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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

神経障害の症状と変化.遺伝性トランスサイレチンアミロイドーシスに対するイノテルセン治療

Neuropathy Symptom and Change: Inotersen Treatment of Hereditary Transthyretin Amyloidosis.
  • P James B Dyck
  • Teresa Coelho
  • Marcia Waddington Cruz
  • Thomas H Brannagan
  • Sami Khella
  • Chafic Karam
  • John L Berk
  • Michael J Polydefkis
  • John C Kincaid
  • Janice F Wiesman
  • William J Litchy
  • Michelle L Mauermann
  • Elizabeth J Ackermann
  • Brenda F Baker
  • Shiangtung W Jung
  • Spencer Guthrie
  • Michael Pollock
  • Peter J Dyck
  • Muscle Nerve.2020 Jul;doi: 10.1002/mus.27023.Epub 2020-07-12.

タンブリンは、Zanthoxylum armatum DCの果実のメタノール抽出物の主要な活性化合物であり、サイクリックAMPとサイクリックGMPの弛緩経路を介して、ブタの冠動脈輪の内皮非依存性弛緩を引き起こします

Tambulin is a major active compound of a methanolic extract of fruits of Zanthoxylum armatum DC causing endothelium-independent relaxations in porcine coronary artery rings via the cyclic AMP and cyclic GMP relaxing pathways.
  • Muhammad Naveed Mushtaq
  • Sushmita Ghimire
  • Alamgeer
  • Muhammad Shoaib Akhtar
  • Achyut Adhikari
  • Cyril Auger
  • Valérie B Schini-Kerth
  • Phytomedicine.2019 Feb;53:163-170. S0944-7113(18)30301-5. doi: 10.1016/j.phymed.2018.09.020.Epub 2018-09-05.

主な単発性自己炎症性疾患とPFAPA症候群に対する現在の治療選択肢.エビデンスに基づいたアプローチと実践ガイドの提案

Current Therapeutic Options for the Main Monogenic Autoinflammatory Diseases and PFAPA Syndrome: Evidence-Based Approach and Proposal of a Practical Guide.
  • Alessandra Soriano
  • Marco Soriano
  • Gerard Espinosa
  • Raffaele Manna
  • Giacomo Emmi
  • Luca Cantarini
  • José Hernández-Rodríguez
  • Front Immunol.2020;11:865. doi: 10.3389/fimmu.2020.00865.Epub 2020-06-03.

心房細動のタイプ、心不全、高齢と心房細動における左房血栓のリスクとの関連としての左房付属器空輸速度の低下

Decreased left atrial appendage emptying velocity as a link between atrial fibrillation type, heart failure and older age and the risk of left atrial thrombus in atrial fibrillation.
  • Monika Gawałko
  • Monika Budnik
  • Beata Uziębło-Życzkowska
  • Paweł Krzesiński
  • Piotr Scisło
  • Janusz Kochanowski
  • Agnieszka Jurek
  • Marek Kiliszek
  • Grzegorz Gielerak
  • Krzysztof J Filipiak
  • Grzegorz Opolski
  • Agnieszka Kapłon-Cieślicka
  • Int. J. Clin. Pract..2020 Jul;:e13609. doi: 10.1111/ijcp.13609.Epub 2020-07-12.

エンテロバクターA47が分泌する細菌性フコース多糖類をベースとした銀ナノコンポジットの創傷被覆用途への応用。合成、特性評価およびin vitro生物活性

Silver nanocomposites based on the bacterial fucose-rich polysaccharide secreted by Enterobacter A47 for wound dressing applications: Synthesis, characterization and in vitro bioactivity.
  • Patrícia Concórdio-Reis
  • Carolina V Pereira
  • Miguel P Batista
  • Chantal Sevrin
  • Christian Grandfils
  • Ana C Marques
  • Elvira Fortunato
  • Frédéric B Gaspar
  • Ana A Matias
  • Filomena Freitas
  • Maria A M Reis
  • Int. J. Biol. Macromol..2020 Jul;S0141-8130(20)33823-X. doi: 10.1016/j.ijbiomac.2020.07.072.Epub 2020-07-09.

慢性膵炎の管理における診断用内視鏡超音波の役割に関する国際コンセンサスガイドライン。国際膵臓学会、米国膵臓学会、日本膵臓学会、欧州膵臓クラブとの協力による慢性膵炎の国際コンセンサスガイドラインのワーキンググループからの勧告

International consensus guidelines on the role of diagnostic endoscopic ultrasound in the management of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club.
  • C Mel Wilcox
  • Thomas Gress
  • Marja Boermeester
  • Atsushi Masamune
  • Philippe Lévy
  • Takao Itoi
  • Shyam Varadarajulu
  • Atsushi Irisawa
  • Michael Levy
  • Masayuki Kitano
  • Pramod Garg
  • Shuiji Isaji
  • Tooru Shimosegawa
  • Andrea R G Sheel
  • David C Whitcomb
  • John P Neoptolemos
  • Pancreatology.2020 Jun;S1424-3903(20)30203-9. doi: 10.1016/j.pan.2020.05.025.Epub 2020-06-18.

ニセサンゴヘビRhinobothryum bovallii (Andersson, 1916)のデュベルノワ腺分泌のベノミクスとシナプスおよびダイアプス動物モデルに対する毒致死性の評価

Venomics of the Duvernoy's gland secretion of the false coral snake Rhinobothryum bovallii (Andersson, 1916) and assessment of venom lethality towards synapsid and diapsid animal models.
  • Juan J Calvete
  • Fabián Bonilla
  • Sofía Granados-Martínez
  • Libia Sanz
  • Bruno Lomonte
  • Mahmood Sasa
  • J Proteomics.2020 Jun;225:103882. S1874-3919(20)30250-5. doi: 10.1016/j.jprot.2020.103882.Epub 2020-06-27.

健康な被験者を対象とした身体活動および熱処理中のリドカイン外用システム1.8%の無作為化、クロスオーバー、薬物動態および付着性能に関する研究

A Randomized, Crossover, Pharmacokinetic and Adhesion Performance Study of a Lidocaine Topical System 1.8% During Physical Activity and Heat Treatment in Healthy Subjects.
  • Jeffrey Fudin
  • Erica L Wegrzyn
  • Emileigh Greuber
  • Kip Vought
  • Kalpana Patel
  • Sri Nalamachu
  • J Pain Res.2020;13:1359-1367. 238268. doi: 10.2147/JPR.S238268.Epub 2020-06-10.

固定矯正治療を受けている患者の口腔内健康維持におけるプロバイオティクスの役割:無作為化対照臨床試験の系統的レビュー

Role of Probiotics in Oral Health Maintenance Among Patients Undergoing Fixed Orthodontic Therapy: a Systematic Review of Randomized Controlled Clinical Trials.
  • Francesca Katherine Pietri
  • P Emile Rossouw
  • Fawad Javed
  • Dimitrios Michelogiannakis
  • Probiotics Antimicrob Proteins.2020 Jul;10.1007/s12602-020-09683-2. doi: 10.1007/s12602-020-09683-2.Epub 2020-07-04.

バイオベースのポリブチレンサクシネート/微結晶セルロース/ナノフィブリル化セルロースベースの持続可能な高分子複合材料。熱力学的および生分解に関する研究

Bio-Based Poly(butylene succinate)/Microcrystalline Cellulose/Nanofibrillated Cellulose-Based Sustainable Polymer Composites: Thermo-Mechanical and Biodegradation Studies.
  • Oskars Platnieks
  • Sergejs Gaidukovs
  • Anda Barkane
  • Aleksandrs Sereda
  • Gerda Gaidukova
  • Liga Grase
  • Vijay Kumar Thakur
  • Inese Filipova
  • Velta Fridrihsone
  • Marite Skute
  • Marianna Laka
  • Polymers (Basel).2020 Jun;12(7). E1472. doi: 10.3390/polym12071472.Epub 2020-06-30.

20nm以下のギャップを持つ2次元周期プラズモニック有限アレイからの高透過率をGa FIBミリングで実現しました

High transmission from 2D periodic plasmonic finite arrays with sub-20-nm gaps realized with Ga FIB milling.
  • Filippo Pisano
  • Antonio Balena
  • Muhammad Fayyaz Kashif
  • Marco Pisanello
  • Gaia De Marzo
  • Luciana Algieri
  • Antonio Qualtieri
  • Leonardo Sileo
  • Tiziana Stomeo
  • Antonella D'Orazio
  • Massimo De Vittorio
  • Ferruccio Pisanello
  • Marco Grande
  • Nanotechnology.2020 Jul;doi: 10.1088/1361-6528/aba57a.Epub 2020-07-13.

1990年から2017年のイランにおける筋骨格系疾患の負担:世界疾病負担調査2017からの推計

Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017.
  • M Shahrezaee
  • S Keshtkari
  • M Moradi-Lakeh
  • M Abbasifard
  • V Alipour
  • S Amini
  • J Arabloo
  • A Arzani
  • M Bakhshaei
  • A Barzegar
  • A Bijani
  • M Dianatinasab
  • S Eskandarieh
  • R Ghanei Gheshlagh
  • A Ghashghaee
  • R Heidari-Soureshjani
  • S S N Irvani
  • A Lahimchi
  • S Maleki
  • N Manafi
  • A Manafi
  • M A Mansournia
  • A Mohammadian-Hafshejani
  • M A Mohseni Bandpei
  • R Moradzadeh
  • M Naderi
  • K Pakshir
  • A Rafiei
  • V Rashedi
  • N Rezaei
  • A Rezapour
  • M A Sahraian
  • S Shahabi
  • M Shamsi
  • A Soheili
  • A Soroush
  • M Zamani
  • B Mohajer
  • F Farzadfar
  • Arch Osteoporos.2020 Jul;15(1):103. 10.1007/s11657-020-00767-8. doi: 10.1007/s11657-020-00767-8.Epub 2020-07-10.

C 型肝炎に対する直接作用型抗ウイルス治療後の非アルコール性脂肪肝疾患のリスク因子は、肝臓関連転帰に影響します

Nonalcoholic Fatty Liver Disease Risk Factors Affect Liver-Related Outcomes After Direct-Acting Antiviral Treatment for Hepatitis C.
  • Jihane N Benhammou
  • Andrew M Moon
  • Joseph R Pisegna
  • Feng Su
  • Philip Vutien
  • Cynthia A Moylan
  • George N Ioannou
  • Dig. Dis. Sci..2020 Jul;10.1007/s10620-020-06457-2. doi: 10.1007/s10620-020-06457-2.Epub 2020-07-11.

思春期の特発性側弯症と側弯症のない思春期の成長期における台骨形態学的および神経血管解剖学的な進行性変化の特徴付け

Characterization of progressive changes in pedicle morphometry and neurovascular anatomy during growth in adolescent idiopathic scoliosis versus adolescents without scoliosis.
  • Colin M Davis
  • Caroline A Grant
  • Maree T Izatt
  • Geoffrey N Askin
  • Robert D Labrom
  • Clayton J Adam
  • Mark J Pearcy
  • J Paige Little
  • Spine Deform.2020 Jun;10.1007/s43390-020-00160-y. doi: 10.1007/s43390-020-00160-y.Epub 2020-06-17.

ラットにおける7,12-ジメチルベンザアントラセンによる肺機能障害に対するビタミンK栄養補助食品の効果

Effects of vitamin K dietary supplementation in pulmonary dysfunction induced by 7,12-dimethylbenz[a]anthracene in rat.
  • Oluwatosin A Dosumu
  • Solomon O Rotimi
  • Jacob Akintunde
  • Oluwagbemiga O Adeleye
  • Latifah O Sani
  • Oluwatosin O Omotosho
  • Kehinde T Osinuga
  • Odunayo A Taiwo
  • Oluwafemi A Ojo
  • J. Biochem. Mol. Toxicol..2020 Jul;:e22584. doi: 10.1002/jbt.22584.Epub 2020-07-14.

進行性肝線維症を有する HCV GEN3 患者における高い持続性ウイルス反応:ジョージア州における HCV 排除プログラムの実世界のデータ

High sustained viral response among HCV genotype 3 patients with advanced liver fibrosis: real-world data of HCV elimination program in Georgia.
  • Maia Butsashvili
  • Lia Gvinjilia
  • George Kamkamidze
  • David Metreveli
  • Shorena Dvali
  • Tamar Rukhadze
  • Amiran Gamkrelidze
  • Muazzam Nasrullah
  • Shaun Shadaker
  • Juliette Morgan
  • Francisco Averhoff
  • BMC Res Notes.2020 Jul;13(1):332. 10.1186/s13104-020-05173-4. doi: 10.1186/s13104-020-05173-4.Epub 2020-07-11.

病原性ストレス下での金貝と褐色貴貝の間で、πクラスのグルタチオンSトランスフェラーゼ(CnGSTp)の発現と抗酸化状態の応答が異なる

Differential responses of a pi-class glutathione S-transferase (CnGSTp) expression and antioxidant status between golden and brown noble scallops under pathogenic stress.
  • Hongxing Liu
  • Hongkuan Zhang
  • Dewei Cheng
  • Karsoon Tan
  • Ting Ye
  • Hongyu Ma
  • Shengkang Li
  • Huaiping Zheng
  • Fish Shellfish Immunol..2020 Jul;S1050-4648(20)30488-5. doi: 10.1016/j.fsi.2020.07.004.Epub 2020-07-08.

COVID-19パンデミックが若年者および成人の精神的健康に及ぼす影響:観察研究のシステマティックレビュープロトコル

Impact of COVID-19 pandemic on mental health of young people and adults: a systematic review protocol of observational studies.
  • Fernando Jose Guedes da Silva Junior
  • Jaqueline Carvalho E Silva Sales
  • Claudete Ferreira de Souza Monteiro
  • Ana Paula Cardoso Costa
  • Luana Ruth Braga Campos
  • Priscilla Ingrid Gomes Miranda
  • Thiago Alberto de Souza Monteiro
  • Regina Aparecida Garcia Lima
  • Luis Carlos Lopes-Junior
  • BMJ Open.2020 Jul;10(7):e039426. bmjopen-2020-039426. doi: 10.1136/bmjopen-2020-039426.Epub 2020-07-01.

脳神経スルホトランスフェラーゼの基質となるセレブロシド類似体の合成と構造活性相関、および競合的阻害剤の発見

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor.
  • Wenjin Li
  • Joren Guillaume
  • Younis Baqi
  • Isabell Wachsmann
  • Volkmar Gieselmann
  • Serge Van Calenbergh
  • Christa E Müller
  • J Enzyme Inhib Med Chem.2020 Dec;35(1):1503-1512. doi: 10.1080/14756366.2020.1791841.

上気道刺激対陽性気道圧治療難治性の閉塞性睡眠時無呼吸症候群の未治療比較例

Upper Airway Stimulation versus Untreated Comparators in Positive Airway Pressure Treatment Refractory Obstructive Sleep Apnea.
  • Reena Mehra
  • Armin Steffen
  • Clemens Heiser
  • Benedikt Hofauer
  • Kirk Withrow
  • Karl Doghramji
  • Maurits Boon
  • Colin Huntley
  • Ryan J Soose
  • Suzanne Stevens
  • Chris Larsen
  • Joachim T Maurer
  • Tina Waters
  • Harneet K Walia
  • Alan H Kominsky
  • Doug Trask
  • Richard J Schwab
  • Erica R Thaler
  • Patrick J Strollo
  • Ann Am Thorac Soc.2020 Jul;doi: 10.1513/AnnalsATS.202001-015OC.Epub 2020-07-14.

民間人による病院前出血管理のための研究アジェンダの定義。コンセンサス・ステートメント

Defining a Research Agenda for Layperson Prehospital Hemorrhage Control: A Consensus Statement.
  • Eric Goralnick
  • Chibuike Ezeibe
  • Muhammad Ali Chaudhary
  • Justin McCarty
  • Juan P Herrera-Escobar
  • Tomas Andriotti
  • Elzerie de Jager
  • Daniel Ospina-Delgado
  • Craig Goolsby
  • Richard Hunt
  • Joel S Weissman
  • Adil Haider
  • Lenworth Jacobs
  • Erin Andrade
  • Jeremy Brown
  • Eileen M Bulger
  • Frank K Butler
  • David Callaway
  • Edward J Caterson
  • Niteesh K Choudhry
  • Michael R Davis
  • Alex Eastman
  • Brian J Eastridge
  • Jonathan L Epstein
  • Conor L Evans
  • Marianne Gausche-Hill
  • Mark L Gestring
  • Scott A Goldberg
  • Dan Hanfling
  • John Bradley Holcomb
  • Carl-Oscar Jonson
  • David R King
  • Sean Kivlehan
  • Russ S Kotwal
  • Jon R Krohmer
  • Nomi Levy-Carrick
  • Matthew Levy
  • Joan José Meléndez Lugo
  • David P Mooney
  • Matthew D Neal
  • Robert Niskanen
  • Patrick O'Neill
  • Habeeba Park
  • Peter T Pons
  • Erik Prytz
  • Todd E Rasmussen
  • Michael A Remley
  • Robert Riviello
  • Ali Salim
  • Stacy Shackelfold
  • E Reed Smith
  • Ronald M Stewart
  • Mamta Swaroop
  • Kevin Ward
  • Tarsicio Uribe-Leitz
  • Molly P Jarman
  • Gezzer Ortega
  • JAMA Netw Open.2020 Jul;3(7):e209393. 2767879. doi: 10.1001/jamanetworkopen.2020.9393.Epub 2020-07-01.

ハイリスク冠動脈疾患患者における未診断の腹部大動脈瘤および亜動脈瘤性大動脈拡張の早期発見。標的型スクリーニングプログラムの価値

Early Detection of Undiagnosed Abdominal Aortic Aneurysm and Sub-Aneurysmal Aortic Dilatations in Patients with High-Risk Coronary Artery Disease: The Value of Targetted Screening Programme.
  • Siong Teng Saw
  • Benjamin Dak Keung Leong
  • Dayang Anita Abdul Aziz
  • Vasc Health Risk Manag.2020;16:215-229. 250735. doi: 10.2147/VHRM.S250735.Epub 2020-06-09.

(Nees)Mezの抽出物とフラクション。化学的特性、抗活性および関連する作用機序

(Nees) Mez Extract and Fractions: Chemical Characterization, Anti- Activity and Related Mechanism of Action.
  • Mayara Nunes Vitor Anjos
  • Luiz Nascimento de Araújo-Neto
  • Maria Daniela Silva Buonafina
  • Rejane Pereira Neves
  • Edson Rubhens de Souza
  • Isabelle Cristinne Ferraz Bezerra
  • Magda Rhayanny Assunção Ferreira
  • Luiz Alberto Lira Soares
  • Henrique Douglas Melo Coutinho
  • Natália Martins
  • Márcia Vanusa da Silva
  • Maria Tereza Dos Santos Correia
  • Antibiotics (Basel).2020 Jul;9(7). E394. doi: 10.3390/antibiotics9070394.Epub 2020-07-09.

白斑患者におけるホモシステインレベルとメチレンテトラヒドロ葉酸還元酵素(MTHFR)遺伝子およびシスタチオニンB合成酵素(CBS)遺伝子多型の推定

Estimation of Homocysteine Level and Methylenetetrahydrofolate Reductase (MTHFR) Gene and Cystathionine B Synthase (CBS) Gene Polymorphisms in Vitiligo Patients.
  • Samar El Tahlawi
  • Dalia M Abdel Halim
  • Heba El Hadidi
  • Marwa M Fawzy
  • Rehab A Hegazy
  • Marwa Ezzat
  • Sherin M Elgohary
  • Olfat Shaker
  • Khadiga S Sayed
  • Skin Pharmacol Physiol.2020;33(1):38-43. 000504235. doi: 10.1159/000504235.Epub 2019-11-28.

アレルギー性鼻炎における鼻腔内一酸化窒素測定の臨床応用。システマティックレビューとメタアナリシス

Clinical application of nasal nitric oxide measurement in allergic rhinitis: A systematic review and meta-analysis.
  • Pasquale Ambrosino
  • Paolo Parrella
  • Roberto Formisano
  • Antimo Papa
  • Giorgio Alfredo Spedicato
  • Matteo Nicola Dario Di Minno
  • Andrea Motta
  • Mauro Maniscalco
  • Ann. Allergy Asthma Immunol..2020 Jul;S1081-1206(20)30479-8. doi: 10.1016/j.anai.2020.07.003.Epub 2020-07-11.

9~15 歳の女児および男児における 9 価ヒトパピローマウイルスワクチンの長期的な免疫原性、有効性、安全性:8 年間の追跡調査後の中間解析

Long-term immunogenicity, effectiveness, and safety of nine-valent human papillomavirus vaccine in girls and boys 9 to 15 years of age: Interim analysis after 8 years of follow-up.
  • Sven-Eric Olsson
  • Jaime Alberto Restrepo
  • Julio Cesar Reina
  • Punnee Pitisuttithum
  • Angels Ulied
  • Meera Varman
  • Pierre Van Damme
  • Edson Duarte Moreira
  • Daron Ferris
  • Stanley Block
  • Oliver Bautista
  • Nancy Gallagher
  • Jennifer McCauley
  • Alain Luxembourg
  • Papillomavirus Res.2020 Jul;:100203. S2405-8521(20)30021-5. doi: 10.1016/j.pvr.2020.100203.Epub 2020-07-10.

外科的切除がステージ4の高リスク神経芽細胞腫患者の生存に及ぼす影響:HR-NBL1/SIOPEN試験からの報告

Influence of Surgical Excision on the Survival of Patients With Stage 4 High-Risk Neuroblastoma: A Report From the HR-NBL1/SIOPEN Study.
  • Keith Holmes
  • Ulrike Pötschger
  • Andrew D J Pearson
  • Sabine Sarnacki
  • Giovanni Cecchetto
  • Javier Gomez-Chacon
  • Roly Squire
  • Enrique Freud
  • Adam Bysiek
  • Lucas E Matthyssens
  • Martin Metzelder
  • Tom Monclair
  • Jakob Stenman
  • Michal Rygl
  • Lars Rasmussen
  • Jean-Marc Joseph
  • Sabine Irtan
  • Stefano Avanzini
  • Jan Godzinski
  • Kristin Björnland
  • Martin Elliott
  • Roberto Luksch
  • Victoria Castel
  • Shifra Ash
  • Walentyna Balwierz
  • Geneviève Laureys
  • Ellen Ruud
  • Vassilios Papadakis
  • Josef Malis
  • Cormac Owens
  • Henrik Schroeder
  • Maja Beck-Popovic
  • Toby Trahair
  • Ana Forjaz de Lacerda
  • Peter F Ambros
  • Mark N Gaze
  • Kieran McHugh
  • Dominique Valteau-Couanet
  • Ruth Lydia Ladenstein
  • J. Clin. Oncol..2020 Jul;:JCO1903117. doi: 10.1200/JCO.19.03117.Epub 2020-07-08.

乳酸アシドーシスを伴うミトコンドリア脳筋症、脳卒中様エピソード症候群を呈した1例のミトコンドリアDNA 10158T>C変異。症例報告と文献レビュー(CARE-complaint).

Mitochondrial DNA 10158T>C mutation in a patient with mitochondrial encephalomyopathy with lactic acidosis, and stroke-like episodes syndrome: A case-report and literature review (CARE-complaint).
  • Shuai Wang
  • Tao Song
  • Suping Wang
  • Medicine (Baltimore).2020 Jun;99(24):e20310. 00005792-202006120-00010. doi: 10.1097/MD.0000000000020310.

ニコチンアミド・アデニン・ジヌクレオチド・リン酸経路におけるTKTとDRAの遺伝子変異がメラノーマの生存を予測した

Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival.
  • Ning Gu
  • Wei Dai
  • Hongliang Liu
  • Jie Ge
  • Sheng Luo
  • Eunyoung Cho
  • Christopher I Amos
  • Jeffrey E Lee
  • Xin Li
  • Hongmei Nan
  • Hua Yuan
  • Qingyi Wei
  • Eur. J. Cancer.2020 Jul;136:84-94. S0959-8049(20)30283-5. doi: 10.1016/j.ejca.2020.04.049.Epub 2020-07-09.

在来肝を有するα-1-アントリプシン欠乏症の若年患者の縦断的転帰から、新生児のコレスタシスは将来の門脈圧亢進の不良な予測因子であることが明らかになった

Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension.
  • Jeffrey Teckman
  • Philip Rosenthal
  • Kieran Hawthorne
  • Cathie Spino
  • Lee M Bass
  • Karen F Murray
  • Nanda Kerkar
  • John C Magee
  • Saul Karpen
  • James E Heubi
  • Jean P Molleston
  • Robert H Squires
  • Binita M Kamath
  • Stephen L Guthery
  • Kathleen M Loomes
  • Averell H Sherker
  • Ronald J Sokol
  • J. Pediatr..2020 Jul;S0022-3476(20)30874-X. doi: 10.1016/j.jpeds.2020.07.031.Epub 2020-07-11.

温帯林では、不均一性と多様性の関係は、栄養段階間および栄養段階内で異なっている

Heterogeneity-diversity relationships differ between and within trophic levels in temperate forests.
  • Lea Heidrich
  • Soyeon Bae
  • Shaun Levick
  • Sebastian Seibold
  • Wolfgang Weisser
  • Peter Krzystek
  • Paul Magdon
  • Thomas Nauss
  • Peter Schall
  • Alla Serebryanyk
  • Stephan Wöllauer
  • Christian Ammer
  • Claus Bässler
  • Inken Doerfler
  • Markus Fischer
  • Martin M Gossner
  • Marco Heurich
  • Torsten Hothorn
  • Kirsten Jung
  • Holger Kreft
  • Ernst-Detlef Schulze
  • Nadja Simons
  • Simon Thorn
  • Jörg Müller
  • Nat Ecol Evol.2020 Jul;10.1038/s41559-020-1245-z. doi: 10.1038/s41559-020-1245-z.Epub 2020-07-13.

ブロモドメイン選択的BET阻害剤は、MYC駆動の小児がんに対する強力な抗腫瘍剤である

Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer.
  • P Jake Slavish
  • Liying Chi
  • Mi-Kyung Yun
  • Lyudmila Tsurkan
  • Nancy E Martinez
  • Barbara Jonchere
  • Sergio C Chai
  • Michele Connelly
  • M Brett Waddell
  • Sourav Das
  • Geoffrey Neale
  • Zhenmei Li
  • William R Shadrick
  • Rachelle R Olsen
  • Kevin W Freeman
  • Jonathan A Low
  • Jeanine E Price
  • Brandon M Young
  • Nagakumar Bharatham
  • Vincent A Boyd
  • Jun Yang
  • Richard E Lee
  • Marie Morfouace
  • Martine F Roussel
  • Taosheng Chen
  • Daniel Savic
  • R Kiplin Guy
  • Stephen W White
  • Anang A Shelat
  • Philip M Potter
  • Cancer Res..2020 Jul;canres.3934.2019. doi: 10.1158/0008-5472.CAN-19-3934.Epub 2020-07-10.

将来の電子タバコ使用を予測する上で、自己申告喫煙と比較したバイオマーカーの付加価値を調査しています。英国の縦断的コホート研究からのエビデンス

Investigating the added value of biomarkers compared with self-reported smoking in predicting future e-cigarette use: Evidence from a longitudinal UK cohort study.
  • Jasmine N Khouja
  • Marcus R Munafò
  • Caroline L Relton
  • Amy E Taylor
  • Suzanne H Gage
  • Rebecca C Richmond
  • PLoS ONE.2020;15(7):e0235629. PONE-D-20-06112. doi: 10.1371/journal.pone.0235629.Epub 2020-07-14.

北マケドニア共和国の女性におけるTNF-a(rs361525およびrs1800629)と子宮頸部上皮内病変および子宮頸部癌に対する感受性との関連

Association of TNF-a (rs361525 and rs1800629) with susceptibility to cervical intraepithelial lesion and cervical carcinoma in women from Republic of North Macedonia.
  • Sotirija Duvlis
  • Drage Dabeski
  • Aleksandar Cvetkovski
  • Kristina Mladenovska
  • Dijana Plaseska-Karanfilska
  • Int. J. Immunogenet..2020 Jul;doi: 10.1111/iji.12506.Epub 2020-07-14.

フェナリモールのラットへの経口投与および静脈内投与後の血漿タンパク質結合、代謝、反応表現型および毒物動態学的研究

Plasma protein binding, metabolism, reaction phenotyping and toxicokinetic studies of fenarimol after oral and intravenous administration in rats.
  • Kajal Karsauliya
  • Ashish Kumar Sonker
  • Manisha Bhateria
  • Isha Taneja
  • Anshuman Srivastava
  • Manu Sharma
  • Sheelendra Pratap Singh
  • Xenobiotica.2020 Jul;:1-32. doi: 10.1080/00498254.2020.1796170.Epub 2020-07-14.

High INtensity Interval Training In pATiEnts with intermittent claudication(INITIATE):多施設、概念実証済み、前向き介入研究のプロトコル

High INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multicentre, proof-of-concept, prospective interventional study.
  • Sean Pymer
  • Amy Harwood
  • Said Ibeggazene
  • Gordon McGregor
  • Chao Huang
  • Maureen Twiddy
  • Adam R Nicholls
  • Lee Ingle
  • Sean Carroll
  • Judith Long
  • Marjorie Rooms
  • I C Chetter
  • BMJ Open.2020 Jul;10(7):e038825. bmjopen-2020-038825. doi: 10.1136/bmjopen-2020-038825.Epub 2020-07-06.

中国雲南省のミャンマーとアフリカから分離されたPlasmodium ovale curtisiとPlasmodium ovale wallikeriの原感染株におけるk13遺伝子のプロペラドメインの多型解析

Polymorphism analysis of propeller domain of k13 gene in Plasmodium ovale curtisi and Plasmodium ovale wallikeri isolates original infection from Myanmar and Africa in Yunnan Province, China.
  • Mengni Chen
  • Ying Dong
  • Yan Deng
  • Yanchun Xu
  • Yan Liu
  • Canglin Zhang
  • Herong Huang
  • Malar. J..2020 Jul;19(1):246. 10.1186/s12936-020-03317-2. doi: 10.1186/s12936-020-03317-2.Epub 2020-07-13.

多重マイクロ流体ループ媒介等温増幅法と視覚的検出法による30種類の皮膚ヒトパピローマウイルスの遺伝子型解析を行った

Genotyping of 30 kinds of cutaneous human papillomaviruses by a multiplex microfluidic loop-mediated isothermal amplification and visual detection method.
  • Yining Wang
  • Ge Ge
  • Rui Mao
  • Zhuo Wang
  • Yu-Zhe Sun
  • Yu-Guang Du
  • Xing-Hua Gao
  • Rui-Qun Qi
  • Hong-Duo Chen
  • Virol. J..2020 Jul;17(1):99. 10.1186/s12985-020-01373-3. doi: 10.1186/s12985-020-01373-3.Epub 2020-07-09.

超高性能液体クロマトグラフィーとエレクトロスプレーイオン化四重極飛行時間型タンデム質量分析法を組み合わせた超高性能液体クロマトグラフィーを用いたラットのin vitro/in vivoにおけるチェレリスリンおよびジヒドロチェレリスリンの代謝物同定および可逆的な相互変換

Metabolites identification and reversible interconversion of chelerythrine and dihydrochelerythrine in vitro/in vivo in rats using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
  • Qiyan Lin
  • Chao Ma
  • Huida Guan
  • Liangni Chen
  • Qi Xie
  • Xuemei Cheng
  • Changhong Wang
  • J Pharm Biomed Anal.2020 Jul;189:113462. S0731-7085(20)31348-0. doi: 10.1016/j.jpba.2020.113462.Epub 2020-07-07.

腸内マイクロバイオームの安定性は、プロバイオティクスの摂取によって変化し、ガラクトオリゴ糖の継続的な補給によって改善される

The gut microbiome stability is altered by probiotic ingestion and improved by the continuous supplementation of galactooligosaccharide.
  • Chenchen Ma
  • Sanjeev Wasti
  • Shi Huang
  • Zeng Zhang
  • Rajeev Mishra
  • Shuaiming Jiang
  • Zhengkai You
  • Yixuan Wu
  • Haibo Chang
  • Yuanyuan Wang
  • Dongxue Huo
  • Congfa Li
  • Zhihong Sun
  • Zheng Sun
  • Jiachao Zhang
  • Gut Microbes.2020 Jul;:1-13. doi: 10.1080/19490976.2020.1785252.Epub 2020-07-14.

高齢男性における脳出血,脳梗塞,特定不能脳卒中の口腔保健と心血管疾患の危険因子と死亡率.プロスペクティブコホート研究

Oral health and cardiovascular disease risk factors and mortality of cerebral haemorrhage, cerebral infarction and unspecified stroke in elderly men: A prospective cohort study.
  • Lise Lund Håheim
  • Per Nafstad
  • Per E Schwarze
  • Ingar Olsen
  • Kjersti S Rønningen
  • Dag S Thelle
  • Scand J Public Health.2019 Dec;:1403494819879351. doi: 10.1177/1403494819879351.Epub 2019-12-08.

ゲラニルゲラニルアセトンは、ミトコンドリア膜電位を上昇させることで、HT-22細胞におけるグルタミン酸誘発細胞死を抑制する

Geranylgeranyl acetone prevents glutamate-induced cell death in HT-22 cells by increasing mitochondrial membrane potential.
  • Eriko Sugano
  • Yuka Endo
  • Akihisa Sugai
  • Yuki Kikuchi
  • Kitako Tabata
  • Taku Ozaki
  • Takahiro Kurose
  • Yoshihiro Takai
  • Yoko Mistsuguchi
  • Yoichi Honma
  • Hiroshi Tomita
  • Eur. J. Pharmacol..2020 Jul;:173193. S0014-2999(20)30285-5. doi: 10.1016/j.ejphar.2020.173193.Epub 2020-07-10.

インターロイキン1受容体1のノックアウトと母体の高脂肪食暴露は、成人マウスの子孫の脂肪組織の脂肪原性および炎症性遺伝子発現に対する性差効果を誘導する

Interleukin 1 Receptor 1 Knockout and Maternal High Fat Diet Exposure Induces Sex-Specific Effects on Adipose Tissue Adipogenic and Inflammatory Gene Expression in Adult Mouse Offspring.
  • Pania E Bridge-Comer
  • Jasmine F Plows
  • Farha Ramzan
  • Rachna Patel
  • Thashma P Ganapathy
  • Joanna L Stanley
  • Mark H Vickers
  • Clare M Reynolds
  • Front Physiol.2020;11:601. doi: 10.3389/fphys.2020.00601.Epub 2020-06-23.

肺マイコバクテリウム・アビウム複合症の治療におけるフルオロキノロン含有レジメンの有効性と安全性。プロペンシティスコア分析

Efficacy and safety of fluoroquinolone-containing regimens in treating pulmonary Mycobacterium avium complex disease: A propensity score analysis.
  • Hisayuki Shuto
  • Kosaku Komiya
  • Akihiko Goto
  • Takamasa Kan
  • Kokoro Honjo
  • Sonoe Uchida
  • Shuichi Takikawa
  • Tetsuyuki Yoshimatsu
  • Mari Yamasue
  • Kazufumi Hiramatsu
  • Jun-Ichi Kadota
  • PLoS ONE.2020;15(7):e0235797. PONE-D-20-11352. doi: 10.1371/journal.pone.0235797.Epub 2020-07-09.