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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

固形腫瘍患者に対するデュルバルマブとトレメリムマブの併用療法とデュルバルマブまたはトレメリムマブ単剤療法との比較。システマティックレビューおよびメタアナリシス

Durvalumab and tremelimumab combination therapy versus durvalumab or tremelimumab monotherapy for patients with solid tumors: A systematic review and meta-analysis.
  • Bi-Cheng Wang
  • Peng-Cheng Li
  • Ji-Quan Fan
  • Guo-He Lin
  • Quentin Liu
  • Medicine (Baltimore).2020 Jul;99(28):e21273. 00005792-202007100-00133. doi: 10.1097/MD.0000000000021273.

新しいアプローチ法を用いてナノ材料の皮膚感作性を調査するための有害事象パスウェイ(AOP)の枠組 みを適用した

Application of the adverse outcome pathway (AOP) framework for investigating skin sensitization potential of nanomaterials using new approach methods.
  • Soraia Ferreira Bezerra
  • Bruna Dos Santos Rodrigues
  • Artur Christian Garcia da Silva
  • Renato Ivan de Ávila
  • Hallison Ranieri Gonçalves Brito
  • Emílio Ramos Cintra
  • Danillo Fabrini Maciel Costa Veloso
  • Eliana Martins Lima
  • Marize Campos Valadares
  • Contact Derm..2020 Jul;doi: 10.1111/cod.13669.Epub 2020-07-19.

股関節全置換術後の遅発性無菌性合併症と敗血症性合併症の鑑別のためのマルチディテクターCTの価値

Value of multidetector computed tomography for the differentiation of delayed aseptic and septic complications after total hip arthroplasty.
  • Jaime Isern-Kebschull
  • Xavier Tomas
  • Ana Isabel García-Díez
  • Laura Morata
  • Ignacio Moya
  • José Ríos
  • Alex Soriano
  • Skeletal Radiol..2020 Jun;49(6):893-902. 10.1007/s00256-019-03355-1. doi: 10.1007/s00256-019-03355-1.Epub 2020-01-03.

地中海式ダイエットのアドヒアランスに対する社会経済的および環境的決定要因の影響:ギリシャ、アテネ都市圏における自治体レベルの空間分析

The impact of socioeconomic and environmental determinants on Mediterranean diet adherence: a municipal-level spatial analysis in Athens metropolitan area, Greece.
  • Thomas Tsiampalis
  • Antigoni Faka
  • Matina Kouvari
  • Theodora Psaltopoulou
  • Christos Pitsavos
  • Christos Chalkias
  • Demosthenes B Panagiotakos
  • Int J Food Sci Nutr.2020 Jul;:1-12. doi: 10.1080/09637486.2020.1791057.Epub 2020-07-12.

ニコチンアミドは、ラットのフルクトース誘発性メタボリックシンドロームにおいて、コリン作動系を介して炎症や酸化ストレスを軽減します

Nicotinamide reduces inflammation and oxidative stress via the cholinergic system in fructose-induced metabolic syndrome in rats.
  • J D Villeda-González
  • J L Gómez-Olivares
  • L A Baiza-Gutman
  • L Manuel-Apolinar
  • L Damasio-Santana
  • C Millán-Pacheco
  • S Ángeles-Mejía
  • M C Cortés-Ginez
  • M Cruz-López
  • C J Vidal-Moreno
  • M Díaz-Flores
  • Life Sci..2020 Jun;250:117585. S0024-3205(20)30333-7. doi: 10.1016/j.lfs.2020.117585.Epub 2020-03-31.

HPV 陽性口腔咽頭扁平上皮癌を有する女性におけるヒトパピローマウイルス関連性生殖器病理

Human Papillomavirus-Associated Anogenital Pathology in Females With HPV-Positive Oropharyngeal Squamous Cell Carcinoma.
  • Alyssa Larish
  • Linda Yin
  • Gretchen Glaser
  • Eric Moore
  • Jamie Bakkum-Gamez
  • David Routman
  • Daniel Ma
  • Daniel Price
  • Jeffrey Janus
  • Katharine Price
  • Ashish Chintakuntlawar
  • Michelle Neben-Wittich
  • Robert Foote
  • Kathryn Van Abel
  • Otolaryngol Head Neck Surg.2020 Jul;:194599820941499. doi: 10.1177/0194599820941499.Epub 2020-07-14.

膵臓癌治療のための細胞毒性リガンドをアンカーとするナチュラルキラー細胞の再誘導を合理的に設計した

Rationally designed redirection of natural killer cells anchoring a cytotoxic ligand for pancreatic cancer treatment.
  • Young Eun Lee
  • Anna Ju
  • Hwi Wan Choi
  • Jin-Chul Kim
  • Eunice EunKyeong Kim
  • Tae Sung Kim
  • Hyo Jeong Kang
  • Sang-Yeob Kim
  • Jin-Young Jang
  • Ja-Lok Ku
  • Song Cheol Kim
  • Eunsung Jun
  • Mihue Jang
  • J Control Release.2020 Jul;S0168-3659(20)30398-9. doi: 10.1016/j.jconrel.2020.07.016.Epub 2020-07-16.

非神経性表面外胚葉ロゼット形成とF-アクチン動態が哺乳類神経管閉鎖を駆動することを明らかにした

Non-neural surface ectodermal rosette formation and F-actin dynamics drive mammalian neural tube closure.
  • Chengji J Zhou
  • Yu Ji
  • Kurt Reynolds
  • Moira McMahon
  • Michael A Garland
  • Shuwen Zhang
  • Bo Sun
  • Ran Gu
  • Mohammad Islam
  • Yue Liu
  • Tianyu Zhao
  • Grace Hsu
  • Janet Iwasa
  • Biochem. Biophys. Res. Commun..2020 Jun;526(3):647-653. S0006-291X(20)30635-5. doi: 10.1016/j.bbrc.2020.03.138.Epub 2020-04-02.

ナイーブなヒトESCにおける自家分泌FGFシグナルによる不均一性を克服することで、ランダムX染色体不活性化のモデル化が可能となる

Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation.
  • Chenrui An
  • Guihai Feng
  • Jixiang Zhang
  • Shiwei Cao
  • Ying Wang
  • Nannan Wang
  • Falong Lu
  • Qi Zhou
  • Haoyi Wang
  • Cell Stem Cell.2020 Jul;S1934-5909(20)30269-1. doi: 10.1016/j.stem.2020.06.002.Epub 2020-07-08.

従属栄養性硝化-好気性脱窒が可能な新規リン酸蓄積生物Arthrobacter sp.HHEP5によるリン・窒素除去安全性評価、除去特性評価、機構解明、排水処理

Phosphorus and nitrogen removal by a novel phosphate-accumulating organism, Arthrobacter sp. HHEP5 capable of heterotrophic nitrification-aerobic denitrification: Safety assessment, removal characterization, mechanism exploration and wastewater treatment.
  • Mengyu Zhang
  • Luqing Pan
  • Liping Liu
  • Chen Su
  • Le Dou
  • Zhaopeng Su
  • Ziyan He
  • Bioresour. Technol..2020 Sep;312:123633. S0960-8524(20)30905-6. doi: 10.1016/j.biortech.2020.123633.Epub 2020-06-04.

腫瘍内遺伝的異質性を有する膠芽腫の機能的に異なる相互作用を有するがん細胞サブ集団の同定

Identification of functionally distinct and interacting cancer cell subpopulations from glioblastoma with intratumoral genetic heterogeneity.
  • Min Guo
  • Marjolein van Vliet
  • Jian Zhao
  • Teresita Díaz de Ståhl
  • Mikael S Lindström
  • Huaitao Cheng
  • Susanne Heller
  • Monica Nistér
  • Daniel Hägerstrand
  • Neurooncol Adv.2020 Jan-Dec;2(1):vdaa061. vdaa061. doi: 10.1093/noajnl/vdaa061.Epub 2020-05-27.

血漿性ホルモン濃度の縦断的変化は、10年間の日系男性におけるCT測定による局所的な脂肪率の変化と相関している

Longitudinal changes in plasma sex hormone concentrations correlate with changes in CT-measured regional adiposity among Japanese American men over 10 years.
  • Kathryn T Dinh
  • John K Amory
  • Alvin M Matsumoto
  • Brett T Marck
  • Wilfred Y Fujimoto
  • Donna L Leonetti
  • Edward J Boyko
  • Stephanie T Page
  • Katya B Rubinow
  • Clin. Endocrinol. (Oxf).2020 Jul;doi: 10.1111/cen.14278.Epub 2020-07-07.

Epichloë festucae由来の核タンパク質NsiAは、MAPキナーゼMpkBと相互作用し、共生感染や菌糸体融合に必要な遺伝子の発現を制御していることが明らかになった

A nuclear protein NsiA from Epichloë festucae interacts with a MAP kinase MpkB and regulates the expression of genes required for symbiotic infection and hyphal cell fusion.
  • Aiko Tanaka
  • Shota Kamiya
  • Yoshino Ozaki
  • Shinichi Kameoka
  • Yuka Kayano
  • Saikia Sanjay
  • Fumitake Akano
  • Aiko Uemura
  • Hiroki Takagi
  • Ryohei Terauchi
  • Jun-Ichi Maruyama
  • Hamzeh Haj Hammadeh
  • André Fleissner
  • Barry Scott
  • Daigo Takemoto
  • Mol. Microbiol..2020 Jul;doi: 10.1111/mmi.14568.Epub 2020-07-07.

ブラジルにおける大豆ルーパーChrysodeixis includens(Lepidoptera: Noctuidae)によるキチン合成阻害剤殺虫剤に対する圃場発生抵抗性

Field-evolved resistance to chitin synthesis inhibitor insecticides by soybean looper, Chrysodeixis includens (Lepidoptera: Noctuidae), in Brazil.
  • Regis F Stacke
  • Daniela N Godoy
  • Venicius E Pretto
  • Fábio M Führ
  • Patricia da S Gubiani
  • Bruna L Hettwer
  • Cínthia G Garlet
  • Junior C Somavilla
  • Dionei S Muraro
  • Oderlei Bernardi
  • Chemosphere.2020 Jun;259:127499. S0045-6535(20)31693-3. doi: 10.1016/j.chemosphere.2020.127499.Epub 2020-06-29.

線維筋異形成と線維筋異形成の遺伝学的研究、メタアナリシスと患者の臨床的特徴への影響。ARCADIA-POL試験

Genetic Study of and Fibromuscular Dysplasia, Meta-Analysis and Effects on Clinical Features of Patients: The ARCADIA-POL Study.
  • Ewa Warchol-Celinska
  • Takiy Berrandou
  • Aleksander Prejbisz
  • Adrien Georges
  • Delia Dupré
  • Magdalena Januszewicz
  • Elzbieta Florczak
  • Katarzyna Jozwik-Plebanek
  • Piotr Dobrowolski
  • Witold Smigielski
  • Wojciech Drygas
  • Jacek Kadziela
  • Adam Witkowski
  • Marek Kabat
  • Malgorzata Szczerbo-Trojanowska
  • Marco Pappaccogli
  • Alexandre Persu
  • Xavier Jeunemaitre
  • Andrzej Januszewicz
  • Nabila Bouatia-Naji
  • Hypertension.2020 Jul;76(1):e4-e7. doi: 10.1161/HYPERTENSIONAHA.120.14793.Epub 2020-06-01.

ANKRD26遺伝子の5'UTRの変異と骨髄性悪性腫瘍の素因を持つ遺伝性血小板減少症との関係。エジプトでの研究

Relation between mutations in the 5' UTR of ANKRD26 gene and inherited thrombocytopenia with predisposition to myeloid malignancies. An Egyptian study.
  • Nahla Ibrahim Zidan
  • Doaa Metwally AbdElmonem
  • Haitham Mohamed Elsheikh
  • Elsayed Anany Metwally
  • Wesam AbdElmonem Mokhtar
  • Gamal Mohamed Osman
  • Platelets.2020 Jul;:1-9. doi: 10.1080/09537104.2020.1790512.Epub 2020-07-13.

11beta-ヒドロキシステロイド脱水素酵素1型および2型は、コルチゾール分泌性副腎腺腫においてアップレギュレーションおよびダウンレギュレーションされている

11beta-Hydroxysteroid dehydrogenase types 1 and 2 are up- and downregulated in cortisol-secreting adrenal adenomas.
  • Giuseppina Mazzocchi
  • Ludwik K Malendowicz
  • Francesco Aragona
  • Cinzia Tortorella
  • Lucia Gottardo
  • Gastone G Nussdorfer
  • J. Investig. Med..2002 Jul;50(4):288-92. doi: 10.2310/6650.2002.33012.

急性アキレス腱損傷の治療と腱周囲癒着の予防を目的とした新しいコラーゲンベースの医療機器(ElastiCo®)の評価。インビトロでの生体適合性およびインビボでの調査

Evaluation of a new collagen-based medical device (ElastiCo®) for the treatment of acute Achilles tendon injury and prevention of peritendinous adhesions: An in vitro biocompatibility and in vivo investigation.
  • Francesca Veronesi
  • Gianluca Giavaresi
  • Davide Bellini
  • Veronica Casagranda
  • Daniele Pressato
  • Milena Fini
  • J Tissue Eng Regen Med.2020 Jun;doi: 10.1002/term.3085.Epub 2020-06-27.

抗生物質耐性メタロ-β-ラクタマーゼに対する阻害効果が期待されるトリアゾール系阻害剤の構造研究

Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases.
  • Zeeshan Muhammad
  • Susann Skagseth
  • Marc Boomgaren
  • Sundus Akhter
  • Christopher Fröhlich
  • Aya Ismael
  • Tony Christopeit
  • Annette Bayer
  • Hanna-Kirsti S Leiros
  • Bioorg. Med. Chem..2020 Aug;28(15):115598. S0968-0896(20)30428-4. doi: 10.1016/j.bmc.2020.115598.Epub 2020-06-18.

慢性腎臓病のステージを越えて心筋異常を定義します。心臓磁気共鳴画像研究

Defining Myocardial Abnormalities Across the Stages of Chronic Kidney Disease: A Cardiac Magnetic Resonance Imaging Study.
  • Manvir K Hayer
  • Ashwin Radhakrishnan
  • Anna M Price
  • Boyang Liu
  • Shanat Baig
  • Christopher J Weston
  • Luca Biasiolli
  • Charles J Ferro
  • Jonathan N Townend
  • Richard P Steeds
  • Nicola C Edwards
  • JACC Cardiovasc Imaging.2020 Jul;S1936-878X(20)30411-3. doi: 10.1016/j.jcmg.2020.04.021.Epub 2020-07-09.

肺疾患のトランスレーショナル研究における細胞を用いた治療法の動物モデルへの洞察自然発生性喘息の馬は正しい選択か?

Insights into animal models for cell-based therapies in translational studies of lung diseases: Is the horse with naturally occurring asthma the right choice?
  • Anna Lange-Consiglio
  • Luca Stucchi
  • Enrica Zucca
  • Jean Pierre Lavoie
  • Fausto Cremonesi
  • Francesco Ferrucci
  • Cytotherapy.2019 05;21(5):525-534. S1465-3249(19)30033-7. doi: 10.1016/j.jcyt.2019.02.010.Epub 2019-03-29.

マウスの実験的炎症性腸疾患におけるペニーロワイヤルフェノール抽出物による炎症と大腸障害の軽減

Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice.
  • João Rocha
  • Rosa Direito
  • Ana Lima
  • Joana Mota
  • Margarida Gonçalves
  • Maria Paula Duarte
  • João Solas
  • Bruno Felício Peniche
  • Adelaide Fernandes
  • Rui Pinto
  • Ricardo Boavida Ferreira
  • Bruno Sepodes
  • Maria-Eduardo Figueira
  • Biomed. Pharmacother..2019 Oct;118:109351. S0753-3322(19)32012-8. doi: 10.1016/j.biopha.2019.109351.Epub 2019-08-22.

腫瘍細胞表面付着性ペプチド-薬物複合体プロドラッグナノ粒子は、腫瘍の転移を抑制し、治療効果を増大させます

Tumor-Cell-Surface Adherable Peptide-Drug Conjugate Prodrug Nanoparticles Inhibit Tumor Metastasis and Augment Treatment Efficacy.
  • Chen Qian
  • Jingjing Wang
  • Ying Qian
  • Rongfeng Hu
  • Jiayu Zou
  • Chenqi Zhu
  • Yuan Zhu
  • Shuyang Qi
  • Xiaobin Jia
  • Li Wu
  • Weidong Li
  • Zhipeng Chen
  • Nano Lett..2020 Jun;20(6):4153-4161. doi: 10.1021/acs.nanolett.0c00152.Epub 2020-05-28.

下水汚泥の嫌気性消化物を肥料として使用したアルカリ性貧弱砂質土壌および泥炭基質上での施肥。トマトの生育および土壌性状に及ぼす影響

Anaerobic digestates from sewage sludge used as fertilizer on a poor alkaline sandy soil and on a peat substrate: Effects on tomato plants growth and on soil properties.
  • Giulio Cristina
  • Enrico Camelin
  • Tonia Tommasi
  • Debora Fino
  • Massimo Pugliese
  • J. Environ. Manage..2020 Sep;269:110767. S0301-4797(20)30699-X. doi: 10.1016/j.jenvman.2020.110767.Epub 2020-05-28.

セリン異化は呼吸が損なわれたときにNADHを供給します

Serine Catabolism Feeds NADH when Respiration Is Impaired.
  • Lifeng Yang
  • Juan Carlos Garcia Canaveras
  • Zihong Chen
  • Lin Wang
  • Lingfan Liang
  • Cholsoon Jang
  • Johannes A Mayr
  • Zhaoyue Zhang
  • Jonathan M Ghergurovich
  • Le Zhan
  • Shilpy Joshi
  • Zhixian Hu
  • Melanie R McReynolds
  • Xiaoyang Su
  • Eileen White
  • Raphael J Morscher
  • Joshua D Rabinowitz
  • Cell Metab..2020 Apr;31(4):809-821.e6. S1550-4131(20)30114-5. doi: 10.1016/j.cmet.2020.02.017.Epub 2020-03-17.

アポリポ蛋白AIとEは多発性硬化症における灰白質に対する神経軸索損傷と関連している

Apolipoproteins AI and E are associated with neuroaxonal injury to gray matter in multiple sclerosis.
  • Mason McComb
  • Robert Parambi
  • Richard W Browne
  • Mary Lou Bodziak
  • Dejan Jakimovski
  • Niels Bergsland
  • Aleksandra Maceski
  • Bianca Weinstock-Guttman
  • Jens Kuhle
  • Robert Zivadinov
  • Murali Ramanathan
  • Mult Scler Relat Disord.2020 Jul;45:102389. S2211-0348(20)30464-8. doi: 10.1016/j.msard.2020.102389.Epub 2020-07-11.

イタリア産発酵乳ギョードゥの微生物学的特性評価

Microbiological characterization of Gioddu, an Italian fermented milk.
  • Antonietta Maoloni
  • Giuseppe Blaiotta
  • Ilario Ferrocino
  • Nicoletta P Mangia
  • Andrea Osimani
  • Vesna Milanović
  • Federica Cardinali
  • Cristiana Cesaro
  • Cristiana Garofalo
  • Francesca Clementi
  • Marina Pasquini
  • Maria Federica Trombetta
  • Luca Cocolin
  • Lucia Aquilanti
  • Int. J. Food Microbiol..2020 Jun;323:108610. S0168-1605(20)30104-5. doi: 10.1016/j.ijfoodmicro.2020.108610.Epub 2020-03-20.

ニワトリ胚の生体内ラベリングによる第一心野と第二心野の組み込みと直腸心管の将来的な運命

Incorporation of the first and second heart fields and prospective fate of the straight heart tube via in vivo labeling of chicken embryos.
  • Villavicencio Guzmán Laura
  • Salazar García Marcela
  • Jaime Cruz Ricardo
  • Lazzarini Roberto
  • Toledano-Toledano Filiberto
  • Concepción Sánchez Gómez
  • PLoS ONE.2020;15(7):e0234069. PONE-D-19-25042. doi: 10.1371/journal.pone.0234069.Epub 2020-07-10.

ブラジル・リオデジャネイロ州に生息するグレイトトリガーフィッシュBalistes capriscus Gmelin, 1789とクイーントリガーフィッシュB. vetula Linnaeus, 1758 (Osteichthyes: Balistidae)のメタゾアン寄生の群集生態

Community ecology of the metazoan parasites of the grey triggerfish, Balistes capriscus Gmelin, 1789 and queen triggerfish B. vetula Linnaeus,1758 (Osteichthyes: Balistidae) from the State of Rio de Janeiro, Brazil.
  • Dimitri R Alves
  • Aline R Paraguassú
  • José L Luque
  • Rev Bras Parasitol Vet.2005 Apr-Jun;14(2):71-7.

カスパーゼ-8はアポトーシス、ネクロプトーシス、パイロプトーシスの分子スイッチである

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
  • Melanie Fritsch
  • Saskia D Günther
  • Robin Schwarzer
  • Marie-Christine Albert
  • Fabian Schorn
  • J Paul Werthenbach
  • Lars M Schiffmann
  • Neil Stair
  • Hannah Stocks
  • Jens M Seeger
  • Mohamed Lamkanfi
  • Martin Krönke
  • Manolis Pasparakis
  • Hamid Kashkar
  • Nature.2019 11;575(7784):683-687. 10.1038/s41586-019-1770-6. doi: 10.1038/s41586-019-1770-6.Epub 2019-11-20.

低酸素腫瘍の陽子線治療における生物学的に重み付けされた線量計算のためのOERモデルと結合したFLUKAモンテカルロコードを開発した

The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors.
  • Tordis Johnsen Dahle
  • Espen Rusten
  • Camilla Hanquist Stokkevåg
  • Antti Silvoniemi
  • Andrea Mairani
  • Lars Fredrik Fjæra
  • Eivind Rørvik
  • Helge Henjum
  • Pauliina Wright
  • Camilla Grindeland Boer
  • Sarita Forsback
  • Heikki Minn
  • Eirik Malinen
  • Kristian Smeland Ytre-Hauge
  • Phys Med.2020 Jul;76:166-172. S1120-1797(20)30163-0. doi: 10.1016/j.ejmp.2020.07.003.Epub 2020-07-16.

高血糖マウスおよび全球脳虚血・再灌流傷害マウスの海馬における柑橘類カワチバンカンの果皮およびオーラプテンの神経保護効果

[Neuroprotective effects of the peel of Citrus kawachiensis (Kawachi Bankan) and auraptene in the hippocampus of hyperglycemia mice and global cerebral ischemia/reperfusion injury mice].
  • Satoshi Okuyama
  • Atsushi Sawamoto
  • Mitsunari Nakajima
  • Yoshiko Furukawa
  • Nippon Yakurigaku Zasshi.2020;155(4):214-219. doi: 10.1254/fpj.20022.

神経保護作用と血管新生作用の相乗効果を有する桂皮酸誘導体の設計・合成・生物学的評価

Design, synthesis and biological evaluation of cinnamic acid derivatives with synergetic neuroprotection and angiogenesis effect.
  • Wen-Xi Zhang
  • Hui Wang
  • He-Rong Cui
  • Wen-Bo Guo
  • Fei Zhou
  • De-Sheng Cai
  • Bing Xu
  • Xiao-Hui Jia
  • Xue-Mei Huang
  • Yu-Qin Yang
  • Hong-Shan Chen
  • Jin-Chai Qi
  • Peng-Long Wang
  • Hai-Min Lei
  • Eur J Med Chem.2019 Dec;183:111695. S0223-5234(19)30845-1. doi: 10.1016/j.ejmech.2019.111695.Epub 2019-09-13.

Bacillus toyonensis COPE52は脂質・脂肪酸組成を修飾し、抗真菌活性を発揮し、塩分条件下でのトマト植物の生育を促進する

Bacillus toyonensis COPE52 Modifies Lipid and Fatty Acid Composition, Exhibits Antifungal Activity, and Stimulates Growth of Tomato Plants Under Saline Conditions.
  • Daniel Rojas-Solis
  • Miguel A Vences-Guzmán
  • Christian Sohlenkamp
  • Gustavo Santoyo
  • Curr. Microbiol..2020 Jun;10.1007/s00284-020-02069-1. doi: 10.1007/s00284-020-02069-1.Epub 2020-06-05.

糖尿病治療における絶食(FIT)試験:2型糖尿病患者における絶食を模倣した食事の断続的な使用の効果に関する無作為化、対照、評価者盲検介入試験のための研究プロトコル

Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes.
  • Elske L van den Burg
  • Marjolein P Schoonakker
  • Petra G van Peet
  • M Elske van den Akker-van Marle
  • Ko Willems van Dijk
  • Valter D Longo
  • Hildo J Lamb
  • Mattijs E Numans
  • Hanno Pijl
  • BMC Endocr Disord.2020 Jun;20(1):94. 10.1186/s12902-020-00576-7. doi: 10.1186/s12902-020-00576-7.Epub 2020-06-24.

ヒト歯髄におけるパルバルブミン、サブスタンスP、カルシトニン遺伝子関連ペプチド免疫陽性軸索は、静脈瘤の分布が異なる

Parvalbumin-, substance P- and calcitonin gene-related peptide-immunopositive axons in the human dental pulp differ in their distribution of varicosities.
  • Sook Kyung Park
  • Seung Ki Choi
  • Youn Gyung Kim
  • So Young Choi
  • Jin Wook Kim
  • Sang Hyeok Seo
  • Ji Hyun Lee
  • Yong Chul Bae
  • Sci Rep.2020 Jun;10(1):10672. 10.1038/s41598-020-67804-x. doi: 10.1038/s41598-020-67804-x.Epub 2020-06-30.

ネコノミゲノムの染色体レベルでのアセンブリーにより、遺伝子の重複とゲノムサイズの可塑性が明らかになった

A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity.
  • Timothy P Driscoll
  • Victoria I Verhoeve
  • Joseph J Gillespie
  • J Spencer Johnston
  • Mark L Guillotte
  • Kristen E Rennoll-Bankert
  • M Sayeedur Rahman
  • Darren Hagen
  • Christine G Elsik
  • Kevin R Macaluso
  • Abdu F Azad
  • BMC Biol..2020 Jun;18(1):70. 10.1186/s12915-020-00802-7. doi: 10.1186/s12915-020-00802-7.Epub 2020-06-19.

海藻Acanthophora spiciferaのバイオエンジニアリング金ナノ粒子の医薬用途への応用:抗酸化作用、抗菌作用、抗がん作用

Bioengineered gold nanoparticles from marine seaweed Acanthophora spicifera for pharmaceutical uses: antioxidant, antibacterial, and anticancer activities.
  • Baskaran Babu
  • Subramanian Palanisamy
  • Manoharan Vinosha
  • Ravichandran Anjali
  • Ponnuchamy Kumar
  • Boomi Pandi
  • Mehdi Tabarsa
  • SangGuan You
  • Narayanasamy Marimuthu Prabhu
  • Bioprocess Biosyst Eng.2020 Jul;10.1007/s00449-020-02408-3. doi: 10.1007/s00449-020-02408-3.Epub 2020-07-18.

ZENKER'S DIVERTICULUMに対するFLEXIBLE ENDOSCOPIC MYOTOMYの実践パターン、技術、および結果:レトロスペクティブ、多施設研究

PRACTICE PATTERNS, TECHNIQUES, AND OUTCOMES OF FLEXIBLE ENDOSCOPIC MYOTOMY FOR ZENKER'S DIVERTICULUM: RETROSPECTIVE, MULTI-CENTER STUDY.
  • Chetan Mittal
  • David Diehl
  • Peter Draganov
  • Laith Jamil
  • Ammara Khalid
  • Harshit Khara
  • Vikas Khullar
  • Ryan Law
  • Simon Lo
  • Abraham Mathew
  • Ebrahim Mirakhor
  • Alireza Sedarat
  • Neil Sharma
  • Setareh Sharzehi
  • Anna Tavvakoli
  • Adarsh Thaker
  • Nirav Thosani
  • Dennis Yang
  • Christina Zelt
  • Mihir S Wagh
  • Endoscopy.2020 Jul;doi: 10.1055/a-1219-4516.Epub 2020-07-14.

ラット脳の背側海馬にA2AR-TrkBヘテロ受容体複合体が存在することを証明した。老化に伴うA2ARとTrkBの相互作用の可能性

Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing.
  • Michael Di Palma
  • Stefano Sartini
  • Davide Lattanzi
  • Riccardo Cuppini
  • Mariana Pita-Rodriguez
  • Yoslandy Diaz-Carmenate
  • Manuel Narvaez
  • Kjell Fuxe
  • Dasiel O Borroto-Escuela
  • Patrizia Ambrogini
  • Mech. Ageing Dev..2020 Jun;190:111289. S0047-6374(20)30085-3. doi: 10.1016/j.mad.2020.111289.Epub 2020-06-18.

医師による新しい経口抗糖尿病薬の採用とメディケアおよびメディケイドの薬剤費との関連

Association between physician adoption of a new oral anti-diabetic medication and Medicare and Medicaid drug spending.
  • Ilinca D Metes
  • Lingshu Xue
  • Chung-Chou H Chang
  • Haiden A Huskamp
  • Walid F Gellad
  • Wei-Hsuan Lo-Ciganic
  • Niteesh K Choudhry
  • Seth Richards-Shubik
  • Hasan Guclu
  • Julie M Donohue
  • BMC Health Serv Res.2019 Oct;19(1):703. 10.1186/s12913-019-4520-4. doi: 10.1186/s12913-019-4520-4.Epub 2019-10-16.

蛋白質を用いて、遺伝子組換えとKRAS/RAF-RBDの相互作用を同時にモニタリングするデュアルパラメトリックアッセイの開発を行っています

Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring.
  • Kari Kopra
  • Emmiliisa Vuorinen
  • Maria Abreu-Blanco
  • Qi Wang
  • Ville Eskonen
  • William Gillette
  • Arto T Pulliainen
  • Matthew Holderfield
  • Harri Härmä
  • Anal. Chem..2020 04;92(7):4971-4979. doi: 10.1021/acs.analchem.9b05126.Epub 2020-03-09.

間葉系幹細胞を用いた治療は、血管新生型高血圧を改善し、対側腎臓のナトリウム排泄能力を維持する

Treatment with Mesenchymal Stem Cells Improves Renovascular Hypertension and Preserves the Ability of the Contralateral Kidney to Excrete Sodium.
  • Vanessa Araujo Varela
  • Elizabeth B Oliveira-Sales
  • Edgar Maquigussa
  • Fernanda T Borges
  • Pedro P Gattai
  • Antonio da S Novaes
  • Caroline G Shimoura
  • Ruy R Campos
  • Mirian A Boim
  • Kidney Blood Press. Res..2019;44(6):1404-1415. 000503346. doi: 10.1159/000503346.Epub 2019-10-31.

肥大型閉塞性心筋症に対するアルコール中隔アブレーション後に新たに発症した伝導障害を有するハイリスク患者における電気生理学的研究の役割

The role of electrophysiologic study in high-risk patients with new-onset conduction disturbances following alcohol septal ablation for hypertrophic obstructive cardiomyopathy.
  • Patrick Badertscher
  • Thomas A Turnage
  • Valerian Fernandes
  • Christopher Nielsen
  • Michael R Gold
  • J. Cardiovasc. Electrophysiol..2020 Jul;doi: 10.1111/jce.14670.Epub 2020-07-13.

レニン-アンジオテンシン系遮断薬はラットの神経障害性疼痛の末梢と中枢の両方の成分を調節する。カルシトニン遺伝子関連ペプチド、サブスタンスP、一酸化窒素の役割

Renin-Angiotensin System Blockade modulates both the peripheral and central component of neuropathic pain in rats: Role of Calcitonin gene-related peptide, substance P and nitric oxide.
  • Nora Hegazy
  • Samar Rezq
  • Ahmed Fahmy
  • Basic Clin. Pharmacol. Toxicol..2020 Jun;doi: 10.1111/bcpt.13453.Epub 2020-06-15.

マルチオミクスアプローチにより、肺胞マクロファージにおけるナノ材料の毒性と構造活性の関係を明らかにした

A multi-omics approach reveals mechanisms of nanomaterial toxicity and structure-activity relationships in alveolar macrophages.
  • Anne Bannuscher
  • Isabel Karkossa
  • Sophia Buhs
  • Peter Nollau
  • Katja Kettler
  • Mihaela Balas
  • Anca Dinischiotu
  • Bryan Hellack
  • Martin Wiemann
  • Andreas Luch
  • Martin von Bergen
  • Andrea Haase
  • Kristin Schubert
  • Nanotoxicology.2020 03;14(2):181-195. doi: 10.1080/17435390.2019.1684592.Epub 2019-11-27.

中国人患者のアッシャー症候群の原因遺伝子における複合ヘテロ接合性の新規変異を標的とした次世代シークエンシングにより特定した

Targeted Next-Generation Sequencing Identified Novel Compound Heterozygous Variants in the Gene Causing Usher Syndrome Type ID in a Chinese Patient.
  • Lianmei Zhang
  • Jingliang Cheng
  • Qi Zhou
  • Md Asaduzzaman Khan
  • Jiewen Fu
  • Chengxia Duan
  • Suan Sun
  • Hongbin Lv
  • Junjiang Fu
  • Front Genet.2020;11:422. doi: 10.3389/fgene.2020.00422.Epub 2020-04-30.

オルニチンアミノトランスフェラーゼ遺伝子のc.425-1G>A変異により、高オルニチン血症を伴う脈絡膜および網膜の回旋性萎縮を呈した最初の症例である

First report of c.425-1G>A mutation in ornithine aminotransferase gene causing gyrate atrophy of the choroid and retina with hyperornithinemia.
  • Hossein Jalali
  • Mojtaba Najafi
  • Atefeh Khoshaeen
  • Mohammad Reza Mahdavi
  • Mahan Mahdavi
  • Eur J Ophthalmol.2020 May;:1120672120921734. doi: 10.1177/1120672120921734.Epub 2020-05-17.

コンゴ民主共和国イディオファにおける5歳未満の子どもの下痢の減少に対する衛生設備の改善の効果:クラスター無作為化試験

Effects of improved sanitation on diarrheal reduction for children under five in Idiofa, DR Congo: a cluster randomized trial.
  • Seungman Cha
  • JaeEun Lee
  • DongSik Seo
  • Byoung Mann Park
  • Paul Mansiangi
  • Kabore Bernard
  • Guy Jerome Nkay Mulakub-Yazho
  • Honore Minka Famasulu
  • Infect Dis Poverty.2017 Sep;6(1):137. 10.1186/s40249-017-0351-x. doi: 10.1186/s40249-017-0351-x.Epub 2017-09-19.