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日本語AIでPubMedを検索

歯科医師情報サイトTOP / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
対象期間    ～ 

2020年07月 みんなが読んでいる論文

半島マレーシア出身の東南アジア系インド人271人におけるHLA-A、-B、-C、-DRB1、-DQB1対立遺伝子とハプロタイプ

HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 271 Southeast Asia Indians from Peninsular Malaysia.
  • Ahmad Fauzi Nurul-Aain
  • Lay-Kim Tan
  • Hussein Heselynn
  • Shahril Nor-Shuhaila
  • Mageswaran Eashwary
  • Sulaiman Wahinuddin
  • Ing Soo Lau
  • Suk Chyn Gun
  • Mohamed-Said Mohd-Shahrir
  • Mohd-Mokhtar Ainon
  • Rosman Azmillah
  • Othman Muhaini
  • Murad Shahnaz
  • Chun-Lai Too
  • Hum. Immunol..2020 Jun;81(6):263-264. S0198-8859(20)30220-2. doi: 10.1016/j.humimm.2020.04.004.Epub 2020-04-18.

嗅上皮における自然免疫シグナル伝達は、嗅覚受容体レベルを低下させる：COVID-19患者における一過性の嗅覚喪失をモデル化する

Innate immune signaling in the olfactory epithelium reduces odorant receptor levels: modeling transient smell loss in COVID-19 patients.
  • Steve Rodriguez
  • Luxiang Cao
  • Gregory T Rickenbacher
  • Eric G Benz
  • Colin Magdamo
  • Liliana A Ramirez Gomez
  • Eric Holbrook
  • Alefiya Dhilla Albers
  • Rose Gallagher
  • M Brandon Westover
  • Kyle E Evans
  • Daniel Tatar
  • Shibani Mukerji
  • Ross Zafonte
  • Edward W Boyer
  • C Ron Yu
  • Mark W Albers
  • medRxiv.2020 Jun;2020.06.14.20131128. doi: 10.1101/2020.06.14.20131128.Epub 2020-06-16.

Poincianella pyramidalis (Tul) L.P. Queiroz: 伝統的用途、植物化学、生物学的薬理活性に関するレビュー

Poincianella pyramidalis (Tul) L.P. Queiroz: A review on traditional uses, phytochemistry and biological-pharmacological activities.
  • Leide Maria Soares de Sousa
  • Brenda N G Santos
  • Maria das Graças F Medeiros
  • Izabela B C Lima
  • Francisco Soares Santos-Filho
  • Ana Cristina S G V Santana
  • Lina C G A I Moreno
  • Lívio C C Nunes
  • J Ethnopharmacol.2020 Jul;:113181. S0378-8741(20)33063-4. doi: 10.1016/j.jep.2020.113181.Epub 2020-07-17.

雄性ラットにおける慢性リチウム投与後の運動衝動性の低下は、眼窩前頭前皮質の炎症性サイトカインレベルの低下と関連している

Decreased motor impulsivity following chronic lithium treatment in male rats is associated with reduced levels of pro-inflammatory cytokines in the orbitofrontal cortex.
  • Wendy K Adams
  • Dominique L Levesque
  • Paul J Cocker
  • Sukhbir Kaur
  • Tamara S Bodnar
  • Allan H Young
  • Catharine A Winstanley
  • Brain Behav. Immun..2020 Jul;S0889-1591(20)30512-2. doi: 10.1016/j.bbi.2020.07.018.Epub 2020-07-17.

飢餓を生き抜く。プロテオミクスおよびリピドミクスプロファイリングによる、最も小さな既知の自由に生きる真核生物の栄養欠乏のプロファイリング

Surviving Starvation: Proteomic and Lipidomic Profiling of Nutrient Deprivation in the Smallest Known Free-Living Eukaryote.
  • Sarah F Martin
  • Mary K Doherty
  • Eliane Salvo-Chirnside
  • Seshu R Tammireddy
  • Jiaxiuyu Liu
  • Thierry Le Bihan
  • Phillip D Whitfield
  • Metabolites.2020 Jul;10(7). E273. doi: 10.3390/metabo10070273.Epub 2020-07-03.

2色および3色のSTORM解析により、マウス好中球の核内包膜上でのロイコトリエン合成複合体の高次集合体を明らかにした

Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils.
  • Angela B Schmider
  • Nicholas C Bauer
  • Hongjae Sunwoo
  • Matthew D Godin
  • Giorgianna E Ellis
  • Jeannie T Lee
  • Peter A Nigrovic
  • Roy J Soberman
  • J. Biol. Chem..2020 Apr;295(17):5761-5770. RA119.012069. doi: 10.1074/jbc.RA119.012069.Epub 2020-03-09.

栄養学から医学へ。Solanum melongena L.の痔治療活性をin vivo実験モデルと主要化学物質を介して評価する

From Nutrition to Medicine: Assessing hemorrhoid healing activity of Solanum melongena L. via in vivo experimental models and its major chemicals.
  • Ceylan Dönmez
  • Funda N Yalçın
  • Özge Boyacıoğlu
  • Petek Korkusuz
  • Esra Küpeli Akkol
  • Emirhan Nemutlu
  • Yasemin H Balaban
  • Ufuk Koca Caliskan
  • J Ethnopharmacol.2020 Jul;:113143. S0378-8741(20)33025-7. doi: 10.1016/j.jep.2020.113143.Epub 2020-07-17.

菌体の細胞壁のプロテオミクス解析から、メナジオンによる酸化ストレス応答に関与するタンパク質を明らかにした

Proteomic analysis of Sporothrix schenckii cell wall reveals proteins involved in oxidative stress response induced by menadione.
  • Carlos Félix-Contreras
  • Carlos A Alba-Fierro
  • Emmanuel Ríos-Castro
  • Francisco Luna-Martínez
  • Mayra Cuéllar-Cruz
  • Estela Ruiz-Baca
  • Microb. Pathog..2020 Apr;141:103987. S0882-4010(19)31687-0. doi: 10.1016/j.micpath.2020.103987.Epub 2020-01-19.

葉の抽出物とヒト血清アルブミンの相互作用への生物物理学的洞察は、生物学的に強力な抗菌性と抗がん性の金ナノ粒子を触発した

Biophysical insights into the interaction of human serum albumin with leaf extracts inspired biogenic potent antibacterial and anticancerous gold nanoparticles.
  • Maidul Beg
  • Anukul Maji
  • Sk Nayim
  • Mt Nasima Aktara
  • Nandan Kumar Sahoo
  • Gopal Chandra Jana
  • Md Maidul Islam
  • Maidul Hossain
  • J. Biomol. Struct. Dyn..2020 Jun;:1-15. doi: 10.1080/07391102.2020.1778532.Epub 2020-06-22.

ヒト特異的インプリンティング遺伝子の欠損は出生前成長遅延と異形性を引き起こす：シルバーラッセル症候群との表現型重複の意味合い

Loss of imprinting of the human-specific imprinted gene causes prenatal growth retardation and dysmorphic features: implications for phenotypic overlap with Silver-Russell syndrome.
  • Kazuki Yamazawa
  • Takanobu Inoue
  • Yoshihiro Sakemi
  • Toshinori Nakashima
  • Hironori Yamashita
  • Kaduki Khono
  • Hideki Fujita
  • Keisuke Enomoto
  • Kazuhiko Nakabayashi
  • Kenichiro Hata
  • Moeko Nakashima
  • Tatsuo Matsunaga
  • Akie Nakamura
  • Keiko Matsubara
  • Tsutomu Ogata
  • Masayo Kagami
  • J. Med. Genet..2020 Jun;jmedgenet-2020-107019. doi: 10.1136/jmedgenet-2020-107019.Epub 2020-06-23.

キサンチン系色素との簡便な錯体形成によるマレイン酸アセナピンの定量のためのワンポット反応。含有量均一性試験への応用

One-pot reaction for determination of Asenapine maleate through facile complex formation with xanthine based dye: Application to content uniformity test.
  • Ahmed A Abu-Hassan
  • Ramadan Ali
  • Sayed M Derayea
  • Spectrochim Acta A Mol Biomol Spectrosc.2020 Oct;239:118474. S1386-1425(20)30452-2. doi: 10.1016/j.saa.2020.118474.Epub 2020-05-14.

合成ゲノミクスプラットフォームを用いたSARS-CoV-2の迅速な再構築

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform.
  • Tran Thi Nhu Thao
  • Fabien Labroussaa
  • Nadine Ebert
  • Philip V'kovski
  • Hanspeter Stalder
  • Jasmine Portmann
  • Jenna Kelly
  • Silvio Steiner
  • Melle Holwerda
  • Annika Kratzel
  • Mitra Gultom
  • Kimberly Schmied
  • Laura Laloli
  • Linda Hüsser
  • Manon Wider
  • Stephanie Pfaender
  • Dagny Hirt
  • Valentina Cippà
  • Silvia Crespo-Pomar
  • Simon Schröder
  • Doreen Muth
  • Daniela Niemeyer
  • Victor M Corman
  • Marcel A Müller
  • Christian Drosten
  • Ronald Dijkman
  • Joerg Jores
  • Volker Thiel
  • Nature.2020 06;582(7813):561-565. 10.1038/s41586-020-2294-9. doi: 10.1038/s41586-020-2294-9.Epub 2020-05-04.

キセノエストロゲン神経毒性と甲状腺機能障害の評価のための複合的アプローチ。酸化窒素マーカー、DNA断片化、生体アミン分解のスクリーニング

Combined approaches for evaluation of xenoestrogen neural toxicity and thyroid dysfunction: Screening of oxido-nitrosative markers, DNA fragmentation, and biogenic amine degradation.
  • Mohamed Taha
  • Abeer M Marie
  • Omar A Ahmed-Farid
  • J. Biochem. Mol. Toxicol..2020 Jun;:e22521. doi: 10.1002/jbt.22521.Epub 2020-06-03.

DPP-4阻害は、高インスリン血症マウスモデルにおいて、肝プロテインキナーゼCの発現を阻害することで、運動と同様に2型糖尿病の発症を抑制することが示唆された

DPP-4 inhibition resembles exercise in preventing type 2 diabetes development by inhibiting hepatic protein kinase C expression in a mouse model of hyperinsulinemia.
  • Yu-Peng Li
  • Jing Xiao
  • Xu Liang
  • Yu Pei
  • Xiao-Fei Han
  • Chen-Xi Li
  • Hui Tian
  • J. Int. Med. Res..2020 Jun;48(6):300060520934635. doi: 10.1177/0300060520934635.

肺癌におけるインドシアニングリーンを用いたセンチネルリンパ節生検の診断精度：システマティックレビューとメタアナリシス

Diagnostic accuracy of sentinel lymph node biopsy using indocyanine green in lung cancer: a systematic review and meta-analysis.
  • Warren Y L Sun
  • Jerry T Dang
  • Aryan Modasi
  • Awrad Nasralla
  • Noah J Switzer
  • Daniel Birch
  • Simon R Turner
  • Shahzeer Karmali
  • Gen Thorac Cardiovasc Surg.2020 Jun;10.1007/s11748-020-01400-8. doi: 10.1007/s11748-020-01400-8.Epub 2020-06-16.

アンジオポエチン-1、アンジオポエチン-2およびTie-2受容体のレベルに対する食事性および血漿中の葉酸およびコバラミンの寄与は、原発性乳がん患者の血管内皮増殖因子の状態に依存する

The contribution of dietary and plasma folate and cobalamin to levels of angiopoietin-1, angiopoietin-2 and Tie-2 receptors depend on vascular endothelial growth factor status of primary breast cancer patients.
  • Saeed Pirouzpanah
  • Parisa Varshosaz
  • Ashraf Fakhrjou
  • Vahid Montazeri
  • Sci Rep.2019 10;9(1):14851. 10.1038/s41598-019-51050-x. doi: 10.1038/s41598-019-51050-x.Epub 2019-10-16.

選択された慢性疾患を持つ患者のFmdレベルに対する炎症、酸化ストレス、内皮機能障害の修正の効果。準実験的研究

The Effect of Corrected Inflammation, Oxidative Stress and Endothelial Dysfunction on Fmd Levels in Patients with Selected Chronic Diseases: A Quasi-Experimental Study.
  • Mahmut Ilker Yilmaz
  • Micol Romano
  • Mustafa Kemal Basarali
  • Abdelbaset Elzagallaai
  • Murat Karaman
  • Zeynep Demir
  • Muhammet Fatih Demir
  • Fatih Akcay
  • Melik Seyrek
  • Nuri Haksever
  • David Piskin
  • Rolando Cimaz
  • Michael J Rieder
  • Erkan Demirkaya
  • Sci Rep.2020 Jun;10(1):9018. 10.1038/s41598-020-65528-6. doi: 10.1038/s41598-020-65528-6.Epub 2020-06-02.

SUMO1媒介のSUMOylationを阻害すると、オートファジー媒介のがん細胞死が誘導され、RAC1を介して腫瘍細胞の浸潤が減少する

Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1.
  • Mar Lorente
  • Ana García-Casas
  • Nélida Salvador
  • Angélica Martínez-López
  • Estibaliz Gabicagogeascoa
  • Guillermo Velasco
  • Lucía López-Palomar
  • Sonia Castillo-Lluva
  • J. Cell. Sci..2019 10;132(20). jcs234120. doi: 10.1242/jcs.234120.Epub 2019-10-22.

根治的膀胱摘出術で治療された大型膀胱癌コホートにおけるFGFR3変異状況とFGFR3発現：抗FGFR3治療への示唆？

FGFR3 Mutation Status and FGFR3 Expression in a Large Bladder Cancer Cohort Treated by Radical Cystectomy: Implications for Anti-FGFR3 Treatment?.
  • Bas W G van Rhijn
  • Laura S Mertens
  • Roman Mayr
  • Peter J Bostrom
  • Francisco X Real
  • Ellen C Zwarthoff
  • Joost L Boormans
  • Cheno Abas
  • Geert J L H van Leenders
  • Stefanie Götz
  • Katrin Hippe
  • Simone Bertz
  • Yann Neuzillet
  • Joyce Sanders
  • Annegien Broeks
  • Michiel S van der Heijden
  • Michael A S Jewett
  • Mirari Marquez
  • Robert Stoehr
  • Alexandre R Zlotta
  • Markus Eckstein
  • Yanish Soorojebally
  • Hossain Roshani
  • Maximilian Burger
  • Wolfgang Otto
  • François Radvanyi
  • Nanor Sirab
  • Damien Pouessel
  • Bernd Wullich
  • Theo H van der Kwast
  • Núria Malats
  • Arndt Hartmann
  • Yves Allory
  • Tahlita C M Zuiverloon
  • Eur. Urol..2020 Jul;S0302-2838(20)30531-5. doi: 10.1016/j.eururo.2020.07.002.Epub 2020-07-15.

Jessica Y. ShimとMarc R. Lauferの編集者への書簡re: Proposal of the 3O (Obstruction, Ureteric Orifice, and Outcome) Subclassification System Associated Associated with Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA)」への返信

Reply to Jessica Y. Shim and Marc R. Laufer's letter to the editor re: Proposal of the 3O (Obstruction, Ureteric Orifice, and Outcome) Subclassification System Associated with Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA)".
  • Junjie Zhang
  • Yu Zhang
  • Long Wang
  • J Pediatr Adolesc Gynecol.2020 Jul;S1083-3188(20)30280-1. doi: 10.1016/j.jpag.2020.07.004.Epub 2020-07-16.

マヌマイシンAは、去勢抵抗性前立腺癌細胞におけるRas/Raf/ERK1/2シグナルとhnRNP H1の標的的阻害を介してエキソソソームの生合成と分泌を抑制します

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.
  • Amrita Datta
  • Hogyoung Kim
  • Madhu Lal
  • Lauren McGee
  • Adedoyin Johnson
  • Ahmed A Moustafa
  • Jennifer C Jones
  • Debasis Mondal
  • Marc Ferrer
  • Asim B Abdel-Mageed
  • Cancer Lett..2017 11;408:73-81. S0304-3835(17)30507-4. doi: 10.1016/j.canlet.2017.08.020.Epub 2017-08-24.

腹腔鏡下スリーブ胃切除術後の体重再燃に対する単一吻合十二指腸胆道バイパス術の短期から中期の結果を単一吻合胃バイパス術と比較した

Short- to medium-term results of single-anastomosis duodeno-ileal bypass compared with one-anastomosis gastric bypass for weight recidivism after laparoscopic sleeve gastrectomy.
  • Marlon de la Cruz
  • Martin Büsing
  • Radostina Dukovska
  • Antonio José Torres
  • Markus Reiser
  • Surg Obes Relat Dis.2020 Apr;S1550-7289(20)30198-2. doi: 10.1016/j.soard.2020.04.014.Epub 2020-04-21.

触媒ドメイン内の疎水性ポケットとチャネルの両方に結合する強力なオートタキシン阻害剤の同定

Identification of Potent Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain.
  • Mitsuyasu Kawaguchi
  • Takayoshi Okabe
  • Shinichi Okudaira
  • Kotaro Hama
  • Kuniyuki Kano
  • Hiroshi Nishimasu
  • Hidehiko Nakagawa
  • Ryuichiro Ishitani
  • Hirotatsu Kojima
  • Osamu Nureki
  • Junken Aoki
  • Tetsuo Nagano
  • J. Med. Chem..2020 Mar;63(6):3188-3204. doi: 10.1021/acs.jmedchem.9b01967.Epub 2020-03-13.

泌尿器科医を対象とした前立腺肥大症に対する解剖学的内視鏡下前立腺摘出術に関する世界的な知識、態度、実践に関する調査

A global knowledge, attitudes and practices survey on anatomical endoscopic enucleation of prostate for benign prostatic hyperplasia among urologists.
  • Kalyan Gudaru
  • Daniel A Gonzalez Padilla
  • Daniele Castellani
  • Leonardo Tortolero Blanco
  • Yiloren Tanidir
  • Lo Ka Lun
  • Marcelo Langer Wroclawski
  • Pankaj N Maheshwari
  • Felipe Carvalho A De Figueiredo
  • Jeremy Yuen-Chun Teoh
  • Andrologia.2020 Jun;:e13717. doi: 10.1111/and.13717.Epub 2020-06-28.

Milnacipran HClの新規キトサン-ポリカプロラクトンベースの粘接着性胃保持性徐放性薬物送達システムのin vivo評価

In Vivo Evaluation of a Novel Chitosan-Polycaprolactone Based Mucoadhesive Gastro-Retentive Sustained Release Drug Delivery System for Milnacipran HCl.
  • Talib Hussain
  • Muhammad Ijaz
  • Rahat Shamim
  • Khalid Hussain
  • Nasir Abbas
  • Amjad Hussain
  • Julia Anita Griessinger
  • Nadeem Irfan Bukhari
  • AAPS PharmSciTech.2020 Jan;21(2):58. 10.1208/s12249-019-1606-6. doi: 10.1208/s12249-019-1606-6.Epub 2020-01-07.

生きた骨芽細胞の細胞外マトリックス蛋白質のダイナミックイメージングによる細胞外マトリックスの集合と再編成に関する新たな知見を得た

New insights into extracellular matrix assembly and reorganization from dynamic imaging of extracellular matrix proteins in living osteoblasts.
  • Pitchumani Sivakumar
  • Andras Czirok
  • Brenda J Rongish
  • Vivek P Divakara
  • Yu-Ping Wang
  • Sarah L Dallas
  • J. Cell. Sci..2006 Apr;119(Pt 7):1350-60. jcs.02830. doi: 10.1242/jcs.02830.Epub 2006-03-14.

ステント留置を伴う血管形成術後の冠動脈心疾患患者における望ましくない冠動脈イベントの予後と脂質プロファイルパラメータおよび血管炎症反応のマーカーのプロスペクティブ解析

[Prospective analysis of lipid profile parameters and markers of vascular inflammatory response with prognosis of undesirable coronary events in patients with coronary heart disease after angioplasty with stenting.]
  • T I Petelina
  • N A Musikhina
  • L I Gapon
  • E A Gorbatenko
  • S M Dyachkov
  • Yu A Sharoyan
  • E V Zueva
  • Klin. Lab. Diagn..2018;63(8):471-477. doi: 10.18821/0869-2084-2018-63-8-471-477.

後期パーキンソン病における神経精神症状の有病率と決定因子

The Prevalence and Determinants of Neuropsychiatric Symptoms in Late-Stage Parkinsonism.
  • Adrianus L A J Hommel
  • Marjan J Meinders
  • Stefan Lorenzl
  • Richard Dodel
  • Miguel Coelho
  • Joaquim J Ferreira
  • Brice Laurens
  • Umberto Spampinato
  • Wassilios Meissner
  • Kristina Rosqvist
  • Jonathan Timpka
  • Per Odin
  • Michael Wittenberg
  • Bas R Bloem PhD
  • Raymond T Koopmans
  • Anette Schrag
  • Mov Disord Clin Pract.2020 Jul;7(5):531-542. MDC312968. doi: 10.1002/mdc3.12968.Epub 2020-05-21.

間葉系幹細胞の椎間板への移植は、Tie2陽性前駆細胞数を増加させ、細胞死を防ぎ、増殖反応を誘導する

Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response.
  • Sebastian Wangler
  • Marianna Peroglio
  • Ursula Menzel
  • Lorin M Benneker
  • Lisbet Haglund
  • Daisuke Sakai
  • Mauro Alini
  • Sibylle Grad
  • Spine.2019 Dec;44(23):1613-1622. 00007632-201912010-00002. doi: 10.1097/BRS.0000000000003150.

次世代シークエンシング時代の慢性リンパ性白血病における免疫グロブリン遺伝子解析

Immunoglobulin gene analysis in chronic lymphocytic leukemia in the era of next generation sequencing.
  • Frédéric Davi
  • Anton W Langerak
  • Anne Langlois de Septenville
  • P Martijn Kolijn
  • Paul J Hengeveld
  • Anastasia Chatzidimitriou
  • Silvia Bonfiglio
  • Lesley-Ann Sutton
  • Richard Rosenquist
  • Paolo Ghia
  • Kostas Stamatopoulos
  • Leukemia.2020 Jun;10.1038/s41375-020-0923-9. doi: 10.1038/s41375-020-0923-9.Epub 2020-06-19.

成人T細胞白血病/リンパ腫の維持療法としての三酸化ヒ素（AsO）

Arsenic trioxide (AsO) as a maintenance therapy for adult T cell leukemia/lymphoma.
  • Ambroise Marçais
  • Lucy Cook
  • Aviva Witkover
  • Vahid Asnafi
  • Véronique Avettand-Fenoel
  • Richard Delarue
  • Morgane Cheminant
  • David Sibon
  • Laurent Frenzel
  • Hugues de Thé
  • Charles R M Bangham
  • Ali Bazarbachi
  • Olivier Hermine
  • Felipe Suarez
  • Retrovirology.2020 03;17(1):5. 10.1186/s12977-020-0513-y. doi: 10.1186/s12977-020-0513-y.Epub 2020-03-21.

厳選された漢方薬用植物の抗酸化・抗炎症活性および抗酸化含有量との関係

Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content.
  • Anjaneya S Ravipati
  • Lin Zhang
  • Sundar Rao Koyyalamudi
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喫煙暴露後の心筋梗塞誘発性腎障害における性差：閉経前の雌マウスではより多くの腎保護が得られる

Sex-based differences in myocardial infarction-induced kidney damage following cigarette smoking exposure: more renal protection in premenopausal female mice.
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紫サツマイモのタンパク質結合型アントシアニン化合物が高脂肪食/ストレプトゾトシン誘発糖尿病マウスの肝グルコース代謝を制御して高血糖を改善することを明らかにした

Protein-Bound Anthocyanin Compounds of Purple Sweet Potato Ameliorate Hyperglycemia by Regulating Hepatic Glucose Metabolism in High-Fat Diet/Streptozotocin-Induced Diabetic Mice.
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メキシコで採取されたRhipicephalus microplusのATAQ遺伝子の遺伝的多様性と抗マダニワクチンとしての意味合い

Genetic diversity of the ATAQ gene in Rhipicephalus microplus collected in Mexico and implications as anti-tick vaccine.
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ナイジェリア南西部の第三次整形外科における先天性手指異常のパターン。10年間の横断的レトロスペクティブレビュー

Pattern of congenital hand anomalies at a tertiary plastic surgery service in South-Western Nigeria: A 10-year, cross-sectional retrospective review.
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帝王切開術後のErector Spinae Plane Blockと腹横筋Plane Blockの鎮痛効果の比較。積極的無作為化単盲検対照研究

Comparison of Analgesic Effect Between Erector Spinae Plane Block and Transversus Abdominis Plane Block After Elective Cesarean Section: A Prospective Randomized Single-Blind Controlled Study.
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大腸癌における循環25-OHビタミンDの変動と分泌されたフリル関連タンパク質2のメチル化との関連性

Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer.
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ブラジルでヒト免疫不全ウイルス（HIV）と生活している女性およびマッチした HIV 陰性対照者における子宮頸部および口腔内ヒトパピローマウイルス感染症

Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil.
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  • Edilson Damke
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ALDH5A1のバイアレル変異はコハク性セマルアルデヒドデヒドロゲナーゼ欠損症と重度の知的障害と関連しています

Bi-allelic Mutations in ALDH5A1 is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability.
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  • Afagh Alavi
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成人ラットにおける2-ヒドロキシプロピル-β-シクロデキストリン耳毒性。臨界量以上の内毛および外毛細胞の急速な発症と大規模な破壊

2-Hydroxypropyl-β-cyclodextrin Ototoxicity in Adult Rats: Rapid Onset and Massive Destruction of Both Inner and Outer Hair Cells Above a Critical Dose.
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  • Dalian Ding
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  • Neurotox Res.2020 Jun;10.1007/s12640-020-00252-7. doi: 10.1007/s12640-020-00252-7.Epub 2020-06-30.

レドックス活性なdpp-Bian配位子を含む電子欠損ガリウム・アルミニウム種の合成とε-カプロラクトン重合活性

Synthesis and ε-Caprolactone Polymerization Activity of Electron-Deficient Gallium and Aluminum Species Containing a Charged Redox-Active dpp-Bian Ligand.
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組織浸潤性マクロファージは、DNA損傷時にエクソソームベースの代謝リプログラミングを媒介する

Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage.
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  • Maria Tsekrekou
  • Kalliopi Stratigi
  • Ioanna K Poutakidou
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  • Michalis Aivaliotis
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重度の僧帽弁逆流に伴う偏心性心筋細胞肥大のメカニズム

Mechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Severe Mitral Regurgitation.
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ルーマニア産アプリコット品種のカロテノイド、脂肪酸、および揮発性化合物の化学的アプローチ

Carotenoids, Fatty Acids, and Volatile Compounds in Apricot Cultivars from Romania-A Chemometric Approach.
  • Adela Pintea
  • Francisc Vasile Dulf
  • Andrea Bunea
  • Sonia Ancuța Socaci
  • Elena Andreea Pop
  • Vlăduț-Alexandru Opriță
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  • Giovanni Bartolomeo
  • Luigi Mondello
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ホスホ-HDAC6はパーキンソン病および非定型パーキンソン病においてタンパク質の集合体に集まる

Phospho-HDAC6 Gathers Into Protein Aggregates in Parkinson's Disease and Atypical Parkinsonisms.
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  • Mara De Leonardis
  • Gloria Gagliardi
  • Alessandra Maria Calogero
  • Milo Jarno Basellini
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  • Ilaria Costa
  • Francesca Cacciatore
  • Sonia Spinello
  • Manuela Bramerio
  • Roberto Cilia
  • Chiara Rolando
  • Giorgio Giaccone
  • Gianni Pezzoli
  • Graziella Cappelletti
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コンピュータ断層撮影カルシウムスコアリングと無症状のメキシコ人患者における臨床的心血管系リスクの関連性と再分類

Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients.
  • Aldo Javier Vázquez Mézquita
  • Michelle Claire Williams
  • Rafael Choza Chenhalls
  • Nancy Berenice Guzmán Martínez
  • Ana Patricia Chischistz Condey
  • Maria José Acosta Falomir
  • Marco Antonio Téliz Meneses
  • María Nayeli Vázquez Sánchez
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アジア系インド人糖尿病患者の「痩せた脂肪表現型」と部分的リポジストロフィーの間の共通の病態生理学的スレッド：末梢脂肪組織のトランスクリプトームエビデンス

The common pathophysiologic threads between Asian Indian diabetic's 'Thin Fat Phenotype' and partial lipodystrophy: the peripheral adipose tissue transcriptomic evidences.
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  • Pradeep Tiwari
  • Nitin Wahi
  • Anshul Kumar
  • Sandeep Kumar Mathur
  • Adipocyte.2020 Jan;9(1):253-263. doi: 10.1080/21623945.2020.1776082.

骨髄異形成症候群および高リスクの骨髄異形成症候群から進行した急性骨髄性白血病におけるデシタビンと低用量イダルビシンおよびシタラビンのエピジェネティックプライミング：前向き多施設単群試験

Epigenetic priming with decitabine followed by low dose idarubicin and cytarabine in acute myeloid leukemia evolving from myelodysplastic syndromes and higher-risk myelodysplastic syndromes: a prospective multicenter single-arm trial.
  • Xinping Zhou
  • Chen Mei
  • Jin Zhang
  • Ying Lu
  • Jianping Lan
  • Shengyun Lin
  • Yuefeng Zhang
  • Yuemin Kuang
  • Yanling Ren
  • Liya Ma
  • Juying Wei
  • Li Ye
  • Weilai Xu
  • Kongfei Li
  • Chenxi Lu
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大うつ病性障害および双極性障害を有する成人のうつ病症状、自殺念慮、機能障害に対するケタミンの反復静脈内投与の有効性。カナダ迅速治療センター・オブ・エクセレンスの結果

The effectiveness of repeated intravenous ketamine on depressive symptoms, suicidal ideation and functional disability in adults with major depressive disorder and bipolar disorder: Results from the Canadian Rapid Treatment Center of Excellence.
  • Roger S McIntyre
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  • Orly Lipsitz
  • Mehala Subramaniapillai
  • Hartej Gill
  • Flora Nasri
  • Amna Majeed
  • Leanna M W Lui
  • Olena Senyk
  • Lee Phan
  • Isabelle P Carvalho
  • Ashley Siegel
  • Rodrigo B Mansur
  • Elisa Brietzke
  • Kevin Kratiuk
  • Anil K Arekapudi
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  • Witold Szpejda
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オレイン酸とリノール酸は、好中球の細胞外トラップであるパンネキシン1依存性ATP放出とP2X1受容体活性化の放出を誘導する

Oleic and Linoleic Acids Induce the Release of Neutrophil Extracellular Traps Pannexin 1-Dependent ATP Release and P2X1 Receptor Activation.
  • Pablo Alarcón
  • Carolina Manosalva
  • John Quiroga
  • Isidora Belmar
  • Karina Álvarez
  • Gustavo Díaz
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  • Carlos Hermosilla
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  • Rafael A Burgos
  • María A Hidalgo
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レトロゾールを分散させたpHEMA/AAm-g-LDPE薬物放出系の調製。子宮内膜症治療のためのインビトロ放出速度論

Preparation of letrozole dispersed pHEMA/AAm-g-LDPE drug release system: In-vitro release kinetics for the treatment of endometriosis.
  • Akhtar Jahan Siddiqa
  • Nilesh Kumar Shrivastava
  • M E Ali Mohsin
  • Mustufa Haider Abidi
  • Tauqeer Ahmed Shaikh
  • Mohammed A El-Meligy
  • Colloids Surf B Biointerfaces.2019 Jul;179:445-452. S0927-7765(19)30237-1. doi: 10.1016/j.colsurfb.2019.04.014.Epub 2019-04-08.

以前の経尿道的前立腺手術が根治的前立腺摘除術後の健康関連QOLに与える影響。手術間の間隔は重要か？

Impact of previous transurethral prostate surgery on health-related quality of life after radical prostatectomy: Does the interval between surgeries matter?
  • Michael Chaloupka
  • Franka Figura
  • Philipp Weinhold
  • Friedrich Jokisch
  • Thilo Westhofen
  • Paulo Pfitzinger
  • Robert Bischoff
  • Giuseppe Magistro
  • Frank Strittmatter
  • Armin Becker
  • Steffen Ormanns
  • Boris Schlenker
  • Alexander Buchner
  • Christian G Stief
  • Alexander Kretschmer
  • World J Urol.2020 Jun;10.1007/s00345-020-03327-4. doi: 10.1007/s00345-020-03327-4.Epub 2020-06-29.

2'-O-メチルホスホロチオエートアンチセンスオリゴヌクレオチドの脳内投与によるマウス脳内自然免疫系の活性化について

Intracerebroventricular Administration of a 2'-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain.
  • Lodewijk J A Toonen
  • João Casaca-Carreira
  • Maria Pellisé-Tintoré
  • Hailiang Mei
  • Yasin Temel
  • Ali Jahanshahi
  • Willeke M C van Roon-Mom
  • Nucleic Acid Ther.2018 04;28(2):63-73. doi: 10.1089/nat.2017.0705.Epub 2018-03-22.

α-トコフェロールではなくγ-トコトリエノールによるpERKとc-JUNのアップレギュレーションが、前立腺癌細胞のアポトーシスに対する差異効果に不可欠であることがわかった

Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells.
  • Christine Moore
  • Victoria E Palau
  • Rashid Mahboob
  • Janet Lightner
  • William Stone
  • Koyamangalath Krishnan
  • BMC Cancer.2020 May;20(1):428. 10.1186/s12885-020-06947-6. doi: 10.1186/s12885-020-06947-6.Epub 2020-05-15.

地下水中の1,2,4,4-トリアゾール、N,N-ジメチルスルファミド、その他の低極性有機化合物の抽出と定量分析のための迅速かつ簡便なSPE-LC-MS/MS法

A fast and simple SPE-LC-MS/MS procedure for extraction and quantitative analysis of 1,2,4-triazole, N,N-dimethylsulfamide, and other small polar organic compounds in groundwater.
  • Ulla E Bollmann
  • Nora Badawi
  • Anal Bioanal Chem.2020 Jul;10.1007/s00216-020-02788-1. doi: 10.1007/s00216-020-02788-1.Epub 2020-07-09.

TRIP13干渉は、TTC5/p53経路と上皮間葉系転移関連遺伝子の発現を制御することで、甲状腺がん細胞の増殖と転移を抑制する

TRIP13 interference inhibits the proliferation and metastasis of thyroid cancer cells through regulating TTC5/p53 pathway and epithelial-mesenchymal transition related genes expression.
  • Leitao Yu
  • Yong Xiao
  • Xiang Zhou
  • Jun Wang
  • Sunqiang Chen
  • Tangyao Peng
  • Xingen Zhu
  • Biomed. Pharmacother..2019 Dec;120:109508. S0753-3322(19)34234-9. doi: 10.1016/j.biopha.2019.109508.Epub 2019-10-22.

継続的に肩関節全置換術後の肩の動きを監視する：最大仰角と仰角の90°以上に費やされた時間は、監視するための重要なメトリクスです

Continuously monitoring shoulder motion after total shoulder arthroplasty: maximum elevation and time spent above 90° of elevation are critical metrics to monitor.
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  • Michael T Torchia
  • John-Erik Bell
  • Douglas W Van Citters
  • J Shoulder Elbow Surg.2019 Aug;28(8):1505-1514. S1058-2746(19)30006-0. doi: 10.1016/j.jse.2019.01.003.Epub 2019-04-05.

非アルコール性脂肪性肝疾患患者における肝臓関連転帰に対するオメガ3脂肪酸の有効性と安全性。システマティックレビューおよびメタアナリシスのためのプロトコル

Efficacy and safety of omega-3 fatty acids on liver-related outcomes in patients with nonalcoholic fatty liver disease: A protocol for a systematic review and meta-analysis.
  • Xiao-Yan Shi
  • Si-Min Fan
  • Guo-Mei Shi
  • Jia Yao
  • Yang Gao
  • Yu-Guo Xia
  • Qiu Chen
  • Medicine (Baltimore).2020 Jun;99(24):e20624. 00005792-202006120-00055. doi: 10.1097/MD.0000000000020624.

中国北京のスクリーニング集団におけるヒトパピローマウイルス遺伝子型と前がん性子宮頸部病変の有病率：中国トップ3病院の結果分析、2009年～2019年

Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in Beijing, China: analysis of results from China's top 3 hospital, 2009-2019.
  • Yidi Liu
  • Qing Ang
  • Huan Wu
  • Jingjiang Xu
  • Defu Chen
  • Hongyou Zhao
  • Haolin Liu
  • Xianghuan Guo
  • Ying Gu
  • Haixia Qiu
  • Virol. J..2020 07;17(1):104. 10.1186/s12985-020-01383-1. doi: 10.1186/s12985-020-01383-1.Epub 2020-07-13.

3T3-L1 脂肪細胞を組換えカルシウム/カルモジュリン依存性プロテインキナーゼIV（CaMKIV）でin vitro処理すると、小胞体ストレスが制限され、mTOR/CREBシグナル伝達経路を介したオートファジーの阻害によりインスリン感受性が改善される

In vitro treatment of 3 T3-L1 adipocytes with recombinant Calcium/calmodulin-dependent Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTOR/CREB signaling pathway.
  • Jiali Liu
  • Ruihua Yang
  • Hao Meng
  • Ting Zhou
  • Qian He
  • BMC Endocr Disord.2020 Jul;20(1):104. 10.1186/s12902-020-00589-2. doi: 10.1186/s12902-020-00589-2.Epub 2020-07-13.

チロシルまたはイソロイシルtRNA合成酵素を標的としたフェニルトリアゾール機能化スルファミン酸阻害剤

Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase.
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  • Luping Pang
  • Charles-Alexandre Mattelaer
  • Manesh Nautiyal
  • Steff De Graef
  • Jef Rozenski
  • Sergei V Strelkov
  • Eveline Lescrinier
  • Stephen D Weeks
  • Arthur Van Aerschot
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ナトリウムチャネルダイマーをアンカップリングすることで、痛みに連動したNav1.7変異の表現型を回復させることができた

Uncoupling sodium channel dimers rescues the phenotype of a pain-linked Nav1.7 mutation.
  • Annika H Rühlmann
  • Jannis Körner
  • Ralf Hausmann
  • Nikolay Bebrivenski
  • Christian Neuhof
  • Silvia Detro-Dassen
  • Petra Hautvast
  • Carène A Benasolo
  • Jannis Meents
  • Jan-Philipp Machtens
  • Günther Schmalzing
  • Angelika Lampert
  • Br. J. Pharmacol..2020 Jul;doi: 10.1111/bph.15196.Epub 2020-07-14.

パンデミックコロナウイルス科の家族性感染症SARS-CoV-2、SARS-CoV、MERS-CoV、HCoVの複数検出のための迅速かつ感度の高い診断方法：ベトナムのPhan Chau Trinh大学とイタリアのBari大学"Aldo Moro"との間のトランスレーショナルリサーチと協力によるものです

Rapid and sensitive diagnostic procedure for multiple detection of pandemic Coronaviridae family members SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV: a translational research and cooperation between the Phan Chau Trinh University in Vietnam and University of Bari "Aldo Moro" in Italy.
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  • S T Pham
  • S Cantore
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神経上皮放射状グリア前駆細胞におけるCCL2/CCR2システム：視床下部ペプチドニューロンの胚発生に母体エタノールの刺激的な、性的に二型効果への関与

CCL2/CCR2 system in neuroepithelial radial glia progenitor cells: involvement in stimulatory, sexually dimorphic effects of maternal ethanol on embryonic development of hypothalamic peptide neurons.
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  • Olga Karatayev
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COVID-19パンデミックに向けた集学的研究の優先順位 -著者からの回答

Multidisciplinary research priorities for the COVID-19 pandemic - Authors' reply.
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ウサギの肺生検のための胸腔鏡下経横隔膜アプローチの実現可能性と有効性。無作為化研究

The feasibility and effectiveness of thoracoscopic transdiaphragmatic approach for lung biopsy in rabbits. A randomized study.
  • Monica Carolina Nery Wittmaack
  • Felipe Farias Pereira da Câmara Barros
  • Paloma do Espírito Santo Silva
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ニコチンアミドホスホリボシルトランスフェラーゼをマウス細胞に過剰発現させると、酸化的ストレスおよび小胞体ストレス誘発性早老化に対する保護効果がある

Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence.
  • Ardaning Nuriliani
  • Yasukazu Nakahata
  • Rezwana Ahmed
  • Fiqri D Khaidizar
  • Takaaki Matsui
  • Yasumasa Bessho
  • Genes Cells.2020 Jun;doi: 10.1111/gtc.12794.Epub 2020-06-13.

ノンコーディングスプライソーム遺伝子であるRNU4ATACに同定されたバリアントの臨床的解釈

Clinical interpretation of variants identified in RNU4ATAC, a non-coding spliceosomal gene.
  • Clara Benoit-Pilven
  • Alicia Besson
  • Audrey Putoux
  • Claire Benetollo
  • Clément Saccaro
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  • Gabriel Sala
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  • Sylvie Mazoyer
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エロンゲーター複合体の最大サブユニットをコードするCURLED LATER1は、イネの葉の発達とメリステム機能にユニークな役割を持っている

CURLED LATER1 encoding the largest subunit of the Elongator complex has a unique role in leaf development and meristem function in rice.
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  • Yukiko Yasui
  • Yoshihiro Ohmori
  • Wakana Tanaka
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  • Hisataka Numa
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  • Plant J..2020 Jul;doi: 10.1111/tpj.14925.Epub 2020-07-11.

ルタエカルピン誘導体Cpd-6cは、シスプラチン腎症における炎症を媒介する重要な酵素であるPDE4Bを標的とすることで、急性腎障害を緩和します

Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy.
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  • Juan Jin
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マウスにおけるASAP1の欠損は、FAK/SrcおよびAKTシグナルの調節障害を介して間葉系前駆細胞の脂肪原性および骨原性分化に障害を与える

Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling.
  • Caroline Schreiber
  • Supriya Saraswati
  • Shannon Harkins
  • Annette Gruber
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  • PLoS Genet..2019 06;15(6):e1008216. PGENETICS-D-19-00591. doi: 10.1371/journal.pgen.1008216.Epub 2019-06-27.

非活性抗生物質とバクテリオファージの相乗効果により、広範囲の薬剤耐性菌による再発性尿路感染症の治療に成功した

Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant .
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コロナウイルス病2019パンデミック期間中の中国の一般人口における精神的健康症状の有病率と関連する危険因子

Prevalence of and Risk Factors Associated With Mental Health Symptoms Among the General Population in China During the Coronavirus Disease 2019 Pandemic.
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  • Jian-Yu Que
  • Xiao-Lin Huang
  • Lin Liu
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  • Yi-Miao Gong
  • Kai Yuan
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  • Yan-Ping Bao
  • Lin Lu
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中体インタラクトームから明らかになったPP1ホスファターゼのサイトカインにおける意外な役割

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis.
  • Luisa Capalbo
  • Zuni I Bassi
  • Marco Geymonat
  • Sofia Todesca
  • Liviu Copoiu
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  • Giuliano Callaini
  • Maria Giovanna Riparbelli
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  • Enrico Ferrero
  • Sally Wheatley
  • Max E Douglas
  • Masanori Mishima
  • Pier Paolo D'Avino
  • Nat Commun.2019 10;10(1):4513. 10.1038/s41467-019-12507-9. doi: 10.1038/s41467-019-12507-9.Epub 2019-10-04.

ミトコンドリア脳筋症、乳酸アシドーシス、脳卒中様エピソード（MELAS）患者における発作期および寛解期における自発脳活動の変化：脳卒中様病変を超えて

Altered spontaneous brain activity at attack and remission stages in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS): beyond stroke-like lesions.
  • Rong Wang
  • Yuxin Li
  • Jie Lin
  • Chong Sun
  • Ne Chen
  • Weixingzi Xu
  • Bin Hu
  • Xueling Liu
  • Daoying Geng
  • Liqin Yang
  • Mitochondrion.2020 Jul;S1567-7249(20)30162-8. doi: 10.1016/j.mito.2020.07.002.Epub 2020-07-14.

加水分解性タンニンによる黄色ブドウ球菌α-ヘモリシンと赤血球膜との相互作用の阻害：構造関連活性研究

Inhibition of interaction between Staphylococcus aureus α-hemolysin and erythrocytes membrane by hydrolysable tannins: structure-related activity study.
  • Ewa Olchowik-Grabarek
  • Szymon Sekowski
  • Maciej Bitiucki
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  • Sci Rep.2020 Jul;10(1):11168. 10.1038/s41598-020-68030-1. doi: 10.1038/s41598-020-68030-1.Epub 2020-07-07.

暑い海王星の砂漠にある惑星の残骸コア

A remnant planetary core in the hot-Neptune desert.
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サトウキビに寄生する（Lepidoptera: Crambidae）、その卵およびサトウキビに寄生するアリの被害に及ぼす作物残渣管理の影響

Effect of crop residue management on damage by (Lepidoptera: Crambidae), its egg parasitoids and the ants associated with sugarcane.
  • María L Del P Pérez
  • Marcos G Isas
  • Francois R Goebel
  • Ma Marta Ayup
  • Agustín E Padilla
  • Analía R Salvatore
  • Gerardo Gastaminza
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減衰全反射フーリエ変換赤外（ATR-FTIR）分光法によるインタクトな細胞外小胞の無試薬全タンパク質定量

Reagent-free total protein quantification of intact extracellular vesicles by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy.
  • Veronika Szentirmai
  • András Wacha
  • Csaba Németh
  • Diána Kitka
  • Anita Rácz
  • Károly Héberger
  • Judith Mihály
  • Zoltán Varga
  • Anal Bioanal Chem.2020 Jul;412(19):4619-4628. 10.1007/s00216-020-02711-8. doi: 10.1007/s00216-020-02711-8.Epub 2020-05-29.

スーダンから中国に輸入されたフェネックフォックスに生息する拡張スペクトラム-β-ラクタマーゼ産生大腸菌の出現と比較ゲノミクス解析

Emergence and Comparative Genomics Analysis of Extended-Spectrum-β-Lactamase-Producing Escherichia coli Carrying in Fennec Fox Imported from Sudan to China.
  • Chunyan Feng
  • Peipei Wen
  • Hao Xu
  • Xiaohui Chi
  • Shuang Li
  • Xiao Yu
  • Xiangmei Lin
  • Shaoqiang Wu
  • Beiwen Zheng
  • mSphere.2019 11;4(6). e00732-19. doi: 10.1128/mSphere.00732-19.Epub 2019-11-20.

一過性受容体電位 バニロイドチャネルは、NADPHオキシダーゼ4を介した酸化還元シグナルを調節することで、線維芽細胞の分化や気道リモデリングを制御しています

Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4.
  • Nosayba Al-Azzam
  • Lakshminarayan Reddy Teegala
  • Sabita Pokhrel
  • Samrawit Ghebreigziabher
  • Tatiana Chachkovskyy
  • Sathwika Thodeti
  • Ignacio Gavilanes
  • Kayla Covington
  • Charles K Thodeti
  • Sailaja Paruchuri
  • Sci Rep.2020 Jun;10(1):9827. 10.1038/s41598-020-66617-2. doi: 10.1038/s41598-020-66617-2.Epub 2020-06-17.

新しい選択的オートファジー受容体CCDC50は、ウイルス感染中に分解のためにK63ポリユビキチン化活性化されたRIG-I/MDA5を送達する

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection.
  • Panpan Hou
  • Kongxiang Yang
  • Penghui Jia
  • Lan Liu
  • Yuxin Lin
  • Zibo Li
  • Jun Li
  • Shuliang Chen
  • Shuting Guo
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  • Junyu Wu
  • Hong Peng
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  • Cell Res..2020 Jul;10.1038/s41422-020-0362-1. doi: 10.1038/s41422-020-0362-1.Epub 2020-07-01.

6'-β-フルオロ-ホモアリステロマイシンおよび6'-フルオロ-ホモネプラノシンAは、ウイルス非構造タンパク質1に対する直接的な効果を介してチクングニヤウイルス複製の強力な阻害剤である

6'-β-Fluoro-Homoaristeromycin and 6'-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 1.
  • Kristina Kovacikova
  • Bas M Morren
  • Ali Tas
  • Irina C Albulescu
  • Robin van Rijswijk
  • Dnyandev B Jarhad
  • Young Sup Shin
  • Min Hwan Jang
  • Gyudong Kim
  • Hyuk Woo Lee
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  • Eric J Snijder
  • Martijn J van Hemert
  • Antimicrob. Agents Chemother..2020 03;64(4). e02532-19. doi: 10.1128/AAC.02532-19.Epub 2020-03-24.

周期的電界-フロー分画を用いた差動遠心によって分離されたヒト神経膠芽腫と正常血漿由来の細胞外小胞の特性評価

Characterization of Human Glioblastoma versus Normal Plasma-Derived Extracellular Vesicles Preisolated by Differential Centrifugation Using Cyclical Electrical Field-Flow Fractionation.
  • Farhad Shiri
  • Bruce K Gale
  • Himanshu Sant
  • Gina T Bardi
  • Joshua L Hood
  • Kevin E Petersen
  • Anal. Chem..2020 Jul;doi: 10.1021/acs.analchem.0c01373.Epub 2020-07-07.

エチオピア、アムハラ州北シェワ地区の障害者における家族計画の知識、態度、実践のレベルと関連因子

Level of knowledge, attitude, and practice of family planning and associated factors among disabled persons, north-shewa zone, Amhara regional state, Ethiopia.
  • Alemayehu Gonie Mekonnen
  • Alebachew Demelash Bayleyegn
  • Yared Asmare Aynalem
  • Tigist Demssew Adane
  • Mikyas Arega Muluneh
  • Meaza Asefa
  • Contracept Reprod Med.2020;5:8. 111. doi: 10.1186/s40834-020-00111-y.Epub 2020-07-01.

カロリー制限肥満ラットの肥満治療におけるローヤルゼリーとトコトリエノールリッチフラクションの効果：白色脂肪の褐変特性と発熱能に着目した

Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity.
  • Naimeh Mesri Alamdari
  • Pardis Irandoost
  • Neda Roshanravan
  • Mohammadreza Vafa
  • Mohammad Asghari Jafarabadi
  • Shahriar Alipour
  • Leila Roshangar
  • Mohammadreza Alivand
  • Farnaz Farsi
  • Farzad Shidfar
  • Nutr Metab (Lond).2020;17:42. 458. doi: 10.1186/s12986-020-00458-8.Epub 2020-06-01.

障害者の対象となる雇用に関する医学的・法的考察と産業医学的問題：規制の見直し、現在の社会的・医学的運用ガイドライン、および現在の適用現象

[Medico-legal considerations and occupational medicine issues regarding the targeted employment of disabled persons: regulatory review, current social and medical operational guidelines and current application phenomena].
  • Michele Sammicheli
  • Marcella Scaglione
  • G Ital Med Lav Ergon.2020 Mar;42(1):60-67. GIMLEv42i9.

チクングニヤウイルスとマヤロウイルスの共感染後の血清学的調査のロバスト性

Robustness of Serologic Investigations for Chikungunya and Mayaro Viruses following Coemergence.
  • Carlo Fischer
  • Fernando Bozza
  • Xiomara Jeanleny Merino Merino
  • Celia Pedroso
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  • Alvaro Schwalb
  • Xavier de Lamballerie
  • Eduardo Martins Netto
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  • Carlos Brites
  • Eduardo Gotuzzo
  • Michael Talledo
  • Jan Felix Drexler
  • mSphere.2020 02;5(1). e00915-19. doi: 10.1128/mSphere.00915-19.Epub 2020-02-05.

感覚障害者がプライマリ・ヘルスケアでケアするためのコミュニケーションの障壁とファシリテーター：マルチレベル研究

Barriers to and facilitators of communication to care for people with sensory disabilities in primary health care: a multilevel study.
  • Aline Macarevich Condessa
  • Jessye Melgarejo do Amaral Giordani
  • Matheus Neves
  • Fernando Neves Hugo
  • Juliana Balbinot Hilgert
  • Rev Bras Epidemiol.2020;23:e200074. S1415-790X2020000100460. doi: 10.1590/1980-549720200074.Epub 2020-07-06.

ヘルシーママ II トライアルの根拠、デザイン、ベースラインデータ。産後うつの予防のための運動とウェルネス介入の有効性を検討する無作為化試験

Rationale, design, and baseline data for the Healthy Mom II Trial: A randomized trial examining the efficacy of exercise and wellness interventions for the prevention of postpartum depression.
  • Beth A Lewis
  • Katie Schuver
  • Shira Dunsiger
  • Lauren Samson
  • Amanda L Frayeh
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  • Joseph T Ciccolo
  • Melissa D Avery
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多発性硬化症患者のコホートにおける社会的距離の維持および個人用保護具の使用と SARS-CoV-2 感染のリスク

Adherence to social distancing and use of personal protective equipment and the risk of SARS-CoV-2 infection in a cohort of patients with multiple sclerosis.
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  • Ponzano M
  • Nicoletti Cg
  • Cecchi G
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  • Mataluni G
  • Mercuri Nb
  • Sormani Mp
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アルツハイマー病のストレプトゾトシン誘発マウスモデルにおけるロシグリタゾン包埋ナノキャリアシステムの神経保護の可能性を探る

Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease.
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  • Violina Kakoty
  • Sandhya Marathe
  • Deepak Chitkara
  • Rajeev Taliyan
  • Neurotox Res.2020 Jul;10.1007/s12640-020-00258-1. doi: 10.1007/s12640-020-00258-1.Epub 2020-07-18.

腫瘍関連抗原を認識する少数のT細胞は、自己HLAで提示された腫瘍関連抗原を認識することで、抗腫瘍反応を誘発することができる

A Minority of T Cells Recognizing Tumor-Associated Antigens Presented in Self-HLA Can Provoke Anti-Tumor Reactivity.
  • Marthe C J Roex
  • Lois Hageman
  • Sabrina Veld
  • H M Esther van Egmond
  • Conny Hoogstraten
  • Christian Stemberger
  • Lothar Germeroth
  • Hermann Einsele
  • J H Frederik Falkenburg
  • Inge Jedema
  • Blood.2020 Jun;blood.2019004443. doi: 10.1182/blood.2019004443.Epub 2020-06-01.

トルフェナム酸は卵巣がん細胞の増殖を抑制し、特異性タンパク質転写因子を抑制することでc-Metやサバイビンの発現を低下させます

Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors.
  • Riyaz Basha
  • Susan B Ingersoll
  • Umesh T Sankpal
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牛未経産牛の妊娠初期における末梢血単核細胞および多形核白血球におけるI型インターフェロン受容体およびインターフェロンτ刺激遺伝子の発現

Type I interferon receptors and interferon-τ-stimulated genes in peripheral blood mononuclear cells and polymorphonuclear leucocytes during early pregnancy in beef heifers.
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社内シロップ製剤中の逆相hplcによるデキストロメトルファン臭化水素酸塩とデスロラタジンの同時多変量定量法の開発とバリデーションのためのボックスベーンケンデザインアシストメソッドの開発とバリデーション

A multivariate quantification of box behnken design assisted method development and validation of dextromethorphan hydrobromide and desloratadine simultaneously by reverse phase hplc in in-house syrup formulation.
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COVID-19を識別するための鼻閉塞を伴わない自己申告による嗅覚喪失。多施設共同CORANOSMIAコホート研究

Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter CORANOSMIA cohort study.
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Trp53欠損マウスにおける高エネルギー放射線および低エネルギー放射線によって誘発される腫瘍の変異シグネチャー

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice.
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長期人工呼吸器の使用が健康関連の生活の質と神経筋疾患の子どもとその家族のメンタルヘルスに与える影響：視点の見直しが必要か？

The impact of long-term ventilator-use on health-related quality of life and the mental health of children with neuromuscular diseases and their families: need for a revised perspective?
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COVID-19でより難易度の高いラピッドレビュー手法。8つの知識合成ステップに焦点を当てた解説

Rapid review methods more challenging during COVID-19: Commentary with a focus on 8 knowledge synthesis steps.
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トルコにおける幼児期の発達と発達障害への対応：発達小児科ユニットのトレーニングプログラム

Addressing early childhood development and developmental difficulties in Turkey: a training programfor developmental pediatrics units.
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思春期前のシクロホスファミド曝露による精子形成、ステロイド形成、精巣構造のミューティレーションがSDラットで認められた。代替ハーブバイアグラからの保護

Pre-pubertal cyclophosphamide exposure-induced mutilation in spermatogenesis, steroidogenesis and testicular architecture in SD rat: Protection from an alternative herbal viagra.
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  • Durga Prasad Beda
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過体重/肥満の青年期のインスリン抵抗性に対する高タンパク/低血糖指標食の効果-PREVIEW無作為化臨床試験

Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity-A PREVIEW randomized clinical trial.
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SNHG20のノックダウンは、miR-2467-3p/E2F3を制御することで、増殖・移行・浸潤を抑制し、アポトーシスを誘導することで、非小細胞肺癌の発生を抑制することが明らかになった

Knockdown SNHG20 Suppresses Nonsmall Cell Lung Cancer Development by Repressing Proliferation, Migration and Invasion, and Inducing Apoptosis by Regulating miR-2467-3p/E2F3.
  • Hang Chen
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広範囲な病変の偏析ががんゲノムの進化を形作る

Pervasive lesion segregation shapes cancer genome evolution.
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経皮的冠動脈インターベンション後の急性冠症候群患者におけるマルチジーン薬理遺伝学的検査の費用対効果．

Cost-Effectiveness of Multigene Pharmacogenetic Testing in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention.
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トリプルネガティブ乳癌に対する MR/蛍光イメージングおよび強化された光力学的治療のためのフィブロネクチン標的化およびカテプシン B 活性化可能な治療法ナノプローブ

Fibronectin-Targeting and Cathepsin B-Activatable Theranostic Nanoprobe for MR/Fluorescence Imaging and Enhanced Photodynamic Therapy for Triple Negative Breast Cancer.
  • Yanshu Wang
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  • ACS Appl Mater Interfaces.2020 Jul;doi: 10.1021/acsami.0c10397.Epub 2020-07-20.

BRCA 変異キャリアにおけるラジオミクスと機械学習を用いた MRI 上のセンチ以下の増強乳房腫瘤の特徴付けの改善

Improved characterization of sub-centimeter enhancing breast masses on MRI with radiomics and machine learning in BRCA mutation carriers.
  • Roberto Lo Gullo
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  • Carolina Rossi Saccarelli
  • Almir Bitencourt
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  • Katja Pinker
  • Eur Radiol.2020 Jun;10.1007/s00330-020-06991-7. doi: 10.1007/s00330-020-06991-7.Epub 2020-06-27.

リン酸ナトリウムの経口負荷が非正常および高カルシウム血症の結石形成患者における副甲状腺ホルモンおよび線維芽細胞増殖因子23の分泌に及ぼす影響

The effect of an oral sodium phosphate load on parathyroid hormone and fibroblast growth factor 23 secretion in normo- and hypercalciuric stone-forming patients.
  • Tomasz Irzyniec
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非小細胞肺がんに対するユニポータルビデオ支援胸部外科的葉切除術後の胸膜ドレナージ量の予測因子：単施設レトロスペクティブ研究

Predictive factors for pleural drainage volume after uniportal video-assisted thoracic surgery lobectomy for non-small cell lung cancer: a single-institution retrospective study.
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血液脳関門における差異発現は、AAV-PHP.B.の菌株特異的中枢神経系トランスダクションプロファイルに責任がある

Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B.
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MnO粉末による低線量放射線被曝はラットの精巣と前立腺の遺伝子発現を変化させる

Low-Dose Radiation Exposure with MnO Powder Changes Gene Expressions in the Testes and the Prostate in Rats.
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  • Gaukhar Amantayeva
  • Nailya Chaizhunussova
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  • Bakhyt Ruslanova
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進化的解析により、イネL-ミオイノシトール1リン酸合成酵素の触媒活性に不可欠な2つのリジン残基を含む保存されたペンタペプチド配列が同定された

An evolutionary analysis identifies a conserved pentapeptide stretch containing the two essential lysine residues for rice L-myo-inositol 1-phosphate synthase catalytic activity.
  • Papri Basak
  • Susmita Maitra-Majee
  • Jayanta Kumar Das
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  • Shubhra Ghosh Dastidar
  • Pabitra Pal Choudhury
  • Arun Lahiri Majumder
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選択的消化管除染を受けた集中治療患者と健常者の腸内細菌叢とレジストームプロファイリングの比較

Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
  • Elena Buelow
  • Teresita D J Bello González
  • Susana Fuentes
  • Wouter A A de Steenhuijsen Piters
  • Leo Lahti
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  • Eline A M Majoor
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  • Maaike S M van Mourik
  • Evelien A N Oostdijk
  • Rob J L Willems
  • Marc J M Bonten
  • Mark W J van Passel
  • Hauke Smidt
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  • Microbiome.2017 08;5(1):88. 10.1186/s40168-017-0309-z. doi: 10.1186/s40168-017-0309-z.Epub 2017-08-14.

肥大から不全への移行期における左室応答は、大動脈弁逆流症マウスにおけるAkt、β-アレスチン-2、CaMKIIの異なる役割を再現している

Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation.
  • Jian Wu
  • Jieyun You
  • Xiaoyan Wang
  • Shijun Wang
  • Jiayuan Huang
  • Qihai Xie
  • Baoyong Gong
  • Zhiwen Ding
  • Yong Ye
  • Cong Wang
  • Le Kang
  • Ran Xu
  • Yang Li
  • Ruizhen Chen
  • Aijun Sun
  • Xiangdong Yang
  • Hong Jiang
  • Fenghua Yang
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  • Junbo Ge
  • Yunzeng Zou
  • Ann Transl Med.2020 Mar;8(5):219. atm-08-05-219. doi: 10.21037/atm.2020.01.51.

食事の全血DNAメチル化シグネチャーは、心血管疾患のリスク因子と全原因死亡率と関連している

Whole Blood DNA Methylation Signatures of Diet Are Associated with Cardiovascular Disease Risk Factors and All-cause Mortality.
  • Jiantao Ma
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  • Colleen M Sitlani
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  • Janie Corley
  • Ian J Deary
  • Yan Zhang
  • Ben Schöttker
  • Hermann Brenner
  • Maura E Walker
  • Shumao Ye
  • Steve Nguyen
  • Jim Pankow
  • Ellen W Demerath
  • Yinan Zheng
  • Lifang Hou
  • Liming Liang
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  • Myriam Fornage
  • Trudy Voortman
  • Daniel Levy
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Sm遺伝子のゲノムワイドな同定と発現解析により、Dimocarpus longan Lourの初期体性胚発生に関与していることが明らかになった

Genome-wide identification and expression analyses of Sm genes reveal their involvement in early somatic embryogenesis in Dimocarpus longan Lour.
  • Xue Li
  • Yan Chen
  • Shuting Zhang
  • Liyao Su
  • Xiaoping Xu
  • Xiaohui Chen
  • Zhongxiong Lai
  • Yuling Lin
  • PLoS ONE.2020;15(4):e0230795. PONE-D-20-00319. doi: 10.1371/journal.pone.0230795.Epub 2020-04-03.

Bialowieza原始原生林のバイソンにおける肝臓フルークのミトコンドリアDNAハプロタイプ解析により、家畜が感染源である可能性が示唆された

Mitochondrial DNA haplotype analysis of liver fluke in bison from Bialowieza Primaeval Forest indicates domestic cattle as the likely source of infection.
  • Stephen M Walker
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  • Monika Kozak
  • Halina Wedrychowicz
  • Denitsa Teofanova
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  • Vet. Parasitol..2013 Jan;191(1-2):161-4. S0304-4017(12)00415-3. doi: 10.1016/j.vetpar.2012.08.002.Epub 2012-08-09.

アンドロゲンは、思春期の雄ラットのCA1海馬下野の錐体神経細胞の内在性可塑性のダイナミクスに影響を与える

Androgen Affects the Dynamics of Intrinsic Plasticity of Pyramidal Neurons in the CA1 Hippocampal Subfield in Adolescent Male Rats.
  • Md Nabiul Islam
  • Yuya Sakimoto
  • Mir Rubayet Jahan
  • Mako Ishida
  • Abu Md Mamun Tarif
  • Kanako Nozaki
  • Koh-Hei Masumoto
  • Akie Yanai
  • Dai Mitsushima
  • Koh Shinoda
  • Neuroscience.2020 Aug;440:15-29. S0306-4522(20)30319-5. doi: 10.1016/j.neuroscience.2020.05.025.Epub 2020-05-23.

子豚（離乳）、肥育用鶏、産卵用に飼育された鶏、肥育用七面鳥、繁殖用に飼育された七面鳥の飼料添加物としての ECONASEXT (endo-1,4-β-キシラナーゼ) の認可更新申請の評価

Assessment of the application for renewal of authorisation of ECONASEXT (endo-1,4-β-xylanase) as a feed additive for piglets (weaned), chickens for fattening, chickens reared for laying, turkeys for fattening and turkeys reared for breeding.
  • Vasileios Bampidis
  • Giovanna Azimonti
  • Maria de Lourdes Bastos
  • Henrik Christensen
  • Birgit Dusemund
  • Maryline Kouba
  • Mojca Kos Durjava
  • Marta López-Alonso
  • Secundino López Puente
  • Francesca Marcon
  • Baltasar Mayo
  • Alena Pechová
  • Mariana Petkova
  • Fernando Ramos
  • Yolanda Sanz
  • Roberto Villa
  • Ruud Woutersen
  • Pier Sandro Cocconcelli
  • Boet Glandorf
  • Lieve Herman
  • Miguel Maradona Prieto
  • Maria Saarela
  • Jaume Galobart
  • Lucilla Gregoretti
  • Matteo Lorenzo Innocenti
  • Gloria López Gálvez
  • Konstantinos Sofianidis
  • Maria Vittoria Vettori
  • Rosella Brozzi
  • EFSA J.2019 Nov;17(11):e05880. EFS25880. doi: 10.2903/j.efsa.2019.5880.Epub 2019-11-07.

茶ポリフェノールは、海馬ニューロンにおけるBDNF-TrkB/AktおよびErk1/2シグナル伝達軸を調節することにより、スタウロスポリン誘発細胞毒性およびアポトーシスを減衰させる

Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.
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  • Teng-Teng Ren
  • Rongfeng Lan
  • Xiao-Yan Qin
  • IBRO Rep.2020 Jun;8:115-121. S2451-8301(20)30012-1. doi: 10.1016/j.ibror.2020.04.002.Epub 2020-04-19.

機械学習と知識工学を用いた電子カルテにおける希少疾患の検出急性肝ポルフィリン症のケーススタディ

Detecting rare diseases in electronic health records using machine learning and knowledge engineering: Case study of acute hepatic porphyria.
  • Aaron M Cohen
  • Steven Chamberlin
  • Thomas Deloughery
  • Michelle Nguyen
  • Steven Bedrick
  • Stephen Meninger
  • John J Ko
  • Jigar J Amin
  • Alex J Wei
  • William Hersh
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急性心筋梗塞を有するブタの再灌流に先立って同種心筋細胞の冠動脈内投与は、梗塞サイズを減少させ、心臓リモデリングの悪化を抑制する

Intracoronary Administration of Allogeneic Cardiosphere-Derived Cells Immediately Prior to Reperfusion in Pigs With Acute Myocardial Infarction Reduces Infarct Size and Attenuates Adverse Cardiac Remodeling.
  • Vasileios Sousonis
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  • Argirios Ntalianis
  • Ioannis Nanas
  • Christos Kontogiannis
  • Dionysios Aravantinos
  • Chris Kapelios
  • Lampros Katsaros
  • Maria Nana
  • Dimitrios Sampaziotis
  • Despina Sanoudou
  • Apostolos Papalois
  • Konstantinos Malliaras
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X線結晶学、IR/Raman分光学、周期的DFTを組み合わせた新規多成分制吐剤結晶形態の研究。マレイン酸カルベンダジムを例にして

Combined X-ray Crystallographic, IR/Raman Spectroscopic, and Periodic DFT Investigations of New Multicomponent Crystalline Forms of Anthelmintic Drugs: A Case Study of Carbendazim Maleate.
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  • Molecules.2020 May;25(10). E2386. doi: 10.3390/molecules25102386.Epub 2020-05-21.

発作性夜行性ヘモグロビン尿症：プレドニゾンにするか、プレドニゾンにしないか--以前に15年間ステロイドで治療された患者の症例報告とエクリズマブでの有意な反応

Paroxysmal nocturnal haemoglobinuria: to prednisone or not to prednisone?--a case report of a patient previously treated with steroids for 15 yrs and significant response on eculizumab.
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  • Ferras Alashkar
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局所的な冠動脈狭窄を有する豚モデルの経皮的作製には、3Dプリント冠動脈インプラントが有効である

3D-Printed Coronary Implants Are Effective for Percutaneous Creation of Swine Models with Focal Coronary Stenosis.
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  • Jiaxin Shao
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  • Jesse W Currier
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  • Rohan Dharmakumar
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  • J Cardiovasc Transl Res.2020 May;10.1007/s12265-020-10018-3. doi: 10.1007/s12265-020-10018-3.Epub 2020-05-11.

HBV感染細胞から分泌される細胞外小胞は、流体力学的HBVトランスフェクションマウスモデルにおけるHBVの持続性を調節する

Extracellular vesicles secreted by HBV-infected cells modulate HBV persistence in hydrodynamic HBV transfection mouse model.
  • Masatoshi Kakizaki
  • Yuichiro Yamamoto
  • Motoyuki Otsuka
  • Kouichi Kitamura
  • Masatoshi Ito
  • Hideki Derek Kawai
  • Masamichi Muramatsu
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低所得国での感染：抗菌薬耐性、ゲノムの多様性、リスク因子

carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors.
  • Bich-Tram Huynh
  • Virginie Passet
  • Andriniaina Rakotondrasoa
  • Thierno Diallo
  • Alexandra Kerleguer
  • Melanie Hennart
  • Agathe De Lauzanne
  • Perlinot Herindrainy
  • Abdoulaye Seck
  • Raymond Bercion
  • Laurence Borand
  • Maria Pardos de la Gandara
  • Elisabeth Delarocque-Astagneau
  • Didier Guillemot
  • Muriel Vray
  • Benoit Garin
  • Jean-Marc Collard
  • Carla Rodrigues
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  • Gut Microbes.2020 Sep;11(5):1287-1299. doi: 10.1080/19490976.2020.1748257.Epub 2020-05-13.

認知的に健康な高齢者における神経心理学的状態評価（RBANS）パフォーマンスのための反復可能なバッテリーに対する心血管リスク因子の影響

The Effects of Cardiovascular Risk Factors on Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Performance in Cognitively Healthy Older Adults.
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  • Daniel Weitzner
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過去10年間のドイツ東部地域における血友病治療の発展 Kompetenznetz Hmorrhagische Diathese Ost (KHDO)における

Development of Haemophilia Treatment in the Eastern Part of Germany over the Last Decade in the Kompetenznetz Hämorrhagische Diathese Ost (KHDO).
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  • Kristina Schilling
  • Robert Klamroth
  • Karim Kentouche
  • Volker Aumann
  • Lars Fischer
  • Susanne Holzhauer
  • Harry Sirb
  • Ute Scholz
  • Karolin Trautmann
  • Ines Halm-Heinrich
  • Beate Krammer-Steiner
  • Jürgen Koscielny
  • Ute Kreibich
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  • Matthias Tregel
  • Ralf Knöfler
  • Christian Pfrepper
  • Hamostaseologie.2020 Feb;40(1):119-127. doi: 10.1055/s-0039-3399493.Epub 2019-11-11.

D-フルクトースのアゾフェニルボロン酸系比色センサー：プロトン性溶媒を挿入したアゾフェニルボロン酸が大きな色変化の鍵を握っている

o-Azophenylboronic Acid-based Colorimetric Sensors for D-Fructose: o-Azophenylboronic Acids with Inserted Protic Solvent are the Key Species for a Large Color Change.
  • Yota Suzuki
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  • Keiji Ohno
  • Takashi Fujihara
  • Tomoaki Sugaya
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リスペリドン血漿中濃度は，自閉症スペクトラム障害の小児および青年における副作用および有効性と関連している．

Risperidone plasma concentrations are associated with side-effects and effectiveness in children and adolescents with autism spectrum disorder.
  • Sanne Maartje Kloosterboer
  • Brenda C M de Winter
  • Catrien G Reichart
  • Mirjam E J Kouijzer
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  • Emma van Daalen
  • Wietske A Ester
  • Rob Rieken
  • Gwen C Dieleman
  • Daphne van Altena
  • Beatrijs Bartelds
  • Ron H N van Schaik
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  • Teun van Gelder
  • Bram Dierckx
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  • Br J Clin Pharmacol.2020 Jul;doi: 10.1111/bcp.14465.Epub 2020-07-09.

胆汁酸およびリゾリン脂質のアンターゲットプロファイリングは、肥満の非糖尿病性臨床コホートにおける血糖アウトカムに関連する脂質シグネチャを特定します

Untargeted Profiling of Bile Acids and Lysophospholipids Identifies the Lipid Signature Associated with Glycemic Outcome in an Obese Non-Diabetic Clinical Cohort.
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  • Armand Valsesia
  • Mojgan Masoodi
  • Biomolecules.2020 Jul;10(7). E1049. doi: 10.3390/biom10071049.Epub 2020-07-15.

副鼻腔逆さ乳頭腫におけるヒトパピローマウイルス感染症の高有病率：単施設の患者コホート

High prevalence of human papillomavirus infection in sinonasal inverted papilloma: a single-institution cohort of patients.
  • Giuliana Frasson
  • Sonia Cesaro
  • Diego Cazzador
  • Giulia Traverso
  • Enzo Emanuelli
  • Daniele Borsetto
  • Giada Munari
  • Roberta Salmaso
  • Alessandro Martini
  • Paolo Boscolo-Rizzo
  • Massimo Rugge
  • Int Forum Allergy Rhinol.2020 May;10(5):629-635. doi: 10.1002/alr.22539.Epub 2020-02-27.

長期ERTを施行したゴーシェ病患者における血小板機能異常-出血困難時の評価への示唆

Platelet function defects in patients with Gaucher disease on long term ERT- implications for evaluation at bleeding challenges.
  • Veroniki Komninaka
  • Konstantina Repa
  • Theodoros Marinakis
  • Abraham Pouliakis
  • Theodora Koutsouri
  • Dimitrios Tsokanas
  • Pagona Flevary
  • Ersi Voskaridou
  • Marianna Politou
  • Blood Cells Mol. Dis..2020 02;80:102371. S1079-9796(19)30245-1. doi: 10.1016/j.bcmd.2019.102371.Epub 2019-10-18.

グルコセレブロシダーゼ活性は病的なα-シヌクレイン刺激に対する神経細胞の感受性を調節する

Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.
  • Michael X Henderson
  • Samantha Sedor
  • Ian McGeary
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  • Virginia M Y Lee
  • Neuron.2020 03;105(5):822-836.e7. S0896-6273(19)31046-3. doi: 10.1016/j.neuron.2019.12.004.Epub 2019-12-30.

サトウキビ由来ポリフェノール混合飼料は、周期的な熱曝露がブロイラーニワトリの成長性能、血液ガス状態、肉質に及ぼす負の影響を低減する

A Dietary Sugarcane-Derived Polyphenol Mix Reduces the Negative Effects of Cyclic Heat Exposure on Growth Performance, Blood Gas Status, and Meat Quality in Broiler Chickens.
  • Majid Shakeri
  • Jeremy J Cottrell
  • Stuart Wilkinson
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  • Hafiz A R Suleria
  • Robyn D Warner
  • Frank R Dunshea
  • Animals (Basel).2020 Jul;10(7). E1158. doi: 10.3390/ani10071158.Epub 2020-07-08.

晩期うつ病症状に関連する脳内マイクロRNAは、認知軌跡や認知症にも関連している

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia.
  • Thomas S Wingo
  • Jingjing Yang
  • Wen Fan
  • Se Min Canon
  • Ekaterina Sergeevna Gerasimov
  • Adriana Lori
  • Benjamin Logsdon
  • Bing Yao
  • Nicholas T Seyfried
  • James J Lah
  • Allan I Levey
  • Patricia A Boyle
  • Julia A Schneider
  • Philip L De Jager
  • David A Bennett
  • Aliza P Wingo
  • NPJ Genom Med.2020;5:6. 113. doi: 10.1038/s41525-019-0113-8.Epub 2020-02-06.

抗がん剤フルタミド及びその変換生成物の病院排水からの除去のための太陽光フェントンと吸着プロセスの組み合わせ

Combination of solar photo-Fenton and adsorption process for removal of the anticancer drug Flutamide and its transformation products from hospital wastewater.
  • Alexandre Della-Flora
  • Marcelo L Wilde
  • Pascal S Thue
  • Diana Lima
  • Eder C Lima
  • Carla Sirtori
  • J. Hazard. Mater..2020 Sep;396:122699. S0304-3894(20)30688-9. doi: 10.1016/j.jhazmat.2020.122699.Epub 2020-04-14.

心不全で駆出率が保存された患者における植込み型ループ記録による心室性頻脈性不整脈の検出．VIP-HF試験

Ventricular Tachyarrhythmia Detection by Implantable Loop Recording in Patients with Heart Failure and Preserved Ejection Fraction: The VIP-HF study.
  • Dirk J van Veldhuisen
  • Gijs van Woerden
  • Thomas M Gorter
  • Vanessa P M van Empel
  • Olivier C Manintveld
  • Robert G Tieleman
  • Alexander H Maass
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  • B Daan Westenbrink
  • Isabelle C van Gelder
  • Michiel Rienstra
  • Eur. J. Heart Fail..2020 Jul;doi: 10.1002/ejhf.1970.Epub 2020-07-19.

トシル化大環状ピリジノファンとの超分子相互作用によるエキゾチックトリブロミド(Br)アニオンの安定化.セレンディピタスケース

Stabilisation of Exotic Tribromide (Br) Anions via Supramolecular Interaction with A Tosylated Macrocyclic Pyridinophane. A Serendipitous Case.
  • Álvaro Martínez-Camarena
  • Matteo Savastano
  • Carla Bazzicalupi
  • Antonio Bianchi
  • Enrique García-España
  • Molecules.2020 Jul;25(14). E3155. doi: 10.3390/molecules25143155.Epub 2020-07-10.

遺伝子発現解析によるシステムを用いたディーゼル排気粒子による鼻の炎症性機能障害の生物学的ネットワークの解明

Gene Expression Analysis to Investigate Biological Networks Underlying Nasal Inflammatory Dysfunctions Induced by Diesel Exhaust Particles Using an System.
  • Hyun Soo Kim
  • Byeong-Gon Kim
  • Sohyeon Park
  • Nahyun Kim
  • An-Soo Jang
  • Young Rok Seo
  • Moo Kyun Park
  • Ann. Otol. Rhinol. Laryngol..2020 Mar;129(3):245-255. doi: 10.1177/0003489419883289.Epub 2019-10-24.

南アフリカにおけるロタウイルスワクチン導入前の時代に流通していた初の非定型DS-1様G1P8ロタウイルス株の発見

Uncovering the First Atypical DS-1-like G1P[8] Rotavirus Strains That Circulated during Pre-Rotavirus Vaccine Introduction Era in South Africa.
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  • Milton T Mogotsi
  • Sebotsana P Rasebotsa
  • Mapaseka L Seheri
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  • Valantine N Ndze
  • Francis E Dennis
  • Khuzwayo C Jere
  • Martin M Nyaga
  • Pathogens.2020 May;9(5). E391. doi: 10.3390/pathogens9050391.Epub 2020-05-20.

イタリアの第三次医療機関におけるホルミウムレーザー前立腺摘出術。バイポーラTURPおよび開放型前立腺摘除術と比較したプロスペクティブなコスト分析

Holmium laser prostatectomy in a tertiary Italian center: A prospective cost analysis in comparison with bipolar TURP and open prostatectomy.
  • Riccardo Schiavina
  • Lorenzo Bianchi
  • Marco Giampaoli
  • Marco Borghesi
  • Hussam Dababneh
  • Francesco Chessa
  • Cristian Pultrone
  • Andrea Angiolini
  • Umberto Barbaresi
  • Matteo Cevenini
  • Fabio Manferrari
  • Alessandro Bertaccini
  • Angelo Porreca
  • Eugenio Brunocilla
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原発性尿道がんに関する欧州泌尿器科学会ガイドライン（European Association of Urology Guidelines on Primary Urethral Carcinoma-2020 Update）

European Association of Urology Guidelines on Primary Urethral Carcinoma-2020 Update.
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  • Richard Cathomas
  • Eva M Compérat
  • Nigel C Cowan
  • Antoine G van der Heijden
  • Virginia Hernández
  • Estefania E Linares Espinós
  • Anja Lorch
  • Yann Neuzillet
  • Maria J Ribal
  • Mathieu Rouanne
  • George N Thalmann
  • Erik Veskimäe
  • Alfred J Witjes
  • Eur Urol Oncol.2020 Jun;S2588-9311(20)30081-X. doi: 10.1016/j.euo.2020.06.003.Epub 2020-06-27.

チオレドキシン、チオレドキシン相互作用タンパク質、妊娠糖尿病における転写3のトランスデューサーおよびアクチベーター

Thioredoxin, thioredoxin interacting protein and transducer and activator of transcription 3 in gestational diabetes.
  • Yael Pasternak
  • Meital Ohana
  • Tal Biron-Shental
  • Keren Cohen-Hagai
  • Sydney Benchetrit
  • Tali Zitman-Gal
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神経ペプチド物質Pは、ヒトの副腎におけるアルドステロンの分泌を調節する

The neuropeptide substance P regulates aldosterone secretion in human adrenals.
  • Julien Wils
  • Céline Duparc
  • Anne-Françoise Cailleux
  • Antoine-Guy Lopez
  • Caroline Guiheneuf
  • Isabelle Boutelet
  • Hadrien-Gaël Boyer
  • Christophe Dubessy
  • Saloua Cherifi
  • Bruno Cauliez
  • Françoise Gobet
  • Guillaume Defortescu
  • Jean-François Ménard
  • Estelle Louiset
  • Hervé Lefebvre
  • Nat Commun.2020 May;11(1):2673. 10.1038/s41467-020-16470-8. doi: 10.1038/s41467-020-16470-8.Epub 2020-05-29.

全身性エリテマトーデス患者における大動脈周囲炎とびまん性心内膜下血管炎-ループスフレアか共存疾患か？

Periaortitis and diffuse subendocardial vasculitis in a patient with systemic lupus erythematosus - Lupus flare or a coexisting disease?
  • Ourania Gioti
  • Evangelos Theotikos
  • Argyro Lazarini
  • Andreas S Triantafyllis
  • Alexia Balanika
  • Maria Boutsikou
  • Pavlos Tsinivizov
  • Antonis Fanouriakis
  • Antonia Elezoglou
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インフルエンザA M2プロトンチャネルのランダム突然変異解析により、新しい耐性変異体が発見された

Random Mutagenesis Analysis of the Influenza A M2 Proton Channel Reveals Novel Resistance Mutants.
  • Paul Santner
  • João Miguel da Silva Martins
  • Caroline Kampmeyer
  • Rasmus Hartmann-Petersen
  • Jonas S Laursen
  • Amelie Stein
  • Christian A Olsen
  • Isaiah T Arkin
  • Jakob R Winther
  • Martin Willemoës
  • Kresten Lindorff-Larsen
  • Biochemistry.2018 10;57(41):5957-5968. doi: 10.1021/acs.biochem.8b00722.Epub 2018-10-03.

脂質コアナノ粒子に担持されたエトポシドを用いた導入療法が奏効しない急性骨髄性白血病における骨髄移植条件付けのための新規アプローチ：パイロット臨床試験

Novel approach for bone marrow transplantation conditioning in acute myeloid leukemia not responding to the induction therapy using etoposide carried in lipid core nanoparticles: a pilot clinical study.
  • Sandra S Rohr
  • Raul C Maranhão
  • Thauany M Tavoni
  • Aleksandra T Morikawa
  • Kelsy Areco
  • Debora F Deus
  • José S R Oliveira
  • Biol. Blood Marrow Transplant..2020 Jul;S1083-8791(20)30443-2. doi: 10.1016/j.bbmt.2020.07.010.Epub 2020-07-16.

血漿中の糖化CD59（gCD59）は、妊娠糖尿病（GDM）を持つ女性の診断、管理、フォローアップのための新しいバイオマーカーであり、プロスペクティブコホート研究のプロトコルです

Plasma glycated CD59 (gCD59), a novel biomarker for the diagnosis, management and follow up of women with Gestational Diabetes (GDM) - protocol for prospective cohort study.
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  • P M O'Shea
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  • BMC Pregnancy Childbirth.2020 Jul;20(1):412. 10.1186/s12884-020-03090-9. doi: 10.1186/s12884-020-03090-9.Epub 2020-07-18.

臨床的な椎体CTのセグメンテーションに関する多施設共同マイルストーン研究

A multi-center milestone study of clinical vertebral CT segmentation.
  • Jianhua Yao
  • Joseph E Burns
  • Daniel Forsberg
  • Alexander Seitel
  • Abtin Rasoulian
  • Purang Abolmaesumi
  • Kerstin Hammernik
  • Martin Urschler
  • Bulat Ibragimov
  • Robert Korez
  • Tomaž Vrtovec
  • Isaac Castro-Mateos
  • Jose M Pozo
  • Alejandro F Frangi
  • Ronald M Summers
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TLCバイオオートグラフィ技術を用いたアルメニアのハーブの粗抽出物からのファイトケミカルスクリーニングと抗菌成分の検出

Phytochemical Screening and Detection of Antibacterial Components from Crude Extracts of Some Armenian Herbs Using TLC-Bioautographic Technique.
  • Mikayel Ginovyan
  • Arpine Ayvazyan
  • Armine Nikoyan
  • Lilit Tumanyan
  • Armen Trchounian
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定量的フローレシオによる残存機能的SYNTAXスコアと再灌流術後の運動能力の向上

Residual functional SYNTAX score by quantitative flow ratio and improvement of exercise capacity after revascularization.
  • Seung Hun Lee
  • Ki Hong Choi
  • Joo Myung Lee
  • Doosup Shin
  • Doyeon Hwang
  • Hyun Kuk Kim
  • Joon-Hyung Doh
  • Chang-Wook Nam
  • Eun-Seok Shin
  • Mi Ja Jang
  • Se Young Im
  • Taek Kyu Park
  • Jeong Hoon Yang
  • Young Bin Song
  • Joo-Yong Hahn
  • Seung-Hyuk Choi
  • Bon-Kwon Koo
  • Hyeon-Cheol Gwon
  • Catheter Cardiovasc Interv.2020 Jul;doi: 10.1002/ccd.29118.Epub 2020-07-03.

空気圧拡張術後に症状が再発したアカラシア患者に対して、口腔内視鏡下筋切開術は高い効果を示した

Peroral endoscopic myotomy is highly effective for achalasia patients with recurrent symptoms after pneumatic dilatation.
  • Madhusudhan R Sanaka
  • George Khoudari
  • Malav Parikh
  • Prashanthi N Thota
  • Rocio Lopez
  • Niyati Gupta
  • Scott Gabbard
  • Monica Ray
  • Sudish Murthy
  • Siva Raja
  • Surg Endosc.2020 Jun;10.1007/s00464-020-07737-8. doi: 10.1007/s00464-020-07737-8.Epub 2020-06-18.

マウスの糖尿病時の急性膵炎の重症度を低下させるための新規予防的アプローチとしてのセリン投与

Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice.
  • Rong Chen
  • Thorsten Hornemann
  • Saša Štefanić
  • Elisabeth M Schraner
  • Richard Zuellig
  • Theresia Reding
  • Ermanno Malagola
  • Darren C Henstridge
  • Andrew P Hills
  • Rolf Graf
  • Sabrina Sonda
  • Diabetologia.2020 May;10.1007/s00125-020-05156-x. doi: 10.1007/s00125-020-05156-x.Epub 2020-05-08.

カタプレキシーを伴うナルコレプシーを有する小児および青年におけるオキシビン酸ナトリウムの母集団および非母集団的薬物動態は、体重に応じた投与を支持する

Population and Noncompartmental Pharmacokinetics of Sodium Oxybate Support Weight-Based Dosing in Children and Adolescents With Narcolepsy With Cataplexy.
  • Cuiping Chen
  • Carol L Rosen
  • Chad Ruoff
  • Leslie H Boyce
  • Rupa Parvataneni
  • Katie Zomorodi
  • Scott Brantley
  • Mark Sale
  • Giuseppe Plazzi
  • Clin Transl Sci.2020 Mar;doi: 10.1111/cts.12780.Epub 2020-03-26.

中国の子どもと青年の民族性、社会経済的地位、栄養状態。2005 年から 2014 年までの 3 回連続した全国調査から得られた知見

Ethnicity, socioeconomic status and the nutritional status of Chinese children and adolescents: Findings from three consecutive national surveys between 2005 and 2014.
  • Yanhui Dong
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  • Bin Dong
  • Zhiyong Zou
  • Yide Yang
  • Rongbin Xu
  • Zhenghe Wang
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老年期うつ病を対象としたパイロット試験において、エスシタロプラムとメマンチンの併用投与は、エスシタロプラムとプラセボに比べて灰白質体積と皮質厚を増加させた

Combined treatment with escitalopram and memantine increases gray matter volume and cortical thickness compared to escitalopram and placebo in a pilot study of geriatric depression.
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安定同位体分析とマイクロデブリ分析を用いた中世以降のロンドンの2つの集団の食生活の集学的調査

Multidisciplinary investigations of the diets of two post-medieval populations from London using stable isotopes and microdebris analysis.
  • Madeleine Bleasdale
  • Paola Ponce
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  • Archaeol Anthropol Sci.2019;11(11):6161-6181. 910. doi: 10.1007/s12520-019-00910-8.Epub 2019-08-16.

コリン作動性、ニコチン作動性、βアドレナリン作動性皮膚血管拡張の性差。一酸化窒素合成酵素、シクロオキシゲナーゼ、Kチャネルの役割

Sex-differences in cholinergic, nicotinic, and β-adrenergic cutaneous vasodilation: Roles of nitric oxide synthase, cyclooxygenase, and K channels.
  • Naoto Fujii
  • Gregory W McGarr
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  • Microvasc. Res..2020 Jun;131:104030. S0026-2862(20)30090-X. doi: 10.1016/j.mvr.2020.104030.Epub 2020-06-09.

CB-6644はRUVBL1/2複合体の選択的阻害剤であり、抗がん作用を有する

CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity.
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  • Mary-Kamala Menon
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  • Antonett Madriaga
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dl-マンデル酸は高い精子固定化活性と低膣刺激性を示します。避妊のための潜在的な非界面活性剤精子殺傷剤

dl-Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation: A potential non-surfactant spermicide for contraception.
  • Minjie Xia
  • Mingjun Yang
  • Yuzhu Wang
  • Fang Tian
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鼠径ヘルニアの完全腹腔外修復術における適切なメッシュサイズは、術中の筋開口部の測定値に基づいて決定した

Appropriate mesh size in the totally extraperitoneal repair of groin hernias based on the intraoperative measurement of the myopectineal orifice.
  • Takahiro Hiratsuka
  • Yuji Shigemitsu
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歯内療法的に治療された歯の歯周病および歯内療法状態尺度、および上顎洞異常との関連。コーンビームコンピューター断層撮影による研究

Periapical and Endodontic Status Scale for Endodontically Treated Teeth and Their Association with Maxillary Sinus Abnormalities: A Cone-beam Computed Tomographic Study.
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  • Francielle Silvestre Verner
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  • Sibele Nascimento de Aquino
  • Antônio Carlos Pires Carvalho
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腰椎・仙骨の脊柱管腫患者の予後因子としてのC反応性蛋白質--単一施設でのパイロット研究

C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum--a single center pilot study.
  • Gerhard Martin Hobusch
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  • Irene Sulzbacher
  • Reinhard Windhager
  • Joannis Panotopoulos
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核内受容体結合型SETドメイン蛋白質1の不活性化は、GATA1制御の赤血球分化を阻害し、赤血球性白血病を引き起こす

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
  • Katharina Leonards
  • Marwa Almosailleakh
  • Samantha Tauchmann
  • Frederik Otzen Bagger
  • Cécile Thirant
  • Sabine Juge
  • Thomas Bock
  • Hélène Méreau
  • Matheus F Bezerra
  • Alexandar Tzankov
  • Robert Ivanek
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  • Antoine H F M Peters
  • Thomas Mercher
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  • Nat Commun.2020 Jun;11(1):2807. 10.1038/s41467-020-16179-8. doi: 10.1038/s41467-020-16179-8.Epub 2020-06-12.

酵母ゲノムDNA中へのリボヌクレオチドの取り込みは、デオキシアデノシンに先行してシトシンとグアノシンが優先的に組み込まれることが明らかになった

Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine.
  • Sathya Balachander
  • Alli L Gombolay
  • Taehwan Yang
  • Penghao Xu
  • Gary Newnam
  • Havva Keskin
  • Waleed M M El-Sayed
  • Anton V Bryksin
  • Sijia Tao
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糖尿病性足潰瘍患者におけるアンジオポエチン-2およびその他の選択された循環シグナル分子のレベルに対する陰圧創傷治療の効果

Effects of Negative Pressure Wound Therapy on Levels of Angiopoetin-2 and Other Selected Circulating Signaling Molecules in Patients with Diabetic Foot Ulcer.
  • Jerzy Hohendorff
  • Anna Drozdz
  • Sebastian Borys
  • Agnieszka H Ludwig-Slomczynska
  • Beata Kiec-Wilk
  • Ewa L Stepien
  • Maciej T Malecki
  • J Diabetes Res.2019;2019:1756798. doi: 10.1155/2019/1756798.Epub 2019-10-28.

サルモネラタイファイのIII型分泌系を高発現させることで、単球由来マクロファージの細胞傷害性を高めることが明らかになった

Hyperexpression of type III secretion system of Salmonella Typhi linked to a higher cytotoxic effect to monocyte-derived macrophages by activating inflammasome.
  • Hsin-Hung Lin
  • Hsiu-Ling Chen
  • Rajendra Prasad Janapatla
  • Chyi-Liang Chen
  • Cheng-Hsun Chiu
  • Microb. Pathog..2020 Sep;146:104222. S0882-4010(20)30509-X. doi: 10.1016/j.micpath.2020.104222.Epub 2020-05-06.

地中海に入る硝酸塩負荷へのタフナ集水域(アフリカ北西部)の寄与を評価するためのSWATモデルの適用

Applications of a SWAT model to evaluate the contribution of the Tafna catchment (north-west Africa) to the nitrate load entering the Mediterranean Sea.
  • Amin Zettam
  • Amina Taleb
  • Sabine Sauvage
  • Laurie Boithias
  • Nouria Belaidi
  • José Miguel Sanchez-Perez
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テストステロンはβアドレナリン受容体のゲノム転写を増強し、気道平滑筋のサルブタモール弛緩を増加させる

Testosterone augments β adrenergic receptor genomic transcription increasing salbutamol relaxation in airway smooth muscle.
  • Abril Carbajal-García
  • Jorge Reyes-García
  • María F Casas-Hernández
  • Edgar Flores-Soto
  • Verónica Díaz-Hernández
  • Héctor Solís-Chagoyán
  • Bettina Sommer
  • Luis M Montaño
  • Mol. Cell. Endocrinol..2020 Jun;510:110801. S0303-7207(20)30101-5. doi: 10.1016/j.mce.2020.110801.Epub 2020-04-08.

低侵襲治療用超音波。神経腫瘍学における超音波ガイド付き超音波アブレーション

Minimally invasive therapeutic ultrasound: Ultrasound-guided ultrasound ablation in neuro-oncology.
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  • Smruti Mahapatra
  • Alexander Perdomo-Pantoja
  • Francisco Chavez
  • Kyle Morrison
  • Kah Timothy Xiong
  • Nao J Gamo
  • Stephen Restaino
  • Nitish Thakor
  • Youseph Yazdi
  • Rajiv Iyer
  • Betty Tyler
  • Nicholas Theodore
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  • Henry Brem
  • Mari Groves
  • Alan R Cohen
  • Amir Manbachi
  • Ultrasonics.2020 Jun;108:106210. S0041-624X(20)30149-9. doi: 10.1016/j.ultras.2020.106210.Epub 2020-06-20.

グリコール酸を含む新規灌注液のスミア層除去および象牙質の化学的・機械的特性への影響

Effect of a new irrigant solution containing glycolic acid on smear layer removal and chemical/mechanical properties of dentin.
  • Débora Pereira Diniz Correia Barcellos
  • Ana Paula Farina
  • Ramiro Barcellos
  • Matheus Albino Souza
  • Márcia Borba
  • Ana Karina Bedran-Russo
  • Yuri Dal Bello
  • Cristina De Mattos Pimenta Vidal
  • Doglas Cecchin
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筋緊張性ジストロフィー1型のmRNAバイオマーカーを臨床試験で評価するための統計的フレームワークの開発に向けて

Towards development of a statistical framework to evaluate myotonic dystrophy type 1 mRNA biomarkers in the context of a clinical trial.
  • Adam Kurkiewicz
  • Anneli Cooper
  • Emily McIlwaine
  • Sarah A Cumming
  • Berit Adam
  • Ralf Krahe
  • Jack Puymirat
  • Benedikt Schoser
  • Lubov Timchenko
  • Tetsuo Ashizawa
  • Charles A Thornton
  • Simon Rogers
  • John D McClure
  • Darren G Monckton
  • PLoS ONE.2020;15(4):e0231000. PONE-D-19-24916. doi: 10.1371/journal.pone.0231000.Epub 2020-04-14.

多層の硬膜外膿瘍形成を伴う腰部化膿性脊椎二十四節気炎に対する後側スポンディロデシスを用いた単段硬膜外カテーテル注入術

Single-stage epidural catheter lavage with posterior spondylodesis in lumbar pyogenic spondylodiscitis with multilevel epidural abscess formation.
  • Sven K Tschoeke
  • Ralph Kayser
  • Jens Gulow
  • Nicolas von der Hoeh
  • Georg von Salis-Soglio
  • Christoph Heyde
  • J Neurol Surg A Cent Eur Neurosurg.2014 Nov;75(6):447-52. doi: 10.1055/s-0034-1368684.Epub 2014-02-19.

エチオピアにおける早期長時間作用型可逆性避妊薬の中止に関連する因子：2016年エチオピア人口動態・健康調査からのエビデンス

Factors associated with early long-acting reversible contraceptives discontinuation in Ethiopia: evidence from the 2016 Ethiopian demographic and health survey.
  • Gedefaw Abeje Fekadu
  • Akinyinka O Omigbodun
  • Olumuyiwa A Roberts
  • Alemayehu Worku Yalew
  • Arch Public Health.2020;78:36. 419. doi: 10.1186/s13690-020-00419-w.Epub 2020-07-01.

低酸素・再酸素化は、ミトコンドリアの透過性遷移孔を開くことで、薬剤誘発細胞毒性を悪化させる。毒性スクリーニングへの応用の可能性

Hypoxia/reoxygenation exacerbates drug-induced cytotoxicity by opening mitochondrial permeability transition pore: Possible application for toxicity screening.
  • Yugo Ikeyama
  • Tomoyuki Sato
  • Akinori Takemura
  • Shuichi Sekine
  • Kousei Ito
  • Toxicol In Vitro.2020 Sep;67:104889. S0887-2333(20)30257-5. doi: 10.1016/j.tiv.2020.104889.Epub 2020-05-14.

閉経前乳癌治療におけるトレミフェン vs. タモキシフェンの前向き無作為化試験：安全性と性器症状の解析

A prospective, randomized study of Toremifene vs. tamoxifen for the treatment of premenopausal breast cancer: safety and genital symptom analysis.
  • Jin Hong
  • Jiahui Huang
  • Lili Shen
  • Siji Zhu
  • Weiqi Gao
  • Jiayi Wu
  • Ou Huang
  • Jianrong He
  • Li Zhu
  • Weiguo Chen
  • Yafen Li
  • Xiaosong Chen
  • Kunwei Shen
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複雑な遺伝子型および一般的な脂肪減少を伴う-関連性脂質異常症の珍しい症例：遺伝学的診断が新たな特徴をカバーしていない場合

UNUSUAL PRESENTATIONS OF -ASSOCIATED LIPODYSTROPHY WITH COMPLEX PHENOTYPES AND GENERALIZED FAT LOSS: WHEN THE GENETIC DIAGNOSIS UNCOVERS NOVEL FEATURES.
  • Natalia Xavier S de Andrade
  • Suleyman Cem Adiyaman
  • Berna Demir Yuksel
  • Carla T Ferrari
  • Abdelwahab Jalal Eldin
  • Basak Ozgen Saydam
  • Canan Altay
  • Pratima Sharma
  • Nicole Bhave
  • Ann Little
  • Paul McKeever
  • Huseyin Onay
  • Sermin Ozkal
  • Mustafa Secil
  • Mustafa Nuri Yenerel
  • Baris Akinci
  • Elif A Oral
  • AACE Clin Case Rep.2020 Mar-Apr;6(2):e79-e85. doi: 10.4158/ACCR-2019-0366.Epub 2020-03-04.

オーストラリア本土への保護区移動中のファウンダーイースタンクオールズ()の基本的な健康状態と疾患の評価

BASELINE HEALTH AND DISEASE ASSESSMENT OF FOUNDER EASTERN QUOLLS () DURING A CONSERVATION TRANSLOCATION TO MAINLAND AUSTRALIA.
  • Timothy J Portas
  • Maldwyn J Evans
  • David Spratt
  • Paola K Vaz
  • Joanne M Devlin
  • Amanda Duarte Barbosa
  • Belinda A Wilson
  • Annette Rypalski
  • Claire Wimpenny
  • Don Fletcher
  • Iain J Gordon
  • Jenny Newport
  • Adrian D Manning
  • J. Wildl. Dis..2020 Jul;56(3):547-559. 10.7589/2019-05-120. doi: 10.7589/2019-05-120.Epub 2020-02-04.

ポリウレタン/ポリ(2-ヒドロキシエチルメタクリレート)/セルロースナノウィスカー足場の半貫通型ポリマーネットワークを用いたhMSCの骨形成分化の研究

Osteogenic differentiation of hMSCs on semi-interpenetrating polymer networks of polyurethane/poly(2‑hydroxyethyl methacrylate)/cellulose nanowhisker scaffolds.
  • Mohsen Shahrousvand
  • Marzieh Ghollasi
  • Ali Akbar Karimi Zarchi
  • Ali Salimi
  • Int. J. Biol. Macromol..2019 Oct;138:262-271. S0141-8130(19)32751-5. doi: 10.1016/j.ijbiomac.2019.07.080.Epub 2019-07-11.

豚2',5'-オリゴアデニル酸合成酵素1bの分子クローニングと機能特性、および豚生殖呼吸器症候群ウイルス感染に対するその効果

Molecular cloning and functional characterization of porcine 2',5'-oligoadenylate synthetase 1b and its effect on infection with porcine reproductive and respiratory syndrome virus.
  • Ruining Wang
  • Yinfeng Kang
  • Huawei Li
  • Hongfang Ma
  • Wenjia Wang
  • Yanfen Cheng
  • Pengchao Ji
  • Erqin Zhang
  • Mengmeng Zhao
  • Vet. Immunol. Immunopathol..2019 Mar;209:22-30. S0165-2427(18)30301-5. doi: 10.1016/j.vetimm.2019.01.003.Epub 2019-02-06.

Miqのマイクロプロパゲーションと畑生植物、インビトロプロパゲーションされた温室生植物およびインビトロ由来カルスのエタノール抽出物の比較抗酸化特性

Micropropagation of Miq and Comparative Antioxidant Properties of Ethanolic Extracts of the Field-Grown Plant, In Vitro Propagated and In Vitro-Derived Callus.
  • Ferid Abdulhafiz
  • Arifullah Mohammed
  • Fatimah Kayat
  • Suhana Zakaria
  • Zulhazman Hamzah
  • Ramachandra Reddy Pamuru
  • Prasada Babu Gundala
  • Mohd Farhan Hanif Reduan
  • Plants (Basel).2020 Jun;9(7). E816. doi: 10.3390/plants9070816.Epub 2020-06-29.

ウガンダの伝統的な癌治療に用いられている薬用植物。民族植物学的調査、植物化学、抗がん研究のレビュー

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies.
  • Timothy Omara
  • Ambrose K Kiprop
  • Rose C Ramkat
  • Jackson Cherutoi
  • Sarah Kagoya
  • Decrah Moraa Nyangena
  • Tsedey Azeze Tebo
  • Papias Nteziyaremye
  • Lucy Nyambura Karanja
  • Abigael Jepchirchir
  • Alfayo Maiyo
  • Betty Jematia Kiptui
  • Immaculate Mbabazi
  • Caroline Kiwanuka Nakiguli
  • Brenda Victoria Nakabuye
  • Margaret Chepkemoi Koske
  • Evid Based Complement Alternat Med.2020;2020:3529081. doi: 10.1155/2020/3529081.Epub 2020-03-15.

外因性エリスロポエチンの神経保護効果（WistarラットにおけるN-メチル-D-アスパラギン酸介在性網膜神経節細胞死を抑制するためのアポトーシス因子のダウンレギュレーションによる

Neuroprotective effects of exogenous erythropoietin in Wistar rats by downregulating apoptotic factors to attenuate N-methyl-D-aspartate-mediated retinal ganglion cells death.
  • Wen-Sheng Cheng
  • I-Hung Lin
  • Kathy Ming Feng
  • Zhi-Yang Chang
  • Yu Chuan Huang
  • Da-Wen Lu
  • PLoS ONE.2020;15(4):e0223208. PONE-D-19-25957. doi: 10.1371/journal.pone.0223208.Epub 2020-04-17.

ロイシンリッチリピートキナーゼ2 G2019Sキャリアの末梢血単核細胞におけるインビトロキナーゼ活性の上昇。新規な酵素リンク免疫吸着アッセイベースの方法

Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine-Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme-Linked Immunosorbent Assay-Based Method.
  • Katerina Melachroinou
  • Min Suk Kang
  • Christopher Liong
  • Sushma Narayan
  • Najah Levers
  • Neal Joshi
  • Katie Kopil
  • Samantha J Hutten
  • Marco A S Baptista
  • Shalini Padmanabhan
  • Un Jung Kang
  • Leonidas Stefanis
  • Roy N Alcalay
  • Hardy J Rideout
  • Mov. Disord..2020 Jul;doi: 10.1002/mds.28175.Epub 2020-07-11.

アカゲザルにおける炎症表現型は、CD161発現細胞における上皮バリア保護機能の低下とプロ炎症機能の亢進に関連している

Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells.
  • Edith M Walker
  • Nadia Slisarenko
  • Giovanni L Gerrets
  • Patricia J Kissinger
  • Elizabeth S Didier
  • Marcelo J Kuroda
  • Ronald S Veazey
  • S Michal Jazwinski
  • Namita Rout
  • Geroscience.2019 12;41(6):739-757. 10.1007/s11357-019-00099-7. doi: 10.1007/s11357-019-00099-7.Epub 2019-11-11.

コカインとエタノールの併用静脈内投与が若年成人ラットの行動およびアミノ酸プロファイルに及ぼす影響

The effects of combined intravenous cocaine and ethanol self-administration on the behavioral and amino acid profile of young adult rats.
  • Alberto Marcos
  • Mario Moreno
  • Javier Orihuel
  • Marcos Ucha
  • Ana Mª de Paz
  • Alejandro Higuera-Matas
  • Roberto Capellán
  • Antonio L Crego
  • María-Rosa Martínez-Larrañaga
  • Emilio Ambrosio
  • Arturo Anadón
  • PLoS ONE.2020;15(3):e0227044. PONE-D-19-18229. doi: 10.1371/journal.pone.0227044.Epub 2020-03-23.

エストニアにおけるアルコール乱用のための最小誘導オンライン自助介入の有効性をテストする：無作為化比較試験の研究プロトコル

Testing the efficacy of a minimal-guidance online self-help intervention for alcohol misuse in Estonia: study protocol of a randomized controlled trial.
  • Esta Kaal
  • Michael P Schaub
  • Andreas Wenger
  • Triin Ülesoo
  • Matthijs Blankers
  • Severin Haug
  • David D Ebert
  • Heleen Riper
  • Matthew Keough
  • Helen Noormets
  • Karin Kilp
  • BMC Public Health.2020 May;20(1):790. 10.1186/s12889-020-08791-6. doi: 10.1186/s12889-020-08791-6.Epub 2020-05-27.

前立腺癌の特性評価のためのマルチパラメトリックMRI。ラジオミクスモデルとPI-RADSおよび臨床パラメータの組み合わせ

Multiparametric MRI for Prostate Cancer Characterization: Combined Use of Radiomics Model with PI-RADS and Clinical Parameters.
  • Piotr Woźnicki
  • Niklas Westhoff
  • Thomas Huber
  • Philipp Riffel
  • Matthias F Froelich
  • Eva Gresser
  • Jost von Hardenberg
  • Alexander Mühlberg
  • Maurice Stephan Michel
  • Stefan O Schoenberg
  • Dominik Nörenberg
  • Cancers (Basel).2020 Jul;12(7). E1767. doi: 10.3390/cancers12071767.Epub 2020-07-02.

多機能オピオイド受容体アゴニストと新規大環状テトラペプチドによるアンタゴニストは、モルヒネを求める行動の回復を防ぐ

Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine-seeking behaviour.
  • Ariana C Brice-Tutt
  • Lisa L Wilson
  • Shainnel O Eans
  • Heather M Stacy
  • Chloe A Simons
  • Grant G Simpson
  • Jeremy S Coleman
  • Michael J Ferracane
  • Jane V Aldrich
  • Jay P McLaughlin
  • Br. J. Pharmacol..2020 Jun;doi: 10.1111/bph.15165.Epub 2020-06-19.

また、de novoトランスクリプトーム解析により、暗成長したニンジンの貯蔵根のカロテノイド合成には、光知覚遺伝子が必要であることが明らかになった

A de novo transcriptome analysis revealed that photomorphogenic genes are required for carotenoid synthesis in the dark-grown carrot taproot.
  • Daniela Arias
  • Jonathan Maldonado
  • Herman Silva
  • Claudia Stange
  • Mol. Genet. Genomics.2020 Jul;10.1007/s00438-020-01707-4. doi: 10.1007/s00438-020-01707-4.Epub 2020-07-12.

哺乳類α7ニコチン性アセチルコリン受容体の正のアロステリックモジュレーターであるPNU-120596は、腹足動物Lymnaea stagnalisのリガンド-ゲートされたクロライド選択性チャネルの負のモジュレーターである

PNU-120596, a positive allosteric modulator of mammalian α7 nicotinic acetylcholine receptor, is a negative modulator of ligand-gated chloride-selective channels of the gastropod Lymnaea stagnalis.
  • Catherine A Vulfius
  • Dmitrii S Lebedev
  • Elena V Kryukova
  • Denis S Kudryavtsev
  • Sergey N Kolbaev
  • Yuri N Utkin
  • Victor I Tsetlin
  • J. Neurochem..2020 Apr;doi: 10.1111/jnc.15020.Epub 2020-04-04.

GARPおよびEARP複合体のVps52サブユニットは、海馬ニューロンのニューライト伸長をネガティブに制御する新規なArf6相互作用タンパク質であることが示唆された

The Vps52 subunit of the GARP and EARP complexes is a novel Arf6-interacting protein that negatively regulates neurite outgrowth of hippocampal neurons.
  • Kanta Ibuchi
  • Masahiro Fukaya
  • Tetsuro Shinohara
  • Yoshinobu Hara
  • Tomoko Shiroshima
  • Takeyuki Sugawara
  • Hiroyuki Sakagami
  • Brain Res..2020 Oct;1745:146905. S0006-8993(20)30261-4. doi: 10.1016/j.brainres.2020.146905.Epub 2020-05-28.

閉経後女性におけるガレクチン-3遺伝子発現に対する高強度インターバルトレーニングと中強度有酸素連続トレーニングの効果。無作為化対照試験

Effect of High-Intensity Interval Training Versus Moderate-Intensity Aerobic Continuous Training on Galectin-3 Gene Expression in Postmenopausal Women: A Randomized Controlled Trial.
  • Diana Keyhani
  • Bakhtyar Tartibian
  • Arezou Dabiri
  • Ana Maria Botelho Teixeira
  • J Aging Phys Act.2020 Jul;:1-9. japa.2019-0213. doi: 10.1123/japa.2019-0213.Epub 2020-07-17.

心臓外科医、臨床医、インターベンショナルカーディオロジスト間でのSyntaxスコアのオブザーバー間変動

Inter-observer variation of Syntax score among cardiac surgeons, clinical and interventional cardiologists.
  • Gustavo Neves de Araujo
  • Tiago Luiz Luz Leiria
  • Mariana Vargas Furtado
  • Bruno da Silva Matte
  • Guilherme Pinheiro Machado
  • Ana Maria Krepsky
  • Luiz Carlos Corsetti Bergoli
  • Sandro Cadaval Goncalves
  • Marco Vugman Wainstein
  • Carisi Anne Polanczyk
  • Ther Adv Cardiovasc Dis.2020 Jan-Dec;14:1753944720924254. doi: 10.1177/1753944720924254.

地域居住者である健康な男性と閉経後の女性のコホートにおける骨の微細構造および強度の加齢変化と食事性酸負荷との関連

Associations between age-related changes in bone microstructure and strength and dietary acid load in a cohort of community-dwelling, healthy men and postmenopausal women.
  • Maria Papageorgiou
  • Fanny Merminod
  • Thierry Chevalley
  • Bert van Rietbergen
  • Serge Ferrari
  • René Rizzoli
  • Emmanuel Biver
  • Am. J. Clin. Nutr..2020 Jul;nqaa191. doi: 10.1093/ajcn/nqaa191.Epub 2020-07-17.

分泌されたLysMエフェクターは、キチン依存性のホモ二量体重合を介して真菌のハイパーを保護する

A secreted LysM effector protects fungal hyphae through chitin-dependent homodimer polymerization.
  • Andrea Sánchez-Vallet
  • Hui Tian
  • Luis Rodriguez-Moreno
  • Dirk-Jan Valkenburg
  • Raspudin Saleem-Batcha
  • Stephan Wawra
  • Anja Kombrink
  • Leonie Verhage
  • Ronnie de Jonge
  • H Peter van Esse
  • Alga Zuccaro
  • Daniel Croll
  • Jeroen R Mesters
  • Bart P H J Thomma
  • PLoS Pathog..2020 Jun;16(6):e1008652. PPATHOGENS-D-19-01885. doi: 10.1371/journal.ppat.1008652.Epub 2020-06-23.

タイの初期全身性硬化症（SSc）患者における心エコー検査で決定された肺高血圧の発生率、予測因子、生存率：初期コホート研究

Incidence, predictors, and survival of pulmonary hypertension determined by echocardiography in Thai patients with early systemic sclerosis (SSc): inception cohort study.
  • Suparaporn Wangkaew
  • Panupong Pota
  • Narawudt Prasertwittayakij
  • Arintaya Phrommintikul
  • Clin. Rheumatol..2020 Jul;10.1007/s10067-020-05296-w. doi: 10.1007/s10067-020-05296-w.Epub 2020-07-18.

ヌクレアーゼフリー水中および防腐剤中の Burkholderia cepacia complex の検出のための培養法、リアルタイム PCR 法、液滴デジタル PCR 法、およびフローサイトメトリー法の比較

A comparison of culture-based, real-time PCR, droplet digital PCR and flow cytometric methods for the detection of Burkholderia cepacia complex in nuclease-free water and antiseptics.
  • Youngbeom Ahn
  • Bailey Gibson
  • Anna Williams
  • Pierre Alusta
  • Dan A Buzatu
  • Yong-Jin Lee
  • John J LiPuma
  • David Hussong
  • Bernard Marasa
  • Carl E Cerniglia
  • J. Ind. Microbiol. Biotechnol..2020 Jul;10.1007/s10295-020-02287-3. doi: 10.1007/s10295-020-02287-3.Epub 2020-07-15.

小児HIV患者の高活性抗レトロウイルス療法へのアドヒアランスと生活の質に関する介護者の視点に関する横断的研究

A cross-sectional study on caregivers' perspective of the quality of life and adherence of paediatric HIV patients to highly active antiretroviral therapy.
  • Michael Lahai
  • Peter Bai James
  • Noel Nen'man Wannang
  • Haja Ramatulai Wurie
  • Sorie Conteh
  • Abdulai Jawo Bah
  • Mohamed Samai
  • BMC Pediatr.2020 Jun;20(1):286. 10.1186/s12887-020-02194-7. doi: 10.1186/s12887-020-02194-7.Epub 2020-06-09.

大胸部手術を受けている成人患者を対象とした維持輸液療法（TOPMAST）：単施設無作為化比較二重盲検試験で、ナトリウム1リットルあたり54mmolと154を比較しました

154 compared to 54 mmol per liter of sodium in intravenous maintenance fluid therapy for adult patients undergoing major thoracic surgery (TOPMAST): a single-center randomized controlled double-blind trial.
  • Niels Van Regenmortel
  • Steven Hendrickx
  • Ella Roelant
  • Ingrid Baar
  • Karolien Dams
  • Karen Van Vlimmeren
  • Bart Embrecht
  • Anouk Wittock
  • Jeroen M Hendriks
  • Patrick Lauwers
  • Paul E Van Schil
  • Amaryllis H Van Craenenbroeck
  • Walter Verbrugghe
  • Manu L N G Malbrain
  • Tim Van den Wyngaert
  • Philippe G Jorens
  • Intensive Care Med.2019 10;45(10):1422-1432. 10.1007/s00134-019-05772-1. doi: 10.1007/s00134-019-05772-1.Epub 2019-10-01.

ラット遠位結腸では、平行中間コンダクタンスKとClチャネルの活性が基底側膜を横切ってエレクトロンニュートラルKの出口を媒介している

Parallel intermediate conductance K and Cl channel activity mediates electroneutral K exit across basolateral membranes in rat distal colon.
  • Shabina Rehman
  • Karthikeyan Narayanan
  • Andrew J Nickerson
  • Steven D Coon
  • Kazi Mirajul Hoque
  • Geoffrey I Sandle
  • Vazhaikkurichi M Rajendran
  • Am. J. Physiol. Gastrointest. Liver Physiol..2020 Aug;319(2):G142-G150. doi: 10.1152/ajpgi.00011.2020.Epub 2020-06-22.

解説。p-トルエンスルホン酸/塩化コリン深層共晶溶媒を加水分解媒体として用いた棒状キチンナノ結晶の調製、特性評価、応用

Commentary: Preparation, characterization and application of rod-like chitin nanocrystal by using p-toluenesulfonic acid/choline chloride deep eutectic solvent as a hydrolytic media.
  • Wen-Hao Jiang
  • Wei-Ming Gu
  • Mei-Jie Xiong
  • Kang-Ping He
  • Xiao-Ying Xu
  • Wen-Xi Zhang
  • Rui-Feng Shen
  • Lin-Hao Lai
  • Yong-Si Lv
  • Shi-Lin Cao
  • Front Bioeng Biotechnol.2020;8:505. doi: 10.3389/fbioe.2020.00505.Epub 2020-06-12.

患者中心のケアのための機会。慢性疾患を対象としたモバイルヘルス試験における性と性別に基づくデータの二次分析の結果

An opportunity for patient-centered care: Results from a secondary analysis of sex- and gender-based data in mobile health trials for chronic medical conditions.
  • Jiani Wang
  • Jürgen Barth
  • Irene Göttgens
  • Karma Emchi
  • Daniel Pach
  • Sabine Oertelt-Prigione
  • Maturitas.2020 Aug;138:1-7. S0378-5122(20)30260-7. doi: 10.1016/j.maturitas.2020.05.003.Epub 2020-05-12.

白血球比は、急性肝硬変および急性-慢性肝不全の急性分解性肝硬変患者における死亡率のバイオマーカーである

Leucocyte ratios are biomarkers of mortality in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure.
  • Christine Bernsmeier
  • Anna Cavazza
  • Evangelia M Fatourou
  • Eleni Theocharidou
  • Abisoye Akintimehin
  • Benjamin Baumgartner
  • Ameet Dhar
  • Georg Auzinger
  • Mark Thursz
  • William Bernal
  • Julia A Wendon
  • Constantine J Karvellas
  • Charalambos G Antoniades
  • Mark J W McPhail
  • Aliment. Pharmacol. Ther..2020 Jul;doi: 10.1111/apt.15932.Epub 2020-07-19.

Tityus stigmurus毒は、血液および精巣細胞に遺伝的損傷を与え、マウスの配偶子形成系細胞の数および形態に影響を与える

Tityus stigmurus venom causes genetic damage in blood and testicular cells and affects the number and morphology of gametogenic lineage cells in mice.
  • Meykson A Silva
  • Talita G Souza
  • Maria E G Melo
  • Jeanderson M Silva
  • José R Lima
  • André F A Lira
  • Francisco C A de Aguiar-Júnior
  • René D Martins
  • Roberta J B Jorge
  • Cristiano A Chagas
  • Valéria W Teixeira
  • Álvaro A C Teixeira
  • Toxicon.2020 Jul;S0041-0101(20)30310-X. doi: 10.1016/j.toxicon.2020.07.006.Epub 2020-07-10.

自由フラップ再建を伴う頭頸部手術を受けた患者における多剤併用鎮痛薬投与と周術期オピオイド要求量の関連性

Association Between Multimodal Analgesia Administration and Perioperative Opioid Requirements in Patients Undergoing Head and Neck Surgery With Free Flap Reconstruction.
  • Catherine N Vu
  • Carol M Lewis
  • Neil S Bailard
  • Ravish Kapoor
  • M Laura Rubin
  • Gang Zheng
  • JAMA Otolaryngol Head Neck Surg.2020 Jun;2767511. doi: 10.1001/jamaoto.2020.1170.Epub 2020-06-18.

抽出物の化学療法の可能性：男性ラットにおけるトラマドール長期投与後の抗不妊薬としてのcGMP特異的PDE5阻害剤

Chemotherapeutic Potential of Extract: The cGMP-Specific PDE5 Inhibitor as Anti-Infertility Agent Following Long-Term Administration of Tramadol in Male Rats.
  • Ahmed S Abdelaziz
  • Mohamed A Kamel
  • Amany I Ahmed
  • Shimaa I Shalaby
  • Salama M El-Darier
  • Amany Magdy Beshbishy
  • Gaber El-Saber Batiha
  • Suliman Y Alomar
  • Dina M Khodeer
  • Antibiotics (Basel).2020 Jun;9(6). E318. doi: 10.3390/antibiotics9060318.Epub 2020-06-11.

乳がん患者における腋窩リンパ節摘出術後の術後鎮痛剤投与後の慢性的な副作用：前向き二重盲検無作為化試験の結果

Chronic adverse effects after an axillary lymphadenectomy in breast cancer patients after administering weaker and stronger postoperative analgesia: results of a prospective double-blind randomized study.
  • Nikola Besic
  • Jaka Smrekar
  • Branka Strazisar
  • Breast Cancer Res. Treat..2020 Aug;182(3):655-663. 10.1007/s10549-020-05713-3. doi: 10.1007/s10549-020-05713-3.Epub 2020-06-18.

依存性受容体UNC5Aは、乳がんの腔内から基底部への可塑性と転移を制限する

Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.
  • Maria B Padua
  • Poornima Bhat-Nakshatri
  • Manjushree Anjanappa
  • Mayuri S Prasad
  • Yangyang Hao
  • Xi Rao
  • Sheng Liu
  • Jun Wan
  • Yunlong Liu
  • Kyle McElyea
  • Max Jacobsen
  • George Sandusky
  • Sandra Althouse
  • Susan Perkins
  • Harikrishna Nakshatri
  • Breast Cancer Res..2018 05;20(1):35. 10.1186/s13058-018-0963-5. doi: 10.1186/s13058-018-0963-5.Epub 2018-05-02.

二塩化ラヂウム223で治療されたmCRPC患者の保護因子としての一次根治的前立腺摘出術または切除的放射線治療。イタリアの多施設共同研究

Primary Radical Prostatectomy or Ablative Radiotherapy as Protective Factors for Patients With mCRPC Treated With Radium-223 Dichloride: An Italian Multicenter Study.
  • Viviana Frantellizzi
  • Renato Costa
  • Manlio Mascia
  • Angela Spanu
  • Alessio Farcomeni
  • Maria Licari
  • Luca Cindolo
  • Susanna Nuvoli
  • Mariano Pontico
  • Giuseppe De Vincentis
  • Clin Genitourin Cancer.2020 Jun;18(3):185-191. S1558-7673(19)30313-1. doi: 10.1016/j.clgc.2019.10.009.Epub 2019-10-16.

肺移植患者における胃食道逆流と微小吸引。単一の食道マノメトリーとpHプローブによるモニタリング試験の有用性

Gastroesophageal Reflux and Microaspiration in Lung Transplant Recipients: The Utility of a Single Esophageal Manometry and pH Probe Monitoring Study.
  • J Gualdoni
  • J Ritzenthaler
  • J Burlen
  • A Stocker
  • T Abell
  • J Roman
  • D R Nunley
  • Transplant. Proc..2020 Apr;52(3):977-981. S0041-1345(19)31325-9. doi: 10.1016/j.transproceed.2020.01.019.Epub 2020-03-07.

マイノリティストレスのマルチレベルドメインの検討。男女の性交渉を行うラティーナ女性における薬物使用と心身の健康への示唆

Examination of multilevel domains of minority stress: Implications for drug use and mental and physical health among Latina women who have sex with women and men.
  • Alice Cepeda
  • Kathryn M Nowotny
  • Jessica Frankeberger
  • Esmeralda Ramirez
  • Victoria E Rodriguez
  • Tasha Perdue
  • Avelardo Valdez
  • PLoS ONE.2020;15(3):e0230437. PONE-D-19-19530. doi: 10.1371/journal.pone.0230437.Epub 2020-03-26.

耐久性のある左室補助装置の植え込み時に外科的介入を必要としたImpellaに関連した大動脈不全

Aortic insufficiency associated with Impella that required surgical intervention upon implantation of the durable left ventricular assist device.
  • Hideo Oishi
  • Toru Kondo
  • Kazuro Fujimoto
  • Masato Mutsuga
  • Ryota Morimoto
  • Ken-Ichi Hirano
  • Akinori Sawamura
  • Shingo Kazama
  • Yuki Kimura
  • Naoki Shibata
  • Hiroo Kato
  • Yoshihito Arao
  • Tasuku Kuwayama
  • Shogo Yamaguchi
  • Hiroaki Hiraiwa
  • Takahiro Okumura
  • Akihiko Usui
  • Toyoaki Murohara
  • J Artif Organs.2020 Jun;10.1007/s10047-020-01184-x. doi: 10.1007/s10047-020-01184-x.Epub 2020-06-19.

アデフォビル誘発ファンコーニ症候群による低リン血症性骨軟化症の臨床症状をデノスマブで改善：症例報告

Denosumab improves clinical manifestations of hypophosphatemic osteomalacia by adefovir-induced Fanconi syndrome: a case report.
  • Tomohisa Kunii
  • Toshie Iijima
  • Teruo Jojima
  • Masanori Shimizu
  • Masato Kase
  • Shintaro Sakurai
  • Takahiko Kogai
  • Isao Usui
  • Yoshimasa Aso
  • J Med Case Rep.2019 Apr;13(1):99. 10.1186/s13256-019-2018-7. doi: 10.1186/s13256-019-2018-7.Epub 2019-04-20.

遠隔性は世界中の島々で生物学的侵入を促進しています

Remoteness promotes biological invasions on islands worldwide.
  • Dietmar Moser
  • Bernd Lenzner
  • Patrick Weigelt
  • Wayne Dawson
  • Holger Kreft
  • Jan Pergl
  • Petr Pyšek
  • Mark van Kleunen
  • Marten Winter
  • César Capinha
  • Phillip Cassey
  • Stefan Dullinger
  • Evan P Economo
  • Pablo García-Díaz
  • Benoit Guénard
  • Florian Hofhansl
  • Thomas Mang
  • Hanno Seebens
  • Franz Essl
  • Proc. Natl. Acad. Sci. U.S.A..2018 09;115(37):9270-9275. 1804179115. doi: 10.1073/pnas.1804179115.Epub 2018-08-29.

確認された侵襲性肺アスペルギルス症とCOVID-19：死後の管理を支える死後所見の価値

Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management.
  • Monique Freire Santana
  • Guilherme Pivoto
  • Márcia A Araujo Alexandre
  • Djane Clarys Baía-da-Silva
  • Mayla Gabriela da Silva Borba
  • Fernando Almeida Val
  • Jose Diego Brito-Sousa
  • Gisely Cardoso Melo
  • Wuelton Marcelo Monteiro
  • João Vicente Braga Souza
  • Silviane Bezerra Pinheiro
  • Luiz Carlos Lima Ferreira
  • Felipe Gomes Naveca
  • Valdinete Alves Nascimento
  • André Lima Guerra Corado
  • Ludhmila Abrahão Hajjar
  • João Ricardo Silva Neto
  • George Alan Villarouco Siva
  • Alessandro C Pasqualotto
  • Marcus Vinícius Guimarães Lacerda
  • Rev. Soc. Bras. Med. Trop..2020;53:e20200401. S0037-86822020000100719. doi: 10.1590/0037-8682-0401-2020.Epub 2020-07-03.

扁平上皮肺癌を合併した中隔膜増殖を伴わないモノクローナル免疫グロブリン沈着を伴う増殖性糸球体腎炎

Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma.
  • Takaaki Higashihara
  • Akira Okada
  • Yasuna Nakamura
  • Hanako Saigusa
  • Shiko Homma
  • Mimiko Matsumura
  • Taiko Kusano
  • Akira Shimizu
  • Hideki Takano
  • Intern. Med..2020 Feb;59(4):557-562. doi: 10.2169/internalmedicine.2993-19.Epub 2019-10-15.

光検出性能向上のためのPbS量子ドットを用いたCsPbBrペロブスカイトナノ結晶および二層膜におけるリガンド長修飾

Ligand-Length Modification in CsPbBr Perovskite Nanocrystals and Bilayers with PbS Quantum Dots for Improved Photodetection Performance.
  • Juan Navarro Arenas
  • Ananthakumar Soosaimanickam
  • Hamid Pashaei Adl
  • Rafael Abargues
  • Pablo P Boix
  • Pedro J Rodríguez-Cantó
  • Juan P Martínez-Pastor
  • Nanomaterials (Basel).2020 Jul;10(7). E1297. doi: 10.3390/nano10071297.Epub 2020-07-02.

急性骨髄性白血病患者におけるカルバペネム非感受性グラム陰性桿菌血症のリスク因子と臨床転帰

Risk factors for and clinical outcomes of carbapenem non-susceptible gram negative bacilli bacteremia in patients with acute myelogenous leukemia.
  • Dong Hoon Shin
  • Dong-Yeop Shin
  • Chang Kyung Kang
  • Suhyeon Park
  • Jieun Park
  • Kang Il Jun
  • Taek Soo Kim
  • Youngil Koh
  • Jun Shik Hong
  • Pyoeng Gyun Choe
  • Wan Beom Park
  • Nam-Joong Kim
  • Sung-Soo Yoon
  • Inho Kim
  • Myoung-Don Oh
  • BMC Infect. Dis..2020 Jun;20(1):404. 10.1186/s12879-020-05131-2. doi: 10.1186/s12879-020-05131-2.Epub 2020-06-09.

European confederation of medical mycology expert consult-AN ECMM excellence center initiative

European confederation of medical mycology expert consult-An ECMM excellence center initiative.
  • Philipp Koehler
  • Blandine Denis
  • David W Denning
  • Jean-Pierre Gangneux
  • Martin Hoenigl
  • Dimitrios P Kontoyiannis
  • Robert Krause
  • Katrien Lagrou
  • Cornelia Lass-Flörl
  • Johan Maertens
  • Ivana Mareković
  • Jacques F Meis
  • Jean-Michel Molina
  • Sanja Pleško
  • Juergen Prattes
  • Peter-Michael Rath
  • Riina Rautemaa-Richardson
  • Malcolm Richardson
  • Esther Segal
  • Danila Seidel
  • Isabel Spriet
  • Joerg Steinmann
  • Paul E Verweij
  • Oliver A Cornely
  • Mycoses.2020 Jun;63(6):566-572. doi: 10.1111/myc.13076.Epub 2020-04-13.

プロテアソーム活性化因子であるPA200は、神経芽腫細胞においてミトコンドリアを選択的に阻害すると、細胞生存に関わる遺伝子の発現を制御する

The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells.
  • Abdennour Douida
  • Frank Batista
  • Agnieszka Robaszkiewicz
  • Pal Boto
  • Azzam Aladdin
  • Mónika Szenykiv
  • Rita Czinege
  • László Virág
  • Krisztina Tar
  • J. Cell. Mol. Med..2020 Jun;24(12):6716-6730. doi: 10.1111/jcmm.15323.Epub 2020-05-05.

アマゾン中流域を旅していると、ブラジルのリオ・ゼング盆地に生息する新種の装甲ナマズ、Aspidoras azaghal (Siluriformes: Callichthyidae)が発見されました

A journey through the Amazon Middle Earth reveals Aspidoras azaghal (Siluriformes: Callichthyidae), a new species of armored catfish from the rio Xingu basin, Brazil.
  • Luiz F C Tencatt
  • Janice Muriel-Cunha
  • Jansen Zuanon
  • Marlon F C Ferreira
  • Marcelo R Britto
  • J. Fish Biol..2020 Jul;doi: 10.1111/jfb.14467.Epub 2020-07-16.

Ezh2依存性H3K27me3修飾は、骨芽細胞におけるCYP24A1遺伝子発現のビタミンD3依存性エピジェネティック制御を動的に制御することを明らかにした

Ezh2-dependent H3K27me3 modification dynamically regulates vitamin D3-dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells.
  • Daniel Moena
  • Gino Nardocci
  • Elvis Acevedo
  • Jane Lian
  • Gary Stein
  • Janet Stein
  • Martin Montecino
  • J. Cell. Physiol..2020 Jun;235(6):5404-5412. doi: 10.1002/jcp.29428.Epub 2020-01-07.

ゴールドシール（Hydrastis canadensis L.）とその活性成分：その有効性と毒性の問題の批判的なレビュー

Goldenseal (Hydrastis canadensis L.) and its active constituents: a critical review of their efficacy and toxicological issues.
  • Sudip Kumar Mandal
  • Amal Kumar Maji
  • Siddhartha Kumar Mishra
  • Pir Mohammad Ishfaq
  • Hari Prashed Devkota
  • Ana Sanches Silva
  • Niranjan Das
  • Pharmacol. Res..2020 Jul;:105085. S1043-6618(20)31393-1. doi: 10.1016/j.phrs.2020.105085.Epub 2020-07-16.

ワイナリー副産物であるブドウの種子の親油性抗酸化物質の持続可能な供給源としての革新的な価値化と従来の価値化

Innovative and Conventional Valorizations of Grape Seeds from Winery By-Products as Sustainable Source of Lipophilic Antioxidants.
  • Ivana Dimić
  • Nemanja Teslić
  • Predrag Putnik
  • Danijela Bursać Kovačević
  • Zoran Zeković
  • Branislav Šojić
  • Živan Mrkonjić
  • Dušica Čolović
  • Domenico Montesano
  • Branimir Pavlić
  • Antioxidants (Basel).2020 Jul;9(7). E568. doi: 10.3390/antiox9070568.Epub 2020-07-01.

薬剤抵抗性局所てんかんにおけるペランパネルの併用療法としての有効性を"実世界"で検討：側頭葉てんかんを中心に

The efficacy of perampanel as adjunctive therapy in drug-resistant focal epilepsy in a "real world" context: focus on temporal lobe epilepsy.
  • Angelo Pascarella
  • Luigi Francesco Iannone
  • Giancarlo Di Gennaro
  • Alfredo D'Aniello
  • Edoardo Ferlazzo
  • Nazareno Gagliostro
  • Francesco Ursini
  • Paolo Bonanni
  • Nicola Paciello
  • Andrea Romigi
  • Umberto Aguglia
  • Giovambattista De Sarro
  • Emilio Russo
  • Antonio Gambardella
  • Angelo Labate
  • J. Neurol. Sci..2020 Aug;415:116903. S0022-510X(20)30240-9. doi: 10.1016/j.jns.2020.116903.Epub 2020-05-15.