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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

CTGリピート選択的化学スクリーニングにより、微小管阻害剤が有毒CUG RNAレベルの選択的調節因子として同定された

A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels.
  • Kaalak Reddy
  • Jana R Jenquin
  • Ona L McConnell
  • John D Cleary
  • Jared I Richardson
  • Belinda S Pinto
  • Maja C Haerle
  • Elizabeth Delgado
  • Lori Planco
  • Masayuki Nakamori
  • Eric T Wang
  • J Andrew Berglund
  • Proc. Natl. Acad. Sci. U.S.A..2019 10;116(42):20991-21000. 1901893116. doi: 10.1073/pnas.1901893116.Epub 2019-09-30.

SARS-CoV-2感染後の急性低運動性硬直症候群

Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection.
  • Antonio Méndez-Guerrero
  • María Isabel Laespada-García
  • Adolfo Gómez-Grande
  • Mariano Ruiz-Ortiz
  • Víctor Antonio Blanco-Palmero
  • Francisco Javier Azcarate-Diaz
  • Pablo Rábano-Suárez
  • Eva Álvarez-Torres
  • Carlos Pablo de Fuenmayor-Fernández de la Hoz
  • Diana Vega Pérez
  • Raquel Rodríguez-Montalbán
  • Alfredo Pérez-Rivilla
  • Javier Sayas Catalán
  • Ana Ramos- González
  • Jesús González de la Aleja
  • Neurology.2020 Jul;10.1212/WNL.0000000000010282. doi: 10.1212/WNL.0000000000010282.Epub 2020-07-08.

Baicalinは、RhoA-ROCK経路を介してTh1およびTh17応答を抑制し、Treg応答を促進することで、敗血症に伴う膵臓損傷を改善することが示唆された

Baicalin suppresses Th1 and Th17 responses and promotes Treg response to ameliorate sepsis-associated pancreatic injury via the RhoA-ROCK pathway.
  • Pingping Liu
  • Zhenghui Xiao
  • Haipeng Yan
  • Xiulan Lu
  • Xinping Zhang
  • Lan Luo
  • Caixia Long
  • Yimin Zhu
  • Int. Immunopharmacol..2020 Jun;86:106685. S1567-5769(20)30273-3. doi: 10.1016/j.intimp.2020.106685.Epub 2020-06-19.

単細胞トランスクリプトミクスは、上咽頭癌の予後に関連する免疫細胞の多様性と免疫サブタイプの根底にある制御因子を明らかにした

Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.
  • Yu-Pei Chen
  • Jian-Hua Yin
  • Wen-Fei Li
  • Han-Jie Li
  • Dong-Ping Chen
  • Cui-Juan Zhang
  • Jia-Wei Lv
  • Ya-Qin Wang
  • Xiao-Min Li
  • Jun-Yan Li
  • Pan-Pan Zhang
  • Ying-Qin Li
  • Qing-Mei He
  • Xiao-Jing Yang
  • Yuan Lei
  • Ling-Long Tang
  • Guan-Qun Zhou
  • Yan-Ping Mao
  • Chen Wei
  • Ke-Xu Xiong
  • Hong-Bo Zhang
  • Shi-Da Zhu
  • Yong Hou
  • Ying Sun
  • Michael Dean
  • Ido Amit
  • Kui Wu
  • Dong-Ming Kuang
  • Gui-Bo Li
  • Na Liu
  • Jun Ma
  • Cell Res..2020 Jul;10.1038/s41422-020-0374-x. doi: 10.1038/s41422-020-0374-x.Epub 2020-07-20.

妊娠糖尿病の予測因子としての皮下脂肪および内臓脂肪の超音波評価:システマティックレビュー

Ultrasound evaluation of subcutaneous and visceral abdominal fat as a predictor of gestational diabetes mellitus: a systematic review.
  • Fernanda Teixeira Benevides
  • Edward Araujo Júnior
  • Carla Soraya Costa Maia
  • Renan Magalhães Montenegro Junior
  • Francisco Herlânio Costa Carvalho
  • J. Matern. Fetal. Neonatal. Med..2020 Jun;:1-11. doi: 10.1080/14767058.2020.1781808.Epub 2020-06-21.

Joubert Syndromeにおける網膜電図検査。将来の標的治療の有効性を評価するための提案された客観的方法

Electroretinographic Assessment in Joubert Syndrome: A Suggested Objective Method to Evaluate the Effectiveness of Future Targeted Treatment.
  • Giulio Ruberto
  • Vincenzo Parisi
  • Chiara Bertone
  • Sabrina Signorini
  • Mauro Antonini
  • Enza Maria Valente
  • Federica Manzoni
  • Valentina Serpieri
  • Riccardo Fausto
  • Luciano Quaranta
  • Adv Ther.2020 Jul;10.1007/s12325-020-01432-9. doi: 10.1007/s12325-020-01432-9.Epub 2020-07-15.

ウイルスモニタリングのための磁性誘導性微小電極の設計:B型肝炎ウイルスのためのモデル化と実現可能性

Designing a magnetic inductive micro-electrode for virus monitoring: modelling and feasibility for hepatitis B virus.
  • Elias Alipour
  • Seyed Peyman Shariatpanahi
  • Hedayatollah Ghourchian
  • Benoit Piro
  • Morteza Fathipour
  • Seyed Mehdi Boutorabi
  • Sergey L Znoyko
  • Petr I Nikitin
  • Mikrochim Acta.2020 Jul;187(8):463. 10.1007/s00604-020-04429-x. doi: 10.1007/s00604-020-04429-x.Epub 2020-07-20.

アリニティーm HCVアッセイの性能の多施設臨床評価

Multicenter clinical evaluation of alinity m HCV assay performance.
  • Stéphane Chevaliez
  • Francesco Onelia
  • Monia Pacenti
  • Emily Goldstein
  • Juan-Carlos Galán
  • Laura Martínez-García
  • Alba Vilas
  • Allison Glass
  • Leana Maree
  • Maria Krügel
  • Robert Ehret
  • Heribert Knechten
  • Patrick Braun
  • Gudrun Naeth
  • Sara Bonanzinga
  • Kathy Jackson
  • Klara Abravaya
  • Jens Dhein
  • Shihai Huang
  • Ajith M Joseph
  • Danijela Lucic
  • Natalia Marlowe
  • Michael J Palm
  • Karin Pfeifer
  • Dan Toolsie
  • Birgit Reinhardt
  • Martin Obermeier
  • Rory Gunson
  • J. Clin. Virol..2020 Jul;129:104531. S1386-6532(20)30273-0. doi: 10.1016/j.jcv.2020.104531.Epub 2020-07-03.

MRI陰性の巣状皮質異形成IIB型患者における高度動的統計パラメトリックマッピングと脳磁図法を用いたてんかん原性焦点の検出

Detection of epileptogenic focus using advanced dynamic statistical parametric mapping with magnetoencephalography in a patient with MRI-negative focal cortical dysplasia type IIB.
  • Won Seok Chang
  • Midori Nakajima
  • Ayako Ochi
  • Elysa Widjaja
  • James T Rutka
  • Ivanna Yau
  • Shiro Baba
  • Hiroshi Otsubo
  • J Neurosurg Pediatr.2019 Oct;:1-5. 2019.7.PEDS1948. doi: 10.3171/2019.7.PEDS1948.Epub 2019-10-11.

N-パルミトイル-O-ホスホコリン-セリンとスフィンゴシルホスホリルコリンの同時液体クロマトグラフィー/タンデム質量分析に基づくニーマンピック病の診断スクリーニング法の開発

Development of a diagnostic screening strategy for Niemann-Pick diseases based on simultaneous liquid chromatography/tandem mass spectrometry analyses of N-palmitoyl-O-phosphocholine-serine and sphingosylphosphorylcholine.
  • Anna Iwahori
  • Masamitsu Maekawa
  • Aya Narita
  • Akie Kato
  • Toshihiro Sato
  • Jiro Ogura
  • Yu Sato
  • Masafumi Kikuchi
  • Atsuko Noguchi
  • Katsumi Higaki
  • Torayuki Okuyama
  • Tsutomu Takahashi
  • Yoshikatsu Eto
  • Nariyasu Mano
  • Biol. Pharm. Bull..2020 Jun;doi: 10.1248/bpb.b20-00400.Epub 2020-06-25.

小児、青年、若年成人における薬剤耐性てんかん治療におけるペランパネルの有効性と血清中濃度:12歳未満と12歳以上の患者の比較

Efficacy and serum concentrations of perampanel for treatment of drug-resistant epilepsy in children, adolescents, and young adults: comparison of patients younger and older than 12 years.
  • Satoru Ikemoto
  • Shin-Ichiro Hamano
  • Yuko Hirata
  • Ryuki Matsuura
  • Reiko Koichihara
  • Seizure.2019 Dec;73:75-78. S1059-1311(19)30136-0. doi: 10.1016/j.seizure.2019.10.023.Epub 2019-11-05.

冠動脈疾患治療のための5-リポキシゲナーゼ活性化蛋白質阻害剤の新規化学シリーズの開発

Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease.
  • Malin Lemurell
  • Johan Ulander
  • Hans Emtenäs
  • Susanne Winiwarter
  • Johan Broddefalk
  • Marianne Swanson
  • Martin A Hayes
  • Luna Prieto Garcia
  • Annika Westin Eriksson
  • Johan Meuller
  • Johan Cassel
  • Gabrielle Saarinen
  • Zhong-Qing Yuan
  • Christian Löfberg
  • Staffan Karlsson
  • Monica Sundqvist
  • Carl Whatling
  • J. Med. Chem..2019 05;62(9):4325-4349. doi: 10.1021/acs.jmedchem.8b02012.Epub 2019-04-15.

前立腺閉塞症良性疾患に対するUNBLOCSランダム化比較試験における前立腺の経尿道的切除術対チュリウムレーザー経尿道的気化切除術のCost-Effectiveness

The Cost-Effectiveness of Transurethral resection of the prostate versus Thulium laser transurethral vaporesection of the prostate in the UNBLOCS randomised controlled trial for benign prostatic obstruction.
  • S M Noble
  • A M Ahern
  • J Worthington
  • H Hashim
  • H Taylor
  • G J Young
  • S Brookes
  • P Abrams
  • L Johnson
  • R Khan
  • T Page
  • S Swami
  • J A Lane
  • BJU Int..2020 Jun;doi: 10.1111/bju.15138.Epub 2020-06-17.

HIV感染者におけるcART開始後の治療変更:ドイツClinSurv HIVコホート2005-2017のレトロスペクティブ分析

Treatment modification after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005-2017.
  • Melanie Stecher
  • Philipp Schommers
  • Christian Kollan
  • Matthias Stoll
  • Frieder Kuhlendahl
  • Hans-Jürgen Stellbrink
  • Jan-Christian Wasmuth
  • Christoph Stephan
  • Laura Hamacher
  • Clara Lehmann
  • Christoph Boesecke
  • Johannes Bogner
  • Stefan Esser
  • Carlos Fritzsche
  • Annette Haberl
  • Christian Hoffmann
  • Björn Jensen
  • Carolynne Schwarze-Zander
  • Martin Platten
  • Gerd Fätkenheuer
  • Daniel Schmidt
  • Barbara Gunsenheimer-Bartmeyer
  • Jörg Janne Vehreschild
  • Infection.2020 Jul;10.1007/s15010-020-01469-6. doi: 10.1007/s15010-020-01469-6.Epub 2020-07-01.

Toll-like Receptor 4 (TLR4)の遮断は、高グルコースに曝露されたライディッヒ細胞において酸化ストレスを軽減し、phospho-ERK1/2レベルを回復させます

Blockade of Toll-like receptor 4 (TLR4) reduces oxidative stress and restores phospho-ERK1/2 levels in Leydig cells exposed to high glucose.
  • Tatiana Karpova
  • Amanda Almeida de Oliveira
  • Huda Naas
  • Fernanda Priviero
  • Kenia Pedrosa Nunes
  • Life Sci..2020 Mar;245:117365. S0024-3205(20)30112-0. doi: 10.1016/j.lfs.2020.117365.Epub 2020-01-27.

フェニル-2,4,6-トリメチルベンゾイルホスフィン酸リチウムで光重合したゼラチンメタクリロイル系ハイドロゲルのヒト初代腎近位尿細管上皮細胞における毒性と光増感性の評価

Toxicity and photosensitizing assessment of gelatin methacryloyl-based hydrogels photoinitiated with lithium phenyl-2,4,6-trimethylbenzoylphosphinate in human primary renal proximal tubule epithelial cells.
  • Alexander K Nguyen
  • Peter L Goering
  • Vytas Reipa
  • Roger J Narayan
  • Biointerphases.2019 05;14(2):021007. doi: 10.1116/1.5095886.Epub 2019-05-03.

腫瘍細胞株のプロテオーム活性のランドスケープが薬物反応を決定する

Proteome activity landscapes of tumor cell lines determine drug responses.
  • Martin Frejno
  • Chen Meng
  • Benjamin Ruprecht
  • Thomas Oellerich
  • Sebastian Scheich
  • Karin Kleigrewe
  • Enken Drecoll
  • Patroklos Samaras
  • Alexander Hogrebe
  • Dominic Helm
  • Julia Mergner
  • Jana Zecha
  • Stephanie Heinzlmeir
  • Mathias Wilhelm
  • Julia Dorn
  • Hans-Michael Kvasnicka
  • Hubert Serve
  • Wilko Weichert
  • Bernhard Kuster
  • Nat Commun.2020 Jul;11(1):3639. 10.1038/s41467-020-17336-9. doi: 10.1038/s41467-020-17336-9.Epub 2020-07-20.

プロテオームとタンパク質のリン酸化の変化は、ポプラ植物のカドミウム毒性を緩和するための外因性窒素の保護的役割を明らかにした

Changes in Proteome and Protein Phosphorylation Reveal the Protective Roles of Exogenous Nitrogen in Alleviating Cadmium Toxicity in Poplar Plants.
  • Jinliang Huang
  • Xiaolu Wu
  • Feifei Tian
  • Qi Chen
  • Pengrui Luo
  • Fan Zhang
  • Xueqin Wan
  • Yu Zhong
  • Qinglin Liu
  • Tiantian Lin
  • Int J Mol Sci.2019 Dec;21(1). E278. doi: 10.3390/ijms21010278.Epub 2019-12-31.

アフリカにおける COVID-19 パンデミック時の定期的な小児予防接種:SARS-CoV-2 感染の過剰リスクと健康上の利益の便益リスク分析

Routine childhood immunisation during the COVID-19 pandemic in Africa: a benefit-risk analysis of health benefits versus excess risk of SARS-CoV-2 infection.
  • Kaja Abbas
  • Simon R Procter
  • Kevin van Zandvoort
  • Andrew Clark
  • Sebastian Funk
  • Tewodaj Mengistu
  • Dan Hogan
  • Emily Dansereau
  • Mark Jit
  • Stefan Flasche
  • Lancet Glob Health.2020 Jul;S2214-109X(20)30308-9. doi: 10.1016/S2214-109X(20)30308-9.Epub 2020-07-17.

ポリ(2-ヒドロキシエチルメタクリレート)をベースとした複合非晶質固体分散体。親水性不溶性高分子担体からの薬物放出に関する研究(多孔質化剤の存在下および非存在下での研究

Complex amorphous solid dispersions based on poly(2-hydroxyethyl methacrylate): Study of drug release from a hydrophilic insoluble polymeric carrier in the presence and absence of a porosity increasing agent.
  • Melissa Everaerts
  • Guy Van den Mooter
  • Int J Pharm.2019 Jul;566:77-88. S0378-5173(19)30399-0. doi: 10.1016/j.ijpharm.2019.05.040.Epub 2019-05-16.

孵化したばかりの日本のメダカにおける転写応答は、希釈アスファルト曝露後の発生奇形と関連している

Transcriptional responses in newly-hatched Japanese medaka (Oryzias latipes) associated with developmental malformations following diluted bitumen exposure.
  • Barry N Madison
  • Sarah J Wallace
  • Jing Zhang
  • Peter V Hodson
  • Valerie S Langlois
  • Comp. Biochem. Physiol. Part D Genomics Proteomics.2020 May;35:100685. S1744-117X(20)30032-0. doi: 10.1016/j.cbd.2020.100685.Epub 2020-05-06.

新しい近赤外ハイパースペクトルイメージング(NIR-HSI)法を用いて、水生サンプル中の微小なマイクロプラスチックを迅速かつ直接検出する

Rapid and direct detection of small microplastics in aquatic samples by a new near infrared hyperspectral imaging (NIR-HSI) method.
  • Stefania Piarulli
  • Giorgia Sciutto
  • Paolo Oliveri
  • Cristina Malegori
  • Silvia Prati
  • Rocco Mazzeo
  • Laura Airoldi
  • Chemosphere.2020 Jul;260:127655. S0045-6535(20)31850-6. doi: 10.1016/j.chemosphere.2020.127655.Epub 2020-07-10.

顎関節症を伴う若年性特発性関節炎における疼痛および開口部に対する関節内コルチコステロイド注射の効果。システマティックレビューとメタアナリシス

Effect of intra-articular corticosteroid injections on pain and mouth opening in juvenile idiopathic arthritis with temporomandibular involvement: A systematic review and meta-analysis.
  • Gregory S Antonarakis
  • Adrien Blanc
  • Delphine S Courvoisier
  • Paolo Scolozzi
  • J Craniomaxillofac Surg.2020 Jun;S1010-5182(20)30155-4. doi: 10.1016/j.jcms.2020.06.010.Epub 2020-06-27.

低磁場磁気共鳴イメージングを用いた流体減衰反転回復シーケンス上の酸素誘発性イヌ脳脊髄液の高輝度化の低減のための適切な霊感酸素の割合

Proper fraction of inspired oxygen for reduction of oxygen-induced canine cerebrospinal fluid hyperintensity on fluid attenuation inversion recovery sequence using low-field magnetic resonance imaging.
  • Moonjung Jang
  • Jaewoo Hwang
  • Jihye Nam
  • Dalhae Kim
  • Wongyun Son
  • Inhyung Lee
  • Mincheol Choi
  • Junghee Yoon
  • J. Vet. Med. Sci..2020 Jul;doi: 10.1292/jvms.20-0060.Epub 2020-07-20.

消化管の神経内分泌がんと神経内分泌非神経内分泌混合新生物は予後が同じ?12,878例のデータベース解析

Do neuroendocrine carcinomas and mixed neuroendocrine-non-neuroendocrine neoplasm of the gastrointestinal tract have the same prognosis? A database analysis of 12,878 cases.
  • Huiying Shi
  • Cuihua Qi
  • Lingjun Meng
  • Hailing Yao
  • Chen Jiang
  • Mengke Fan
  • Suya Pang
  • Qin Zhang
  • Rong Lin
  • Ther Adv Endocrinol Metab.2020;11:2042018820938304. 10.1177_2042018820938304. doi: 10.1177/2042018820938304.Epub 2020-07-06.

ヒト免疫不全ウイルスの母子感染予防のための非ヌクレオシド系逆転写抑制剤-高活性抗レトロウイルス療法の効果には治療経験と妊娠の繰り返しが影響する

Treatment Experience and Repeat Pregnancy Impact the Effectiveness of Non-Nucleoside Reverse Transcription Inhibitor-Highly Active Antiretroviral Therapy for the Prevention of Mother to Child Transmission of Human Immunodeficiency Virus.
  • Indira B Martin
  • Stanley Read
  • Richard Harrigan
  • M Perry Gomez
  • AIDS Res. Hum. Retroviruses.2020 Jun;doi: 10.1089/AID.2019.0001.Epub 2020-06-09.

北極・南極海堆積物中のポリ塩化ジベンゾ-p-ダイオキシン類とジベンゾフラン類の前駆体。気候変動に直面した環境問題

Precursors of polychlorinated dibenzo-p-dioxins and dibenzofurans in Arctic and Antarctic marine sediments: Environmental concern in the face of climate change.
  • Marta Ewelina Kobusińska
  • Krzysztof Konrad Lewandowski
  • Anna Panasiuk
  • Leszek Łęczyński
  • Magdalena Urbaniak
  • Tadeusz Ossowski
  • Elżbieta Niemirycz
  • Chemosphere.2020 Jul;260:127605. S0045-6535(20)31800-2. doi: 10.1016/j.chemosphere.2020.127605.Epub 2020-07-10.

酵母を用いたスクリーニングにより、ニーマンピック病タイプCで影響を受ける細胞経路が明らかになった

Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C.
  • Alexandria Colaco
  • María E Fernández-Suárez
  • Dawn Shepherd
  • Lihi Gal
  • Chen Bibi
  • Silvia Chuartzman
  • Alan Diot
  • Karl Morten
  • Emily Eden
  • Forbes D Porter
  • Joanna Poulton
  • Nick Platt
  • Maya Schuldiner
  • Frances M Platt
  • Life Sci Alliance.2020 Jul;3(7). e201800253. doi: 10.26508/lsa.201800253.Epub 2020-06-02.

全ゲノムシークエンシングにより解決された進行性偽リウマチ性異形成:WISP3の新規変異と文献のレビュー

Progressive Pseudorheumatoid Dysplasia resolved by whole exome sequencing: a novel mutation in WISP3 and review of the literature.
  • Ben Pode-Shakked
  • Asaf Vivante
  • Ortal Barel
  • Shai Padeh
  • Dina Marek-Yagel
  • Alvit Veber
  • Shachar Abudi
  • Aviva Eliyahu
  • Irit Tirosh
  • Shiri Shpilman
  • Shirlee Shril
  • Friedhelm Hildebrandt
  • Mordechai Shohat
  • Yair Anikster
  • BMC Med. Genet..2019 03;20(1):53. 10.1186/s12881-019-0787-x. doi: 10.1186/s12881-019-0787-x.Epub 2019-03-29.

Intrigue.イマチニブ後の進行性消化管間質腫瘍を対象としたリプレチニブ対スニチニブの第III相試験

Intrigue: Phase III study of ripretinib versus sunitinib in advanced gastrointestinal stromal tumor after imatinib.
  • John Nemunaitis
  • Sebastian Bauer
  • Jean-Yves Blay
  • Khalil Choucair
  • Hans Gelderblom
  • Suzanne George
  • Patrick Schöffski
  • Margaret von Mehren
  • John Zalcberg
  • Haroun Achour
  • Rodrigo Ruiz-Soto
  • Michael C Heinrich
  • Future Oncol.2020 Jan;16(1):4251-4264. doi: 10.2217/fon-2019-0633.Epub 2019-11-22.

ターンオーバー、ミネラル化、体積分類の潜在的バイオマーカー。血液透析患者におけるNMRメタボロミクスを用いた結果.

Potential Biomarkers of the Turnover, Mineralization, and Volume Classification: Results Using NMR Metabolomics in Hemodialysis Patients.
  • Aline L Baptista
  • Kallyandra Padilha
  • Pamella A Malagrino
  • Gabriela Venturini
  • Ana Cm Zeri
  • Luciene M Dos Reis
  • Janaina S Martins
  • Vanda Jorgetti
  • Alexandre C Pereira
  • Silvia M Titan
  • Rosa Ma Moyses
  • JBMR Plus.2020 Jul;4(7):e10372. JBM410372. doi: 10.1002/jbm4.10372.Epub 2020-05-27.

重複する臨床病理学的特徴を有する赤色染料による遅延性タトゥー反応。高周波超音波および線間光干渉断層撮影による検査

Delayed Tattoo Reaction From Red Dye With Overlapping Clinicopathological Features: Examination With High-Frequency Ultrasound and Line-Field Optical Coherence Tomography.
  • Linda Tognetti
  • Sean Ekinde
  • Cyril Habougit
  • Elisa Cinotti
  • Pietro Rubegni
  • Jean Luc Perrot
  • Dermatol Pract Concept.2020 Jul;10(3):e2020053. dp1003a53. doi: 10.5826/dpc.1003a53.Epub 2020-06-29.

健康活動プログラムの効果の持続性と費用対効果:プライマリケアでのカウンセラーによるうつ病の短期心理治療:無作為化比較試験の12ヶ月間の追跡調査

Sustained effectiveness and cost-effectiveness of the Healthy Activity Programme, a brief psychological treatment for depression delivered by lay counsellors in primary care: 12-month follow-up of a randomised controlled trial.
  • Benedict Weobong
  • Helen A Weiss
  • David McDaid
  • Daisy R Singla
  • Steven D Hollon
  • Abhijit Nadkarni
  • A-La Park
  • Bhargav Bhat
  • Basavraj Katti
  • Arpita Anand
  • Sona Dimidjian
  • Ricardo Araya
  • Michael King
  • Lakshmi Vijayakumar
  • G Terence Wilson
  • Richard Velleman
  • Betty R Kirkwood
  • Christopher G Fairburn
  • Vikram Patel
  • PLoS Med..2017 Sep;14(9):e1002385. PMEDICINE-D-17-01349. doi: 10.1371/journal.pmed.1002385.Epub 2017-09-12.

ニンジン(Daucus carota)における2つのζ-カロテンデサチュラーゼパラログの役割の違い。ZDS1 は、植物の発生とカロテノイド合成に不可欠な機能性遺伝子です

Differential role of the two ζ-carotene desaturase paralogs in carrot (Daucus carota): ZDS1 is a functional gene essential for plant development and carotenoid synthesis.
  • Carlos Flores-Ortiz
  • Lilia M Alvarez
  • Alejandro Undurraga
  • Daniela Arias
  • Felipe Durán
  • Guillermo Wegener
  • Claudia Stange
  • Plant Sci..2020 Feb;291:110327. S0168-9452(19)31500-6. doi: 10.1016/j.plantsci.2019.110327.Epub 2019-11-26.

角膜内皮再生のための生分解性および生体適合性のあるポリエチレングリコールベースのハイドロゲルフィルム

Biodegradable and biocompatible poly(ethylene glycol)-based hydrogel films for the regeneration of corneal endothelium.
  • Berkay Ozcelik
  • Karl D Brown
  • Anton Blencowe
  • Katharina Ladewig
  • Geoffrey W Stevens
  • Jean-Pierre Y Scheerlinck
  • Keren Abberton
  • Mark Daniell
  • Greg G Qiao
  • Adv Healthc Mater.2014 Sep;3(9):1496-507. doi: 10.1002/adhm.201400045.Epub 2014-03-20.

アルジェリアの中央草原Djelfaにおける子羊におけるジアルジア・デュオデナリスの発生と分子特性

Occurrence and molecular characterization of Giardia duodenalis in lambs in Djelfa, the central steppe of Algeria.
  • Soumaya Benhassine
  • Djamel Baroudi
  • Ahcene Hakem
  • Myriam Thomas
  • AbdElkarim Laatamna
  • Salem Belkessa
  • Yaoyu Feng
  • Dawn Roellig
  • Xiaohua Chen
  • Karim Tarik Adjou
  • Lihua Xiao
  • Parasitol. Res..2020 Jul;10.1007/s00436-020-06808-y. doi: 10.1007/s00436-020-06808-y.Epub 2020-07-14.

無精子症ドナーからの精液血漿中のプロタミンの定量を調査した研究。閉塞性無精子症の診断、精巣精子採取(TESE)や人工授精精子注入(ICSI)のための出産精子の採取に向けた新たな方法の提案

The study investigating the determination of protamine in seminal plasma from azoospermic donors: Suggestion of new methods to diagnose obstructive azoospermia, and to capture childbearing sperm for testicular sperm extraction (TESE) and insemination sperm injection (ICSI).
  • Masatoki Katayama
  • Satoru Kaneko
  • Takahiro Tsukimura
  • Kiyoshi Takamatsu
  • Tadayasu Togawa
  • Anal. Biochem..2020 Jul;604:113792. S0003-2697(20)30324-9. doi: 10.1016/j.ab.2020.113792.Epub 2020-07-02.

Tie2の活性化は、ヒトのセプシスにおける内皮グリコカリックスの保護と再構成を促進する

Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis.
  • Carolin Christina Drost
  • Alexandros Rovas
  • Kristina Kusche-Vihrog
  • Paul Van Slyke
  • Harold Kim
  • Van C Hoang
  • Jason T Maynes
  • Dirk Oliver Wennmann
  • Hermann Pavenstädt
  • Wolfgang Linke
  • Alexander Lukasz
  • Bettina Hesse
  • Philipp Kümpers
  • Thromb. Haemost..2019 Nov;119(11):1827-1838. doi: 10.1055/s-0039-1695768.Epub 2019-09-07.

前立腺閉塞の二次的な下部尿路症状に対する前立腺のバイポーラ対モノポーラ経尿道的切除。コクランレビュー

Bipolar vs. monopolar transurethral resection of the prostate for lower urinary tract symptoms secondary to benign prostatic obstruction: A Cochrane review.
  • Cameron Edwin Alexander
  • Malo M F Scullion
  • Muhammad Imran Omar
  • Yuhong Yuan
  • Charalampos Mamoulakis
  • James M O N'Dow
  • Changhao Chen
  • Thomas B L Lam
  • Can Urol Assoc J.2020 Jun;cuaj.6464. doi: 10.5489/cuaj.6464.Epub 2020-06-16.

3D-QSAR、分子ドッキング、分子動力学シミュレーションを用いて、新規な(5-イミダゾール-2-イル-4-フェニルピリミジン-2-イル)2-(2-ピリジルアミノ)エチルアミン誘導体のグリコーゲン合成キナーゼ3阻害剤としてのインシリコデザインを行った

In silico design novel (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine derivatives as inhibitors for glycogen synthase kinase 3 based on 3D-QSAR, molecular docking and molecular dynamics simulation.
  • Qingxiu He
  • Chu Han
  • Guangping Li
  • Haiqiong Guo
  • Yuxuan Wang
  • Yong Hu
  • Zhihua Lin
  • Yuanqiang Wang
  • Comput Biol Chem.2020 Jul;88:107328. S1476-9271(20)30643-5. doi: 10.1016/j.compbiolchem.2020.107328.Epub 2020-07-04.

UAE1 阻害は膵臓癌におけるアンフォールドタンパク応答、DNA 損傷、カスパーゼ依存性細胞死を媒介する

UAE1 inhibition mediates the unfolded protein response, DNA damage and caspase-dependent cell death in pancreatic cancer.
  • Yajing Liu
  • Sahezeel Awadia
  • Amy Delaney
  • Merna Sitto
  • Carl Engelke
  • Heli Patel
  • Andrew Calcaterra
  • Sylvia Zelenka-Wang
  • Hojin Lee
  • Joseph Contessa
  • Nouri Neamati
  • Mats Ljungman
  • Theodore S Lawrence
  • Meredith A Morgan
  • Alnawaz Rehemtulla
  • Transl Oncol.2020 Jul;13(11):100834. S1936-5233(20)30326-0. doi: 10.1016/j.tranon.2020.100834.Epub 2020-07-17.

放射線科での偶発的なCOVID-19。乳がんのCT病期分類を受けた無症候性患者におけるCOVID-19の放射線所見

Incidental COVID-19 in the radiology department: Radiographic findings of COVID-19 in asymptomatic patient undergoing CT staging for breast cancer.
  • Kevin Yoo
  • Robert Y Choi
  • Justin Sun
  • Clinton Veselis
  • Bhishak Kamat
  • Maruti Kumaran
  • Omar Agosto
  • Hillel S Maresky
  • Radiol Case Rep.2020 Sep;15(9):1614-1617. S1930-0433(20)30274-0. doi: 10.1016/j.radcr.2020.05.080.Epub 2020-06-11.

健康なボランティアを対象としたAZD5718の第1相薬物動態試験。ロスバスタチンとの併用投与、製剤および食品の経口バイオアベイラビリティーへの影響

Phase 1 Pharmacokinetic Study of AZD5718 in Healthy Volunteers: Effects of Coadministration With Rosuvastatin, Formulation and Food on Oral Bioavailability.
  • Hans Ericsson
  • Karin Nelander
  • Maria Heijer
  • Magnus Kjaer
  • Eva-Lotte Lindstedt
  • Muna Albayaty
  • Pablo Forte
  • Maria Lagerström-Fermér
  • Stanko Skrtic
  • Clin Pharmacol Drug Dev.2020 Apr;9(3):411-421. doi: 10.1002/cpdd.756.Epub 2019-12-02.

同じ一次切除標本によく分化した甲状腺がんと退形成性甲状腺がんが共存していること:13例の連続したシリーズにおける2つの成分の免疫フェノタイプおよび遺伝学的比較、および文献のレビュー

Coexisting well-differentiated and anaplastic thyroid carcinoma in the same primary resection specimen: immunophenotypic and genetic comparison of the two components in a consecutive series of 13 cases and a review of the literature.
  • Moira Ragazzi
  • Federica Torricelli
  • Benedetta Donati
  • Alessia Ciarrocchi
  • Dario de Biase
  • Giovanni Tallini
  • Eleonora Zanetti
  • Alessandra Bisagni
  • Elisabetta Kuhn
  • Davide Giordano
  • Andrea Frasoldati
  • Simonetta Piana
  • Virchows Arch..2020 Jul;10.1007/s00428-020-02891-9. doi: 10.1007/s00428-020-02891-9.Epub 2020-07-18.

東南アジアにおけるマラリア予防のためのナフトキン-アジスロマイシン共剤の有効性と安全性。第 3 相、二重盲検、無作為化、プラセボ対照試験

Efficacy and Safety of a Naphthoquine-Azithromycin Co-Formulation for Malaria Prophylaxis in Southeast Asia: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial.
  • Henglin Yang
  • Jingyan Wang
  • Hui Liu
  • Yan Zhao
  • Seetha Lakshmi
  • Xingliang Li
  • Renhua Nie
  • Chunfu Li
  • Hengye Wang
  • Yaming Cao
  • Lynette Menezes
  • Liwang Cui
  • Clin. Infect. Dis..2020 Jul;ciaa1018. doi: 10.1093/cid/ciaa1018.Epub 2020-07-20.

職人的・小規模な金採掘(ASGM)活動の影響を受けた土壌における銅、鉛、亜鉛、ヒ素の固相分離と放出保持メカニズム

Solid-phase partitioning and release-retention mechanisms of copper, lead, zinc and arsenic in soils impacted by artisanal and small-scale gold mining (ASGM) activities.
  • Carlito Baltazar Tabelin
  • Marthias Silwamba
  • Florifern C Paglinawan
  • Alissa Jane S Mondejar
  • Ho Gia Duc
  • Vannie Joy Resabal
  • Einstine M Opiso
  • Toshifumi Igarashi
  • Shingo Tomiyama
  • Mayumi Ito
  • Naoki Hiroyoshi
  • Mylah Villacorte-Tabelin
  • Chemosphere.2020 Jul;260:127574. S0045-6535(20)31769-0. doi: 10.1016/j.chemosphere.2020.127574.Epub 2020-07-10.

ミグラスタットによる治療を受けた成人ニーマン・ピック病C型患者における嚥下障害と嚥下機能の縦断的変化の特徴付け

Characterization of Dysphagia and Longitudinal Changes in Swallowing Function in Adults with Niemann-Pick Disease Type C Treated with Miglustat.
  • Courtney Lewis
  • Megan Keage
  • Miyuki Watanabe
  • Danielle Schubiger
  • Dennis Velakoulis
  • Mark Walterfang
  • Adam P Vogel
  • Dysphagia.2020 Jun;10.1007/s00455-020-10145-8. doi: 10.1007/s00455-020-10145-8.Epub 2020-06-19.