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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

コルチコトロピン放出因子受容体のホルモン認識と活性化の分子基盤

Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.
  • Shanshan Ma
  • Qingya Shen
  • Li-Hua Zhao
  • Chunyou Mao
  • X Edward Zhou
  • Dan-Dan Shen
  • Parker W de Waal
  • Peng Bi
  • Chuntao Li
  • Yi Jiang
  • Ming-Wei Wang
  • Patrick M Sexton
  • Denise Wootten
  • Karsten Melcher
  • Yan Zhang
  • H Eric Xu
  • Mol. Cell.2020 02;77(3):669-680.e4. S1097-2765(20)30013-7. doi: 10.1016/j.molcel.2020.01.013.Epub 2020-01-30.

土壌蓄積係数とDTPA抽出を用いた汚染土壌におけるCu, Cd, Pb, Znのバイオアベイラビリティーに対するミミズ活性の評価

Assessment of earthworm activity on Cu, Cd, Pb and Zn bioavailability in contaminated soils using biota to soil accumulation factor and DTPA extraction.
  • Ling Xiao
  • Ming-Hui Li
  • Jun Dai
  • Mikael Motelica-Heino
  • Xu-Fei Chen
  • Jia-Long Wu
  • Lanfeng Zhao
  • Kexue Liu
  • Chi Zhang
  • Ecotoxicol. Environ. Saf..2020 Jun;195:110513. S0147-6513(20)30352-3. doi: 10.1016/j.ecoenv.2020.110513.Epub 2020-03-23.

ニホンウズラ(Coturnix japonica)におけるアドレノメデュリンの食欲不振作用には、視床下部の弧状核におけるプロピオメラノコルチンとコカインおよびアンフェタミン調節されたトランスクリプトmRNAの増加が関与しています

The anorexigenic effect of adrenomedullin in Japanese quail (Coturnix japonica) involves increased proopiomelanocortin and cocaine- and amphetamine-regulated transcript mRNAs in the arcuate nucleus of the hypothalamus.
  • J Wang
  • A Webster
  • W Sims
  • E R Gilbert
  • M A Cline
  • Domest. Anim. Endocrinol..2020 Mar;74:106465. S0739-7240(20)30032-1. doi: 10.1016/j.domaniend.2020.106465.Epub 2020-03-02.

GNAQ および GNA11 変異型非ぶどう膜黒色腫:皮膚黒色腫とぶどう膜黒色腫の両方とは異なるサブタイプ

GNAQ and GNA11 mutant nonuveal melanoma: a subtype distinct from both cutaneous and uveal melanoma.
  • E Livingstone
  • A Zaremba
  • S Horn
  • S Ugurel
  • B Casalini
  • M Schlaak
  • J C Hassel
  • R Herbst
  • J S Utikal
  • B Weide
  • R Gutzmer
  • F Meier
  • C Koelsche
  • E Hadaschik
  • A Sucker
  • H Reis
  • S Merkelbach-Bruse
  • M Siewert
  • F Sahm
  • A von Deimling
  • I Cosgarea
  • L Zimmer
  • D Schadendorf
  • B Schilling
  • K G Griewank
  • Br. J. Dermatol..2020 Feb;doi: 10.1111/bjd.18947.Epub 2020-02-16.

フタル酸ジ(2-エチルヘキシル)は、視床下部-下垂体-卵巣軸の障害を介してウズラの卵巣の発達異常を誘発した

Di-(2-ethylhexyl) phthalate induced developmental abnormalities of the ovary in quail (Coturnix japonica) via disruption of the hypothalamic-pituitary-ovarian axis.
  • Xue-Nan Li
  • Hui-Xin Li
  • Tian-Ning Yang
  • Xiao-Wei Li
  • Yue-Qiang Huang
  • Shi-Yong Zhu
  • Jin-Long Li
  • Sci. Total Environ..2020 Jun;741:140293. S0048-9697(20)33814-6. doi: 10.1016/j.scitotenv.2020.140293.Epub 2020-06-18.

ロイコトリエン受容体拮抗薬は、ADAMsを阻害し、MICAの脱落を抑制することで、HCCの治療効果を高める

Leukotriene receptor antagonists enhance HCC treatment efficacy by inhibiting ADAMs and suppressing MICA shedding.
  • Jun Arai
  • Kaku Goto
  • Yumi Otoyama
  • Yoko Nakajima
  • Ikuya Sugiura
  • Atsushi Kajiwara
  • Masayuki Tojo
  • Yuki Ichikawa
  • Shojiro Uozumi
  • Yuu Shimozuma
  • Manabu Uchikoshi
  • Masashi Sakaki
  • Hisako Nozawa
  • Ryo Nakagawa
  • Ryosuke Muroyama
  • Naoya Kato
  • Hitoshi Yoshida
  • Cancer Immunol. Immunother..2020 Jul;10.1007/s00262-020-02660-2. doi: 10.1007/s00262-020-02660-2.Epub 2020-07-18.

ポドサイト特異的な尿細管硬化複合体2の欠失は、局所的な細分化糸球体硬化症と進行性腎不全を促進する

Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure.
  • Wakiko Iwata
  • Hiroyuki Unoki-Kubota
  • Hideki Kato
  • Akira Shimizu
  • Michihiro Matsumoto
  • Toshiyuki Imasawa
  • Arisa Igarashi
  • Kenji Matsumoto
  • Tetsuo Noda
  • Yasuo Terauchi
  • Masaomi Nangaku
  • Masato Kasuga
  • Yasushi Kaburagi
  • PLoS ONE.2020;15(3):e0229397. PONE-D-19-22136. doi: 10.1371/journal.pone.0229397.Epub 2020-03-19.

キトサン-PLGA ナノ粒子の特性を調節して、鼻から脳へのルートを意図した神経膠芽腫治療のための共同デリバリープラットフォームを設計する

Modulating chitosan-PLGA nanoparticle properties to design a co-delivery platform for glioblastoma therapy intended for nose-to-brain route.
  • Natália N Ferreira
  • Sara Granja
  • Fernanda I Boni
  • Fabíola G Prezotti
  • Leonardo M B Ferreira
  • Beatriz S F Cury
  • Rui M Reis
  • Fátima Baltazar
  • Maria Palmira D Gremião
  • Drug Deliv Transl Res.2020 Jul;10.1007/s13346-020-00824-2. doi: 10.1007/s13346-020-00824-2.Epub 2020-07-18.

分解性ホモ対マルチブロックコポリマーとその(ミクロ)構造を確立された生体材料と比較したin vivo生体適合性の研究

In vivo biocompatibility study of degradable homo- versus multiblock copolymers and their (micro)structure compared to an established biomaterial.
  • Tobias Haase
  • Robert Klopfleisch
  • Annalena Krost
  • Tilman Sauter
  • Karl Kratz
  • Jan Peter
  • Friedrich Jung
  • Andreas Lendlein
  • Dietlind Zohlnhöfer
  • Constantin Rüder
  • Clin. Hemorheol. Microcirc..2020 Jan;CH190748. doi: 10.3233/CH-190748.Epub 2020-01-04.

酸性スフィンゴミエリン酵素欠乏症における生化学的および画像化パラメータ。バイオマーカーとしての潜在的有用性

Biochemical and imaging parameters in acid sphingomyelinase deficiency: Potential utility as biomarkers.
  • Eline C B Eskes
  • Barbara Sjouke
  • Frédéric M Vaz
  • Susan M I Goorden
  • André B P van Kuilenburg
  • Johannes M F G Aerts
  • Carla E M Hollak
  • Mol. Genet. Metab..2020 05;130(1):16-26. S1096-7192(20)30052-4. doi: 10.1016/j.ymgme.2020.02.002.Epub 2020-02-12.

胃癌のイメージングおよび血管新生治療のためのTGM2を標的とした新規二重機能プローブとしてGX1ダイマーを再標識しました

Re-labeled GX1 dimer as a novel dual-functional probe targeting TGM2 for imaging and antiangiogenic therapy of gastric cancer.
  • Jipeng Yin
  • Bo Xin
  • Xiaoli Hui
  • Na Chai
  • Liping Yao
  • Hao Hu
  • Bing Xu
  • Wenhui Ma
  • Mingru Zhang
  • Jing Wang
  • Yongzhan Nie
  • Guangqing Zhou
  • Guanliang Wang
  • Liusheng Chen
  • Hongbing Lu
  • Kaichun Wu
  • Eur J Pharm Biopharm.2020 Jul;S0939-6411(20)30218-6. doi: 10.1016/j.ejpb.2020.07.015.Epub 2020-07-16.

MANα1-2MAN装飾リポソームは、BoHV-1に対するDNAワクチンで誘導される免疫原性を向上させる

MANα1-2MAN decorated liposomes enhance the immunogenicity induced by a DNA vaccine against BoHV-1.
  • Claudia Alejandra Kornuta
  • Juan Esteban Bidart
  • Ivana Soria
  • Mariela Gammella
  • Valeria Quattrocchi
  • Juan Sebastián Pappalardo
  • Stefano Salmaso
  • Vladimir Petrovich Torchilin
  • Felipe Cheuquepán Valenzuela
  • Yanina Hecker
  • Dadin Prando Moore
  • Patricia Inés Zamorano
  • Cecilia Ana Langellotti
  • Transbound Emerg Dis.2020 Jul;doi: 10.1111/tbed.13718.Epub 2020-07-09.

品質を高く保つ:マラリア迅速診断検査の品質管理におけるロット検査の利点

Keep the quality high: the benefits of lot testing for the quality control of malaria rapid diagnostic tests.
  • Sandra Incardona
  • David Bell
  • Ana Campillo
  • Jane Cunningham
  • Frederic Ariey
  • Thierry Fandeur
  • Jennifer Luchavez
  • Christian Anthony Luna
  • Didier Ménard
  • Sina Nhem
  • Johanna Beulah Sornillo
  • Benoit Witkowski
  • Zachary Katz
  • Sabine Dittrich
  • Xavier C Ding
  • Malar. J..2020 Jul;19(1):247. 10.1186/s12936-020-03324-3. doi: 10.1186/s12936-020-03324-3.Epub 2020-07-13.

新規ナトリウム利尿ペプチド受容体/グアニルシクラーゼA選択的アゴニストは、ヒト糸球体黄体細胞株におけるアンジオテンシンIIおよびフォルスコリン誘発アルドステロン合成を阻害する

Novel natriuretic peptide receptor/guanylyl cyclase A-selective agonist inhibits angiotensin II- and forskolin-evoked aldosterone synthesis in a human zona glomerulosa cell line.
  • L J Olson
  • D G Lowe
  • J G Drewett
  • Mol. Pharmacol..1996 Aug;50(2):430-5.

植物ホルモンタンパク質ネットワークによる広範なシグナル統合

Extensive signal integration by the phytohormone protein network.
  • Melina Altmann
  • Stefan Altmann
  • Patricia A Rodriguez
  • Benjamin Weller
  • Lena Elorduy Vergara
  • Julius Palme
  • Nora Marín-de la Rosa
  • Mayra Sauer
  • Marion Wenig
  • José Antonio Villaécija-Aguilar
  • Jennifer Sales
  • Chung-Wen Lin
  • Ramakrishnan Pandiarajan
  • Veronika Young
  • Alexandra Strobel
  • Lisa Gross
  • Samy Carbonnel
  • Karl G Kugler
  • Antoni Garcia-Molina
  • George W Bassel
  • Claudia Falter
  • Klaus F X Mayer
  • Caroline Gutjahr
  • A Corina Vlot
  • Erwin Grill
  • Pascal Falter-Braun
  • Nature.2020 07;583(7815):271-276. 10.1038/s41586-020-2460-0. doi: 10.1038/s41586-020-2460-0.Epub 2020-07-01.

マクロファージ遊走阻害因子の阻害は、急性膵炎の妊娠ラットにおける甲状腺機能障害を予防する

Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis.
  • Ying Chen
  • Chen-Yang Wang
  • Liang Zhao
  • Yu-Pu Hong
  • Xiao-Yi Zhang
  • Fang-Chao Mei
  • Yu Zhou
  • Wen-Yi Guo
  • Qiao Shi
  • Kai-Liang Zhao
  • Chen Chen
  • Jia Yu
  • Wei-Xing Wang
  • Int. Immunopharmacol..2020 Jul;87:106771. S1567-5769(19)33038-3. doi: 10.1016/j.intimp.2020.106771.Epub 2020-07-16.

ポリダチンによる SIRT1 活性化は、実験的糖尿病性神経障害における酸化的損傷を緩和し、ミトコンドリアの生合成を促進する

SIRT1 Activation by Polydatin Alleviates Oxidative Damage and Elevates Mitochondrial Biogenesis in Experimental Diabetic Neuropathy.
  • Preethi Bheereddy
  • Veera Ganesh Yerra
  • Anil Kumar Kalvala
  • Bhoomika Sherkhane
  • Ashutosh Kumar
  • Cell. Mol. Neurobiol..2020 Jul;10.1007/s10571-020-00923-1. doi: 10.1007/s10571-020-00923-1.Epub 2020-07-18.

水銀をナノモルレベルで選択的に検出・定量するためのAg-セルロースナノコンポジットの調製と光触媒性能の評価

Preparation of Ag-cellulose nanocomposite for the selective detection and quantification of mercury at nanomolar level and the evaluation of its photocatalytic performance.
  • S Balasurya
  • Asad Syed
  • Ajith M Thomas
  • Ali H Bahkali
  • Sarah Al-Rashed
  • Abdallah M Elgorban
  • Lija L Raju
  • Aurnava Das
  • S Sudheer Khan
  • Int. J. Biol. Macromol..2020 Jul;S0141-8130(20)33874-5. doi: 10.1016/j.ijbiomac.2020.07.119.Epub 2020-07-16.

ラットの前頭前野前庭皮質におけるFos発現ニューロンアンサンブルはコカイン探索をコードしているが、ラットでは食物探索をコードしていない

Fos-expressing neuronal ensemble in rat ventromedial prefrontal cortex encodes cocaine seeking but not food seeking in rats.
  • Louisa Kane
  • Marco Venniro
  • Richard Quintana-Feliciano
  • Rajtarun Madangopal
  • F Javier Rubio
  • Jennifer M Bossert
  • Daniele Caprioli
  • Yavin Shaham
  • Bruce T Hope
  • Brandon L Warren
  • Addict Biol.2020 Jul;:e12943. doi: 10.1111/adb.12943.Epub 2020-07-19.

腎カルシウムおよびリン酸塩処理におけるアンドロゲンの作用。ビスフォスフォネート治療と低カルシウム食の効果

Androgen action on renal calcium and phosphate handling: Effects of bisphosphonate treatment and low calcium diet.
  • Rougin Khalil
  • Ioannis Simitsidellis
  • Na Ri Kim
  • Ferran Jardi
  • Dieter Schollaert
  • Ludo Deboel
  • Philippa Saunders
  • Geert Carmeliet
  • Frank Claessens
  • Dirk Vanderschueren
  • Brigitte Decallonne
  • Mol. Cell. Endocrinol..2020 Jun;514:110891. S0303-7207(20)30191-X. doi: 10.1016/j.mce.2020.110891.Epub 2020-06-10.

大気汚染と気候が都市の樹木の成長に果たす役割

The role of air pollution and climate on the growth of urban trees.
  • Giuliano Maselli Locosselli
  • Evelyn Pereira de Camargo
  • Tiana Carla Lopes Moreira
  • Enzo Todesco
  • Maria de Fátima Andrade
  • Carmen Diva Saldiva de André
  • Paulo Afonso de André
  • Julio M Singer
  • Luciana Schwandner Ferreira
  • Paulo Hilário Nascimento Saldiva
  • Marcos Silveira Buckeridge
  • Sci. Total Environ..2019 May;666:652-661. S0048-9697(19)30789-2. doi: 10.1016/j.scitotenv.2019.02.291.Epub 2019-02-19.

エンロフロキサシン投与前後のヤギ持続性乳房炎から分離された黄色ブドウ球菌のプロファイル

Profiles of Staphyloccocus aureus isolated from goat persistent mastitis before and after treatment with enrofloxacin.
  • Magna Coroa Lima
  • Mariana de Barros
  • Thalita Moreira Scatamburlo
  • Richard Costa Polveiro
  • Laís Karolyne de Castro
  • Samuel Henrique Sales Guimarães
  • Sanely Lourenço da Costa
  • Mateus Matiuzzi da Costa
  • Maria Aparecida Scatamburlo Moreira
  • BMC Microbiol..2020 May;20(1):127. 10.1186/s12866-020-01793-9. doi: 10.1186/s12866-020-01793-9.Epub 2020-05-24.

炎症性腸疾患患者における腸外症状。ENEIDA登録に基づく研究

Extraintestinal Manifestations in Patients with Inflammatory Bowel Disease: Study Based on the ENEIDA Registry.
  • Alicia Algaba
  • Iván Guerra
  • Elena Ricart
  • Eva Iglesias
  • Miriam Mañosa
  • Javier P Gisbert
  • Jordi Guardiola
  • Miguel Mínguez
  • Beatriz Castro
  • Ruth de Francisco
  • Pilar Nos
  • Federico Bertoletti
  • Francisco Mesonero
  • Jesús Barrio
  • María Dolores Martín-Arranz
  • Xavier Calvet
  • Santiago García-López
  • Beatriz Sicilia
  • Gillermo Alcaín
  • María Esteve
  • Lucía Márquez
  • Marta Piqueras
  • Laura Jiménez
  • José L Perez-Calle
  • Luis Bujanda
  • Mariana García-Sepulcre
  • Alejandra Fernández
  • Irene Moraleja
  • Rufo Humberto Lorente
  • Orlando García-Bosch
  • Ana Lambán
  • Isabel Blázquez
  • Esther Rodríguez
  • José M Huguet
  • Alfredo J Lucendo
  • Pedro Almela
  • David Busquets
  • Patricia Ramírez de la Piscina
  • Marcela Pérez
  • Eugeni Domenech
  • Fernando Bermejo
  • Dig. Dis. Sci..2020 Jul;10.1007/s10620-020-06424-x. doi: 10.1007/s10620-020-06424-x.Epub 2020-07-15.

顎関節人工関節の同心1本針穿刺術と従来の2本針穿刺術の比較研究とコルチコステロイド注射を併用した顎関節人工関節の研究

A Comparative Study Between Concentric Single-Needle Puncture Technique and Conventional 2-Needle Technique for Temporomandibular Joint Arthrocentesis Plus Corticosteroid Injections.
  • Amit Kumar
  • Amit Gupta
  • Rajarshi Ghosh
  • Rajeev Pandey
  • Sanjeev Kumar
  • Craniomaxillofac Trauma Reconstr.2020 Jun;13(2):99-104. 10.1177_1943387520911826. doi: 10.1177/1943387520911826.Epub 2020-03-17.

中国の地域保健センターにおけるスクリーニングによって明らかになった心房細動の検出率と治療ギャップ(AF-CATCH)。プロスペクティブな多施設共同研究

Detection rate and treatment gap for atrial fibrillation identified through screening in community health centers in China (AF-CATCH): A prospective multicenter study.
  • Yi Chen
  • Qi-Fang Huang
  • Chang-Sheng Sheng
  • Wei Zhang
  • Shuai Shao
  • Dian Wang
  • Yi-Bang Cheng
  • Ying Wang
  • Qian-Hui Guo
  • Dong-Yan Zhang
  • Yan Li
  • Nicole Lowres
  • Ben Freedman
  • Ji-Guang Wang
  • PLoS Med..2020 Jul;17(7):e1003146. PMEDICINE-D-19-04467. doi: 10.1371/journal.pmed.1003146.Epub 2020-07-16.

酸素によるヘモグロビンS繊維形成のアロステリック制御と鎌状赤血球病の病態との関係

Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.
  • Eric R Henry
  • Troy Cellmer
  • Emily B Dunkelberger
  • Belhu Metaferia
  • James Hofrichter
  • Quan Li
  • David Ostrowski
  • Rodolfo Ghirlando
  • John M Louis
  • Stéphane Moutereau
  • Frédéric Galactéros
  • Swee Lay Thein
  • Pablo Bartolucci
  • William A Eaton
  • Proc. Natl. Acad. Sci. U.S.A..2020 Jun;117(26):15018-15027. 1922004117. doi: 10.1073/pnas.1922004117.Epub 2020-06-11.

一過性中大脳動脈閉塞ラットモデルにおけるフルオキセチンのHIF-1α-Netrin/VEGFカスケード、血管新生および神経保護への影響

Effect of fluoxetine on HIF-1α- Netrin/VEGF cascade, angiogenesis and neuroprotection in a rat model of transient middle cerebral artery occlusion.
  • Qimin Hu
  • Lan Liu
  • Li Zhou
  • Haiyan Lu
  • Jiayi Wang
  • Xiangyan Chen
  • Qiaoshu Wang
  • Exp. Neurol..2020 Jul;329:113312. S0014-4886(20)30143-6. doi: 10.1016/j.expneurol.2020.113312.Epub 2020-04-12.

拡張スペクトラムβ-ラクタマーゼ(ESBL)/カルバペナマーゼ産生グラム陰性菌のプランクトン細胞およびバイオフィルム細胞に対する精油のin vitro活性

In Vitro Activity of Essential Oils Against Planktonic and Biofilm Cells of Extended-Spectrum β-Lactamase (ESBL)/Carbapenamase-Producing Gram-Negative Bacteria Involved in Human Nosocomial Infections.
  • Ramona Iseppi
  • Alessandro Di Cerbo
  • Piero Aloisi
  • Mattia Manelli
  • Veronica Pellesi
  • Cinzia Provenzano
  • Stefania Camellini
  • Patrizia Messi
  • Carla Sabia
  • Antibiotics (Basel).2020 May;9(5). E272. doi: 10.3390/antibiotics9050272.Epub 2020-05-25.

片側鼠径ヘルニア修復予定患者における対側鼡径部管理のための手術戦略。国際的なWebベースのSurveymonkeyアンケート。鼠径ヘルニア修復中の対側鼡径部管理の戦略

Surgical Strategy for Contralateral Groin Management in Patients Scheduled for Unilateral Inguinal Hernia Repair: An International Web-Based Surveymonkey Questionnaire: Strategy for Contralateral Groin Management during Inguinal Hernia Repair.
  • N Johansen
  • M Miserez
  • A de Beaux
  • A Montgomery
  • J Macario Faylona
  • A Carbonell
  • T Bisgaard
  • Scand J Surg.2020 Jul;:1457496920938600. doi: 10.1177/1457496920938600.Epub 2020-07-08.

ニコチン誘発性副腎β-アレスチン1のアップレギュレーションは、タバコに関連した高アルドステロン症を媒介して心機能障害を引き起こす

Nicotine-induced adrenal beta-arrestin1 upregulation mediates tobacco-related hyperaldosteronism leading to cardiac dysfunction.
  • Natalie Cora
  • Jennifer Ghandour
  • Celina Marie Pollard
  • Victoria Lynn Desimine
  • Krysten Elaine Ferraino
  • Janelle Marie Pereyra
  • Rachel Valiente
  • Anastasios Lymperopoulos
  • World J Cardiol.2020 May;12(5):192-202. doi: 10.4330/wjc.v12.i5.192.

インド・チェンナイの都市部における移民建設労働者の間でのたばこ予防・禁煙支援サービスへのアクセスにおける社会的決定要因

Social determinants in access to tobacco prevention and cessation support services among migrant construction workers in Urban Chennai, India.
  • Sree Sucharitha Tirukkovalluri
  • Balaji Arumugam
  • N Gunasekharan
  • E Suganya
  • T Akhshaya Ponsuba
  • Divyadharshini S
  • J Family Med Prim Care.2020 Apr;9(4):1991-1998. JFMPC-9-1991. doi: 10.4103/jfmpc.jfmpc_1072_19.Epub 2020-04-30.

緑内障治療におけるジェネリックと先発品のプロスタグランジンアナログの評価。システマティックレビューとメタアナリシス

Evaluation of Generic versus Original Prostaglandin Analogues in the Treatment of Glaucoma: A Systematic Review and Meta-Analysis.
  • Alvilda T Steensberg
  • Olivia O Müllertz
  • Gianni Virgili
  • Augusto Azuara-Blanco
  • Miriam Kolko
  • Ophthalmol Glaucoma.2020 Jan - Feb;3(1):51-59. S2589-4196(19)30303-5. doi: 10.1016/j.ogla.2019.10.002.Epub 2019-11-02.

発酵黒大麦は、マウスの腸内マイクロバイオームを制御し、抗酸化活性を介して食用油煙による肺障害を改善します

Fermented black barley ameliorates lung injury induced by cooking oil fumes via antioxidant activity and regulation of the intestinal microbiome in mice.
  • Xinwen Ding
  • Li Yang
  • Qi Guan
  • Hui Zeng
  • Chenwei Song
  • Jiayi Wu
  • Lihua Song
  • Ecotoxicol. Environ. Saf..2020 Jun;195:110473. S0147-6513(20)30312-2. doi: 10.1016/j.ecoenv.2020.110473.Epub 2020-03-18.

臨床的に遺伝的変異を解釈するためのホモロジーモデリングを利用した統合的な機械学習アプローチの使用。CACNA1Fを例に挙げる

Using an integrative machine learning approach utilising homology modelling to clinically interpret genetic variants: CACNA1F as an exemplar.
  • Shalaw R Sallah
  • Panagiotis I Sergouniotis
  • Stephanie Barton
  • Simon Ramsden
  • Rachel L Taylor
  • Amro Safadi
  • Mitra Kabir
  • Jamie M Ellingford
  • Nick Lench
  • Simon C Lovell
  • Graeme C M Black
  • Eur. J. Hum. Genet..2020 Apr;10.1038/s41431-020-0623-y. doi: 10.1038/s41431-020-0623-y.Epub 2020-04-20.

スターガルト病における動的固定試験中の固定安定性に対する注意力の影響

The Effect of Attention on Fixation Stability during Dynamic Fixation Testing in Stargardt Disease.
  • Etienne M Schönbach
  • Rupert W Strauss
  • Mohamed I Ahmed
  • Jessica L Janes
  • Artur V Cideciyan
  • David G Birch
  • Janet S Sunness
  • Eberhart Zrenner
  • Michael S Ip
  • Xiangrong Kong
  • SriniVas R Sadda
  • Hendrik P N Scholl
  • Am. J. Ophthalmol..2020 May;S0002-9394(20)30230-0. doi: 10.1016/j.ajo.2020.05.002.Epub 2020-05-10.

食事性果糖は微生物由来のアセテートを介して肝臓のリポジェネシスを養う

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate.
  • Steven Zhao
  • Cholsoon Jang
  • Joyce Liu
  • Kahealani Uehara
  • Michael Gilbert
  • Luke Izzo
  • Xianfeng Zeng
  • Sophie Trefely
  • Sully Fernandez
  • Alessandro Carrer
  • Katelyn D Miller
  • Zachary T Schug
  • Nathaniel W Snyder
  • Terence P Gade
  • Paul M Titchenell
  • Joshua D Rabinowitz
  • Kathryn E Wellen
  • Nature.2020 03;579(7800):586-591. 10.1038/s41586-020-2101-7. doi: 10.1038/s41586-020-2101-7.Epub 2020-03-18.

Re.Shen etal.未治療眼における常染色体劣性スターガルト病の自然史:研究と個人レベルのデータのシステマティックレビューとメタアナリシス(Ophthalmology.2019;126:1288-1296)

Re: Shen et al.: Natural history of autosomal recessive Stargardt disease in untreated eyes: a systematic review and meta-analysis of study and individual level data (Ophthalmology. 2019;126:1288-1296).
  • Xiangrong Kong
  • Rupert W Strauss
  • Beatriz Munoz
  • Sheila West
  • Janet Cheetham
  • Hendrik P N Scholl
  • Ophthalmology.2020 May;127(5):e28-e29. S0161-6420(20)30087-7. doi: 10.1016/j.ophtha.2020.01.044.

肝細胞癌後のC型肝炎患者に対する直接作用型抗ウイルス治療の臨床成績はインターフェロン治療と同等である

Clinical outcomes of direct-acting antiviral treatments for hepatitis C patients after hepatocellular carcinoma are equivalent to interferon treatment.
  • Yuki Tahata
  • Ryotaro Sakamori
  • Ayako Urabe
  • Ryoko Yamada
  • Kazuyoshi Ohkawa
  • Naoki Hiramatsu
  • Hideki Hagiwara
  • Masahide Oshita
  • Yasuharu Imai
  • Takahiro Kodama
  • Hayato Hikita
  • Tomohide Tatsumi
  • Tetsuo Takehara
  • Hepatol. Res..2020 Jul;doi: 10.1111/hepr.13547.Epub 2020-07-17.

超変異型実験グリオーマにおける免疫チェックポイント遮断に対する反応の不均一性

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas.
  • Katrin Aslan
  • Verena Turco
  • Jens Blobner
  • Jana K Sonner
  • Anna Rita Liuzzi
  • Nicolás Gonzalo Núñez
  • Donatella De Feo
  • Philipp Kickingereder
  • Manuel Fischer
  • Ed Green
  • Ahmed Sadik
  • Mirco Friedrich
  • Khwab Sanghvi
  • Michael Kilian
  • Frederik Cichon
  • Lara Wolf
  • Kristine Jähne
  • Anna von Landenberg
  • Lukas Bunse
  • Felix Sahm
  • Daniel Schrimpf
  • Jochen Meyer
  • Allen Alexander
  • Gianluca Brugnara
  • Ralph Röth
  • Kira Pfleiderer
  • Beate Niesler
  • Andreas von Deimling
  • Christiane Opitz
  • Michael O Breckwoldt
  • Sabine Heiland
  • Martin Bendszus
  • Wolfgang Wick
  • Burkhard Becher
  • Michael Platten
  • Nat Commun.2020 02;11(1):931. 10.1038/s41467-020-14642-0. doi: 10.1038/s41467-020-14642-0.Epub 2020-02-18.

circ_0001946は、miR-641/CCND1経路を制御することで、ox-LDL刺激を受けた血管平滑筋細胞の増殖を促進し、アポトーシスを抑制することが示唆された

Circ_0001946 facilitates the proliferation and represses apoptosis of ox-LDL-stimulated Vascular Smooth Muscle Cells via regulating miR-641/CCND1 pathway.
  • Xin-Yong Cai
  • Liang Shao
  • Hong-Min Zhu
  • Yu-Liang Zhan
  • Yun-Xia Wang
  • Wei-Ling Tu
  • Lang Hong
  • Shu Wang
  • Gene.2020 Jul;:144953. S0378-1119(20)30622-3. doi: 10.1016/j.gene.2020.144953.Epub 2020-07-16.

培養塩分がソイルレスシステムで商業的に生産されたSalicornia ramosissimaの栄養組成、抗酸化能および微生物の品質に及ぼす影響

Influence of cultivation salinity in the nutritional composition, antioxidant capacity and microbial quality of Salicornia ramosissima commercially produced in soilless systems.
  • Alexandre R Lima
  • Viana Castañeda-Loaiza
  • Miguel Salazar
  • Carla Nunes
  • Célia Quintas
  • Florinda Gama
  • Maribela Pestana
  • Pedro J Correia
  • Tamára Santos
  • João Varela
  • Luísa Barreira
  • Food Chem.2020 Jul;333:127525. S0308-8146(20)31387-X. doi: 10.1016/j.foodchem.2020.127525.Epub 2020-07-10.

円周方向内視鏡的粘膜下層剥離後の食道狭窄予防のためのポリグリコール酸移植と一時的なステント留置による食道粘膜の自己組織化

Autologous esophageal mucosa with polyglycolic acid transplantation and temporary stent implantation for the prevention of esophageal stenosis after circumferential endoscopic submucosal dissection.
  • Yong Liu
  • Zhengqi Li
  • Lizhou Dou
  • Yueming Zhang
  • Guiqi Wang
  • VideoGIE.2020 Jun;5(6):230-232. S2468-4481(20)30032-1. doi: 10.1016/j.vgie.2020.02.004.Epub 2020-03-20.

脂肪組織の成長を促進するための3Dプリント可能な生体吸収性組織工学チャンバーの設計の根拠

Rationale for the design of 3D-printable bioresorbable tissue-engineering chambers to promote the growth of adipose tissue.
  • Pierre Faglin
  • Marion Gradwohl
  • César Depoortere
  • Nicolas Germain
  • Anne-Sophie Drucbert
  • Stéphanie Brun
  • Claire Nahon
  • Salim Dekiouk
  • Alexandre Rech
  • Nathalie Azaroual
  • Patrice Maboudou
  • Julien Payen
  • Pierre-Marie Danzé
  • Pierre Guerreschi
  • Philippe Marchetti
  • Sci Rep.2020 Jul;10(1):11779. 10.1038/s41598-020-68776-8. doi: 10.1038/s41598-020-68776-8.Epub 2020-07-16.

IQGAP1による足場タンパク質CBP間の相互作用は、遺伝子発現と細胞骨格活性の間のインターフェースを提供する

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.
  • Simone Kosol
  • Sara Contreras-Martos
  • Alessandro Piai
  • Mihaly Varadi
  • Tamas Lazar
  • Angela Bekesi
  • Pierre Lebrun
  • Isabella C Felli
  • Roberta Pierattelli
  • Peter Tompa
  • Sci Rep.2020 Apr;10(1):5753. 10.1038/s41598-020-62069-w. doi: 10.1038/s41598-020-62069-w.Epub 2020-04-01.

オフィオポゴニンDはストレプトゾトシン誘発糖尿病性腎症ラットの酸化ストレスと炎症反応を抑制することで腎機能を改善する

Ophiopogonin D of Ophiopogon japonicus ameliorates renal function by suppressing oxidative stress and inflammatory response in streptozotocin-induced diabetic nephropathy rats.
  • Yanhong Qiao
  • Haiyan Jiao
  • Feng Wang
  • Huimin Niu
  • Braz. J. Med. Biol. Res..2020;53(7):e9628. S0100-879X2020000700604. doi: 10.1590/1414-431X20209628.Epub 2020-06-03.

特定のgyrA遺伝子変異は,中国北京から分離されたMycobacterium tuberculosis分離株における不一致レボフロキサシン耐性の高い有病率と相関していた

Specific gyrA gene mutations correlate with high prevalence of discordant levofloxacin resistance in Mycobacterium tuberculosis isolates from Beijing, China.
  • Fengmin Huo
  • Yifeng Ma
  • Shanshan Li
  • Yi Xue
  • Yuanyuan Shang
  • Lingling Dong
  • Yunxu Li
  • Yu Pang
  • J Mol Diagn.2020 Jun;S1525-1578(20)30373-1. doi: 10.1016/j.jmoldx.2020.06.010.Epub 2020-06-30.

胃内視鏡的粘膜下層剥離後の遅発性出血のリスクに対する抗凝固薬の影響:多施設共同レトロスペクティブ研究

Influence of anticoagulants on the risk of delayed bleeding after gastric endoscopic submucosal dissection: a multicenter retrospective study.
  • Hideomi Tomida
  • Toshiyuki Yoshio
  • Kimihiro Igarashi
  • Yoshinori Morita
  • Ichiro Oda
  • Takuya Inoue
  • Takuto Hikichi
  • Tetsuya Sumiyoshi
  • Hisashi Doyama
  • Yosuke Tsuji
  • Jun Nishikawa
  • Waku Hatta
  • Tatsuya Mikami
  • Mikitaka Iguchi
  • Kazuki Sumiyama
  • Katsumi Yamamoto
  • Kazuya Kitamura
  • Shiko Kuribayashi
  • Atsushi Yanagitani
  • Toshio Uraoka
  • Tomoyuki Yada
  • Kenkei Hasatani
  • Koichiro Kawaguchi
  • Tomoki Fujita
  • Tsutomu Nishida
  • Yoichi Hiasa
  • Mitsuhiro Fujishiro
  • Gastric Cancer.2020 Jul;10.1007/s10120-020-01105-0. doi: 10.1007/s10120-020-01105-0.Epub 2020-07-18.

BPIFB4 の長寿関連バリアントは、ハンチントン病マウスモデルにおいて、CXCR4 を介した線条体-ミクログリアのクロストークを改善し、病気の進行を抑制する

The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease.
  • Alba Di Pardo
  • Elena Ciaglia
  • Monica Cattaneo
  • Anna Maciag
  • Francesco Montella
  • Valentina Lopardo
  • Anna Ferrario
  • Francesco Villa
  • Michele Madonna
  • Enrico Amico
  • Albino Carrizzo
  • Antonio Damato
  • Giuseppe Pepe
  • Federico Marracino
  • Alberto Auricchio
  • Carmine Vecchione
  • Vittorio Maglione
  • Annibale A Puca
  • Cell Death Dis.2020 Jul;11(7):546. 10.1038/s41419-020-02754-w. doi: 10.1038/s41419-020-02754-w.Epub 2020-07-18.

ヒト歯髄幹細胞を用いた異種移植モデルでの下顎骨欠損部の再構築-臨床、放射線学的、組織学的評価

Critical-sized mandibular defect reconstruction using human dental pulp stem cells in a xenograft model-clinical, radiological, and histological evaluation.
  • Juan G Gutiérrez-Quintero
  • Juan Y Durán Riveros
  • Carlos A Martínez Valbuena
  • Sofía Pedraza Alonso
  • J C Munévar
  • S M Viafara-García
  • Oral Maxillofac Surg.2020 Jul;10.1007/s10006-020-00862-7. doi: 10.1007/s10006-020-00862-7.Epub 2020-07-10.