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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

子宮筋腫に対する超音波ガイド下高強度集束超音波(USgHIFU)アブレーションと腹腔鏡下子宮筋腫切除術の妊娠転帰の比較:比較研究

A comparison of the pregnancy outcomes between ultrasound-guided high-intensity focused ultrasound ablation and laparoscopic myomectomy for uterine fibroids: a comparative study.
  • Guangping Wu
  • Rong Li
  • Min He
  • Yuanfang Pu
  • Jishu Wang
  • Jinyun Chen
  • Hongbo Qi
  • Int J Hyperthermia.2020;37(1):617-623. doi: 10.1080/02656736.2020.1774081.

頭頸部扁平上皮癌の再発性または転移性頭頸部扁平上皮癌を対象としたTalimogene LaherparepvecとPembrolizumabの併用療法(MASTERKEY-232)。多施設共同第1b相試験

Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study.
  • Kevin J Harrington
  • Anthony Kong
  • Nicolas Mach
  • Jason Chesney
  • Beatriz Castelo Fernandez
  • Danny Rischin
  • Ezra E W Cohen
  • Hoi-Shen Radcliffe
  • Burak Gumuscu
  • Jonathan Cheng
  • Wendy Snyder
  • Lillian L Siu
  • Clin. Cancer Res..2020 Jul;clincanres.1170.2020. doi: 10.1158/1078-0432.CCR-20-1170.Epub 2020-07-15.

爪真菌症の治療におけるフラクショナル2940nm Er:YAGレーザーと5%アモロルフィンラッカーの併用療法と5%アモロルフィンラッカー単剤療法の比較:無作為化比較試験

Comparison of a fractional 2940-nm Er:YAG laser and 5% amorolfine lacquer combination therapy versus a 5% amorolfine lacquer monotherapy for the treatment of onychomycosis: a randomized controlled trial.
  • Jing Zhang
  • Yunqing Zhang
  • Jinglin Qin
  • Sha Lu
  • Wenying Cai
  • Jiahao Li
  • Huaiqiu Huang
  • Sulian Yang
  • Liyan Xi
  • Lasers Med Sci.2020 Jun;10.1007/s10103-020-03054-7. doi: 10.1007/s10103-020-03054-7.Epub 2020-06-17.

喘息患者および健康な個体における家畜農場からの粒子状物質に対する生体外自然応答

Ex vivo innate responses to particulate matter from livestock farms in asthma patients and healthy individuals.
  • Linsey E S de Groot
  • Dingyu Liu
  • Barbara S Dierdorp
  • Niki Fens
  • Marianne A van de Pol
  • Peter J Sterk
  • Wim Kulik
  • Miriam E Gerlofs-Nijland
  • Flemming R Cassee
  • Elena Pinelli
  • René Lutter
  • Environ Health.2020 Jul;19(1):78. 10.1186/s12940-020-00632-8. doi: 10.1186/s12940-020-00632-8.Epub 2020-07-03.

マダガスカルの白亜紀哺乳類の骨格は長期的な不規則性を反映している

Skeleton of a Cretaceous mammal from Madagascar reflects long-term insularity.
  • David W Krause
  • Simone Hoffmann
  • Yaoming Hu
  • John R Wible
  • Guillermo W Rougier
  • E Christopher Kirk
  • Joseph R Groenke
  • Raymond R Rogers
  • James B Rossie
  • Julia A Schultz
  • Alistair R Evans
  • Wighart von Koenigswald
  • Lydia J Rahantarisoa
  • Nature.2020 05;581(7809):421-427. 10.1038/s41586-020-2234-8. doi: 10.1038/s41586-020-2234-8.Epub 2020-04-29.

イネ科コイの遺伝子型II型イネ科レオウイルス感染後の臨床症状,ウイルス分布,抗ウイルス免疫関連遺伝子のmRNA発現に関する研究

Studies on the clinical symptoms, virus distribution, and mRNA expression of several antiviral immunity-related genes in grass carp after infection with genotype II grass carp reovirus.
  • Minglin Wu
  • Haiyang Li
  • Xiaowu Chen
  • Yangyang Jiang
  • Wei Jiang
  • Arch. Virol..2020 Jul;165(7):1599-1609. 10.1007/s00705-020-04654-y. doi: 10.1007/s00705-020-04654-y.Epub 2020-05-12.

早漏、その診断とフォルタシンスプレーによる局所治療に対する認識、期待、嗜好、態度。専門家パネルディスカッションの結果

Perceptions, Expectations, Preferences, and Attitudes Toward Premature Ejaculation, Its Diagnosis and Topical Treatment with Fortacin™ Spray: Results from an Expert Panel Discussion.
  • Ferdinando Fusco
  • Massimiliano Creta
  • Francesco Mangiapia
  • Lorenzo Cirigliano
  • Francesco Trama
  • Savio Domenico Pandolfo
  • Ciro Imbimbo
  • Nicola Longo
  • Vincenzo Mirone
  • Res Rep Urol.2020;12:211-216. 250301. doi: 10.2147/RRU.S250301.Epub 2020-07-02.

制御されたドキソルビシン送達のための磁気共鳴活性化可能な熱感受性リポソーム

Magnetic resonance activatable thermosensitive liposomes for controlled doxorubicin delivery.
  • Mohamad Alawak
  • Gihan Mahmoud
  • Alice Abu Dayyih
  • Lili Duse
  • Shashank Reddy Pinnapireddy
  • Konrad Engelhardt
  • Ibrahim Awak
  • Christian Wölk
  • Alexander M König
  • Jana Brüßler
  • Udo Bakowsky
  • Mater Sci Eng C Mater Biol Appl.2020 Oct;115:111116. S0928-4931(20)30616-0. doi: 10.1016/j.msec.2020.111116.Epub 2020-05-25.

オーストラリア、ビクトリア州の公立病院における難民背景を持つ女性のための妊産婦ケアへのアクセスを改善するためのシステム改革の評価。中断された時系列のデザイン

Evaluation of systems reform in public hospitals, Victoria, Australia, to improve access to antenatal care for women of refugee background: An interrupted time series design.
  • Jane Yelland
  • Fiona Mensah
  • Elisha Riggs
  • Ellie McDonald
  • Josef Szwarc
  • Wendy Dawson
  • Dannielle Vanpraag
  • Sue Casey
  • Christine East
  • Mary Anne Biro
  • Glyn Teale
  • Sue Willey
  • Stephanie J Brown
  • PLoS Med..2020 Jul;17(7):e1003089. PMEDICINE-D-19-03494. doi: 10.1371/journal.pmed.1003089.Epub 2020-07-10.

脳性麻痺患者の下肢痙縮の治療におけるボツリヌス毒素A型注射と比較した放射状体外衝撃波治療の有効性。無作為化対照クロスオーバー試験

Efficacy of radial extracorporeal shock wave therapy compared with botulinum toxin type A injection in treatment of lower extremity spasticity in subjects with cerebral palsy: A randomized, controlled, cross-over study.
  • Xavier Vidal
  • Joan Martí-Fàbregas
  • Olga Canet
  • Marta Roqué
  • Antoni Morral
  • Miriam Tur
  • Christoph Schmitz
  • Mercè Sitjà-Rabert
  • J Rehabil Med.2020 Jun;52(6):jrm00076. doi: 10.2340/16501977-2703.Epub 2020-06-30.

脳内浸透型のPQR620 mTORとPQR530 PI3K/mTOR阻害剤はHDの細胞モデルにおけるハンチントン病レベルを低下させる

Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD.
  • Elisabeth Singer
  • Carolin Walter
  • Doriano Fabbro
  • Denise Rageot
  • Florent Beaufils
  • Matthias P Wymann
  • Nadine Rischert
  • Olaf Riess
  • Petra Hillmann
  • Huu Phuc Nguyen
  • Neuropharmacology.2020 01;162:107812. S0028-3908(19)30379-X. doi: 10.1016/j.neuropharm.2019.107812.Epub 2019-10-14.

ブラジルにおける非妊娠女性を対象とした活動性梅毒に対するセフィキシムの臨床効果を評価する第 II 相試験(CeBra)

Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra).
  • Melanie M Taylor
  • Edna Oliveira Kara
  • Maria Alix Leite Araujo
  • Mariangela Freitas Silveira
  • Angelica Espinosa Miranda
  • Ivo Castelo Branco Coelho
  • Maria Luiza Bazzo
  • Gerson Fernando Mendes Pereira
  • Silvana Pereira Giozza
  • Ximena Pamela Díaz Bermudez
  • Maeve B Mello
  • Ndema Habib
  • My Huong Nguyen
  • Soe Soe Thwin
  • Nathalie Broutet
  • BMC Infect. Dis..2020 Jun;20(1):405. 10.1186/s12879-020-04980-1. doi: 10.1186/s12879-020-04980-1.Epub 2020-06-10.

T2および拡散強調MRIを用いた子宮頸癌における体積の描出。オブザーバー間の体積の一致

Volume Delineation in Cervical Cancer With T2 and Diffusion-weighted MRI: Agreement on Volumes Between Observers.
  • Consuelo Rosa
  • Andrea Delli Pizzi
  • Antonietta Augurio
  • Luciana Caravatta
  • Monica DI Tommaso
  • Erica Mincuzzi
  • Sebastiano Cinalli
  • Raffaella Basilico
  • Annamaria Porreca
  • Marta DI Nicola
  • Domenico Genovesi
  • In Vivo.2020 Jul-Aug;34(4):1981-1986. 34/4/1981. doi: 10.21873/invivo.11995.

再建手術を受けている乳がん患者に対するマッサージとマッサージプラス鍼治療との比較

Massage Compared with Massage Plus Acupuncture for Breast Cancer Patients Undergoing Reconstructive Surgery.
  • Christina A Dilaveri
  • Ivana T Croghan
  • Molly J Mallory
  • Liza J Dion
  • Karen M Fischer
  • Darrell R Schroeder
  • Jorys Martinez-Jorge
  • Minh-Doan T Nguyen
  • Shawn C Fokken
  • Brent A Bauer
  • Dietlind L Wahner-Roedler
  • J Altern Complement Med.2020 Jul;26(7):602-609. doi: 10.1089/acm.2019.0479.

アルツハイマー病における神経炎症メカニズムの精密医療への道

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease.
  • Harald Hampel
  • Filippo Caraci
  • A Claudio Cuello
  • Giuseppe Caruso
  • Robert Nisticò
  • Massimo Corbo
  • Filippo Baldacci
  • Nicola Toschi
  • Francesco Garaci
  • Patrizia A Chiesa
  • Steven R Verdooner
  • Leyla Akman-Anderson
  • Félix Hernández
  • Jesús Ávila
  • Enzo Emanuele
  • Pedro L Valenzuela
  • Alejandro Lucía
  • Mark Watling
  • Bruno P Imbimbo
  • Andrea Vergallo
  • Simone Lista
  • Front Immunol.2020;11:456. doi: 10.3389/fimmu.2020.00456.Epub 2020-03-31.

帯状疱疹と認知症との関連性と抗ウイルス療法の認知症リスクへの効果:集団ベースのコホート研究

Association of herpes zoster with dementia and effect of antiviral therapy on dementia: a population-based cohort study.
  • Seongman Bae
  • Sung-Cheol Yun
  • Min-Chul Kim
  • Woon Yoon
  • Joon Seo Lim
  • Sang-Oh Lee
  • Sang-Ho Choi
  • Yang Soo Kim
  • Jun Hee Woo
  • Seong Yoon Kim
  • Sung-Han Kim
  • Eur Arch Psychiatry Clin Neurosci.2020 Jul;10.1007/s00406-020-01157-4. doi: 10.1007/s00406-020-01157-4.Epub 2020-07-01.

再治療の長期フォローアップとアウトカム転移性去勢抵抗性前立腺癌におけるルテチウム-177(Lu)PSMA-617療法の拡張50患者単施設第II相前向き試験における再治療の長期フォローアップとアウトカム

Re: Long Term Follow-Up and Outcomes of Re-Treatment in an Expanded 50 Patient Single-Center Phase II Prospective Trial of Lutetium-177 (Lu) PSMA-617 Theranostics in Metastatic Castrate-Resistant Prostate Cancer.
  • Samir S Taneja
  • J. Urol..2020 05;203(5):882. doi: 10.1097/JU.0000000000000779.01.Epub 2020-02-13.

ホルモン受容体陽性/HER2陰性の早期乳癌患者における、免疫組織化学的に定義された腔状サブタイプに応じた用量密度の高い補助化学療法の効果:GIM2試験の探索的解析

Effect of dose-dense adjuvant chemotherapy in hormone receptor positive/HER2-negative early breast cancer patients according to immunohistochemically defined luminal subtype: an exploratory analysis of the GIM2 trial.
  • Benedetta Conte
  • Marco Bruzzone
  • Matteo Lambertini
  • Francesca Poggio
  • Claudia Bighin
  • Eva Blondeaux
  • Michelino De Laurentiis
  • Enrichetta Valle
  • Francesco Cognetti
  • Cecilia Nisticò
  • Sabino De Placido
  • Ornella Garrone
  • Teresa Gamucci
  • Filippo Montemurro
  • Fabio Puglisi
  • Barbara Cardinali
  • Piero Fregatti
  • Loredana Miglietta
  • Francesco Boccardo
  • Marcello Ceppi
  • Lucia Del Mastro
  • Eur. J. Cancer.2020 Jul;136:43-51. S0959-8049(20)30273-2. doi: 10.1016/j.ejca.2020.05.007.Epub 2020-07-04.

高齢マウスにアジュバント組換えインフルエンザ核タンパク質をワクチン接種すると,防御免疫が増強される.

Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity.
  • Tres Cookenham
  • Kathleen G Lanzer
  • Emily Gage
  • Erica C Lorenzo
  • Darrick Carter
  • Rhea N Coler
  • Susan L Baldwin
  • Laura Haynes
  • William W Reiley
  • Marcia A Blackman
  • Vaccine.2020 Jul;38(33):5256-5267. S0264-410X(20)30752-0. doi: 10.1016/j.vaccine.2020.05.085.Epub 2020-06-12.

小児小脳悪性腫瘍の治療を目的とした抗がん剤HSV G207のヒト初の第1相免疫療法臨床試験のデザインと根拠

Design and Rationale for First-In-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors.
  • Joshua D Bernstock
  • Asim Bag
  • John Fiveash
  • Kara Kachurak
  • Galal Elsayed
  • Gustavo Chagoya
  • Florian Gessler
  • Pablo A Valdes
  • Avi Madan-Swain
  • Richard Whitley
  • James Markert
  • Yancey Gillespie
  • James M Johnston
  • Gregory K Friedman
  • Hum. Gene Ther..2020 Jul;doi: 10.1089/hum.2020.101.Epub 2020-07-12.

マンソン病の免疫調節分子Sm16/SPO-1/SmSLPは、トレマトード特異的な蠕虫防御分子(HDM)の一種です

Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs).
  • Jenna Shiels
  • Krystyna Cwiklinski
  • Raquel Alvarado
  • Karine Thivierge
  • Sophie Cotton
  • Bibiana Gonzales Santana
  • Joyce To
  • Sheila Donnelly
  • Clifford C Taggart
  • Sinead Weldon
  • John P Dalton
  • PLoS Negl Trop Dis.2020 Jul;14(7):e0008470. PNTD-D-20-00627. doi: 10.1371/journal.pntd.0008470.Epub 2020-07-09.

DL-3-n-ブチルフタル酸は,大脳動脈硬化性狭窄症患者における脳血流低下を改善する:単施設,無作為化,二重盲検,プラセボ対照試験

DL-3-n-butylphthalide improves cerebral hypoperfusion in patients with large cerebral atherosclerotic stenosis: a single-center, randomized, double-blind, placebo-controlled study.
  • Dawei Chen
  • Yanwei Yin
  • Jin Shi
  • Fen Yang
  • Kehua Wang
  • Faguo Zhao
  • Wenping Li
  • Bin Li
  • BMC Neurol.2020 May;20(1):212. 10.1186/s12883-020-01801-5. doi: 10.1186/s12883-020-01801-5.Epub 2020-05-26.

思春期の若者におけるうつ病とモバイルテクノロジーやソーシャルメディアの利用との関係:アンブレラレビュー

Relationship between depression and the use of mobile technologies and social media among adolescents: an umbrella review.
  • Jorge Arias-de la Torre
  • Elisa Puigdomenech
  • Xavier Garcia
  • Jose M Valderas
  • Francisco Jose Eiroa-Orosa
  • Tania Fernandez-Villa
  • Antonio J Molina
  • Vicente Martin
  • Antoni Serrano-Blanco
  • Jordi Alonso
  • Mireia Espallargues
  • J. Med. Internet Res..2020 Jun;doi: 10.2196/16388.Epub 2020-06-03.

雌のアフリカ産コメ癭蝿(Orseolia oryzivora Harris and Gagné)の電気生理学的・行動学的反応と宿主植物の揮発性物質に対する反応

Electrophysiological and behavioral responses of female African rice gall midge, Orseolia oryzivora Harris and Gagné, to host plant volatiles.
  • Emmanuel O Ogah
  • Lesley E Smart
  • Christine M Woodcock
  • John C Caulfield
  • Michael A Birkett
  • John A Pickett
  • Francis E Nwilene
  • Toby J Bruce
  • J. Chem. Ecol..2017 Jan;43(1):13-16. 10.1007/s10886-016-0788-6. doi: 10.1007/s10886-016-0788-6.Epub 2016-11-04.

声帯瘢痕および声帯溝に対する組換え肝細胞増殖因子を用いた耳内注射の第I/II相探索的臨床試験

A phase I/II exploratory clinical trial for intracordal injection of recombinant hepatocyte growth factor for vocal fold scar and sulcus.
  • Shigeru Hirano
  • Atsuhiko Kawamoto
  • Ichiro Tateya
  • Masanobu Mizuta
  • Yo Kishimoto
  • Nao Hiwatashi
  • Yoshitaka Kawai
  • Takuya Tsuji
  • Ryo Suzuki
  • Mami Kaneko
  • Yasushi Naito
  • Tatsuo Kagimura
  • Tatsuo Nakamura
  • Shin-Ichi Kanemaru
  • J Tissue Eng Regen Med.2018 04;12(4):1031-1038. doi: 10.1002/term.2603.Epub 2017-12-25.

ボトリosphaeranは、Walker-256 腫瘍担持肥満ラットにおける腫瘍の発生と癌性悪液質症候群を減衰させ、これらのラットの代謝学的および血液学的プロフィールを改善する

Botryosphaeran Attenuates Tumor Development and the Cancer Cachexia Syndrome in Walker-256 Tumor-Bearing Obese Rats and Improves the Metabolic and Hematological Profiles of These Rats.
  • Patrícia K Comiran
  • Mariana C Ribeiro
  • John H G Silva
  • Kamila O Martins
  • Izabella A Santos
  • Ana Emilia F Chiaradia
  • Amadeu Z Silva
  • Robert F H Dekker
  • Aneli M Barbosa-Dekker
  • Pâmela Alegranci
  • Eveline A I F Queiroz
  • Nutr Cancer.2020 Jul;:1-18. doi: 10.1080/01635581.2020.1789681.Epub 2020-07-08.

TRPV4はミトコンドリアの輸送を阻害し、CaMKIIに依存した細胞内Caの上昇を介して軸索変性を引き起こす

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca.
  • Brian M Woolums
  • Brett A McCray
  • Hyun Sung
  • Masashi Tabuchi
  • Jeremy M Sullivan
  • Kendra Takle Ruppell
  • Yunpeng Yang
  • Catherine Mamah
  • William H Aisenberg
  • Pamela C Saavedra-Rivera
  • Bryan S Larin
  • Alexander R Lau
  • Douglas N Robinson
  • Yang Xiang
  • Mark N Wu
  • Charlotte J Sumner
  • Thomas E Lloyd
  • Nat Commun.2020 May;11(1):2679. 10.1038/s41467-020-16411-5. doi: 10.1038/s41467-020-16411-5.Epub 2020-05-29.

CD74アイソフォームが41kDaに存在しないことで、ヒト肺腺癌由来細胞におけるCD74とCD44の異型関連が抑制される

Absence of CD74 Isoform at 41kDa Prevents the Heterotypic Associations between CD74 and CD44 in Human Lung Adenocarcinoma-derived Cells.
  • Waleed Al Abdulmonem
  • Zafar Rasheed
  • Abdullah S M Aljohani
  • Ola M Omran
  • Naila Rasheed
  • Abdullah Alkhamiss
  • Abdulaziz A M Al Salloom
  • Fahad Alhumaydhi
  • Mohamd A Alblihed
  • Hussain Al Ssadh
  • Muhammad Ismail Khan
  • Nelson Fernández
  • Immunol. Invest..2020 Jul;:1-15. doi: 10.1080/08820139.2020.1790594.Epub 2020-07-09.

潰瘍性大腸炎患者の実世界コホートにおけるトファシチニブの安全性

Safety of Tofacitinib in a Real-World Cohort of Patients With Ulcerative Colitis.
  • Parakkal Deepak
  • Quazim A Alayo
  • Aava Khatiwada
  • Bixuan Lin
  • Marc Fenster
  • Christina Dimopoulos
  • Geoffrey Bader
  • Roni Weisshof
  • Michael Jacobs
  • Alexandra Gutierrez
  • Matthew A Ciorba
  • George P Christophi
  • Anish Patel
  • Robert P Hirten
  • Jean-Frederic Colombel
  • David T Rubin
  • Christina Ha
  • Poonam Beniwal-Patel
  • Ryan C Ungaro
  • Gaurav Syal
  • Joel Pekow
  • Benjamin L Cohen
  • Andres Yarur
  • Clin. Gastroenterol. Hepatol..2020 Jul;S1542-3565(20)30913-7. doi: 10.1016/j.cgh.2020.06.050.Epub 2020-07-03.

金属汚染環境下で増殖した海洋神経毒性渦鞭毛藻Alexandrium pacificumの膜プロテオーム、細胞増殖、形態測定における異種間の変動性

Intraspecific variability in membrane proteome, cell growth, and morphometry of the invasive marine neurotoxic dinoflagellate Alexandrium pacificum grown in metal-contaminated conditions.
  • Cherif Chetouhi
  • Estelle Masseret
  • Cecilia Teodora Satta
  • Thierry Balliau
  • Mohamed Laabir
  • Natacha Jean
  • Sci. Total Environ..2020 May;715:136834. S0048-9697(20)30344-2. doi: 10.1016/j.scitotenv.2020.136834.Epub 2020-01-25.

大豆タンパク質単離物フィブリルと赤ビートルーツ由来のベタレインとの相互作用。大豆タンパク質単離物フィブリルとベタレインの相互作用:形態学、分光学的特性および熱安定性

Interaction of soy protein isolate fibrils with betalain from red beetroots: Morphology, spectroscopic characteristics and thermal stability.
  • Hui-Shuang Zhao
  • Zhen Ma
  • Pu Jing
  • Food Res. Int..2020 Sep;135:109289. S0963-9969(20)30314-8. doi: 10.1016/j.foodres.2020.109289.Epub 2020-05-05.

COVID-19で入院した最初の63人の成人患者の臨床的特徴と転帰。オマーンでの経験

Clinical characteristics and outcomes of the first 63 adult patients hospitalized with COVID-19: An experience from Oman.
  • Faryal Khamis
  • Ibrahim Al-Zakwani
  • Hamed Al Naamani
  • Sultan Al Lawati
  • Nenad Pandak
  • Muna Ba Omar
  • Maher Al Bahrani
  • Zakaryia Al Bulushi
  • Huda Al Khalili
  • Issa Al Salmi
  • Ruwaida Al Ismaili
  • Salah T Al Awaidy
  • J Infect Public Health.2020 Jul;13(7):906-913. S1876-0341(20)30496-2. doi: 10.1016/j.jiph.2020.06.002.Epub 2020-06-08.

原発性腋窩多汗症患者を対象としたUmeclidiniumの外用薬の薬物動態、安全性、忍容性および臨床効果を評価するための第2a相無作為化比較試験

A phase 2a randomized controlled study to evaluate the pharmacokinetic, safety, tolerability and clinical effect of topically applied Umeclidinium in subjects with primary axillary hyperhidrosis.
  • A Nasir
  • R Bissonnette
  • C Maari
  • J DuBois
  • T Pene Dumitrescu
  • J Haddad
  • Y Yamaguchi
  • M Dalessandro
  • J Eur Acad Dermatol Venereol.2018 Jan;32(1):145-151. doi: 10.1111/jdv.14651.Epub 2017-11-07.

CANVASプログラムにおけるカナグリフロジンとグルカゴン様ペプチド-1受容体アゴニストの併用療法の心血管リスクの中間マーカーに対する効果

The effects of combination canagliflozin and glucagon-like peptide-1 receptor agonist therapy on intermediate markers of cardiovascular risk in the CANVAS program.
  • Clare Arnott
  • Brendon L Neuen
  • Hiddo J L Heerspink
  • Gemma A Figtree
  • Mikhail Kosiborod
  • Carolyn S Lam
  • Christopher P Cannon
  • Norman Rosenthal
  • Wayne Shaw
  • Kenneth W Mahaffey
  • Meg J Jardine
  • Vlado Perkovic
  • Bruce Neal
  • Int. J. Cardiol..2020 Jun;S0167-5273(20)33389-1. doi: 10.1016/j.ijcard.2020.06.011.Epub 2020-06-20.

養子縁組前の逆境にある子どもの注意欠陥のリスクを調節する。家庭外プレースメントと子どもの強化されたエラーモニタリングのより短い期間の保護的役割

Moderating the Risk for Attention Deficits in Children with Pre-Adoptive Adversity: The Protective Role of Shorter Duration of out of Home Placement and Children's Enhanced Error Monitoring.
  • Tahl I Frenkel
  • Bonny Donzella
  • Kristin A Frenn
  • Sofie Rousseau
  • Nathan A Fox
  • Megan R Gunnar
  • J Abnorm Child Psychol.2020 Jun;10.1007/s10802-020-00671-2. doi: 10.1007/s10802-020-00671-2.Epub 2020-06-30.

Cycloarta-23-ene-3beta,25-diolはEuphorbia spinidens由来の五環ステロイドであり、分子ドッキングによるCOX阻害剤として、スイスの雄性マウスとWistarラットにおける鎮痛・抗炎症活性のin vivoでの研究を行った

Cycloarta-23-ene-3beta,25-diol a pentacyclic steroid from Euphorbia spinidens, as COX inhibitor with molecular docking, and in vivo study of its analgesic and anti-inflammatory activities in male Swiss mice and Wistar rats.
  • Valiollah Hajhashemi
  • Mustafa Ghanadian
  • Abbasali Palizaban
  • Karim Mahnam
  • Hamed Eshaghi
  • Bahareh Gheisari
  • Hojjat Sadeghi-Aliabadi
  • Prostaglandins Other Lipid Mediat..2020 Jul;:106473. S1098-8823(20)30066-6. doi: 10.1016/j.prostaglandins.2020.106473.Epub 2020-07-04.

公的ADL尺度を用いた入院患者の転倒予測モデルの開発:急性期医療における7,858人の患者を対象としたレトロスペクティブ観察研究

New predictive models for falls among inpatients using public ADL scale in Japan: A retrospective observational study of 7,858 patients in acute care setting.
  • Masaki Tago
  • Naoko E Katsuki
  • Yoshimasa Oda
  • Eiji Nakatani
  • Takashi Sugioka
  • Shu-Ichi Yamashita
  • PLoS ONE.2020;15(7):e0236130. PONE-D-20-14794. doi: 10.1371/journal.pone.0236130.Epub 2020-07-16.

バナナMaSPL16はリコピンβ-サイクラーゼ遺伝子の転写を活性化することで、果実の成熟期におけるカロテノイド生合成を調節する

Banana MaSPL16 Modulates Carotenoid Biosynthesis during Fruit Ripening through Activating the Transcription of Lycopene β-Cyclase Genes.
  • Li-Sha Zhu
  • Shu-Min Liang
  • Lu-Lu Chen
  • Chao-Jie Wu
  • Wei Wei
  • Wei Shan
  • Jian-Ye Chen
  • Wang-Jin Lu
  • Xin-Guo Su
  • Jian-Fei Kuang
  • J. Agric. Food Chem..2020 Feb;68(5):1286-1296. doi: 10.1021/acs.jafc.9b07134.Epub 2020-01-24.

糖尿病は不顕性頸動脈動脈硬化症と独立して関連している。非都市型地中海人集団における観察研究

Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population.
  • Maria Belén Vilanova
  • Josep Franch-Nadal
  • Mireia Falguera
  • Josep Ramon Marsal
  • Sílvia Canivell
  • Esther Rubinat
  • Neus Miró
  • Àngels Molló
  • Manel Mata-Cases
  • Mònica Gratacòs
  • Esmeralda Castelblanco
  • Dídac Mauricio
  • J Clin Med.2020 Jul;9(7). E2139. doi: 10.3390/jcm9072139.Epub 2020-07-07.

PD-L2/B7-DCの小型干渉RNAの局所適用によるサイレンシングは、接触過敏症の誘発を抑制する

Silencing of PD-L2/B7-DC by Topical Application of Small Interfering RNA Inhibits Elicitation of Contact Hypersensitivity.
  • Emi Furusawa
  • Tatsukuni Ohno
  • Shigenori Nagai
  • Taisei Noda
  • Takuya Komiyama
  • Katsunori Kobayashi
  • Hidetoshi Hamamoto
  • Michiyo Miyashin
  • Hiroo Yokozeki
  • Miyuki Azuma
  • J. Invest. Dermatol..2019 10;139(10):2164-2173.e1. S0022-202X(19)31474-5. doi: 10.1016/j.jid.2019.02.037.Epub 2019-04-09.

DRP1を介したミトコンドリアの分裂とマイトファジーの抑制は、低酸素環境下での肝細胞癌細胞のミトコンドリアのアポトーシスを増加させる

Suppressing DRP1-mediated mitochondrial fission and mitophagy increases mitochondrial apoptosis of hepatocellular carcinoma cells in the setting of hypoxia.
  • Xia-Hui Lin
  • Bai-Quan Qiu
  • Min Ma
  • Rui Zhang
  • Shu-Jung Hsu
  • Hua-Hua Liu
  • Jun Chen
  • Dong-Mei Gao
  • Jie-Feng Cui
  • Zheng-Gang Ren
  • Rong-Xin Chen
  • Oncogenesis.2020 Jul;9(7):67. 10.1038/s41389-020-00251-5. doi: 10.1038/s41389-020-00251-5.Epub 2020-07-13.

英国におけるSARS-CoV-2(PIMS-TS)と一時的に関連した小児炎症性多系統症候群の小児の集中治療入院:多施設観察研究

Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study.
  • Patrick Davies
  • Claire Evans
  • Hari Krishnan Kanthimathinathan
  • Jon Lillie
  • Joseph Brierley
  • Gareth Waters
  • Mae Johnson
  • Benedict Griffiths
  • Pascale du Pré
  • Zoha Mohammad
  • Akash Deep
  • Stephen Playfor
  • Davinder Singh
  • David Inwald
  • Michelle Jardine
  • Oliver Ross
  • Nayan Shetty
  • Mark Worrall
  • Ruchi Sinha
  • Ashwani Koul
  • Elizabeth Whittaker
  • Harish Vyas
  • Barnaby R Scholefield
  • Padmanabhan Ramnarayan
  • Lancet Child Adolesc Health.2020 Jul;S2352-4642(20)30215-7. doi: 10.1016/S2352-4642(20)30215-7.Epub 2020-07-09.

エキスポネンシャルエンリッチメントによるリガンドの細胞系進化を利用した血症に対するDNAアプタマーの開発

Development of DNA Aptamers Against Blood Stages Using Cell-Systematic Evolution of Ligands by EXponential Enrichment.
  • Elena Lantero
  • Alexandros Belavilas-Trovas
  • Arnau Biosca
  • Paula Recolons
  • Ernest Moles
  • Elena Sulleiro
  • Francesc Zarzuela
  • Yunuen Ávalos-Padilla
  • Miriam Ramírez
  • Xavier Fernàndez-Busquets
  • J Biomed Nanotechnol.2020 Mar;16(3):315-334. doi: 10.1166/jbn.2020.2901.

南西インディアン・リッジ東部の深海堆積物から分離された海洋性多糖類産生菌アルテロモナス・ペラギモンタナ5.12の全ゲノム配列

Complete genome sequence of Alteromonas pelagimontana 5.12, a marine exopolysaccharide-producing bacterium isolated from hydrothermally influenced deep-sea sediment of eastern Southwest Indian Ridge.
  • Rupesh Kumar Sinha
  • K P Krishnan
  • P John Kurian
  • Mar Genomics.2020 Jul;:100804. S1874-7787(20)30065-9. doi: 10.1016/j.margen.2020.100804.Epub 2020-07-11.

適応的実験室進化により選抜されたKluyveromyces marxianus CCT 7735のエタノール耐性の評価

Assessment of ethanol tolerance of Kluyveromyces marxianus CCT 7735 selected by adaptive laboratory evolution.
  • Fernando Augusto da Silveira
  • Dalila Luzia de Oliveira Soares
  • Kyung Whan Bang
  • Thércia Rocha Balbino
  • Maurício Alexander de Moura Ferreira
  • Raphael Hermano Santos Diniz
  • Lorena Azevedo de Lima
  • Marcelo Mendes Brandão
  • Silas Granato Villas-Bôas
  • Wendel Batista da Silveira
  • Appl. Microbiol. Biotechnol..2020 Jul;10.1007/s00253-020-10768-9. doi: 10.1007/s00253-020-10768-9.Epub 2020-07-16.

COVID-19関連血栓症を二次性抗リン脂質抗体症候群に巻き込む。診断と治療の視点(レビュー)

Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review).
  • Eugenio Cavalli
  • Alessia Bramanti
  • Rosella Ciurleo
  • Andrey I Tchorbanov
  • Antonio Giordano
  • Paolo Fagone
  • Cristina Belizna
  • Placido Bramanti
  • Yehuda Shoenfeld
  • Ferdinando Nicoletti
  • Int. J. Mol. Med..2020 Jun;doi: 10.3892/ijmm.2020.4659.Epub 2020-06-25.

肝虚血再灌流(I/R)傷害に対するジンセノサイドRg1の効果は、アポトーシスを阻害することにより、虚血再灌流誘発性肝障害を改善する

The effect of Ginsenoside Rg1 in hepatic ischemia reperfusion (I/R) injury ameliorates ischemia-reperfusion-induced liver injury by inhibiting apoptosis.
  • Jie Lin
  • Han-Fei Huang
  • Shi-Kun Yang
  • Jian Duan
  • Si-Ming Qu
  • Bo Yuan
  • Zhong Zeng
  • Biomed. Pharmacother..2020 Jun;129:110398. S0753-3322(20)30591-6. doi: 10.1016/j.biopha.2020.110398.Epub 2020-06-27.

セルロース分解性クロストリジアのペントースリン酸経路は、トランスアルドラーゼの代わりに6-ホスホフルクトキナーゼに依存している

The pentose phosphate pathway of cellulolytic clostridia relies on 6-phosphofructokinase instead of transaldolase.
  • Jeroen G Koendjbiharie
  • Shuen Hon
  • Martin Pabst
  • Robert Hooftman
  • David M Stevenson
  • Jingxuan Cui
  • Daniel Amador-Noguez
  • Lee R Lynd
  • Daniel G Olson
  • Richard van Kranenburg
  • J. Biol. Chem..2020 Feb;295(7):1867-1878. RA119.011239. doi: 10.1074/jbc.RA119.011239.Epub 2019-12-22.

患者の診察中に医療従事者が使用するコミュニケーション技術と補助具の分類法を開発する。システマティックレビューのためのプロトコル

Developing a Taxonomy of Communication Techniques and Aids Used By Healthcare Providers During Patient Consultations: Protocol for a Systematic Review.
  • Violetta Shersher
  • Terry P Haines
  • Cylie Williams
  • Louisa Willoughby
  • Elizabeth Sturgiss
  • Carolina Weller
  • JMIR Res Protoc.2020 Jul;9(7):e16801. v9i7e16801. doi: 10.2196/16801.Epub 2020-07-14.

メトトレキサート誘発性腎毒性に対するベルベリンの保護効果における Keap1/Nrf2、PMAPK/NF-κB および Bax/Bcl2/caspase-3 シグナル伝達経路の影響

The impact of Keap1/Nrf2, PMAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity.
  • Emad H M Hassanein
  • Abdel-Gawad S Shalkami
  • Marwa M Khalaf
  • Wafaa R Mohamed
  • Ramadan A M Hemeida
  • Biomed. Pharmacother..2019 Jan;109:47-56. S0753-3322(18)37048-3. doi: 10.1016/j.biopha.2018.10.088.Epub 2018-11-02.

注意欠陥/多動性障害の有無にかかわらず、治療を求める物質使用障害患者における初期の破壊的行動障害の発症と重症度

Onset and Severity of Early Disruptive Behavioral Disorders in Treatment-Seeking Substance Use Disorder Patients with and without Attention-Deficit/Hyperactivity Disorder.
  • Rafael A González
  • María C Vélez-Pastrana
  • Matthijs Blankers
  • Amanda Bäcker
  • Maija Konstenius
  • Martin Holtmann
  • Frances R Levin
  • Moritz Noack
  • Sharlene Kaye
  • Zsolt Demetrovics
  • Geurt van de Glind
  • Wim van den Brink
  • Arnt Schellekens
  • Eur Addict Res.2020 06;:1-12. 000508653. doi: 10.1159/000508653.Epub 2020-06-26.