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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

運動時の体温上昇は、2型糖尿病ラットの骨格筋におけるAktシグナル伝達経路の活性化に不可欠である

Body temperature elevation during exercise is essential for activating the Akt signaling pathway in the skeletal muscle of type 2 diabetic rats.
  • Takamasa Tsuzuki
  • Toshinori Yoshihara
  • Noriko Ichinoseki-Sekine
  • Ryo Kakigi
  • Yuri Takamine
  • Hiroyuki Kobayashi
  • Hisashi Naito
  • PLoS ONE.2018;13(10):e0205456. PONE-D-18-18834. doi: 10.1371/journal.pone.0205456.Epub 2018-10-10.

NSAID増悪性呼吸器疾患における炎症性マクロファージの記憶

Inflammatory macrophage memory in NSAID-exacerbated respiratory disease.
  • Pascal Haimerl
  • Ulrike Bernhardt
  • Sonja Schindela
  • Fiona Dr Henkel
  • Antonie Lechner
  • Ulrich M Zissler
  • Xavier Pastor
  • Dominique Thomas
  • Alexander Cecil
  • Yan Ge
  • Mark Haid
  • Cornelia Prehn
  • Janina Tokarz
  • Matthias Heinig
  • Jerzy Adamski
  • Carsten B Schmidt-Weber
  • Adam M Chaker
  • Julia Esser-von Bieren
  • J. Allergy Clin. Immunol..2020 Jun;S0091-6749(20)30803-4. doi: 10.1016/j.jaci.2020.04.064.Epub 2020-06-12.

コアシェルポリ(D,l-ラクチド-コ-グリコリド)-キトサンナノスフェアとシムバスタチン-ドキシサイクリンを用いた歯周および骨修復のためのコアシェルキトサンナノスフェア

Core-Shell poly-(D,l-Lactide-co-Glycolide)-chitosan Nanospheres with simvastatin-doxycycline for periodontal and osseous repair.
  • Po-Chun Chang
  • Wei-Chiu Tai
  • Hui-Ting Luo
  • Chern-Hsiung Lai
  • Hsu-Hsiang Lin
  • Zhi-Jie Lin
  • Ying-Chieh Chang
  • Bor-Shiunn Lee
  • Int. J. Biol. Macromol..2020 May;158:627-635. S0141-8130(20)33043-9. doi: 10.1016/j.ijbiomac.2020.04.183.Epub 2020-05-07.

Ad5 ベクター化 HIV ワクチン接種者における粘膜 T 細胞の長期的な活性化とホーミング表現型

Long-term mucosal T cell activation and homing phenotypes in recipients of an Ad5-vectored HIV vaccine.
  • Marcel E Curlin
  • Jason Shao
  • Gabriela Diaz
  • Paul T Edlefsen
  • Richard M Novak
  • Kenneth H Mayer
  • Mary Allen
  • Cecilia Morgan
  • Janine Maenza
  • Susan Buchbinder
  • Michael C Keefer
  • Stephen C De Rosa
  • Lawrence Corey
  • Ann Duerr
  • Vaccine.2020 Jul;S0264-410X(20)30829-X. doi: 10.1016/j.vaccine.2020.06.043.Epub 2020-07-14.

ネオアジュバント化学療法後の乳癌における腋窩ステージングの問題点。標的腋窩郭清の役割とリンパ節マーカーの種類

The problem of axillary staging in breast cancer after neoadjuvant chemotherapy. Role of targeted axillary dissection and types of lymph node markers.
  • Diego Flores-Funes
  • José Aguilar-Jiménez
  • María Martínez-Gálvez
  • María José Ibáñez-Ibáñez
  • Luis Carrasco-González
  • José Ignacio Gil-Izquierdo
  • José Luis Aguayo-Albasini
  • Cir Esp.2020 May;S0009-739X(20)30097-X. doi: 10.1016/j.ciresp.2020.03.012.Epub 2020-05-05.

電気熱原子吸光分析法を用いた液相マイクロ抽出をベースとした環境に優しい超音波支援型深層共晶溶媒による水中および生物学的試料中の水銀のスペシエーション

Speciation of mercury in water and biological samples by eco-friendly ultrasound-assisted deep eutectic solvent based on liquid phase microextraction with electrothermal atomic absorption spectrometry.
  • Arnon Thongsaw
  • Yuthapong Udnan
  • Gareth M Ross
  • Wipharat Chuachuad Chaiyasith
  • Talanta.2019 May;197:310-318. S0039-9140(19)30018-9. doi: 10.1016/j.talanta.2019.01.018.Epub 2019-01-09.

三酸化ヒ素はインターフェロン阻害を介して形質細胞性樹状細胞の調節機能を誘導する

Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- inhibition.
  • Yishan Ye
  • Laure Ricard
  • Lama Siblany
  • Nicolas Stocker
  • Frédéric De Vassoigne
  • Eolia Brissot
  • Baptiste Lamarthée
  • Arsène Mekinian
  • Mohamad Mohty
  • Béatrice Gaugler
  • Florent Malard
  • Acta Pharm Sin B.2020 Jun;10(6):1061-1072. S2211-3835(19)30954-2. doi: 10.1016/j.apsb.2020.01.016.Epub 2020-01-31.

HNF1A糖尿病(3型若年者の成熟期糖尿病)患者におけるリナグリプチン治療の有無にかかわらずグリメピリドの有効性と安全性。A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA)

Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA).
  • Alexander S Christensen
  • Sofie Hædersdal
  • Julie Støy
  • Heidi Storgaard
  • Ulla Kampmann
  • Julie L Forman
  • Marta Seghieri
  • Jens J Holst
  • Torben Hansen
  • Filip K Knop
  • Tina Vilsbøll
  • Diabetes Care.2020 Jul;dc200408. doi: 10.2337/dc20-0408.Epub 2020-07-13.

メンサピペリタ精油への連続暴露は、持続的に流行するサルモネラ菌PT4の培養性に影響を与え、膜修復を誘導することがわかった

Successive exposure to Mentha piperita L. essential oil affects the culturability and induces membrane repair in a persister epidemic Salmonella Typhimurium PT4.
  • Adma Nadja Ferreira de Melo
  • Geany Targino de Souza Pedrosa
  • Erika Tayse da Cruz Almeida
  • Guojie Cao
  • Dumitru Macarisin
  • Donald W Schaffner
  • Evandro L de Souza
  • Marciane Magnani
  • Microb. Pathog..2020 May;149:104264. S0882-4010(20)30630-6. doi: 10.1016/j.micpath.2020.104264.Epub 2020-05-25.

花粉がインフルエンザ様の流行を抑制する季節的要因と思われる花粉の数と花粉症とインフルエンザ様発症率の逆関係を調べたオランダの研究 2016-2019年

Pollen likely seasonal factor in inhibiting flu-like epidemics. A Dutch study into the inverse relation between pollen counts, hay fever and flu-like incidence 2016-2019.
  • Martijn J Hoogeveen
  • Sci. Total Environ..2020 Jul;727:138543. S0048-9697(20)32056-8. doi: 10.1016/j.scitotenv.2020.138543.Epub 2020-04-17.

モリンガオレイフェラ茎(MOS)加工飼料を給与した場合の産卵鴨の成長・産卵成績および免疫・抗酸化活性に及ぼす影響

Effects of feeding diets with processed Moringa oleifera stem meal on growth and laying performance, and immunological and antioxidant activities in laying ducks.
  • S L Yang
  • R C Yang
  • X Zhou
  • S H Yang
  • L L Luo
  • Y C Zhu
  • Surintorn Boonanuntan
  • Poult. Sci..2020 Jul;99(7):3445-3451. S0032-5791(20)30238-8. doi: 10.1016/j.psj.2020.04.002.Epub 2020-04-24.

CFTR補正装置ABBV-2222/GLPG2222によるF508delCFTRタンパク質プロセシングの生物学的特性評価

Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222.
  • Ashvani K Singh
  • Yihong Fan
  • Corina Balut
  • Sara Alani
  • Arlene M Manelli
  • Andrew M Swensen
  • Ying Jia
  • Torben R Neelands
  • Timothy A Vortherms
  • Bo Liu
  • Xenia B Searle
  • Xueqing Wang
  • Wenqing Gao
  • Tzyh-Chang Hwang
  • Hong Y Ren
  • Douglas Cyr
  • Philip R Kym
  • Katja Conrath
  • Chris Tse
  • J. Pharmacol. Exp. Ther..2020 01;372(1):107-118. jpet.119.261800. doi: 10.1124/jpet.119.261800.Epub 2019-11-15.

妊娠中の食事因子と小児期のアトピーの転帰:アレルギーと臨床免疫学の欧州アカデミーからの系統的レビュー

Dietary factors during pregnancy and atopic outcomes in childhood: a systematic review from the European Academy of Allergy and Clinical Immunology.
  • C Venter
  • C Agostoni
  • S H Arshad
  • M Ben-Abdallah
  • G Du Toit
  • D M Fleischer
  • M Greenhawt
  • D H Glueck
  • M Groetch
  • N Lunjani
  • K Maslin
  • A Maiorella
  • R Meyer
  • A Muraro
  • M J Netting
  • B I Nwaru
  • D J Palmer
  • M P Palumbo
  • G Roberts
  • C Roduit
  • P K Smith
  • E Untersmayr
  • L Vanderlinden
  • L O'Mahony
  • Pediatr Allergy Immunol.2020 Jun;doi: 10.1111/pai.13303.Epub 2020-06-10.

漢方薬Radix Paeoniae Rubraがアラキドン酸経路のPTGS2を調節して慢性骨盤内炎症疾患を改善するメカニズムの研究

Research on the mechanism of Chinese herbal medicine Radix Paeoniae Rubra in improving chronic pelvic inflammation disease by regulating PTGS2 in the arachidonic acid pathway.
  • Xiao-Hong Li
  • Yan-Ru Liu
  • Da-Hai Jiang
  • Zhi-Shu Tang
  • Da-Wei Qian
  • Zhong-Xing Song
  • Lin Chen
  • Xin-Bo Shi
  • Ning-Juan Yang
  • Ya-Feng Yan
  • Ai-Bing Chang
  • Biomed. Pharmacother..2020 Jun;129:110052. S0753-3322(20)30243-2. doi: 10.1016/j.biopha.2020.110052.Epub 2020-06-16.

心房間ブロック、左房線維症、機械的同期不全との関連性:心電図と磁気共鳴画像の相関

Association between interatrial block, left atrial fibrosis, and mechanical dyssynchrony: Electrocardiography-magnetic resonance imaging correlation.
  • Luisa Ciuffo
  • Vanesa Bruña
  • Manuel Martínez-Sellés
  • Henrique Doria de Vasconcellos
  • Susumu Tao
  • Tarek Zghaib
  • Saman Nazarian
  • David D Spragg
  • Joseph Marine
  • Ronald D Berger
  • Joao A C Lima
  • Hugh Calkins
  • Antonio Bayés-de-Luna
  • Hiroshi Ashikaga
  • J. Cardiovasc. Electrophysiol..2020 Jul;31(7):1719-1725. doi: 10.1111/jce.14608.Epub 2020-06-15.

悪性胸膜中皮腫におけるBAP-1免疫組織化学の予後的役割を問う。システマティックレビューとメタアナリシスを用いた単一施設の経験

Questioning the prognostic role of BAP-1 immunohistochemistry in malignant pleural mesothelioma: A single center experience with systematic review and meta-analysis.
  • Luca Cantini
  • Federica Pecci
  • Alberto Murrone
  • Marco Tomasetti
  • Cecilia Copparoni
  • Ilaria Fiordoliva
  • Francesca Morgese
  • Silvia Rinaldi
  • Paola Mazzanti
  • Corrado Rubini
  • Alessia Cimadamore
  • Francesca Barbisan
  • Riccardo Giampieri
  • Marina Scarpelli
  • Lory Santarelli
  • Rossana Berardi
  • Lung Cancer.2020 Aug;146:318-326. S0169-5002(20)30498-0. doi: 10.1016/j.lungcan.2020.06.024.Epub 2020-06-21.

G3BPの分離ドメインは、アルファウイルス複製複合体の効率的なクラスタリングと翻訳開始機構のリクルートを促進する

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.
  • Benjamin Götte
  • Marc D Panas
  • Kirsi Hellström
  • Lifeng Liu
  • Baila Samreen
  • Ola Larsson
  • Tero Ahola
  • Gerald M McInerney
  • PLoS Pathog..2019 06;15(6):e1007842. PPATHOGENS-D-19-00011. doi: 10.1371/journal.ppat.1007842.Epub 2019-06-14.

背側根神経節ニューロンのサブクラスの機能分類を容易に行うための統合的アプローチ

An integrative approach to the facile functional classification of dorsal root ganglion neuronal subclasses.
  • Mario J Giacobassi
  • Lee S Leavitt
  • Shrinivasan Raghuraman
  • Rishi Alluri
  • Kevin Chase
  • Rocio K Finol-Urdaneta
  • Heinrich Terlau
  • Russell W Teichert
  • Baldomero M Olivera
  • Proc. Natl. Acad. Sci. U.S.A..2020 03;117(10):5494-5501. 1911382117. doi: 10.1073/pnas.1911382117.Epub 2020-02-20.

患者が他の患者を助ける。孤児院では、「ハンセン病患者が他の患者を助ける」ことを目的とした研究が行われています

Patients help other patients: Qualitative study on a longstanding community cooperative to tackle leprosy in India.
  • Seong Hye Jung
  • Hee Won Han
  • Hyeonseok Koh
  • Soo-Young Yu
  • Nobutoshi Nawa
  • Ayako Morita
  • Ken Ing Cherng Ong
  • Masamine Jimba
  • Juhwan Oh
  • PLoS Negl Trop Dis.2020 01;14(1):e0008016. PNTD-D-19-00319. doi: 10.1371/journal.pntd.0008016.Epub 2020-01-13.

気管支肺胞胆汁酸および炎症性マーカーを測定し、逆流および微小吸引を有する高リスク肺移植患者を同定した

Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration.
  • Chen Yang Kevin Zhang
  • Musawir Ahmed
  • Ella Huszti
  • Liran Levy
  • Sarah E Hunter
  • Kristen M Boonstra
  • Sajad Moshkelgosha
  • Andrew T Sage
  • Sassan Azad
  • Ricardo Zamel
  • Rasheed Ghany
  • Jonathan C Yeung
  • Oscar M Crespin
  • Courtney Frankel
  • Marie Budev
  • Pali Shah
  • John M Reynolds
  • Laurie D Snyder
  • John A Belperio
  • Lianne G Singer
  • S Samuel Weigt
  • Jamie L Todd
  • Scott M Palmer
  • Shaf Keshavjee
  • Tereza Martinu
  • J. Heart Lung Transplant..2020 May;S1053-2498(20)31558-8. doi: 10.1016/j.healun.2020.05.006.Epub 2020-05-19.

肥満者の脂肪組織におけるビタミンD受容体遺伝子発現はmiRNAによって制御され、プロ炎症性サイトカインレベルと相関する

Vitamin D Receptor Gene Expression in Adipose Tissue of Obese Individuals is Regulated by miRNA and Correlates with the Pro-Inflammatory Cytokine Level.
  • Marta Izabela Jonas
  • Alina Kuryłowicz
  • Zbigniew Bartoszewicz
  • Wojciech Lisik
  • Maurycy Jonas
  • Krzysztof Kozniewski
  • Monika Puzianowska-Kuznicka
  • Int J Mol Sci.2019 Oct;20(21). E5272. doi: 10.3390/ijms20215272.Epub 2019-10-24.

FAK活性はプラチナ化学療法に対する本質的および後天的な卵巣癌抵抗性を維持する

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.
  • Carlos J Diaz Osterman
  • Duygu Ozmadenci
  • Elizabeth G Kleinschmidt
  • Kristin N Taylor
  • Allison M Barrie
  • Shulin Jiang
  • Lisa M Bean
  • Florian J Sulzmaier
  • Christine Jean
  • Isabelle Tancioni
  • Kristen Anderson
  • Sean Uryu
  • Edward A Cordasco
  • Jian Li
  • Xiao Lei Chen
  • Guo Fu
  • Marjaana Ojalill
  • Pekka Rappu
  • Jyrki Heino
  • Adam M Mark
  • Guorong Xu
  • Kathleen M Fisch
  • Vihren N Kolev
  • David T Weaver
  • Jonathan A Pachter
  • Balázs Győrffy
  • Michael T McHale
  • Denise C Connolly
  • Alfredo Molinolo
  • Dwayne G Stupack
  • David D Schlaepfer
  • Elife.2019 09;8. e47327. doi: 10.7554/eLife.47327.Epub 2019-09-03.

地中海式ダイエットと更年期の健康。EMASのポジションステートメント

The Mediterranean diet and menopausal health: An EMAS position statement.
  • Antonio Cano
  • Skye Marshall
  • Irene Zolfaroli
  • Johannes Bitzer
  • Iuliana Ceausu
  • Peter Chedraui
  • Fatih Durmusoglu
  • Risto Erkkola
  • Dimitrios G Goulis
  • Angelica Lindén Hirschberg
  • Ludwig Kiesel
  • Patrice Lopes
  • Amos Pines
  • Mick van Trotsenburg
  • Irene Lambrinoudaki
  • Margaret Rees
  • Maturitas.2020 Jul;S0378-5122(20)30325-X. doi: 10.1016/j.maturitas.2020.07.001.Epub 2020-07-13.

未治療の濾胞性リンパ腫を対象としたBendamustine/RituximabとBortezomib導入またはLenalidomide継続併用の3アーム無作為化第II相試験。ECOG-ACRIN E2408

A Three-Arm Randomized Phase II Study of Bendamustine/Rituximab with Bortezomib Induction or Lenalidomide Continuation in Untreated Follicular Lymphoma: ECOG-ACRIN E2408.
  • Andrew M Evens
  • Fangxin Hong
  • Thomas M Habermann
  • Ranjana H Advani
  • Randy D Gascoyne
  • Thomas E Witzig
  • Andrew Quon
  • Erik A Ranheim
  • Stephen M Ansell
  • Puneet Singh Cheema
  • Philip A Dy
  • Timothy E O'Brien
  • Jane N Winter
  • Terrence P Cescon
  • Julie E Chang
  • Brad S Kahl
  • Clin. Cancer Res..2020 Jun;1078-0432.CCR-20-1345. doi: 10.1158/1078-0432.CCR-20-1345.Epub 2020-06-12.

常染色体優性多嚢胞性腎疾患における腎予後予測における画像分類に加えて尿中アンジオテンシノーゲン

Urinary Angiotensinogen in addition to Imaging Classification in the Prediction of Renal Outcome in Autosomal Dominant Polycystic Kidney Disease.
  • Hayne Cho Park
  • Juhee Kim
  • AJin Cho
  • Do Hyoung Kim
  • Young Ki Lee
  • Hyunjin Ryu
  • Hyunsuk Kim
  • Kook Hwan Oh
  • Yun Kyu Oh
  • Young Hwan Hwang
  • Kyu Beck Lee
  • Soo Wan Kim
  • Yeong Hoon Kim
  • Joongyub Lee
  • Curie Ahn
  • J. Korean Med. Sci..2020 Jun;35(22):e165. 35.e165. doi: 10.3346/jkms.2020.35.e165.Epub 2020-06-08.

保健システムパフォーマンス評価(IPHA)への人口視点の統合。ドイツにおける横断的研究のための研究プロトコル

Integrating the Population Perspective into Health System Performance Assessment (IPHA): Study Protocol for a Cross-Sectional Study in Germany Linking Survey and Claims Data of Statutorily and Privately Insured.
  • Miriam Blümel
  • Julia Röttger
  • Julia Köppen
  • Katharina Achstetter
  • Reinhard Busse
  • Int J Health Policy Manag.2020 Jan;doi: 10.15171/ijhpm.2019.141.Epub 2020-01-20.

トレーニングによるAT受容体経路の不活性化は、高血圧ラットの高血圧前から高血圧期への移行期に自律神経制御と心臓のリモデリングを促進する

Training-Induced Deactivation of the AT Receptor Pathway Drives Autonomic Control and Heart Remodeling During the Transition From the Pre- to Hypertensive Phase in Spontaneously Hypertensive Rats.
  • Tassia Santos Rodrigues da Costa
  • Gustavo Santos Masson
  • Rosangela Aparecida Dos Santos Eichler
  • Juliane Cristina de Souza Silva
  • Silvia Lacchini
  • Lisete Compagno Michelini
  • Circ. J..2020 Jun;doi: 10.1253/circj.CJ-19-1161.Epub 2020-06-10.

複合飼料を給与した北京ダックの成長成績、枝肉形質、肉質、栄養利用率、アミノ酸の標準化された回腸消化率に及ぼす飼料タンパク質量とプロテアーゼ添加の影響

Effects of dietary protein levels and protease supplementation on growth performance, carcass traits, meat quality, and standardized ileal digestibility of amino acid in Pekin ducks fed a complex diet.
  • Q D Wang
  • K Y Zhang
  • Y Zhang
  • S P Bai
  • X M Ding
  • J P Wang
  • H W Peng
  • G Tian
  • Y Xuan
  • Z W Su
  • Q F Zeng
  • Poult. Sci..2020 Jul;99(7):3557-3566. S0032-5791(20)30223-6. doi: 10.1016/j.psj.2020.03.047.Epub 2020-04-27.

新生児臨床発作に対するレベチラセタムとフェノバルビタールの単剤治療を受けた期の乳児の神経認知転帰の比較

Comparison of the neurocognitive outcomes in term infants treated with levetiracetam and phenobarbital monotherapy for neonatal clinical seizures.
  • Pinar Arican
  • Nihal Olgac Dundar
  • Neslihan Mete Atasever
  • Mine Akkaya Inal
  • Pinar Gencpinar
  • Dilek Cavusoglu
  • Sinem Akbay
  • Hasan Tekgul
  • Seizure.2020 Jun;80:71-74. S1059-1311(20)30168-0. doi: 10.1016/j.seizure.2020.06.006.Epub 2020-06-05.

クロトニル化が重要な代謝酵素のクロトニル化を制御することで、ストレプトミセス・ロゾスポラスの炭素異化抑制が可能になることを明らかにした

Crotonylation of key metabolic enzymes regulates carbon catabolite repression in Streptomyces roseosporus.
  • Chen-Fan Sun
  • Wei-Feng Xu
  • Qing-Wei Zhao
  • Shuai Luo
  • Xin-Ai Chen
  • Yong-Quan Li
  • Xu-Ming Mao
  • Commun Biol.2020 Apr;3(1):192. 10.1038/s42003-020-0924-2. doi: 10.1038/s42003-020-0924-2.Epub 2020-04-24.

HIV-1逆転写酵素は、ツイストの活性酸素依存性アップレギュレーションを介して腫瘍の成長と転移形成を促進する

HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist.
  • Ekaterina Bayurova
  • Juris Jansons
  • Dace Skrastina
  • Olga Smirnova
  • Dzeina Mezale
  • Anastasia Kostyusheva
  • Dmitry Kostyushev
  • Stefan Petkov
  • Philip Podschwadt
  • Vladimir Valuev-Elliston
  • Sviataslau Sasinovich
  • Sergey Korolev
  • Per Warholm
  • Anastasia Latanova
  • Elizaveta Starodubova
  • Amir Tukhvatulin
  • Oleg Latyshev
  • Renat Selimov
  • Pavel Metalnikov
  • Alexander Komarov
  • Olga Ivanova
  • Tatiana Gorodnicheva
  • Sergey Kochetkov
  • Marina Gottikh
  • Ilze Strumfa
  • Alexander Ivanov
  • Ilya Gordeychuk
  • Maria Isaguliants
  • Oxid Med Cell Longev.2019;2019:6016278. doi: 10.1155/2019/6016278.Epub 2019-12-02.

単細胞トランスクリプトミクスを用いた乳がんにおける骨髄由来サプレッサー細胞の出現の定義

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics.
  • Hamad Alshetaiwi
  • Nicholas Pervolarakis
  • Laura Lynn McIntyre
  • Dennis Ma
  • Quy Nguyen
  • Jan Akara Rath
  • Kevin Nee
  • Grace Hernandez
  • Katrina Evans
  • Leona Torosian
  • Anushka Silva
  • Craig Walsh
  • Kai Kessenbrock
  • Sci Immunol.2020 02;5(44). eaay6017. doi: 10.1126/sciimmunol.aay6017.

異化分業は、工学的共培養システムにおけるグルコース-キシロース混合物からのD-乳酸およびコハク酸の生産を向上させる

Catabolic Division of Labor Enhances Production of D-Lactate and Succinate From Glucose-Xylose Mixtures in Engineered Co-culture Systems.
  • Andrew D Flores
  • Hyun G Choi
  • Rodrigo Martinez
  • Moses Onyeabor
  • E Zeynep Ayla
  • Amanda Godar
  • Michael Machas
  • David R Nielsen
  • Xuan Wang
  • Front Bioeng Biotechnol.2020;8:329. doi: 10.3389/fbioe.2020.00329.Epub 2020-05-05.

赤血球AE1/バンド3トランスポートが優性遠位性腎性尿細管アシドーシス患者に認められた

Red Blood Cell AE1/Band 3 Transports in Dominant Distal Renal Tubular Acidosis Patients.
  • Jean-Philippe Bertocchio
  • Sandrine Genetet
  • Lydie Da Costa
  • Stephen B Walsh
  • Bertrand Knebelmann
  • Julie Galimand
  • Lucie Bessenay
  • Corinne Guitton
  • Renaud De Lafaille
  • Rosa Vargas-Poussou
  • Dominique Eladari
  • Isabelle Mouro-Chanteloup
  • Kidney Int Rep.2020 Mar;5(3):348-357. S2468-0249(20)30007-3. doi: 10.1016/j.ekir.2019.12.020.Epub 2020-01-13.

2番染色体2p11.2での再発性微小欠失は、胸腺低形成とDiGeorge症候群に類似した特徴と関連している

Recurrent microdeletions at chromosome 2p11.2 are associated with thymic hypoplasia and features resembling DiGeorge syndrome.
  • Joshua D Bernstock
  • Arthur H Totten
  • Abdel G Elkahloun
  • Kory R Johnson
  • Anna C Hurst
  • Frederick Goldman
  • Andrew K Groves
  • Fady M Mikhail
  • T Prescott Atkinson
  • J. Allergy Clin. Immunol..2020 Jan;145(1):358-367.e2. S0091-6749(19)31256-4. doi: 10.1016/j.jaci.2019.09.020.Epub 2019-10-07.

高分解能質量分析法によるAverrhoa carambola L.樹皮中の二次代謝物の同定とα-グルコシダーゼ、チロシナーゼ、エラスターゼ、抗酸化力の評価

Identification of secondary metabolites in Averrhoa carambola L. bark by high-resolution mass spectrometry and evaluation for α-glucosidase, tyrosinase, elastase, and antioxidant potential.
  • Syful Islam
  • Md Badrul Alam
  • Arif Ahmed
  • Seulgidaun Lee
  • Sang-Han Lee
  • Sunghwan Kim
  • Food Chem.2020 Jun;332:127377. S0308-8146(20)31239-5. doi: 10.1016/j.foodchem.2020.127377.Epub 2020-06-23.

HIV-1サブタイプC逆転写酵素阻害のための天然物スクリーニングのためのシュードウイルスアッセイ法の開発と評価

Development of a pseudovirus assay and evaluation to screen natural products for inhibition of HIV-1 subtype C reverse transcriptase.
  • Lufuno Grace Mavhandu
  • Hua Cheng
  • Yeou-Cheng Bor
  • Denis Manga Tebit
  • Marie-Louise Hammarskjold
  • David Rekosh
  • Pascal Obong Bessong
  • J Ethnopharmacol.2020 Aug;258:112931. S0378-8741(20)30780-7. doi: 10.1016/j.jep.2020.112931.Epub 2020-04-30.

ブラジル,サンパウロの大規模総合病院における定期的なカルテ監査の評価者間の一致度をプロスペクティブに評価したもの.

A prospective evaluation of inter-rater agreement of routine medical records audits at a large general hospital in São Paulo, Brazil.
  • Ana Carolina Cintra Nunes Mafra
  • João Luiz Miraglia
  • Fernando Antonio Basile Colugnati
  • Gilberto Soares Lourenço Padilha
  • Renata Rafaella Santos Tadeucci
  • Ederson Almeida
  • Mario Maia Bracco
  • BMC Health Serv Res.2020 Jul;20(1):638. 10.1186/s12913-020-05495-w. doi: 10.1186/s12913-020-05495-w.Epub 2020-07-10.

菱形脳シナプス症、三叉神経節の突発性および視細胞腫(脱毛症を伴わない)を呈した小児:小脳三叉神経皮膚異形成症の一変か?

A child with rhombencephalosynapsis, agenesis of the trigeminal ganglion and optic coloboma (without alopecia): a variant of the cerebellotrigeminal dermal dysplasia?
  • Federica Sullo
  • Stefano Palmucci
  • Agata Polizzi
  • Martino Ruggieri
  • Andrea D Praticò
  • Clin. Dysmorphol..2020 Jul;doi: 10.1097/MCD.0000000000000333.Epub 2020-07-10.

Klf9 は、グルココルチコイド受容体活性に対するトランスクリプトーム応答を制御する重要なフィードフォワード制御因子である

Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity.
  • Ian Gans
  • Ellen I Hartig
  • Shusen Zhu
  • Andrea R Tilden
  • Lucie N Hutchins
  • Nathaniel J Maki
  • Joel H Graber
  • James A Coffman
  • Sci Rep.2020 Jul;10(1):11415. 10.1038/s41598-020-68040-z. doi: 10.1038/s41598-020-68040-z.Epub 2020-07-10.

QbD(Quality by Design)アプローチを用いたリバスチグミンを搭載したナノ構造脂質キャリア(NLC)の鼻から脳への送達のための二重最適化。配合変数と機器パラメータ

Double Optimization of Rivastigmine-Loaded Nanostructured Lipid Carriers (NLC) for Nose-to-Brain Delivery Using the Quality by Design (QbD) Approach: Formulation Variables and Instrumental Parameters.
  • Sara Cunha
  • Cláudia Pina Costa
  • Joana A Loureiro
  • Jorge Alves
  • Andreia F Peixoto
  • Ben Forbes
  • José Manuel Sousa Lobo
  • Ana Catarina Silva
  • Pharmaceutics.2020 Jun;12(7). E599. doi: 10.3390/pharmaceutics12070599.Epub 2020-06-28.

鉄硫黄クラスター生合成タンパク質HSCBの変異は、先天性唾液性貧血の原因となる

Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia.
  • Andrew Crispin
  • Chaoshe Guo
  • Caiyong Chen
  • Dean R Campagna
  • Paul J Schmidt
  • Daniel A Lichtenstein
  • Chang Cao
  • Anoop K Sendamarai
  • Gordon J Hildick-Smith
  • Nicholas C Huston
  • Jeanne Boudreaux
  • Sylvia S Bottomley
  • Matthew M Heeney
  • Barry H Paw
  • Mark D Fleming
  • Sarah Ducamp
  • J. Clin. Invest..2020 Jul;135479. doi: 10.1172/JCI135479.Epub 2020-07-07.

HRAS遺伝子変異を有する前治療歴のある転移性尿路粘膜癌患者を対象としたティピファルニブの第II相試験

A phase II trial of tipifarnib for patients with previously-treated, metastatic urothelial carcinoma harboring HRAS mutations.
  • Hye Won Lee
  • Jason Kyungha Sa
  • Antonio Gualberto
  • Catherine Scholz
  • Hyun Hwan Sung
  • Byong Chang Jeong
  • Han Yong Choi
  • Ghee Young Kwon
  • Se Hoon Park
  • Clin. Cancer Res..2020 Jul;clincanres.1246.2020. doi: 10.1158/1078-0432.CCR-20-1246.Epub 2020-07-07.

"若い妊娠中の少女として...あなたが直面する課題"南アフリカの思春期の少女と若い女性の間のメンタルヘルスと性とリプロダクティブヘルスの交錯を探る

"As a Young Pregnant Girl… The Challenges You Face": Exploring the Intersection Between Mental Health and Sexual and Reproductive Health Amongst Adolescent Girls and Young Women in South Africa.
  • Zoe Duby
  • Tracy McClinton Appollis
  • Kim Jonas
  • Kealeboga Maruping
  • Janan Dietrich
  • Ashleigh LoVette
  • Caroline Kuo
  • Lieve Vanleeuw
  • Catherine Mathews
  • AIDS Behav.2020 Jul;10.1007/s10461-020-02974-3. doi: 10.1007/s10461-020-02974-3.Epub 2020-07-18.

小児多発性硬化症患者におけるリンパ球数の時間的プロファイルとフィンゴリモド療法による感染症との関連。PARADIG試験の結果

Temporal profile of lymphocyte counts and relationship with infections with fingolimod therapy in paediatric patients with multiple sclerosis: Results from the PARADIG study.
  • Tanuja Chitnis
  • Brenda Banwell
  • Lauren Krupp
  • Douglas L Arnold
  • Amit Bar-Or
  • Wolfgang Brück
  • Gavin Giovannoni
  • Benjamin Greenberg
  • Angelo Ghezzi
  • Emmanuelle Waubant
  • Kevin Rostasy
  • Kumaran Deiva
  • Peter Huppke
  • Jerry S Wolinsky
  • Ying Zhang
  • Amin Azmon
  • Annik K-Laflamme
  • Rajesh Karan
  • Jutta Gärtner
  • Mult. Scler..2020 Jul;:1352458520936934. doi: 10.1177/1352458520936934.Epub 2020-07-07.