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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

グルココルチコイドと血清およびグルココルチコイド誘導性キナーゼ1は、在来腸におけるCFTRの強力な調節因子である:ストレス誘発性下痢の意味合い

Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea.
  • Md Kaimul Ahsan
  • Leandra Figueroa-Hall
  • Vanessa Baratta
  • Rolando Garcia-Milian
  • TuKiet T Lam
  • Kazi Hoque
  • Pedro J Salas
  • Nadia A Ameen
  • Am. J. Physiol. Gastrointest. Liver Physiol..2020 Aug;319(2):G121-G132. doi: 10.1152/ajpgi.00076.2020.Epub 2020-06-22.

NCI指定がんセンター内でのたばこ止めプログラムの実施を評価するためのRE-AIMフレームワークの実用的な適用

Pragmatic Application of the RE-AIM Framework to Evaluate the Implementation of Tobacco Cessation Programs Within NCI-Designated Cancer Centers.
  • Heather D'Angelo
  • Alex T Ramsey
  • Betsy Rolland
  • Li-Shiun Chen
  • Steven L Bernstein
  • Lisa M Fucito
  • Monica Webb Hooper
  • Robert Adsit
  • Danielle Pauk
  • Marika S Rosenblum
  • Paul M Cinciripini
  • Anne Joseph
  • Jamie S Ostroff
  • Graham W Warren
  • Michael C Fiore
  • Timothy B Baker
  • Front Public Health.2020;8:221. doi: 10.3389/fpubh.2020.00221.Epub 2020-06-12.

真菌フィターゼのゲノムスケールでの特性評価、およびβ-プロペラフィターゼとヒスチジン酸ホスファターゼの比較研究

Genome-Scale Characterization of Fungal Phytases and a Comparative Study Between Beta-Propeller Phytases and Histidine Acid Phosphatases.
  • Roberta Corsino Ferreira
  • Murillo Peterlini Tavares
  • Túlio Morgan
  • Yan da Silva Clevelares
  • Marina Quádrio Raposo Branco Rodrigues
  • Maria Catarina Megumi Kasuya
  • Tiago Antônio de Oliveira Mendes
  • Valéria Monteze Guimarães
  • Appl. Biochem. Biotechnol..2020 May;10.1007/s12010-020-03309-7. doi: 10.1007/s12010-020-03309-7.Epub 2020-05-06.

ウィタフェリンAは、2孔ドメインカリウム(K2P9)チャネルTASK-3を阻害することで乳がん細胞の増殖を抑制します

Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3.
  • Rafael Zúñiga
  • Guierdy Concha
  • Angel Cayo
  • Rocio Cikutović-Molina
  • Bárbara Arevalo
  • Wendy González
  • Marcelo A Catalán
  • Leandro Zúñiga
  • Biomed. Pharmacother..2020 Jun;129:110383. S0753-3322(20)30576-X. doi: 10.1016/j.biopha.2020.110383.Epub 2020-06-17.

網膜下に注入された半導体ポリマーナノ粒子は、網膜ジストロフィーのラットモデルにおける視力を回復させる

Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy.
  • José Fernando Maya-Vetencourt
  • Giovanni Manfredi
  • Maurizio Mete
  • Elisabetta Colombo
  • Mattia Bramini
  • Stefano Di Marco
  • Dmytro Shmal
  • Giulia Mantero
  • Michele Dipalo
  • Anna Rocchi
  • Mattia L DiFrancesco
  • Ermanno D Papaleo
  • Angela Russo
  • Jonathan Barsotti
  • Cyril Eleftheriou
  • Francesca Di Maria
  • Vanessa Cossu
  • Fabio Piazza
  • Laura Emionite
  • Flavia Ticconi
  • Cecilia Marini
  • Gianmario Sambuceti
  • Grazia Pertile
  • Guglielmo Lanzani
  • Fabio Benfenati
  • Nat Nanotechnol.2020 Jun;10.1038/s41565-020-0696-3. doi: 10.1038/s41565-020-0696-3.Epub 2020-06-29.

化学療法を受けている乳がん患者における音楽介入のQOLへの影響。無作為化臨床試験

Impact of a Music Intervention on Quality of Life in Breast Cancer Patients Undergoing Chemotherapy: A Randomized Clinical Trial.
  • Talita Uchoa Lima
  • Ed Carlos Rey Moura
  • Caio Márcio Barros de Oliveira
  • Rachel Jorge Dino Cossetti Leal
  • João Nogueira Neto
  • Emanuel Cabral Pereira
  • Raniere Victor Braga Nascimento
  • Eduardo José Silva Gomes de Oliveira
  • Plínio da Cunha Leal
  • Integr Cancer Ther.2020 Jan-Dec;19:1534735420938430. doi: 10.1177/1534735420938430.

オリゴデンドロサイト前駆細胞の破壊は、アルツハイマー病のトリプルトランスジェニックマウスモデルにおける病理の初期徴候である

Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease.
  • Ilaria Vanzulli
  • Maria Papanikolaou
  • Irene Chacon De-La-Rocha
  • Francesca Pieropan
  • Andrea D Rivera
  • Diego Gomez-Nicola
  • Alexei Verkhratsky
  • José Julio Rodríguez
  • Arthur M Butt
  • Neurobiol. Aging.2020 Jun;94:130-139. S0197-4580(20)30185-8. doi: 10.1016/j.neurobiolaging.2020.05.016.Epub 2020-06-07.

ニコチンアミドN-メチルトランスフェラーゼは、代謝リプログラミングとWarburg効果の促進により、ヒト食道扁平上皮癌における5-フルオロウラシル感受性を低下させる

Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect.
  • Yanyan Cui
  • Dawei Yang
  • Wenjie Wang
  • Luyu Zhang
  • Hongtao Liu
  • Shanshan Ma
  • Wenna Guo
  • Minghao Yao
  • Kun Zhang
  • Wencai Li
  • Yanting Zhang
  • Fangxia Guan
  • Mol. Carcinog..2020 Aug;59(8):940-954. doi: 10.1002/mc.23209.Epub 2020-05-04.

精神科患者と学生のコントロールにおけるスマートフォンベースの生態学的瞬間評価(EMA)。現実世界の実現可能性研究

Smartphone-based ecological momentary assessment (EMA) in psychiatric patients and student controls: A real-world feasibility study.
  • Alejandro Porras-Segovia
  • Rosa María Molina-Madueño
  • Sofian Berrouiguet
  • Jorge López-Castroman
  • Maria Luisa Barrigón
  • María Sandra Pérez-Rodríguez
  • José Heliodoro Marco
  • Isaac Díaz-Oliván
  • Santiago de León
  • Philippe Courtet
  • Antonio Artés-Rodríguez
  • Enrique Baca-García
  • J Affect Disord.2020 Sep;274:733-741. S0165-0327(20)30440-7. doi: 10.1016/j.jad.2020.05.067.Epub 2020-05-26.

hPSC由来の肺オルガノイドを用いた候補COVID-19治療薬の同定

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids.
  • Yuling Han
  • Liuliu Yang
  • Xiaohua Duan
  • Fuyu Duan
  • Benjamin E Nilsson-Payant
  • Tomer M Yaron
  • Pengfei Wang
  • Xuming Tang
  • Tuo Zhang
  • Zeping Zhao
  • Yaron Bram
  • David Redmond
  • Sean Houghton
  • Duc Nguyen
  • Dong Xu
  • Xing Wang
  • Skyler Uhl
  • Yaoxing Huang
  • Jared L Johnson
  • Jenny Xiang
  • Hui Wang
  • Fong Cheng Pan
  • Lewis C Cantley
  • Benjamin R tenOever
  • David D Ho
  • Todd Evans
  • Robert E Schwartz
  • Huanhuan Joyce Chen
  • Shuibing Chen
  • bioRxiv.2020 May;2020.05.05.079095. doi: 10.1101/2020.05.05.079095.Epub 2020-05-05.

バイタルサイン。産後の抑うつ症状と周産期うつ病についてのプロバイダーの話し合い-米国、2018年

Vital Signs: Postpartum Depressive Symptoms and Provider Discussions About Perinatal Depression - United States, 2018.
  • Brenda L Bauman
  • Jean Y Ko
  • Shanna Cox
  • Denise V D'Angelo Mph
  • Lee Warner
  • Suzanne Folger
  • Heather D Tevendale
  • Kelsey C Coy
  • Leslie Harrison
  • Wanda D Barfield
  • MMWR Morb. Mortal. Wkly. Rep..2020 May;69(19):575-581. doi: 10.15585/mmwr.mm6919a2.Epub 2020-05-15.

低酸素状態に曝露したDcytbノックアウトマウスでは、十二指腸還元酵素活性と脾臓鉄貯蔵量が低下し、赤血球造血が異常になる

Duodenal reductase activity and spleen iron stores are reduced and erythropoiesis is abnormal in Dcytb knockout mice exposed to hypoxic conditions.
  • Jeehyea Choi
  • Patarabutr Masaratana
  • Gladys O Latunde-Dada
  • Matthew Arno
  • Robert J Simpson
  • Andrew T McKie
  • J. Nutr..2012 Nov;142(11):1929-34. jn.112.160358. doi: 10.3945/jn.112.160358.Epub 2012-09-18.

UPLC-MS/MSによるヒト血漿中の重水素化ボルチオキセチンとその主要代謝物の同時定量と健康なボランティアを対象とした薬物動態試験への応用

Simultaneous determination of deuterated vortioxetine and its major metabolite in human plasma by UPLC-MS/MS and application to a pharmacokinetic study in healthy volunteers.
  • Yingyue Yi
  • Guanghui Ren
  • Ming Zheng
  • Di Zhao
  • Ning Li
  • Xijng Chen
  • Yang Lu
  • J. Chromatogr. B Analyt. Technol. Biomed. Life Sci..2020 Feb;1138:121955. S1570-0232(19)31662-9. doi: 10.1016/j.jchromb.2019.121955.Epub 2019-12-23.

入院患者における精神病性うつ病。入院患者における精神病性うつ病と非精神病性うつ病の縦断的転帰。臨床重症度における抑うつ症状の役割

Psychotic depression in hospitalized patients: Longitudinal outcomes of psychotic vs. nonpsychotic depression among inpatients: The role of depressive symptoms on clinical severity.
  • Felipe Bauer Pinto da Costa
  • Eduardo Trachtenberg
  • Aline Boni
  • Lucas Primo de Carvalho Alves
  • Pedro Vieira da Silva Magalhães
  • Neusa Sica Rocha
  • J Psychiatr Res.2020 Jun;129:73-79. S0022-3956(20)30280-6. doi: 10.1016/j.jpsychires.2020.06.002.Epub 2020-06-02.

感情障害に対するトランス診断ガイド付きインターネット配信プロトコルの有効性と、専門ケアにおける通常の治療との比較。ランダム化比較試験

Effectiveness of a Transdiagnostic Guided Internet-Delivered Protocol for Emotional Disorders Versus Treatment as Usual in Specialized Care: Randomized Controlled Trial.
  • Alberto González-Robles
  • Amanda Díaz-García
  • Azucena García-Palacios
  • Pablo Roca
  • Josep Antoni Ramos-Quiroga
  • Cristina Botella
  • J. Med. Internet Res..2020 Jul;22(7):e18220. v22i7e18220. doi: 10.2196/18220.Epub 2020-07-07.

カメルーン南西部における予防接種拡大プログラムの下での予防接種の適用範囲

Vaccination Coverage Under the Expanded Program on Immunization in South West Cameroon.
  • Bestina Forkwa Ewang
  • Mathias Esum Eyong
  • Samuel Nambile Cumber
  • Claude Ngwayu Nkfusai
  • Brenda Mbouamba Yankam
  • Cho Sabastine Anye
  • Jacintha Rebang Achu
  • Bih Moki Suh
  • Mildred Njoache Nkeng
  • Rosette Boseme Nzoyom
  • Joyce Mahlako Tsoka-Gwegweni
  • Eric Achidi Akum
  • Int J MCH AIDS.2020;9(2):242-251. IJMA-9-242. doi: 10.21106/ijma.308.Epub 2020-07-09.

構造的に拘束されたシクロプロパン含有ビルディングブロックを有する大環状ペプチドライブラリーは、ホスホグリセリン酸ムターゼのチオール非依存性阻害剤を導く

A macrocyclic peptide library with a structurally constrained cyclopropane-containing building block leads to thiol-independent inhibitors of phosphoglycerate mutase.
  • Rika Okuma
  • Tomoki Kuwahara
  • Takafumi Yoshikane
  • Mizuki Watanabe
  • Patricia Dranchak
  • James Inglese
  • Satoshi Shuto
  • Yuki Goto
  • Hiroaki Suga
  • Chem Asian J.2020 Jul;doi: 10.1002/asia.202000700.Epub 2020-07-07.

ケモカイン-ケモカイン受容体軸の応用は、大腸癌患者におけるサイトカイン誘導キラー細胞の腫瘍標的遊走能を増加させる

Application of the chemokine-chemokine receptor axis increases the tumor-targeted migration ability of cytokine-induced killer cells in patients with colorectal cancer.
  • Yunlian Zou
  • Jianhua Liang
  • Danyang Li
  • Jingjing Fang
  • Linping Wang
  • Jinli Wang
  • Jinping Zhang
  • Qiang Guo
  • Xinmin Yan
  • Hui Tang
  • Oncol Lett.2020 Jul;20(1):123-134. OL-0-0-11539. doi: 10.3892/ol.2020.11539.Epub 2020-04-15.

NSC-34細胞の分化は、NGF受容体p75、グルタミナーゼ、NCAM L1の発現、ミトコンドリアの活性化、脂肪酸の介入に対する感受性によって特徴づけられる

Differentiation of NSC-34 cells is characterized by expression of NGF receptor p75, glutaminase and NCAM L1, activation of mitochondria, and sensitivity to fatty acid intervention.
  • Gerburg Keilhoff
  • Ricardo Pirex Mbou
  • Benjamin Lucas
  • Acta Histochem..2020 Jul;122(5):151574. S0065-1281(20)30073-8. doi: 10.1016/j.acthis.2020.151574.Epub 2020-06-15.

RST1とRIPRはシロイヌナズナの細胞質RNAエクソソームとスキー複合体に接続している

RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis.
  • Heike Lange
  • Simon Y A Ndecky
  • Carlos Gomez-Diaz
  • David Pflieger
  • Nicolas Butel
  • Julie Zumsteg
  • Lauriane Kuhn
  • Christina Piermaria
  • Johana Chicher
  • Michael Christie
  • Ezgi S Karaaslan
  • Patricia L M Lang
  • Detlef Weigel
  • Hervé Vaucheret
  • Philippe Hammann
  • Dominique Gagliardi
  • Nat Commun.2019 08;10(1):3871. 10.1038/s41467-019-11807-4. doi: 10.1038/s41467-019-11807-4.Epub 2019-08-27.

腹腔内感染後の敗血症性ショックからの回復に対するフィソスチグミンの効果 - 無作為化、二重盲検、プラセボ対照、単心パイロット試験の結果(Anticholium® per Se)

Effect of physostigmine on recovery from septic shock following intra-abdominal infection - Results from a randomized, double-blind, placebo-controlled, monocentric pilot trial (Anticholium® per Se).
  • Nadine Pinder
  • Thomas Bruckner
  • Monika Lehmann
  • Johann Motsch
  • Thorsten Brenner
  • Jan Larmann
  • Phillip Knebel
  • Torsten Hoppe-Tichy
  • Stefanie Swoboda
  • Markus A Weigand
  • Stefan Hofer
  • Johannes B Zimmermann
  • J Crit Care.2019 08;52:126-135. S0883-9441(19)30098-X. doi: 10.1016/j.jcrc.2019.04.012.Epub 2019-04-09.

補完代替医療(CAM)の医師の態度と認識。多拠点イタリアの研究

Physician Attitudes and Perceptions of Complementary and Alternative Medicine (CAM): A Multicentre Italian Study.
  • Massimiliano Berretta
  • Luca Rinaldi
  • Rosaria Taibi
  • Paolo Tralongo
  • Alberto Fulvi
  • Vincenzo Montesarchio
  • Giordano Madeddu
  • Paolo Magistri
  • Sabrina Bimonte
  • Marco Trovò
  • Patrizia Gnagnarella
  • Arturo Cuomo
  • Marco Cascella
  • Arben Lleshi
  • Guglielmo Nasti
  • Sergio Facchini
  • Francesco Fiorica
  • Raffaele Di Francia
  • Giuseppe Nunnari
  • Giovanni Francesco Pellicanò
  • Aurelio Guglielmino
  • Marco Danova
  • Sabrina Rossetti
  • Alfonso Amore
  • Anna Crispo
  • Gaetano Facchini
  • Front Oncol.2020;10:594. doi: 10.3389/fonc.2020.00594.Epub 2020-04-28.

プロゲステロン受容体を選択的に阻害した骨粗鬆症細胞を持つマウスのコラーゲン誘導性関節炎に対する高い感受性

High susceptibility to collagen-induced arthritis in mice with progesterone receptors selectively inhibited in osteoprogenitor cells.
  • Lixian Liu
  • Junjing Jia
  • Min Jiang
  • Xueping Liu
  • Chenling Dai
  • Barton L Wise
  • Nancy E Lane
  • Wei Yao
  • Arthritis Res. Ther..2020 Jul;22(1):165. 10.1186/s13075-020-02242-8. doi: 10.1186/s13075-020-02242-8.Epub 2020-07-02.