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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

マダニ(Haemaphysalis longicornis)に咬まれた際の宿主皮膚におけるタンパク質発現レベルとリン酸化レベルの包括的な解析

Comprehensive analysis of protein expression levels and phosphorylation levels in host skin in response to tick (Haemaphysalis longicornis) bite.
  • Xiaoli Zhang
  • Baowen Zhang
  • Abolfazl Masoudi
  • Xiaoshuang Wang
  • Xiaomin Xue
  • Mengxue Li
  • Qi Xiao
  • Minjing Wang
  • Jingze Liu
  • Hui Wang
  • J Proteomics.2020 Jul;:103898. S1874-3919(20)30266-9. doi: 10.1016/j.jprot.2020.103898.Epub 2020-07-15.

研究パートナーとして患者を参加させることは、コミュニケーション・スキル研修プログラム(KOKOS-Rheuma)の開発と評価に例示されている

Involving patients as research partners exemplified by the development and evaluation of a communication-skills training programme (KOKOS-Rheuma).
  • A C Schöpf-Lazzarino
  • P Böhm
  • U Garske
  • M Schlöffel
  • A Stoye
  • J Lamprecht
  • W Mau
  • E Farin
  • Z Rheumatol.2020 Jul;10.1007/s00393-020-00839-7. doi: 10.1007/s00393-020-00839-7.Epub 2020-07-16.

Covid-19入院前のICu患者における免疫調節薬の再利用-mulTi-Arm治療試験-再利用薬(TACTIC-R)を用いたCovid-19入院前のICu患者を対象とした試験。無作為化比較試験の試験計画書の構造化された要約

Repurposed immunomodulatory drugs for Covid-19 in pre-ICu patients - mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19 - Repurposed Drugs (TACTIC-R): A structured summary of a study protocol for a randomised controlled trial.
  • Spoorthy Kulkarni
  • Marie Fisk
  • Michalis Kostapanos
  • Edward Banham-Hall
  • Simon Bond
  • Elena Hernan-Sancho
  • Sam Norton
  • Joseph Cheriyan
  • Andrew Cope
  • James Galloway
  • Frances Hall
  • David Jayne
  • Ian B Wilkinson
  • Trials.2020 Jul;21(1):626. 10.1186/s13063-020-04535-4. doi: 10.1186/s13063-020-04535-4.Epub 2020-07-08.

血行動態的に有意な冠動脈疾患診断のためのストレスダイナミック心筋CT灌流の心筋血流解析。相対パラメータ最適化の臨床的価値

Myocardial blood flow analysis of stress dynamic myocardial CT perfusion for hemodynamically significant coronary artery disease diagnosis: The clinical value of relative parameter optimization.
  • Yan Yi
  • Cheng Xu
  • Wei Wu
  • Yun Wang
  • Yu-Mei Li
  • Zhu-Jun Shen
  • Zheng-Yu Jin
  • Yi-Ning Wang
  • J Cardiovasc Comput Tomogr.2019 Oct;S1934-5925(19)30173-X. doi: 10.1016/j.jcct.2019.10.001.Epub 2019-10-10.

個人用保護具が病院前提供者による小児救急処置のパフォーマンスに与える影響

Impact of Personal Protective Equipment on the Performance of Emergency Pediatric Procedures by Prehospital Providers.
  • Maybelle Kou
  • Aaron J Donoghue
  • Helen Stacks
  • Adam Kochman
  • Meghan Semiao
  • Mark Nash
  • David Siegel
  • Lawrence Ku
  • Julie Debski
  • Jia-Yuh Chen
  • Gaurav Sharma
  • Leigh Gosnell
  • Steven Krug
  • Mark D Adler
  • Disaster Med Public Health Prep.2020 May;:1-21. S1935789320001287. doi: 10.1017/dmp.2020.128.Epub 2020-05-11.

ルイス酸触媒によるプロパルギルアルコールと(E)-3-アミノ-3-フェニルアクリロニトリルのアニュレーションを介した1,6-ジヒドロピリジン-3-カルボニトリル誘導体の合成

Synthesis of 1,6-Dihydropyridine-3-carbonitrile Derivatives via Lewis Acid-Catalyzed Annulation of Propargylic Alcohols with (E)-3-amino-3-phenylacrylonitriles.
  • Li-Juan Du
  • Yuecheng Zhang
  • Hong-Yu Zhang
  • Guohui Yin
  • Xiao-Yan Wang
  • Jiquan Zhao
  • Ya-Ping Han
  • J. Org. Chem..2020 Jul;doi: 10.1021/acs.joc.0c01171.Epub 2020-07-15.

抗生物質デリバリービークル(ADV)としてのナノ粒子は、MRSAおよび他のMDR細菌病原体による耐性を克服する:手榴弾仮説

Nanoparticles as antibiotic-delivery vehicles (ADVs) overcome resistance by MRSA and other MDR bacterial pathogens: the grenade hypothesis.
  • Amjed Alabresm
  • Yung Pin Chen
  • Savannah Wichter-Chandler
  • Jamie Lead
  • Brian C Benicewicz
  • Alan W Decho
  • J Glob Antimicrob Resist.2020 Jul;S2213-7165(20)30168-5. doi: 10.1016/j.jgar.2020.06.023.Epub 2020-07-09.

RobotiX Mentorバーチャルリアリティシミュレーションプラットフォーム上でのロボット手術の基礎(FRS)カリキュラムの有効性を実証する

Demonstrating the effectiveness of the fundamentals of robotic surgery (FRS) curriculum on the RobotiX Mentor Virtual Reality Simulation Platform.
  • John Rhodes Martin
  • Dimitrios Stefanidis
  • Ryan P Dorin
  • Alvin C Goh
  • Richard M Satava
  • Jeffrey S Levy
  • J Robot Surg.2020 May;10.1007/s11701-020-01085-4. doi: 10.1007/s11701-020-01085-4.Epub 2020-05-14.

大豆粕の熱機械的および酵素促進処理は、離乳期の豚における試験管内でのタンパク質消化速度とタンパク質および アミノ酸消化率を向上させた

Thermo-mechanical and enzyme-facilitated processing of soybean meal enhanced in vitro kinetics of protein digestion and protein and amino acid digestibility in weaned pigs.
  • Mai Anh Ton Nu
  • Ingrid Lupatsch
  • Joaquin S Zannatta
  • Hagen Schulze
  • Ruurd T Zijlstra
  • J. Anim. Sci..2020 Jul;skaa224. doi: 10.1093/jas/skaa224.Epub 2020-07-16.

フコイダンを精製したフコイダンは、UVB誘発ヒト角化細胞において、光酸化ストレスと皮膚バリア障害を抑制する保護効果があることを示した

Fucoidan refined by Sargassum confusum indicate protective effects suppressing photo-oxidative stress and skin barrier perturbation in UVB-induced human keratinocytes.
  • Ilekuttige Priyan Shanura Fernando
  • Mawalle Kankanamge Hasitha Madhawa Dias
  • Disanayake Mudiyanselage Dinesh Madusanka
  • Eui Jeong Han
  • Min Ju Kim
  • You-Jin Jeon
  • Ginnae Ahn
  • Int. J. Biol. Macromol..2020 Jul;S0141-8130(20)33890-3. doi: 10.1016/j.ijbiomac.2020.07.136.Epub 2020-07-15.

グアノシンは軽度外傷性脳損傷後の行動およびミトコンドリアの生体エネルギー変化に対して保護する

Guanosine Protects Against Behavioural and Mitochondrial Bioenergetic Alterations after Mild Traumatic Brain Injury.
  • Aline Alves Courtes
  • Débora Farina Gonçalves
  • Diane Duarte Hartmann
  • Pamela Carvalho da Rosa
  • Gustavo Cassol
  • Luiz Fernando Freire Royes
  • Nelson Rodrigues de Carvalho
  • Félix Alexandre Antunes Soares
  • Brain Res. Bull..2020 Jul;S0361-9230(20)30550-5. doi: 10.1016/j.brainresbull.2020.07.003.Epub 2020-07-15.

いくつかの腫瘍由来の細胞株に対する葉エタノール抽出物およびイヌインターフェロンとの組み合わせの抗増殖活性

antiproliferation activity of leaves ethanol extract and its combination with canine interferons on several tumor-derived cell lines.
  • Bambang Pontjo Priosoeryanto
  • Riski Rostantinata
  • Eva Harlina
  • Waras Nurcholis
  • Rachmi Ridho
  • Lina Noviyanti Sutardi
  • Vet World.2020 May;13(5):931-939. Vetworld-13-931. doi: 10.14202/vetworld.2020.931-939.Epub 2020-05-19.

冠動脈疾患の中等度または高リスクの症候性患者に対するストレスダイナミック心筋CT灌流。絶対心筋血流解析と相対心筋血流解析の最適化と増分改善

Stress dynamic myocardial CT perfusion for symptomatic patients with intermediate- or high-risk of coronary artery disease: Optimization and incremental improvement between the absolute and relative myocardial blood flow analysis.
  • Yan Yi
  • Cheng Xu
  • Wei Wu
  • Yun Wang
  • Yu-Mei Li
  • Ying-Qian Ge
  • Zhu-Jun Shen
  • Jia-Yin Zhang
  • Bin Lu
  • Zheng-Yu Jin
  • Yi-Ning Wang
  • J Cardiovasc Comput Tomogr.2020 Jan;S1934-5925(19)30582-9. doi: 10.1016/j.jcct.2020.01.010.Epub 2020-01-30.

多発性硬化症患者におけるヒト免疫不全ウイルス感染症の獲得:これらの状態はお互いの経過にポジティブな影響を与える可能性があるか?

Acquisition of human immunodeficiency virus infection in a patient with multiple sclerosis: could these conditions positively influence each other's course?
  • Ilaria Mainardi
  • Maria Teresa Ferrò
  • Matteo Gastaldi
  • Diego Franciotta
  • Paola Cinque
  • J. Neurovirol..2020 Jul;10.1007/s13365-020-00876-7. doi: 10.1007/s13365-020-00876-7.Epub 2020-07-15.

BMPシグナル伝達経路の阻害は、実験的自己免疫性脳脊髄炎の確立した臨床症状を改善した

Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis.
  • Herena Eixarch
  • Laura Calvo-Barreiro
  • Carme Costa
  • Gemma Reverter-Vives
  • Mireia Castillo
  • Vanessa Gil
  • José Antonio Del Río
  • Xavier Montalban
  • Carmen Espejo
  • Neurotherapeutics.2020 Jul;10.1007/s13311-020-00885-8. doi: 10.1007/s13311-020-00885-8.Epub 2020-07-17.

地下水に生息するエルシマイクロビアは、腸内細菌群のエルシマイクロビアに比べて代謝的に多様であり、一部のエルシマイクロビアは新規なニトロゲナーゼの類縁体を持っている

Groundwater Elusimicrobia are metabolically diverse compared to gut microbiome Elusimicrobia and some have a novel nitrogenase paralog.
  • Raphaël Méheust
  • Cindy J Castelle
  • Paula B Matheus Carnevali
  • Ibrahim F Farag
  • Christine He
  • Lin-Xing Chen
  • Yuki Amano
  • Laura A Hug
  • Jillian F Banfield
  • ISME J.2020 Jul;10.1038/s41396-020-0716-1. doi: 10.1038/s41396-020-0716-1.Epub 2020-07-17.

シングルセルRNA-seqとバルクRNA-seqの統合解析により、腫瘍の不均一性に加えて、TNBCにおけるM2様の腫瘍関連マクロファージ浸潤と攻撃性が解明された

Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and aggressiveness in TNBC.
  • Xuanwen Bao
  • Run Shi
  • Tianyu Zhao
  • Yanfang Wang
  • Natasa Anastasov
  • Michael Rosemann
  • Weijia Fang
  • Cancer Immunol. Immunother..2020 Jul;10.1007/s00262-020-02669-7. doi: 10.1007/s00262-020-02669-7.Epub 2020-07-17.

大腸がんの治療反応予測バイオマーカーとしての遺伝子多型と関連INDEL-個別化医療に向けて

gene polymorphisms and related indel as predictor biomarkers of treatment response for colorectal cancer - toward a personalized medicine.
  • Mouadh Barbirou
  • Ikram Sghaier
  • Sinda Bedoui
  • Rahma Ben Abderrazek
  • Hazar Kraiem
  • Azer Farah
  • Rym Hassiki
  • Amina Mokrani
  • Amel Mezlini
  • Wassim Y Almawi
  • Besma Loueslati-Yacoubi
  • Balkiss Bouhaouala-Zahar
  • Tumour Biol..2020 Jun;42(6):1010428320925237. doi: 10.1177/1010428320925237.

薬剤耐性強迫性障害(OCD)における rTMS 治療の有効性と臨床的予測因子:レトロスペクティブ研究

Efficacy and clinical predictors of response to rTMS treatment in pharmacoresistant obsessive-compulsive disorder (OCD): a retrospective study.
  • Reza Rostami
  • Reza Kazemi
  • Arezoo Jabbari
  • Azam Sadat Madani
  • Hosseinreza Rostami
  • Mohammad Amin Taherpour
  • Parviz Molavi
  • Nematollah Jaafari
  • Min-Fang Kuo
  • Carmelo M Vicario
  • Michael A Nitsche
  • Mohammad Ali Salehinejad
  • BMC Psychiatry.2020 Jul;20(1):372. 10.1186/s12888-020-02769-9. doi: 10.1186/s12888-020-02769-9.Epub 2020-07-16.

特異性タンパク質1のフレームシフト変異が、家族性骨髄不全におけるSp1介在転写のスーパーアクチベーションを誘発することを明らかにした

A frameshift variant in specificity protein 1 triggers superactivation of Sp1-mediated transcription in familial bone marrow failure.
  • Hemanth Tummala
  • Amanda J Walne
  • Findlay Bewicke-Copley
  • Alicia Ellison
  • Nikolas Pontikos
  • Maria G Bridger
  • Ana Rio-Machin
  • Jasmin K Sidhu
  • Jun Wang
  • Henrik Hasle
  • Jude Fitzgibbon
  • Tom Vulliamy
  • Inderjeet Dokal
  • Proc. Natl. Acad. Sci. U.S.A..2020 Jul;202002857. doi: 10.1073/pnas.2002857117.Epub 2020-07-07.

高所得国における社会経済的グループ間の室内空気汚染への曝露。文献のスコープレビューとモデル化の方法論

Exposure to indoor air pollution across socio-economic groups in high-income countries: A scoping review of the literature and a modelling methodology.
  • Lauren Ferguson
  • Jonathon Taylor
  • Michael Davies
  • Clive Shrubsole
  • Phil Symonds
  • Sani Dimitroulopoulou
  • Environ Int.2020 Jul;143:105748. S0160-4120(19)34091-7. doi: 10.1016/j.envint.2020.105748.Epub 2020-07-03.

Brd1発現の低下は、可逆的なうつ病様行動と遺伝子発現の変化をもたらす

Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.
  • Anto P Rajkumar
  • Per Qvist
  • Julie G Donskov
  • Ross Lazarus
  • Jonatan Pallesen
  • Nicoletta Nava
  • Gudrun Winther
  • Nico Liebenberg
  • Sanne H la Cour
  • Veerle Paternoster
  • Tue Fryland
  • Johan Palmfeldt
  • Kim Fejgin
  • Arne Mørk
  • Mette Nyegaard
  • Bente Pakkenberg
  • Michael Didriksen
  • Jens R Nyengaard
  • Gregers Wegener
  • Ole Mors
  • Jane H Christensen
  • Anders D Børglum
  • Transl Psychiatry.2020 Jul;10(1):239. 10.1038/s41398-020-00914-2. doi: 10.1038/s41398-020-00914-2.Epub 2020-07-17.

慢性腎臓病患者におけるクレアチニンとシスタチンCによる糸球体濾過率の不明確な傾向:KNOW-CKDコホートからの結果

Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort.
  • Eunjeong Kang
  • Seung Seok Han
  • Jayoun Kim
  • Sue Kyung Park
  • Wookyung Chung
  • Yun Kyu Oh
  • Dong-Wan Chae
  • Yong-Soo Kim
  • Curie Ahn
  • Kook-Hwan Oh
  • BMC Nephrol.2020 Jul;21(1):280. 10.1186/s12882-020-01932-4. doi: 10.1186/s12882-020-01932-4.Epub 2020-07-16.

COVID-19 パンデミック時の表皮水疱症の集学的ケア-コンセンサス。国際的な専門家パネルによる勧告

Multidisciplinary Care of Epidermolysis Bullosa during the COVID-19 Pandemic - Consensus: Recommendations by an International Panel of Experts.
  • Dedee F Murrell
  • Anne W Lucky
  • Julio C Salas-Alanis
  • David T Woodley
  • Francis Palisson
  • Ken Natsuga
  • Milos Nikolic
  • Mae Ramirez-Quizon
  • Amy S Paller
  • Irene Lara-Corrales
  • Mohammadreza Amir Barzegar
  • Eli Sprecher
  • Cristina Has
  • Martin Laimer
  • Anna L Bruckner
  • Asli Bilgic
  • Arti Nanda
  • Diana Purvis
  • Alain Hovnanian
  • Slobodna Murat-Sušić
  • Johannes Bauer
  • Johannes S Kern
  • Christine Bodemer
  • Linda K Martin
  • Jemima Mellerio
  • Cezary Kowaleski
  • Susan J Robertson
  • Leena Bruckner-Tuderman
  • Elena Pope
  • M Peter Marinkovich
  • Jean Y Tang
  • John Su
  • Jouni Uitto
  • Lawrence F Eichenfield
  • Joyce Teng
  • Mark Jean Aan Koh
  • Sang Eun Lee
  • Phuong Khuu
  • Heather I Rishel
  • Mette Sommerlund
  • Karen Wiss
  • Chao-Kai Hsu
  • Tor Wo Chiu
  • Anna E Martinez
  • J. Am. Acad. Dermatol..2020 Jul;S0190-9622(20)32195-2. doi: 10.1016/j.jaad.2020.06.1023.Epub 2020-07-15.

カタツムリはTOR依存的にエンドサイクリングを同期させ、ショウジョウバエの臨界体重チェックポイントの間にエンドレプリーションの一時停止からの進入と脱出を調整している

Snail synchronizes endocycling in a TOR-dependent manner to coordinate entry and escape from endoreplication pausing during the Drosophila critical weight checkpoint.
  • Jie Zeng
  • Nhan Huynh
  • Brian Phelps
  • Kirst King-Jones
  • PLoS Biol..2020 02;18(2):e3000609. PBIOLOGY-D-19-00191. doi: 10.1371/journal.pbio.3000609.Epub 2020-02-25.

オーストラリアの入院患者の精神保健サービスにおける、攻撃性、自傷行為、性的危害、逃亡などの懸念行動の調査

Exploring behaviours of concern including aggression, self-harm, sexual harm and absconding within an Australian inpatient mental health service.
  • Matthew Kang
  • Hannah Bushell
  • Stuart Lee
  • Caitlin Berry
  • Yitzchak Hollander
  • Ilan Rauchberger
  • Fiona Whitecross
  • Australas Psychiatry.2020 Jun;:1039856220926940. doi: 10.1177/1039856220926940.Epub 2020-06-02.

殺虫性スズメバチ毒素Γ-ポンピリドトキシンは、電位依存性ナトリウムチャネルを調節する線形ペプチドである

The insecticidal wasp toxin Γ-Pompilidotoxin is a linear peptide modulating voltage-gated sodium channels.
  • Steve Peigneur
  • Andrey V Tsarev
  • Alexander S Paramonov
  • Christina I Schroeder
  • Maria P Ikonomopoulou
  • Hidetoshi Inagaki
  • David J Craik
  • Katsuhiro Konno
  • Zakhar O Shenkarev
  • Jan Tytgat
  • Toxicon.2020 Apr;177 Suppl 1:S40. S0041-0101(19)30831-1. doi: 10.1016/j.toxicon.2019.12.069.

カフェイン摂取が確認された早産児を持つ妊婦のコホートにおけるCYP2E1代謝活性の変調

Modulation of CYP2E1 metabolic activity in a cohort of confirmed caffeine ingesting pregnant women with preterm offspring.
  • M R Alcorta-García
  • C N López-Villaseñor
  • G Sánchez-Ferrer
  • H Flores-Mendoza
  • F Castorena-Torres
  • M A Aguilar-Torres
  • C M Sepúlveda-Treviño
  • J A Hernández-Hernández
  • R C López-Sánchez
  • V J Lara-Díaz
  • Mol Cell Pediatr.2020 Jun;7(1):4. 10.1186/s40348-020-00096-3. doi: 10.1186/s40348-020-00096-3.Epub 2020-06-01.

クラドリビンはATF4を介したアポトーシスを誘導し、びまん性大細胞型B細胞リンパ腫細胞においてSAHAと相乗的に作用します

Cladribine Induces ATF4 Mediated Apoptosis and Synergizes with SAHA in Diffuse Large B-Cell Lymphoma Cells.
  • Linyan Xu
  • Jun Jiao
  • Xiaoshen Sun
  • Wei Sang
  • Xiang Gao
  • Pu Yang
  • Dongmei Yan
  • Xuguang Song
  • Cai Sun
  • Mengdi Liu
  • Yuanyuan Qin
  • Yu Tian
  • Feng Zhu
  • Lingyu Zeng
  • Zhenyu Li
  • Kailin Xu
  • Int J Med Sci.2020;17(10):1375-1384. ijmsv17p1375. doi: 10.7150/ijms.41793.Epub 2020-05-30.

限界ヒト腎臓の生体外再生のための冷蔵保存による微小血管閉塞の溶解

Lysis of cold-storage-induced microvascular obstructions for ex vivo revitalization of marginal human kidneys.
  • Jenna R DiRito
  • Sarah A Hosgood
  • Melanie Reschke
  • Claire Albert
  • Laura G Bracaglia
  • John R Ferdinand
  • Benjamin J Stewart
  • Christopher M Edwards
  • Anand G Vaish
  • Sathia Thiru
  • David C Mulligan
  • Danielle J Haakinson
  • Menna R Clatworthy
  • W Mark Saltzman
  • Jordan S Pober
  • Michael L Nicholson
  • Gregory T Tietjen
  • Am. J. Transplant..2020 Jul;doi: 10.1111/ajt.16148.Epub 2020-07-05.

TBX5 R264KはT-box経路とは独立してマウスの拡張型心筋症発症の修飾因子として作用する

TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway.
  • Nariaki Miyao
  • Yukiko Hata
  • Hironori Izumi
  • Ryo Nagaoka
  • Yuko Oku
  • Ichiro Takasaki
  • Taisuke Ishikawa
  • Shinya Takarada
  • Mako Okabe
  • Hideyuki Nakaoka
  • Keijiro Ibuki
  • Sayaka Ozawa
  • Tomoyuki Yoshida
  • Hideyuki Hasegawa
  • Naomasa Makita
  • Naoki Nishida
  • Hisashi Mori
  • Fukiko Ichida
  • Keiichi Hirono
  • PLoS ONE.2020;15(4):e0227393. PONE-D-19-34630. doi: 10.1371/journal.pone.0227393.Epub 2020-04-01.

局所進行性肝胆道悪性腫瘍に対する複雑な肝切除術への肝移植経験の移行性-単施設での 3 10 年間の経験から得られた教訓

Transferability of Liver Transplantation Experience to Complex Liver Resection for Locally Advanced Hepatobiliary Malignancy - Lessons Learnt From 3 Decades of Single Center Experience.
  • Albert C Y Chan
  • Kenneth S H Chok
  • Jeff Dai
  • Simon H Y Tsang
  • Tan To Cheung
  • Ronnie Poon
  • S T Fan
  • C M Lo
  • Ann. Surg..2020 Jul;doi: 10.1097/SLA.0000000000004227.Epub 2020-07-09.

ヤコン(Smallanthus sonchifolius)は、大腸発癌の動物モデルにおいて、炎症、酸化ストレス、腸内変化を抑制しました

Yacón (Smallanthus sonchifolius) prevented inflammation, oxidative stress, and intestinal alterations in an animal model of colorectal carcinogenesis.
  • Thaísa Agrizzi Verediano
  • Mirelle Lomar Viana
  • Maria das Graças Vaz Tostes
  • Daniela Silva de Oliveira
  • Louisiane de Carvalho Nunes
  • Neuza Maria Brunoro Costa
  • J. Sci. Food Agric..2020 Jun;doi: 10.1002/jsfa.10595.Epub 2020-06-21.

カルシウムチャネル遮断剤としてのカルコン誘導体の同定と検討ファーマコフォアモデリング、ドッキング試験、インビトロスクリーニング、3D-QSAR解析

Identification and Investigation of Chalcone Derivatives as Calcium Channel Blockers: Pharmacophore modeling, Docking studies, In-vitro screening, and 3D-QSAR Analysis.
  • Amol S Sherikar
  • Manish S Bhatia
  • Rakesh P Dhavale
  • Curr Comput Aided Drug Des.2020 Jul;CAD-EPUB-108170. doi: 10.2174/1573409916666200714143930.Epub 2020-07-14.

γ9δ2T細胞の多様性と腫瘍細胞との受容体インターフェース

γ9δ2T cell diversity and the receptor interface with tumor cells.
  • Anna Vyborova
  • Dennis X Beringer
  • Domenico Fasci
  • Froso Karaiskaki
  • Eline van Diest
  • Lovro Kramer
  • Aram de Haas
  • Jasper Sanders
  • Anke Janssen
  • Trudy Straetemans
  • Daniel Olive
  • Jeanette Hw Leusen
  • Lola Boutin
  • Steven Nedellec
  • Samantha L Schwartz
  • Michael J Wester
  • Keith A Lidke
  • Emmanuel Scotet
  • Diane Lidke
  • Albert Jr Heck
  • Zsolt Sebestyen
  • Jurgen Kuball
  • J. Clin. Invest..2020 Jun;132489. doi: 10.1172/JCI132489.Epub 2020-06-02.

心不全患者に対するカルベジロール治療におけるβ,β,α-およびα-アドレナリン受容体に対する自己抗体検出の臨床的有用性

Clinical value of detecting autoantibodies against β-, β,- and α-adrenergic receptors in carvedilol treatment of patients with heart failure.
  • Dong-Yan Hou
  • Lin Xu
  • Zhi-Yong Zhang
  • Xiao-Rong Xu
  • Xin Wang
  • Juan Zhang
  • Jia-Mei Liu
  • Hua Wang
  • Jin Chen
  • Lin Zhang
  • J Geriatr Cardiol.2020 Jun;17(6):305-312. jgc-17-06-305. doi: 10.11909/j.issn.1671-5411.2020.06.002.

深海生物ノーザンシュリンプ(Pandalus borealis)と冷水サンゴ(Lophelia pertusa)の石油関連芳香族化合物、分散媒、アラスカノーススロープ原油に対する感受性

The sensitivity of the deepsea species northern shrimp (Pandalus borealis) and the cold-water coral (Lophelia pertusa) to oil-associated aromatic compounds, dispersant, and Alaskan North Slope crude oil.
  • Jenny Bytingsvik
  • Thomas F Parkerton
  • Julien Guyomarch
  • Luca Tassara
  • Stephane LeFloch
  • W Ray Arnold
  • Susanne M Brander
  • Aswani Volety
  • Lionel Camus
  • Mar. Pollut. Bull..2020 Jul;156:111202. S0025-326X(20)30320-9. doi: 10.1016/j.marpolbul.2020.111202.Epub 2020-05-17.

Flk2/Flt3を発現するCD34+CD38-単細胞から増殖させたクローン細胞による非肥満糖尿病/重症複合免疫不全マウスにおけるヒト造血の再構築

Reconstitution of human haematopoiesis in non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34+CD38- cells expressing Flk2/Flt3.
  • Yasuhiro Ebihara
  • Mika Wada
  • Takahiro Ueda
  • Ming-Jiang Xu
  • Atsushi Manabe
  • Ryuhei Tanaka
  • Mamoru Ito
  • Hideo Mugishima
  • Shigetaka Asano
  • Tatsutoshi Nakahata
  • Kohichiro Tsuji
  • Br. J. Haematol..2002 Nov;119(2):525-34. 3820. doi: 10.1046/j.1365-2141.2002.03820.x.

周辺環境への新興有機汚染物質の発生源としての埋立地浸出液のリスク評価と調査:中国済南市最大の埋立地のケーススタディ

Risk assessment and investigation of landfill leachate as a source of emerging organic contaminants to the surrounding environment: a case study of the largest landfill in Jinan City, China.
  • Kun Wang
  • Febelyn Reguyal
  • Tao Zhuang
  • Environ Sci Pollut Res Int.2020 Jul;10.1007/s11356-020-10093-8. doi: 10.1007/s11356-020-10093-8.Epub 2020-07-17.

ALG13 欠損症の 29 例の個体における優勢型および新規 de novo バリアント。臨床的記述、バイオマーカーの状態、生化学的分析と治療の提案

Predominant and novel de novo variants in 29 individuals with ALG13 deficiency: Clinical description, biomarker status, biochemical analysis and treatment suggestions.
  • Bobby G Ng
  • Erik A Eklund
  • Sergey A Shiryaev
  • Yin Y Dong
  • Mary-Alice Abbott
  • Carla Asteggiano
  • Michael J Bamshad
  • Eileen Barr
  • Jonathan A Bernstein
  • Shabeed Chelakkadan
  • John Christodoulou
  • Wendy K Chung
  • Michael A Ciliberto
  • Janice Cousin
  • Fiona Gardiner
  • Suman Ghosh
  • William D Graf
  • Stephanie Grunewald
  • Katherine Hammond
  • Natalie S Hauser
  • George E Hoganson
  • Kimberly M Houck
  • Jennefer N Kohler
  • Eva Morava
  • Austin A Larson
  • Pengfei Liu
  • Sujana Madathil
  • Colleen McCormack
  • Naomi J L Meeks
  • Rebecca Miller
  • Kristin G Monaghan
  • Deborah A Nickerson
  • Timothy Blake Palculict
  • Gabriela Magali Papazoglu
  • Beth A Pletcher
  • Ingrid E Scheffer
  • Andrea Beatriz Schenone
  • Rhonda E Schnur
  • Yue Si
  • Leah J Rowe
  • Alvaro H Serrano Russi
  • Rossana Sanchez Russo
  • Farouq Thabet
  • Allysa Tuite
  • María Mercedes Villanueva
  • Raymond Y Wang
  • Richard I Webster
  • Dorcas Wilson
  • Alice Zalan
  • Undiagnosed Diseases Network
  • Lynne A Wolfe
  • Jill A Rosenfeld
  • Lindsay Rhodes
  • Hudson H Freeze
  • J. Inherit. Metab. Dis..2020 Jul;doi: 10.1002/jimd.12290.Epub 2020-07-18.

1,2-ジメチルヒドラジンに対する肝臓および結腸の亜急性反応に関連する初期の分子イベント。肝臓と大腸の亜急性反応に関連する初期の分子イベント:前腫瘍性病変および新腫瘍性病変の発生に関する潜在的な意味合い

Early molecular events associated with liver and colon sub-acute responses to 1,2-dimethylhydrazine: Potential implications on preneoplastic and neoplastic lesion development.
  • Brunno Felipe Ramos Caetano
  • Mariana Baptista Tablas
  • Guilherme Ribeiro Romualdo
  • Maria Aparecida Marchesan Rodrigues
  • Luís Fernando Barbisan
  • Toxicol. Lett..2020 Sep;329:67-79. S0378-4274(20)30114-4. doi: 10.1016/j.toxlet.2020.04.009.Epub 2020-05-06.

カルバクロールの降圧効果は、ドラッグデリバリーシステムとしてβ-シクロデキストリンに組み込むことで改善される

Antihypertensive effect of carvacrol is improved after incorporation in β-cyclodextrin as a drug delivery system.
  • Liliane Barreto
  • Samuel Barbosa Camargo
  • Raiana Dos Anjos Moraes
  • Carla Fiama Medeiros
  • Anderson de Melo Jesus
  • Afrânio Evangelista
  • Cristiane Flora Villarreal
  • Lucindo José Quintans-Júnior
  • Darízy Flávia Silva
  • Clin. Exp. Pharmacol. Physiol..2020 Jun;doi: 10.1111/1440-1681.13364.Epub 2020-06-22.

メロン/ワタアブラムシ(Aphis gossypii Glover)のジノテフランに対する代謝抵抗性には、CYP6CY14、CYP6CY22、CYP6UN1の3つのチトクロームP450遺伝子の過剰発現が関与していることが明らかになった

The overexpression of three cytochrome P450 genes CYP6CY14, CYP6CY22 and CYP6UN1 contributed to metabolic resistance to dinotefuran in melon/cotton aphid, Aphis gossypii Glover.
  • Anqi Chen
  • Huihui Zhang
  • Tisheng Shan
  • Xueyan Shi
  • Xiwu Gao
  • Pestic Biochem Physiol.2020 Jul;167:104601. S0048-3575(20)30096-1. doi: 10.1016/j.pestbp.2020.104601.Epub 2020-05-11.

大気中のCs・I/Cs観測データと大気輸送・沈着モデルのマルチアンサンブルに基づく福島原発事故による初期I吸入線量の再評価

Reassessment of early I inhalation doses by the Fukushima nuclear accident based on atmospheric Cs and I/Cs observation data and multi-ensemble of atmospheric transport and deposition models.
  • Mai Takagi
  • Toshimasa Ohara
  • Daisuke Goto
  • Yu Morino
  • Junya Uchida
  • Tsuyoshi Thomas Sekiyama
  • Shoji F Nakayama
  • Mitsuru Ebihara
  • Yasuji Oura
  • Teruyuki Nakajima
  • Haruo Tsuruta
  • Yuichi Moriguchi
  • J Environ Radioact.2020 Jul;218:106233. S0265-931X(19)30992-0. doi: 10.1016/j.jenvrad.2020.106233.Epub 2020-03-17.

疫学における多様性、包摂性、代表性、参加性を向上させるための機会が豊富に存在する。現在のアプローチでは不十分なので、より多くの情報に基づいた行動が必要である

A Smorgasbord of Opportunities Exist to Improve Diversity, Inclusion, Representation, and Participation in Epidemiology: More Informed Action is Necessary Since Current Approaches are Insufficient.
  • Chandra L Jackson
  • Am. J. Epidemiol..2020 Jun;kwaa104. doi: 10.1093/aje/kwaa104.Epub 2020-06-30.

焼失性口内症候群患者884人における貧血、血行不良、高ホモシステイン血症、および血清胃頭頂細胞抗体陽性

Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in 884 patients with burning mouth syndrome.
  • Chun-Pin Chiang
  • Yu-Hsueh Wu
  • Yang-Che Wu
  • Julia Yu-Fong Chang
  • Yi-Ping Wang
  • Andy Sun
  • J. Formos. Med. Assoc..2020 Apr;119(4):813-820. S0929-6646(19)30882-4. doi: 10.1016/j.jfma.2019.10.013.Epub 2019-11-01.

アルツハイマー病による進行性認知症症候群:55例の解説と他の表現型との比較

Progressive dysexecutive syndrome due to Alzheimer's disease: a description of 55 cases and comparison to other phenotypes.
  • Ryan A Townley
  • Jonathan Graff-Radford
  • William G Mantyh
  • Hugo Botha
  • Angelina J Polsinelli
  • Scott A Przybelski
  • Mary M Machulda
  • Ahmed T Makhlouf
  • Matthew L Senjem
  • Melissa E Murray
  • Ross R Reichard
  • Rodolfo Savica
  • Bradley F Boeve
  • Daniel A Drubach
  • Keith A Josephs
  • David S Knopman
  • Val J Lowe
  • Clifford R Jack
  • Ronald C Petersen
  • David T Jones
  • Brain Commun.2020;2(1):fcaa068. fcaa068. doi: 10.1093/braincomms/fcaa068.Epub 2020-05-27.

軸性腰痛を有する被験者における腰部硬膜外ステロイド注射に対する反応とタンパク質および遺伝子バイオマーカーとの関連

Association of Protein and Genetic Biomarkers with Response to Lumbar Epidural Steroid Injections in Subjects with Axial Low Back Pain.
  • Stephen Schaaf
  • Wan Huang
  • Subashan Perera
  • Yvette Conley
  • Inna Belfer
  • Prakash Jayabalan
  • Katie Tremont
  • Paulo Coelho
  • Sara Ernst
  • Megan Cortazzo
  • Debra Weiner
  • Nam Vo
  • James Kang
  • Gwendolyn Sowa
  • Am J Phys Med Rehabil.2020 Jun;doi: 10.1097/PHM.0000000000001514.Epub 2020-06-22.

乳がん治療薬として最適化されたポリエチレングリコール化ポリマー-脂質ハイブリッドナノ粒子

Optimized Polyethylene Glycolylated Polymer-Lipid Hybrid Nanoparticles as a Potential Breast Cancer Treatment.
  • Salam Massadeh
  • Mustafa E Omer
  • Asmaa Alterawi
  • Rizwan Ali
  • Fayez H Alanazi
  • Fares Almutairi
  • Wejdan Almotairi
  • Faris F Alobaidi
  • Khulud Alhelal
  • Mansour S Almutairi
  • Abdulaziz Almalik
  • Aiman A Obaidat
  • Manal Alaamery
  • Alaa Eldeen Yassin
  • Pharmaceutics.2020 Jul;12(7). E666. doi: 10.3390/pharmaceutics12070666.Epub 2020-07-15.

再建血管性高血圧症2K1Cのラットで自発的な運動を行った場合、筋細胞内シグナル伝達の調整によりフィットネスが改善される

Fitness is improved by adjustments in muscle intracellular signaling in rats with renovascular hypertension 2K1C undergoing voluntary physical exercise.
  • Taynara Carolina Lima
  • Maria Andrea Barbosa
  • Daniela Caldeira Costa
  • Lenice Kappes Becker
  • Leonardo Máximo Cardoso
  • Andréia Carvalho Alzamora
  • Life Sci..2020 Jun;250:117549. S0024-3205(20)30297-6. doi: 10.1016/j.lfs.2020.117549.Epub 2020-03-13.

耐熱性または高温に敏感なダイズ遺伝子型の子葉系乳腺細胞における種子タンパク質組成とタンパク質貯蔵液胞 の構造に及ぼす熱ストレスの影響

Effect of Heat Stress on Seed Protein Composition and Ultrastructure of Protein Storage Vacuoles in the Cotyledonary Parenchyma Cells of Soybean Genotypes That Are Either Tolerant or Sensitive to Elevated Temperatures.
  • Hari B Krishnan
  • Won-Seok Kim
  • Nathan W Oehrle
  • James R Smith
  • Jason D Gillman
  • Int J Mol Sci.2020 Jul;21(13). E4775. doi: 10.3390/ijms21134775.Epub 2020-07-05.

モザンビークの薬剤耐性ホットスポットにおけるトリパノソーマ症の伝播におけるタバン科とグロッシン科の相対的役割の評価

Evaluation of the relative roles of the Tabanidae and Glossinidae in the transmission of trypanosomosis in drug resistance hotspots in Mozambique.
  • Fernando C Mulandane
  • Louwtjie P Snyman
  • Denise R A Brito
  • Jeremy Bouyer
  • José Fafetine
  • Jan Van Den Abbeele
  • Marinda Oosthuizen
  • Vincent Delespaux
  • Luis Neves
  • Parasit Vectors.2020 Apr;13(1):219. 10.1186/s13071-020-04087-1. doi: 10.1186/s13071-020-04087-1.Epub 2020-04-29.

精神保健および救急サービスにおける看護師との相互作用に関する自殺願望と行動を持つ成人の視点。システマティックレビュー

The perspectives of adults with suicidal ideation and behaviour regarding their interactions with nurses in mental health and emergency services: A systematic review.
  • Joeri Vandewalle
  • Liesbet Van Bos
  • Peter Goossens
  • Dimitri Beeckman
  • Ann Van Hecke
  • Eddy Deproost
  • Sofie Verhaeghe
  • Int J Nurs Stud.2020 Jun;110:103692. S0020-7489(20)30176-0. doi: 10.1016/j.ijnurstu.2020.103692.Epub 2020-06-20.

SARS-CoV-2のNsp1タンパク質によるトランスレーショナルシャットダウンと免疫回避の構造的基盤

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
  • Matthias Thoms
  • Robert Buschauer
  • Michael Ameismeier
  • Lennart Koepke
  • Timo Denk
  • Maximilian Hirschenberger
  • Hanna Kratzat
  • Manuel Hayn
  • Timur Mackens-Kiani
  • Jingdong Cheng
  • Jan H Straub
  • Christina M Stürzel
  • Thomas Fröhlich
  • Otto Berninghausen
  • Thomas Becker
  • Frank Kirchhoff
  • Konstantin M J Sparrer
  • Roland Beckmann
  • Science.2020 Jul;eabc8665. doi: 10.1126/science.abc8665.Epub 2020-07-17.

ジヒドロピリジンカルシウムチャネルブロッカーの皮質および小脳の有機リン酸塩による酸化的損傷に対する治療効果:インビボ試験

Therapeutic Potential of Dihydropyridine Calcium Channel Blockers on Oxidative Injury Caused by Organophosphates in Cortex and Cerebellum: An In Vivo Study.
  • Sara Ataei
  • Susan Abaspanah
  • Rasool Haddadi
  • Mojdeh Mohammadi
  • Amir Nili-Ahmadabadi
  • Indian J Clin Biochem.2020 Jul;35(3):339-346. 830. doi: 10.1007/s12291-019-00830-3.Epub 2019-05-14.