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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

HIV-1逆転写酵素は、ツイストの活性酸素依存性アップレギュレーションを介して腫瘍の成長と転移形成を促進する

HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist.
  • Ekaterina Bayurova
  • Juris Jansons
  • Dace Skrastina
  • Olga Smirnova
  • Dzeina Mezale
  • Anastasia Kostyusheva
  • Dmitry Kostyushev
  • Stefan Petkov
  • Philip Podschwadt
  • Vladimir Valuev-Elliston
  • Sviataslau Sasinovich
  • Sergey Korolev
  • Per Warholm
  • Anastasia Latanova
  • Elizaveta Starodubova
  • Amir Tukhvatulin
  • Oleg Latyshev
  • Renat Selimov
  • Pavel Metalnikov
  • Alexander Komarov
  • Olga Ivanova
  • Tatiana Gorodnicheva
  • Sergey Kochetkov
  • Marina Gottikh
  • Ilze Strumfa
  • Alexander Ivanov
  • Ilya Gordeychuk
  • Maria Isaguliants
  • Oxid Med Cell Longev.2019;2019:6016278. doi: 10.1155/2019/6016278.Epub 2019-12-02.

単細胞トランスクリプトミクスを用いた乳がんにおける骨髄由来サプレッサー細胞の出現の定義

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics.
  • Hamad Alshetaiwi
  • Nicholas Pervolarakis
  • Laura Lynn McIntyre
  • Dennis Ma
  • Quy Nguyen
  • Jan Akara Rath
  • Kevin Nee
  • Grace Hernandez
  • Katrina Evans
  • Leona Torosian
  • Anushka Silva
  • Craig Walsh
  • Kai Kessenbrock
  • Sci Immunol.2020 02;5(44). eaay6017. doi: 10.1126/sciimmunol.aay6017.

異化分業は、工学的共培養システムにおけるグルコース-キシロース混合物からのD-乳酸およびコハク酸の生産を向上させる

Catabolic Division of Labor Enhances Production of D-Lactate and Succinate From Glucose-Xylose Mixtures in Engineered Co-culture Systems.
  • Andrew D Flores
  • Hyun G Choi
  • Rodrigo Martinez
  • Moses Onyeabor
  • E Zeynep Ayla
  • Amanda Godar
  • Michael Machas
  • David R Nielsen
  • Xuan Wang
  • Front Bioeng Biotechnol.2020;8:329. doi: 10.3389/fbioe.2020.00329.Epub 2020-05-05.

赤血球AE1/バンド3トランスポートが優性遠位性腎性尿細管アシドーシス患者に認められた

Red Blood Cell AE1/Band 3 Transports in Dominant Distal Renal Tubular Acidosis Patients.
  • Jean-Philippe Bertocchio
  • Sandrine Genetet
  • Lydie Da Costa
  • Stephen B Walsh
  • Bertrand Knebelmann
  • Julie Galimand
  • Lucie Bessenay
  • Corinne Guitton
  • Renaud De Lafaille
  • Rosa Vargas-Poussou
  • Dominique Eladari
  • Isabelle Mouro-Chanteloup
  • Kidney Int Rep.2020 Mar;5(3):348-357. S2468-0249(20)30007-3. doi: 10.1016/j.ekir.2019.12.020.Epub 2020-01-13.

2番染色体2p11.2での再発性微小欠失は、胸腺低形成とDiGeorge症候群に類似した特徴と関連している

Recurrent microdeletions at chromosome 2p11.2 are associated with thymic hypoplasia and features resembling DiGeorge syndrome.
  • Joshua D Bernstock
  • Arthur H Totten
  • Abdel G Elkahloun
  • Kory R Johnson
  • Anna C Hurst
  • Frederick Goldman
  • Andrew K Groves
  • Fady M Mikhail
  • T Prescott Atkinson
  • J. Allergy Clin. Immunol..2020 Jan;145(1):358-367.e2. S0091-6749(19)31256-4. doi: 10.1016/j.jaci.2019.09.020.Epub 2019-10-07.

高分解能質量分析法によるAverrhoa carambola L.樹皮中の二次代謝物の同定とα-グルコシダーゼ、チロシナーゼ、エラスターゼ、抗酸化力の評価

Identification of secondary metabolites in Averrhoa carambola L. bark by high-resolution mass spectrometry and evaluation for α-glucosidase, tyrosinase, elastase, and antioxidant potential.
  • Syful Islam
  • Md Badrul Alam
  • Arif Ahmed
  • Seulgidaun Lee
  • Sang-Han Lee
  • Sunghwan Kim
  • Food Chem.2020 Jun;332:127377. S0308-8146(20)31239-5. doi: 10.1016/j.foodchem.2020.127377.Epub 2020-06-23.

HIV-1サブタイプC逆転写酵素阻害のための天然物スクリーニングのためのシュードウイルスアッセイ法の開発と評価

Development of a pseudovirus assay and evaluation to screen natural products for inhibition of HIV-1 subtype C reverse transcriptase.
  • Lufuno Grace Mavhandu
  • Hua Cheng
  • Yeou-Cheng Bor
  • Denis Manga Tebit
  • Marie-Louise Hammarskjold
  • David Rekosh
  • Pascal Obong Bessong
  • J Ethnopharmacol.2020 Aug;258:112931. S0378-8741(20)30780-7. doi: 10.1016/j.jep.2020.112931.Epub 2020-04-30.

ブラジル,サンパウロの大規模総合病院における定期的なカルテ監査の評価者間の一致度をプロスペクティブに評価したもの.

A prospective evaluation of inter-rater agreement of routine medical records audits at a large general hospital in São Paulo, Brazil.
  • Ana Carolina Cintra Nunes Mafra
  • João Luiz Miraglia
  • Fernando Antonio Basile Colugnati
  • Gilberto Soares Lourenço Padilha
  • Renata Rafaella Santos Tadeucci
  • Ederson Almeida
  • Mario Maia Bracco
  • BMC Health Serv Res.2020 Jul;20(1):638. 10.1186/s12913-020-05495-w. doi: 10.1186/s12913-020-05495-w.Epub 2020-07-10.

菱形脳シナプス症、三叉神経節の突発性および視細胞腫(脱毛症を伴わない)を呈した小児:小脳三叉神経皮膚異形成症の一変か?

A child with rhombencephalosynapsis, agenesis of the trigeminal ganglion and optic coloboma (without alopecia): a variant of the cerebellotrigeminal dermal dysplasia?
  • Federica Sullo
  • Stefano Palmucci
  • Agata Polizzi
  • Martino Ruggieri
  • Andrea D Praticò
  • Clin. Dysmorphol..2020 Jul;doi: 10.1097/MCD.0000000000000333.Epub 2020-07-10.

Klf9 は、グルココルチコイド受容体活性に対するトランスクリプトーム応答を制御する重要なフィードフォワード制御因子である

Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity.
  • Ian Gans
  • Ellen I Hartig
  • Shusen Zhu
  • Andrea R Tilden
  • Lucie N Hutchins
  • Nathaniel J Maki
  • Joel H Graber
  • James A Coffman
  • Sci Rep.2020 Jul;10(1):11415. 10.1038/s41598-020-68040-z. doi: 10.1038/s41598-020-68040-z.Epub 2020-07-10.

QbD(Quality by Design)アプローチを用いたリバスチグミンを搭載したナノ構造脂質キャリア(NLC)の鼻から脳への送達のための二重最適化。配合変数と機器パラメータ

Double Optimization of Rivastigmine-Loaded Nanostructured Lipid Carriers (NLC) for Nose-to-Brain Delivery Using the Quality by Design (QbD) Approach: Formulation Variables and Instrumental Parameters.
  • Sara Cunha
  • Cláudia Pina Costa
  • Joana A Loureiro
  • Jorge Alves
  • Andreia F Peixoto
  • Ben Forbes
  • José Manuel Sousa Lobo
  • Ana Catarina Silva
  • Pharmaceutics.2020 Jun;12(7). E599. doi: 10.3390/pharmaceutics12070599.Epub 2020-06-28.

鉄硫黄クラスター生合成タンパク質HSCBの変異は、先天性唾液性貧血の原因となる

Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia.
  • Andrew Crispin
  • Chaoshe Guo
  • Caiyong Chen
  • Dean R Campagna
  • Paul J Schmidt
  • Daniel A Lichtenstein
  • Chang Cao
  • Anoop K Sendamarai
  • Gordon J Hildick-Smith
  • Nicholas C Huston
  • Jeanne Boudreaux
  • Sylvia S Bottomley
  • Matthew M Heeney
  • Barry H Paw
  • Mark D Fleming
  • Sarah Ducamp
  • J. Clin. Invest..2020 Jul;135479. doi: 10.1172/JCI135479.Epub 2020-07-07.

HRAS遺伝子変異を有する前治療歴のある転移性尿路粘膜癌患者を対象としたティピファルニブの第II相試験

A phase II trial of tipifarnib for patients with previously-treated, metastatic urothelial carcinoma harboring HRAS mutations.
  • Hye Won Lee
  • Jason Kyungha Sa
  • Antonio Gualberto
  • Catherine Scholz
  • Hyun Hwan Sung
  • Byong Chang Jeong
  • Han Yong Choi
  • Ghee Young Kwon
  • Se Hoon Park
  • Clin. Cancer Res..2020 Jul;clincanres.1246.2020. doi: 10.1158/1078-0432.CCR-20-1246.Epub 2020-07-07.

"若い妊娠中の少女として...あなたが直面する課題"南アフリカの思春期の少女と若い女性の間のメンタルヘルスと性とリプロダクティブヘルスの交錯を探る

"As a Young Pregnant Girl… The Challenges You Face": Exploring the Intersection Between Mental Health and Sexual and Reproductive Health Amongst Adolescent Girls and Young Women in South Africa.
  • Zoe Duby
  • Tracy McClinton Appollis
  • Kim Jonas
  • Kealeboga Maruping
  • Janan Dietrich
  • Ashleigh LoVette
  • Caroline Kuo
  • Lieve Vanleeuw
  • Catherine Mathews
  • AIDS Behav.2020 Jul;10.1007/s10461-020-02974-3. doi: 10.1007/s10461-020-02974-3.Epub 2020-07-18.

小児多発性硬化症患者におけるリンパ球数の時間的プロファイルとフィンゴリモド療法による感染症との関連。PARADIG試験の結果

Temporal profile of lymphocyte counts and relationship with infections with fingolimod therapy in paediatric patients with multiple sclerosis: Results from the PARADIG study.
  • Tanuja Chitnis
  • Brenda Banwell
  • Lauren Krupp
  • Douglas L Arnold
  • Amit Bar-Or
  • Wolfgang Brück
  • Gavin Giovannoni
  • Benjamin Greenberg
  • Angelo Ghezzi
  • Emmanuelle Waubant
  • Kevin Rostasy
  • Kumaran Deiva
  • Peter Huppke
  • Jerry S Wolinsky
  • Ying Zhang
  • Amin Azmon
  • Annik K-Laflamme
  • Rajesh Karan
  • Jutta Gärtner
  • Mult. Scler..2020 Jul;:1352458520936934. doi: 10.1177/1352458520936934.Epub 2020-07-07.

腰椎椎椎間板ヘルニアの治療における経皮的内視鏡的腰椎椎椎間板切除術と開放的腰椎微小椎間板切除術の転帰の比較:2年間のレトロスペクティブコホート研究

A matched comparison of outcomes between percutaneous endoscopic lumbar discectomy and open lumbar microdiscectomy for the treatment of lumbar disc herniation: a two-year retrospective cohort study.
  • Meshal Jarebi
  • Aisha Awaf
  • Johann Peltier
  • Michel Lefranc
  • Spine J.2020 Jul;S1529-9430(20)30960-8. doi: 10.1016/j.spinee.2020.07.005.Epub 2020-07-16.

臨床評価カテゴリーと放射線学的特徴を用いたマルチパラメトリックMRIを用いた末梢部の臨床的に重要な前立腺癌を予測するための機械学習アルゴリズムの比較

Comparison of machine learning algorithms to predict clinically significant prostate cancer of the peripheral zone with multiparametric MRI using clinical assessment categories and radiomic features.
  • Simon Bernatz
  • Jörg Ackermann
  • Philipp Mandel
  • Benjamin Kaltenbach
  • Yauheniya Zhdanovich
  • Patrick N Harter
  • Claudia Döring
  • Renate Hammerstingl
  • Boris Bodelle
  • Kevin Smith
  • Andreas Bucher
  • Moritz Albrecht
  • Nicolas Rosbach
  • Lajos Basten
  • Ibrahim Yel
  • Mike Wenzel
  • Katrin Bankov
  • Ina Koch
  • Felix K-H Chun
  • Jens Köllermann
  • Peter J Wild
  • Thomas J Vogl
  • Eur Radiol.2020 Jul;10.1007/s00330-020-07064-5. doi: 10.1007/s00330-020-07064-5.Epub 2020-07-16.

大腸がん患者におけるイレオストミー閉鎖後の手術部位感染に対する陰圧創傷治療の評価:前向き多施設試験

Evaluation of negative-pressure wound therapy for surgical site infections after ileostomy closure in colorectal cancer patients: a prospective multicenter study.
  • Koichi Okuya
  • Ichiro Takemasa
  • Tetsuhiro Tsuruma
  • Ai Noda
  • Kenichi Sasaki
  • Tomomi Ueki
  • Mitsuhiro Mukaiya
  • Keita Saito
  • Kenji Okita
  • Toshihiko Nishidate
  • Emi Akizuki
  • Atsushi Hamabe
  • Masayuki Ishii
  • Surg. Today.2020 Jul;10.1007/s00595-020-02068-6. doi: 10.1007/s00595-020-02068-6.Epub 2020-07-07.

正方かごめ格子反強磁性体中のギャップレススピン液体

Gapless spin liquid in a square-kagome lattice antiferromagnet.
  • Masayoshi Fujihala
  • Katsuhiro Morita
  • Richard Mole
  • Setsuo Mitsuda
  • Takami Tohyama
  • Shin-Ichiro Yano
  • Dehong Yu
  • Shigetoshi Sota
  • Tomohiko Kuwai
  • Akihiro Koda
  • Hirotaka Okabe
  • Hua Lee
  • Shinichi Itoh
  • Takafumi Hawai
  • Takatsugu Masuda
  • Hajime Sagayama
  • Akira Matsuo
  • Koichi Kindo
  • Seiko Ohira-Kawamura
  • Kenji Nakajima
  • Nat Commun.2020 Jul;11(1):3429. 10.1038/s41467-020-17235-z. doi: 10.1038/s41467-020-17235-z.Epub 2020-07-09.

高齢者向けオンライン・ソーシャル・サポート・プラットフォーム設計のためのユーザー中心アプローチ:ユーザーのタイプと要件の特定

User-Centred Approach to Design an Online Social Support Platform for Seniors : Identification of Users' Types and Their Requirements.
  • Arnaud Ricci
  • Jessica Rochat
  • Henk Herman Nap
  • Lotte Cornelisse
  • Christian Lovis
  • Frédéric Ehrler
  • Stud Health Technol Inform.2020 Jun;270:1081-1085. SHTI200328. doi: 10.3233/SHTI200328.

HARS1の二項対立変異は、ヒスチジルtRNA合成酵素の発現と酵素活性を著しく低下させ、新規の多系統運動失調症候群を引き起こす

Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multisystem ataxic syndrome.
  • Daniele Galatolo
  • Molly E Kuo
  • Patrick Mullen
  • Rebecca Meyer-Schuman
  • Stefano Doccini
  • Roberta Battini
  • Maria Lieto
  • Alessandra Tessa
  • Alessandro Filla
  • Christopher Francklyn
  • Anthony Antonellis
  • Filippo M Santorelli
  • Hum. Mutat..2020 Jul;41(7):1232-1237. doi: 10.1002/humu.24024.Epub 2020-04-29.

組換えスパイク蛋白質のワクチン接種によるラマにおける中東呼吸器症候群コロナウイルス(MERS-CoV)の感染をブロックする

Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein.
  • Jordi Rodon
  • Nisreen M A Okba
  • Nigeer Te
  • Brenda van Dieren
  • Berend-Jan Bosch
  • Albert Bensaid
  • Joaquim Segalés
  • Bart L Haagmans
  • Júlia Vergara-Alert
  • Emerg Microbes Infect.2019;8(1):1593-1603. doi: 10.1080/22221751.2019.1685912.

ソフォスブビルは肝細胞におけるEGFR依存性経路を活性化し、肝関連の病理学的プロセスに影響を及ぼすことが示唆された

Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes.
  • Denisa Bojkova
  • Sandra Westhaus
  • Rui Costa
  • Lejla Timmer
  • Nora Funkenberg
  • Marek Korencak
  • Hendrik Streeck
  • Florian Vondran
  • Ruth Broering
  • Stefan Heinrichs
  • Karl S Lang
  • Sandra Ciesek
  • Cells.2020 Apr;9(4). E1003. doi: 10.3390/cells9041003.Epub 2020-04-17.

南イタリアの非成人の認知健康。卓越した長寿の横断的、家庭ベースのパイロット研究(Cilento Initiative on Aging Outcomes or CIAO)からの記述的分析

Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).
  • Vincenzo Pizza
  • Paola Antonini
  • Rosella Marino
  • Giovanni D'Arena
  • Serena Grazia Lucibello
  • Marianna Rizzo
  • David A Brenner
  • Dilip V Jeste
  • Salvatore Di Somma
  • Medicina (Kaunas).2020 May;56(5). E218. doi: 10.3390/medicina56050218.Epub 2020-05-05.

Achillea abrotanoides (Vis.) Vis.からの新しいロンギピナンケトン:精油の化学変換により、マイナーな成分の同定が可能になった

A new longipinane ketone from Achillea abrotanoides (Vis.) Vis.: chemical transformation of the essential oil enables the identification of a minor constituent.
  • Niko S Radulović
  • Marko Z Mladenović
  • Milenko N Ristić
  • Vidoslav S Dekić
  • Biljana R Dekić
  • Novica R Ristić
  • Phytochem Anal.2020 Jul;31(4):501-515. doi: 10.1002/pca.2913.Epub 2020-01-24.