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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

HCT-15誘発大腸直腸腫瘍異種移植片におけるEGFR陽性腫瘍診断のためのインジウムキレートセツキシマブのSPECTイメージング評価

SPECT imaging evaluation of indium-chelated cetuximab for diagnosing EGFR-positive tumor in an HCT-15-induced colorectal xenograft.
  • Bin-Bin Shih
  • Yi-Fang Chang
  • Chun-Chia Cheng
  • Hao-Jhih Yang
  • Kang-Wei Chang
  • Ai-Sheng Ho
  • Hua-Ching Lin
  • Chun Yeh
  • Chun-Chao Chang
  • J Chin Med Assoc.2017 Dec;80(12):766-773. S1726-4901(17)30232-0. doi: 10.1016/j.jcma.2017.02.010.Epub 2017-09-29.

CINRGベッカー自然史研究。ベースラインの特徴

The CINRG Becker Natural History Study: Baseline Characteristics.
  • Paula R Clemens
  • Gabriela Niizawa
  • Jia Feng
  • Julaine Florence
  • Andrea Smith D'Alessandro
  • Lauren P Morgenroth
  • Ksenija Gorni
  • Michela Guglieri
  • Anne Connolly
  • Matthew Wicklund
  • Tulio Bertorini
  • Jean K Mah
  • Mathula Thangarajh
  • Edward Smith
  • Nancy Kuntz
  • Craig M McDonald
  • Erik K Henricson
  • Saila Upadhyayula
  • Barry Byrne
  • Georgios Manousakis
  • Amy Harper
  • Elena Bravver
  • Susan Iannaccone
  • Christopher Spurney
  • Avital Cnaan
  • Heather Gordish-Dressman
  • Muscle Nerve.2020 Jun;doi: 10.1002/mus.27011.Epub 2020-06-21.

4カ国の健康な2歳未満の乳幼児および小児の呼吸数および酸素飽和度基準値に及ぼす高高度の影響:横断的研究

Effects of high altitude on respiratory rate and oxygen saturation reference values in healthy infants and children younger than 2 years in four countries: a cross-sectional study.
  • Mary E Crocker
  • Shakir Hossen
  • Dina Goodman
  • Suzanne M Simkovich
  • Miles Kirby
  • Lisa M Thompson
  • Ghislaine Rosa
  • Sarada S Garg
  • Gurusamy Thangavel
  • Eric D McCollum
  • Jennifer Peel
  • Thomas Clasen
  • William Checkley
  • Lancet Glob Health.2020 03;8(3):e362-e373. S2214-109X(19)30543-1. doi: 10.1016/S2214-109X(19)30543-1.

電池型ハイブリッドスーパーキャパシタの高エネルギー密度化に向けたNiMoO@金属被覆グラフェン・インクナノシート構造の合成を容易に行った

A facile synthesis of a NiMoO@metal-coated graphene-ink nanosheet structure towards the high energy density of a battery type-hybrid supercapacitor.
  • Venkata Thulasivarma Chebrolu
  • Balamuralitharan Balakrishnan
  • Selvaraj Aravindha Raja
  • Hee-Je Kim
  • Dalton Trans.2020 Jul;49(28):9762-9772. doi: 10.1039/d0dt00624f.

骨癌性疼痛ラットにおけるモルヒネ寛容性に対する骨近鍼と電気鍼を組み合わせた早期介入と後根神経節におけるHDACとMORの発現に及ぼす影響

[Early intervention of bone-nearby acupuncture combined with electroacupuncture on morphine tolerance in bone cancer pain rats and its effect on the expression of HDAC and MOR in dorsal root ganglia].
  • Xue-Mei Zhong
  • Jun-Fan Fang
  • Bin Jiang
  • Jie Zhou
  • Yang-Qian Cai
  • Yi Liang
  • Jian-Qiao Fang
  • Feng Chen
  • Jun-Ying Du
  • Zhongguo Zhen Jiu.2020 Apr;40(4):405-10. doi: 10.13703/j.0255-2930.20190822-k0002.

プロアポトーシスBcl-2関連タンパク質BidとBakによるスーパーオキシド誘発細胞死の実行

Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.
  • Muniswamy Madesh
  • Wei-Xing Zong
  • Brian J Hawkins
  • Subbiah Ramasamy
  • Thilagavathi Venkatachalam
  • Partha Mukhopadhyay
  • Patrick J Doonan
  • Krishna M Irrinki
  • Mohanraj Rajesh
  • Pál Pacher
  • Craig B Thompson
  • Mol. Cell. Biol..2009 Jun;29(11):3099-112. MCB.01845-08. doi: 10.1128/MCB.01845-08.Epub 2009-03-30.

-由来のPSMαペプチドは好中球のFPR2を活性化するが、β-アレスチンのリクルートと走化性を媒介する能力を欠いている

-Derived PSMα Peptides Activate Neutrophil FPR2 but Lack the Ability to Mediate β-Arrestin Recruitment and Chemotaxis.
  • Martina Sundqvist
  • Karin Christenson
  • Michael Gabl
  • André Holdfeldt
  • Karin Jennbacken
  • Thor C Møller
  • Claes Dahlgren
  • Huamei Forsman
  • J. Immunol..2019 12;203(12):3349-3360. jimmunol.1900871. doi: 10.4049/jimmunol.1900871.Epub 2019-11-06.

2030年に向けた戦略的展望:日本のアレルギー・免疫学研究-二次出版

Strategic Outlook toward 2030: Japan's research for allergy and immunology - Secondary publication.
  • Takeya Adachi
  • Keigo Kainuma
  • Koichiro Asano
  • Masayuki Amagai
  • Hiroyuki Arai
  • Ken J Ishii
  • Komei Ito
  • Eiichi Uchio
  • Motohiro Ebisawa
  • Mitsuhiro Okano
  • Kenji Kabashima
  • Kenji Kondo
  • Satoshi Konno
  • Hidehisa Saeki
  • Mariko Sonobe
  • Mizuho Nagao
  • Nobuyuki Hizawa
  • Atsuki Fukushima
  • Shigeharu Fujieda
  • Kenji Matsumoto
  • Hideaki Morita
  • Kazuhiko Yamamoto
  • Akemi Yoshimoto
  • Mayumi Tamari
  • Allergol Int.2020 Jun;S1323-8930(20)30056-3. doi: 10.1016/j.alit.2020.04.006.Epub 2020-06-26.

X-Linked Adrenoleukodystrophyにおける脳脱髄の根底にある表現型修飾因子を同定するためのマルチオーミックアプローチ

Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy.
  • Phillip A Richmond
  • Frans van der Kloet
  • Frederic M Vaz
  • David Lin
  • Anuli Uzozie
  • Emma Graham
  • Michael Kobor
  • Sara Mostafavi
  • Perry D Moerland
  • Philipp F Lange
  • Antoine H C van Kampen
  • Wyeth W Wasserman
  • Marc Engelen
  • Stephan Kemp
  • Clara D M van Karnebeek
  • Front Cell Dev Biol.2020;8:520. doi: 10.3389/fcell.2020.00520.Epub 2020-06-25.

COL6関連ジストロフィーとデュシェンヌ筋ジストロフィーの中間型とベスレムミオパシー型における下肢筋の関与。断面研究

Lower Extremity Muscle Involvement in the Intermediate and Bethlem Myopathy Forms of COL6-Related Dystrophy and Duchenne Muscular Dystrophy: A Cross-Sectional Study.
  • Abhinandan Batra
  • Donovan J Lott
  • Rebecca Willcocks
  • Sean C Forbes
  • William Triplett
  • Jahannaz Dastgir
  • Pomi Yun
  • A Reghan Foley
  • Carsten G Bönnemann
  • Krista Vandenborne
  • Glenn A Walter
  • J Neuromuscul Dis.2020 Jun;JND190457. doi: 10.3233/JND-190457.Epub 2020-06-06.

テオフィリンとデキサメタゾンの併用は、炎症を抑制し、タバコの煙の抽出物に暴露された単球に見られるHDAC2発現の低下を防ぐ

Theophylline and dexamethasone in combination reduce inflammation and prevent the decrease in HDAC2 expression seen in monocytes exposed to cigarette smoke extract.
  • Xue-Jiao Sun
  • Zhan-Hua Li
  • Yang Zhang
  • Xiao-Ning Zhong
  • Zhi-Yi He
  • Ji-Hong Zhou
  • Si-Ning Chen
  • Yuan Feng
  • Exp Ther Med.2020 May;19(5):3425-3431. ETM-0-0-8584. doi: 10.3892/etm.2020.8584.Epub 2020-03-06.

フォルミルペプチド受容体2-G複合体の構造がリガンド認識とシグナル伝達の謎を解き明かす

Structure of formylpeptide receptor 2-G complex reveals insights into ligand recognition and signaling.
  • Youwen Zhuang
  • Heng Liu
  • X Edward Zhou
  • Ravi Kumar Verma
  • Parker W de Waal
  • Wonjo Jang
  • Ting-Hai Xu
  • Lei Wang
  • Xing Meng
  • Gongpu Zhao
  • Yanyong Kang
  • Karsten Melcher
  • Hao Fan
  • Nevin A Lambert
  • H Eric Xu
  • Cheng Zhang
  • Nat Commun.2020 02;11(1):885. 10.1038/s41467-020-14728-9. doi: 10.1038/s41467-020-14728-9.Epub 2020-02-14.

メープルシロップ尿症Ib型患者由来の誘導多能性幹細胞株(SDQLCHi006-A)は、BCKDHB遺伝子のp.R168Cおよびp.T322Iの複合ヘテロ変異を有する

An induced pluripotent stem cell line (SDQLCHi006-A) derived from a patient with maple syrup urine disease type Ib carrying compound heterozygous mutations of p.R168C and p.T322I in BCKDHB gene.
  • Yue Li
  • Haiyan Zhang
  • Beibei Yan
  • Yanyan Ma
  • Xiaomeng Yang
  • Jingyun Guan
  • Yuqiang Lv
  • Min Gao
  • Jian Ma
  • Zhongtao Gai
  • Yi Liu
  • Stem Cell Res.2019 10;40:101579. S1873-5061(19)30209-0. doi: 10.1016/j.scr.2019.101579.Epub 2019-09-14.

リジン特異的デメチラーゼ1(LSD1)を薬理学的に阻害することで,Schistosoma mansoniの生存能力を損なう全世界的な転写調節障害と超微細構造変化が誘導される.

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni.
  • Vitor Coutinho Carneiro
  • Isabel Caetano de Abreu da Silva
  • Murilo Sena Amaral
  • Adriana S A Pereira
  • Gilbert Oliveira Silveira
  • David da Silva Pires
  • Sergio Verjovski-Almeida
  • Frank J Dekker
  • Dante Rotili
  • Antonello Mai
  • Eduardo José Lopes-Torres
  • Dina Robaa
  • Wolfgang Sippl
  • Raymond J Pierce
  • M Teresa Borrello
  • A Ganesan
  • Julien Lancelot
  • Silvana Thiengo
  • Monica Ammon Fernandez
  • Amanda Roberta Revoredo Vicentino
  • Marina Moraes Mourão
  • Fernanda Sales Coelho
  • Marcelo Rosado Fantappié
  • PLoS Negl Trop Dis.2020 Jul;14(7):e0008332. PNTD-D-19-01913. doi: 10.1371/journal.pntd.0008332.Epub 2020-07-01.

過酢酸-エタノールベースの除菌剤または高度酸化プロセスを用いたドライフルーツ、ピスタチオナッツ、コーンフレークおよびチョコレートクラム上のサルモネラ菌およびリステリア・モノサイトゲネスの不活化

Inactivation of Salmonella and Listeria monocytogenes on dried fruit, pistachio nuts, cornflakes and chocolate crumb using a peracetic acid-ethanol based sanitizer or Advanced Oxidation Process.
  • Mahdiyeh Hasani
  • Fan Wu
  • Kayla Hu
  • Jeffery Farber
  • Keith Warriner
  • Int. J. Food Microbiol..2020 Jul;333:108789. S0168-1605(20)30283-X. doi: 10.1016/j.ijfoodmicro.2020.108789.Epub 2020-07-15.

太りすぎと肥満の成人の血漿リピドーム上のカルノシンサプリメントの効果:パイロット無作為化比較試験

Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial.
  • Estifanos Baye
  • Jozef Ukropec
  • Maximilian Pj de Courten
  • Silvia Vallova
  • Patrik Krumpolec
  • Timea Kurdiova
  • Giancarlo Aldini
  • Barbara Ukropcova
  • Barbora de Courten
  • Sci Rep.2017 12;7(1):17458. 10.1038/s41598-017-17577-7. doi: 10.1038/s41598-017-17577-7.Epub 2017-12-12.

デクスメデトミジンは神経炎症を調節し、ラット脊髄損傷後にα2-アドレナリン受容体シグナルを介して転帰を改善する

Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury.
  • Jiandong Gao
  • Zhihua Sun
  • Zhaoyang Xiao
  • Qihang Du
  • Xinhuan Niu
  • Gongming Wang
  • Yu-Wen Chang
  • Yongtao Sun
  • Wei Sun
  • Amity Lin
  • Jacqueline C Bresnahan
  • Mervyn Maze
  • Michael S Beattie
  • Jonathan Z Pan
  • Br J Anaesth.2019 12;123(6):827-838. S0007-0912(19)30674-9. doi: 10.1016/j.bja.2019.08.026.Epub 2019-10-14.

また,Schistosoma haematobiumの感染は,過体重・肥満者において血清コレステロール値の低下と脂質プロファイルの改善と関連していることが示唆された.

Schistosoma haematobium infection is associated with lower serum cholesterol levels and improved lipid profile in overweight/obese individuals.
  • Jeannot F Zinsou
  • Jacqueline J Janse
  • Yabo Y Honpkehedji
  • Jean Claude Dejon-Agobé
  • Noemí García-Tardón
  • Pytsje T Hoekstra
  • Marguerite Massinga-Loembe
  • Paul L A M Corstjens
  • Govert J van Dam
  • Martin Giera
  • Peter G Kremsner
  • Maria Yazdanbakhsh
  • Ayola A Adegnika
  • Bruno Guigas
  • PLoS Negl Trop Dis.2020 Jul;14(7):e0008464. PNTD-D-20-00359. doi: 10.1371/journal.pntd.0008464.Epub 2020-07-02.

親水性とラジカルフリーの4-META/MMA-TBBを中心とした新しい骨形成挙動:オッセオインテグレーション骨セメントの意味合い

Novel Osteogenic Behaviors around Hydrophilic and Radical-Free 4-META/MMA-TBB: Implications of an Osseointegrating Bone Cement.
  • Yoshihiko Sugita
  • Takahisa Okubo
  • Makiko Saita
  • Manabu Ishijima
  • Yasuyoshi Torii
  • Miyuki Tanaka
  • Chika Iwasaki
  • Takeo Sekiya
  • Masako Tabuchi
  • Naser Mohammadzadeh Rezaei
  • Takashi Taniyama
  • Nobuaki Sato
  • Juri Saruta
  • Masakazu Hasegawa
  • Makoto Hirota
  • Wonhee Park
  • Masaichi Chang-Il Lee
  • Hatsuhiko Maeda
  • Takahiro Ogawa
  • Int J Mol Sci.2020 Mar;21(7). E2405. doi: 10.3390/ijms21072405.Epub 2020-03-31.

バクテリア由来トポイソメラーゼ阻害剤のスクリーニングによるヒトDNAトポイソメラーゼIIαの新規ATP競合阻害剤の発見

Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors.
  • Žiga Skok
  • Martina Durcik
  • Darja Gramec Skledar
  • Michaela Barančoková
  • Lucija Peterlin Mašič
  • Tihomir Tomašič
  • Anamarija Zega
  • Danijel Kikelj
  • Nace Zidar
  • Janez Ilaš
  • Bioorg. Chem..2020 Jun;102:104049. S0045-2068(20)31346-8. doi: 10.1016/j.bioorg.2020.104049.Epub 2020-06-29.

原発性腫瘍が検出されなかった症例におけるEpstein-Barrウイルス(Herpesviridae, Lymphocryptovirus, HHV-4)の血清学的および分子マーカーを用いた上咽頭癌の診断

[Diagnostics of nasopharyngeal carcinoma with Epstein-Barr virus (Herpesviridae, Lymphocryptovirus, HHV-4) serological and molecular markers in cases of undetected primary tumor location.]
  • N B Senyuta
  • K V Smirnova
  • V N Kondratova
  • A V Ignatova
  • A M Mudunov
  • T E Dushenkina
  • A V Liechtenstein
  • V E Gurtsevich
  • Vopr. Virusol..2019;64(5):229-237. doi: 10.36233/0507-4088-2019-64-5-229-237.

メデトミジン塩酸塩を末梢性α-アドレナリン受容体拮抗薬バチノキサン塩酸塩を併用または併用せずに投与したイヌにおけるアチパメゾールの筋肉内投与による心血管および鎮静の逆転効果

Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α-adrenoceptor antagonist vatinoxan hydrochloride.
  • Heta Turunen
  • Marja R Raekallio
  • Juhana M Honkavaara
  • Flavia Restitutti
  • Ira J Kallio-Kujala
  • Magdy Adam
  • Katri Nevanperä
  • Mika Scheinin
  • Sofia K Männikkö
  • Heidi J Hautajärvi
  • Paula Larenza Menzies
  • Outi M Vainio
  • Am. J. Vet. Res..2019 Oct;80(10):912-922. doi: 10.2460/ajvr.80.10.912.

tPAの24時間以内の抗血小板療法:急性虚血性脳卒中に対して血栓摘出術とステント留置術の併用を必要とする患者から得られた教訓

Antiplatelet therapy within 24 hours of tPA: lessons learned from patients requiring combined thrombectomy and stenting for acute ischemic stroke.
  • Michael G Brandel
  • Yasmeen Elsawaf
  • Robert C Rennert
  • Jeffrey A Steinberg
  • David R Santiago-Dieppa
  • Arvin R Wali
  • Scott E Olson
  • J Scott Pannell
  • Alexander A Khalessi
  • J Cerebrovasc Endovasc Neurosurg.2020 Mar;22(1):1-7. jcen-22-1-1. doi: 10.7461/jcen.2020.22.1.1.Epub 2020-03-31.

ラットモデルにおけるレーザースペックルイメージングを用いた急性硬膜下血腫における開頭術時の皮質脳血流動態の可視化

Visualization of cortical cerebral blood flow dynamics during craniotomy in acute subdural hematoma using laser speckle imaging in a rat model.
  • Cheng Wang
  • Liang Xian
  • Xiangrong Chen
  • Zuanfang Li
  • Yi Fang
  • Weiming Xu
  • Liangfeng Wei
  • Weiqiang Chen
  • Shousen Wang
  • Brain Res..2020 Sep;1742:146901. S0006-8993(20)30257-2. doi: 10.1016/j.brainres.2020.146901.Epub 2020-05-20.

4種類の抗精神病薬の血漿中濃度から推定したドパミンD2受容体占有率と、統合失調症における身体的・精神的幸福感の主観的経験。無作為化NeSSy試験の結果

Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial.
  • Tanja Veselinović
  • Martin Scharpenberg
  • Martin Heinze
  • Joachim Cordes
  • Bernd Mühlbauer
  • Georg Juckel
  • Eckart Rüther
  • Michael Paulzen
  • Ekkehard Haen
  • Christoph Hiemke
  • Jürgen Timm
  • Gerhard Gründer
  • J Clin Psychopharmacol.2019 Nov/Dec;39(6):550-560. doi: 10.1097/JCP.0000000000001131.

3.0テスラMRIスキャナーによるKlingler法で固定した死後ヒト脳半球の大脳皮質上大白質路と中心核の解剖学的構造の評価

3.0 Tesla MRI scanner evaluation of supratentorial major white matter tracts and central core anatomical structures of postmortem human brain hemispheres fixed by Klingler method.
  • Murat Atar
  • Ceren Kizmazoglu
  • Ismail Kaya
  • Nevin Aydin
  • Ufuk Corumlu
  • Gulden Sozer
  • Hasan Emre Aydin
  • Orhan Kalemci
  • Nuri Karabay
  • Nurullah Yuceer
  • Br J Neurosurg.2020 Jul;:1-5. doi: 10.1080/02688697.2020.1779179.Epub 2020-07-16.

新規の非胆汁酸系FXRアゴニストであるEDP-305は、胆管反応を悪化させることなく、肝障害や線維化を強力に抑制します

A novel non-bile acid FXR agonist EDP-305 potently suppresses liver injury and fibrosis without worsening of ductular reaction.
  • Ping An
  • Guangyan Wei
  • Pinzhu Huang
  • Wenda Li
  • Xiaolong Qi
  • Yi Lin
  • Kahini A Vaid
  • Jun Wang
  • Shucha Zhang
  • Yang Li
  • Yat Sun Or
  • Li-Juan Jiang
  • Yury V Popov
  • Liver Int..2020 Jul;40(7):1655-1669. doi: 10.1111/liv.14490.Epub 2020-05-06.

USP18のノックダウンはα2aインターフェロンシグナル伝達およびインターフェロン刺激遺伝子の誘導を増加させるが、Huh7細胞における抗ウイルス活性は増加しない

Knockdown of USP18 increases α 2a interferon signaling and induction of interferon-stimulating genes but does not increase antiviral activity in Huh7 cells.
  • E J Murray
  • Frances Burden
  • Nigel Horscroft
  • Caroline Smith-Burchnell
  • Mike Westby
  • Antimicrob. Agents Chemother..2011 Sep;55(9):4311-9. AAC.00644-11. doi: 10.1128/AAC.00644-11.Epub 2011-06-27.

Y染色体の組み立てにより、性染色体進化の収束的な特徴が明らかになった

Assembly of the threespine stickleback Y chromosome reveals convergent signatures of sex chromosome evolution.
  • Catherine L Peichel
  • Shaugnessy R McCann
  • Joseph A Ross
  • Alice F S Naftaly
  • James R Urton
  • Jennifer N Cech
  • Jane Grimwood
  • Jeremy Schmutz
  • Richard M Myers
  • David M Kingsley
  • Michael A White
  • Genome Biol..2020 Jul;21(1):177. 10.1186/s13059-020-02097-x. doi: 10.1186/s13059-020-02097-x.Epub 2020-07-19.

低侵襲な頸椎手術と前頸椎椎椎間板切除術および癒合術後の隣接セグメントのバイオメカニクスの比較解析。有限要素法による研究

Comparative analysis of the biomechanics of the adjacent segments after minimally invasive cervical surgeries versus anterior cervical discectomy and fusion: A finite element study.
  • Chao Chen
  • Chen-Xi Yuchi
  • Ziwei Gao
  • Xinlong Ma
  • Dong Zhao
  • Jun-Wei Li
  • Baoshan Xu
  • Chun-Qiu Zhang
  • Zheng Wang
  • Cheng-Fei Du
  • Qiang Yang
  • J Orthop Translat.2020 Jul;23:107-112. S2214-031X(20)30036-X. doi: 10.1016/j.jot.2020.03.006.Epub 2020-04-02.

新しいZOLを担持したゼラチンNP一体型多孔質チタン足場を用いた骨形成と骨吸収の調節.骨粗鬆症性骨欠損症の骨再生は、骨再生医療の大きな課題となっています

Modulation of bone formation and resorption using a novel ZOL loaded gelatin NPs integrated porous titanium scaffold: An<i> in vitro</i> and <i>in vivo</i> study.
  • Xiao-Jiang Yang
  • Chang-Bo Lu
  • Ji-Wei Zou
  • Fa-Qi Wang
  • Jin-Bo Hu
  • Zhao Yang
  • Hong-Xun Sang
  • Yang Zhang
  • Biomed Mater.2020 Apr;doi: 10.1088/1748-605X/ab8720.Epub 2020-04-06.

レバノンの女性における性感染症の分子疫学と社会・人口統計学的危険因子

Molecular epidemiology and socio-demographic risk factors of sexually transmitted infections among women in Lebanon.
  • Jessica Hanna
  • Ruba Yassine
  • Rana El-Bikai
  • Martin D Curran
  • Mathilde Azar
  • Joumana Yeretzian
  • Rana Skaf
  • Claude Afif
  • Toufic Saber
  • Saadeddine Itani
  • Manal Hubeish
  • Tamima El Jisr
  • Fadia Hamzeh
  • Mira El Chaar
  • BMC Infect. Dis..2020 May;20(1):375. 10.1186/s12879-020-05066-8. doi: 10.1186/s12879-020-05066-8.Epub 2020-05-27.

KHDC3Lの突然変異が再発性の胞状奇胎を引き起こすと、卵母細胞でゲノムワイドなDNAメチル化欠損を引き起こし、受精後も持続的なインプリンティング欠損を引き起こすことがわかった

A KHDC3L mutation resulting in recurrent hydatidiform mole causes genome-wide DNA methylation loss in oocytes and persistent imprinting defects post-fertilisation.
  • Hannah Demond
  • Zahra Anvar
  • Bahia Namavar Jahromi
  • Angela Sparago
  • Ankit Verma
  • Maryam Davari
  • Luciano Calzari
  • Silvia Russo
  • Mojgan Akbarzadeh Jahromi
  • David Monk
  • Simon Andrews
  • Andrea Riccio
  • Gavin Kelsey
  • Genome Med.2019 12;11(1):84. 10.1186/s13073-019-0694-y. doi: 10.1186/s13073-019-0694-y.Epub 2019-12-17.

血清中に循環する低分子の活性混合物は、ERストレスを介して癌細胞の増殖を選択的に抑制し、アポトーシスを誘発する

Active mixture of serum-circulating small molecules selectively inhibits proliferation and triggers apoptosis in cancer cells via induction of ER stress.
  • Dalma Scheffer
  • Gyula Kulcsár
  • György Nagyéri
  • Marianna Kiss-Merki
  • Zoltán Rékási
  • Magnus Maloy
  • Tamás Czömpöly
  • Cell. Signal..2020 01;65:109426. S0898-6568(19)30222-0. doi: 10.1016/j.cellsig.2019.109426.Epub 2019-11-07.

ウレラバシフェラ葉のハイドロアルコール抽出物のげっ歯類における消化管保護活性

Gastroprotective activity of hydroalcoholic extract of the leaves of Urera baccifera in rodents.
  • Régis Carlos Benvenutti
  • Cristian Alex Dalla Vecchia
  • Gelvani Locateli
  • Patrícia Zanotelli Serpa
  • Junir Antonio Lutinski
  • Sinval Adalberto Rodrigues Junior
  • Vanessa Corralo
  • Max Vidal Gutiérrez
  • Wagner Vilegas
  • Lincon Bordignon Somensi
  • Bruna Longo
  • Jessica Ferreira Knihs
  • Luisa Mota da Silva
  • Sérgio Faloni de Andrade
  • Walter Antônio Roman Junior
  • J Ethnopharmacol.2020 Mar;250:112473. S0378-8741(19)32394-3. doi: 10.1016/j.jep.2019.112473.Epub 2019-12-11.

マウス創傷治癒異常モデルにおける単球による異所性骨化の制御

Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing.
  • Michael Sorkin
  • Amanda K Huber
  • Charles Hwang
  • William F Carson
  • Rajasree Menon
  • John Li
  • Kaetlin Vasquez
  • Chase Pagani
  • Nicole Patel
  • Shuli Li
  • Noelle D Visser
  • Yashar Niknafs
  • Shawn Loder
  • Melissa Scola
  • Dylan Nycz
  • Katherine Gallagher
  • Laurie K McCauley
  • Jiajia Xu
  • Aaron W James
  • Shailesh Agarwal
  • Stephen Kunkel
  • Yuji Mishina
  • Benjamin Levi
  • Nat Commun.2020 02;11(1):722. 10.1038/s41467-019-14172-4. doi: 10.1038/s41467-019-14172-4.Epub 2020-02-05.

畳み込みニューラルネットワークを用いたタッチスクリーンタイピング解析によるパーキンソン病の早期発見

Early Parkinson's Disease Detection via Touchscreen Typing Analysis using Convolutional Neural Networks.
  • Dimitrios Iakovakis
  • Jose A Diniz
  • Dhaval Trivedi
  • Ray K Chaudhuri
  • Leontios J Hadjileontiadis
  • Stelios Hadjidimitriou
  • Vasileios Charisis
  • Sevasti Bostanjopoulou
  • Zoe Katsarou
  • Lisa Klingelhoefer
  • Simone Mayer
  • Heinz Reichmann
  • Sofia B Dias
  • Conf Proc IEEE Eng Med Biol Soc.2019 07;2019:3535-3538. doi: 10.1109/EMBC.2019.8857211.

Waardenburg症候群を有する褐色細胞腫におけるアンフォールドタンパク応答マーカーの発現:症例報告

Expression of unfolded protein response markers in the pheochromocytoma with Waardenburg syndrome: a case report.
  • Shuhei Morita
  • Ken Takeshima
  • Hiroyuki Ariyasu
  • Yasushi Furukawa
  • Shohei Kishimoto
  • Tomoya Tsuji
  • Shinsuke Uraki
  • Hiroyuki Mishima
  • Akira Kinoshita
  • Yuichi Takahashi
  • Hidefumi Inaba
  • Hiroshi Iwakura
  • Hiroto Furuta
  • Masahiro Nishi
  • Asako Doi
  • Shin-Ichi Murata
  • Koh-Ichiro Yoshiura
  • Takashi Akamizu
  • BMC Endocr Disord.2020 Jun;20(1):90. 10.1186/s12902-020-00574-9. doi: 10.1186/s12902-020-00574-9.Epub 2020-06-22.

桿菌感染症に対するプラジカンテル60mg/kgを月3回投与することは、安全で効果的な治療レジメンである

Three monthly doses of 60 mg/kg praziquantel for Schistosoma haematobium infection is a safe and effective treatment regimen.
  • Samuel Nkansah Darko
  • Henry Hanson
  • Sampson Twumasi-Ankrah
  • Sandra Baffour-Awuah
  • Priscilla Adjei-Kusi
  • Denis Yar
  • Ellis Owusu-Dabo
  • BMC Infect. Dis..2020 May;20(1):323. 10.1186/s12879-020-05053-z. doi: 10.1186/s12879-020-05053-z.Epub 2020-05-06.

臍帯血幹細胞由来のCD16 NK細胞が抗CD47抗体を用いて急性リンパ芽球性白血病細胞を駆除しました

Cord blood stem cell derived CD16 NK cells eradicated acute lymphoblastic leukemia cells using with anti-CD47 antibody.
  • Behnaz Valipour
  • Ali Abedelahi
  • Elahe Naderali
  • Kobra Velaei
  • Aliakbar Movassaghpour
  • Mehdi Talebi
  • Soheila Montazersaheb
  • Mohammad Karimipour
  • Masoud Darabi
  • Hadi Chavoshi
  • Hojjatollah Nozad Charoudeh
  • Life Sci..2020 Feb;242:117223. S0024-3205(19)31151-8. doi: 10.1016/j.lfs.2019.117223.Epub 2019-12-24.

サイト固有の発生期間と長期水質データセットを用いた河川におけるピークペリフィトンの予測可能性の向上

Improved predictability of peak periphyton in rivers using site-specific accrual periods and long-term water quality datasets.
  • Catherine Kilroy
  • Tom Stephens
  • Michelle Greenwood
  • Janine Wech
  • Logan Brown
  • Abby Matthews
  • Maree Patterson
  • Mike Patterson
  • Sci. Total Environ..2020 Sep;736:139362. S0048-9697(20)32879-5. doi: 10.1016/j.scitotenv.2020.139362.Epub 2020-05-14.

インド中央ヒマラヤ地方で飼育されていたゴールデンマッシャー(Tor putitora (Hamilton, 1822))の幼魚における人獣共通感染症Fusarium oxysporumの発生について

The emergence of zoonotic Fusarium oxysporum infection in captive-reared fingerlings of golden mahseer, Tor putitora (Hamilton, 1822) from the central Himalayan region of India.
  • Sumanta Kumar Mallik
  • Neetu Shahi
  • Nupur Joshi
  • Kushagra Pant
  • Krishna Kala
  • Suresh Chandra
  • Debajit Sarma
  • Transbound Emerg Dis.2020 Mar;67(2):555-563. doi: 10.1111/tbed.13367.Epub 2019-09-30.

シスタチオニン-γ-リアーゼ(CSE)の発現低下は、脂肪細胞や脂肪組織における高グルコース誘導MMP14の発現に関与している

Reduced cystathionine-γ-lyase (CSE) expression is involved in high glucose induced MMP14 expression in adipocytes and adipose tissues.
  • Tian-Xiao Hu
  • You-Liang Si
  • Yun Ruan
  • Xiu-Jing Wang
  • Jia-Qi Yao
  • Hui-Ling Wang
  • Yao Xu
  • Xin Ni
  • Qing-Ying Tan
  • Jing Wang
  • Endocr. J..2019 Nov;66(11):1029-1037. doi: 10.1507/endocrj.EJ19-0017.Epub 2019-08-01.

フラグメントベースのスクリーニングによる初のMycobacterium tuberculosis MabA(FabG1)阻害剤の発見

Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening.
  • Léo Faïon
  • Kamel Djaout
  • Rosangela Frita
  • Catalin Pintiala
  • Francois-Xavier Cantrelle
  • Martin Moune
  • Alexandre Vandeputte
  • Kevin Bourbiaux
  • Catherine Piveteau
  • Adrien Herledan
  • Alexandre Biela
  • Florence Leroux
  • Laurent Kremer
  • Mickael Blaise
  • Abdalkarim Tanina
  • René Wintjens
  • Xavier Hanoulle
  • Benoit Déprez
  • Nicolas Willand
  • Alain R Baulard
  • Marion Flipo
  • Eur J Med Chem.2020 Aug;200:112440. S0223-5234(20)30411-6. doi: 10.1016/j.ejmech.2020.112440.Epub 2020-05-18.

CCL3-CCR5 軸は、Akt および ERK 経路を介した細胞移動と浸潤を促進することで、食道扁平上皮癌の進行に寄与している

CCL3-CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways.
  • Takayuki Kodama
  • Yu-Ichiro Koma
  • Noriaki Arai
  • Aya Kido
  • Naoki Urakawa
  • Mari Nishio
  • Manabu Shigeoka
  • Hiroshi Yokozaki
  • Lab. Invest..2020 May;10.1038/s41374-020-0441-4. doi: 10.1038/s41374-020-0441-4.Epub 2020-05-26.

長いノンコーディングRNA VIM-AS1のノックダウンは神経膠腫細胞の増殖と遊走を抑制し、miR-105-5pを標的としたWEE1の調節を介して細胞のアポトーシスを増加させる

Knockdown of long non-coding RNA VIM-AS1 inhibits glioma cell proliferation and migration, and increases the cell apoptosis via modulation of WEE1 targeted by miR-105-5p.
  • S-T Suo
  • P Gong
  • X-J Peng
  • D Niu
  • Y-T Guo
  • Eur Rev Med Pharmacol Sci.2020 Jun;24(12):6834-6847. 21673. doi: 10.26355/eurrev_202006_21673.

慢性骨髄球性白血病の移植を受けた患者において、TBIに基づく条件付けとミコフェノレートモフェチル含有免疫抑制後の高白血病無血生存率:単一施設での経験

High leukemia-free survival after TBI-based conditioning and mycophenolate mofetil-containing immunosuppression in patients allografted for chronic myelomonocytic leukemia: a single-center experience.
  • Aleksandar Radujkovic
  • Ute Hegenbart
  • Carsten Müller-Tidow
  • Klaus Herfarth
  • Peter Dreger
  • Thomas Luft
  • Ann. Hematol..2020 Apr;99(4):855-866. 10.1007/s00277-020-03952-4. doi: 10.1007/s00277-020-03952-4.Epub 2020-02-08.

5-リポキシゲナーゼ活性化蛋白質と可溶性エポキシドヒドロラーゼの最初のデュアル阻害剤であるdiflapolinの薬理学的プロファイルとin vivoでの効率

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.
  • Ulrike Garscha
  • Erik Romp
  • Simona Pace
  • Antonietta Rossi
  • Veronika Temml
  • Daniela Schuster
  • Stefanie König
  • Jana Gerstmeier
  • Stefanie Liening
  • Markus Werner
  • Heiner Atze
  • Sandra Wittmann
  • Christina Weinigel
  • Silke Rummler
  • Gerhard K Scriba
  • Lidia Sautebin
  • Oliver Werz
  • Sci Rep.2017 08;7(1):9398. 10.1038/s41598-017-09795-w. doi: 10.1038/s41598-017-09795-w.Epub 2017-08-24.

バクテリアGH39 β-キシロシダーゼの基質親和性と構造安定性の分子基盤を探る

Exploring the Molecular Basis for Substrate Affinity and Structural Stability in Bacterial GH39 β-Xylosidases.
  • Mariana Abrahão Bueno de Morais
  • Carla Cristina Polo
  • Mariane Noronha Domingues
  • Gabriela Felix Persinoti
  • Renan Augusto Siqueira Pirolla
  • Flávio Henrique Moreira de Souza
  • Jessica Batista de Lima Correa
  • Camila Ramos Dos Santos
  • Mário Tyago Murakami
  • Front Bioeng Biotechnol.2020;8:419. doi: 10.3389/fbioe.2020.00419.Epub 2020-05-15.

非びらん性逆流症の診断における食道ベースラインインピーダンスレベルの有用性と、韓国の食道症状または上食道症状を有する内視鏡陰性患者における適切な測定時期

The Usefulness of Esophageal Baseline Impedance Levels for the Diagnosis of Nonerosive Reflux Disease and the Proper Time for Measurement in Endoscopy-negative Korean Patients With Esophageal or Supraesophageal Symptoms.
  • Young-Gun Kim
  • Choong-Kyun Noh
  • Kwang Jae Lee
  • J Neurogastroenterol Motil.2020 Jun;jnm20019. doi: 10.5056/jnm20019.Epub 2020-06-29.

フォウルポックスウイルスBCL-2ホモログ、FPV039は、活性化されたBaxおよびBH3のみのタンパク質の離散的なサブセットと相互作用してアポトーシスを阻害する

The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis.
  • Logan Banadyga
  • Kirstin Veugelers
  • Stephanie Campbell
  • Michele Barry
  • J. Virol..2009 Jul;83(14):7085-98. JVI.00437-09. doi: 10.1128/JVI.00437-09.Epub 2009-05-13.

ポリエチレングリコールを模擬した干ばつストレスに対する耐性が対照的な Eruca vesicaria subs. sativa 系統のトランスクリプトーム解析

Transcriptomic analysis of Eruca vesicaria subs. sativa lines with contrasting tolerance to polyethylene glycol-simulated drought stress.
  • Bang-Lian Huang
  • Xuan Li
  • Pei Liu
  • Lan Ma
  • Wenhua Wu
  • Xuekun Zhang
  • Zaiyun Li
  • Bangquan Huang
  • BMC Plant Biol..2019 Oct;19(1):419. 10.1186/s12870-019-1997-2. doi: 10.1186/s12870-019-1997-2.Epub 2019-10-11.