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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

輸血依存性β-タラセミア重症患者でDeferasirox療法を受けた場合の尿中代謝プロファイル

Urinary Metabolic Profile of Patients with Transfusion-Dependent β-Thalassemia Major Undergoing Deferasirox Therapy.
  • Giovanna Capolongo
  • Miriam Zacchia
  • Amerigo Beneduci
  • Silvia Costantini
  • Patrizia Cinque
  • Anna Spasiano
  • Giuseppina De Luca
  • Maria Enrica Di Pietro
  • Paolo Ricchi
  • Francesco Trepiccione
  • Giovambattista Capasso
  • Aldo Filosa
  • Kidney Blood Press. Res..2020;45(3):455-466. 000507369. doi: 10.1159/000507369.Epub 2020-05-20.

プールされた単細胞遺伝学的スクリーニングは、上皮から間葉系への移行の連続体における制御的チェックポイントを同定する

A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition.
  • José L McFaline-Figueroa
  • Andrew J Hill
  • Xiaojie Qiu
  • Dana Jackson
  • Jay Shendure
  • Cole Trapnell
  • Nat. Genet..2019 09;51(9):1389-1398. 10.1038/s41588-019-0489-5. doi: 10.1038/s41588-019-0489-5.Epub 2019-09-02.

子どもの虐待に関する世界的な研究動向の書誌学的分析

A Bibliometric Analysis of the Global Research Trend in Child Maltreatment.
  • Bach Xuan Tran
  • Thang Van Pham
  • Giang Hai Ha
  • Anh Toan Ngo
  • Long Hoang Nguyen
  • Thuc Thi Minh Vu
  • Ha Ngoc Do
  • Vu Nguyen
  • Anh Tuan Le Nguyen
  • Tung Thanh Tran
  • Nu Thi Truong
  • Vuong Quan Hoang
  • Tung Manh Ho
  • Nhue Van Dam
  • Thu Trang Vuong
  • Hung Quang Nguyen
  • Huong Thi Le
  • Hoa Thi Do
  • Mackenzie Moir
  • Yoko Shimpuku
  • Meghnath Dhimal
  • Shalini Subash Arya
  • Tu Huu Nguyen
  • Suraj Bhattarai
  • Carl A Latkin
  • Cyrus S H Ho
  • Roger C M Ho
  • Int J Environ Res Public Health.2018 07;15(7). E1456. doi: 10.3390/ijerph15071456.Epub 2018-07-10.

上皮成長因子受容体(EGFR)のL858R/T790M変異を有する肺癌に対するプローブとしての放射性ヨウ素化ロシレチニブ(CO-1686)の合成と基礎的評価

Synthesis and Fundamental Evaluation of Radioiodinated Rociletinib (CO-1686) as a Probe to Lung Cancer with L858R/T790M Mutations of Epidermal Growth Factor Receptor (EGFR).
  • Muammar Fawwaz
  • Kenji Mishiro
  • Ryuichi Nishii
  • Izumi Sawazaki
  • Kazuhiro Shiba
  • Seigo Kinuya
  • Kazuma Ogawa
  • Molecules.2020 Jun;25(12). E2914. doi: 10.3390/molecules25122914.Epub 2020-06-24.

ニーマンピック病B型を引き起こすp. (Ala359Asp) SMPD1変異体の疫学的、臨床的、生化学的特徴の検討

Epidemiological, clinical and biochemical characterization of the p.(Ala359Asp) SMPD1 variant causing Niemann-Pick disease type B.
  • Mariana Acuña
  • Pablo Martínez
  • Carol Moraga
  • Xingxuan He
  • Mauricio Moraga
  • Bessie Hunter
  • Peter Nuernberg
  • Rodrigo A Gutiérrez
  • Mauricio González
  • Edward H Schuchman
  • José Luis Santos
  • Juan Francisco Miquel
  • Paulina Mabe
  • Silvana Zanlungo
  • Eur. J. Hum. Genet..2016 Feb;24(2):208-13. ejhg201589. doi: 10.1038/ejhg.2015.89.Epub 2015-04-29.

日本脳炎や西ナイルウイルス感染時のヒト神経細胞モデルプロテオームの比較と、神経病理発生における蚊の唾液の役割の可能性

Comparison of a human neuronal model proteome upon Japanese encephalitis or West Nile Virus infection and potential role of mosquito saliva in neuropathogenesis.
  • Benoit Besson
  • Justine Basset
  • Sandrine Gatellier
  • Hélène Chabrolles
  • Thibault Chaze
  • Véronique Hourdel
  • Mariette Matondo
  • Nathalie Pardigon
  • Valérie Choumet
  • PLoS ONE.2020;15(5):e0232585. PONE-D-19-22706. doi: 10.1371/journal.pone.0232585.Epub 2020-05-06.

子癇前症におけるステロイド産生とアロマターゼ活性の異常

Abnormal steroidogenesis and aromatase activity in preeclampsia.
  • Nadia Berkane
  • Philippe Liere
  • Guillaume Lefevre
  • Nadia Alfaidy
  • Roland Abi Nahed
  • Jessica Vincent
  • Jean-Paul Oudinet
  • Antoine Pianos
  • Annie Cambourg
  • Patrick Rozenberg
  • Pierre Galichon
  • Alexandra Rousseau
  • Tabassome Simon
  • Michael Schumacher
  • Nathalie Chabbert-Buffet
  • Alexandre Hertig
  • Placenta.2018 09;69:40-49. S0143-4004(18)30653-2. doi: 10.1016/j.placenta.2018.07.004.Epub 2018-07-07.

カナダ人患者の下痢便検体から分離されたClostridioides difficileの抗菌薬感受性:2013年から2017年までのCanadian Clostridioides difficile(CAN-DIFF)サーベイランス研究の結果の要約

Antimicrobial susceptibility of Clostridioides difficile isolated from diarrhoeal stool specimens of Canadian patients: summary of results from the Canadian Clostridioides difficile (CAN-DIFF) surveillance study from 2013 to 2017.
  • James A Karlowsky
  • Heather J Adam
  • Melanie R Baxter
  • Christopher W Dutka
  • Kim A Nichol
  • Nancy M Laing
  • George R Golding
  • George G Zhanel
  • J. Antimicrob. Chemother..2020 Jul;75(7):1824-1832. 5820582. doi: 10.1093/jac/dkaa118.

換気依存症の原因と診断、および離乳食の実施と請求に関する声明 - ドイツ呼吸器学会(DGP)と呼吸器科医会(VPK)が編纂

[Statement on Causes and Diagnostics of Ventilation Dependency as well as Implementation and Invoicing of the Weaning Process - Compiled by the German Respiratory Society (DGP) and the Association of Pneumological Clinics (VPK)].
  • J Geiseler
  • M Westhoff
  • D Dellweg
  • T Voshaar
  • M Hetzel
  • M Pfeifer
  • Pneumologie.2019 12;73(12):716-722. doi: 10.1055/a-1039-7143.Epub 2019-12-09.

血漿プロテオミクスにより、重度の急性栄養不良を呈する HIV 感染児の代謝ストレスのマーカーが明らかになった

Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition.
  • Gerard Bryan Gonzales
  • James M Njunge
  • Bonface M Gichuki
  • Bijun Wen
  • Isabel Potani
  • Wieger Voskuijl
  • Robert H J Bandsma
  • James A Berkley
  • Sci Rep.2020 Jul;10(1):11235. 10.1038/s41598-020-68143-7. doi: 10.1038/s41598-020-68143-7.Epub 2020-07-08.

ステロイドホルモン受容体の変異体および変異体の転写活性の定量的評価 2 つのレポーターと受容体発現カセットを持つ単一ベクターを用いたステロイドホルモン受容体の変異体および変異体の転写活性の定量的評価

Quantitative Evaluation of the Transcriptional Activity of Steroid Hormone Receptor Mutants and Variants Using a Single Vector With Two Reporters and a Receptor Expression Cassette.
  • Huimin Ji
  • Ying Li
  • Zhao Liu
  • Min Tang
  • Lihui Zou
  • Fei Su
  • Yaqun Zhang
  • Junhua Zhang
  • Hexin Li
  • Lin Li
  • Bin Ai
  • Jie Ma
  • Lunan Wang
  • Ming Liu
  • Fei Xiao
  • Front Endocrinol (Lausanne).2020;11:167. doi: 10.3389/fendo.2020.00167.Epub 2020-03-31.

モルビリウイルスPeste des Petits Ruminantsの病原性単離株と変異株を区別するマウス細胞株の同定、病原性研究のための有望なツール

Identification of a murine cell line that distinguishes virulent from attenuated isolates of the morbillivirus Peste des Petits Ruminants, a promising tool for virulence studies.
  • Juliana Comerlato
  • Emmanuel Albina
  • Carinne Puech
  • Ana C Franco
  • Cécile Minet
  • Roger-Junior Eloiflin
  • Valérie Rodrigues
  • Renata Servan de Almeida
  • Virus Res..2020 May;286:198035. S0168-1702(20)30618-3. doi: 10.1016/j.virusres.2020.198035.Epub 2020-05-24.

黒色土壌へのバイオ炭の逐次施用による微生物応答と物理化学的特性に影響を与える新規環境因子の検討

Novel environmental factors affecting microbial responses and physicochemical properties by sequentially applied biochar in black soil.
  • Huanhuan Wang
  • Shen Yan
  • Tianbao Ren
  • Ye Yuan
  • Gang Kuang
  • Bo Wang
  • Fei Yun
  • Huilin Feng
  • Xiaoming Ji
  • Xiaojing Yuan
  • Guoshun Liu
  • Environ Sci Pollut Res Int.2020 Jul;10.1007/s11356-020-10081-y. doi: 10.1007/s11356-020-10081-y.Epub 2020-07-17.

IDOの阻害は、光線力学的治療と組み合わせることで、マウスのIL-6依存性全身炎症を引き起こす

Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy.
  • Malgorzata Wachowska
  • Joanna Stachura
  • Katarzyna Tonecka
  • Klaudyna Fidyt
  • Agata Braniewska
  • Zuzanna Sas
  • Iwona Kotula
  • Tomasz Piotr Rygiel
  • Louis Boon
  • Jakub Golab
  • Angelika Muchowicz
  • Cancer Immunol. Immunother..2020 Jun;69(6):1101-1112. 10.1007/s00262-020-02528-5. doi: 10.1007/s00262-020-02528-5.Epub 2020-02-28.

都市部で自然感染したLymnaea columella(軟体動物、ガストロプダ)由来のXiphidiocercariae:幼虫の形態学的・超構造と軟体動物宿主の組織学的変化

Xiphidiocercariae from naturally infected Lymnaea columella (Mollusca, Gastropoda) in urban area: morphology and ultrastructure of the larvae and histological changes in the mollusc host.
  • E Paviotti-Fischer
  • E J Lopes-Torres
  • M A J Santos
  • S V P B Brandolini
  • J Pinheiro
  • Braz J Biol.2019 Jul-Sep;79(3):446-451. S1519-69842019000300446. doi: 10.1590/1519-6984.182501.Epub 2018-10-04.

イミノシュガーAMP-DNMはGLP1を介して満腹感を改善し、褐色脂肪組織を活性化する

The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1.
  • Daniela Herrera Moro Chao
  • Yanan Wang
  • Ewout Foppen
  • Roelof Ottenhoff
  • Cindy van Roomen
  • Edwin T Parlevliet
  • Marco van Eijk
  • Marri Verhoek
  • Rolf Boot
  • Andre R Marques
  • Saskia Scheij
  • Mina Mirzaian
  • Sander Kooijman
  • Kirstin Jansen
  • Dawei Wang
  • Clarita Mergen
  • Randy J Seeley
  • Matthias H Tschöp
  • Herman Overkleeft
  • Patrick C N Rensen
  • Andries Kalsbeek
  • Johannes M F G Aerts
  • Chun-Xia Yi
  • Diabetes.2019 12;68(12):2223-2234. db19-0049. doi: 10.2337/db19-0049.Epub 2019-10-02.

FDA承認の抗エストロゲン剤Faslodexを用いてERβ/アンジオポエチン-2/Tie-2シグナルを介した血管新生を標的とし、RCCにおけるスニチニブの感度を向上させる

Targeting the ERβ/Angiopoietin-2/Tie-2 signaling-mediated angiogenesis with the FDA-approved anti-estrogen Faslodex to increase the Sunitinib sensitivity in RCC.
  • Junfei Gu
  • Yong Zhang
  • Zhenwei Han
  • Lei Gao
  • Jinfeng Cui
  • Yin Sun
  • Yuanjie Niu
  • Bosen You
  • Chi-Ping Huang
  • Chawnshang Chang
  • Xiaolu Wang
  • Shuyuan Yeh
  • Cell Death Dis.2020 May;11(5):367. 10.1038/s41419-020-2486-0. doi: 10.1038/s41419-020-2486-0.Epub 2020-05-14.

ニコチンのピロリジニウム環のメチルスキャンにより、α7およびα4β2ニコチン性アセチルコリン受容体との相互作用に有意な差異が示された

A Methyl Scan of the Pyrrolidinium Ring of Nicotine Reveals Significant Differences in its Interactions with α7 and α4β2 Nicotinic Acetylcholine Receptors.
  • Hong Xing
  • Kristin W Andrud
  • Ferenc Soti
  • Anne Rouchaud
  • Stephan C Jahn
  • Ziang Lu
  • Yeh-Hyon Cho
  • Sophia Habibi
  • Patrick Corsino
  • Svetoslav Slavov
  • James R Rocca
  • Jon S Lindstrom
  • Ron J Lukas
  • William Kem
  • Mol. Pharmacol..2020 May;mol.119.118786. doi: 10.1124/mol.119.118786.Epub 2020-05-30.

キク科Arctium lappa L. (Arctium lappa L.)のマンソニ桿菌および単純ヘルペスウイルス-1に対するin vitroの分裂毒殺および抗ウイルス活性

In vitro schistosomicidal and antiviral activities of Arctium lappa L. (Asteraceae) against Schistosoma mansoni and Herpes simplex virus-1.
  • Mirna Meana Dias
  • Ohana Zuza
  • Lorena R Riani
  • Priscila de Faria Pinto
  • Pedro Luiz Silva Pinto
  • Marcos P Silva
  • Josué de Moraes
  • Ana Caroline Z Ataíde
  • Fernanda de Oliveira Silva
  • Alzira Batista Cecílio
  • Ademar A Da Silva Filho
  • Biomed. Pharmacother..2017 Oct;94:489-498. S0753-3322(17)32153-4. doi: 10.1016/j.biopha.2017.07.116.Epub 2017-08-03.

ホルモン状態は、タモキシフェン治療を受けた乳癌患者におけるタモキシフェンとその主要代謝物の血漿中曝露に影響を与える

Hormonal status affects plasma exposure of tamoxifen and its main metabolites in tamoxifen-treated breast cancer patients.
  • João Paulo Bianchi Ximenez
  • Jurandyr Moreira de Andrade
  • Maria Paula Marques
  • Eduardo Barbosa Coelho
  • Guilherme Suarez-Kurtz
  • Vera Lucia Lanchote
  • BMC Pharmacol Toxicol.2019 12;20(Suppl 1):81. 10.1186/s40360-019-0358-y. doi: 10.1186/s40360-019-0358-y.Epub 2019-12-19.

敗血症性ショック患者におけるトリプトファン経路の異化産物(セロトニン、5-ヒドロキシインドラ酢酸、キヌレニン)および酵素(モノアミンオキシダーゼおよびインドールアミン2,3ジオキシゲナーゼ):前向き観察研究対健常対照

Tryptophan pathway catabolites (serotonin, 5-hydroxyindolacetic acid, kynurenine) and enzymes (monoamine oxidase and indole amine 2,3 dioxygenase) in patients with septic shock: A prospective observational study versus healthy controls.
  • Gilles Troché
  • Matthieu Henry-Lagarrigue
  • Frédérique Soppelsa
  • Stephane Legriel
  • Aihem Yehia
  • Fabrice Bruneel
  • Jean-Pierre Bédos
  • Odile Spreux-Varoquaux
  • Medicine (Baltimore).2020 May;99(19):e19906. 00005792-202005080-00010. doi: 10.1097/MD.0000000000019906.