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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

多発性硬化症患者におけるヒト免疫不全ウイルス感染症の獲得:これらの状態はお互いの経過にポジティブな影響を与える可能性があるか?

Acquisition of human immunodeficiency virus infection in a patient with multiple sclerosis: could these conditions positively influence each other's course?
  • Ilaria Mainardi
  • Maria Teresa Ferrò
  • Matteo Gastaldi
  • Diego Franciotta
  • Paola Cinque
  • J. Neurovirol..2020 Jul;10.1007/s13365-020-00876-7. doi: 10.1007/s13365-020-00876-7.Epub 2020-07-15.

BMPシグナル伝達経路の阻害は、実験的自己免疫性脳脊髄炎の確立した臨床症状を改善した

Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis.
  • Herena Eixarch
  • Laura Calvo-Barreiro
  • Carme Costa
  • Gemma Reverter-Vives
  • Mireia Castillo
  • Vanessa Gil
  • José Antonio Del Río
  • Xavier Montalban
  • Carmen Espejo
  • Neurotherapeutics.2020 Jul;10.1007/s13311-020-00885-8. doi: 10.1007/s13311-020-00885-8.Epub 2020-07-17.

地下水に生息するエルシマイクロビアは、腸内細菌群のエルシマイクロビアに比べて代謝的に多様であり、一部のエルシマイクロビアは新規なニトロゲナーゼの類縁体を持っている

Groundwater Elusimicrobia are metabolically diverse compared to gut microbiome Elusimicrobia and some have a novel nitrogenase paralog.
  • Raphaël Méheust
  • Cindy J Castelle
  • Paula B Matheus Carnevali
  • Ibrahim F Farag
  • Christine He
  • Lin-Xing Chen
  • Yuki Amano
  • Laura A Hug
  • Jillian F Banfield
  • ISME J.2020 Jul;10.1038/s41396-020-0716-1. doi: 10.1038/s41396-020-0716-1.Epub 2020-07-17.

シングルセルRNA-seqとバルクRNA-seqの統合解析により、腫瘍の不均一性に加えて、TNBCにおけるM2様の腫瘍関連マクロファージ浸潤と攻撃性が解明された

Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and aggressiveness in TNBC.
  • Xuanwen Bao
  • Run Shi
  • Tianyu Zhao
  • Yanfang Wang
  • Natasa Anastasov
  • Michael Rosemann
  • Weijia Fang
  • Cancer Immunol. Immunother..2020 Jul;10.1007/s00262-020-02669-7. doi: 10.1007/s00262-020-02669-7.Epub 2020-07-17.

大腸がんの治療反応予測バイオマーカーとしての遺伝子多型と関連INDEL-個別化医療に向けて

gene polymorphisms and related indel as predictor biomarkers of treatment response for colorectal cancer - toward a personalized medicine.
  • Mouadh Barbirou
  • Ikram Sghaier
  • Sinda Bedoui
  • Rahma Ben Abderrazek
  • Hazar Kraiem
  • Azer Farah
  • Rym Hassiki
  • Amina Mokrani
  • Amel Mezlini
  • Wassim Y Almawi
  • Besma Loueslati-Yacoubi
  • Balkiss Bouhaouala-Zahar
  • Tumour Biol..2020 Jun;42(6):1010428320925237. doi: 10.1177/1010428320925237.

薬剤耐性強迫性障害(OCD)における rTMS 治療の有効性と臨床的予測因子:レトロスペクティブ研究

Efficacy and clinical predictors of response to rTMS treatment in pharmacoresistant obsessive-compulsive disorder (OCD): a retrospective study.
  • Reza Rostami
  • Reza Kazemi
  • Arezoo Jabbari
  • Azam Sadat Madani
  • Hosseinreza Rostami
  • Mohammad Amin Taherpour
  • Parviz Molavi
  • Nematollah Jaafari
  • Min-Fang Kuo
  • Carmelo M Vicario
  • Michael A Nitsche
  • Mohammad Ali Salehinejad
  • BMC Psychiatry.2020 Jul;20(1):372. 10.1186/s12888-020-02769-9. doi: 10.1186/s12888-020-02769-9.Epub 2020-07-16.

特異性タンパク質1のフレームシフト変異が、家族性骨髄不全におけるSp1介在転写のスーパーアクチベーションを誘発することを明らかにした

A frameshift variant in specificity protein 1 triggers superactivation of Sp1-mediated transcription in familial bone marrow failure.
  • Hemanth Tummala
  • Amanda J Walne
  • Findlay Bewicke-Copley
  • Alicia Ellison
  • Nikolas Pontikos
  • Maria G Bridger
  • Ana Rio-Machin
  • Jasmin K Sidhu
  • Jun Wang
  • Henrik Hasle
  • Jude Fitzgibbon
  • Tom Vulliamy
  • Inderjeet Dokal
  • Proc. Natl. Acad. Sci. U.S.A..2020 Jul;202002857. doi: 10.1073/pnas.2002857117.Epub 2020-07-07.

高所得国における社会経済的グループ間の室内空気汚染への曝露。文献のスコープレビューとモデル化の方法論

Exposure to indoor air pollution across socio-economic groups in high-income countries: A scoping review of the literature and a modelling methodology.
  • Lauren Ferguson
  • Jonathon Taylor
  • Michael Davies
  • Clive Shrubsole
  • Phil Symonds
  • Sani Dimitroulopoulou
  • Environ Int.2020 Jul;143:105748. S0160-4120(19)34091-7. doi: 10.1016/j.envint.2020.105748.Epub 2020-07-03.

Brd1発現の低下は、可逆的なうつ病様行動と遺伝子発現の変化をもたらす

Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.
  • Anto P Rajkumar
  • Per Qvist
  • Julie G Donskov
  • Ross Lazarus
  • Jonatan Pallesen
  • Nicoletta Nava
  • Gudrun Winther
  • Nico Liebenberg
  • Sanne H la Cour
  • Veerle Paternoster
  • Tue Fryland
  • Johan Palmfeldt
  • Kim Fejgin
  • Arne Mørk
  • Mette Nyegaard
  • Bente Pakkenberg
  • Michael Didriksen
  • Jens R Nyengaard
  • Gregers Wegener
  • Ole Mors
  • Jane H Christensen
  • Anders D Børglum
  • Transl Psychiatry.2020 Jul;10(1):239. 10.1038/s41398-020-00914-2. doi: 10.1038/s41398-020-00914-2.Epub 2020-07-17.

慢性腎臓病患者におけるクレアチニンとシスタチンCによる糸球体濾過率の不明確な傾向:KNOW-CKDコホートからの結果

Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort.
  • Eunjeong Kang
  • Seung Seok Han
  • Jayoun Kim
  • Sue Kyung Park
  • Wookyung Chung
  • Yun Kyu Oh
  • Dong-Wan Chae
  • Yong-Soo Kim
  • Curie Ahn
  • Kook-Hwan Oh
  • BMC Nephrol.2020 Jul;21(1):280. 10.1186/s12882-020-01932-4. doi: 10.1186/s12882-020-01932-4.Epub 2020-07-16.

COVID-19 パンデミック時の表皮水疱症の集学的ケア-コンセンサス。国際的な専門家パネルによる勧告

Multidisciplinary Care of Epidermolysis Bullosa during the COVID-19 Pandemic - Consensus: Recommendations by an International Panel of Experts.
  • Dedee F Murrell
  • Anne W Lucky
  • Julio C Salas-Alanis
  • David T Woodley
  • Francis Palisson
  • Ken Natsuga
  • Milos Nikolic
  • Mae Ramirez-Quizon
  • Amy S Paller
  • Irene Lara-Corrales
  • Mohammadreza Amir Barzegar
  • Eli Sprecher
  • Cristina Has
  • Martin Laimer
  • Anna L Bruckner
  • Asli Bilgic
  • Arti Nanda
  • Diana Purvis
  • Alain Hovnanian
  • Slobodna Murat-Sušić
  • Johannes Bauer
  • Johannes S Kern
  • Christine Bodemer
  • Linda K Martin
  • Jemima Mellerio
  • Cezary Kowaleski
  • Susan J Robertson
  • Leena Bruckner-Tuderman
  • Elena Pope
  • M Peter Marinkovich
  • Jean Y Tang
  • John Su
  • Jouni Uitto
  • Lawrence F Eichenfield
  • Joyce Teng
  • Mark Jean Aan Koh
  • Sang Eun Lee
  • Phuong Khuu
  • Heather I Rishel
  • Mette Sommerlund
  • Karen Wiss
  • Chao-Kai Hsu
  • Tor Wo Chiu
  • Anna E Martinez
  • J. Am. Acad. Dermatol..2020 Jul;S0190-9622(20)32195-2. doi: 10.1016/j.jaad.2020.06.1023.Epub 2020-07-15.

カタツムリはTOR依存的にエンドサイクリングを同期させ、ショウジョウバエの臨界体重チェックポイントの間にエンドレプリーションの一時停止からの進入と脱出を調整している

Snail synchronizes endocycling in a TOR-dependent manner to coordinate entry and escape from endoreplication pausing during the Drosophila critical weight checkpoint.
  • Jie Zeng
  • Nhan Huynh
  • Brian Phelps
  • Kirst King-Jones
  • PLoS Biol..2020 02;18(2):e3000609. PBIOLOGY-D-19-00191. doi: 10.1371/journal.pbio.3000609.Epub 2020-02-25.

オーストラリアの入院患者の精神保健サービスにおける、攻撃性、自傷行為、性的危害、逃亡などの懸念行動の調査

Exploring behaviours of concern including aggression, self-harm, sexual harm and absconding within an Australian inpatient mental health service.
  • Matthew Kang
  • Hannah Bushell
  • Stuart Lee
  • Caitlin Berry
  • Yitzchak Hollander
  • Ilan Rauchberger
  • Fiona Whitecross
  • Australas Psychiatry.2020 Jun;:1039856220926940. doi: 10.1177/1039856220926940.Epub 2020-06-02.

殺虫性スズメバチ毒素Γ-ポンピリドトキシンは、電位依存性ナトリウムチャネルを調節する線形ペプチドである

The insecticidal wasp toxin Γ-Pompilidotoxin is a linear peptide modulating voltage-gated sodium channels.
  • Steve Peigneur
  • Andrey V Tsarev
  • Alexander S Paramonov
  • Christina I Schroeder
  • Maria P Ikonomopoulou
  • Hidetoshi Inagaki
  • David J Craik
  • Katsuhiro Konno
  • Zakhar O Shenkarev
  • Jan Tytgat
  • Toxicon.2020 Apr;177 Suppl 1:S40. S0041-0101(19)30831-1. doi: 10.1016/j.toxicon.2019.12.069.

カフェイン摂取が確認された早産児を持つ妊婦のコホートにおけるCYP2E1代謝活性の変調

Modulation of CYP2E1 metabolic activity in a cohort of confirmed caffeine ingesting pregnant women with preterm offspring.
  • M R Alcorta-García
  • C N López-Villaseñor
  • G Sánchez-Ferrer
  • H Flores-Mendoza
  • F Castorena-Torres
  • M A Aguilar-Torres
  • C M Sepúlveda-Treviño
  • J A Hernández-Hernández
  • R C López-Sánchez
  • V J Lara-Díaz
  • Mol Cell Pediatr.2020 Jun;7(1):4. 10.1186/s40348-020-00096-3. doi: 10.1186/s40348-020-00096-3.Epub 2020-06-01.

クラドリビンはATF4を介したアポトーシスを誘導し、びまん性大細胞型B細胞リンパ腫細胞においてSAHAと相乗的に作用します

Cladribine Induces ATF4 Mediated Apoptosis and Synergizes with SAHA in Diffuse Large B-Cell Lymphoma Cells.
  • Linyan Xu
  • Jun Jiao
  • Xiaoshen Sun
  • Wei Sang
  • Xiang Gao
  • Pu Yang
  • Dongmei Yan
  • Xuguang Song
  • Cai Sun
  • Mengdi Liu
  • Yuanyuan Qin
  • Yu Tian
  • Feng Zhu
  • Lingyu Zeng
  • Zhenyu Li
  • Kailin Xu
  • Int J Med Sci.2020;17(10):1375-1384. ijmsv17p1375. doi: 10.7150/ijms.41793.Epub 2020-05-30.

限界ヒト腎臓の生体外再生のための冷蔵保存による微小血管閉塞の溶解

Lysis of cold-storage-induced microvascular obstructions for ex vivo revitalization of marginal human kidneys.
  • Jenna R DiRito
  • Sarah A Hosgood
  • Melanie Reschke
  • Claire Albert
  • Laura G Bracaglia
  • John R Ferdinand
  • Benjamin J Stewart
  • Christopher M Edwards
  • Anand G Vaish
  • Sathia Thiru
  • David C Mulligan
  • Danielle J Haakinson
  • Menna R Clatworthy
  • W Mark Saltzman
  • Jordan S Pober
  • Michael L Nicholson
  • Gregory T Tietjen
  • Am. J. Transplant..2020 Jul;doi: 10.1111/ajt.16148.Epub 2020-07-05.

TBX5 R264KはT-box経路とは独立してマウスの拡張型心筋症発症の修飾因子として作用する

TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway.
  • Nariaki Miyao
  • Yukiko Hata
  • Hironori Izumi
  • Ryo Nagaoka
  • Yuko Oku
  • Ichiro Takasaki
  • Taisuke Ishikawa
  • Shinya Takarada
  • Mako Okabe
  • Hideyuki Nakaoka
  • Keijiro Ibuki
  • Sayaka Ozawa
  • Tomoyuki Yoshida
  • Hideyuki Hasegawa
  • Naomasa Makita
  • Naoki Nishida
  • Hisashi Mori
  • Fukiko Ichida
  • Keiichi Hirono
  • PLoS ONE.2020;15(4):e0227393. PONE-D-19-34630. doi: 10.1371/journal.pone.0227393.Epub 2020-04-01.

局所進行性肝胆道悪性腫瘍に対する複雑な肝切除術への肝移植経験の移行性-単施設での 3 10 年間の経験から得られた教訓

Transferability of Liver Transplantation Experience to Complex Liver Resection for Locally Advanced Hepatobiliary Malignancy - Lessons Learnt From 3 Decades of Single Center Experience.
  • Albert C Y Chan
  • Kenneth S H Chok
  • Jeff Dai
  • Simon H Y Tsang
  • Tan To Cheung
  • Ronnie Poon
  • S T Fan
  • C M Lo
  • Ann. Surg..2020 Jul;doi: 10.1097/SLA.0000000000004227.Epub 2020-07-09.

ヤコン(Smallanthus sonchifolius)は、大腸発癌の動物モデルにおいて、炎症、酸化ストレス、腸内変化を抑制しました

Yacón (Smallanthus sonchifolius) prevented inflammation, oxidative stress, and intestinal alterations in an animal model of colorectal carcinogenesis.
  • Thaísa Agrizzi Verediano
  • Mirelle Lomar Viana
  • Maria das Graças Vaz Tostes
  • Daniela Silva de Oliveira
  • Louisiane de Carvalho Nunes
  • Neuza Maria Brunoro Costa
  • J. Sci. Food Agric..2020 Jun;doi: 10.1002/jsfa.10595.Epub 2020-06-21.

カルシウムチャネル遮断剤としてのカルコン誘導体の同定と検討ファーマコフォアモデリング、ドッキング試験、インビトロスクリーニング、3D-QSAR解析

Identification and Investigation of Chalcone Derivatives as Calcium Channel Blockers: Pharmacophore modeling, Docking studies, In-vitro screening, and 3D-QSAR Analysis.
  • Amol S Sherikar
  • Manish S Bhatia
  • Rakesh P Dhavale
  • Curr Comput Aided Drug Des.2020 Jul;CAD-EPUB-108170. doi: 10.2174/1573409916666200714143930.Epub 2020-07-14.

γ9δ2T細胞の多様性と腫瘍細胞との受容体インターフェース

γ9δ2T cell diversity and the receptor interface with tumor cells.
  • Anna Vyborova
  • Dennis X Beringer
  • Domenico Fasci
  • Froso Karaiskaki
  • Eline van Diest
  • Lovro Kramer
  • Aram de Haas
  • Jasper Sanders
  • Anke Janssen
  • Trudy Straetemans
  • Daniel Olive
  • Jeanette Hw Leusen
  • Lola Boutin
  • Steven Nedellec
  • Samantha L Schwartz
  • Michael J Wester
  • Keith A Lidke
  • Emmanuel Scotet
  • Diane Lidke
  • Albert Jr Heck
  • Zsolt Sebestyen
  • Jurgen Kuball
  • J. Clin. Invest..2020 Jun;132489. doi: 10.1172/JCI132489.Epub 2020-06-02.

心不全患者に対するカルベジロール治療におけるβ,β,α-およびα-アドレナリン受容体に対する自己抗体検出の臨床的有用性

Clinical value of detecting autoantibodies against β-, β,- and α-adrenergic receptors in carvedilol treatment of patients with heart failure.
  • Dong-Yan Hou
  • Lin Xu
  • Zhi-Yong Zhang
  • Xiao-Rong Xu
  • Xin Wang
  • Juan Zhang
  • Jia-Mei Liu
  • Hua Wang
  • Jin Chen
  • Lin Zhang
  • J Geriatr Cardiol.2020 Jun;17(6):305-312. jgc-17-06-305. doi: 10.11909/j.issn.1671-5411.2020.06.002.

深海生物ノーザンシュリンプ(Pandalus borealis)と冷水サンゴ(Lophelia pertusa)の石油関連芳香族化合物、分散媒、アラスカノーススロープ原油に対する感受性

The sensitivity of the deepsea species northern shrimp (Pandalus borealis) and the cold-water coral (Lophelia pertusa) to oil-associated aromatic compounds, dispersant, and Alaskan North Slope crude oil.
  • Jenny Bytingsvik
  • Thomas F Parkerton
  • Julien Guyomarch
  • Luca Tassara
  • Stephane LeFloch
  • W Ray Arnold
  • Susanne M Brander
  • Aswani Volety
  • Lionel Camus
  • Mar. Pollut. Bull..2020 Jul;156:111202. S0025-326X(20)30320-9. doi: 10.1016/j.marpolbul.2020.111202.Epub 2020-05-17.

Flk2/Flt3を発現するCD34+CD38-単細胞から増殖させたクローン細胞による非肥満糖尿病/重症複合免疫不全マウスにおけるヒト造血の再構築

Reconstitution of human haematopoiesis in non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34+CD38- cells expressing Flk2/Flt3.
  • Yasuhiro Ebihara
  • Mika Wada
  • Takahiro Ueda
  • Ming-Jiang Xu
  • Atsushi Manabe
  • Ryuhei Tanaka
  • Mamoru Ito
  • Hideo Mugishima
  • Shigetaka Asano
  • Tatsutoshi Nakahata
  • Kohichiro Tsuji
  • Br. J. Haematol..2002 Nov;119(2):525-34. 3820. doi: 10.1046/j.1365-2141.2002.03820.x.

周辺環境への新興有機汚染物質の発生源としての埋立地浸出液のリスク評価と調査:中国済南市最大の埋立地のケーススタディ

Risk assessment and investigation of landfill leachate as a source of emerging organic contaminants to the surrounding environment: a case study of the largest landfill in Jinan City, China.
  • Kun Wang
  • Febelyn Reguyal
  • Tao Zhuang
  • Environ Sci Pollut Res Int.2020 Jul;10.1007/s11356-020-10093-8. doi: 10.1007/s11356-020-10093-8.Epub 2020-07-17.

ALG13 欠損症の 29 例の個体における優勢型および新規 de novo バリアント。臨床的記述、バイオマーカーの状態、生化学的分析と治療の提案

Predominant and novel de novo variants in 29 individuals with ALG13 deficiency: Clinical description, biomarker status, biochemical analysis and treatment suggestions.
  • Bobby G Ng
  • Erik A Eklund
  • Sergey A Shiryaev
  • Yin Y Dong
  • Mary-Alice Abbott
  • Carla Asteggiano
  • Michael J Bamshad
  • Eileen Barr
  • Jonathan A Bernstein
  • Shabeed Chelakkadan
  • John Christodoulou
  • Wendy K Chung
  • Michael A Ciliberto
  • Janice Cousin
  • Fiona Gardiner
  • Suman Ghosh
  • William D Graf
  • Stephanie Grunewald
  • Katherine Hammond
  • Natalie S Hauser
  • George E Hoganson
  • Kimberly M Houck
  • Jennefer N Kohler
  • Eva Morava
  • Austin A Larson
  • Pengfei Liu
  • Sujana Madathil
  • Colleen McCormack
  • Naomi J L Meeks
  • Rebecca Miller
  • Kristin G Monaghan
  • Deborah A Nickerson
  • Timothy Blake Palculict
  • Gabriela Magali Papazoglu
  • Beth A Pletcher
  • Ingrid E Scheffer
  • Andrea Beatriz Schenone
  • Rhonda E Schnur
  • Yue Si
  • Leah J Rowe
  • Alvaro H Serrano Russi
  • Rossana Sanchez Russo
  • Farouq Thabet
  • Allysa Tuite
  • María Mercedes Villanueva
  • Raymond Y Wang
  • Richard I Webster
  • Dorcas Wilson
  • Alice Zalan
  • Undiagnosed Diseases Network
  • Lynne A Wolfe
  • Jill A Rosenfeld
  • Lindsay Rhodes
  • Hudson H Freeze
  • J. Inherit. Metab. Dis..2020 Jul;doi: 10.1002/jimd.12290.Epub 2020-07-18.

1,2-ジメチルヒドラジンに対する肝臓および結腸の亜急性反応に関連する初期の分子イベント。肝臓と大腸の亜急性反応に関連する初期の分子イベント:前腫瘍性病変および新腫瘍性病変の発生に関する潜在的な意味合い

Early molecular events associated with liver and colon sub-acute responses to 1,2-dimethylhydrazine: Potential implications on preneoplastic and neoplastic lesion development.
  • Brunno Felipe Ramos Caetano
  • Mariana Baptista Tablas
  • Guilherme Ribeiro Romualdo
  • Maria Aparecida Marchesan Rodrigues
  • Luís Fernando Barbisan
  • Toxicol. Lett..2020 Sep;329:67-79. S0378-4274(20)30114-4. doi: 10.1016/j.toxlet.2020.04.009.Epub 2020-05-06.

カルバクロールの降圧効果は、ドラッグデリバリーシステムとしてβ-シクロデキストリンに組み込むことで改善される

Antihypertensive effect of carvacrol is improved after incorporation in β-cyclodextrin as a drug delivery system.
  • Liliane Barreto
  • Samuel Barbosa Camargo
  • Raiana Dos Anjos Moraes
  • Carla Fiama Medeiros
  • Anderson de Melo Jesus
  • Afrânio Evangelista
  • Cristiane Flora Villarreal
  • Lucindo José Quintans-Júnior
  • Darízy Flávia Silva
  • Clin. Exp. Pharmacol. Physiol..2020 Jun;doi: 10.1111/1440-1681.13364.Epub 2020-06-22.