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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

横隔膜NMJの神経筋接合部の神経支配はsGC/cGMPシグナルによって制御されているか?

Is Innervation of the Neuromuscular Junction at the Diaphragm Modulated by sGC/cGMP Signaling?
  • Nadežda Lukáčová
  • L'udmila Hricová
  • Alexandra Kisucká
  • Štefánia Papcunová
  • Katarína Bimbová
  • Mária Bačová
  • Jaroslav Pavel
  • Martin Marsala
  • Ivo Vanický
  • Zuzana Dzurjašková
  • Stanislav Matéffy
  • Viktória Lukáčová
  • Andrea Stropkovská
  • Ján Gálik
  • Front Physiol.2020;11:700. doi: 10.3389/fphys.2020.00700.Epub 2020-06-23.

識別とメラノーマ関連網膜症患者の血清からの新規 TRPM1 自己抗体の特徴付け

Identification and characterization of novel TRPM1 autoantibodies from serum of patients with melanoma-associated retinopathy.
  • Juliette Varin
  • Margaret M Reynolds
  • Nassima Bouzidi
  • Sarah Tick
  • Juliette Wohlschlegel
  • Ondine Becquart
  • Christelle Michiels
  • Olivier Dereure
  • Robert M Duvoisin
  • Catherine W Morgans
  • José-Alain Sahel
  • Quentin Samaran
  • Bernard Guillot
  • José S Pulido
  • Isabelle Audo
  • Christina Zeitz
  • PLoS ONE.2020;15(4):e0231750. PONE-D-19-30946. doi: 10.1371/journal.pone.0231750.Epub 2020-04-23.

核磁気共鳴イメージングによる癌の生体分布の可視化のためのペプチド・トランスポーター標的化Fdipeptidesの有用性の可能性

Possible utility of peptide-transporter-targeting [F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging.
  • Hiroshi Arakawa
  • Hiroyuki Yamada
  • Kazutaka Arai
  • Takumi Kawanishi
  • Nobuhiro Nitta
  • Sayaka Shibata
  • Eiko Matsumoto
  • Kentaro Yano
  • Yukio Kato
  • Takuya Kumamoto
  • Ichio Aoki
  • Takuo Ogihara
  • Int J Pharm.2020 Jul;586:119575. S0378-5173(20)30559-7. doi: 10.1016/j.ijpharm.2020.119575.Epub 2020-07-02.

スポーツ傷害研究における方法に関する声明 第1回METHODS MATTER会議、コペンハーゲン、2019年より

Statement on Methods in Sport Injury Research From the First METHODS MATTER Meeting, Copenhagen, 2019.
  • Rasmus Østergaard Nielsen
  • Ian Shrier
  • Martí Casals
  • Alberto Nettel-Aguirre
  • Merete Møller
  • Caroline Bolling
  • Nataliá F N Bittencourt
  • Ben Clarsen
  • Niels Wedderkopp
  • Torbjørn Soligard
  • Toomas Timpka
  • Carolyn A Emery
  • Roald Bahr
  • Jenny Jacobsson
  • Rod Whiteley
  • Örjan Dahlström
  • Nicol van Dyk
  • Babette M Pluim
  • Emmanuel Stamatakis
  • Luz Palacios-Derflingher
  • Morten W Fagerland
  • Karim M Khan
  • Clare L Ardern
  • Evert Verhagen
  • J Orthop Sports Phys Ther.2020 May;50(5):226-233. doi: 10.2519/jospt.2020.9876.

WRKY55転写因子は、シロイヌナズナの活性酸素とサリチル酸の生合成に関与する遺伝子の転写を調節することで、葉の老化と防御応答を正に制御している

WRKY55 transcription factor positively regulates leaf senescence and defense response through modulating the transcription of genes implicated in ROS and SA biosynthesis in Arabidopsis.
  • Yiqiao Wang
  • Xing Cui
  • Bo Yang
  • Shutao Xu
  • Xiangyan Wei
  • Peiyu Zhao
  • Fangfang Niu
  • Mengting Sun
  • Chen Wang
  • Hao Cheng
  • Yuan-Qing Jiang
  • Development.2020 Jul;dev.189647. doi: 10.1242/dev.189647.Epub 2020-07-17.

メトホルミン塩酸塩の徐放性を制御して線維化を緩和し、創傷治癒を促進するための二重機能を持つ3層構造の足場の設計、作製、最適化

Design, fabrication, and optimization of a dual function three-layer scaffold for controlled release of metformin hydrochloride to alleviate fibrosis and accelerate wound healing.
  • Faraz Chogan
  • Tahereh Mirmajidi
  • Ali Hossein Rezayan
  • Ali Mohammad Sharifi
  • Aziz Ghahary
  • Jhamak Nourmohammadi
  • Amir Kamali
  • Mahdi Rahaie
  • Acta Biomater.2020 Jun;S1742-7061(20)30361-5. doi: 10.1016/j.actbio.2020.06.031.Epub 2020-06-23.

nCOVID-19の免疫病態と、効果的な治療と死亡者数の減少のための抗炎症・抗ウイルスプロスタグランジン(PG J)を含む宿主指示療法の可能性

Immuno-pathogenesis of nCOVID-19 and a possible host-directed therapy including anti-inflammatory and anti-viral prostaglandin (PG J) for effective treatment and reduction in the death toll.
  • Shakeel Shahzad
  • Mark Willcox
  • Med. Hypotheses.2020 Jul;143:110080. S0306-9877(20)31926-5. doi: 10.1016/j.mehy.2020.110080.Epub 2020-07-08.

麹菌のクロロフィル生合成と初期葉緑体発生を制御する黄色蛍光遺伝子の特性評価とファインマップの作成

Characterization and Fine Mapping of a Yellow-Virescent Gene Regulating Chlorophyll Biosynthesis and Early Stage Chloroplast Development in .
  • Chuanji Zhao
  • Lijiang Liu
  • Luqman Bin Safdar
  • Meili Xie
  • Xiaohui Cheng
  • Yueying Liu
  • Yang Xiang
  • Chaobo Tong
  • Jinxing Tu
  • Junyan Huang
  • Shengyi Liu
  • G3 (Bethesda).2020 Jul;g3.401460.2020. doi: 10.1534/g3.120.401460.Epub 2020-07-09.

軟骨石灰化は、膝関節の組織学的変性と関連している:非常に普及している、年齢に依存しない全身性のプロセス

Cartilage calcification is associated with histological degeneration of the knee joint: a highly prevalent, age-independent systemic process.
  • Jan Hubert
  • Frank Timo Beil
  • Tim Rolvien
  • Sebastian Butscheidt
  • Sandra Hischke
  • Klaus Püschel
  • Stephan Frosch
  • Haider Mussawy
  • Christian Ries
  • Thelonius Hawellek
  • Osteoarthr. Cartil..2020 Jul;S1063-4584(20)31063-3. doi: 10.1016/j.joca.2020.04.020.Epub 2020-07-16.

市販のホエイ製品は、細菌性エンドトキシン・リポ多糖類(LPS)誘発炎症をin vitroで抑制するグリコマクロペプチド強化活性を有し、腸管バリア機能を促進する

Commercial whey products promote intestinal barrier function with glycomacropeptide enhanced activity in downregulating bacterial endotoxin lipopolysaccharides (LPS)-induced inflammation in vitro.
  • Shirley Arbizu
  • Boon Chew
  • Susanne U Mertens-Talcott
  • Giuliana Noratto
  • Food Funct.2020 Jul;doi: 10.1039/d0fo00487a.Epub 2020-07-07.

ジペプチジルペプチダーゼ-4阻害薬シタグリプチンは、KvチャネルとPKAの活性化を介して血管弛緩を誘導する

Dipeptidyl peptidase-4 inhibitor sitagliptin induces vasorelaxation via the activation of Kv channels and PKA.
  • Hongliang Li
  • Mi Seon Seo
  • Jin Ryeol An
  • Hee Seok Jung
  • Kwon-Soo Ha
  • Eun-Taek Han
  • Seok-Ho Hong
  • Young Min Bae
  • Sung Hun Na
  • Won Sun Park
  • Toxicol. Appl. Pharmacol..2019 12;384:114799. S0041-008X(19)30407-7. doi: 10.1016/j.taap.2019.114799.Epub 2019-10-31.

ペメトレキセド化学療法が患者肺由来腫瘍異種移植(PDX)マウスモデルの腸内マイクロバイオータおよび腸内炎症に及ぼす影響

Impact of pemetrexed chemotherapy on the gut microbiota and intestinal inflammation of patient-lung-derived tumor xenograft (PDX) mouse models.
  • Cindy Pensec
  • Florence Gillaizeau
  • Dominique Guenot
  • Anne Bessard
  • Thomas Carton
  • Sébastien Leuillet
  • Mario Campone
  • Michel Neunlist
  • Hervé M Blottière
  • Françoise Le Vacon
  • Sci Rep.2020 Jun;10(1):9094. 10.1038/s41598-020-65792-6. doi: 10.1038/s41598-020-65792-6.Epub 2020-06-04.

新規抗がん剤として期待されるフェニルクロルメチン-キナゾリン誘導体の合成、Sirt1/caspase3シグナル伝達経路を介して肝細胞がんのアポトーシスを誘導した

Synthesis of a New Phenyl Chlormethine-Quinazoline Derivative, a Potential Anti-Cancer Agent, Induced Apoptosis in Hepatocellular Carcinoma Through Mediating Sirt1/Caspase 3 Signaling Pathway.
  • Jia-Jia Lv
  • Wen-Ting Song
  • Xin-Min Li
  • Jian-Mei Gao
  • Ze-Li Yuan
  • Front Pharmacol.2020;11:911. doi: 10.3389/fphar.2020.00911.Epub 2020-06-26.

低リスクの小児急性骨髄性白血病における良好な転帰を維持しつつ、アントラサイクリンの累積曝露を減らす戦略

A strategy to reduce cumulative anthracycline exposure in low-risk pediatric acute myeloid leukemia while maintaining favorable outcomes.
  • Himalee S Sabnis
  • Katherine A Minson
  • Caitlin Monroe
  • Kristen Allen
  • Jonathan L Metts
  • Todd M Cooper
  • William G Woods
  • Sharon M Castellino
  • Frank G Keller
  • Leuk. Res..2020 Jul;96:106421. S0145-2126(20)30126-0. doi: 10.1016/j.leukres.2020.106421.Epub 2020-07-12.

タンパク質ネットワーク解析により、AECOPD患者の血小板脱顆粒、タンパク質分解、コレステロール代謝経路に関与するタンパク質のレベルの変化が明らかになった

Protein Network Analysis Identifies Changes in the Level of Proteins Involved in Platelet Degranulation, Proteolysis and Cholesterol Metabolism Pathways in AECOPD Patients.
  • Dino B A Tan
  • Jason Ito
  • Kirsten Peters
  • Andreja Livk
  • Richard J Lipscombe
  • Tammy M Casey
  • Yuben P Moodley
  • COPD.2020 Feb;17(1):29-33. doi: 10.1080/15412555.2019.1711035.Epub 2020-01-10.

また、トリソミー21脳内オルガノイドの患者特異的アルツハイマー様病態を明らかにし、BACE2がヒト脳内のADサプレッサー遺伝子であることを明らかにした

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
  • Ivan Alić
  • Pollyanna A Goh
  • Aoife Murray
  • Erik Portelius
  • Eleni Gkanatsiou
  • Gillian Gough
  • Kin Y Mok
  • David Koschut
  • Reinhard Brunmeir
  • Yee Jie Yeap
  • Niamh L O'Brien
  • Jürgen Groet
  • Xiaowei Shao
  • Steven Havlicek
  • N Ray Dunn
  • Hlin Kvartsberg
  • Gunnar Brinkmalm
  • Rosalyn Hithersay
  • Carla Startin
  • Sarah Hamburg
  • Margaret Phillips
  • Konstantin Pervushin
  • Mark Turmaine
  • David Wallon
  • Anne Rovelet-Lecrux
  • Hilkka Soininen
  • Emanuela Volpi
  • Joanne E Martin
  • Jia Nee Foo
  • David L Becker
  • Agueda Rostagno
  • Jorge Ghiso
  • Željka Krsnik
  • Goran Šimić
  • Ivica Kostović
  • Dinko Mitrečić
  • Paul T Francis
  • Kaj Blennow
  • Andre Strydom
  • John Hardy
  • Henrik Zetterberg
  • Dean Nižetić
  • Mol. Psychiatry.2020 Jul;10.1038/s41380-020-0806-5. doi: 10.1038/s41380-020-0806-5.Epub 2020-07-10.

再生不良性貧血に対するアンドロゲンステロイドの長期投与に伴う多発性肝細胞腺腫。症例報告と文献レビュー

Multiple hepatocellular adenomas associated with long-term administration of androgenic steroids for aplastic anemia: A case report and literature review.
  • Lixia Wang
  • Cong Wang
  • Wei Li
  • Fanyang Meng
  • Yuying Li
  • Hongqiong Fan
  • Yanhua Zhou
  • Gnana Bharathi
  • Sujun Gao
  • Yan Yang
  • Medicine (Baltimore).2020 Jul;99(28):e20829. 00005792-202007100-00027. doi: 10.1097/MD.0000000000020829.

単一カラムクロマトグラフィー分離とSF-ICP-MS分析を組み合わせた中分解能モードでの河川水中のラジウム226の簡易かつ高感度測定

Simple and sensitive determination of radium-226 in river water by single column-chromatographic separation coupled to SF-ICP-MS analysis in medium resolution mode.
  • Guosheng Yang
  • Jian Zheng
  • Keiko Tagami
  • Shigeo Uchida
  • Jing Zhang
  • Jinlong Wang
  • Jinzhou Du
  • J Environ Radioact.2020 Sep;220-221:106305. S0265-931X(20)30178-8. doi: 10.1016/j.jenvrad.2020.106305.Epub 2020-05-25.

特定の有機炭素源を用いた石油生産に伴うTENORMスケール廃棄物中のラジウム同位体溶解の速度論とメカニズム:乳酸溶液を用いたケーススタディ

Kinetics and mechanism of radium-isotopes dissolution in TENORM scale waste associated with petroleum production using certain organic carbon source: lactic acid solution-case study.
  • Elsayed M El Afifi
  • Ahmed M Shahr El-Din
  • Moustafa A Hilal
  • Environ Sci Pollut Res Int.2020 Jul;10.1007/s11356-020-09863-1. doi: 10.1007/s11356-020-09863-1.Epub 2020-07-03.

また、重症硫黄マスタード眼損傷者の涙および血清MMP-9および血清TIMPsレベルを評価した

Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients.
  • Hassan Ghasemi
  • Roya Yaraee
  • Soghrat Faghihzadeh
  • Mohammad Ghassemi-Broumand
  • Mahmoud Mahmoudi
  • Mahmoud Babaei
  • Mostafa Naderi
  • Maliheh Safavi
  • Zeinab Ghazanfari
  • Maryam Rastin
  • Shahrzad Zamani
  • Nafiseh Tabasi
  • Elham Faghihzadeh
  • Reza Gharebaghi
  • Zuhair Mohammad Hassan
  • Ensie Sadat Mirsharif
  • Tooba Ghazanfari
  • Int. Immunopharmacol..2019 Dec;77:105812. S1567-5769(19)31188-9. doi: 10.1016/j.intimp.2019.105812.Epub 2019-10-31.

葉緑体のカリウム流出防止因子は、それぞれ光合成に影響を与え、短日光環境下での完全に発達したシロイヌナズナのロゼットの成長にも影響を与えている

Each of the chloroplast potassium efflux antiporters affects photosynthesis and growth of fully developed Arabidopsis rosettes under short-day photoperiod.
  • Somnath Dana
  • Andrei Herdean
  • Björn Lundin
  • Cornelia Spetea
  • Physiol Plant.2016 Dec;158(4):483-491. doi: 10.1111/ppl.12452.Epub 2016-06-09.

Erv14カーゴ受容体は酵母の耐塩性に関与しており、その相互作用は膜上のNha1カチオン/プロトンアンチポーターとの相互作用を介しています

Erv14 cargo receptor participates in yeast salt tolerance via its interaction with the plasma-membrane Nha1 cation/proton antiporter.
  • Paul Rosas-Santiago
  • Olga Zimmermannova
  • Rosario Vera-Estrella
  • Hana Sychrová
  • Omar Pantoja
  • Biochim. Biophys. Acta.2016 Jan;1858(1):67-74. S0005-2736(15)00328-4. doi: 10.1016/j.bbamem.2015.09.024.Epub 2015-10-09.

TheraP:進行性転移性去勢抵抗性前立腺がんを対象としたLu-PSMA-617セラノシス治療 vs カバジタキセルの無作為化第2相試験(Clinical Trial Protocol ANZUP 1603)

TheraP: a randomized phase 2 trial of Lu-PSMA-617 theranostic treatment vs cabazitaxel in progressive metastatic castration-resistant prostate cancer (Clinical Trial Protocol ANZUP 1603).
  • Michael S Hofman
  • Louise Emmett
  • John Violet
  • Alison Y Zhang
  • Nicola J Lawrence
  • Martin Stockler
  • Roslyn J Francis
  • Amir Iravani
  • Scott Williams
  • Arun Azad
  • Andrew Martin
  • Margaret McJannett
  • Ian D Davis
  • BJU Int..2019 11;124 Suppl 1:5-13. doi: 10.1111/bju.14876.Epub 2019-10-22.

mTORの阻害は、実験的な虚脱性局所セグメント糸球体硬化症を遅らせるが、予防することはできなかった

Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis.
  • Laura Miesen
  • Jennifer Eymael
  • Shagun Sharma
  • Markus A Loeven
  • Brigith Willemsen
  • Marinka Bakker-van Bebber
  • Fieke Mooren
  • Catherine Meyer-Schwesinger
  • Henry Dijkman
  • Jack F M Wetzels
  • Jitske Jansen
  • Johan van der Vlag
  • Bart Smeets
  • Sci Rep.2020 May;10(1):8580. 10.1038/s41598-020-65352-y. doi: 10.1038/s41598-020-65352-y.Epub 2020-05-22.

植物由来の生物活性物質の抗がん作用の可能性についての洞察。前立腺癌に焦点を当てる

Insights on the anticancer potential of plant-food bioactives: A key focus to prostate cancer.
  • Bahare Salehi
  • Patrick Valere Tsouh Fokou
  • Lauve Rachel Tchokouaha Yamthe
  • Brice Tchatat Tali
  • Charles Oluwaseun Adetunji
  • Amirhossein Rahavian
  • Fhatuwani Nixwell Mudau
  • Natália Martins
  • Miquel Martorell
  • Célia F Rodrigues
  • William N Setzer
  • Mehdi Sharifi-Rad
  • Ryszard Amarowicz
  • Javad Sharifi-Rad
  • Cell. Mol. Biol. (Noisy-le-grand).2020 Jun;66(4):250-263. Epub 2020-06-25.

非虚血性心筋症における心室頻拍アブレーション後の長期成績。晩期の電位廃止とVT非誘導性

Long-Term Outcome after Ventricular Tachycardia Ablation in Non-Ischemic Cardiomyopathy: Late Potential Abolition and VT Noninducibility.
  • Kenji Okubo
  • Lorenzo Gigli
  • Nicola Trevisi
  • Luca Foppoli
  • Andrea Radinovic
  • Caterina Bisceglia
  • Antonio Frontera
  • Giuseppe D'Angelo
  • Manuela Cireddu
  • Gabriele Paglino
  • Patrizio Mazzone
  • Paolo Della Bella
  • Circ Arrhythm Electrophysiol.2020 Jul;doi: 10.1161/CIRCEP.119.008307.Epub 2020-07-12.

Circular RNA 406961はILF2と相互作用し、STAT3/JNK経路の活性化を介してヒト気管支上皮細胞におけるPM誘導性炎症反応を調節する

Circular RNA 406961 interacts with ILF2 to regulate PM-induced inflammatory responses in human bronchial epithelial cells via activation of STAT3/JNK pathways.
  • Yangyang Jia
  • Xin Li
  • Aruo Nan
  • Nan Zhang
  • Lijian Chen
  • Hanyu Zhou
  • Han Zhang
  • Miaoyun Qiu
  • Jialu Zhu
  • Yihui Ling
  • Yiguo Jiang
  • Environ Int.2020 Aug;141:105755. S0160-4120(19)33945-5. doi: 10.1016/j.envint.2020.105755.Epub 2020-05-07.

研究のための角膜提供と移植のための角膜提供。フランスの大学病院における受け入れ率の1年間のプロスペクティブ研究

Corneal donation for research versus for transplantation: A-year prospective study of acceptance rates in a French University Hospital.
  • Thibaud Garcin
  • Jean Loup Pugniet
  • Thierry Peyragrosse
  • Francoise Rogues
  • Sophie Acquart
  • Fabrice Cognasse
  • Gilles Thuret
  • Philippe Gain
  • PLoS ONE.2020;15(5):e0233392. PONE-D-19-35417. doi: 10.1371/journal.pone.0233392.Epub 2020-05-21.

1 型糖尿病の青年および若年成人における血糖コントロールに対する持続的血糖モニタリングの効果。無作為化臨床試験

Effect of Continuous Glucose Monitoring on Glycemic Control in Adolescents and Young Adults With Type 1 Diabetes: A Randomized Clinical Trial.
  • Lori M Laffel
  • Lauren G Kanapka
  • Roy W Beck
  • Katherine Bergamo
  • Mark A Clements
  • Amy Criego
  • Daniel J DeSalvo
  • Robin Goland
  • Korey Hood
  • David Liljenquist
  • Laurel H Messer
  • Roshanak Monzavi
  • Thomas J Mouse
  • Priya Prahalad
  • Jennifer Sherr
  • Jill H Simmons
  • R Paul Wadwa
  • Ruth S Weinstock
  • Steven M Willi
  • Kellee M Miller
  • JAMA.2020 06;323(23):2388-2396. 2767160. doi: 10.1001/jama.2020.6940.

デュシェンヌ型筋ジストロフィーを持つ小児におけるrAAVrh74.MHCK7.マイクロジストロフィンの全身投与の評価。非ランダム化対照試験

Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial.
  • Jerry R Mendell
  • Zarife Sahenk
  • Kelly Lehman
  • Carrie Nease
  • Linda P Lowes
  • Natalie F Miller
  • Megan A Iammarino
  • Lindsay N Alfano
  • Amanda Nicholl
  • Samiah Al-Zaidy
  • Sarah Lewis
  • Kathleen Church
  • Richard Shell
  • Linda H Cripe
  • Rachael A Potter
  • Danielle A Griffin
  • Eric Pozsgai
  • Ashish Dugar
  • Mark Hogan
  • Louise R Rodino-Klapac
  • JAMA Neurol.2020 Jun;2767086. doi: 10.1001/jamaneurol.2020.1484.Epub 2020-06-15.

ナイアシンアミドの最適化された低pH製剤は、ヒト表皮ケラチノサイトにおけるオートファジーマーカーATG5遺伝子の発現とタンパク質レベルの誘導を増強する

Optimized low pH formulation of niacinamide enhances induction of autophagy marker ATG5 gene expression and protein levels in human epidermal keratinocytes.
  • J E Oblong
  • Y M DeAngelis
  • B B Jarrold
  • J C Bierman
  • H A Rovito
  • L Vires
  • B Fang
  • T Laughlin
  • W Zhao
  • S M Hartman
  • R Kainkaryam
  • R Adams
  • J D Sherrill
  • T Hakozaki
  • J Eur Acad Dermatol Venereol.2020 Jun;34 Suppl 3:3-11. doi: 10.1111/jdv.16582.

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