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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

非選択的エンドセリン受容体拮抗薬であるボセンタンは、マウスの肺高血圧症を改善する骨髄由来細胞の動態を調節する

A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice.
  • Taichi Kato
  • Yoshihide Mitani
  • Masahiro Masuya
  • Junko Maruyama
  • Hirofumi Sawada
  • Hiroyuki Ohashi
  • Yukiko Ikeyama
  • Shoichiro Otsuki
  • Noriko Yodoya
  • Tsutomu Shinohara
  • Eri Miyata
  • Erquan Zhang
  • Naoyuki Katayama
  • Hideto Shimpo
  • Kazuo Maruyama
  • Yoshihiro Komada
  • Masahiro Hirayama
  • Pulm Circ.2020 Apr-Jun;10(2):2045894020919355. 10.1177_2045894020919355. doi: 10.1177/2045894020919355.Epub 2020-05-14.

大気/液界面(ALI)曝露システムを用いた工業用VOCの触媒酸化除去による排出物のin vitro毒物学的評価

In vitro toxicological evaluation of emissions from catalytic oxidation removal of industrial VOCs by air/liquid interface (ALI) exposure system in repeated mode.
  • Clémence Méausoone
  • Rebecca El Khawaja
  • Gauthier Tremolet
  • Stéphane Siffert
  • Renaud Cousin
  • Fabrice Cazier
  • Sylvain Billet
  • Dominique Courcot
  • Yann Landkocz
  • Toxicol In Vitro.2019 Aug;58:110-117. S0887-2333(18)30782-3. doi: 10.1016/j.tiv.2019.03.030.Epub 2019-03-22.

磁性グラフェン酸化物分散固相抽出法をベースとしたポータブルイオンモビリティースペクトロメトリーによる唾液・尿中の5種類の抗過敏症薬の定量のための迅速かつ簡便なアプローチをご紹介します

A fast and simple approach for the quantification of five anti-hypersensitivity drugs in saliva and urine by portable ion mobility spectrometry based on magnetic graphene oxide dispersive solid phase extraction.
  • Yixuan Cui
  • Di Liu
  • Mengqiang Zhao
  • Junmei Li
  • Yuke Yang
  • Mengjiao Li
  • Jinglin Gao
  • Ye Jiang
  • J Pharm Biomed Anal.2020 Jun;189:113414. S0731-7085(20)31300-5. doi: 10.1016/j.jpba.2020.113414.Epub 2020-06-10.

新規ヘテロ接合性ABCG8変異とSLC4A2多型による肝内胆石症とウルソデオキシコール酸下での良好な成績.

Intrahepatic Cholestasis Owing to a Novel Heterozygous ABCG8 Mutation and SLC4A2 Polymorphism With Favorable Outcome Under Ursodeoxycholic Acid.
  • Dragos Ciocan
  • Cosmin Sebastian Voican
  • Véronique Barbu
  • Christophe Corpechot
  • Dominique Rainteau
  • Sophie Prevot
  • Amandine Lebrun
  • Gabriel Perlemuter
  • Am. J. Gastroenterol..2019 09;114(9):1556-1559. doi: 10.14309/ajg.0000000000000328.

分光技術とケモメトリクスを組み合わせることで、違法と疑われる抗菌薬の迅速な現場での特性評価が可能になります

Spectroscopic techniques combined with chemometrics for fast on-site characterization of suspected illegal antimicrobials.
  • Yaxin Tie
  • Céline Duchateau
  • Shana Van de Steene
  • Corenthin Mees
  • Kris De Braekeleer
  • Thomas De Beer
  • Erwin Adams
  • Eric Deconinck
  • Talanta.2020 Sep;217:121026. S0039-9140(20)30317-9. doi: 10.1016/j.talanta.2020.121026.Epub 2020-04-18.

高い分散能力と生物地理学的断絶が、世界的に分布する岩礁棲息性カルシファイヤーの遺伝的多様性を形成している

High dispersal capacity and biogeographic breaks shape the genetic diversity of a globally distributed reef-dwelling calcifier.
  • Martina Prazeres
  • Raphaël Morard
  • T Edward Roberts
  • Steve S Doo
  • Jamaluddin Jompa
  • Christiane Schmidt
  • Marleen Stuhr
  • Willem Renema
  • Michal Kucera
  • Ecol Evol.2020 Jun;10(12):5976-5989. ECE36335. doi: 10.1002/ece3.6335.Epub 2020-05-14.

動的結腸モデル(DCM)。ポジトロンイメージング技術を用いて特徴づけられたヒト近位大腸のCine-MRIを用いた生体関連インビトロモデル

Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques.
  • Konstantinos Stamatopoulos
  • Sharad Karandikar
  • Mark Goldstein
  • Connor O'Farrell
  • Luca Marciani
  • Sarah Sulaiman
  • Caroline L Hoad
  • Mark J H Simmons
  • Hannah K Batchelor
  • Pharmaceutics.2020 Jul;12(7). E659. doi: 10.3390/pharmaceutics12070659.Epub 2020-07-13.

Ex vivoで拡張された自己脂肪組織由来の間質細胞は、豊胸手術における脂肪移植片の保持力の向上を確実にします。無作為化比較臨床試験

Ex vivo-expanded autologous adipose tissue-derived stromal cells ensure enhanced fat graft retention in breast augmentation: A randomized controlled clinical trial.
  • Stig-Frederik T Kølle
  • Dominik Duscher
  • Mikkel Taudorf
  • Anne Fischer-Nielsen
  • Jesper D Svalgaard
  • Lea Munthe-Fog
  • Bo Jønsson
  • Peter B Selvig
  • Frederik P Mamsen
  • Adam J Katz
  • Stem Cells Transl Med.2020 Jul;doi: 10.1002/sctm.20-0081.Epub 2020-07-08.

ビフィズス菌は、シナプス形成とミクログリア機能を促進することで、生後の発生期に宿主の神経回路を形成している

Bifidobacteria shape host neural circuits during postnatal development by promoting synapse formation and microglial function.
  • Berkley Luck
  • Melinda A Engevik
  • Bhanu Priya Ganesh
  • Elizabeth P Lackey
  • Tao Lin
  • Miriam Balderas
  • Angela Major
  • Jessica Runge
  • Ruth Ann Luna
  • Roy V Sillitoe
  • James Versalovic
  • Sci Rep.2020 May;10(1):7737. 10.1038/s41598-020-64173-3. doi: 10.1038/s41598-020-64173-3.Epub 2020-05-08.

胃癌に対する手術安全性と機能的利益における幽門温存術と遠位胃切除術の比較:システマティックレビューとメタアナリシス

A comparison between pylorus-preserving and distal gastrectomy in surgical safety and functional benefit with gastric cancer: a systematic review and meta-analysis.
  • Xinyu Mao
  • Xinlei Xu
  • Hua Zhu
  • Chunpeng Ji
  • Xu Lu
  • Baolin Wang
  • World J Surg Oncol.2020 Jul;18(1):160. 10.1186/s12957-020-01910-y. doi: 10.1186/s12957-020-01910-y.Epub 2020-07-08.

株DXL由来の食品酵素エンド-1,4-β-キシラナーゼおよびβ-グルカナーゼの安全性評価

Safety evaluation of the food enzyme endo-1,4-β-xylanase and β-glucanase from strain DXL.
  • Vittorio Silano
  • José Manuel Barat Baviera
  • Claudia Bolognesi
  • Pier Sandro Cocconcelli
  • Riccardo Crebelli
  • David Michael Gott
  • Konrad Grob
  • Evgenia Lampi
  • Alicja Mortensen
  • Gilles Rivière
  • Inger-Lise Steffensen
  • Christina Tlustos
  • Henk Van Loveren
  • Laurence Vernis
  • Holger Zorn
  • Boet Glandorf
  • Lieve Herman
  • Francesca Marcon
  • André Penninks
  • Andrew Smith
  • Margarita Aguilera-Gomez
  • Magdalena Andryszkiewicz
  • Davide Arcella
  • Ana Gomes
  • Natália Kovalkovičová
  • Yi Liu
  • Joaquim Maia
  • Claudia Roncancio Peña
  • Andrew Chesson
  • EFSA J.2020 Jan;18(1):e05975. EFS25975. doi: 10.2903/j.efsa.2020.5975.Epub 2020-01-10.

COVID-19パンデミック後の学術放射線科におけるオペレーショナル・ラジオロジー・リカバリー。正常化に向けての動き

Operational Radiology Recovery in Academic Radiology Departments After the COVID-19 Pandemic: Moving Toward Normalcy.
  • Daniel S Siegal
  • Brooke Wessman
  • Jessica Zadorozny
  • Josie Palazzolo
  • Alysia Montana
  • James V Rawson
  • Alexander Norbash
  • Manuel L Brown
  • J Am Coll Radiol.2020 Jul;S1546-1440(20)30748-1. doi: 10.1016/j.jacr.2020.07.004.Epub 2020-07-11.

伝統的なホメオパシー的に製造された金属(Cuprum metallicum)と植物(Gelsemium sempervirens)の医薬品とコントロールの核磁気共鳴特性の検証

Verification of Nuclear Magnetic Resonance Characterization of Traditional Homeopathically Manufactured Metal (Cuprum metallicum) and Plant (Gelsemium sempervirens) Medicines and Controls.
  • Michel Van Wassenhoven
  • Martine Goyens
  • Marc Henry
  • Jean Cumps
  • Philippe Devos
  • Homeopathy.2020 Jul;doi: 10.1055/s-0040-1710022.Epub 2020-07-02.

自己拡張型EvololutR弁を用いたTAVRにおける患者特定コンピュータシミュレーション

Patient-Specific Computer Simulation in TAVR With the Self-Expanding Evolut R Valve.
  • Nahid El Faquir
  • Ole De Backer
  • Johan Bosmans
  • Tanja Rudolph
  • Nicola Buzzatti
  • Gintautas Bieliauskas
  • Valerie Collas
  • Hendrik Wienemann
  • Davide Schiavi
  • Paul Cummins
  • Zouhair Rahhab
  • Herbert Kroon
  • Quinten Wolff
  • Mattie Lenzen
  • Joana Maria Ribeiro
  • Azeem Latib
  • Matti Adam
  • Lars Søndergaard
  • Ben Ren
  • Nicolas Van Mieghem
  • Peter de Jaegere
  • JACC Cardiovasc Interv.2020 Jul;S1936-8798(20)30959-6. doi: 10.1016/j.jcin.2020.04.018.Epub 2020-07-08.

ヒトのBDNF/TrkB変異体は海馬のシナプス形成を阻害し、神経行動異常と関連している

Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities.
  • Takuhiro Sonoyama
  • Lukas K J Stadler
  • Mingyan Zhu
  • Julia M Keogh
  • Elana Henning
  • Fuki Hisama
  • Peter Kirwan
  • Magdalena Jura
  • Beata K Blaszczyk
  • David C DeWitt
  • Bas Brouwers
  • Marko Hyvönen
  • Inês Barroso
  • Florian T Merkle
  • Suzanne M Appleyard
  • Gary A Wayman
  • I Sadaf Farooqi
  • Sci Rep.2020 Jun;10(1):9028. 10.1038/s41598-020-65531-x. doi: 10.1038/s41598-020-65531-x.Epub 2020-06-03.

常に再生可能な接触殺傷抗菌表面と抗バイオフィルムおよび無抽出特性を有するバイオミメティックな生分解性Ag@Auナノ粒子包埋尿管ステント

Biomimetic biodegradable Ag@Au nanoparticle-embedded ureteral stent with a constantly renewable contact-killing antimicrobial surface and antibiofilm and extraction-free properties.
  • Liheng Gao
  • Yiwei Wang
  • Yimeng Li
  • Mingxi Xu
  • Gang Sun
  • Ting Zou
  • Fujun Wang
  • Sijun Xu
  • Jun Da
  • Lu Wang
  • Acta Biomater.2020 Jul;S1742-7061(20)30411-6. doi: 10.1016/j.actbio.2020.07.025.Epub 2020-07-16.

コートジボワールにおける2007年から2016年までの急性弛緩性麻痺のサーベイランス。非ポリウイルス性エンテロウイルスの意義と疫学的プロファイル

[Surveillance of acute flaccid paralysis in Ivory Coast between 2007 and 2016: Significance and epidemiological profile of non-poliovirus enteroviruses].
  • Lepri Bernadin Nicaise Aka
  • Kouadio Daniel Ekra
  • Gnissan Henri Auguste Yao
  • Alfred Douba
  • Bangaman Christian Akani
  • Zakaria Keita
  • Serge Aimé Dali
  • Kassoum Kayentao
  • Hamadoun Sangho
  • Doumbia Seydou
  • Sante Publique.2019 November December;31(6):837-843. doi: 10.3917/spub.196.0837.

A Clinicopathological Approach to Odontogenic Cysts: the Role of Cytokeratin 17 and bcl2 Immunohistochemistry in Identifying Odontogenic Keratocysts

A Clinicopathological Approach to Odontogenic Cysts: the Role of Cytokeratin 17 and bcl2 Immunohistochemistry in Identifying Odontogenic Keratocysts.
  • Dorottya Cserni
  • Tamás Zombori
  • András Vörös
  • Anette Stájer
  • Annamária Rimovszki
  • Krisztián Daru
  • Zoltán Baráth
  • Gábor Cserni
  • Pathol. Oncol. Res..2020 Jul;10.1007/s12253-020-00866-4. doi: 10.1007/s12253-020-00866-4.Epub 2020-07-06.

ショウジョウバエの進化の過程における遺伝子座のヘテロクロマチンへの適応は、インシュレータータンパク質と関連している

Adaptation of gene loci to heterochromatin in the course of Drosophila evolution is associated with insulator proteins.
  • Sergei Yu Funikov
  • Alexander P Rezvykh
  • Dina A Kulikova
  • Elena S Zelentsova
  • Lyudmila A Protsenko
  • Lyubov N Chuvakova
  • Venera I Tyukmaeva
  • Irina R Arkhipova
  • Michael B Evgen'ev
  • Sci Rep.2020 Jul;10(1):11893. 10.1038/s41598-020-68879-2. doi: 10.1038/s41598-020-68879-2.Epub 2020-07-17.

横隔膜NMJの神経筋接合部の神経支配はsGC/cGMPシグナルによって制御されているか?

Is Innervation of the Neuromuscular Junction at the Diaphragm Modulated by sGC/cGMP Signaling?
  • Nadežda Lukáčová
  • L'udmila Hricová
  • Alexandra Kisucká
  • Štefánia Papcunová
  • Katarína Bimbová
  • Mária Bačová
  • Jaroslav Pavel
  • Martin Marsala
  • Ivo Vanický
  • Zuzana Dzurjašková
  • Stanislav Matéffy
  • Viktória Lukáčová
  • Andrea Stropkovská
  • Ján Gálik
  • Front Physiol.2020;11:700. doi: 10.3389/fphys.2020.00700.Epub 2020-06-23.

識別とメラノーマ関連網膜症患者の血清からの新規 TRPM1 自己抗体の特徴付け

Identification and characterization of novel TRPM1 autoantibodies from serum of patients with melanoma-associated retinopathy.
  • Juliette Varin
  • Margaret M Reynolds
  • Nassima Bouzidi
  • Sarah Tick
  • Juliette Wohlschlegel
  • Ondine Becquart
  • Christelle Michiels
  • Olivier Dereure
  • Robert M Duvoisin
  • Catherine W Morgans
  • José-Alain Sahel
  • Quentin Samaran
  • Bernard Guillot
  • José S Pulido
  • Isabelle Audo
  • Christina Zeitz
  • PLoS ONE.2020;15(4):e0231750. PONE-D-19-30946. doi: 10.1371/journal.pone.0231750.Epub 2020-04-23.

核磁気共鳴イメージングによる癌の生体分布の可視化のためのペプチド・トランスポーター標的化Fdipeptidesの有用性の可能性

Possible utility of peptide-transporter-targeting [F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging.
  • Hiroshi Arakawa
  • Hiroyuki Yamada
  • Kazutaka Arai
  • Takumi Kawanishi
  • Nobuhiro Nitta
  • Sayaka Shibata
  • Eiko Matsumoto
  • Kentaro Yano
  • Yukio Kato
  • Takuya Kumamoto
  • Ichio Aoki
  • Takuo Ogihara
  • Int J Pharm.2020 Jul;586:119575. S0378-5173(20)30559-7. doi: 10.1016/j.ijpharm.2020.119575.Epub 2020-07-02.

スポーツ傷害研究における方法に関する声明 第1回METHODS MATTER会議、コペンハーゲン、2019年より

Statement on Methods in Sport Injury Research From the First METHODS MATTER Meeting, Copenhagen, 2019.
  • Rasmus Østergaard Nielsen
  • Ian Shrier
  • Martí Casals
  • Alberto Nettel-Aguirre
  • Merete Møller
  • Caroline Bolling
  • Nataliá F N Bittencourt
  • Ben Clarsen
  • Niels Wedderkopp
  • Torbjørn Soligard
  • Toomas Timpka
  • Carolyn A Emery
  • Roald Bahr
  • Jenny Jacobsson
  • Rod Whiteley
  • Örjan Dahlström
  • Nicol van Dyk
  • Babette M Pluim
  • Emmanuel Stamatakis
  • Luz Palacios-Derflingher
  • Morten W Fagerland
  • Karim M Khan
  • Clare L Ardern
  • Evert Verhagen
  • J Orthop Sports Phys Ther.2020 May;50(5):226-233. doi: 10.2519/jospt.2020.9876.

WRKY55転写因子は、シロイヌナズナの活性酸素とサリチル酸の生合成に関与する遺伝子の転写を調節することで、葉の老化と防御応答を正に制御している

WRKY55 transcription factor positively regulates leaf senescence and defense response through modulating the transcription of genes implicated in ROS and SA biosynthesis in Arabidopsis.
  • Yiqiao Wang
  • Xing Cui
  • Bo Yang
  • Shutao Xu
  • Xiangyan Wei
  • Peiyu Zhao
  • Fangfang Niu
  • Mengting Sun
  • Chen Wang
  • Hao Cheng
  • Yuan-Qing Jiang
  • Development.2020 Jul;dev.189647. doi: 10.1242/dev.189647.Epub 2020-07-17.

メトホルミン塩酸塩の徐放性を制御して線維化を緩和し、創傷治癒を促進するための二重機能を持つ3層構造の足場の設計、作製、最適化

Design, fabrication, and optimization of a dual function three-layer scaffold for controlled release of metformin hydrochloride to alleviate fibrosis and accelerate wound healing.
  • Faraz Chogan
  • Tahereh Mirmajidi
  • Ali Hossein Rezayan
  • Ali Mohammad Sharifi
  • Aziz Ghahary
  • Jhamak Nourmohammadi
  • Amir Kamali
  • Mahdi Rahaie
  • Acta Biomater.2020 Jun;S1742-7061(20)30361-5. doi: 10.1016/j.actbio.2020.06.031.Epub 2020-06-23.

nCOVID-19の免疫病態と、効果的な治療と死亡者数の減少のための抗炎症・抗ウイルスプロスタグランジン(PG J)を含む宿主指示療法の可能性

Immuno-pathogenesis of nCOVID-19 and a possible host-directed therapy including anti-inflammatory and anti-viral prostaglandin (PG J) for effective treatment and reduction in the death toll.
  • Shakeel Shahzad
  • Mark Willcox
  • Med. Hypotheses.2020 Jul;143:110080. S0306-9877(20)31926-5. doi: 10.1016/j.mehy.2020.110080.Epub 2020-07-08.

麹菌のクロロフィル生合成と初期葉緑体発生を制御する黄色蛍光遺伝子の特性評価とファインマップの作成

Characterization and Fine Mapping of a Yellow-Virescent Gene Regulating Chlorophyll Biosynthesis and Early Stage Chloroplast Development in .
  • Chuanji Zhao
  • Lijiang Liu
  • Luqman Bin Safdar
  • Meili Xie
  • Xiaohui Cheng
  • Yueying Liu
  • Yang Xiang
  • Chaobo Tong
  • Jinxing Tu
  • Junyan Huang
  • Shengyi Liu
  • G3 (Bethesda).2020 Jul;g3.401460.2020. doi: 10.1534/g3.120.401460.Epub 2020-07-09.

軟骨石灰化は、膝関節の組織学的変性と関連している:非常に普及している、年齢に依存しない全身性のプロセス

Cartilage calcification is associated with histological degeneration of the knee joint: a highly prevalent, age-independent systemic process.
  • Jan Hubert
  • Frank Timo Beil
  • Tim Rolvien
  • Sebastian Butscheidt
  • Sandra Hischke
  • Klaus Püschel
  • Stephan Frosch
  • Haider Mussawy
  • Christian Ries
  • Thelonius Hawellek
  • Osteoarthr. Cartil..2020 Jul;S1063-4584(20)31063-3. doi: 10.1016/j.joca.2020.04.020.Epub 2020-07-16.

市販のホエイ製品は、細菌性エンドトキシン・リポ多糖類(LPS)誘発炎症をin vitroで抑制するグリコマクロペプチド強化活性を有し、腸管バリア機能を促進する

Commercial whey products promote intestinal barrier function with glycomacropeptide enhanced activity in downregulating bacterial endotoxin lipopolysaccharides (LPS)-induced inflammation in vitro.
  • Shirley Arbizu
  • Boon Chew
  • Susanne U Mertens-Talcott
  • Giuliana Noratto
  • Food Funct.2020 Jul;doi: 10.1039/d0fo00487a.Epub 2020-07-07.

ジペプチジルペプチダーゼ-4阻害薬シタグリプチンは、KvチャネルとPKAの活性化を介して血管弛緩を誘導する

Dipeptidyl peptidase-4 inhibitor sitagliptin induces vasorelaxation via the activation of Kv channels and PKA.
  • Hongliang Li
  • Mi Seon Seo
  • Jin Ryeol An
  • Hee Seok Jung
  • Kwon-Soo Ha
  • Eun-Taek Han
  • Seok-Ho Hong
  • Young Min Bae
  • Sung Hun Na
  • Won Sun Park
  • Toxicol. Appl. Pharmacol..2019 12;384:114799. S0041-008X(19)30407-7. doi: 10.1016/j.taap.2019.114799.Epub 2019-10-31.

ペメトレキセド化学療法が患者肺由来腫瘍異種移植(PDX)マウスモデルの腸内マイクロバイオータおよび腸内炎症に及ぼす影響

Impact of pemetrexed chemotherapy on the gut microbiota and intestinal inflammation of patient-lung-derived tumor xenograft (PDX) mouse models.
  • Cindy Pensec
  • Florence Gillaizeau
  • Dominique Guenot
  • Anne Bessard
  • Thomas Carton
  • Sébastien Leuillet
  • Mario Campone
  • Michel Neunlist
  • Hervé M Blottière
  • Françoise Le Vacon
  • Sci Rep.2020 Jun;10(1):9094. 10.1038/s41598-020-65792-6. doi: 10.1038/s41598-020-65792-6.Epub 2020-06-04.

新規抗がん剤として期待されるフェニルクロルメチン-キナゾリン誘導体の合成、Sirt1/caspase3シグナル伝達経路を介して肝細胞がんのアポトーシスを誘導した

Synthesis of a New Phenyl Chlormethine-Quinazoline Derivative, a Potential Anti-Cancer Agent, Induced Apoptosis in Hepatocellular Carcinoma Through Mediating Sirt1/Caspase 3 Signaling Pathway.
  • Jia-Jia Lv
  • Wen-Ting Song
  • Xin-Min Li
  • Jian-Mei Gao
  • Ze-Li Yuan
  • Front Pharmacol.2020;11:911. doi: 10.3389/fphar.2020.00911.Epub 2020-06-26.

低リスクの小児急性骨髄性白血病における良好な転帰を維持しつつ、アントラサイクリンの累積曝露を減らす戦略

A strategy to reduce cumulative anthracycline exposure in low-risk pediatric acute myeloid leukemia while maintaining favorable outcomes.
  • Himalee S Sabnis
  • Katherine A Minson
  • Caitlin Monroe
  • Kristen Allen
  • Jonathan L Metts
  • Todd M Cooper
  • William G Woods
  • Sharon M Castellino
  • Frank G Keller
  • Leuk. Res..2020 Jul;96:106421. S0145-2126(20)30126-0. doi: 10.1016/j.leukres.2020.106421.Epub 2020-07-12.

タンパク質ネットワーク解析により、AECOPD患者の血小板脱顆粒、タンパク質分解、コレステロール代謝経路に関与するタンパク質のレベルの変化が明らかになった

Protein Network Analysis Identifies Changes in the Level of Proteins Involved in Platelet Degranulation, Proteolysis and Cholesterol Metabolism Pathways in AECOPD Patients.
  • Dino B A Tan
  • Jason Ito
  • Kirsten Peters
  • Andreja Livk
  • Richard J Lipscombe
  • Tammy M Casey
  • Yuben P Moodley
  • COPD.2020 Feb;17(1):29-33. doi: 10.1080/15412555.2019.1711035.Epub 2020-01-10.

また、トリソミー21脳内オルガノイドの患者特異的アルツハイマー様病態を明らかにし、BACE2がヒト脳内のADサプレッサー遺伝子であることを明らかにした

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
  • Ivan Alić
  • Pollyanna A Goh
  • Aoife Murray
  • Erik Portelius
  • Eleni Gkanatsiou
  • Gillian Gough
  • Kin Y Mok
  • David Koschut
  • Reinhard Brunmeir
  • Yee Jie Yeap
  • Niamh L O'Brien
  • Jürgen Groet
  • Xiaowei Shao
  • Steven Havlicek
  • N Ray Dunn
  • Hlin Kvartsberg
  • Gunnar Brinkmalm
  • Rosalyn Hithersay
  • Carla Startin
  • Sarah Hamburg
  • Margaret Phillips
  • Konstantin Pervushin
  • Mark Turmaine
  • David Wallon
  • Anne Rovelet-Lecrux
  • Hilkka Soininen
  • Emanuela Volpi
  • Joanne E Martin
  • Jia Nee Foo
  • David L Becker
  • Agueda Rostagno
  • Jorge Ghiso
  • Željka Krsnik
  • Goran Šimić
  • Ivica Kostović
  • Dinko Mitrečić
  • Paul T Francis
  • Kaj Blennow
  • Andre Strydom
  • John Hardy
  • Henrik Zetterberg
  • Dean Nižetić
  • Mol. Psychiatry.2020 Jul;10.1038/s41380-020-0806-5. doi: 10.1038/s41380-020-0806-5.Epub 2020-07-10.

再生不良性貧血に対するアンドロゲンステロイドの長期投与に伴う多発性肝細胞腺腫。症例報告と文献レビュー

Multiple hepatocellular adenomas associated with long-term administration of androgenic steroids for aplastic anemia: A case report and literature review.
  • Lixia Wang
  • Cong Wang
  • Wei Li
  • Fanyang Meng
  • Yuying Li
  • Hongqiong Fan
  • Yanhua Zhou
  • Gnana Bharathi
  • Sujun Gao
  • Yan Yang
  • Medicine (Baltimore).2020 Jul;99(28):e20829. 00005792-202007100-00027. doi: 10.1097/MD.0000000000020829.

単一カラムクロマトグラフィー分離とSF-ICP-MS分析を組み合わせた中分解能モードでの河川水中のラジウム226の簡易かつ高感度測定

Simple and sensitive determination of radium-226 in river water by single column-chromatographic separation coupled to SF-ICP-MS analysis in medium resolution mode.
  • Guosheng Yang
  • Jian Zheng
  • Keiko Tagami
  • Shigeo Uchida
  • Jing Zhang
  • Jinlong Wang
  • Jinzhou Du
  • J Environ Radioact.2020 Sep;220-221:106305. S0265-931X(20)30178-8. doi: 10.1016/j.jenvrad.2020.106305.Epub 2020-05-25.

特定の有機炭素源を用いた石油生産に伴うTENORMスケール廃棄物中のラジウム同位体溶解の速度論とメカニズム:乳酸溶液を用いたケーススタディ

Kinetics and mechanism of radium-isotopes dissolution in TENORM scale waste associated with petroleum production using certain organic carbon source: lactic acid solution-case study.
  • Elsayed M El Afifi
  • Ahmed M Shahr El-Din
  • Moustafa A Hilal
  • Environ Sci Pollut Res Int.2020 Jul;10.1007/s11356-020-09863-1. doi: 10.1007/s11356-020-09863-1.Epub 2020-07-03.

また、重症硫黄マスタード眼損傷者の涙および血清MMP-9および血清TIMPsレベルを評価した

Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients.
  • Hassan Ghasemi
  • Roya Yaraee
  • Soghrat Faghihzadeh
  • Mohammad Ghassemi-Broumand
  • Mahmoud Mahmoudi
  • Mahmoud Babaei
  • Mostafa Naderi
  • Maliheh Safavi
  • Zeinab Ghazanfari
  • Maryam Rastin
  • Shahrzad Zamani
  • Nafiseh Tabasi
  • Elham Faghihzadeh
  • Reza Gharebaghi
  • Zuhair Mohammad Hassan
  • Ensie Sadat Mirsharif
  • Tooba Ghazanfari
  • Int. Immunopharmacol..2019 Dec;77:105812. S1567-5769(19)31188-9. doi: 10.1016/j.intimp.2019.105812.Epub 2019-10-31.

葉緑体のカリウム流出防止因子は、それぞれ光合成に影響を与え、短日光環境下での完全に発達したシロイヌナズナのロゼットの成長にも影響を与えている

Each of the chloroplast potassium efflux antiporters affects photosynthesis and growth of fully developed Arabidopsis rosettes under short-day photoperiod.
  • Somnath Dana
  • Andrei Herdean
  • Björn Lundin
  • Cornelia Spetea
  • Physiol Plant.2016 Dec;158(4):483-491. doi: 10.1111/ppl.12452.Epub 2016-06-09.

Erv14カーゴ受容体は酵母の耐塩性に関与しており、その相互作用は膜上のNha1カチオン/プロトンアンチポーターとの相互作用を介しています

Erv14 cargo receptor participates in yeast salt tolerance via its interaction with the plasma-membrane Nha1 cation/proton antiporter.
  • Paul Rosas-Santiago
  • Olga Zimmermannova
  • Rosario Vera-Estrella
  • Hana Sychrová
  • Omar Pantoja
  • Biochim. Biophys. Acta.2016 Jan;1858(1):67-74. S0005-2736(15)00328-4. doi: 10.1016/j.bbamem.2015.09.024.Epub 2015-10-09.

TheraP:進行性転移性去勢抵抗性前立腺がんを対象としたLu-PSMA-617セラノシス治療 vs カバジタキセルの無作為化第2相試験(Clinical Trial Protocol ANZUP 1603)

TheraP: a randomized phase 2 trial of Lu-PSMA-617 theranostic treatment vs cabazitaxel in progressive metastatic castration-resistant prostate cancer (Clinical Trial Protocol ANZUP 1603).
  • Michael S Hofman
  • Louise Emmett
  • John Violet
  • Alison Y Zhang
  • Nicola J Lawrence
  • Martin Stockler
  • Roslyn J Francis
  • Amir Iravani
  • Scott Williams
  • Arun Azad
  • Andrew Martin
  • Margaret McJannett
  • Ian D Davis
  • BJU Int..2019 11;124 Suppl 1:5-13. doi: 10.1111/bju.14876.Epub 2019-10-22.

mTORの阻害は、実験的な虚脱性局所セグメント糸球体硬化症を遅らせるが、予防することはできなかった

Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis.
  • Laura Miesen
  • Jennifer Eymael
  • Shagun Sharma
  • Markus A Loeven
  • Brigith Willemsen
  • Marinka Bakker-van Bebber
  • Fieke Mooren
  • Catherine Meyer-Schwesinger
  • Henry Dijkman
  • Jack F M Wetzels
  • Jitske Jansen
  • Johan van der Vlag
  • Bart Smeets
  • Sci Rep.2020 May;10(1):8580. 10.1038/s41598-020-65352-y. doi: 10.1038/s41598-020-65352-y.Epub 2020-05-22.

植物由来の生物活性物質の抗がん作用の可能性についての洞察。前立腺癌に焦点を当てる

Insights on the anticancer potential of plant-food bioactives: A key focus to prostate cancer.
  • Bahare Salehi
  • Patrick Valere Tsouh Fokou
  • Lauve Rachel Tchokouaha Yamthe
  • Brice Tchatat Tali
  • Charles Oluwaseun Adetunji
  • Amirhossein Rahavian
  • Fhatuwani Nixwell Mudau
  • Natália Martins
  • Miquel Martorell
  • Célia F Rodrigues
  • William N Setzer
  • Mehdi Sharifi-Rad
  • Ryszard Amarowicz
  • Javad Sharifi-Rad
  • Cell. Mol. Biol. (Noisy-le-grand).2020 Jun;66(4):250-263. Epub 2020-06-25.

非虚血性心筋症における心室頻拍アブレーション後の長期成績。晩期の電位廃止とVT非誘導性

Long-Term Outcome after Ventricular Tachycardia Ablation in Non-Ischemic Cardiomyopathy: Late Potential Abolition and VT Noninducibility.
  • Kenji Okubo
  • Lorenzo Gigli
  • Nicola Trevisi
  • Luca Foppoli
  • Andrea Radinovic
  • Caterina Bisceglia
  • Antonio Frontera
  • Giuseppe D'Angelo
  • Manuela Cireddu
  • Gabriele Paglino
  • Patrizio Mazzone
  • Paolo Della Bella
  • Circ Arrhythm Electrophysiol.2020 Jul;doi: 10.1161/CIRCEP.119.008307.Epub 2020-07-12.

Circular RNA 406961はILF2と相互作用し、STAT3/JNK経路の活性化を介してヒト気管支上皮細胞におけるPM誘導性炎症反応を調節する

Circular RNA 406961 interacts with ILF2 to regulate PM-induced inflammatory responses in human bronchial epithelial cells via activation of STAT3/JNK pathways.
  • Yangyang Jia
  • Xin Li
  • Aruo Nan
  • Nan Zhang
  • Lijian Chen
  • Hanyu Zhou
  • Han Zhang
  • Miaoyun Qiu
  • Jialu Zhu
  • Yihui Ling
  • Yiguo Jiang
  • Environ Int.2020 Aug;141:105755. S0160-4120(19)33945-5. doi: 10.1016/j.envint.2020.105755.Epub 2020-05-07.

研究のための角膜提供と移植のための角膜提供。フランスの大学病院における受け入れ率の1年間のプロスペクティブ研究

Corneal donation for research versus for transplantation: A-year prospective study of acceptance rates in a French University Hospital.
  • Thibaud Garcin
  • Jean Loup Pugniet
  • Thierry Peyragrosse
  • Francoise Rogues
  • Sophie Acquart
  • Fabrice Cognasse
  • Gilles Thuret
  • Philippe Gain
  • PLoS ONE.2020;15(5):e0233392. PONE-D-19-35417. doi: 10.1371/journal.pone.0233392.Epub 2020-05-21.

1 型糖尿病の青年および若年成人における血糖コントロールに対する持続的血糖モニタリングの効果。無作為化臨床試験

Effect of Continuous Glucose Monitoring on Glycemic Control in Adolescents and Young Adults With Type 1 Diabetes: A Randomized Clinical Trial.
  • Lori M Laffel
  • Lauren G Kanapka
  • Roy W Beck
  • Katherine Bergamo
  • Mark A Clements
  • Amy Criego
  • Daniel J DeSalvo
  • Robin Goland
  • Korey Hood
  • David Liljenquist
  • Laurel H Messer
  • Roshanak Monzavi
  • Thomas J Mouse
  • Priya Prahalad
  • Jennifer Sherr
  • Jill H Simmons
  • R Paul Wadwa
  • Ruth S Weinstock
  • Steven M Willi
  • Kellee M Miller
  • JAMA.2020 06;323(23):2388-2396. 2767160. doi: 10.1001/jama.2020.6940.

デュシェンヌ型筋ジストロフィーを持つ小児におけるrAAVrh74.MHCK7.マイクロジストロフィンの全身投与の評価。非ランダム化対照試験

Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial.
  • Jerry R Mendell
  • Zarife Sahenk
  • Kelly Lehman
  • Carrie Nease
  • Linda P Lowes
  • Natalie F Miller
  • Megan A Iammarino
  • Lindsay N Alfano
  • Amanda Nicholl
  • Samiah Al-Zaidy
  • Sarah Lewis
  • Kathleen Church
  • Richard Shell
  • Linda H Cripe
  • Rachael A Potter
  • Danielle A Griffin
  • Eric Pozsgai
  • Ashish Dugar
  • Mark Hogan
  • Louise R Rodino-Klapac
  • JAMA Neurol.2020 Jun;2767086. doi: 10.1001/jamaneurol.2020.1484.Epub 2020-06-15.

ナイアシンアミドの最適化された低pH製剤は、ヒト表皮ケラチノサイトにおけるオートファジーマーカーATG5遺伝子の発現とタンパク質レベルの誘導を増強する

Optimized low pH formulation of niacinamide enhances induction of autophagy marker ATG5 gene expression and protein levels in human epidermal keratinocytes.
  • J E Oblong
  • Y M DeAngelis
  • B B Jarrold
  • J C Bierman
  • H A Rovito
  • L Vires
  • B Fang
  • T Laughlin
  • W Zhao
  • S M Hartman
  • R Kainkaryam
  • R Adams
  • J D Sherrill
  • T Hakozaki
  • J Eur Acad Dermatol Venereol.2020 Jun;34 Suppl 3:3-11. doi: 10.1111/jdv.16582.

12N-置換マトリノール誘導体は肝細胞のステラート細胞におけるインテグリン/FAK/PI3K/Akt経路の抑制を介して線維性遺伝子の発現を抑制した

12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells.
  • Yunyang Bao
  • Yudong Pang
  • Sheng Tang
  • Tianyun Niu
  • Zhihao Guo
  • Hongwei He
  • Yinghong Li
  • Danqing Song
  • Molecules.2019 Oct;24(20). E3748. doi: 10.3390/molecules24203748.Epub 2019-10-17.

NOX2とミトコンドリア由来の活性酸素によるカタラーゼS-グルタチオン化はマウスとヒト好中球の生存に悪影響を及ぼす

Catalase S-Glutathionylation by NOX2 and Mitochondrial-Derived ROS Adversely Affects Mice and Human Neutrophil Survival.
  • Sheela Nagarkoti
  • Megha Dubey
  • Samreen Sadaf
  • Deepika Awasthi
  • Tulika Chandra
  • Kumaravelu Jagavelu
  • Sachin Kumar
  • Madhu Dikshit
  • Inflammation.2019 Dec;42(6):2286-2296. 10.1007/s10753-019-01093-z. doi: 10.1007/s10753-019-01093-z.

COVID-19に対するインターフェロンβ-1aの皮下投与。非対照プロスペクティブ試験

Subcutaneous administration of interferon beta-1a for COVID-19: A non-controlled prospective trial.
  • Farzaneh Dastan
  • Seyed Alireza Nadji
  • Ali Saffaei
  • Majid Marjani
  • Afshin Moniri
  • Hamidreza Jamaati
  • Seyed MohammadReza Hashemian
  • Parvaneh Baghaei
  • Atefeh Abedini
  • Mohammad Varahram
  • Sahar Yousefian
  • Payam Tabarsi
  • Int. Immunopharmacol..2020 Aug;85:106688. S1567-5769(20)31289-3. doi: 10.1016/j.intimp.2020.106688.Epub 2020-06-07.

PROLAPSE:外部ビーム再照射による局所前立腺癌再発サルベージ治療に関する調査:イタリア放射線治療・臨床腫瘍学会(AIRO)の結果

PROLAPSE: survey about local prostate cancer relapse salvage treatment with external beam re-irradiation: results of the Italian Association of Radiotherapy and Clinical Oncology (AIRO).
  • Dario Zerini
  • Barbara Alicja Jereczek-Fossa
  • Antonella Ciabattoni
  • Alessandra Mirri
  • Filippo Bertoni
  • Sergio Fersino
  • Giuseppe D'Agostino
  • Frank Lohr
  • Gianluca Mortellaro
  • Luca Triggiani
  • Giulia Marvaso
  • Matteo Pepa
  • Francesco Cuccia
  • Filippo Alongi
  • J. Cancer Res. Clin. Oncol..2020 Jun;10.1007/s00432-020-03297-5. doi: 10.1007/s00432-020-03297-5.Epub 2020-06-24.

根治的前立腺切除術前の局所転移を除外するためのGa標識前立腺特異膜抗原PET/CTとマルチパラメトリックMRIの比較

A comparison between Ga-labeled prostate-specific membrane antigen-PET/CT and multiparametric MRI for excluding regional metastases prior to radical prostatectomy.
  • Michael Frumer
  • Nadav Milk
  • Gal Rinott Mizrahi
  • Sergiu Bistritzky
  • Itay Sternberg
  • Ilan Leibovitch
  • Yoram Dekel
  • Gilad E Amiel
  • Amnon Zisman
  • Jack Baniel
  • Miki Haifler
  • Jonathan Gal
  • Azik Hoffman
  • Itay Sagy
  • Barak Rosenzweig
  • Rennen Haramaty
  • Shay Golan
  • Abdom Radiol (NY).2020 Jul;10.1007/s00261-020-02640-1. doi: 10.1007/s00261-020-02640-1.Epub 2020-07-15.

AKAP-PKA 相互作用の破壊は、ヒト気道平滑筋における増殖マーカーの付随的な増加と高収縮性を誘導する

Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle.
  • Hoeke A Baarsma
  • Bing Han
  • Wilfred J Poppinga
  • Saskia Driessen
  • Carolina R S Elzinga
  • Andrew J Halayko
  • Herman Meurs
  • Harm Maarsingh
  • Martina Schmidt
  • Front Cell Dev Biol.2020;8:165. doi: 10.3389/fcell.2020.00165.Epub 2020-04-09.

慢性心不全は、イヌの中庭細胞におけるアデノシンの負のクロノトロピー作用を、A1R刺激とGIRK介在Iを介して増加させる

Chronic heart failure increases negative chronotropic effects of adenosine in canine sinoatrial cells via A1R stimulation and GIRK-mediated I.
  • Victor P Long
  • Ingrid M Bonilla
  • Stephen Baine
  • Patric Glynn
  • Sanjay Kumar
  • Karsten Schober
  • Kent Mowrey
  • Raul Weiss
  • Nam Y Lee
  • Peter J Mohler
  • Sandor Györke
  • Thomas J Hund
  • Vadim V Fedorov
  • Cynthia A Carnes
  • Life Sci..2020 Jan;240:117068. S0024-3205(19)30995-6. doi: 10.1016/j.lfs.2019.117068.Epub 2019-11-18.

伝統医学で使用される植物であるCymbopogon nardusの精油の化学組成、抗酸化作用、抗炎症作用、抗増殖作用

Chemical composition, antioxidant, anti-inflammatory and antiproliferative activities of the essential oil of Cymbopogon nardus, a plant used in traditional medicine.
  • Bagora Bayala
  • Ahmed Y Coulibaly
  • Florencia W Djigma
  • Bolni Marius Nagalo
  • Silvère Baron
  • Gilles Figueredo
  • Jean-Marc A Lobaccaro
  • Jacques Simpore
  • Biomol Concepts.2020 Apr;11(1):86-96. /j/bmc.2020.11.issue-1/bmc-2020-0007/bmc-2020-0007.xml. doi: 10.1515/bmc-2020-0007.Epub 2020-04-15.

難治性気胸、気管支瘻を伴う気胸、術後の空気漏れに対する内視鏡的気管支閉塞術の臨床的評価

The Clinical Evaluation of Endoscopic Bronchial Occlusion with an Endobronchial Watanabe Spigot for the Management of Intractable Pneumothorax, Pyothorax with Bronchial Fistula, and Postoperative Air Leakage.
  • Daisuke Himeji
  • Gen-Ichi Tanaka
  • Chikara Fukuyama
  • Ritsuya Shiiba
  • Atsushi Yamanaka
  • Kiichiro Beppu
  • Intern. Med..2020 Apr;doi: 10.2169/internalmedicine.3900-19.Epub 2020-04-30.

Tracheobronchial Slough, a Potential Pathology in Endotracheal Tube Obstruction in Patients With Coronavirus Disease 2019 (COVID-19) in Intensive Care Setting

Tracheobronchial Slough, a Potential Pathology in Endotracheal Tube Obstruction in Patients With Coronavirus Disease 2019 (COVID-19) in the Intensive Care Setting.
  • Jerry A Rubano
  • Patrick T Jasinski
  • Daniel N Rutigliano
  • Apostolos K Tassiopoulos
  • James E Davis
  • Tazeen Beg
  • Shaji Poovathoor
  • Sergio D Bergese
  • Sahar Ahmad
  • Randeep S Jawa
  • James A Vosswinkel
  • Mark A Talamini
  • Ann. Surg..2020 May;doi: 10.1097/SLA.0000000000004031.Epub 2020-05-20.