冠状動脈性心疾患は、高血圧や糖尿病を伴わない患者の非アルコール性脂肪性肝疾患と関連している

Coronary heart disease is associated with nonalcoholic fatty liver disease in patients without hypertension and diabetes.

• Zipeng Liu
• Rufeng Wei
• Yan Li

抄録

本研究は，高血圧・糖尿病を伴わない患者を対象に，冠動脈性心疾患（CHD）と非アルコール性脂肪性肝疾患（NAFLD）との関連を，CHDの予測に焦点を当てて検討することを目的としたものである．CHDが疑われた高血圧・糖尿病を伴わない患者78名を連続して冠動脈造影（CAG）またはコンピュータ断層撮影（CT）を受けた．GensiniスコアはCHD群のCAG結果に基づいて計算した。CHDとGensiniスコアは、V1、V2、NAFLDと有意に相関していた。NAFLDのグレードが上がるにつれてGensiniスコアは上昇した。交絡因子を補正した後、NAFLD（B"Zs_200A"="Zs_200A"2.474、P"Zs_200A"<"Zs_200A".001、95％信頼区間。3.32-42.406）とコレステロール（B"Zs_200A"="Zs_200A"1.176、P"Zs_200A"="Zs_200A"0.025、95%信頼区間：1.155-9.101）がCHDの予測因子であった。高血圧や糖尿病のない患者では、高悪性度NAFLDがCHDのリスクを予測する可能性がある。

This study was performed to explore the relationship between coronary heart disease (CHD) and nonalcoholic fatty liver disease (NAFLD) in patients without hypertension and diabetes with a focus on predicting CHD.In total, 78 consecutive patients without hypertension and diabetes who were suspected of CHD underwent coronary angiography (CAG) or computed tomography CAG. They were segregated into the CHD and non-CHD group according to the CAG or computed tomography angiography results. The Gensini score was calculated based on CAG results in the CHD group. All patients underwent ultrasonographic measurement of the liver, subcutaneous fat, and visceral fat thickness.The CHD and the Gensini score were significantly correlated with V1, V2, and NAFLD. As the grade of NAFLD increases, the Gensini score was increased. After correcting for confounding factors, NAFLD (B = 2.474, P < .001, 95% confidence interval: 3.32-42.406) and cholesterol (B = 1.176, P = 0.025, 95% confidence interval: 1.155-9.101) were predictor for CHD.The CHD is associated with NAFLD in the patients without hypertension and diabetes. The high-grade NAFLD may be predicted the risk of CHD in patients without hypertension and diabetes.