawa
  • Eiko Koto
  • Chie Oshikawa
  • Nobuo So
  • Terufumi Shimoda
  • Akemi Saito
  • Norio Sahashi
  • Tadao Enomoto
  • Atsushi Usami
  • Hidetoyo Teranishi
  • Yohko Fujisaki
  • Toshitaka Yokoyama
  • Kohji Murayama
  • Satoshi Honjo
  • Yuma Fukutomi
  • Tohru Imai
  • Masami Taniguchi
  • Makoto Yoshida
  • Tomoaki Iwanaga
  • Arerugi.2019;68(10):1221-1238. doi: 10.15036/arerugi.68.1221.

下顎第三大臼歯抜歯を必要とする患者における不安感と血行動態パラメータに対する情報提供ビデオの効果。無作為化臨床試験

Effect of an Informative Video on Anxiety and Hemodynamic Parameters in Patients Requiring Mandibular Third Molar Extraction: A Randomized Clinical Trial.
  • Jorge Toledano-Serrabona
  • Alba Sánchez-Torres
  • Octavi Camps-Font
  • Rui Figueiredo
  • Cosme Gay-Escoda
  • Eduard Valmaseda-Castellón
  • J. Oral Maxillofac. Surg..2020 Jun;S0278-2391(20)30667-4. doi: 10.1016/j.joms.2020.06.024.Epub 2020-06-22.

リアルタイムポリメラーゼ連鎖反応を用いたキネトプラスチジア種の人獣共通感染症の鑑別診断アルゴリズム

Real-time polymerase chain reaction based algorithm for differential diagnosis of Kinetoplastidean species of zoonotic relevance.
  • Arturo Muñoz-Calderón
  • Diana Wehrendt
  • Carolina Cura
  • Andrea Gómez-Bravo
  • Marcelo Abril
  • Matilde Giammaria
  • Raúl Horacio Lucero
  • Alejandro G Schijman
  • Infect. Genet. Evol..2020 Sep;83:104328. S1567-1348(20)30159-3. doi: 10.1016/j.meegid.2020.104328.Epub 2020-04-21.

プロバイオティクス特性を有する新規ラクトバチルス・ラムノサス菌株のリポ多糖類誘発性腸炎に対するin vitroおよびin vivoでの保護効果

Protective effects of a novel Lactobacillus rhamnosus strain with probiotic characteristics against lipopolysaccharide-induced intestinal inflammation in vitro and in vivo.
  • Xuesong Li
  • Dong Hu
  • Yazhen Tian
  • Yang Song
  • Yichao Hou
  • Linlin Sun
  • Yu Zhang
  • Chaoxin Man
  • Wei Zhang
  • Yujun Jiang
  • Food Funct.2020 Jun;doi: 10.1039/d0fo00308e.Epub 2020-06-22.

カルボシクリルヌクレオシド系抗生物質アリステロマイシンの生合成におけるミオ-イノシトールリン酸合成酵素オルソログによる五員環状リン酸形成（英文

Five-Membered Cyclitol Phosphate Formation by a myo-Inositol Phosphate Synthase Orthologue in the Biosynthesis of the Carbocyclic Nucleoside Antibiotic Aristeromycin.
  • Fumitaka Kudo
  • Takeshi Tsunoda
  • Makoto Takashima
  • Tadashi Eguchi
  • Chembiochem.2016 Nov;17(22):2143-2148. doi: 10.1002/cbic.201600348.Epub 2016-09-30.

インパクト下顎第三大臼歯手術後の術後罹患率に対するキネシオテーピングの有効性：プロスペクティブ、無作為化、プラセボ対照臨床試験

Effectiveness of kinesio taping on postoperative morbidity after impacted mandibular third molar surgery: a prospective, randomized, placebo-controlled clinical study.
  • Ufuk Tatli
  • Ilke Coskun Benlidayi
  • Fariz Salimov
  • Rengin Guzel
  • J Appl Oral Sci.2020;28:e20200159. S1678-77572020000100457. doi: 10.1590/1678-7757-2020-0159.Epub 2020-07-13.

デンタルフォレンジックキット（DFK®）とQuick Extract™ FFPE DNA抽出キットは、人間の遺伝的同一性のための歯科用DNAを取得するための新しいワークフローです

Dental Forensic Kit (DFK®) and Quick Extract™ FFPE DNA extraction kit, a new workflow for obtaining dental DNA for human genetic identity.
  • Carolina Inostroza
  • Patricio Carrasco
  • Marianela Godoy
  • Gianna Gatti
  • Beatriz Paulino
  • J Forensic Leg Med.2020 Jul;73:101992. S1752-928X(20)30099-8. doi: 10.1016/j.jflm.2020.101992.Epub 2020-06-02.

活動性難治性/再発骨髄性悪性腫瘍に対する逐次的同種造血幹細胞移植：クロファラビンとシトシンアラビノシドを用いた低強度条件付けの結果、SFGM-TCを代表して行われたレトロスペクティブな研究

Sequential allogeneic hematopoietic stem cell transplantation for active refractory/relapsed myeloid malignancies: results of a reduced-intensity conditioning preceded by clofarabine and cytosine arabinoside, a retrospective study on behalf of the SFGM-TC.
  • Amandine Le Bourgeois
  • Myriam Labopin
  • Ambroise Marçais
  • Regis Peffault de Latour
  • Didier Blaise
  • Sylvain Chantepie
  • Stéphanie N'Guyen
  • Natacha Maillard
  • Edouard Forcade
  • Ibrahim Yakoub-Agha
  • Anne Huynh
  • Tony Marchand
  • Karin Bilger
  • Patrice Ceballos
  • Amandine Charbonnier
  • Pascal Turlure
  • Marie-Thérese Rubio
  • Marie Christine Béné
  • Thierry Guillaume
  • Mohamad Mohty
  • Patrice Chevallier
  • Ann. Hematol..2020 Aug;99(8):1855-1862. 10.1007/s00277-020-04074-7. doi: 10.1007/s00277-020-04074-7.Epub 2020-06-20.

新規選択的エストロゲン受容体モジュレーターである BE360 の抗うつ効果は、CREB/BDNF, Bcl-2 シグナル経路を介して活性化され、卵巣摘出マウスの認知症治療に有効であることを報告した

Antidepressant effect of BE360, a new selective estrogen receptor modulator, activated via CREB/BDNF, Bcl-2 signaling pathways in ovariectomized mice.
  • Wakana Sakuma
  • Osamu Nakagawasai
  • Wataru Nemoto
  • Takayo Odaira
  • Takumi Ogawa
  • Kiminori Ohta
  • Yasuyuki Endo
  • Koichi Tan-No
  • Behav. Brain Res..2020 Jun;393:112764. S0166-4328(20)30463-0. doi: 10.1016/j.bbr.2020.112764.Epub 2020-06-11.

統合プロテオミクスおよびメタボロミクス解析により、温水浸漬を受けた大豆種子における相関性のある代謝物-タンパク質ネットワークが明らかになった

Integrated Proteomics and Metabolomics Analysis Highlights Correlative Metabolite-Protein Networks in Soybean Seeds Subjected to Warm-Water Soaking.
  • Cheol Woo Min
  • Hyejin Hyeon
  • Ravi Gupta
  • Joonho Park
  • Ye Eun Cheon
  • Gi Hyun Lee
  • Jeong Woo Jang
  • Hyung Won Ryu
  • Byong Won Lee
  • Sang Un Park
  • Youngsoo Kim
  • Jae Kwang Kim
  • Sun Tae Kim
  • J. Agric. Food Chem..2020 Jul;doi: 10.1021/acs.jafc.0c00986.Epub 2020-07-15.

ゲノム増幅依存性発現と機能低下スクリーニングの統合的解析により、ASAP1はトリプルネガティブ乳癌の進行におけるドライバー遺伝子であることが明らかになった

Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression.
  • Jichao He
  • Ronan P McLaughlin
  • Lambert van der Beek
  • Sander Canisius
  • Lodewyk Wessels
  • Marcel Smid
  • John W M Martens
  • John A Foekens
  • Yinghui Zhang
  • Bob van de Water
  • Oncogene.2020 May;39(20):4118-4131. 10.1038/s41388-020-1279-3. doi: 10.1038/s41388-020-1279-3.Epub 2020-03-31.

スクラロースの集中投与により誘発される低体温症は、ヒナの視床下部のモノアミン作動経路を介して発生する可能性がある

Hypothermia induced by central injection of sucralose potentially occurs via monoaminergic pathways in the hypothalamus of chicks.
  • Hatem M Eltahan
  • Linh T N Nguyen
  • Guofeng Han
  • Hui Yang
  • Mohamed N Ali
  • Khairy A Amber
  • Mitsuhiro Furuse
  • Vishwajit S Chowdhury
  • Comp. Biochem. Physiol., Part A Mol. Integr. Physiol..2020 Jul;248:110752. S1095-6433(20)30104-5. doi: 10.1016/j.cbpa.2020.110752.Epub 2020-07-04.

末梢神経の損傷と感作が口腔癌の神経周囲浸潤に伴う疼痛の根底にあることを明らかにした

Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion.
  • Elizabeth Salvo
  • Wendy M Campana
  • Nicole N Scheff
  • Nguyen Huu Tu
  • Se-Hee Jeong
  • Ian Wall
  • Angie K Wu
  • Susanna Zhang
  • Hyesung Kim
  • Aditi Bhattacharya
  • Malvin N Janal
  • Cheng Liu
  • Donna G Albertson
  • Brian L Schmidt
  • John C Dolan
  • Robert E Schmidt
  • M Danilo Boada
  • Yi Ye
  • Pain.2020 Jul;doi: 10.1097/j.pain.0000000000001986.Epub 2020-07-08.

消化管間質性腫瘍患者におけるイマチニブの治療薬モニタリング-日常臨床からの結果

Therapeutic drug monitoring of imatinib in patients with gastrointestinal stromal tumours - Results from daily clinical practice.
  • Nikki S IJzerman
  • Stefanie L Groenland
  • Anne Miek Koenen
  • Martijn Kerst
  • Winette T A van der Graaf
  • Hilde Rosing
  • Jos H Beijnen
  • Alwin D R Huitema
  • Neeltje Steeghs
  • Eur. J. Cancer.2020 Jul;136:140-148. S0959-8049(20)30297-5. doi: 10.1016/j.ejca.2020.05.025.Epub 2020-07-17.

NGAL特異的細胞の発現とmRNAレベルは、唾液腺の炎症、および原発性シェーグレン症候群患者の唾液中での過剰発現と相関している

Expression of NGAL-specific cells and mRNA levels correlate with inflammation in the salivary gland, and its overexpression in the saliva, of patients with primary Sjögren's syndrome.
  • Lara A Aqrawi
  • Janicke Liaaen Jensen
  • Siren Fromreide
  • Hilde Kanli Galtung
  • Kathrine Skarstein
  • Autoimmunity.2020 Jul;:1-11. doi: 10.1080/08916934.2020.1795140.Epub 2020-07-20.

出版社の訂正。過体重・肥満の閉経前女性の大腿部骨格筋の脂肪組織含量と首囲は関連している

Publisher Correction: Neck circumference is associated with adipose tissue content in thigh skeletal muscle in overweight and obese premenopausal women.
  • Maria Jose Arias Tellez
  • Analiza M Silva
  • Jonatan R Ruiz
  • Sandra S Martins
  • António L Palmeira
  • Teresa L Branco
  • Claudia S Minderico
  • Paulo M Rocha
  • José Themudo-Barata
  • Pedro J Teixeira
  • Luís B Sardinha
  • Sci Rep.2020 Jul;10(1):12013. 10.1038/s41598-020-69150-4. doi: 10.1038/s41598-020-69150-4.Epub 2020-07-16.

SMARCA4関連コフィン・シリス症候群の変動性。ナンセンスな候補変異体は、より軽度な表現型に付加するか？

The variability of SMARCA4-related Coffin-Siris syndrome: Do nonsense candidate variants add to milder phenotypes?
  • Dong Li
  • Rebecca C Ahrens-Nicklas
  • Janice Baker
  • Vikas Bhambhani
  • Amy Calhoun
  • Julie S Cohen
  • Matthew A Deardorff
  • Alberto Fernández-Jaén
  • Benjamin Kamien
  • Mahim Jain
  • Fiona Mckenzie
  • Mark Mintz
  • Constance Motter
  • Kirsten Niles
  • Alyssa Ritter
  • Curtis Rogers
  • Maian Roifman
  • Sharron Townshend
  • Catherine Ward-Melver
  • Samantha A Schrier Vergano
  • Am. J. Med. Genet. A.2020 Jul;doi: 10.1002/ajmg.a.61732.Epub 2020-07-20.

MerTKの阻害は、グリオブラストーマ微小環境における免疫抑制性のグリオブラストーマ関連マクロファージと新生血管新生を減少させる

MerTK inhibition decreases immune suppressive glioblastoma-associated macrophages and neoangiogenesis in glioblastoma microenvironment.
  • Yu-Ting Su
  • Madison Butler
  • Meili Zhang
  • Wei Zhang
  • Hua Song
  • Lee Hwang
  • Andy D Tran
  • Ryan E Bash
  • Allison N Schorzman
  • Ying Pang
  • Guangyang Yu
  • William C Zamboni
  • Xiaodong Wang
  • Stephen V Frye
  • Christopher Ryan Miller
  • Dragan Maric
  • Masaki Terabe
  • Mark R Gilbert
  • Henry Shelton Earp Iii
  • Jing Wu
  • Neurooncol Adv.2020 Jan-Dec;2(1):vdaa065. vdaa065. doi: 10.1093/noajnl/vdaa065.Epub 2020-06-03.

非球面上腕骨頭とインレーグレノイド置換術による肩関節全置換術：原発性肩関節症における同心グレノイドと非同心グレノイドのステージを比較した臨床結果

Total shoulder arthroplasty with nonspherical humeral head and inlay glenoid replacement: clinical results comparing concentric and nonconcentric glenoid stages in primary shoulder arthritis.
  • Anthony C Egger
  • Jennifer Peterson
  • Morgan H Jones
  • Anthony Miniaci
  • JSES Open Access.2019 Oct;3(3):145-153. S2468-6026(19)30030-0. doi: 10.1016/j.jses.2019.07.009.Epub 2019-09-13.

機械学習を用いて、有料サービスのメディケア受給者におけるオピオイド使用障害の発生リスクを予測する。予後予測研究

Using machine learning to predict risk of incident opioid use disorder among fee-for-service Medicare beneficiaries: A prognostic study.
  • Wei-Hsuan Lo-Ciganic
  • James L Huang
  • Hao H Zhang
  • Jeremy C Weiss
  • C Kent Kwoh
  • Julie M Donohue
  • Adam J Gordon
  • Gerald Cochran
  • Daniel C Malone
  • Courtney C Kuza
  • Walid F Gellad
  • PLoS ONE.2020;15(7):e0235981. PONE-D-20-09504. doi: 10.1371/journal.pone.0235981.Epub 2020-07-17.

細菌のエフェクターアーセナルのマッピング：細菌によるエフェクター分泌を規定するタンパク質の特徴を定義するためのin vivoおよびin silicoアプローチ

Mapping bacterial effector arsenals: in vivo and in silico approaches to defining the protein features dictating effector secretion by bacteria.
  • Yi Wei Lee
  • Jiawei Wang
  • Hayley J Newton
  • Trevor Lithgow
  • Curr. Opin. Microbiol..2020 Jun;57:13-21. S1369-5274(20)30041-2. doi: 10.1016/j.mib.2020.04.002.Epub 2020-06-04.

in vivoでのデュアルRNA-seqにより、好中球のリクルートが肺炎球菌の異なる組織トロピズムの根底にあることが明らかになった

In vivo dual RNA-seq reveals that neutrophil recruitment underlies differential tissue tropism of Streptococcus pneumoniae.
  • Vikrant Minhas
  • Rieza Aprianto
  • Lauren J McAllister
  • Hui Wang
  • Shannon C David
  • Kimberley T McLean
  • Iain Comerford
  • Shaun R McColl
  • James C Paton
  • Jan-Willem Veening
  • Claudia Trappetti
  • Commun Biol.2020 Jun;3(1):293. 10.1038/s42003-020-1018-x. doi: 10.1038/s42003-020-1018-x.Epub 2020-06-05.

発作性心房細動患者に対する第一選択療法としてのクライオバルーンカテーテルアブレーションと抗不整脈薬の比較。国際的なCryo-FIRST試験の根拠とデザイン

Cryoballoon catheter ablation versus antiarrhythmic drugs as a first-line therapy for patients with paroxysmal atrial fibrillation: Rationale and design of the international Cryo-FIRST study.
  • Jean Sylvain Hermida
  • Jian Chen
  • Christian Meyer
  • Saverio Iacopino
  • Giuseppe Arena
  • Nikola Pavlovic
  • Vedran Velagic
  • Stewart Healey
  • Douglas L Packer
  • Heinz-Friedrich Pitschner
  • Carlo de Asmundis
  • Malte Kuniss
  • Gian Battista Chierchia
  • Am. Heart J..2020 04;222:64-72. S0002-8703(19)30346-1. doi: 10.1016/j.ahj.2019.12.006.Epub 2019-12-18.

石炭曝露によるDNA損傷応答と細胞周期効果のシステム化学生物学的解析

Systems chemo-biology analysis of DNA damage response and cell cycle effects induced by coal exposure.
  • Jose F Torres-Ávila
  • Lyda Espitia-Pérez
  • Diego Bonatto
  • Fernanda Rabaioli da Silva
  • Iuri Marques de Oliveira
  • Luís F O Silva
  • Dione Silva Corrêa
  • Johnny Ferraz Dias
  • Juliana da Silva
  • João Antonio Pêgas Henriques
  • Genet. Mol. Biol..2020;43(3):e20190134. S1415-47572020000500501. doi: 10.1590/1678-4685-GMB-2019-0134.Epub 2020-06-26.

酵素活性化フルオロゲンプローブを用いたナチュラルキラー細胞からのグランザイムBの非侵襲的な光検出

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes.
  • Tomasz Janiszewski
  • Sonia Kołt
  • Dion Kaiserman
  • Scott J Snipas
  • Shuang Li
  • Julita Kulbacka
  • Jolanta Saczko
  • Niels Bovenschen
  • Guy Salvesen
  • Marcin Drąg
  • Phillip I Bird
  • Paulina Kasperkiewicz
  • J. Biol. Chem..2020 Jul;295(28):9567-9582. RA120.013204. doi: 10.1074/jbc.RA120.013204.Epub 2020-05-21.

DetEdit: 長期音響モニタリングデータから検出されたイベントをアノテーションして編集するためのグラフィカルなユーザーインターフェース

DetEdit: A graphical user interface for annotating and editing events detected in long-term acoustic monitoring data.
  • Alba Solsona-Berga
  • Kaitlin E Frasier
  • Simone Baumann-Pickering
  • Sean M Wiggins
  • John A Hildebrand
  • PLoS Comput. Biol..2020 01;16(1):e1007598. PCOMPBIOL-D-19-00708. doi: 10.1371/journal.pcbi.1007598.Epub 2020-01-13.

糖尿病の有無にかかわらず腎移植候補者の認知機能、腎移植へのアクセス、待機リスト死亡率

Cognitive Function, Access to Kidney Transplantation, and Waitlist Mortality Among Kidney Transplant Candidates With or Without Diabetes.
  • Nadia M Chu
  • Zhan Shi
  • Christine E Haugen
  • Silas P Norman
  • Alden L Gross
  • Daniel C Brennan
  • Michelle C Carlson
  • Dorry L Segev
  • Mara A McAdams-DeMarco
  • Am. J. Kidney Dis..2020 Jul;76(1):72-81. S0272-6386(19)31128-X. doi: 10.1053/j.ajkd.2019.10.014.Epub 2020-02-03.

2カ国の2つの3次紹介センターで受診した1331人の外傷後三叉神経障害患者の徴候と症状、QOL、心理社会的データ

Signs and symptoms, quality of life and psychosocial data in 1331 post-traumatic trigeminal neuropathy patients seen in two tertiary referral centres in two countries.
  • Fréderic Van der Cruyssen
  • Frederik Peeters
  • Thomas Gill
  • Antoon De Laat
  • Reinhilde Jacobs
  • Constantinus Politis
  • Tara Renton
  • J Oral Rehabil.2020 Jul;doi: 10.1111/joor.13058.Epub 2020-07-20.

焦点性レーザー治療を受けた中心性漿液性絨毛網膜症における適応光学系と眼底自家蛍光を用いた視細胞の評価

Photoreceptor assessment in focal laser-treated central serous chorioretinopathy using adaptive optics and fundus autofluorescence.
  • Radu Ochinciuc
  • Uliana Ochinciuc
  • Horia T Stanca
  • Ramona Barac
  • Diana Darabus
  • Marius Şuţă
  • Florian Baltă
  • Marian Burcea
  • Medicine (Baltimore).2020 Apr;99(15):e19536. 00005792-202004100-00012. doi: 10.1097/MD.0000000000019536.

D1ドーパミン受容体活性化後のhnRNP HのC末端ドメインとN末端ドメインにおける神経細胞免疫蛍光の変化

Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation.
  • Qiu T Ruan
  • Neema Yazdani
  • Jacob A Beierle
  • Kathryn M Hixson
  • Kristen E Hokenson
  • Daniel J Apicco
  • Kimberly P Luttik
  • Karen Zheng
  • Brandon F Maziuk
  • Peter E A Ash
  • Karen K Szumlinski
  • Shelley J Russek
  • Benjamin Wolozin
  • Camron D Bryant
  • Neurosci. Lett..2018 09;684:109-114. S0304-3940(18)30484-1. doi: 10.1016/j.neulet.2018.07.015.Epub 2018-07-09.

Microbiome and Insulin Longitudinal Evaluation Study（MILES）の根拠、デザイン、ベースラインの特徴

Rationale, Design, and Baseline Characteristics of the Microbiome and Insulin Longitudinal Evaluation Study (MILES).
  • Elizabeth T Jensen
  • Alain G Bertoni
  • Osa L Crago
  • Kristi L Hoffman
  • Alexis C Wood
  • Zorayr Arzumanyan
  • Lok-Sze Kelvin Lam
  • Kathryn Roll
  • Kevin Sandow
  • Martin Wu
  • Stephen S Rich
  • Jerome I Rotter
  • Yii-Der I Chen
  • Joseph F Petrosino
  • Mark O Goodarzi
  • Diabetes Obes Metab.2020 Jul;doi: 10.1111/dom.14145.Epub 2020-07-20.

コンピュータ制御のミルクフィーダーで給餌された雄性乳牛の行動、固形飼料摂取量、および成長能 力に及ぼす、ミルクの給餌戦略と食事のパターニングの制限の影響

The effect of milk feeding strategy and restriction of meal patterning on behavior, solid feed intake, and growth performance of male dairy calves fed via computer-controlled milk feeders.
  • Margit Bak Jensen
  • Annedorte Jensen
  • Mogens Vestergaard
  • J. Dairy Sci..2020 Jul;S0022-0302(20)30530-0. doi: 10.3168/jds.2020-18166.Epub 2020-07-16.

緑内障患者におけるQOLの主観的評価、視野欠損、および模擬日常生活活動におけるパフォーマンスの相関

Correlations between Subjective Evaluation of Quality of Life, Visual Field Loss and Performance in Simulated Activities of Daily Living in Glaucoma Patients.
  • Line Azoulay-Sebban
  • Zhanlin Zhao
  • Ariel Zenouda
  • Marco Lombardi
  • Emmanuel Gutman
  • Emmanuelle Brasnu
  • Pascale Hamard
  • José-Alain Sahel
  • Christophe Baudouin
  • Antoine Labbé
  • J. Glaucoma.2020 Jul;doi: 10.1097/IJG.0000000000001597.Epub 2020-07-03.

パルバルブミンの欠乏は、抑制性のPvalbニューロンのミトコンドリア量と樹状突起の分岐を増加させる

Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes.
  • Lucia Janickova
  • Karin Farah Rechberger
  • Lucas Wey
  • Beat Schwaller
  • Mol Autism.2020 Jun;11(1):47. 10.1186/s13229-020-00323-8. doi: 10.1186/s13229-020-00323-8.Epub 2020-06-09.

グルコーストランスポーター2と4は、ラット臼歯部のミネラル三酸化物凝集体を用いた歯髄切開後の歯髄創傷治癒時のグルコース供給に関与していることを明らかにした

Glucose Transporter 2 and 4 Are Involved in Glucose Supply during Pulpal Wound Healing after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars.
  • Aiko Tohma
  • Naoto Ohkura
  • Kunihiko Yoshiba
  • Ryosuke Takeuchi
  • Nagako Yoshiba
  • Naoki Edanami
  • Mari Shirakashi
  • Razi Saifullah Ibn Belal
  • Hayato Ohshima
  • Yuichiro Noiri
  • J Endod.2020 Jan;46(1):81-88. S0099-2399(19)30738-1. doi: 10.1016/j.joen.2019.10.003.Epub 2019-11-22.

SIAH1 の新規基質である TRAF4 は、SIAH1 によるβ-カテニンのダウンレギュレーションを抑制することで、乳癌細胞の化学療法抵抗性に関与していることが示唆された

TRAF4, a new substrate of SIAH1, participates in chemotherapy resistance of breast cancer cell by counteracting SIAH1-mediated downregulation of β-catenin.
  • Huayan Ren
  • Xiaoyi Mi
  • Pengyuan Zhao
  • Xueyan Zhao
  • Na Wei
  • Huifen Huang
  • Zhongqin Meng
  • Junna Kou
  • Mingfang Sun
  • Yuqiong Liu
  • Hongyan Zhang
  • Jianping Yang
  • Wencai Li
  • Huixiang Li
  • Breast Cancer Res. Treat..2020 Jul;10.1007/s10549-020-05789-x. doi: 10.1007/s10549-020-05789-x.Epub 2020-07-15.

非光性視覚サイクルと光性視覚サイクルは、錐体光受容体が媒介する視覚の即時、初期、後期の各段階で異なる制御を行っている

Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision.
  • Rebecca Ward
  • Joanna J Kaylor
  • Diego F Cobice
  • Dionissia A Pepe
  • Eoghan M McGarrigle
  • Susan E Brockerhoff
  • James B Hurley
  • Gabriel H Travis
  • Breandán N Kennedy
  • J. Biol. Chem..2020 May;295(19):6482-6497. RA119.011374. doi: 10.1074/jbc.RA119.011374.Epub 2020-04-01.

PEDOTベースの導電性ポリマーに電圧応答性ゲート付きメソポーラスシリカナノ粒子をグラフトした電気応答性フィルムを作製した

Electro-responsive films containing voltage responsive gated mesoporous silica nanoparticles grafted onto PEDOT-based conducting polymer.
  • Alba García-Fernández
  • Beatriz Lozano-Torres
  • Juan F Blandez
  • Javier Monreal-Trigo
  • Juan Soto
  • Jorge E Collazos-Castro
  • Miguel Alcañiz
  • María D Marcos
  • Félix Sancenón
  • Ramón Martínez-Máñez
  • J Control Release.2020 Jul;323:421-430. S0168-3659(20)30262-5. doi: 10.1016/j.jconrel.2020.04.048.Epub 2020-05-01.

ナイルティラピア(Oreochromis niloticus)におけるIL-6受容体(IL-6R)と糖タンパク質130(gp130)の分子・機能解析

Molecular and functional characterization of IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) in Nile tilapia (Oreochromis niloticus).
  • Enxu Zhou
  • Fangfang Yan
  • Bingxi Li
  • Meng Chen
  • Xiao Tu
  • Siwei Wu
  • Hairong Wu
  • Xiufang Wei
  • Shengli Fu
  • Liting Wu
  • Zheng Guo
  • Jianmin Ye
  • Dev. Comp. Immunol..2020 May;106:103629. S0145-305X(19)30559-2. doi: 10.1016/j.dci.2020.103629.Epub 2020-01-24.

人為的選択は、生活史の変化の維持における転写制約の役割を明らかにする

Artificial selection reveals the role of transcriptional constraints in the maintenance of life history variation.
  • Joel L Pick
  • Masaomi Hatakeyama
  • Kate E Ihle
  • Julien Gasparini
  • Claudy Haussy
  • Satoshi Ishishita
  • Yoichi Matsuda
  • Takashi Yoshimura
  • Masahiro M Kanaoka
  • Rie Shimizu-Inatsugi
  • Kentaro K Shimizu
  • Barbara Tschirren
  • Evol Lett.2020 Jun;4(3):200-211. EVL3166. doi: 10.1002/evl3.166.Epub 2020-04-07.

SARS-CoV-2のタンパク質構造におけるT細胞およびB細胞エピトープの免疫学的およびバイオインフォマティクス的同定：システマティックレビュー

Immune and bioinformatics identification of T cell and B cell epitopes in the protein structure of SARS-CoV-2: A systematic review.
  • Zahra Noorimotlagh
  • Chiman Karami
  • Seyyed Abbas Mirzaee
  • Mohammadreza Kaffashian
  • Sanaz Mami
  • Mahdieh Azizi
  • Int. Immunopharmacol..2020 Jun;86:106738. S1567-5769(20)31382-5. doi: 10.1016/j.intimp.2020.106738.Epub 2020-06-28.

体積測定変数に基づくHIVと共存する小児および青年の面積骨ミネラル密度および骨ミネラル含有量の予測．

Prediction of Areal Bone Mineral Density and Bone Mineral Content in Children and Adolescents Living With HIV Based on Anthropometric Variables.
  • Luiz Rodrigo Augustemak de Lima
  • Rodrigo de Rosso Krug
  • Rosane Carla Rosendo da Silva
  • Aroldo Prohmann de Carvalho
  • David Alejandro González-Chica
  • Isabela de Carlos Back
  • Edio Luiz Petroski
  • J Clin Densitom.2016 10;19(4):457-464. S1094-6950(15)00129-8. doi: 10.1016/j.jocd.2015.06.001.Epub 2015-07-20.

ブラジルの職人的チーズから初めてコキシエラ・バーネティイの分子検出：生乳製品の食品安全上の危険性が無視されてきたこと

First molecular detection of Coxiella burnetii in Brazilian artisanal cheese: a neglected food safety hazard in ready-to-eat raw-milk product.
  • Tatiana Rozental
  • Letícia Scafutto De Faria
  • Danielle Forneas
  • Alexandro Guterres
  • João Batista Ribeiro
  • Flábio Ribeiro Araújo
  • Elba Regina Sampaio Lemos
  • Marcio Roberto Silva
  • Braz J Infect Dis.2020 May - Jun;24(3):208-212. S1413-8670(20)30064-7. doi: 10.1016/j.bjid.2020.05.003.Epub 2020-06-18.

ゴナドトロピン抑制ホルモン（GnIH）の発見、生殖生理と行動に関するGnIH研究の進展、生殖の神経内分泌制御に関するGnIH研究の展望についてまとめた

Discovery of gonadotropin-inhibitory hormone (GnIH), progress in GnIH research on reproductive physiology and behavior and perspective of GnIH research on neuroendocrine regulation of reproduction.
  • Kazuyoshi Tsutsui
  • Takayoshi Ubuka
  • Mol. Cell. Endocrinol..2020 Jun;514:110914. S0303-7207(20)30214-8. doi: 10.1016/j.mce.2020.110914.Epub 2020-06-12.

DIS3L2はhnRNP U介在性代替スプライシングを介して肝細胞癌の進行を促進する

DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing.
  • Songge Xing
  • Zhaoyong Li
  • Wenhao Ma
  • Xiaoping He
  • Shengqi Shen
  • Haoran Wei
  • Shi-Ting Li
  • Ying Shu
  • Linchong Sun
  • Xiuying Zhong
  • Yuhao Huangfu
  • Lanhong Su
  • Junru Feng
  • Xiaozhang Zhang
  • Ping Gao
  • Wei-Dong Jia
  • Huafeng Zhang
  • Cancer Res..2019 Oct;79(19):4923-4936. 0008-5472.CAN-19-0376. doi: 10.1158/0008-5472.CAN-19-0376.Epub 2019-07-22.

高分子電解質錯体化と超高圧ホモジナイゼーション（UHPH）によるアンピシリンを担持した高分子電解質錯体ナノ粒子（PECN）の開発

Development of Polyelectrolyte Complex Nanoparticles-PECNs Loaded with Ampicillin by Means of Polyelectrolyte Complexation and Ultra-High Pressure Homogenization (UHPH).
  • Nicolle Montero
  • Maria J Alhajj
  • Mariana Sierra
  • Jose Oñate-Garzon
  • Cristhian J Yarce
  • Constain H Salamanca
  • Polymers (Basel).2020 May;12(5). E1168. doi: 10.3390/polym12051168.Epub 2020-05-20.

アラキドン酸は、カルシウムイオンの非存在下で、5-リポキシゲナーゼ活性化タンパク質を含むナノディスクへの5-リポキシゲナーゼの結合を促進する

Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions.
  • Ramakrishnan B Kumar
  • Pasi Purhonen
  • Hans Hebert
  • Caroline Jegerschöld
  • PLoS ONE.2020;15(7):e0228607. PONE-D-20-01617. doi: 10.1371/journal.pone.0228607.Epub 2020-07-09.

マルチオミクスデータの統合により、ネットリン1受容体（DCC）がうつ病リスク遺伝子であることをさらに確認した

Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data.
  • Hui-Juan Li
  • Na Qu
  • Li Hui
  • Xin Cai
  • Chu-Yi Zhang
  • Bao-Liang Zhong
  • Shu-Fang Zhang
  • Jing Chen
  • Bin Xia
  • Lu Wang
  • Qiu-Fang Jia
  • Wei Li
  • Hong Chang
  • Xiao Xiao
  • Ming Li
  • Yi Li
  • Transl Psychiatry.2020 Mar;10(1):98. 10.1038/s41398-020-0777-y. doi: 10.1038/s41398-020-0777-y.Epub 2020-03-17.

構成性アンドロステイン受容体（CAR）のアゴニスティックリガンドの同定のためのエピトープタグ付きタンパク質を用いた新しい細胞ベースのレポーターアッセイシステム

Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR).
  • Jun Imai
  • Yasushi Yamazoe
  • Kouichi Yoshinari
  • Drug Metab. Pharmacokinet..2013;28(4):290-8. DN/JST.JSTAGE/dmpk/DMPK-12-RG-112. doi: 10.2133/dmpk.dmpk-12-rg-112.Epub 2012-12-25.

カドミウムとストロンチウムの処理のための植物抽出と結合したバイオオーグメンテーション、およびホスホギプサムの希土類元素の再利用の機会

Bioaugmentation coupled with phytoextraction for the treatment of Cd and Sr, and reuse opportunities for phosphogypsum rare earth elements.
  • Jihen Jalali
  • Pierre Gaudin
  • Emna Ammar
  • Thierry Lebeau
  • J. Hazard. Mater..2020 May;399:122821. S0304-3894(20)30810-4. doi: 10.1016/j.jhazmat.2020.122821.Epub 2020-05-21.

ホスファチジルイノシトール-4-リン酸5-キナーゼ1αは、アミロイド前駆体タンパク質の非アミロイド性処理を促進することで、Aβ産生を抑制します

Phosphatidylinositol-4-phosphate 5-kinase type 1α attenuates Aβ production by promoting non-amyloidogenic processing of amyloid precursor protein.
  • Po-Fan Wu
  • Noopur Bhore
  • Yen-Lurk Lee
  • Ju-Yun Chou
  • Yun-Wen Chen
  • Pei-Yi Wu
  • Wen-Ming Hsu
  • Hsinyu Lee
  • Yi-Shuian Huang
  • Pei-Jung Lu
  • Yung-Feng Liao
  • FASEB J..2020 Jul;doi: 10.1096/fj.202000113R.Epub 2020-07-20.

TRIM72を標的とした自己抗体は、膜修復を阻害し、炎症性ミオパチーの一因となる

Autoantibodies targeting TRIM72 compromise membrane repair and contribute to inflammatory myopathy.
  • Kevin E McElhanon
  • Nicholas Young
  • Jeffrey Hampton
  • Brian J Paleo
  • Thomas A Kwiatkowski
  • Eric X Beck
  • Ana Capati
  • Kyle Jablonski
  • Travis Gurney
  • Miguel A Lopez Perez
  • Rohit Aggarwal
  • Chester V Oddis
  • Wael N Jarjour
  • Noah Weisleder
  • J. Clin. Invest..2020 Jul;131721. doi: 10.1172/JCI131721.Epub 2020-07-20.

廃水処理プラントにおけるマイクロプラスチック除去のための有望な戦略としてのバイオレメディエーション

Bioremediation as a promising strategy for microplastics removal in wastewater treatment plants.
  • Paula Masiá
  • Daniel Sol
  • Alba Ardura
  • Amanda Laca
  • Yaisel J Borrell
  • Eduardo Dopico
  • Adriana Laca
  • Gonzalo Machado-Schiaffino
  • Mario Díaz
  • Eva Garcia-Vazquez
  • Mar. Pollut. Bull..2020 Jul;156:111252. S0025-326X(20)30370-2. doi: 10.1016/j.marpolbul.2020.111252.Epub 2020-05-22.

トウモロコシ（Zea mays）のセンサーベースの評価と、作物の種子処理または除草剤混合パートナーとして適用されたイソキサフルトールとシプロスルファミドの出穂後除草剤散布に対する雑草の反応

Sensor-based evaluation of maize (Zea mays) and weed response to post-emergence herbicide applications of Isoxaflutole and Cyprosulfamide applied as crop seed treatment or herbicide mixing partner.
  • Robin Mink
  • Alexander Ingo Linn
  • Hans-Joachim Santel
  • Roland Gerhards
  • Pest Manag. Sci..2020 May;76(5):1856-1865. doi: 10.1002/ps.5715.Epub 2020-01-13.

遺伝的疫学から、パキスタンでのポリオウイルス撲滅を困難にしている人口移動が再発する3つの慢性貯水池地域が明らかになりました

Genetic Epidemiology reveals three chronic reservoir areas with recurrent population mobility challenging poliovirus eradication in Pakistan.
  • Ribqa Akhtar
  • Nayab Mahmood
  • Muhammad Masroor Alam
  • Muhammad Naeem
  • Sohail Zahoor Zaidi
  • Salman Sharif
  • Zainab Khattak
  • Yasir Arshad
  • Adnan Khurshid
  • Ghulam Mujtaba
  • Lubna Rehman
  • Mehar Angez
  • Shehzad Shaukat
  • Nighat Mushtaq
  • Massab Umair
  • Aamer Ikram
  • Muhammad Salman
  • Clin. Infect. Dis..2019 Oct;ciz1037. doi: 10.1093/cid/ciz1037.Epub 2019-10-26.