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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

未治療の多発性骨髄腫におけるメルファラン、プレドニゾロン、ボルテゾミブの最適化を目的とした無作為化第II相試験(JCOG1105

Randomised phase II study to optimise melphalan, prednisolone, and bortezomib in untreated multiple myeloma (JCOG1105).
  • Dai Maruyama
  • Shinsuke Iida
  • Gakuto Ogawa
  • Noriko Fukuhara
  • Sachiko Seo
  • Kana Miyazaki
  • Makoto Yoshimitsu
  • Junya Kuroda
  • Norifumi Tsukamoto
  • Hideki Tsujimura
  • Akira Hangaishi
  • Takahiro Yamauchi
  • Takahiko Utsumi
  • Ishikazu Mizuno
  • Yasushi Takamatsu
  • Yasuyuki Nagata
  • Koichiro Minauchi
  • Eiichi Ohtsuka
  • Ichiro Hanamura
  • Shinichiro Yoshida
  • Satoshi Yamasaki
  • Youko Suehiro
  • Yutaro Kamiyama
  • Kunihiro Tsukasaki
  • Hirokazu Nagai
  • Br. J. Haematol..2020 Jun;doi: 10.1111/bjh.16878.Epub 2020-06-24.

Plantamajoside は、Akt/NF-κB 経路の不活性化を介して、ラット糸球体中膜細胞における高グルコース誘発性酸化ストレス、炎症、細胞外マトリックス蓄積を抑制します

Plantamajoside inhibits high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in rat glomerular mesangial cells through the inactivation of Akt/NF-κB pathway.
  • Dongmei Xiao
  • Rui Yang
  • Li Gong
  • Yawei Zhang
  • Yongli Xie
  • Shenjue Ni
  • J. Recept. Signal Transduct. Res..2020 Jul;:1-8. doi: 10.1080/10799893.2020.1784939.Epub 2020-07-01.

小児におけるNF1様視路グリオーマ:この特異的な症例の臨床的および分子的特徴付け

NF1-like optic pathway gliomas in children: clinical and molecular characterization of this specific presentation.
  • María Jesús Lobón-Iglesias
  • Ingrid Laurendeau
  • Léa Guerrini-Rousseau
  • Arnault Tauziède-Espariat
  • Audrey Briand-Suleau
  • Pascale Varlet
  • Dominique Vidaud
  • Michel Vidaud
  • Laurence Brugieres
  • Jacques Grill
  • Eric Pasmant
  • Neurooncol Adv.2020 Jul;2(Suppl 1):i98-i106. vdz054. doi: 10.1093/noajnl/vdz054.Epub 2019-12-20.

移植前にWT1発現が低かった急性骨髄性白血病患者を対象とした末梢血幹細胞移植のミロアブレーション(CyTBI、BuCy)対低強度化(FluBu2TBI400)の比較

Comparison of myeloablative (CyTBI, BuCy) versus reduced-intensity (FluBu2TBI400) peripheral blood stem cell transplantation in acute myeloid leukemia patients with pre-transplant low WT1 expression.
  • Silvia Park
  • Gi June Min
  • Sung Soo Park
  • Seung-Ah Yahng
  • Young-Woo Jeon
  • Seung-Hwan Shin
  • Jae-Ho Yoon
  • Sung-Eun Lee
  • Byung Sik Cho
  • Ki-Seong Eom
  • Yoo-Jin Kim
  • Seok Lee
  • Chang-Ki Min
  • Seok-Goo Cho
  • Dong-Wook Kim
  • Jong Wook Lee
  • Hee-Je Kim
  • Biol. Blood Marrow Transplant..2020 Jul;S1083-8791(20)30415-8. doi: 10.1016/j.bbmt.2020.07.006.Epub 2020-07-10.

乳がん化学療法の選択肢。ヌクレオ脂質ナノシステム内に配置されたマルチターゲットルテニウム(III)錯体の前臨床検証に関する一般的な概要

Breast Cancer Chemotherapeutic Options: A General Overview on the Preclinical Validation of a Multi-Target Ruthenium(III) Complex Lodged in Nucleolipid Nanosystems.
  • Maria Grazia Ferraro
  • Marialuisa Piccolo
  • Gabriella Misso
  • Francesco Maione
  • Daniela Montesarchio
  • Michele Caraglia
  • Luigi Paduano
  • Rita Santamaria
  • Carlo Irace
  • Cells.2020 Jun;9(6). E1412. doi: 10.3390/cells9061412.Epub 2020-06-05.

韓国人患者における軽鎖近位尿細管症の臨床病理学的特徴と免疫グロブリン軽鎖の免疫組織化学染色の診断有用性

Clinicopathological characteristics of light chain proximal tubulopathy in Korean patients and the diagnostic usefulness of immunohistochemical staining for immunoglobulin light chain.
  • Minsun Jung
  • Youngeun Lee
  • Hajeong Lee
  • Kyung Chul Moon
  • BMC Nephrol.2020 Apr;21(1):146. 10.1186/s12882-020-01813-w. doi: 10.1186/s12882-020-01813-w.Epub 2020-04-23.

早期のM-タンパク質動態は再発・難治性多発性骨髄腫患者の無増悪生存率を予測する

Early M-Protein Dynamics Predicts Progression-Free Survival in Patients With Relapsed/Refractory Multiple Myeloma.
  • Xiaoyu Yan
  • Xu Steven Xu
  • Katja C Weisel
  • Maria-Victoria Mateos
  • Pieter Sonneveld
  • Meletios A Dimopoulos
  • Saad Zafar Usmani
  • Nizar J Bahlis
  • Thomas Puchalski
  • Jon Ukropec
  • Kevin Bellew
  • Qi Ming
  • Steven Sun
  • Honghui Zhou
  • Clin Transl Sci.2020 Jun;doi: 10.1111/cts.12836.Epub 2020-06-25.

AAVα-シヌクレインを用いたパーキンソン病モデルラットにおけるα-シヌクレイン誘発性変化の電気生理学的測定による分類

Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson's disease using electrophysiological measurements of visual processing.
  • Freja Gam Østergaard
  • Marc M Himmelberg
  • Bettina Laursen
  • Hartwig R Siebner
  • Alex R Wade
  • Kenneth Vielsted Christensen
  • Sci Rep.2020 Jul;10(1):11869. 10.1038/s41598-020-68808-3. doi: 10.1038/s41598-020-68808-3.Epub 2020-07-17.

隣接する多発性歯肉後退の治療における修正冠状先進フラップ単独または血小板リッチフィブリン膜との併用の臨床評価:6ヶ月間の研究

Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study.
  • Sofia Aroca
  • Tibor Keglevich
  • Bruno Barbieri
  • Istvan Gera
  • Daniel Etienne
  • J. Periodontol..2009 Feb;80(2):244-52. 10.1902/jop.2009.080253. doi: 10.1902/jop.2009.080253 .

エチオピア北西部デンビアの農村部に住む5歳未満の子どもたちにおける一般的な消化器症状と関連因子。エチオピア北西部デンビアの農村部における5歳未満児の一般的な消化器症状と関連因子:コミュニティベースの横断的調査

Common Gastrointestinal Symptoms and Associated Factors Among Under-5 Children in Rural Dembiya, Northwest Ethiopia: A Community-Based Cross-Sectional Study.
  • Zemichael Gizaw
  • Ayenew Addisu
  • Destaye Guadie
  • Environ Health Insights.2020;14:1178630220927361. 10.1177_1178630220927361. doi: 10.1177/1178630220927361.Epub 2020-06-17.

細胞外容積の状態は、糖尿病性腎疾患におけるSGLT2阻害薬ダパグリフロジンに対する体液反応を予測する

The extracellular volume status predicts body fluid response to SGLT2 inhibitor dapagliflozin in diabetic kidney disease.
  • Ken Ohara
  • Takahiro Masuda
  • Masato Morinari
  • Mari Okada
  • Atsushi Miki
  • Saki Nakagawa
  • Takuya Murakami
  • Kentaro Oka
  • Maki Asakura
  • Yasuharu Miyazawa
  • Akito Maeshima
  • Tetsu Akimoto
  • Osamu Saito
  • Daisuke Nagata
  • Diabetol Metab Syndr.2020;12:37. 545. doi: 10.1186/s13098-020-00545-z.Epub 2020-05-01.

急性骨髄性白血病患者を対象に,グラゼギブと低用量シタラビンで治療した場合の治療反応に応じた生存期間の転帰と臨床的有用性

Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy.
  • Jorge E Cortes
  • Florian H Heidel
  • Walter Fiedler
  • B Douglas Smith
  • Tadeusz Robak
  • Pau Montesinos
  • Anna Candoni
  • Brian Leber
  • Mikkael A Sekeres
  • Daniel A Pollyea
  • Roxanne Ferdinand
  • Weidong Wendy Ma
  • Thomas O'Brien
  • Ashleigh O'Connell
  • Geoffrey Chan
  • Michael Heuser
  • J Hematol Oncol.2020 Jul;13(1):92. 10.1186/s13045-020-00929-8. doi: 10.1186/s13045-020-00929-8.Epub 2020-07-14.

オピオイド過剰摂取死亡率と関連した州のナロキソン入手法の地域的変動-観察研究(STROBE準拠)

Regional variation in states' naloxone accessibility laws in association with opioid overdose death rates-Observational study (STROBE compliant).
  • Hyo-Sun You
  • Jane Ha
  • Cyra-Y Kang
  • Leeseul Kim
  • Jinah Kim
  • Jay J Shen
  • Seong-Min Park
  • Sung-Youn Chun
  • Jinwook Hwang
  • Takashi Yamashita
  • Se Won Lee
  • Georgia Dounis
  • Yong-Jae Lee
  • Dong-Hun Han
  • David Byun
  • Ji Won Yoo
  • Hee-Taik Kang
  • Medicine (Baltimore).2020 May;99(22):e20033. 00005792-202005290-00018. doi: 10.1097/MD.0000000000020033.

CCND1およびMYC転座を有する"ダブルヒット"マントル細胞リンパ腫がリツキシマブ・ベンダムスチン・シタラビン(R-BAC)およびイブルチニブに再発/難治した1例

A case of "double hit" mantle cell lymphoma carrying CCND1 and MYC translocations relapsed/refractory to rituximab bendamustine cytarabine (R-BAC) and ibrutinib.
  • Greta Scapinello
  • Marcello Riva
  • Antonio Branca
  • Marco Pizzi
  • Laura Bonaldi
  • Annalisa Martines
  • Sabrina Manni
  • Andrea Visentin
  • Livio Trentin
  • Gianpietro Semenzato
  • Carmela Gurrieri
  • Francesco Piazza
  • Ann. Hematol..2020 Jul;10.1007/s00277-020-04178-0. doi: 10.1007/s00277-020-04178-0.Epub 2020-07-15.

フォローアップ研究。抗生物質を含浸させたポリメチルメタクリレートプレートと組織エキスパンダーの同時交換を用いた感染した人工乳房再建のワンステップサルベージ

Follow-Up Study: One-Step Salvage of Infected Prosthetic Breast Reconstructions Using Antibiotic-Impregnated Polymethylmethacrylate Plates and Concurrent Tissue Expander Exchange.
  • Amy S Xue
  • Angela S Volk
  • Valerie L DeGregorio
  • Kevin T Jubbal
  • Jamal M Bullocks
  • Shayan A Izaddoost
  • Plast. Reconstr. Surg..2020 Feb;145(2):240e-250e. 00006534-202002000-00005. doi: 10.1097/PRS.0000000000006501.

子どもの食事にバイオ強化されたオレンジ色の肉付きサツマイモを取り入れようとする意思の予測因子.ケニアの農村部におけるフィールド情報実験

Predictors of Intention to Integrate Biofortified Orange-fleshed Sweetpotato in Child Feeding: A Field Information Experiment in Rural Kenya.
  • Carl Johan Lagerkvist
  • Janet Mwende Mutiso
  • Julius Juma Okello
  • Penina Muoki
  • Willis Oluoch-Kosura
  • Simon Heck
  • Ecol Food Nutr.2020 May;:1-24. doi: 10.1080/03670244.2020.1759576.Epub 2020-05-14.

ポーランド産のヘマトファガウススピントゥルニクスミョウティダニ(Acari: Mesostigmata)とその宿主であるコウモリ(Yangochiroptera: Vespertilionidae)のBartonellaとRickettsia感染症について調べた

Bartonella and Rickettsia Infections in Haematophagous Spinturnix myoti Mites (Acari: Mesostigmata) and their Bat Host, Myotis myotis (Yangochiroptera: Vespertilionidae), from Poland.
  • Agnieszka Szubert-Kruszyńska
  • Joanna Stańczak
  • Stella Cieniuch
  • Edyta Podsiadły
  • Tomasz Postawa
  • Jerzy Michalik
  • Microb. Ecol..2019 Apr;77(3):759-768. 10.1007/s00248-018-1246-5. doi: 10.1007/s00248-018-1246-5.Epub 2018-08-27.

高血圧ラットにおける内皮および心機能の変化とバイオマーカーレベルにおけるTRPV1受容体および一酸化窒素の活性化の役割

The Role of the Activation of the TRPV1 Receptor and of Nitric Oxide in Changes in Endothelial and Cardiac Function and Biomarker Levels in Hypertensive Rats.
  • Juan Carlos Torres-Narváez
  • Israel Pérez-Torres
  • Vicente Castrejón-Téllez
  • Elvira Varela-López
  • Víctor Hugo Oidor-Chan
  • Verónica Guarner-Lans
  • Álvaro Vargas-González
  • Raúl Martínez-Memije
  • Pedro Flores-Chávez
  • Etzna Zizith Cervantes-Yañez
  • Claudia Angélica Soto-Peredo
  • Gustavo Pastelín-Hernández
  • Leonardo Del Valle-Mondragón
  • Int J Environ Res Public Health.2019 09;16(19). E3576. doi: 10.3390/ijerph16193576.Epub 2019-09-25.

虚血と再灌流を受けたラット肝臓における酸化ストレスの強度のシタグリプチン依存性の違い

Sitagliptin-Dependent Differences in the Intensity of Oxidative Stress in Rat Livers Subjected to Ischemia and Reperfusion.
  • Małgorzata Trocha
  • Małgorzata Krzystek-Korpacka
  • Anna Merwid-Ląd
  • Beata Nowak
  • Małgorzata Pieśniewska
  • Piotr Dzięgiel
  • Agnieszka Gomułkiewicz
  • Przemysław Kowalski
  • Dorota Diakowska
  • Adam Szeląg
  • Tomasz Sozański
  • Oxid Med Cell Longev.2019;2019:2738605. doi: 10.1155/2019/2738605.Epub 2019-10-31.

高分解能質量分析法と理論モデルの電子タバコエアロゾル中の多機能カルボニル類と有機酸の定量への応用

Application of High-Resolution Mass Spectrometry and a Theoretical Model to the Quantification of Multifunctional Carbonyls and Organic Acids in e-Cigarette Aerosol.
  • Yichen Li
  • Amanda E Burns
  • Guy J P Burke
  • Morgan E Poindexter
  • Amy K Madl
  • Kent E Pinkerton
  • Tran B Nguyen
  • Environ. Sci. Technol..2020 05;54(9):5640-5650. doi: 10.1021/acs.est.9b07387.Epub 2020-04-23.

プロスタグランジン F は無月経乳牛の排卵前卵胞特性および人工授精あたりの妊娠に影響を与える

Prostaglandin F influences pre-ovulatory follicle characteristics and pregnancy per AI in anovular dairy cows.
  • F R Lopes
  • L M Silva
  • R Zimpel
  • A K Munhoz
  • A Vieira-Neto
  • M H C Pereira
  • M Poindexter
  • M L Gambarini
  • W W Thatcher
  • J L M Vasconcelos
  • J E P Santos
  • Theriogenology.2020 Sep;153:122-132. S0093-691X(20)30273-9. doi: 10.1016/j.theriogenology.2020.04.038.Epub 2020-05-06.

メタドン維持療法を受けている注射薬使用者におけるHIV薬物耐性変異の増加は認められない。プロスペクティブコホート研究

No Increase in HIV Drug Resistance Mutations among Injecting Drug Users on Methadone Maintenance Therapy: A Prospective Cohort Study.
  • Chunyuan Huang
  • Li Ye
  • Abu S Abdullah
  • Bingyu Liang
  • Junjun Jiang
  • Chuanyi Ning
  • Ning Zang
  • Yu Zhang
  • Yuan Yang
  • Xi Hu
  • Quanlue Yang
  • Chaolian Luo
  • Feixiang Lao
  • Huifang Liu
  • Hao Liang
  • Jiegang Huang
  • Curr. HIV Res..2020 Jul;CHR-EPUB-108100. doi: 10.2174/1570162X18666200712173630.Epub 2020-07-12.

ヒトT細胞白血病ウイルス統合における宿主タンパク質のハイジャックの構造的基盤

Structural basis of host protein hijacking in human T-cell leukemia virus integration.
  • Veer Bhatt
  • Ke Shi
  • Daniel J Salamango
  • Nicholas H Moeller
  • Krishan K Pandey
  • Sibes Bera
  • Thomas E Bohl
  • Fredy Kurniawan
  • Kayo Orellana
  • Wei Zhang
  • Duane P Grandgenett
  • Reuben S Harris
  • Anna C Sundborger-Lunna
  • Hideki Aihara
  • Nat Commun.2020 Jun;11(1):3121. 10.1038/s41467-020-16963-6. doi: 10.1038/s41467-020-16963-6.Epub 2020-06-19.

内皮足場タンパク質 ENH (Enigma Homolog Protein)は、PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)を介して、AKT1とeNOS (Endothelial NO Synthase)の脱リン酸化を促進し、血管リモデリングを促進する

Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling.
  • Jiaqi Huang
  • Changhong Cai
  • Tianyu Zheng
  • Xinyan Wu
  • Dongfei Wang
  • Kaijie Zhang
  • Bocheng Xu
  • Ruochen Yan
  • Hui Gong
  • Jie Zhang
  • Yueli Shi
  • Zhiyong Xu
  • Xue Zhang
  • Xuemin Zhang
  • Tao Shang
  • Jianhong Zhou
  • Xiaogang Guo
  • Chunlai Zeng
  • En Yin Lai
  • Changchun Xiao
  • Ju Chen
  • Shu Wan
  • Wen-Hsien Liu
  • Yuehai Ke
  • Hongqiang Cheng
  • Arterioscler. Thromb. Vasc. Biol..2020 Jul;40(7):1705-1721. doi: 10.1161/ATVBAHA.120.314172.Epub 2020-04-09.

選択的レーザー溶解により製造されたチタンの表面改質は、マイトジェン活性化プロテインキナーゼシグナル伝達経路を介して破骨細胞の分化を抑制した

Surface modification of titanium manufactured through selective laser melting inhibited osteoclast differentiation through mitogen-activated protein kinase signaling pathway.
  • Jiamin Yang
  • Xiaolin Yu
  • Zhengchuan Zhang
  • Ruogu Xu
  • Fan Wu
  • Tianlu Wang
  • Yun Liu
  • Jianglin Ouyang
  • Feilong Deng
  • J Biomater Appl.2020 Aug;35(2):169-181. doi: 10.1177/0885328220920457.Epub 2020-04-27.

腫瘍微小環境の組成と重度のサイトカイン放出症候群(CRS)は、アクシカバトゲン シロロイセルで治療された大規模B細胞リンパ腫患者の毒性に影響を与える

Tumor Microenvironment composition and severe cytokine release syndrome (CRS) Influence Toxicity in Patients with Large B Cell Lymphoma Treated with Axicabtagene Ciloleucel.
  • Rawan G Faramand
  • Michael D Jain
  • Verena Staedtke
  • Hiroshi Kotani
  • Ren-Yuan Bai
  • Kayla Reid
  • Sae Bom Lee
  • Kristen Spitler
  • Xuefeng Wang
  • Biwei Cao
  • Javier Pinilla
  • Aleksandr Lazaryan
  • Farhad Khimani
  • Bijal D Shah
  • Julio Chavez
  • Taiga Nishihori
  • Asmita Mishra
  • John E Mullinax
  • Ricardo Gonzalez
  • Mohammad Hussaini
  • Marian Dam
  • Brigett Brandjes
  • Christina A Bachmeier
  • Claudio Anasetti
  • Frederick L Locke
  • Marco L Davila
  • Clin. Cancer Res..2020 Jul;clincanres.1434.2020. doi: 10.1158/1078-0432.CCR-20-1434.Epub 2020-07-15.

私たちは皆、保健サービスを受ける権利を同じように持っている」:モザンビークにおけるナマティの法的エンパワーメント・プログラムの事例研究

'We all have the same right to have health services': a case study of Namati's legal empowerment program in Mozambique.
  • Marta Schaaf
  • Joana Falcao
  • Ellie Feinglass
  • Erin Kitchell
  • Nadja Gomes
  • Lynn Freedman
  • BMC Public Health.2020 Jul;20(1):1084. 10.1186/s12889-020-09190-7. doi: 10.1186/s12889-020-09190-7.Epub 2020-07-10.

大腸癌細胞におけるGOLPH3/AKT1/mTOR軸を介した化学療法誘発ゴルジ装置断片化の保護におけるmiR-3135bの新規な役割

A novel protective role for microRNA-3135b in Golgi apparatus fragmentation induced by chemotherapy via GOLPH3/AKT1/mTOR axis in colorectal cancer cells.
  • Stephanie I Núñez-Olvera
  • Bibiana Chávez-Munguía
  • María Cruz Del Rocío Terrones-Gurrola
  • Laurence A Marchat
  • Jonathan Puente-Rivera
  • Erika Ruíz-García
  • Alma D Campos-Parra
  • Carlos Vázquez-Calzada
  • Erik R Lizárraga-Verdugo
  • Rosalío Ramos-Payán
  • Yarely M Salinas-Vera
  • César López-Camarillo
  • Sci Rep.2020 Jun;10(1):10555. 10.1038/s41598-020-67550-0. doi: 10.1038/s41598-020-67550-0.Epub 2020-06-29.

低酸素誘導性第1因子シグナル伝達経路における遺伝子のメチル化と発現の差は、乳がん生存者におけるパクリタキセル誘発末梢神経障害と化学療法誘発神経障害性疼痛の前臨床モデルと関連していた

Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pain.
  • Kord M Kober
  • Man-Cheung Lee
  • Adam Olshen
  • Yvette P Conley
  • Marina Sirota
  • Michael Keiser
  • Marilyn J Hammer
  • Gary Abrams
  • Mark Schumacher
  • Jon D Levine
  • Christine Miaskowski
  • Mol Pain.2020 Jan-Dec;16:1744806920936502. doi: 10.1177/1744806920936502.

乳がん抑制作用を有するキノコ抽出物と化合物:培養がん細胞、腫瘍担持動物を用いた研究、臨床試験からのエビデンス

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials.
  • Jack Ho Wong
  • Tzi Bun Ng
  • Helen Hei Ling Chan
  • Qin Liu
  • Gene Chi Wai Man
  • Chris Zhiyi Zhang
  • Suzhen Guan
  • Charlene Cheuk Wing Ng
  • Evandro Fei Fang
  • Hexiang Wang
  • Fang Liu
  • Xiuyun Ye
  • Krzysztof Rolka
  • Ryno Naude
  • Shuang Zhao
  • Ou Sha
  • Chunman Li
  • Lixin Xia
  • Appl. Microbiol. Biotechnol..2020 Jun;104(11):4675-4703. 10.1007/s00253-020-10476-4. doi: 10.1007/s00253-020-10476-4.Epub 2020-04-09.

また、メタボリックシンドロームモデルマウスの脂肪組織のトランスクリプトーム解析により、疾患発症に関連する遺伝子シグネチャーを同定した

Transcriptome analysis of the adipose tissue in a mouse model of metabolic syndrome identifies gene signatures related to disease pathogenesis.
  • Dimitris Nasias
  • Katerina Dalakoura-Karagkouni
  • Despoina Vassou
  • Giorgos Papagiannakis
  • Ariadni Papadaki
  • Dimitris Kardassis
  • Genomics.2020 Jul;S0888-7543(19)31032-8. doi: 10.1016/j.ygeno.2020.06.053.Epub 2020-07-08.

COMPASS試験では、血栓透過性は吸引血栓摘出術のファーストパス成功と関連している

Clot perviousness is associated with first pass success of aspiration thrombectomy in the COMPASS trial.
  • Maxim Mokin
  • Muhammad Waqas
  • Johanna Fifi
  • Reade De Leacy
  • David Fiorella
  • Elad I Levy
  • Kenneth Snyder
  • Ricardo Hanel
  • Keith Woodward
  • Imran Chaudry
  • Ansaar T Rai
  • Donald Frei
  • Josser E Delgado Almandoz
  • Michael Kelly
  • Adam S Arthur
  • Blaise W Baxter
  • Joey English
  • Italo Linfante
  • Kyle M Fargen
  • Aquilla Turk
  • Adnan H Siddiqui
  • J Mocco
  • J Neurointerv Surg.2020 Jul;neurintsurg-2020-016434. doi: 10.1136/neurintsurg-2020-016434.Epub 2020-07-17.

血管透過性のダウンレギュレーションと炎症性・酸化性障害の保護を介した敗血症関連急性肺・腎障害に対するマンギフェリンの治療効果

Therapeutic effects of mangiferin on sepsis-associated acute lung and kidney injuries via the downregulation of vascular permeability and protection of inflammatory and oxidative damages.
  • Dong Zhang
  • Shasha Han
  • Yue Zhou
  • Boyang Qi
  • Xiaozhi Wang
  • Eur J Pharm Sci.2020 Jun;152:105400. S0928-0987(20)30189-5. doi: 10.1016/j.ejps.2020.105400.Epub 2020-06-12.

前立腺特異抗原値が上昇した高齢男性患者の病理組織学、薬物療法、前立腺悪性腫瘍の予測因子-プロスペクティブ研究

Histopathology, pharmacotherapy, and predictors of prostatic malignancy in elderly male patients with raised prostate-specific antigen levels - A prospective study.
  • Dhinesh Kumar Mathaiyan
  • Satya Prakash Tripathi
  • Jeffrey Pradeep Raj
  • Bodapati Sivaramakrishna
  • Urol Ann.2020 Apr-Jun;12(2):132-137. UA-12-132. doi: 10.4103/UA.UA_68_19.Epub 2020-04-14.

ハイスループット毒素生産戦略と組み合わせたベノミクスアプローチにより、最初のベノミクス由来メラノコルチン受容体アゴニストが同定された

A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
  • Steve Reynaud
  • Justyna Ciolek
  • Michel Degueldre
  • Natalie J Saez
  • Ana Filipa Sequeira
  • Yoan Duhoo
  • Joana L A Brás
  • Hervé Meudal
  • Miguel Cabo Díez
  • Victoria Fernández Pedrosa
  • Marion Verdenaud
  • Julia Boeri
  • Oscar Pereira Ramos
  • Frédéric Ducancel
  • Margot Vanden Driessche
  • Rudy Fourmy
  • Aude Violette
  • Grégory Upert
  • Gilles Mourier
  • Annette G Beck-Sickinger
  • Karin Mörl
  • Céline Landon
  • Carlos M G A Fontes
  • Rebeca Miñambres Herráiz
  • Ricardo C Rodríguez de la Vega
  • Steve Peigneur
  • Jan Tytgat
  • Loïc Quinton
  • Edwin De Pauw
  • Renaud Vincentelli
  • Denis Servent
  • Nicolas Gilles
  • J. Med. Chem..2020 Jul;doi: 10.1021/acs.jmedchem.0c00485.Epub 2020-07-16.

希少な進行性前立腺がん変異型-腺扁平上皮がん、多形巨細胞がん、および肉腫性がん:19例の解析

Gene Fusion Characterization of Rare Aggressive Prostate Cancer Variants - Adenosquamous Carcinoma, Pleomorphic Giant Cell Carcinoma, and Sarcomatoid Carcinoma: An Analysis of 19 Cases.
  • Mohamed Alhamar
  • Tudor Vladislav
  • Steven C Smith
  • Yuan Gao
  • Liang Cheng
  • Laura A Favazza
  • Ali M Alani
  • Michael M Ittmann
  • Nicole D Riddle
  • Lisa J Whiteley
  • Nilesh S Gupta
  • Shannon Carskadon
  • Juan C Gomez-Gelvez
  • Dhananjay A Chitale
  • Nallasivam Palanisamy
  • Ondrej Hes
  • Kiril Trpkov
  • Sean R Williamson
  • Histopathology.2020 Jul;doi: 10.1111/his.14205.Epub 2020-07-08.

逆相高速液体クロマトグラフィーとパルスアンペロメトリック検出を組み合わせた、白人参中の6つの非極性ジンセノサイドの同時定量

Simultaneous quantification of six nonpolar ginsenosides in white ginseng by reverse-phase high-performance liquid chromatography coupled with integrated pulsed amperometric detection.
  • Hyeyoung Song
  • Kyung-Won Song
  • Seon-Pyo Hong
  • J Ginseng Res.2020 Jul;44(4):563-569. S1226-8453(19)30001-6. doi: 10.1016/j.jgr.2019.07.002.Epub 2019-07-26.

酸性スフィンゴミエリン酵素の直接かつ特異的な阻害剤である低分子ARC39のin vitroでの特性評価

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro.
  • Eyad Naser
  • Stephanie Kadow
  • Fabian Schumacher
  • Zainelabdeen H Mohamed
  • Christian Kappe
  • Gabriele Hessler
  • Barbara Pollmeier
  • Burkhard Kleuser
  • Christoph Arenz
  • Katrin Anne Becker
  • Erich Gulbins
  • Alexander Carpinteiro
  • J. Lipid Res..2020 Jun;61(6):896-910. jlr.RA120000682. doi: 10.1194/jlr.RA120000682.Epub 2020-03-10.

血漿中および気管支肺胞液中の IL-17A および IL-35 のレベルの上昇は、非小細胞肺がん患者におけるチェックポイント阻害剤肺炎と関連している

Elevated levels of IL-17A and IL-35 in plasma and bronchoalveolar lavage fluid are associated with checkpoint inhibitor pneumonitis in patients with non-small cell lung cancer.
  • Yi Na Wang
  • Dan Feng Lou
  • Dan Yang Li
  • Wei Jiang
  • Jing Yin Dong
  • Wei Gao
  • Hong Chao Chen
  • Oncol Lett.2020 Jul;20(1):611-622. OL-0-0-11618. doi: 10.3892/ol.2020.11618.Epub 2020-05-13.

緑膿菌を標的とした工学的低分子ピリンの免疫増強:免疫情報学的調査と積極的な免疫化の組み合わせ

Immunopotentiation of the engineered low-molecular-weight pilin targeting Pseudomonas aeruginosa: A combination of immunoinformatics investigation and active immunization.
  • Yasaman Ahmadbeigi
  • Alireza Salimi Chirani
  • Neda Soleimani
  • Mehdi Mahdavi
  • Mehdi Goudarzi
  • Mol. Immunol..2020 Aug;124:70-82. S0161-5890(20)30350-3. doi: 10.1016/j.molimm.2020.05.009.Epub 2020-06-12.

膵頭十二指腸摘術後の術前赤血球平均コルプスキュラー容積と感染症合併症との間に有意な関連があることを示した

Significant association between the preoperative erythrocyte mean corpuscular volume and infectious complications after pancreaticoduodenectomy.
  • Katsunori Sakamoto
  • Kohei Ogawa
  • Hitoshi Inoue
  • Mikiya Shine
  • Takashi Matsui
  • Yusuke Nishi
  • Takeshi Utsunomiya
  • Kei Tamura
  • Akihiro Takai
  • Yasutsugu Takada
  • Surg. Today.2020 Jul;10.1007/s00595-020-02083-7. doi: 10.1007/s00595-020-02083-7.Epub 2020-07-17.

サハラ以南のアフリカにおける低窒素投入条件でのトウモロコシ収量に対する気候変動の影響をモデル化する

Modelling climate change impacts on maize yields under low nitrogen input conditions in sub-Saharan Africa.
  • G N Falconnier
  • M Corbeels
  • K J Boote
  • F Affholder
  • M Adam
  • D S MacCarthy
  • A C Ruane
  • C Nendel
  • A M Whitbread
  • E Justes
  • L R Ahuja
  • F M Akinseye
  • I N Alou
  • K A Amouzou
  • S S Anapalli
  • C Baron
  • B Basso
  • F Baudron
  • P Bertuzzi
  • A J Challinor
  • Y Chen
  • D Deryng
  • M L Elsayed
  • B Faye
  • T Gaiser
  • M Galdos
  • S Gayler
  • E Gerardeaux
  • M Giner
  • B Grant
  • G Hoogenboom
  • E S Ibrahim
  • B Kamali
  • K C Kersebaum
  • S H Kim
  • M van der Laan
  • L Leroux
  • J I Lizaso
  • B Maestrini
  • E A Meier
  • F Mequanint
  • A Ndoli
  • C H Porter
  • E Priesack
  • D Ripoche
  • T Sida
  • U Singh
  • W Smith
  • A Srivastava
  • S Sinha
  • F Tao
  • P J Thorburn
  • D Timlin
  • B Traore
  • T Twine
  • H Webber
  • Glob Chang Biol.2020 Jul;doi: 10.1111/gcb.15261.Epub 2020-07-06.

膀胱癌に対する根治的膀胱摘出術後の補助化学療法のタイミングが患者の生存に及ぼす影響

Impact of timing of adjuvant chemotherapy following radical cystectomy for bladder cancer on patient survival.
  • Camilla M Grunewald
  • Alina Henn
  • Matthew D Galsky
  • Elizabeth R Plimack
  • Lauren C Harshman
  • Evan Y Yu
  • Simon J Crabb
  • Sumanta K Pal
  • Ajjai Shivaram Alva
  • Thomas Powles
  • Ugo De Giorgi
  • Neeraj Agarwal
  • Aristotelis Bamias
  • Sylvain Ladoire
  • Andrea Necchi
  • Ulka N Vaishampayan
  • Cora N Sternberg
  • Joaquim Bellmunt
  • Jack Baniel
  • Guenter Niegisch
  • Urol. Oncol..2020 Jul;S1078-1439(20)30276-3. doi: 10.1016/j.urolonc.2020.06.008.Epub 2020-07-10.

NPHS1およびTNFSF15における共通のリスクバリアントは、小児ステロイド感受性ネフローゼ症候群と関連している

Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome.
  • Xiaoyuan Jia
  • Tomohiko Yamamura
  • Rasheed Gbadegesin
  • Michelle T McNulty
  • Kyuyong Song
  • China Nagano
  • Yuki Hitomi
  • Dongwon Lee
  • Yoshihiro Aiba
  • Seik-Soon Khor
  • Kazuko Ueno
  • Yosuke Kawai
  • Masao Nagasaki
  • Eisei Noiri
  • Tomoko Horinouchi
  • Hiroshi Kaito
  • Riku Hamada
  • Takayuki Okamoto
  • Koichi Kamei
  • Yoshitsugu Kaku
  • Rika Fujimaru
  • Ryojiro Tanaka
  • Yuko Shima
  • Jiwon Baek
  • Hee Gyung Kang
  • Il-Soo Ha
  • Kyoung Hee Han
  • Eun Mi Yang
  • Asiri Abeyagunawardena
  • Brandon Lane
  • Megan Chryst-Stangl
  • Christopher Esezobor
  • Adaobi Solarin
  • Claire Dossier
  • Georges Deschênes
  • Marina Vivarelli
  • Hanna Debiec
  • Kenji Ishikura
  • Masafumi Matsuo
  • Kandai Nozu
  • Pierre Ronco
  • Hae Il Cheong
  • Matthew G Sampson
  • Katsushi Tokunaga
  • Kazumoto Iijima
  • Kidney Int..2020 Jun;S0085-2538(20)30639-6. doi: 10.1016/j.kint.2020.05.029.Epub 2020-06-14.

HIV 感染症患者におけるグローバルな炎症マーカーとして H-NMR で評価された糖タンパク質プロファイル。プロスペクティブ研究

Glycoprotein Profile Assessed by H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study.
  • Ana-Irene Malo
  • Anna Rull
  • Josefa Girona
  • Pere Domingo
  • Rocío Fuertes-Martín
  • Núria Amigó
  • Cèlia Rodríguez-Borjabad
  • Neus Martínez-Micaelo
  • Manuel Leal
  • Joaquim Peraire
  • Xavier Correig
  • Francesc Vidal
  • Lluis Masana
  • J Clin Med.2020 May;9(5). E1344. doi: 10.3390/jcm9051344.Epub 2020-05-04.