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日本語AIでPubMedを検索

歯科医師情報サイトTop / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
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みんなが読んでいる論文

脳内浸透型のPQR620 mTORとPQR530 PI3K/mTOR阻害剤はHDの細胞モデルにおけるハンチントン病レベルを低下させる

Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD.
  • Elisabeth Singer
  • Carolin Walter
  • Doriano Fabbro
  • Denise Rageot
  • Florent Beaufils
  • Matthias P Wymann
  • Nadine Rischert
  • Olaf Riess
  • Petra Hillmann
  • Huu Phuc Nguyen
  • Neuropharmacology.2020 01;162:107812. S0028-3908(19)30379-X. doi: 10.1016/j.neuropharm.2019.107812.Epub 2019-10-14.

ブラジルにおける非妊娠女性を対象とした活動性梅毒に対するセフィキシムの臨床効果を評価する第 II 相試験（CeBra）

Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra).
  • Melanie M Taylor
  • Edna Oliveira Kara
  • Maria Alix Leite Araujo
  • Mariangela Freitas Silveira
  • Angelica Espinosa Miranda
  • Ivo Castelo Branco Coelho
  • Maria Luiza Bazzo
  • Gerson Fernando Mendes Pereira
  • Silvana Pereira Giozza
  • Ximena Pamela Díaz Bermudez
  • Maeve B Mello
  • Ndema Habib
  • My Huong Nguyen
  • Soe Soe Thwin
  • Nathalie Broutet
  • BMC Infect. Dis..2020 Jun;20(1):405. 10.1186/s12879-020-04980-1. doi: 10.1186/s12879-020-04980-1.Epub 2020-06-10.

T2および拡散強調MRIを用いた子宮頸癌における体積の描出。オブザーバー間の体積の一致

Volume Delineation in Cervical Cancer With T2 and Diffusion-weighted MRI: Agreement on Volumes Between Observers.
  • Consuelo Rosa
  • Andrea Delli Pizzi
  • Antonietta Augurio
  • Luciana Caravatta
  • Monica DI Tommaso
  • Erica Mincuzzi
  • Sebastiano Cinalli
  • Raffaella Basilico
  • Annamaria Porreca
  • Marta DI Nicola
  • Domenico Genovesi
  • In Vivo.2020 Jul-Aug;34(4):1981-1986. 34/4/1981. doi: 10.21873/invivo.11995.

再建手術を受けている乳がん患者に対するマッサージとマッサージプラス鍼治療との比較

Massage Compared with Massage Plus Acupuncture for Breast Cancer Patients Undergoing Reconstructive Surgery.
  • Christina A Dilaveri
  • Ivana T Croghan
  • Molly J Mallory
  • Liza J Dion
  • Karen M Fischer
  • Darrell R Schroeder
  • Jorys Martinez-Jorge
  • Minh-Doan T Nguyen
  • Shawn C Fokken
  • Brent A Bauer
  • Dietlind L Wahner-Roedler
  • J Altern Complement Med.2020 Jul;26(7):602-609. doi: 10.1089/acm.2019.0479.

アルツハイマー病における神経炎症メカニズムの精密医療への道

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease.
  • Harald Hampel
  • Filippo Caraci
  • A Claudio Cuello
  • Giuseppe Caruso
  • Robert Nisticò
  • Massimo Corbo
  • Filippo Baldacci
  • Nicola Toschi
  • Francesco Garaci
  • Patrizia A Chiesa
  • Steven R Verdooner
  • Leyla Akman-Anderson
  • Félix Hernández
  • Jesús Ávila
  • Enzo Emanuele
  • Pedro L Valenzuela
  • Alejandro Lucía
  • Mark Watling
  • Bruno P Imbimbo
  • Andrea Vergallo
  • Simone Lista
  • Front Immunol.2020;11:456. doi: 10.3389/fimmu.2020.00456.Epub 2020-03-31.

帯状疱疹と認知症との関連性と抗ウイルス療法の認知症リスクへの効果：集団ベースのコホート研究

Association of herpes zoster with dementia and effect of antiviral therapy on dementia: a population-based cohort study.
  • Seongman Bae
  • Sung-Cheol Yun
  • Min-Chul Kim
  • Woon Yoon
  • Joon Seo Lim
  • Sang-Oh Lee
  • Sang-Ho Choi
  • Yang Soo Kim
  • Jun Hee Woo
  • Seong Yoon Kim
  • Sung-Han Kim
  • Eur Arch Psychiatry Clin Neurosci.2020 Jul;10.1007/s00406-020-01157-4. doi: 10.1007/s00406-020-01157-4.Epub 2020-07-01.

再治療の長期フォローアップとアウトカム転移性去勢抵抗性前立腺癌におけるルテチウム-177（Lu）PSMA-617療法の拡張50患者単施設第II相前向き試験における再治療の長期フォローアップとアウトカム

Re: Long Term Follow-Up and Outcomes of Re-Treatment in an Expanded 50 Patient Single-Center Phase II Prospective Trial of Lutetium-177 (Lu) PSMA-617 Theranostics in Metastatic Castrate-Resistant Prostate Cancer.
  • Samir S Taneja
  • J. Urol..2020 05;203(5):882. doi: 10.1097/JU.0000000000000779.01.Epub 2020-02-13.

ホルモン受容体陽性/HER2陰性の早期乳癌患者における、免疫組織化学的に定義された腔状サブタイプに応じた用量密度の高い補助化学療法の効果：GIM2試験の探索的解析

Effect of dose-dense adjuvant chemotherapy in hormone receptor positive/HER2-negative early breast cancer patients according to immunohistochemically defined luminal subtype: an exploratory analysis of the GIM2 trial.
  • Benedetta Conte
  • Marco Bruzzone
  • Matteo Lambertini
  • Francesca Poggio
  • Claudia Bighin
  • Eva Blondeaux
  • Michelino De Laurentiis
  • Enrichetta Valle
  • Francesco Cognetti
  • Cecilia Nisticò
  • Sabino De Placido
  • Ornella Garrone
  • Teresa Gamucci
  • Filippo Montemurro
  • Fabio Puglisi
  • Barbara Cardinali
  • Piero Fregatti
  • Loredana Miglietta
  • Francesco Boccardo
  • Marcello Ceppi
  • Lucia Del Mastro
  • Eur. J. Cancer.2020 Jul;136:43-51. S0959-8049(20)30273-2. doi: 10.1016/j.ejca.2020.05.007.Epub 2020-07-04.

高齢マウスにアジュバント組換えインフルエンザ核タンパク質をワクチン接種すると，防御免疫が増強される．

Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity.
  • Tres Cookenham
  • Kathleen G Lanzer
  • Emily Gage
  • Erica C Lorenzo
  • Darrick Carter
  • Rhea N Coler
  • Susan L Baldwin
  • Laura Haynes
  • William W Reiley
  • Marcia A Blackman
  • Vaccine.2020 Jul;38(33):5256-5267. S0264-410X(20)30752-0. doi: 10.1016/j.vaccine.2020.05.085.Epub 2020-06-12.

小児小脳悪性腫瘍の治療を目的とした抗がん剤HSV G207のヒト初の第1相免疫療法臨床試験のデザインと根拠

Design and Rationale for First-In-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors.
  • Joshua D Bernstock
  • Asim Bag
  • John Fiveash
  • Kara Kachurak
  • Galal Elsayed
  • Gustavo Chagoya
  • Florian Gessler
  • Pablo A Valdes
  • Avi Madan-Swain
  • Richard Whitley
  • James Markert
  • Yancey Gillespie
  • James M Johnston
  • Gregory K Friedman
  • Hum. Gene Ther..2020 Jul;doi: 10.1089/hum.2020.101.Epub 2020-07-12.

マンソン病の免疫調節分子Sm16/SPO-1/SmSLPは、トレマトード特異的な蠕虫防御分子（HDM）の一種です

Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs).
  • Jenna Shiels
  • Krystyna Cwiklinski
  • Raquel Alvarado
  • Karine Thivierge
  • Sophie Cotton
  • Bibiana Gonzales Santana
  • Joyce To
  • Sheila Donnelly
  • Clifford C Taggart
  • Sinead Weldon
  • John P Dalton
  • PLoS Negl Trop Dis.2020 Jul;14(7):e0008470. PNTD-D-20-00627. doi: 10.1371/journal.pntd.0008470.Epub 2020-07-09.

DL-3-n-ブチルフタル酸は，大脳動脈硬化性狭窄症患者における脳血流低下を改善する：単施設，無作為化，二重盲検，プラセボ対照試験

DL-3-n-butylphthalide improves cerebral hypoperfusion in patients with large cerebral atherosclerotic stenosis: a single-center, randomized, double-blind, placebo-controlled study.
  • Dawei Chen
  • Yanwei Yin
  • Jin Shi
  • Fen Yang
  • Kehua Wang
  • Faguo Zhao
  • Wenping Li
  • Bin Li
  • BMC Neurol.2020 May;20(1):212. 10.1186/s12883-020-01801-5. doi: 10.1186/s12883-020-01801-5.Epub 2020-05-26.

思春期の若者におけるうつ病とモバイルテクノロジーやソーシャルメディアの利用との関係：アンブレラレビュー

Relationship between depression and the use of mobile technologies and social media among adolescents: an umbrella review.
  • Jorge Arias-de la Torre
  • Elisa Puigdomenech
  • Xavier Garcia
  • Jose M Valderas
  • Francisco Jose Eiroa-Orosa
  • Tania Fernandez-Villa
  • Antonio J Molina
  • Vicente Martin
  • Antoni Serrano-Blanco
  • Jordi Alonso
  • Mireia Espallargues
  • J. Med. Internet Res..2020 Jun;doi: 10.2196/16388.Epub 2020-06-03.

雌のアフリカ産コメ癭蝿（Orseolia oryzivora Harris and Gagné）の電気生理学的・行動学的反応と宿主植物の揮発性物質に対する反応

Electrophysiological and behavioral responses of female African rice gall midge, Orseolia oryzivora Harris and Gagné, to host plant volatiles.
  • Emmanuel O Ogah
  • Lesley E Smart
  • Christine M Woodcock
  • John C Caulfield
  • Michael A Birkett
  • John A Pickett
  • Francis E Nwilene
  • Toby J Bruce
  • J. Chem. Ecol..2017 Jan;43(1):13-16. 10.1007/s10886-016-0788-6. doi: 10.1007/s10886-016-0788-6.Epub 2016-11-04.

声帯瘢痕および声帯溝に対する組換え肝細胞増殖因子を用いた耳内注射の第I/II相探索的臨床試験

A phase I/II exploratory clinical trial for intracordal injection of recombinant hepatocyte growth factor for vocal fold scar and sulcus.
  • Shigeru Hirano
  • Atsuhiko Kawamoto
  • Ichiro Tateya
  • Masanobu Mizuta
  • Yo Kishimoto
  • Nao Hiwatashi
  • Yoshitaka Kawai
  • Takuya Tsuji
  • Ryo Suzuki
  • Mami Kaneko
  • Yasushi Naito
  • Tatsuo Kagimura
  • Tatsuo Nakamura
  • Shin-Ichi Kanemaru
  • J Tissue Eng Regen Med.2018 04;12(4):1031-1038. doi: 10.1002/term.2603.Epub 2017-12-25.

ボトリosphaeranは、Walker-256 腫瘍担持肥満ラットにおける腫瘍の発生と癌性悪液質症候群を減衰させ、これらのラットの代謝学的および血液学的プロフィールを改善する

Botryosphaeran Attenuates Tumor Development and the Cancer Cachexia Syndrome in Walker-256 Tumor-Bearing Obese Rats and Improves the Metabolic and Hematological Profiles of These Rats.
  • Patrícia K Comiran
  • Mariana C Ribeiro
  • John H G Silva
  • Kamila O Martins
  • Izabella A Santos
  • Ana Emilia F Chiaradia
  • Amadeu Z Silva
  • Robert F H Dekker
  • Aneli M Barbosa-Dekker
  • Pâmela Alegranci
  • Eveline A I F Queiroz
  • Nutr Cancer.2020 Jul;:1-18. doi: 10.1080/01635581.2020.1789681.Epub 2020-07-08.

TRPV4はミトコンドリアの輸送を阻害し、CaMKIIに依存した細胞内Caの上昇を介して軸索変性を引き起こす

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca.
  • Brian M Woolums
  • Brett A McCray
  • Hyun Sung
  • Masashi Tabuchi
  • Jeremy M Sullivan
  • Kendra Takle Ruppell
  • Yunpeng Yang
  • Catherine Mamah
  • William H Aisenberg
  • Pamela C Saavedra-Rivera
  • Bryan S Larin
  • Alexander R Lau
  • Douglas N Robinson
  • Yang Xiang
  • Mark N Wu
  • Charlotte J Sumner
  • Thomas E Lloyd
  • Nat Commun.2020 May;11(1):2679. 10.1038/s41467-020-16411-5. doi: 10.1038/s41467-020-16411-5.Epub 2020-05-29.

CD74アイソフォームが41kDaに存在しないことで、ヒト肺腺癌由来細胞におけるCD74とCD44の異型関連が抑制される

Absence of CD74 Isoform at 41kDa Prevents the Heterotypic Associations between CD74 and CD44 in Human Lung Adenocarcinoma-derived Cells.
  • Waleed Al Abdulmonem
  • Zafar Rasheed
  • Abdullah S M Aljohani
  • Ola M Omran
  • Naila Rasheed
  • Abdullah Alkhamiss
  • Abdulaziz A M Al Salloom
  • Fahad Alhumaydhi
  • Mohamd A Alblihed
  • Hussain Al Ssadh
  • Muhammad Ismail Khan
  • Nelson Fernández
  • Immunol. Invest..2020 Jul;:1-15. doi: 10.1080/08820139.2020.1790594.Epub 2020-07-09.

潰瘍性大腸炎患者の実世界コホートにおけるトファシチニブの安全性

Safety of Tofacitinib in a Real-World Cohort of Patients With Ulcerative Colitis.
  • Parakkal Deepak
  • Quazim A Alayo
  • Aava Khatiwada
  • Bixuan Lin
  • Marc Fenster
  • Christina Dimopoulos
  • Geoffrey Bader
  • Roni Weisshof
  • Michael Jacobs
  • Alexandra Gutierrez
  • Matthew A Ciorba
  • George P Christophi
  • Anish Patel
  • Robert P Hirten
  • Jean-Frederic Colombel
  • David T Rubin
  • Christina Ha
  • Poonam Beniwal-Patel
  • Ryan C Ungaro
  • Gaurav Syal
  • Joel Pekow
  • Benjamin L Cohen
  • Andres Yarur
  • Clin. Gastroenterol. Hepatol..2020 Jul;S1542-3565(20)30913-7. doi: 10.1016/j.cgh.2020.06.050.Epub 2020-07-03.

金属汚染環境下で増殖した海洋神経毒性渦鞭毛藻Alexandrium pacificumの膜プロテオーム、細胞増殖、形態測定における異種間の変動性

Intraspecific variability in membrane proteome, cell growth, and morphometry of the invasive marine neurotoxic dinoflagellate Alexandrium pacificum grown in metal-contaminated conditions.
  • Cherif Chetouhi
  • Estelle Masseret
  • Cecilia Teodora Satta
  • Thierry Balliau
  • Mohamed Laabir
  • Natacha Jean
  • Sci. Total Environ..2020 May;715:136834. S0048-9697(20)30344-2. doi: 10.1016/j.scitotenv.2020.136834.Epub 2020-01-25.

大豆タンパク質単離物フィブリルと赤ビートルーツ由来のベタレインとの相互作用。大豆タンパク質単離物フィブリルとベタレインの相互作用：形態学、分光学的特性および熱安定性

Interaction of soy protein isolate fibrils with betalain from red beetroots: Morphology, spectroscopic characteristics and thermal stability.
  • Hui-Shuang Zhao
  • Zhen Ma
  • Pu Jing
  • Food Res. Int..2020 Sep;135:109289. S0963-9969(20)30314-8. doi: 10.1016/j.foodres.2020.109289.Epub 2020-05-05.

COVID-19で入院した最初の63人の成人患者の臨床的特徴と転帰。オマーンでの経験

Clinical characteristics and outcomes of the first 63 adult patients hospitalized with COVID-19: An experience from Oman.
  • Faryal Khamis
  • Ibrahim Al-Zakwani
  • Hamed Al Naamani
  • Sultan Al Lawati
  • Nenad Pandak
  • Muna Ba Omar
  • Maher Al Bahrani
  • Zakaryia Al Bulushi
  • Huda Al Khalili
  • Issa Al Salmi
  • Ruwaida Al Ismaili
  • Salah T Al Awaidy
  • J Infect Public Health.2020 Jul;13(7):906-913. S1876-0341(20)30496-2. doi: 10.1016/j.jiph.2020.06.002.Epub 2020-06-08.

原発性腋窩多汗症患者を対象としたUmeclidiniumの外用薬の薬物動態、安全性、忍容性および臨床効果を評価するための第2a相無作為化比較試験

A phase 2a randomized controlled study to evaluate the pharmacokinetic, safety, tolerability and clinical effect of topically applied Umeclidinium in subjects with primary axillary hyperhidrosis.
  • A Nasir
  • R Bissonnette
  • C Maari
  • J DuBois
  • T Pene Dumitrescu
  • J Haddad
  • Y Yamaguchi
  • M Dalessandro
  • J Eur Acad Dermatol Venereol.2018 Jan;32(1):145-151. doi: 10.1111/jdv.14651.Epub 2017-11-07.

CANVASプログラムにおけるカナグリフロジンとグルカゴン様ペプチド-1受容体アゴニストの併用療法の心血管リスクの中間マーカーに対する効果

The effects of combination canagliflozin and glucagon-like peptide-1 receptor agonist therapy on intermediate markers of cardiovascular risk in the CANVAS program.
  • Clare Arnott
  • Brendon L Neuen
  • Hiddo J L Heerspink
  • Gemma A Figtree
  • Mikhail Kosiborod
  • Carolyn S Lam
  • Christopher P Cannon
  • Norman Rosenthal
  • Wayne Shaw
  • Kenneth W Mahaffey
  • Meg J Jardine
  • Vlado Perkovic
  • Bruce Neal
  • Int. J. Cardiol..2020 Jun;S0167-5273(20)33389-1. doi: 10.1016/j.ijcard.2020.06.011.Epub 2020-06-20.

養子縁組前の逆境にある子どもの注意欠陥のリスクを調節する。家庭外プレースメントと子どもの強化されたエラーモニタリングのより短い期間の保護的役割

Moderating the Risk for Attention Deficits in Children with Pre-Adoptive Adversity: The Protective Role of Shorter Duration of out of Home Placement and Children's Enhanced Error Monitoring.
  • Tahl I Frenkel
  • Bonny Donzella
  • Kristin A Frenn
  • Sofie Rousseau
  • Nathan A Fox
  • Megan R Gunnar
  • J Abnorm Child Psychol.2020 Jun;10.1007/s10802-020-00671-2. doi: 10.1007/s10802-020-00671-2.Epub 2020-06-30.

Cycloarta-23-ene-3beta,25-diolはEuphorbia spinidens由来の五環ステロイドであり、分子ドッキングによるCOX阻害剤として、スイスの雄性マウスとWistarラットにおける鎮痛・抗炎症活性のin vivoでの研究を行った

Cycloarta-23-ene-3beta,25-diol a pentacyclic steroid from Euphorbia spinidens, as COX inhibitor with molecular docking, and in vivo study of its analgesic and anti-inflammatory activities in male Swiss mice and Wistar rats.
  • Valiollah Hajhashemi
  • Mustafa Ghanadian
  • Abbasali Palizaban
  • Karim Mahnam
  • Hamed Eshaghi
  • Bahareh Gheisari
  • Hojjat Sadeghi-Aliabadi
  • Prostaglandins Other Lipid Mediat..2020 Jul;:106473. S1098-8823(20)30066-6. doi: 10.1016/j.prostaglandins.2020.106473.Epub 2020-07-04.

公的ADL尺度を用いた入院患者の転倒予測モデルの開発：急性期医療における7,858人の患者を対象としたレトロスペクティブ観察研究

New predictive models for falls among inpatients using public ADL scale in Japan: A retrospective observational study of 7,858 patients in acute care setting.
  • Masaki Tago
  • Naoko E Katsuki
  • Yoshimasa Oda
  • Eiji Nakatani
  • Takashi Sugioka
  • Shu-Ichi Yamashita
  • PLoS ONE.2020;15(7):e0236130. PONE-D-20-14794. doi: 10.1371/journal.pone.0236130.Epub 2020-07-16.

バナナMaSPL16はリコピンβ-サイクラーゼ遺伝子の転写を活性化することで、果実の成熟期におけるカロテノイド生合成を調節する

Banana MaSPL16 Modulates Carotenoid Biosynthesis during Fruit Ripening through Activating the Transcription of Lycopene β-Cyclase Genes.
  • Li-Sha Zhu
  • Shu-Min Liang
  • Lu-Lu Chen
  • Chao-Jie Wu
  • Wei Wei
  • Wei Shan
  • Jian-Ye Chen
  • Wang-Jin Lu
  • Xin-Guo Su
  • Jian-Fei Kuang
  • J. Agric. Food Chem..2020 Feb;68(5):1286-1296. doi: 10.1021/acs.jafc.9b07134.Epub 2020-01-24.