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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

非骨髄芽腫性β-サラサラ血症マウスにおけるβ-サラサラ血症患者由来の遺伝的に補正されたiPSCの安全性と有効性

The safety and effectiveness of genetically corrected iPSCs derived from β-thalassaemia patients in nonmyeloablative β-thalassaemic mice.
  • Yexing Xian
  • Yingjun Xie
  • Bing Song
  • Zhanhui Ou
  • Shuming Ouyang
  • Yuhuan Xie
  • Yi Yang
  • Zeyu Xiong
  • Haoxian Li
  • Xiaofang Sun
  • Stem Cell Res Ther.2020 Jul;11(1):288. 10.1186/s13287-020-01765-w. doi: 10.1186/s13287-020-01765-w.Epub 2020-07-16.

脳微小透析研究のためのバイオマトリックス中の物理化学的特性と未結合画分に基づく中枢神経系薬剤候補の除外

Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations.
  • Qianwen Wang
  • Tianjing Ren
  • Jiajia Zhao
  • Chun-Ho Wong
  • H Y Edwin Chan
  • Zhong Zuo
  • J Pharm Biomed Anal.2020 Jan;178:112946. S0731-7085(19)30281-X. doi: 10.1016/j.jpba.2019.112946.Epub 2019-10-25.

Brachiaria brizanthaへのEnterolobium cyclocarpumポッドおよびGliricidia sepium飼料の添加が乾物分解、揮発性脂肪酸濃度、およびin vitroメタン生産に及ぼす影響

Effect of the addition of Enterolobium cyclocarpum pods and Gliricidia sepium forage to Brachiaria brizantha on dry matter degradation, volatile fatty acid concentration, and in vitro methane production.
  • Isabel Cristina Molina-Botero
  • Johanna Mazabel
  • Jeyder Arceo-Castillo
  • José Luis Urrea-Benítez
  • Leticia Olivera-Castillo
  • Rolando Barahona-Rosales
  • Ngonidzashe Chirinda
  • Juan Ku-Vera
  • Jacobo Arango
  • Trop Anim Health Prod.2020 Jul;10.1007/s11250-020-02324-4. doi: 10.1007/s11250-020-02324-4.Epub 2020-07-09.

TOR1AIP1-associated nuclear envelopathiesの表現型をさらに拡大した2つの新規症例

Two novel cases further expand the phenotype of TOR1AIP1-associated nuclear envelopathies.
  • Ivana Lessel
  • Mei-Jan Chen
  • Sabine Lüttgen
  • Florian Arndt
  • Sigrid Fuchs
  • Stefanie Meien
  • Holger Thiele
  • Julie R Jones
  • Brandon R Shaw
  • David K Crossman
  • Peter Nürnberg
  • Bruce R Korf
  • Christian Kubisch
  • Davor Lessel
  • Hum. Genet..2020 Apr;139(4):483-498. 10.1007/s00439-019-02105-6. doi: 10.1007/s00439-019-02105-6.Epub 2020-02-13.

リトアニアの IPV ワクチン接種児を対象とした 1 価経口 2 型サビンポリオワクチン接種後の免疫原性と安全性に関する無作為化第 4 相試験

A randomized phase 4 study of immunogenicity and safety following monovalent oral type 2 Sabin polio vaccine challenge in IPV-vaccinated children in Lithuania.
  • Ananda S Bandyopadhyay
  • Chris Gast
  • Elizabeth B Brickley
  • Ricardo Rüttimann
  • Ralf Clemens
  • M Steven Oberste
  • William C Weldon
  • Margaret E Ackerman
  • Ruth I Connor
  • Wendy F Wieland-Alter
  • Peter Wright
  • Vytautas Usonis
  • J. Infect. Dis..2020 Jul;jiaa390. doi: 10.1093/infdis/jiaa390.Epub 2020-07-04.

根管形成における交渉、グライドパス、プレフレアの手順が根管形成に与える影響-用語、基本概念、および系統的なレビュー

Influence of Negotiation, Glide Path, and Preflaring Procedures on Root Canal Shaping-Terminology, Basic Concepts, and a Systematic Review.
  • Gianluca Plotino
  • Venkateshbabu Nagendrababu
  • Frederic Bukiet
  • Nicola M Grande
  • Sajesh K Veettil
  • Gustavo De-Deus
  • Hany Mohamed Aly Ahmed
  • J Endod.2020 Jun;46(6):707-729. S0099-2399(20)30076-5. doi: 10.1016/j.joen.2020.01.023.Epub 2020-04-22.

骨粗鬆症性椎体圧迫骨折(OVCF)患者の治療における片側と両側の経皮的弯曲術の比較:システマティックレビューとメタアナリシス

Comparison of unilateral versus bilateral percutaneous kyphoplasty for the treatment of patients with osteoporosis vertebral compression fracture (OVCF): a systematic review and meta-analysis.
  • Xing Cheng
  • Hou-Qing Long
  • Jing-Hui Xu
  • Yang-Liang Huang
  • Fo-Bao Li
  • Eur Spine J.2016 11;25(11):3439-3449. 10.1007/s00586-016-4395-6. doi: 10.1007/s00586-016-4395-6.Epub 2016-01-27.

5αリダクターゼ阻害剤の共投与は、処方されたグルココルチコイドの有害な代謝作用を悪化させる

Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids.
  • Nantia Othonos
  • Thomas Marjot
  • Conor Woods
  • Jonathan M Hazlehurst
  • Nikolaos Nikolaou
  • Riccardo Pofi
  • Sarah White
  • Ilaria Bonaventura
  • Craig Webster
  • Joanne Duffy
  • Thomas Cornfield
  • Ahmad Moolla
  • Andrea M Isidori
  • Leanne Hodson
  • Jeremy W Tomlinson
  • J. Clin. Endocrinol. Metab..2020 Jun;dgaa408. doi: 10.1210/clinem/dgaa408.Epub 2020-06-27.

ルネッサンスへの準備:COVID-19パンデミック時の乳がんの治療と、ユニバーサル・ヘルスケア・システム内での日常的な外科的ケアへの安全な再浮上のための計画

Preparing for the renaissance: treating breast cancer during the COVID-19 pandemic and planning for a safe re-emergence to routine surgical care within a universal health care system.
  • D Berger-Richardson
  • G Ko
  • N J Look Hong
  • Curr Oncol.2020 06;27(3):163-168. conc-27-163. doi: 10.3747/co.27.6699.Epub 2020-06-01.

ソニックヘッジホッグ/Gli経路転写標的であるNeogenin-1のダウンレギュレーションは、基底細胞癌の攻撃性と関連している

Downregulation of the Sonic Hedgehog/Gli pathway transcriptional target Neogenin-1 is associated with basal cell carcinoma aggressiveness.
  • Bárbara S Casas
  • Christelle Adolphe
  • Pablo Lois
  • Nelson Navarrete
  • Natalia Solís
  • Eva Bustamante
  • Patricio Gac
  • Patricio Cabané
  • Ivan Gallegos
  • Brandon J Wainwright
  • Verónica Palma
  • Oncotarget.2017 Oct;8(48):84006-84018. 21061. doi: 10.18632/oncotarget.21061.Epub 2017-09-19.

心筋虚血が疑われる安定した外来患者におけるフローサイトメトリーに基づく血小板反応性の性差

Sex differences in flow cytometry-based platelet reactivity in stable outpatients suspected of myocardial ischemia.
  • Farahnaz Waissi
  • Mirthe Dekker
  • Ingrid E M Bank
  • Suzanne J A Korporaal
  • Rolf T Urbanus
  • Gert J de Borst
  • Gerard Pasterkamp
  • Asbjorn M Scholtens
  • Diederick E Grobbee
  • Arend Mosterd
  • Dominique P V de Kleijn
  • Leo Timmers
  • Res Pract Thromb Haemost.2020 Jul;4(5):879-885. RTH212344. doi: 10.1002/rth2.12344.Epub 2020-05-15.

一般的なバイオマーカーから導き出された有効な死亡率リスクスコアを用いて、退院後に病院関連の静脈血栓塞栓症を医療患者の間で予測する

Predicting postdischarge hospital-associated venous thromboembolism among medical patients using a validated mortality risk score derived from common biomarkers.
  • Lindsey Snyder
  • Scott M Stevens
  • Masarret Fazili
  • Emily L Wilson
  • James F Lloyd
  • Benjamin D Horne
  • Joseph Bledsoe
  • Scott C Woller
  • Res Pract Thromb Haemost.2020 Jul;4(5):872-878. RTH212343. doi: 10.1002/rth2.12343.Epub 2020-05-20.

ヤギにおける家畜化遺伝子の起源

The origin of domestication genes in goats.
  • Zhuqing Zheng
  • Xihong Wang
  • Ming Li
  • Yunjia Li
  • Zhirui Yang
  • Xiaolong Wang
  • Xiangyu Pan
  • Mian Gong
  • Yu Zhang
  • Yingwei Guo
  • Yu Wang
  • Jing Liu
  • Yudong Cai
  • Qiuming Chen
  • Moses Okpeku
  • Licia Colli
  • Dawei Cai
  • Kun Wang
  • Shisheng Huang
  • Tad S Sonstegard
  • Ali Esmailizadeh
  • Wenguang Zhang
  • Tingting Zhang
  • Yangbin Xu
  • Naiyi Xu
  • Yi Yang
  • Jianlin Han
  • Lei Chen
  • Joséphine Lesur
  • Kevin G Daly
  • Daniel G Bradley
  • Rasmus Heller
  • Guojie Zhang
  • Wen Wang
  • Yulin Chen
  • Yu Jiang
  • Sci Adv.2020 May;6(21):eaaz5216. aaz5216. doi: 10.1126/sciadv.aaz5216.Epub 2020-05-20.

コネクトベースのモデルは大うつ病性障害の初期症状改善を予測できる

Connectome-based models can predict early symptom improvement in major depressive disorder.
  • Yumeng Ju
  • Corey Horien
  • Wentao Chen
  • Weilong Guo
  • Xiaowen Lu
  • Jinrong Sun
  • Qiangli Dong
  • Bangshan Liu
  • Jin Liu
  • Danfeng Yan
  • Mi Wang
  • Liang Zhang
  • Hua Guo
  • Futao Zhao
  • Yan Zhang
  • Xilin Shen
  • R Todd Constable
  • Lingjiang Li
  • J Affect Disord.2020 Aug;273:442-452. S0165-0327(20)30620-0. doi: 10.1016/j.jad.2020.04.028.Epub 2020-05-11.

抗ミューレリアンホルモンと卵胞数は、POSEIDON群3および4の患者における最初の完全卵巣刺激サイクルの累積治療成績を予測する能力に違いがある

Anti-Müllerian hormone and antral follicle count differ in their ability to predict cumulative treatment outcomes of the first complete ovarian stimulation cycle in patients from POSEIDON groups 3 and 4.
  • Luxin Liu
  • Canquan Zhou
  • J. Obstet. Gynaecol. Res..2020 Jul;doi: 10.1111/jog.14269.Epub 2020-07-19.

経皮的冠動脈インターベンションを受けた中国人急性冠症候群患者に対するチカグレラーとクロピドグレルの有効性評価をデータマイニングと機械学習による決定木アプローチで行った

Efficacy assessment of ticagrelor versus clopidogrel in Chinese patients with acute coronary syndrome undergoing percutaneous coronary intervention by data mining and machine-learning decision tree approaches.
  • Ying Xue
  • Ziheng Hu
  • Yankang Jing
  • Hongyi Wu
  • Xiaoye Li
  • Junmei Wang
  • Amy Seybert
  • Xiangqun Xie
  • Qianzhou Lv
  • J Clin Pharm Ther.2020 Jul;doi: 10.1111/jcpt.13172.Epub 2020-07-06.

アンキリンリピートドメイン(R635X)の病原性NFKB2変異体は可変抗体欠損症を引き起こす

Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency.
  • Paul Tuijnenburg
  • Hana Lango Allen
  • Godelieve J de Bree
  • Sinisa Savic
  • Machiel H Jansen
  • Claire Stockdale
  • Ilenia Simeoni
  • Ineke J M Ten Berge
  • Ester M M van Leeuwen
  • James E Thaventhiran
  • Taco W Kuijpers
  • Clin. Immunol..2019 06;203:23-27. S1521-6616(18)30590-4. doi: 10.1016/j.clim.2019.03.010.Epub 2019-04-03.

日常診療における関節リウマチインパクト(RAID)の使用;DAS28寛解とアンメット患者報告アウトカムの同定

Use of rheumatoid arthritis impact of disease (RAID) in routine care; identification of DAS28 remission and unmet patient-reported outcomes.
  • Jatin Mistry
  • Mohammed Sharif
  • Amy Prideaux
  • Catherine Smith
  • Malama Sumbwanyambe
  • Margaret Sibley
  • Lewis Carpenter
  • Melissa Sweeney
  • Patrick Kiely
  • Rheumatol Adv Pract.2020;4(2):rkaa013. rkaa013. doi: 10.1093/rap/rkaa013.Epub 2020-04-27.

循環性腫瘍細胞を有するHER2非増幅型早期乳癌(EORTC 90091-10093、BIG 1-12、Treat CTC)に対するトラスツズマブと観察の比較:無作為化第II相試験

Trastuzumab versus observation for HER2 nonamplified early breast cancer with circulating tumor cells (EORTC 90091-10093, BIG 1-12, Treat CTC): a randomized phase II trial.
  • M Ignatiadis
  • S Litière
  • F Rothe
  • S Riethdorf
  • C Proudhon
  • T Fehm
  • K Aalders
  • H Forstbauer
  • P A Fasching
  • E Brain
  • P Vuylsteke
  • E Guardiola
  • R Lorenz
  • K Pantel
  • K Tryfonidis
  • W Janni
  • M Piccart
  • C Sotiriou
  • B Rack
  • J-Y Pierga
  • Ann. Oncol..2018 08;29(8):1777-1783. S0923-7534(19)34129-8. doi: 10.1093/annonc/mdy211.

内視鏡支援下顎切除術。手術手技と手術縁のコントロール

Endoscopic-assisted maxillectomy: Operative technique and control of surgical margins.
  • Alberto Deganello
  • Marco Ferrari
  • Alberto Paderno
  • Mario Turri-Zanoni
  • Alberto Schreiber
  • Davide Mattavelli
  • Alperen Vural
  • Vittorio Rampinelli
  • Alberto Daniele Arosio
  • Alessandro Ioppi
  • Mario Cherubino
  • Paolo Castelnuovo
  • Piero Nicolai
  • Paolo Battaglia
  • Oral Oncol..2019 06;93:29-38. S1368-8375(19)30102-2. doi: 10.1016/j.oraloncology.2019.04.002.Epub 2019-04-11.

マングローブクラブGoniopsis cruentata(Brachyura, Grapsidae)のエラにおける(Na, K)-ATPase活性の生化学的特性とマグネシウムによるアロステリックな調節

Biochemical Characterization and Allosteric Modulation by Magnesium of (Na, K)-ATPase Activity in the Gills of the Red Mangrove Crab Goniopsis cruentata (Brachyura, Grapsidae).
  • Cintya M Moraes
  • Malson N Lucena
  • Daniela P Garçon
  • Marcelo R Pinto
  • Leonardo M Fabri
  • Rogério O Faleiros
  • Carlos F L Fontes
  • John C McNamara
  • Francisco A Leone
  • J. Membr. Biol..2020 Jun;253(3):229-245. 10.1007/s00232-020-00120-7. doi: 10.1007/s00232-020-00120-7.Epub 2020-05-22.

STING依存性パラクリニーは抗ミトックス治療に応答して乳房腫瘍のアポトーシスプライミングを形成する

STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment.
  • Steven Lohard
  • Nathalie Bourgeois
  • Laurent Maillet
  • Fabien Gautier
  • Aurélie Fétiveau
  • Hamza Lasla
  • Frédérique Nguyen
  • Céline Vuillier
  • Alison Dumont
  • Agnès Moreau-Aubry
  • Morgane Frapin
  • Laurent David
  • Delphine Loussouarn
  • Olivier Kerdraon
  • Mario Campone
  • Pascal Jézéquel
  • Philippe P Juin
  • Sophie Barillé-Nion
  • Nat Commun.2020 01;11(1):259. 10.1038/s41467-019-13689-y. doi: 10.1038/s41467-019-13689-y.Epub 2020-01-14.

グルココルチコイドが白血病細胞におけるBCL-Xの発現制御にASH2Lが重要な役割を果たすことを明らかにした

Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells.
  • Luciana Rocha-Viegas
  • Micaela Silbermins
  • María Florencia Ogara
  • Joaquín Miguel Pellegrini
  • Sol Yanel Nuñez
  • Verónica Edith García
  • Guillermo Pablo Vicent
  • Adali Pecci
  • Biochim Biophys Acta Gene Regul Mech.2020 01;1863(1):194475. S1874-9399(19)30112-9. doi: 10.1016/j.bbagrm.2019.194475.Epub 2019-12-20.

BRAG2aはPSD-95およびエンドフィリン3との相互作用を介して興奮性ポストシナプスにおけるmGluR依存性AMPA受容体の内部化を媒介している

BRAG2a Mediates mGluR-Dependent AMPA Receptor Internalization at Excitatory Postsynapses through the Interaction with PSD-95 and Endophilin 3.
  • Masahiro Fukaya
  • Takeyuki Sugawara
  • Yoshinobu Hara
  • Makoto Itakura
  • Masahiko Watanabe
  • Hiroyuki Sakagami
  • J. Neurosci..2020 May;40(22):4277-4296. JNEUROSCI.1645-19.2020. doi: 10.1523/JNEUROSCI.1645-19.2020.Epub 2020-04-27.

産地の農場で赤外線サーモグラフィーを使用して、輸送やマーケティングにさらされた牛(Bos Taurus)の肉質と生理的反応を予測する

Using infrared thermography on farm of origin to predict meat quality and physiological response in cattle (Bos Taurus) exposed to transport and marketing.
  • Holly Cuthbertson
  • Garth Tarr
  • Kate Loudon
  • Sabrina Lomax
  • Peter White
  • Paul McGreevy
  • Rodney Polkinghorne
  • Luciano A González
  • Meat Sci..2020 Apr;169:108173. S0309-1740(19)30265-7. doi: 10.1016/j.meatsci.2020.108173.Epub 2020-04-29.

クリティカルケアを支える学生たち-COVID-19パンデミックにおけるICUの腐敗を防ぐためのコンテンションプラン:ビョルン・イプセンスのポリオレスを現代に翻訳する

Students Supporting Critical Care - A contention plan to prevent the decompensation of ICUs in the COVID-19 pandemic:Translating Bjorn Ibsens' polio-lessons to modern times.
  • Pedro David Wendel Garcia
  • Paola Massarotto
  • Katja Auinger
  • Reto Andreas Schuepbach
  • Stephanie Klinzing
  • Crit Care.2020 05;24(1):211. 10.1186/s13054-020-02919-1. doi: 10.1186/s13054-020-02919-1.Epub 2020-05-08.

妊娠低酸素は、小胞体/酸化ストレスの増加を介して子宮動脈のCaスパークと自発的な一過性の外向き電流の妊娠誘発性アップレギュレーションを抑制する

Gestational Hypoxia Inhibits Pregnancy-Induced Upregulation of Ca Sparks and Spontaneous Transient Outward Currents in Uterine Arteries Via Heightened Endoplasmic Reticulum/Oxidative Stress.
  • Xiang-Qun Hu
  • Rui Song
  • Monica Romero
  • Chiranjib Dasgupta
  • Joseph Min
  • Daisy Hatcher
  • Daliao Xiao
  • Arlin Blood
  • Sean M Wilson
  • Lubo Zhang
  • Hypertension.2020 Jul;:HYPERTENSIONAHA12015235. doi: 10.1161/HYPERTENSIONAHA.120.15235.Epub 2020-07-20.

MCK1は、気分安定剤バルプロ酸によるイノシトール合成の阻害に必要なミオイノシトールリン酸合成酵素(MIPS)の新規調節因子である

MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition of inositol synthesis by the mood stabilizer valproate.
  • Wenxi Yu
  • Joshua Daniel
  • Dhara Mehta
  • Krishna Rao Maddipati
  • Miriam L Greenberg
  • PLoS ONE.2017;12(8):e0182534. PONE-D-17-20676. doi: 10.1371/journal.pone.0182534.Epub 2017-08-17.

CYP2C9およびCYP2C19の多型がプロゲステロン経口投与または膣内投与されたプロゲステロンの投薬、安全性および代謝に及ぼす影響」に対する編集者へのレター

Letter to the Editor in Response to "Effect of Polymorphisms in CYP2C9 and CYP2C19 on the Disposition, Safety and Metabolism of Progesterone Administrated Orally or Vaginally".
  • Aaron Lazorwitz
  • Christina L Aquilante
  • Jeanelle Sheeder
  • Stephanie Teal
  • Adv Ther.2020 02;37(2):963-964. 10.1007/s12325-019-01195-y. doi: 10.1007/s12325-019-01195-y.Epub 2019-12-24.

糖尿病網膜症ラットにおいて、miR-34αを阻害することで、HMGB1の発現を調節することで網膜細胞のアポトーシスと下流のNF-κB経路を減少させることができました

Inhibiting MiR-34α reduces retinal cell apoptosis and downstream NF-κB pathway in diabetic retinopathy rats through regulating HMGB1 expression.
  • Yibin Ma
  • Yunhong Du
  • Qian Xu
  • Huijing Bao
  • Zhonglian Liu
  • Yingchao Li
  • Wenjing Liu
  • Minerva Med..2020 Jul;S0026-4806.20.06625-2. doi: 10.23736/S0026-4806.20.06625-2.Epub 2020-07-17.

レニン-アンジオテンシン系阻害剤投与下でのレニン-アンジオテンシン-アルドステロン系に対するダパグリフロジンの効果

Effects of dapagliflozin on renin-angiotensin-aldosterone system under renin-angiotensin system inhibitor administration.
  • Masashi Isshiki
  • Ichiro Sakuma
  • Yasuaki Hayashino
  • Takashi Sumita
  • Kazuo Hara
  • Kazuhisa Takahashi
  • Ichiro Shiojima
  • Noriko Satoh-Asahara
  • Hiroji Kitazato
  • Daisuke Ito
  • Daigo Saito
  • Masako Hatano
  • Yuichi Ikegami
  • Shinichiro Iida
  • Akira Shimada
  • Mitsuhiko Noda
  • Endocr. J..2020 Jul;doi: 10.1507/endocrj.EJ20-0222.Epub 2020-07-01.

RNA崩壊因子であるCCR4は、植物サイトラブウイルスのホスホタンパク質によってハイジャックされ、ウイルスの複製を促進する

CCR4, a RNA decay factor, is hijacked by a plant cytorhabdovirus phosphoprotein to facilitate virus replication.
  • Zhen-Jia Zhang
  • Qiang Gao
  • Xiao-Dong Fang
  • Zhi-Hang Ding
  • Dong-Min Gao
  • Wen-Ya Xu
  • Qing Cao
  • Ji-Hui Qiao
  • Yi-Zhou Yang
  • Chenggui Han
  • Ying Wang
  • Xuefeng Yuan
  • Dawei Li
  • Xian-Bing Wang
  • Elife.2020 Mar;9. e53753. doi: 10.7554/eLife.53753.Epub 2020-03-24.

刻々と変化する世界の髄膜炎球菌疾患の疫学と、ワクチン接種による予防の可能性

The everchanging epidemiology of meningococcal disease worldwide and the potential for prevention through vaccination.
  • Sydel Parikh
  • Helen Campbell
  • Julie A Bettinger
  • Lee H Harrison
  • Helen S Marshall
  • Federico Martinon-Torres
  • Marco Aurelio Safadi
  • Zhujun Shao
  • Bingqing Zhu
  • Anne von Gottberg
  • Ray Borrow
  • Mary E Ramsay
  • Shamez N Ladhani
  • J. Infect..2020 Jun;S0163-4453(20)30378-9. doi: 10.1016/j.jinf.2020.05.079.Epub 2020-06-03.

COVID-19の重症度における内臓脂肪率の役割:ドイツにおける単施設横断的パイロット研究のハイライト

The role of visceral adiposity in the severity of COVID-19: highlights from a unicenter cross-sectional pilot study in Germany.
  • Antonia Petersen
  • Keno Bressem
  • Jakob Albrecht
  • Hans-Martin Thieß
  • Janis Vahldiek
  • Bernd Hamm
  • Marcus R Makowski
  • Alexandra Niehues
  • Stefan Niehues
  • Lisa C Adams
  • Metab. Clin. Exp..2020 Jul;:154317. S0026-0495(20)30181-5. doi: 10.1016/j.metabol.2020.154317.Epub 2020-07-13.

免疫関連の有害事象と免疫チェックポイント阻害薬の有効性 食品医薬品局が承認した免疫療法の適応を持つ消化器癌患者における免疫関連の有害事象と免疫チェックポイント阻害薬の有効性

Immune-Related Adverse Events and Immune Checkpoint Inhibitor Efficacy in Patients with Gastrointestinal Cancer with Food and Drug Administration-Approved Indications for Immunotherapy.
  • Satya Das
  • Kristen K Ciombor
  • Sigurdis Haraldsdottir
  • Yoanna Pumpalova
  • Ibrahim H Sahin
  • G Pineda
  • Yu Shyr
  • E P Lin
  • Chih-Yuan Hsu
  • Shih-Kai Chu
  • Laura W Goff
  • Dana B Cardin
  • Mehmet A Bilen
  • George A Fisher
  • Christina Wu
  • Jordan Berlin
  • Oncologist.2020 Jan;doi: 10.1634/theoncologist.2019-0637.Epub 2020-01-14.

イエルシニア・ペスティスにおけるバイオフィルムを媒介とした拡張表現型の進化的選択

Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment.
  • Yujun Cui
  • Boris V Schmid
  • Hanli Cao
  • Xiang Dai
  • Zongmin Du
  • W Ryan Easterday
  • Haihong Fang
  • Chenyi Guo
  • Shanqian Huang
  • Wanbing Liu
  • Zhizhen Qi
  • Yajun Song
  • Huaiyu Tian
  • Min Wang
  • Yarong Wu
  • Bing Xu
  • Chao Yang
  • Jing Yang
  • Xianwei Yang
  • Qingwen Zhang
  • Kjetill S Jakobsen
  • Yujiang Zhang
  • Nils Chr Stenseth
  • Ruifu Yang
  • Nat Commun.2020 01;11(1):281. 10.1038/s41467-019-14099-w. doi: 10.1038/s41467-019-14099-w.Epub 2020-01-15.

ニコチンアミドホスホリボシルトランスフェラーゼ(Nampt)/ニコチンアミドアデニンジヌクレオチド(NAD)軸は、カルシウムハンドリング経路を調節することで心房細動を抑制する

Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway.
  • Duo Feng
  • DongZhu Xu
  • Nobuyuki Murakoshi
  • Kazuko Tajiri
  • Rujie Qin
  • Saori Yonebayashi
  • Yuta Okabe
  • Siqi Li
  • Zixun Yuan
  • Kazutaka Aonuma
  • Masaki Ieda
  • Int J Mol Sci.2020 Jun;21(13). E4655. doi: 10.3390/ijms21134655.Epub 2020-06-30.

t-PA遺伝子のDNAメチル化は、電気けいれん療法を受けているうつ病患者から分離された様々な免疫細胞サブタイプの間で異なる

DNA Methylation of the t-PA Gene Differs Between Various Immune Cell Subtypes Isolated From Depressed Patients Receiving Electroconvulsive Therapy.
  • Nicole Moschny
  • Kirsten Jahn
  • Malek Bajbouj
  • Hannah Benedictine Maier
  • Matthias Ballmaier
  • Abdul Qayyum Khan
  • Christoph Pollak
  • Stefan Bleich
  • Helge Frieling
  • Alexandra Neyazi
  • Front Psychiatry.2020;11:571. doi: 10.3389/fpsyt.2020.00571.Epub 2020-06-19.

サイトメガロウイルス血清陽性と多発性硬化症の関連における地域差。システマティックレビューおよびメタアナリシス

Regional differences in the association of cytomegalovirus seropositivity and multiple sclerosis: A systematic review and meta-analysis.
  • Smathorn Thakolwiboon
  • Hannah Zhao-Fleming
  • Amputch Karukote
  • Pavida Pachariyanon
  • Hayley Gibler Williams
  • Mirla Avila
  • Mult Scler Relat Disord.2020 Jul;45:102393. S2211-0348(20)30468-5. doi: 10.1016/j.msard.2020.102393.Epub 2020-07-12.

リチウムイオン電池のための有望な負極材料としての2-カルボキシエチルゲルマニウムセスキオキシド

2-Carboxyethylgermanium Sesquioxide as A Promising Anode Material for Li-Ion Batteries.
  • Evgeniya A Saverina
  • Roman R Kapaev
  • Pavel V Stishenko
  • Alexey S Galushko
  • Victoriya A Balycheva
  • Valentine P Ananikov
  • Mikhail P Egorov
  • Viatcheslav V Jouikov
  • Pavel A Troshin
  • Mikhail A Syroeshkin
  • ChemSusChem.2020 Jun;13(12):3137-3146. doi: 10.1002/cssc.202000852.Epub 2020-05-26.

2種類以上の降圧薬を服用している無制御高血圧症患者を対象に、降圧薬の自己管理、血圧の自己測定、低カロリー・低ナトリウム食、身体運動からなる多因子介入の有効性。MEDICHY試験

Effectiveness of a multifactorial intervention, consisting of self-management of antihypertensive medication, self-measurement of blood pressure, hypocaloric and low sodium diet, and physical exercise, in patients with uncontrolled hypertension taking 2 or more antihypertensive drugs: The MEDICHY study.
  • Fabián Unda Villafuerte
  • Joan Llobera Cànaves
  • Patricia Lorente Montalvo
  • María Lucía Moreno Sancho
  • Bartolomé Oliver Oliver
  • Patricia Bassante Flores
  • Andreu Estela Mantolan
  • Joan Pou Bordoy
  • Tomás Rodríguez Ruiz
  • Ana Requena Hernández
  • Alfonso Leiva
  • Matíes Torrent Quetglas
  • José María Coll Benejam
  • Pilar D'Agosto Forteza
  • Fernando Rigo Carratalà
  • Medicine (Baltimore).2020 Apr;99(17):e19769. 00005792-202004240-00028. doi: 10.1097/MD.0000000000019769.

選択的LXRアゴニストDMHCAは、2型糖尿病における網膜および骨髄の機能障害を修正する

Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes.
  • Cristiano P Vieira
  • Seth D Fortmann
  • Masroor Hossain
  • Ana Leda Longhini
  • Sandra S Hammer
  • Bright Asare-Bediako
  • David K Crossman
  • Micheli S Sielski
  • Yvonne Adu-Agyeiwaah
  • Mariana Dupont
  • Jason L Floyd
  • Sergio Li Calzi
  • Todd Lydic
  • Robert S Welner
  • Gary J Blanchard
  • Julia V Busik
  • Maria B Grant
  • JCI Insight.2020 Jul;5(13). 137230. doi: 10.1172/jci.insight.137230.Epub 2020-07-09.

BPin前駆体のCuフッ素化による高モル活性F6-フルオロ-L-DOPAの合成(英文

Synthesis of high-molar-activity [F]6-fluoro-L-DOPA suitable for human use via Cu-mediated fluorination of a BPin precursor.
  • Andrew V Mossine
  • Sean S Tanzey
  • Allen F Brooks
  • Katarina J Makaravage
  • Naoko Ichiishi
  • Jason M Miller
  • Bradford D Henderson
  • Thomas Erhard
  • Christian Bruetting
  • Marc B Skaddan
  • Melanie S Sanford
  • Peter J H Scott
  • Nat Protoc.2020 05;15(5):1742-1759. 10.1038/s41596-020-0305-9. doi: 10.1038/s41596-020-0305-9.Epub 2020-04-08.

ジクロフェナクナトリウム関節内ゼラチン微小球製剤開発のための品質リスクマネジメントと品質バイデザイン

Quality Risk Management and Quality by Design for the Development of Diclofenac Sodium Intra-articular Gelatin Microspheres.
  • Alexandros Nakas
  • Athanasia M Dalatsi
  • Afroditi Kapourani
  • Konstantinos N Kontogiannopoulos
  • Andreana N Assimopoulou
  • Panagiotis Barmpalexis
  • AAPS PharmSciTech.2020 May;21(4):127. 10.1208/s12249-020-01678-0. doi: 10.1208/s12249-020-01678-0.Epub 2020-05-10.

2 段階の MACE プロセスにおける金属触媒の形状とエッチング液の組成を制御したシリコンナノワイヤの微細構造の工学。成長メカニズムの詳細な解析

Engineering the Microstructure of Silicon Nanowires by Controlling the Shape of the Metal Catalyst and Composition of the Etchant in a Two-step MACE Process: An In-depth Analysis of the Growth Mechanism.
  • T K Adhila
  • Hemaprabha Elangovan
  • Siju John
  • Kamanio Chattopdhyay
  • Harish Chandra Barshilia
  • Langmuir.2020 Jul;doi: 10.1021/acs.langmuir.0c01164.Epub 2020-07-20.

FGF19シグナル伝達活性化Srcによる肝ファルネソイドX受容体のリン酸化は、コレステロール値を維持し、動脈硬化から保護する

Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis.
  • Sangwon Byun
  • Hyunkyung Jung
  • Jinjing Chen
  • Young-Chae Kim
  • Dong-Hyun Kim
  • Bo Kong
  • Grace Guo
  • Byron Kemper
  • Jongsook Kim Kemper
  • J. Biol. Chem..2019 05;294(22):8732-8744. RA119.008360. doi: 10.1074/jbc.RA119.008360.Epub 2019-04-17.

培養におけるヒト大腸組織の分化。カルシウムが経上皮電気抵抗および組織凝集特性に及ぼす影響

Differentiation of human colon tissue in culture: Effects of calcium on trans-epithelial electrical resistance and tissue cohesive properties.
  • Shannon D McClintock
  • Durga Attili
  • Michael K Dame
  • Aliah Richter
  • Sabrina S Silvestri
  • Maliha M Berner
  • Margaret S Bohm
  • Kateryna Karpoff
  • Caroline L McCarthy
  • Jason R Spence
  • James Varani
  • Muhammad N Aslam
  • PLoS ONE.2020;15(3):e0222058. PONE-D-19-23237. doi: 10.1371/journal.pone.0222058.Epub 2020-03-05.

microRNA-195は心筋破綻時の代謝を制御しており、Sirtuin3の発現変化とミトコンドリアのタンパク質アセチル化を介している

MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation.
  • Xiaokan Zhang
  • Ruiping Ji
  • Xianghai Liao
  • Estibaliz Castillero
  • Peter J Kennel
  • Danielle L Brunjes
  • Marcus Franz
  • Sven Möbius-Winkler
  • Konstantinos Drosatos
  • Isaac George
  • Emily I Chen
  • Paolo C Colombo
  • P Christian Schulze
  • Circulation.2018 05;137(19):2052-2067. CIRCULATIONAHA.117.030486. doi: 10.1161/CIRCULATIONAHA.117.030486.Epub 2018-01-12.

全脳症型クロイツフェルト・ヤコブ病患者における白質変性の病因に関する免疫組織化学的および超構造学的証拠。奇妙なアストロサイトにおける誘導性一酸化窒素合成酵素の過剰発現

Immunohistochemical and ultrastructural evidence for the pathogenesis of white matter degeneration in patients with panencephalopathic-type Creutzfeldt-Jakob disease: Inducible nitric oxide synthase overexpression in bizarre astrocytes.
  • Hiroshi Kohama
  • Masahiro Kusunoki-Ii
  • Kiyota Kato
  • Masako Kato
  • Shinsuke Kato
  • Neuropathology.2020 Apr;doi: 10.1111/neup.12646.Epub 2020-04-01.