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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

α-トコフェロールベースのPEG化リポソームを用いたmicroRNA-134(miR-134)の外因性送達による皮膚扁平上皮癌の効果的な治療法

Exogenous delivery of microRNA-134 (miR-134) using α-tocopherol-based PEGylated liposome for effective treatment in skin squamous cell carcinoma.
  • Chen Jing
  • Li Yan
  • Zhang Wei
  • Zhang Shoumin
  • Yin Guangwen
  • Zhang Jiangan
  • Jia Xuesong
  • Chen Hongxiang
  • Duan Ziyu
  • Li Jianguo
  • Drug Deliv Transl Res.2020 Jun;10.1007/s13346-020-00811-7. doi: 10.1007/s13346-020-00811-7.Epub 2020-06-22.

LncRNAであるFTXは、Kupffer細胞のM1/M2分極を制御することで、非アルコール性脂肪肝疾患から肝細胞癌への進行を抑制することが明らかになった

LncRNA FTX represses the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via regulating the M1/M2 polarization of Kupffer cells.
  • Huajun Wu
  • Zhiwei Zhong
  • Anji Wang
  • Chunhui Yuan
  • Ke Ning
  • Huanhuan Hu
  • Chao Wang
  • Xiangbao Yin
  • Cancer Cell Int..2020;20:266. 1354. doi: 10.1186/s12935-020-01354-0.Epub 2020-06-24.

プレオトロピンは血管内皮増殖因子受容体2に選択的に結合し、αβインテグリンの発現に依存して細胞移動を阻害または刺激する

Pleiotrophin selectively binds to vascular endothelial growth factor receptor 2 and inhibits or stimulates cell migration depending on αβ integrin expression.
  • Margarita Lamprou
  • Pinelopi Kastana
  • Fani Kofina
  • Ηaralampos Tzoupis
  • Spyridoula Barmpoutsi
  • Md Sanaullah Sajib
  • Marina Koutsioumpa
  • Evangelia Poimenidi
  • Aikaterini A Zompra
  • Dimitrios Tassopoulos
  • Effrosyni Choleva
  • Theodore Tselios
  • Constantinos M Mikelis
  • Evangelia Papadimitriou
  • Angiogenesis.2020 Jul;10.1007/s10456-020-09733-x. doi: 10.1007/s10456-020-09733-x.Epub 2020-07-17.

アヤワスカがナイーブユーザーのメンタルヘルスと生活の質に与える影響。縦断的研究と横断的研究の組み合わせ

Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination.
  • Daniel F Jiménez-Garrido
  • María Gómez-Sousa
  • Genís Ona
  • Rafael G Dos Santos
  • Jaime E C Hallak
  • Miguel Ángel Alcázar-Córcoles
  • José Carlos Bouso
  • Sci Rep.2020 Mar;10(1):4075. 10.1038/s41598-020-61169-x. doi: 10.1038/s41598-020-61169-x.Epub 2020-03-05.

酵母細胞壁由来のマンノプロテインの活性画分は、成犬および高齢犬の自然免疫および獲得免疫を刺激する

Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs.
  • F S A Kroll
  • T C Putarov
  • L Zaine
  • K S Venturini
  • C G Aoki
  • J P F Santos
  • V Pedrinelli
  • T H A Vendramini
  • M A Brunetto
  • A C Carciofi
  • Anim. Feed Sci. Technol..2020 Mar;261:114392. S0377-8401(18)31570-0. doi: 10.1016/j.anifeedsci.2020.114392.Epub 2020-01-10.

海洋南極のエコロジー氷河における氷晶石穴生態系のビオトープとバイオセノシス

Biotope and biocenosis of cryoconite hole ecosystems on Ecology Glacier in the maritime Antarctic.
  • Jakub Buda
  • Edyta Łokas
  • Mirosława Pietryka
  • Dorota Richter
  • Wojciech Magowski
  • Nataliia S Iakovenko
  • Dorota L Porazinska
  • Tomasz Budzik
  • Mariusz Grabiec
  • Jakub Grzesiak
  • Piotr Klimaszyk
  • Paweł Gaca
  • Krzysztof Zawierucha
  • Sci. Total Environ..2020 Jul;724:138112. S0048-9697(20)31625-9. doi: 10.1016/j.scitotenv.2020.138112.Epub 2020-03-24.

スプライシングとマイクロプロセッサー複合体の拮抗は、細胞周期再突入のためのLnc-MIRHGの血清誘発処理を決定する

Antagonism between Splicing and Microprocessor complex Dictates the Serum-induced Processing of Lnc-MIRHG for Efficient Cell Cycle Re-entry.
  • Qinyu Sun
  • Qinyu Hao
  • Yo-Chuen Lin
  • You Jin Song
  • Sushant Bangru
  • Waqar Arif
  • Vidisha Tripathi
  • Yang Zhang
  • Jung-Hyun Cho
  • Susan M Freier
  • Lisa Jenkins
  • Jian Ma
  • Je-Hyun Yoon
  • Auinash Kalsotra
  • Ashish Lal
  • Supriya G Prasanth
  • Kannanganattu V Prasanth
  • RNA.2020 Jul;rna.075309.120. doi: 10.1261/rna.075309.120.Epub 2020-07-16.

カーボベルデにおける2015-2016年のジカウイルスアウトブレイクのゲノム疫学

Genomic Epidemiology of 2015-2016 Zika Virus Outbreak in Cape Verde.
  • Oumar Faye
  • Maria de Lourdes Monteiro
  • Bram Vrancken
  • Matthieu Prot
  • Sebastian Lequime
  • Maryam Diarra
  • Oumar Ndiaye
  • Tomas Valdez
  • Sandra Tavarez
  • Jessica Ramos
  • Silvânia da Veiga Leal
  • Cecilio Pires
  • Antonio Moreira
  • Maria Filomena Tavares
  • Linete Fernandes
  • Jorge Noel Barreto
  • Maria do Céu Teixeira
  • Maria da Luz de Lima Mendonça
  • Carolina Cardoso da Silva Leite Gomes
  • Mariano Salazar Castellon
  • Laurence Ma
  • Frédéric Lemoine
  • Fabiana Gámbaro-Roglia
  • Déborah Delaune
  • Gamou Fall
  • Ibrahima Socé Fall
  • Mamadou Diop
  • Anavaj Sakuntabhai
  • Cheikh Loucoubar
  • Philippe Lemey
  • Edward C Holmes
  • Ousmane Faye
  • Amadou Alpha Sall
  • Etienne Simon-Loriere
  • Emerging Infect. Dis..2020 Jun;26(6):1084-1090. doi: 10.3201/eid2606.190928.

エクスパンシン遺伝子ファミリーのゲノムワイドな同定により、エクスパンシン遺伝子が綿花の繊維細胞の成長に関与していることが明らかになった

Genome-wide identification of the expansin gene family reveals that expansin genes are involved in fibre cell growth in cotton.
  • Li-Min Lv
  • Dong-Yun Zuo
  • Xing-Fen Wang
  • Hai-Liang Cheng
  • You-Ping Zhang
  • Qiao-Lian Wang
  • Guo-Li Song
  • Zhi-Ying Ma
  • BMC Plant Biol..2020 May;20(1):223. 10.1186/s12870-020-02362-y. doi: 10.1186/s12870-020-02362-y.Epub 2020-05-19.

微粒子状物質曝露と乳房腫瘍および隣接正常乳房組織における遺伝子発現経路との関与

Involvement of fine particulate matter exposure with gene expression pathways in breast tumor and adjacent-normal breast tissue.
  • Natalie C DuPré
  • Yujing J Heng
  • Benjamin A Raby
  • Kimberly Glass
  • Jaime E Hart
  • Jen-Hwa Chu
  • Catherine Askew
  • A Heather Eliassen
  • Susan E Hankinson
  • Peter Kraft
  • Francine Laden
  • Rulla M Tamimi
  • Environ. Res..2020 Jul;186:109535. S0013-9351(20)30428-X. doi: 10.1016/j.envres.2020.109535.Epub 2020-04-15.

ショウジョウバエメラノガスターの性ペプチドの構造:水酸化イソロイシンの同定とアミノ酸の水酸化パターンの系統変化

The structure of the Drosophila melanogaster sex peptide: Identification of hydroxylated isoleucine and a strain variation in the pattern of amino acid hydroxylation.
  • Sebastian Sturm
  • Adam Dowle
  • Neil Audsley
  • R Elwyn Isaac
  • Insect Biochem. Mol. Biol..2020 Jun;124:103414. S0965-1748(20)30103-X. doi: 10.1016/j.ibmb.2020.103414.Epub 2020-06-24.

危機的に絶滅の危機に瀕している単一島嶼の固有種の鳥では、高いMHC遺伝子コピー数がホモ接合にもかかわらず多様性を維持しているが、MHCに基づく仲間選択の証拠はない

High MHC gene copy number maintains diversity despite homozygosity in a Critically Endangered single-island endemic bird, but no evidence of MHC-based mate choice.
  • Martin Stervander
  • Elisa G Dierickx
  • Jack Thorley
  • M de L Brooke
  • Helena Westerdahl
  • Mol. Ecol..2020 May;doi: 10.1111/mec.15471.Epub 2020-05-16.

肺サルコイドーシスにおける高用量ブデゾニド吸入開始後の臨床経過と血清KL-6レベルの顕著な改善

Remarkable Improvement in Clinical Course and Serum KL-6 Levels after Initiation of High-Dose Inhaled Budesonide in Pulmonary Sarcoidosis.
  • Yoshitaka Morimatsu
  • Masaki Okamoto
  • Tomotaka Kawayama
  • Yusuke Mizoguchi
  • Haruki Imaoka
  • Hideo Ogino
  • Taketoshi Kawazu
  • Tatsuya Ishitake
  • Tomoaki Hoshino
  • Kurume Med J.2020 Jul;66(1):71-75. doi: 10.2739/kurumemedj.MS661003.Epub 2020-05-01.

糖尿病性肩関節炎患者における肩の痛み、機能、可動域の改善における橈骨体外衝撃波治療と超音波ガイド下低用量関節内ステロイド注射の有効性

Effectiveness of radial extracorporeal shock-wave therapy versus ultrasound-guided low-dose intra-articular steroid injection in improving shoulder pain, function, and range of motion in diabetic patients with shoulder adhesive capsulitis.
  • Tasneem El Desouky Mohammed El Naggar
  • Ahmed Ibrahim Elsayed Maaty
  • Aly Elsayed Mohamed
  • J Shoulder Elbow Surg.2020 Jul;29(7):1300-1309. S1058-2746(20)30265-2. doi: 10.1016/j.jse.2020.03.005.

妊婦の血糖コントロールマーカーと母体および新生児の転帰との関係に関する多施設共同全包括的プロスペクティブ研究

A multicenter all-inclusive prospective study on the relationship between glycemic control markers and maternal and neonatal outcomes in pregnant women.
  • Xiaoming Zhang
  • Yumei Wei
  • Ling Fan
  • Yangyu Zhao
  • Yufeng Li
  • Yanjun Liu
  • Juming Lu
  • Linong Ji
  • Huixia Yang
  • J. Matern. Fetal. Neonatal. Med..2020 Jul;:1-8. doi: 10.1080/14767058.2019.1678139.Epub 2020-07-15.

ヒト感染性マラリア寄生虫におけるRH5複合体構成要素CyRPAとRIPRの多様な役割

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.
  • Ellen Knuepfer
  • Katherine E Wright
  • Surendra Kumar Prajapati
  • Thomas A Rawlinson
  • Franziska Mohring
  • Marion Koch
  • Oliver R Lyth
  • Steven A Howell
  • Elizabeth Villasis
  • Ambrosius P Snijders
  • Robert W Moon
  • Simon J Draper
  • Anna Rosanas-Urgell
  • Matthew K Higgins
  • Jake Baum
  • Anthony A Holder
  • PLoS Pathog..2019 06;15(6):e1007809. PPATHOGENS-D-18-01406. doi: 10.1371/journal.ppat.1007809.Epub 2019-06-11.

2 型糖尿病または原発性高コレステロール血症患者における高オンアスピリン血小板反応性とスーパーオキシドジスムターゼ活性低下との関連

Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia.
  • Cristina Barale
  • Franco Cavalot
  • Chiara Frascaroli
  • Katia Bonomo
  • Alessandro Morotti
  • Angelo Guerrasio
  • Isabella Russo
  • Int J Mol Sci.2020 Jul;21(14). E4983. doi: 10.3390/ijms21144983.Epub 2020-07-15.

水性媒体からビスフェノールA(BPA)を除去するためのスイッチグラス(Panicum virgatum)(米国産2品種)のファイトレメディエーションの可能性

Phytoremediation potential of switchgrass (Panicum virgatum), two United States native varieties, to remove bisphenol-A (BPA) from aqueous media.
  • Jacob C Phouthavong-Murphy
  • Alyssa K Merrill
  • Stephanie Zamule
  • David Giacherio
  • Beverly Brown
  • Carol Roote
  • Padmini Das
  • Sci Rep.2020 01;10(1):835. 10.1038/s41598-019-56655-w. doi: 10.1038/s41598-019-56655-w.Epub 2020-01-21.

思春期の鎖骨骨折の記述的疫学。FACTS(思春期鎖骨外傷および手術後の機能)プロスペクティブ多施設コホート研究の結果

Descriptive Epidemiology of Adolescent Clavicle Fractures: Results From the FACTS (Function after Adolescent Clavicle Trauma and Surgery) Prospective, Multicenter Cohort Study.
  • Henry B Ellis
  • Ying Li
  • Donald S Bae
  • Leslie A Kalish
  • Philip L Wilson
  • Andrew T Pennock
  • Jeffrey J Nepple
  • Samuel C Willimon
  • David D Spence
  • Nirav K Pandya
  • Mininder S Kocher
  • Eric W Edmonds
  • Frances A Farley
  • J Eric Gordon
  • Derek M Kelly
  • Michael T Busch
  • Coleen S Sabatini
  • Benton E Heyworth
  • Orthop J Sports Med.2020 May;8(5):2325967120921344. 10.1177_2325967120921344. doi: 10.1177/2325967120921344.Epub 2020-05-29.

ClbR は大腸菌におけるコリバクチン遺伝子発現の鍵となる転写活性化因子である

ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli.
  • Alexander Wallenstein
  • Nadine Rehm
  • Marina Brinkmann
  • Martina Selle
  • Nadège Bossuet-Greif
  • Daniel Sauer
  • Boyke Bunk
  • Cathrin Spröer
  • Haleluya Tesfaye Wami
  • Stefan Homburg
  • Rudolf von Bünau
  • Simone König
  • Jean-Philippe Nougayrède
  • Jörg Overmann
  • Eric Oswald
  • Rolf Müller
  • Ulrich Dobrindt
  • mSphere.2020 Jul;5(4). e00591-20. doi: 10.1128/mSphere.00591-20.Epub 2020-07-15.

イタリアにおけるロンゴバルド人の移動性の指標としてのストロンチウムと酸素同位体:ポベグリーノ・ヴェロネーゼでの調査

Strontium and oxygen isotopes as indicators of Longobards mobility in Italy: an investigation at Povegliano Veronese.
  • Guendalina Francisci
  • Ileana Micarelli
  • Paola Iacumin
  • Francesca Castorina
  • Fabio Di Vincenzo
  • Martina Di Matteo
  • Caterina Giostra
  • Giorgio Manzi
  • Mary Anne Tafuri
  • Sci Rep.2020 Jul;10(1):11678. 10.1038/s41598-020-67480-x. doi: 10.1038/s41598-020-67480-x.Epub 2020-07-15.

LPAR2受容体の活性化は、マウス大腸における放射線誘発性のアピカルジャンクショナルコンプレックスの破壊と粘膜バリア機能障害を減衰させる

LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.
  • Pradeep K Shukla
  • Avtar S Meena
  • Ruchika Gangwar
  • Erzsebet Szabo
  • Andrea Balogh
  • Sue Chin Lee
  • Alain Vandewalle
  • Gabor Tigyi
  • RadhaKrishna Rao
  • FASEB J..2020 Jul;doi: 10.1096/fj.202000544R.Epub 2020-07-12.

ミクロンおよびサブミクロンサイズのコアシェルキャリアのラジオラベリング戦略を研究する

Radiolabeling Strategies of Micron- and Submicron-Sized Core-Shell Carriers for Studies.
  • Mikhail V Zyuzin
  • Dmitrii Antuganov
  • Yana V Tarakanchikova
  • Timofey E Karpov
  • Tatiana V Mashel
  • Elena N Gerasimova
  • Oleksii O Peltek
  • Nominé Alexandre
  • Stéphanie Bruyere
  • Yulia A Kondratenko
  • Albert R Muslimov
  • Alexander S Timin
  • ACS Appl Mater Interfaces.2020 Jul;12(28):31137-31147. doi: 10.1021/acsami.0c06996.Epub 2020-07-02.

第二世代クリオバルーンアブレーション後の心房不整脈再発のメカニズムを検討した

The mechanisms of recurrent atrial arrhythmias after second-generation cryoballoon ablation.
  • Shinsuke Miyazaki
  • Tomoki Horie
  • Hitoshi Hachiya
  • Kanae Hasegawa
  • Takatsugu Kajiyama
  • Tomonori Watanabe
  • Hiroaki Nakamura
  • Eri Ishikawa
  • Moe Mukai
  • Daisetsu Aoyama
  • Minoru Nodera
  • Kenichi Kaseno
  • Yoshito Iesaka
  • Hiroshi Tada
  • Am. Heart J..2020 03;221:29-38. S0002-8703(19)30342-4. doi: 10.1016/j.ahj.2019.12.002.Epub 2019-12-16.

ナノスケールのクルクミンとレスベラトロールの、変調された電気ハイパーサーミアによる大腸がんにおける宿主免疫と抗腫瘍効果の潜在的な強化

Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia.
  • I-Ming Kuo
  • Jih-Jong Lee
  • Yu-Shan Wang
  • Hsin-Chien Chiang
  • Cheng-Chung Huang
  • Pei-Jong Hsieh
  • Winston Han
  • Chiao-Hsu Ke
  • Albert T C Liao
  • Chen-Si Lin
  • BMC Cancer.2020 Jun;20(1):603. 10.1186/s12885-020-07072-0. doi: 10.1186/s12885-020-07072-0.Epub 2020-06-29.

黒リンナノシートを用いた花のような3次元MOFのMnドーピングによる階層的な花弁成長を利用したヒトストレス誘導性ホスホタンパク質1の電気化学的アプタセンサの開発

Mn-Doping-induced hierarchical petal growth of a flower-like 3D MOF assembled with black phosphorous nanosheets as an electrochemical aptasensor of human stress-induced phosphoprotein 1.
  • Zejun Sun
  • Hui Jin
  • Yujiao Sun
  • Xiaowen Jiang
  • Rijun Gui
  • Nanoscale.2020 Jul;12(27):14538-14548. doi: 10.1039/d0nr02342f.Epub 2020-07-02.

治癒療法が適応とならない小型(5cm以下)肝細胞がんに対する定位放射線療法。単群、第II相臨床試験の結果

Stereotactic body radiation therapy for small (≤5 cm) hepatocellular carcinoma not amenable to curative treatment: Results of a single-arm, phase II clinical trial.
  • Sang Min Yoon
  • So Yeon Kim
  • Young-Suk Lim
  • Kang Mo Kim
  • Ju Hyun Shim
  • Danbi Lee
  • Jihyun An
  • Jinhong Jung
  • Jong Hoon Kim
  • Han Chu Lee
  • Clin Mol Hepatol.2020 Jul;cmh.2020.0038. doi: 10.3350/cmh.2020.0038.Epub 2020-07-10.

リドカイン、ロピバカイン、ブピバカインのヒト脂肪由来間葉系幹細胞の生存率および代謝活性に対する細胞毒性の違い

Differences in cytotoxicity of lidocaine, ropivacaine, bupivacaine on the viability and metabolic activity of human adipose-derived mesenchymal stem cells.
  • Eva Kubrova
  • Min Su
  • Catalina Galeano-Garces
  • M Lizeth Galvan
  • Sofia Jerez
  • Allan B Dietz
  • Jay Smith
  • Wenchun Qu
  • Andre J van Wijnen
  • Am J Phys Med Rehabil.2020 Jul;doi: 10.1097/PHM.0000000000001529.Epub 2020-07-09.

2種類のレニン-アンジオテンシン系阻害薬のラットにおけるβ因子XIIaに関連したニュープレッサー蛋白質によって誘導される高血圧に対する効果

The effects of two types of renin-angiotensin system inhibitors on the hypertension induced by new pressor protein associated with beta-factor XIIa in rats.
  • Akbar Pejhan
  • Ali Gohari
  • Mohammad Hassan Rakhshani
  • Peter C Papageorgiou
  • Muhammad Ibrar Mustafa
  • Rahim Golmohammadi
  • Res Pharm Sci.2020 Apr;15(2):174-181. RPS-15-174. doi: 10.4103/1735-5362.283817.Epub 2020-05-11.

臼歯部切歯低小石灰化の影響を受けた切歯に対するカゼインホスホペプチドアモルファスリン酸カルシウムによるマイクロアブレーションおよびマイクロアブレーション後の審美性の比較評価

Comparative Evaluation of Esthetics after Microabrasion and Microabrasion followed by Casein Phosphopeptide-Amorphous Calcium Fluoride Phosphate on Molar Incisor Hypomineralization-Affected Incisors.
  • Ranu Bhandari
  • Seema Thakur
  • Parul Singhal
  • Deepak Chauhan
  • Cheranjeevi Jayam
  • Teerthesh Jain
  • Contemp Clin Dent.2019 Jan-Mar;10(1):9-15. CCD-10-9. doi: 10.4103/ccd.ccd_852_17.

心房細動および/またはフラッターを有する患者における、除細動時またはアブレーション時の抑うつ症状と不安の探索

Exploring Depressive Symptoms and Anxiety Among Patients With Atrial Fibrillation and/or Flutter at the Time of Cardioversion or Ablation.
  • Theresa A Koleck
  • Shazia A Mitha
  • Angelo Biviano
  • Billy A Caceres
  • Elizabeth J Corwin
  • Isaac Goldenthal
  • Ruth Masterson Creber
  • Meghan Reading Turchioe
  • Kathleen T Hickey
  • Suzanne Bakken
  • J Cardiovasc Nurs.2020 Jul;doi: 10.1097/JCN.0000000000000723.Epub 2020-07-13.

イングランド、スコットランドとノルウェー、スウェーデンとの歯科および口腔感染症に対する抗菌薬処方の比較と、2010年から2016年までの全国消費に対する相対的な貢献

Comparison of antimicrobial prescribing for dental and oral infections in England and Scotland with Norway and Sweden and their relative contribution to national consumption 2010-2016.
  • Andrew Smith
  • Rania Al-Mahdi
  • William Malcolm
  • Nikolaus Palmer
  • Gunnar Dahlen
  • Mohammed Al-Haroni
  • BMC Oral Health.2020 Jun;20(1):172. 10.1186/s12903-020-01163-x. doi: 10.1186/s12903-020-01163-x.Epub 2020-06-16.

S1ドメインRNA結合タンパク質(CvfD)は、D39における寒冷感受性、リン酸輸送、および病原性を媒介する新しい転写後調節因子である

S1-Domain RNA-Binding Protein (CvfD) Is a New Post-Transcriptional Regulator That Mediates Cold Sensitivity, Phosphate Transport, and Virulence in D39.
  • Dhriti Sinha
  • Jiaqi J Zheng
  • Ho-Ching Tiffany Tsui
  • John D Richardson
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  • J. Bacteriol..2020 Jun;JB.00245-20. doi: 10.1128/JB.00245-20.Epub 2020-06-29.

小児肥満に対する包括的介入が低年齢児の食生活の多様性に及ぼす影響。中国における学校ベースの無作為化比較試験からのエビデンス

The effect of comprehensive intervention for childhood obesity on dietary diversity among younger children: Evidence from a school-based randomized controlled trial in China.
  • Haiquan Xu
  • Olivier Ecker
  • Qian Zhang
  • Songming Du
  • Ailing Liu
  • Yanping Li
  • Xiaoqi Hu
  • Tingyu Li
  • Hongwei Guo
  • Ying Li
  • Guifa Xu
  • Weijia Liu
  • Jun Ma
  • Junmao Sun
  • Kevin Chen
  • Guansheng Ma
  • PLoS ONE.2020;15(7):e0235951. PONE-D-19-24892. doi: 10.1371/journal.pone.0235951.Epub 2020-07-17.

食事誘発性肥満モデルにおけるクロピドグレル抵抗性はインターロイキン-1受容体によって媒介され、DT-678で克服される

Clopidogrel Resistance in a Murine Model of Diet-Induced Obesity Is Mediated by the Interleukin-1 Receptor and Overcome With DT-678.
  • Yifang Sun
  • Jessica Venugopal
  • Chiao Guo
  • Yanbo Fan
  • Jianping Li
  • Yanjun Gong
  • Y Eugene Chen
  • Haoming Zhang
  • Daniel T Eitzman
  • Arterioscler. Thromb. Vasc. Biol..2020 06;40(6):1533-1542. doi: 10.1161/ATVBAHA.120.314146.Epub 2020-04-09.

デンマークにおける同種造血幹細胞移植後の慢性眼球移植片対宿主病-条件付けレジメンに応じた成人のリスクと発生率に関連する因子

Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark - factors associated with risks and rates in adults according to conditioning regimen.
  • Helene Jeppesen
  • Henrik Sengeløv
  • Frank Eriksson
  • Jens Folke Kiilgaard
  • Susanne Tvede Andersen
  • Jens Lindegaard
  • Hanne Olsen Julian
  • Steffen Heegaard
  • Bone Marrow Transplant..2020 Jul;10.1038/s41409-020-0993-3. doi: 10.1038/s41409-020-0993-3.Epub 2020-07-12.

CBCTを用いた無外傷性副鼻腔補強術のコンピュータベースの定量化

Computer-based quantification of an atraumatic sinus augmentation technique using CBCT.
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  • A M Inchingolo
  • P I Georgakopoulos
  • A D Inchingolo
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  • E Fotopoulou
  • S Tsantis
  • I P Georgakopoulos
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  • A Greco Lucchina
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  • J. Biol. Regul. Homeost. Agents.2019 Nov-Dec;33(6 Suppl. 2):31-39. 4.

MAPTハプロタイプ層別化GWASにより、ADリスクバリアントの差動関連が明らかになった

MAPT haplotype-stratified GWAS reveals differential association for AD risk variants.
  • Samantha L Strickland
  • Joseph S Reddy
  • Mariet Allen
  • Aurelie N'songo
  • Jeremy D Burgess
  • Morgane M Corda
  • Travis Ballard
  • Xue Wang
  • Minerva M Carrasquillo
  • Joanna M Biernacka
  • Gregory D Jenkins
  • Shubhabrata Mukherjee
  • Kevin Boehme
  • Paul Crane
  • John S Kauwe
  • Nilüfer Ertekin-Taner
  • Alzheimers Dement.2020 Jul;16(7):983-1002. doi: 10.1002/alz.12099.Epub 2020-05-13.

Erratum to '10-year Mortality, Disease Progression, and Treatment-related Side Effects in the Men with Localised Prostate Cancer from ProtecT Randomised Controlled Trial According to the Treatment Received' European Urology 77 (2020) 320-330

Erratum to 'Ten-year Mortality, Disease Progression, and Treatment-related Side Effects in Men with Localised Prostate Cancer from the ProtecT Randomised Controlled Trial According to Treatment Received' [European Urology 77 (2020) 320-330].
  • David E Neal
  • Chris Metcalfe
  • Jenny L Donovan
  • J Athene Lane
  • Michael Davis
  • Grace J Young
  • Susan J Dutton
  • Eleanor I Walsh
  • Richard M Martin
  • Tim J Peters
  • Emma L Turner
  • Malcolm Mason
  • Richard Bryant
  • Prasad Bollina
  • James Catto
  • Alan Doherty
  • David Gillatt
  • Vincent Gnanapragasam
  • Peter Holding
  • Owen Hughes
  • Roger Kockelbergh
  • Howard Kynaston
  • Jon Oxley
  • Alan Paul
  • Edgar Paez
  • Derek J Rosario
  • Edward Rowe
  • John Staffurth
  • Doug G Altman
  • Freddie C Hamdy
  • Eur. Urol..2020 Jul;S0302-2838(20)30392-4. doi: 10.1016/j.eururo.2020.05.030.Epub 2020-07-02.

ヒト細胞におけるコンビナトリアル遺伝学的スクリーニングのためのAsCas12aの最適化

Optimization of AsCas12a for combinatorial genetic screens in human cells.
  • Peter C DeWeirdt
  • Kendall R Sanson
  • Annabel K Sangree
  • Mudra Hegde
  • Ruth E Hanna
  • Marissa N Feeley
  • Audrey L Griffith
  • Teng Teng
  • Samantha M Borys
  • Christine Strand
  • J Keith Joung
  • Benjamin P Kleinstiver
  • Xuewen Pan
  • Alan Huang
  • John G Doench
  • Nat. Biotechnol..2020 Jul;10.1038/s41587-020-0600-6. doi: 10.1038/s41587-020-0600-6.Epub 2020-07-13.

不確定な腎腫瘤に対する造影超音波検査が患者の臨床管理に及ぼす影響。2施設からのレトロスペクティブな分析。2施設からのレトロスペクティブ分析

Effects of Contrast-Enhanced Ultrasound of Indeterminate Renal Masses on Patient Clinical Management: Retrospective Analysis from Two Institutions: Retrospective Analysis From 2 Institutions.
  • John R Eisenbrey
  • Aya Kamaya
  • Sriharsha Gummadi
  • Kristen Bird
  • David Burrowes
  • Diego Arias
  • Costas D Lallas
  • Edouard J Trabulsi
  • Andrej Lyshchik
  • J Ultrasound Med.2020 Jul;doi: 10.1002/jum.15383.Epub 2020-07-13.

ブタ精子を17℃で液体保存している間の精液中の血漿の存在は、精子の体外容量化とアクロソームエクソサイトーシスを誘発する能力を調節している

The Presence of Seminal Plasma during Liquid Storage of Pig Spermatozoa at 17 °C Modulates Their Ability to Elicit In Vitro Capacitation and Trigger Acrosomal Exocytosis.
  • Ana Paula Pinoti Pavaneli
  • Sandra Recuero
  • Bruna Resende Chaves
  • Estela Garcia-Bonavila
  • Marc Llavanera
  • Elisabeth Pinart
  • Sergi Bonet
  • André Furugen Cesar De Andrade
  • Marc Yeste
  • Int J Mol Sci.2020 Jun;21(12). E4520. doi: 10.3390/ijms21124520.Epub 2020-06-25.

抗レトロウイルス療法にもかかわらず、潜在的な病原性細菌を有するHIV感染者における気道マイクロバイオームの富化

Enrichment of the airway microbiome in people living with HIV with potential pathogenic bacteria despite antiretroviral therapy.
  • Sylvia A D Rofael
  • James Brown
  • Elisha Pickett
  • Margaret Johnson
  • John R Hurst
  • David Spratt
  • Marc Lipman
  • Timothy D McHugh
  • EClinicalMedicine.2020 Jul;24:100427. S2589-5370(20)30171-1. doi: 10.1016/j.eclinm.2020.100427.Epub 2020-06-27.

ヒト髄芽細胞腫細胞における短期ヘッジホッグシグナル伝達のリン酸化プロテオミクス

Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells.
  • Tamara Scheidt
  • Oliver Alka
  • Humberto Gonczarowska-Jorge
  • Wolfgang Gruber
  • Florian Rathje
  • Margherita Dell'Aica
  • Marc Rurik
  • Oliver Kohlbacher
  • René P Zahedi
  • Fritz Aberger
  • Christian G Huber
  • Cell Commun. Signal.2020 Jun;18(1):99. 10.1186/s12964-020-00591-0. doi: 10.1186/s12964-020-00591-0.Epub 2020-06-23.

気候温暖化に伴う範囲拡大と在来植物の環境下における土壌線虫群集の緯度的変化

Latitudinal variation in soil nematode communities under climate warming-related range-expanding and native plants.
  • Rutger A Wilschut
  • Stefan Geisen
  • Henk Martens
  • Olga Kostenko
  • Mattias de Hollander
  • Freddy C Ten Hooven
  • Carolin Weser
  • L Basten Snoek
  • Janneke Bloem
  • Danka Caković
  • Tatjana Čelik
  • Kadri Koorem
  • Nikos Krigas
  • Marta Manrubia
  • Kelly S Ramirez
  • Maria A Tsiafouli
  • Branko Vreš
  • Wim H van der Putten
  • Glob Chang Biol.2019 08;25(8):2714-2726. doi: 10.1111/gcb.14657.Epub 2019-05-20.

術前に目立たない腎機能を有する患者における腎部分切除術後の慢性腎臓病-好奇心か、それとも関連する問題か?

Chronic Kidney Disease After Partial Nephrectomy in Patients With Preoperative Inconspicuous Renal Function - Curiosity or Relevant Issue?
  • Malin Nientiedt
  • Riccardo Bertolo
  • Riccardo Campi
  • Umberto Capitanio
  • Selcuk Erdem
  • Önder Kara
  • Tobias Klatte
  • Alessandro Larcher
  • Maria Carmen Mir
  • Idir Ouzaid
  • Eduard Roussel
  • Maciej Salagierski
  • Frank Waldbillig
  • Maximillian Christian Kriegmair
  • Clin Genitourin Cancer.2020 May;S1558-7673(20)30115-4. doi: 10.1016/j.clgc.2020.05.007.Epub 2020-05-20.

HDAC1/2 阻害剤ロミデプシンがマウスの DEN 誘発肝細胞発癌を抑制することを明らかにした

HDAC1/2 Inhibitor Romidepsin Suppresses DEN-Induced Hepatocellular Carcinogenesis in Mice.
  • Hara Afaloniati
  • Katerina Angelopoulou
  • Alexander Giakoustidis
  • Alexandros Hardas
  • Athanasios Pseftogas
  • Kali Makedou
  • Athanasios Gargavanis
  • Thomas Goulopoulos
  • Stavros Iliadis
  • Vasileios Papadopoulos
  • Apostolos Papalois
  • George Mosialos
  • Theofilos Poutahidis
  • Dimitrios Giakoustidis
  • Onco Targets Ther.2020;13:5575-5588. 250233. doi: 10.2147/OTT.S250233.Epub 2020-06-15.

抗癌活性を有する新規ヒストン脱アセチル化酵素阻害剤としてのクマリン系N-ヒドロキシシンナムアミド誘導体の設計、合成および生物学的評価

Design, synthesis and biological evaluation of coumarin-based N-hydroxycinnamamide derivatives as novel histone deacetylase inhibitors with anticancer activities.
  • Jiaoli Ding
  • Jing Liu
  • Zhipeng Zhang
  • Jie Guo
  • Maojun Cheng
  • Yang Wan
  • Rikang Wang
  • Yuanying Fang
  • Zhiyu Guan
  • Yi Jin
  • Sai-Sai Xie
  • Bioorg. Chem..2020 Jun;101:104023. S0045-2068(20)31320-1. doi: 10.1016/j.bioorg.2020.104023.Epub 2020-06-17.

一次乳児シリーズ期間中に髄膜炎球菌血清群C結合ワクチンと併用して投与されるDTaP5-HB-IPV-Hibワクチンの無作為化臨床試験

Randomized clinical trial of DTaP5-HB-IPV-Hib vaccine administered concomitantly with meningococcal serogroup C conjugate vaccines during the primary infant series.
  • Jennifer L Oliver
  • Christine Sadorge
  • Florence Boisnard
  • Matthew D Snape
  • Richard Tomlinson
  • Rebecca Mann
  • Peter Rudd
  • Shyam Bhakthavalsala
  • Saul N Faust
  • Paul T Heath
  • Stephen M Hughes
  • Ray Borrow
  • Stéphane Thomas
  • Adam Finn
  • Vaccine.2020 Jul;S0264-410X(20)30787-8. doi: 10.1016/j.vaccine.2020.06.015.Epub 2020-07-09.

妊娠糖尿病に合併した妊娠から降臨した子供の糖尿病/心血管/脳血管疾患関連microRNAの大幅に変化した発現プロファイル-心血管リスクの増加のためのいくつかの可能な理由の一つ

Substantially Altered Expression Profile of Diabetes/Cardiovascular/Cerebrovascular Disease Associated microRNAs in Children Descending from Pregnancy Complicated by Gestational Diabetes Mellitus-One of Several Possible Reasons for an Increased Cardiovascular Risk.
  • Ilona Hromadnikova
  • Katerina Kotlabova
  • Lenka Dvorakova
  • Ladislav Krofta
  • Jan Sirc
  • Cells.2020 Jun;9(6). E1557. doi: 10.3390/cells9061557.Epub 2020-06-26.

ブファリンは、アンドロゲン受容体の脱リン酸化と細胞周期関連キナーゼ分解を介して、B型肝炎ウイルス関連肝細胞癌の発生を抑制することが明らかになった

Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation.
  • Zhuo Yu
  • Hai Feng
  • Yunhui Zhuo
  • Man Li
  • Xiaojun Zhu
  • Lingying Huang
  • Xin Zhang
  • Zhenhua Zhou
  • Chao Zheng
  • Yun Jiang
  • Fan Le
  • Dae-Yeul Yu
  • Alfred Szelok Cheng
  • Xuehua Sun
  • Yueqiu Gao
  • Cell Oncol (Dordr).2020 Jul;10.1007/s13402-020-00546-0. doi: 10.1007/s13402-020-00546-0.Epub 2020-07-04.