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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

リン酸化プロテオーム解析により、CLK1 が胃癌の新規治療標的であることが明らかになった

Phosphoproteomic analysis identifies CLK1 as a novel therapeutic target in gastric cancer.
  • Niraj Babu
  • Sneha M Pinto
  • Manjusha Biswas
  • Tejaswini Subbannayya
  • Manoj Rajappa
  • Sonali V Mohan
  • Jayshree Advani
  • Pavithra Rajagopalan
  • Gajanan Sathe
  • Nazia Syed
  • Vinod D Radhakrishna
  • Oliyarasi Muthusamy
  • Sanjay Navani
  • Rekha V Kumar
  • Gopal Gopisetty
  • Thangarajan Rajkumar
  • Padhma Radhakrishnan
  • Saravanan Thiyagarajan
  • Akhilesh Pandey
  • Harsha Gowda
  • Pradip Majumder
  • Aditi Chatterjee
  • Gastric Cancer.2020 Apr;10.1007/s10120-020-01062-8. doi: 10.1007/s10120-020-01062-8.Epub 2020-04-24.

気管支肺胞液中の単純ヘルペスウイルス 1 型患者の機械換気患者の転帰に及ぼす抗ウイルス療法の効果:レトロスペクティブコホート研究

Effect of antiviral therapy on the outcome of mechanically ventilated patients with herpes simplex virus type 1 in bronchoalveolar lavage fluid: a retrospective cohort study.
  • Elisabeth Heimes
  • Michael Baier
  • Christina Forstner
  • Sebastian Weis
  • Michael Bauer
  • Michael Fritzenwanger
  • André Scherag
  • Mathias W Pletz
  • Miriam Kesselmeier
  • Stefan Hagel
  • Chest.2020 Jul;S0012-3692(20)31854-7. doi: 10.1016/j.chest.2020.06.056.Epub 2020-07-03.

チモロールマレイン酸塩を担持した第四級キトサン系感熱性ハイドロゲルの合成と特性:緑内障治療のための透明な外用眼球送達システム

Synthesis and characterization of timolol maleate-loaded quaternized chitosan-based thermosensitive hydrogel: A transparent topical ocular delivery system for the treatment of glaucoma.
  • Yousef Pakzad
  • Marziyeh Fathi
  • Yadollah Omidi
  • Masoud Mozafari
  • Ali Zamanian
  • Int. J. Biol. Macromol..2020 May;159:117-128. S0141-8130(20)33145-7. doi: 10.1016/j.ijbiomac.2020.04.274.Epub 2020-05-05.

DUODENAL-JEJUNAL BYPASSが視床下部肥満ラットの褐色付着部における脂質蓄積を減少させることを明らかにした

DUODENAL-JEJUNAL BYPASS REDUCES LIPID ACCUMULATION IN THE BROWN ADIPOSE TISSUE OF HYPOTHALAMIC OBESE RATS.
  • Vanessa Marieli Ceglarek
  • Zoé Maria Guareschi
  • Gabriela Moreira-Soares
  • Rafaela Cristiane Ecker-Passarello
  • Sandra Lucinei Balbo
  • Maria Lúcia Bonfleur
  • Sabrina Grassiolli
  • Arq Bras Cir Dig.2020 Jul;33(1):e1497. S0102-67202020000100307. doi: 10.1590/0102-672020190001e1497.

α-シヌクレイン神経毒性のリピドミクス解析によりステアロイルCoAデサチュラーゼをパーキンソン治療の標的として同定

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
  • Saranna Fanning
  • Aftabul Haque
  • Thibaut Imberdis
  • Valeriya Baru
  • M Inmaculada Barrasa
  • Silke Nuber
  • Daniel Termine
  • Nagendran Ramalingam
  • Gary P H Ho
  • Tallie Noble
  • Jackson Sandoe
  • Yali Lou
  • Dirk Landgraf
  • Yelena Freyzon
  • Gregory Newby
  • Frank Soldner
  • Elizabeth Terry-Kantor
  • Tae-Eun Kim
  • Harald F Hofbauer
  • Michel Becuwe
  • Rudolf Jaenisch
  • David Pincus
  • Clary B Clish
  • Tobias C Walther
  • Robert V Farese
  • Supriya Srinivasan
  • Michael A Welte
  • Sepp D Kohlwein
  • Ulf Dettmer
  • Susan Lindquist
  • Dennis Selkoe
  • Mol. Cell.2019 03;73(5):1001-1014.e8. S1097-2765(18)30998-5. doi: 10.1016/j.molcel.2018.11.028.Epub 2018-12-04.

完全磁気浮上式の小型遠心式左室補助装置の脈動運転下での血行動態性能。脈動運転下での完全磁気浮上式小型遠心式左室補助装置の血行動態性能:in vitro試験

Hemodynamic performance of a compact centrifugal left ventricular assist device with fully magnetic levitation under pulsatile operation: An in vitro study.
  • Tingting Wu
  • Hao Lin
  • Yuxin Zhu
  • Penghui Huang
  • Frank Lin
  • Chen Chen
  • Po-Lin Hsu
  • Proc Inst Mech Eng H.2020 Jul;:954411920937919. doi: 10.1177/0954411920937919.Epub 2020-07-10.

均一な粒子径とユニークな輸送タンパク質関連タンパク質コロナを持つFe/Mg修飾炭酸アパタイトは、乳がん細胞にドキソルビシンを効率的に送達する

Fe/Mg-Modified Carbonate Apatite with Uniform Particle Size and Unique Transport Protein-Related Protein Corona Efficiently Delivers Doxorubicin into Breast Cancer Cells.
  • Sheikh Tanzina Haque
  • Md Emranul Karim
  • Syafiq Asnawi Zainal Abidin
  • Iekhsan Othman
  • Mark M Banaszak Holl
  • Ezharul Hoque Chowdhury
  • Nanomaterials (Basel).2020 Apr;10(5). E834. doi: 10.3390/nano10050834.Epub 2020-04-27.

間葉系幹細胞由来の生体適合性膜ベシクルは、ヒト単核球の活性化と増殖を抑制する免疫調節活性を示す

Mesenchymal Stem Cell Derived Biocompatible Membrane Vesicles Demonstrate Immunomodulatory Activity Inhibiting Activation and proliferation of Human Mononuclear Cells.
  • Marina O Gomzikova
  • Sevindzh K Kletukhina
  • Sirina V Kurbangaleeva
  • Olga A Neustroeva
  • Olga S Vasileva
  • Ekaterina E Garanina
  • Svetlana F Khaiboullina
  • Albert A Rizvanov
  • Pharmaceutics.2020 Jun;12(6). E577. doi: 10.3390/pharmaceutics12060577.Epub 2020-06-23.

COVID-19患者に対する回復期血漿または高免疫性免疫グロブリン:生きたシステマティックレビュー

Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review.
  • Vanessa Piechotta
  • Khai Li Chai
  • Sarah J Valk
  • Carolyn Doree
  • Ina Monsef
  • Erica M Wood
  • Abigail Lamikanra
  • Catherine Kimber
  • Zoe McQuilten
  • Cynthia So-Osman
  • Lise J Estcourt
  • Nicole Skoetz
  • Cochrane Database Syst Rev.2020 07;7:CD013600. doi: 10.1002/14651858.CD013600.pub2.Epub 2020-07-10.

クルクミンによるGSK-3β阻害は、ヒト神経芽腫細胞において、TFEBの活性化と抗酸化活性を介してアミロイド生成を抑制します

GSK-3β inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative Activity in human neuroblastoma cells.
  • Hyun-Chul Song
  • Yubing Chen
  • Yingqing Chen
  • Jeongmin Park
  • Min Zheng
  • Young-Joon Surh
  • Uh-Hyun Kim
  • Jeong Woo Park
  • Rina Yu
  • Hun Taeg Chung
  • Yeonsoo Joe
  • Free Radic. Res..2020 Jul;:1-39. doi: 10.1080/10715762.2020.1791843.Epub 2020-07-06.

慢性HBV感染症患者におけるB型肝炎表面抗原のウイルス特異的およびグローバルT細胞に対する効果

Effects of Hepatitis B Surface Antigen on Virus-specific and Global T Cells in Patients With Chronic HBV infection.
  • Nina Le Bert
  • Upkar S Gill
  • Michelle Hong
  • Kamini Kunasegaran
  • Damien Z M Tan
  • Raidah Ahmad
  • Yang Cheng
  • Charles-A Dutertre
  • Andreas Heinecke
  • Laura Rivino
  • Anthony Tan
  • Navjyot K Hansi
  • Min Zhang
  • Sujuan Xi
  • Yutian Chong
  • Stefan Pflanz
  • Evan W Newell
  • Patrick T F Kennedy
  • Antonio Bertoletti
  • Gastroenterology.2020 Apr;S0016-5085(20)30492-3. doi: 10.1053/j.gastro.2020.04.019.Epub 2020-04-14.

非骨髄芽腫性β-サラサラ血症マウスにおけるβ-サラサラ血症患者由来の遺伝的に補正されたiPSCの安全性と有効性

The safety and effectiveness of genetically corrected iPSCs derived from β-thalassaemia patients in nonmyeloablative β-thalassaemic mice.
  • Yexing Xian
  • Yingjun Xie
  • Bing Song
  • Zhanhui Ou
  • Shuming Ouyang
  • Yuhuan Xie
  • Yi Yang
  • Zeyu Xiong
  • Haoxian Li
  • Xiaofang Sun
  • Stem Cell Res Ther.2020 Jul;11(1):288. 10.1186/s13287-020-01765-w. doi: 10.1186/s13287-020-01765-w.Epub 2020-07-16.

脳微小透析研究のためのバイオマトリックス中の物理化学的特性と未結合画分に基づく中枢神経系薬剤候補の除外

Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations.
  • Qianwen Wang
  • Tianjing Ren
  • Jiajia Zhao
  • Chun-Ho Wong
  • H Y Edwin Chan
  • Zhong Zuo
  • J Pharm Biomed Anal.2020 Jan;178:112946. S0731-7085(19)30281-X. doi: 10.1016/j.jpba.2019.112946.Epub 2019-10-25.

Brachiaria brizanthaへのEnterolobium cyclocarpumポッドおよびGliricidia sepium飼料の添加が乾物分解、揮発性脂肪酸濃度、およびin vitroメタン生産に及ぼす影響

Effect of the addition of Enterolobium cyclocarpum pods and Gliricidia sepium forage to Brachiaria brizantha on dry matter degradation, volatile fatty acid concentration, and in vitro methane production.
  • Isabel Cristina Molina-Botero
  • Johanna Mazabel
  • Jeyder Arceo-Castillo
  • José Luis Urrea-Benítez
  • Leticia Olivera-Castillo
  • Rolando Barahona-Rosales
  • Ngonidzashe Chirinda
  • Juan Ku-Vera
  • Jacobo Arango
  • Trop Anim Health Prod.2020 Jul;10.1007/s11250-020-02324-4. doi: 10.1007/s11250-020-02324-4.Epub 2020-07-09.

TOR1AIP1-associated nuclear envelopathiesの表現型をさらに拡大した2つの新規症例

Two novel cases further expand the phenotype of TOR1AIP1-associated nuclear envelopathies.
  • Ivana Lessel
  • Mei-Jan Chen
  • Sabine Lüttgen
  • Florian Arndt
  • Sigrid Fuchs
  • Stefanie Meien
  • Holger Thiele
  • Julie R Jones
  • Brandon R Shaw
  • David K Crossman
  • Peter Nürnberg
  • Bruce R Korf
  • Christian Kubisch
  • Davor Lessel
  • Hum. Genet..2020 Apr;139(4):483-498. 10.1007/s00439-019-02105-6. doi: 10.1007/s00439-019-02105-6.Epub 2020-02-13.

リトアニアの IPV ワクチン接種児を対象とした 1 価経口 2 型サビンポリオワクチン接種後の免疫原性と安全性に関する無作為化第 4 相試験

A randomized phase 4 study of immunogenicity and safety following monovalent oral type 2 Sabin polio vaccine challenge in IPV-vaccinated children in Lithuania.
  • Ananda S Bandyopadhyay
  • Chris Gast
  • Elizabeth B Brickley
  • Ricardo Rüttimann
  • Ralf Clemens
  • M Steven Oberste
  • William C Weldon
  • Margaret E Ackerman
  • Ruth I Connor
  • Wendy F Wieland-Alter
  • Peter Wright
  • Vytautas Usonis
  • J. Infect. Dis..2020 Jul;jiaa390. doi: 10.1093/infdis/jiaa390.Epub 2020-07-04.

根管形成における交渉、グライドパス、プレフレアの手順が根管形成に与える影響-用語、基本概念、および系統的なレビュー

Influence of Negotiation, Glide Path, and Preflaring Procedures on Root Canal Shaping-Terminology, Basic Concepts, and a Systematic Review.
  • Gianluca Plotino
  • Venkateshbabu Nagendrababu
  • Frederic Bukiet
  • Nicola M Grande
  • Sajesh K Veettil
  • Gustavo De-Deus
  • Hany Mohamed Aly Ahmed
  • J Endod.2020 Jun;46(6):707-729. S0099-2399(20)30076-5. doi: 10.1016/j.joen.2020.01.023.Epub 2020-04-22.

骨粗鬆症性椎体圧迫骨折(OVCF)患者の治療における片側と両側の経皮的弯曲術の比較:システマティックレビューとメタアナリシス

Comparison of unilateral versus bilateral percutaneous kyphoplasty for the treatment of patients with osteoporosis vertebral compression fracture (OVCF): a systematic review and meta-analysis.
  • Xing Cheng
  • Hou-Qing Long
  • Jing-Hui Xu
  • Yang-Liang Huang
  • Fo-Bao Li
  • Eur Spine J.2016 11;25(11):3439-3449. 10.1007/s00586-016-4395-6. doi: 10.1007/s00586-016-4395-6.Epub 2016-01-27.

5αリダクターゼ阻害剤の共投与は、処方されたグルココルチコイドの有害な代謝作用を悪化させる

Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids.
  • Nantia Othonos
  • Thomas Marjot
  • Conor Woods
  • Jonathan M Hazlehurst
  • Nikolaos Nikolaou
  • Riccardo Pofi
  • Sarah White
  • Ilaria Bonaventura
  • Craig Webster
  • Joanne Duffy
  • Thomas Cornfield
  • Ahmad Moolla
  • Andrea M Isidori
  • Leanne Hodson
  • Jeremy W Tomlinson
  • J. Clin. Endocrinol. Metab..2020 Jun;dgaa408. doi: 10.1210/clinem/dgaa408.Epub 2020-06-27.

ルネッサンスへの準備:COVID-19パンデミック時の乳がんの治療と、ユニバーサル・ヘルスケア・システム内での日常的な外科的ケアへの安全な再浮上のための計画

Preparing for the renaissance: treating breast cancer during the COVID-19 pandemic and planning for a safe re-emergence to routine surgical care within a universal health care system.
  • D Berger-Richardson
  • G Ko
  • N J Look Hong
  • Curr Oncol.2020 06;27(3):163-168. conc-27-163. doi: 10.3747/co.27.6699.Epub 2020-06-01.

ソニックヘッジホッグ/Gli経路転写標的であるNeogenin-1のダウンレギュレーションは、基底細胞癌の攻撃性と関連している

Downregulation of the Sonic Hedgehog/Gli pathway transcriptional target Neogenin-1 is associated with basal cell carcinoma aggressiveness.
  • Bárbara S Casas
  • Christelle Adolphe
  • Pablo Lois
  • Nelson Navarrete
  • Natalia Solís
  • Eva Bustamante
  • Patricio Gac
  • Patricio Cabané
  • Ivan Gallegos
  • Brandon J Wainwright
  • Verónica Palma
  • Oncotarget.2017 Oct;8(48):84006-84018. 21061. doi: 10.18632/oncotarget.21061.Epub 2017-09-19.

心筋虚血が疑われる安定した外来患者におけるフローサイトメトリーに基づく血小板反応性の性差

Sex differences in flow cytometry-based platelet reactivity in stable outpatients suspected of myocardial ischemia.
  • Farahnaz Waissi
  • Mirthe Dekker
  • Ingrid E M Bank
  • Suzanne J A Korporaal
  • Rolf T Urbanus
  • Gert J de Borst
  • Gerard Pasterkamp
  • Asbjorn M Scholtens
  • Diederick E Grobbee
  • Arend Mosterd
  • Dominique P V de Kleijn
  • Leo Timmers
  • Res Pract Thromb Haemost.2020 Jul;4(5):879-885. RTH212344. doi: 10.1002/rth2.12344.Epub 2020-05-15.

一般的なバイオマーカーから導き出された有効な死亡率リスクスコアを用いて、退院後に病院関連の静脈血栓塞栓症を医療患者の間で予測する

Predicting postdischarge hospital-associated venous thromboembolism among medical patients using a validated mortality risk score derived from common biomarkers.
  • Lindsey Snyder
  • Scott M Stevens
  • Masarret Fazili
  • Emily L Wilson
  • James F Lloyd
  • Benjamin D Horne
  • Joseph Bledsoe
  • Scott C Woller
  • Res Pract Thromb Haemost.2020 Jul;4(5):872-878. RTH212343. doi: 10.1002/rth2.12343.Epub 2020-05-20.

ヤギにおける家畜化遺伝子の起源

The origin of domestication genes in goats.
  • Zhuqing Zheng
  • Xihong Wang
  • Ming Li
  • Yunjia Li
  • Zhirui Yang
  • Xiaolong Wang
  • Xiangyu Pan
  • Mian Gong
  • Yu Zhang
  • Yingwei Guo
  • Yu Wang
  • Jing Liu
  • Yudong Cai
  • Qiuming Chen
  • Moses Okpeku
  • Licia Colli
  • Dawei Cai
  • Kun Wang
  • Shisheng Huang
  • Tad S Sonstegard
  • Ali Esmailizadeh
  • Wenguang Zhang
  • Tingting Zhang
  • Yangbin Xu
  • Naiyi Xu
  • Yi Yang
  • Jianlin Han
  • Lei Chen
  • Joséphine Lesur
  • Kevin G Daly
  • Daniel G Bradley
  • Rasmus Heller
  • Guojie Zhang
  • Wen Wang
  • Yulin Chen
  • Yu Jiang
  • Sci Adv.2020 May;6(21):eaaz5216. aaz5216. doi: 10.1126/sciadv.aaz5216.Epub 2020-05-20.

コネクトベースのモデルは大うつ病性障害の初期症状改善を予測できる

Connectome-based models can predict early symptom improvement in major depressive disorder.
  • Yumeng Ju
  • Corey Horien
  • Wentao Chen
  • Weilong Guo
  • Xiaowen Lu
  • Jinrong Sun
  • Qiangli Dong
  • Bangshan Liu
  • Jin Liu
  • Danfeng Yan
  • Mi Wang
  • Liang Zhang
  • Hua Guo
  • Futao Zhao
  • Yan Zhang
  • Xilin Shen
  • R Todd Constable
  • Lingjiang Li
  • J Affect Disord.2020 Aug;273:442-452. S0165-0327(20)30620-0. doi: 10.1016/j.jad.2020.04.028.Epub 2020-05-11.

抗ミューレリアンホルモンと卵胞数は、POSEIDON群3および4の患者における最初の完全卵巣刺激サイクルの累積治療成績を予測する能力に違いがある

Anti-Müllerian hormone and antral follicle count differ in their ability to predict cumulative treatment outcomes of the first complete ovarian stimulation cycle in patients from POSEIDON groups 3 and 4.
  • Luxin Liu
  • Canquan Zhou
  • J. Obstet. Gynaecol. Res..2020 Jul;doi: 10.1111/jog.14269.Epub 2020-07-19.

経皮的冠動脈インターベンションを受けた中国人急性冠症候群患者に対するチカグレラーとクロピドグレルの有効性評価をデータマイニングと機械学習による決定木アプローチで行った

Efficacy assessment of ticagrelor versus clopidogrel in Chinese patients with acute coronary syndrome undergoing percutaneous coronary intervention by data mining and machine-learning decision tree approaches.
  • Ying Xue
  • Ziheng Hu
  • Yankang Jing
  • Hongyi Wu
  • Xiaoye Li
  • Junmei Wang
  • Amy Seybert
  • Xiangqun Xie
  • Qianzhou Lv
  • J Clin Pharm Ther.2020 Jul;doi: 10.1111/jcpt.13172.Epub 2020-07-06.

アンキリンリピートドメイン(R635X)の病原性NFKB2変異体は可変抗体欠損症を引き起こす

Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency.
  • Paul Tuijnenburg
  • Hana Lango Allen
  • Godelieve J de Bree
  • Sinisa Savic
  • Machiel H Jansen
  • Claire Stockdale
  • Ilenia Simeoni
  • Ineke J M Ten Berge
  • Ester M M van Leeuwen
  • James E Thaventhiran
  • Taco W Kuijpers
  • Clin. Immunol..2019 06;203:23-27. S1521-6616(18)30590-4. doi: 10.1016/j.clim.2019.03.010.Epub 2019-04-03.

日常診療における関節リウマチインパクト(RAID)の使用;DAS28寛解とアンメット患者報告アウトカムの同定

Use of rheumatoid arthritis impact of disease (RAID) in routine care; identification of DAS28 remission and unmet patient-reported outcomes.
  • Jatin Mistry
  • Mohammed Sharif
  • Amy Prideaux
  • Catherine Smith
  • Malama Sumbwanyambe
  • Margaret Sibley
  • Lewis Carpenter
  • Melissa Sweeney
  • Patrick Kiely
  • Rheumatol Adv Pract.2020;4(2):rkaa013. rkaa013. doi: 10.1093/rap/rkaa013.Epub 2020-04-27.

循環性腫瘍細胞を有するHER2非増幅型早期乳癌(EORTC 90091-10093、BIG 1-12、Treat CTC)に対するトラスツズマブと観察の比較:無作為化第II相試験

Trastuzumab versus observation for HER2 nonamplified early breast cancer with circulating tumor cells (EORTC 90091-10093, BIG 1-12, Treat CTC): a randomized phase II trial.
  • M Ignatiadis
  • S Litière
  • F Rothe
  • S Riethdorf
  • C Proudhon
  • T Fehm
  • K Aalders
  • H Forstbauer
  • P A Fasching
  • E Brain
  • P Vuylsteke
  • E Guardiola
  • R Lorenz
  • K Pantel
  • K Tryfonidis
  • W Janni
  • M Piccart
  • C Sotiriou
  • B Rack
  • J-Y Pierga
  • Ann. Oncol..2018 08;29(8):1777-1783. S0923-7534(19)34129-8. doi: 10.1093/annonc/mdy211.

内視鏡支援下顎切除術。手術手技と手術縁のコントロール

Endoscopic-assisted maxillectomy: Operative technique and control of surgical margins.
  • Alberto Deganello
  • Marco Ferrari
  • Alberto Paderno
  • Mario Turri-Zanoni
  • Alberto Schreiber
  • Davide Mattavelli
  • Alperen Vural
  • Vittorio Rampinelli
  • Alberto Daniele Arosio
  • Alessandro Ioppi
  • Mario Cherubino
  • Paolo Castelnuovo
  • Piero Nicolai
  • Paolo Battaglia
  • Oral Oncol..2019 06;93:29-38. S1368-8375(19)30102-2. doi: 10.1016/j.oraloncology.2019.04.002.Epub 2019-04-11.

マングローブクラブGoniopsis cruentata(Brachyura, Grapsidae)のエラにおける(Na, K)-ATPase活性の生化学的特性とマグネシウムによるアロステリックな調節

Biochemical Characterization and Allosteric Modulation by Magnesium of (Na, K)-ATPase Activity in the Gills of the Red Mangrove Crab Goniopsis cruentata (Brachyura, Grapsidae).
  • Cintya M Moraes
  • Malson N Lucena
  • Daniela P Garçon
  • Marcelo R Pinto
  • Leonardo M Fabri
  • Rogério O Faleiros
  • Carlos F L Fontes
  • John C McNamara
  • Francisco A Leone
  • J. Membr. Biol..2020 Jun;253(3):229-245. 10.1007/s00232-020-00120-7. doi: 10.1007/s00232-020-00120-7.Epub 2020-05-22.

STING依存性パラクリニーは抗ミトックス治療に応答して乳房腫瘍のアポトーシスプライミングを形成する

STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment.
  • Steven Lohard
  • Nathalie Bourgeois
  • Laurent Maillet
  • Fabien Gautier
  • Aurélie Fétiveau
  • Hamza Lasla
  • Frédérique Nguyen
  • Céline Vuillier
  • Alison Dumont
  • Agnès Moreau-Aubry
  • Morgane Frapin
  • Laurent David
  • Delphine Loussouarn
  • Olivier Kerdraon
  • Mario Campone
  • Pascal Jézéquel
  • Philippe P Juin
  • Sophie Barillé-Nion
  • Nat Commun.2020 01;11(1):259. 10.1038/s41467-019-13689-y. doi: 10.1038/s41467-019-13689-y.Epub 2020-01-14.

グルココルチコイドが白血病細胞におけるBCL-Xの発現制御にASH2Lが重要な役割を果たすことを明らかにした

Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells.
  • Luciana Rocha-Viegas
  • Micaela Silbermins
  • María Florencia Ogara
  • Joaquín Miguel Pellegrini
  • Sol Yanel Nuñez
  • Verónica Edith García
  • Guillermo Pablo Vicent
  • Adali Pecci
  • Biochim Biophys Acta Gene Regul Mech.2020 01;1863(1):194475. S1874-9399(19)30112-9. doi: 10.1016/j.bbagrm.2019.194475.Epub 2019-12-20.

BRAG2aはPSD-95およびエンドフィリン3との相互作用を介して興奮性ポストシナプスにおけるmGluR依存性AMPA受容体の内部化を媒介している

BRAG2a Mediates mGluR-Dependent AMPA Receptor Internalization at Excitatory Postsynapses through the Interaction with PSD-95 and Endophilin 3.
  • Masahiro Fukaya
  • Takeyuki Sugawara
  • Yoshinobu Hara
  • Makoto Itakura
  • Masahiko Watanabe
  • Hiroyuki Sakagami
  • J. Neurosci..2020 May;40(22):4277-4296. JNEUROSCI.1645-19.2020. doi: 10.1523/JNEUROSCI.1645-19.2020.Epub 2020-04-27.

産地の農場で赤外線サーモグラフィーを使用して、輸送やマーケティングにさらされた牛(Bos Taurus)の肉質と生理的反応を予測する

Using infrared thermography on farm of origin to predict meat quality and physiological response in cattle (Bos Taurus) exposed to transport and marketing.
  • Holly Cuthbertson
  • Garth Tarr
  • Kate Loudon
  • Sabrina Lomax
  • Peter White
  • Paul McGreevy
  • Rodney Polkinghorne
  • Luciano A González
  • Meat Sci..2020 Apr;169:108173. S0309-1740(19)30265-7. doi: 10.1016/j.meatsci.2020.108173.Epub 2020-04-29.

クリティカルケアを支える学生たち-COVID-19パンデミックにおけるICUの腐敗を防ぐためのコンテンションプラン:ビョルン・イプセンスのポリオレスを現代に翻訳する

Students Supporting Critical Care - A contention plan to prevent the decompensation of ICUs in the COVID-19 pandemic:Translating Bjorn Ibsens' polio-lessons to modern times.
  • Pedro David Wendel Garcia
  • Paola Massarotto
  • Katja Auinger
  • Reto Andreas Schuepbach
  • Stephanie Klinzing
  • Crit Care.2020 05;24(1):211. 10.1186/s13054-020-02919-1. doi: 10.1186/s13054-020-02919-1.Epub 2020-05-08.

妊娠低酸素は、小胞体/酸化ストレスの増加を介して子宮動脈のCaスパークと自発的な一過性の外向き電流の妊娠誘発性アップレギュレーションを抑制する

Gestational Hypoxia Inhibits Pregnancy-Induced Upregulation of Ca Sparks and Spontaneous Transient Outward Currents in Uterine Arteries Via Heightened Endoplasmic Reticulum/Oxidative Stress.
  • Xiang-Qun Hu
  • Rui Song
  • Monica Romero
  • Chiranjib Dasgupta
  • Joseph Min
  • Daisy Hatcher
  • Daliao Xiao
  • Arlin Blood
  • Sean M Wilson
  • Lubo Zhang
  • Hypertension.2020 Jul;:HYPERTENSIONAHA12015235. doi: 10.1161/HYPERTENSIONAHA.120.15235.Epub 2020-07-20.

MCK1は、気分安定剤バルプロ酸によるイノシトール合成の阻害に必要なミオイノシトールリン酸合成酵素(MIPS)の新規調節因子である

MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition of inositol synthesis by the mood stabilizer valproate.
  • Wenxi Yu
  • Joshua Daniel
  • Dhara Mehta
  • Krishna Rao Maddipati
  • Miriam L Greenberg
  • PLoS ONE.2017;12(8):e0182534. PONE-D-17-20676. doi: 10.1371/journal.pone.0182534.Epub 2017-08-17.

CYP2C9およびCYP2C19の多型がプロゲステロン経口投与または膣内投与されたプロゲステロンの投薬、安全性および代謝に及ぼす影響」に対する編集者へのレター

Letter to the Editor in Response to "Effect of Polymorphisms in CYP2C9 and CYP2C19 on the Disposition, Safety and Metabolism of Progesterone Administrated Orally or Vaginally".
  • Aaron Lazorwitz
  • Christina L Aquilante
  • Jeanelle Sheeder
  • Stephanie Teal
  • Adv Ther.2020 02;37(2):963-964. 10.1007/s12325-019-01195-y. doi: 10.1007/s12325-019-01195-y.Epub 2019-12-24.

糖尿病網膜症ラットにおいて、miR-34αを阻害することで、HMGB1の発現を調節することで網膜細胞のアポトーシスと下流のNF-κB経路を減少させることができました

Inhibiting MiR-34α reduces retinal cell apoptosis and downstream NF-κB pathway in diabetic retinopathy rats through regulating HMGB1 expression.
  • Yibin Ma
  • Yunhong Du
  • Qian Xu
  • Huijing Bao
  • Zhonglian Liu
  • Yingchao Li
  • Wenjing Liu
  • Minerva Med..2020 Jul;S0026-4806.20.06625-2. doi: 10.23736/S0026-4806.20.06625-2.Epub 2020-07-17.

レニン-アンジオテンシン系阻害剤投与下でのレニン-アンジオテンシン-アルドステロン系に対するダパグリフロジンの効果

Effects of dapagliflozin on renin-angiotensin-aldosterone system under renin-angiotensin system inhibitor administration.
  • Masashi Isshiki
  • Ichiro Sakuma
  • Yasuaki Hayashino
  • Takashi Sumita
  • Kazuo Hara
  • Kazuhisa Takahashi
  • Ichiro Shiojima
  • Noriko Satoh-Asahara
  • Hiroji Kitazato
  • Daisuke Ito
  • Daigo Saito
  • Masako Hatano
  • Yuichi Ikegami
  • Shinichiro Iida
  • Akira Shimada
  • Mitsuhiko Noda
  • Endocr. J..2020 Jul;doi: 10.1507/endocrj.EJ20-0222.Epub 2020-07-01.

RNA崩壊因子であるCCR4は、植物サイトラブウイルスのホスホタンパク質によってハイジャックされ、ウイルスの複製を促進する

CCR4, a RNA decay factor, is hijacked by a plant cytorhabdovirus phosphoprotein to facilitate virus replication.
  • Zhen-Jia Zhang
  • Qiang Gao
  • Xiao-Dong Fang
  • Zhi-Hang Ding
  • Dong-Min Gao
  • Wen-Ya Xu
  • Qing Cao
  • Ji-Hui Qiao
  • Yi-Zhou Yang
  • Chenggui Han
  • Ying Wang
  • Xuefeng Yuan
  • Dawei Li
  • Xian-Bing Wang
  • Elife.2020 Mar;9. e53753. doi: 10.7554/eLife.53753.Epub 2020-03-24.

刻々と変化する世界の髄膜炎球菌疾患の疫学と、ワクチン接種による予防の可能性

The everchanging epidemiology of meningococcal disease worldwide and the potential for prevention through vaccination.
  • Sydel Parikh
  • Helen Campbell
  • Julie A Bettinger
  • Lee H Harrison
  • Helen S Marshall
  • Federico Martinon-Torres
  • Marco Aurelio Safadi
  • Zhujun Shao
  • Bingqing Zhu
  • Anne von Gottberg
  • Ray Borrow
  • Mary E Ramsay
  • Shamez N Ladhani
  • J. Infect..2020 Jun;S0163-4453(20)30378-9. doi: 10.1016/j.jinf.2020.05.079.Epub 2020-06-03.

COVID-19の重症度における内臓脂肪率の役割:ドイツにおける単施設横断的パイロット研究のハイライト

The role of visceral adiposity in the severity of COVID-19: highlights from a unicenter cross-sectional pilot study in Germany.
  • Antonia Petersen
  • Keno Bressem
  • Jakob Albrecht
  • Hans-Martin Thieß
  • Janis Vahldiek
  • Bernd Hamm
  • Marcus R Makowski
  • Alexandra Niehues
  • Stefan Niehues
  • Lisa C Adams
  • Metab. Clin. Exp..2020 Jul;:154317. S0026-0495(20)30181-5. doi: 10.1016/j.metabol.2020.154317.Epub 2020-07-13.

免疫関連の有害事象と免疫チェックポイント阻害薬の有効性 食品医薬品局が承認した免疫療法の適応を持つ消化器癌患者における免疫関連の有害事象と免疫チェックポイント阻害薬の有効性

Immune-Related Adverse Events and Immune Checkpoint Inhibitor Efficacy in Patients with Gastrointestinal Cancer with Food and Drug Administration-Approved Indications for Immunotherapy.
  • Satya Das
  • Kristen K Ciombor
  • Sigurdis Haraldsdottir
  • Yoanna Pumpalova
  • Ibrahim H Sahin
  • G Pineda
  • Yu Shyr
  • E P Lin
  • Chih-Yuan Hsu
  • Shih-Kai Chu
  • Laura W Goff
  • Dana B Cardin
  • Mehmet A Bilen
  • George A Fisher
  • Christina Wu
  • Jordan Berlin
  • Oncologist.2020 Jan;doi: 10.1634/theoncologist.2019-0637.Epub 2020-01-14.

イエルシニア・ペスティスにおけるバイオフィルムを媒介とした拡張表現型の進化的選択

Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment.
  • Yujun Cui
  • Boris V Schmid
  • Hanli Cao
  • Xiang Dai
  • Zongmin Du
  • W Ryan Easterday
  • Haihong Fang
  • Chenyi Guo
  • Shanqian Huang
  • Wanbing Liu
  • Zhizhen Qi
  • Yajun Song
  • Huaiyu Tian
  • Min Wang
  • Yarong Wu
  • Bing Xu
  • Chao Yang
  • Jing Yang
  • Xianwei Yang
  • Qingwen Zhang
  • Kjetill S Jakobsen
  • Yujiang Zhang
  • Nils Chr Stenseth
  • Ruifu Yang
  • Nat Commun.2020 01;11(1):281. 10.1038/s41467-019-14099-w. doi: 10.1038/s41467-019-14099-w.Epub 2020-01-15.

ニコチンアミドホスホリボシルトランスフェラーゼ(Nampt)/ニコチンアミドアデニンジヌクレオチド(NAD)軸は、カルシウムハンドリング経路を調節することで心房細動を抑制する

Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway.
  • Duo Feng
  • DongZhu Xu
  • Nobuyuki Murakoshi
  • Kazuko Tajiri
  • Rujie Qin
  • Saori Yonebayashi
  • Yuta Okabe
  • Siqi Li
  • Zixun Yuan
  • Kazutaka Aonuma
  • Masaki Ieda
  • Int J Mol Sci.2020 Jun;21(13). E4655. doi: 10.3390/ijms21134655.Epub 2020-06-30.

t-PA遺伝子のDNAメチル化は、電気けいれん療法を受けているうつ病患者から分離された様々な免疫細胞サブタイプの間で異なる

DNA Methylation of the t-PA Gene Differs Between Various Immune Cell Subtypes Isolated From Depressed Patients Receiving Electroconvulsive Therapy.
  • Nicole Moschny
  • Kirsten Jahn
  • Malek Bajbouj
  • Hannah Benedictine Maier
  • Matthias Ballmaier
  • Abdul Qayyum Khan
  • Christoph Pollak
  • Stefan Bleich
  • Helge Frieling
  • Alexandra Neyazi
  • Front Psychiatry.2020;11:571. doi: 10.3389/fpsyt.2020.00571.Epub 2020-06-19.