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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

一過性受容体電位 バニロイドチャネルは、NADPHオキシダーゼ4を介した酸化還元シグナルを調節することで、線維芽細胞の分化や気道リモデリングを制御しています

Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4.
  • Nosayba Al-Azzam
  • Lakshminarayan Reddy Teegala
  • Sabita Pokhrel
  • Samrawit Ghebreigziabher
  • Tatiana Chachkovskyy
  • Sathwika Thodeti
  • Ignacio Gavilanes
  • Kayla Covington
  • Charles K Thodeti
  • Sailaja Paruchuri
  • Sci Rep.2020 Jun;10(1):9827. 10.1038/s41598-020-66617-2. doi: 10.1038/s41598-020-66617-2.Epub 2020-06-17.

新しい選択的オートファジー受容体CCDC50は、ウイルス感染中に分解のためにK63ポリユビキチン化活性化されたRIG-I/MDA5を送達する

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection.
  • Panpan Hou
  • Kongxiang Yang
  • Penghui Jia
  • Lan Liu
  • Yuxin Lin
  • Zibo Li
  • Jun Li
  • Shuliang Chen
  • Shuting Guo
  • Ji'An Pan
  • Junyu Wu
  • Hong Peng
  • Weijie Zeng
  • Chunmei Li
  • Yingfang Liu
  • Deyin Guo
  • Cell Res..2020 Jul;10.1038/s41422-020-0362-1. doi: 10.1038/s41422-020-0362-1.Epub 2020-07-01.

6'-β-フルオロ-ホモアリステロマイシンおよび6'-フルオロ-ホモネプラノシンAは、ウイルス非構造タンパク質1に対する直接的な効果を介してチクングニヤウイルス複製の強力な阻害剤である

6'-β-Fluoro-Homoaristeromycin and 6'-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 1.
  • Kristina Kovacikova
  • Bas M Morren
  • Ali Tas
  • Irina C Albulescu
  • Robin van Rijswijk
  • Dnyandev B Jarhad
  • Young Sup Shin
  • Min Hwan Jang
  • Gyudong Kim
  • Hyuk Woo Lee
  • Lak Shin Jeong
  • Eric J Snijder
  • Martijn J van Hemert
  • Antimicrob. Agents Chemother..2020 03;64(4). e02532-19. doi: 10.1128/AAC.02532-19.Epub 2020-03-24.

周期的電界-フロー分画を用いた差動遠心によって分離されたヒト神経膠芽腫と正常血漿由来の細胞外小胞の特性評価

Characterization of Human Glioblastoma versus Normal Plasma-Derived Extracellular Vesicles Preisolated by Differential Centrifugation Using Cyclical Electrical Field-Flow Fractionation.
  • Farhad Shiri
  • Bruce K Gale
  • Himanshu Sant
  • Gina T Bardi
  • Joshua L Hood
  • Kevin E Petersen
  • Anal. Chem..2020 Jul;doi: 10.1021/acs.analchem.0c01373.Epub 2020-07-07.

エチオピア、アムハラ州北シェワ地区の障害者における家族計画の知識、態度、実践のレベルと関連因子

Level of knowledge, attitude, and practice of family planning and associated factors among disabled persons, north-shewa zone, Amhara regional state, Ethiopia.
  • Alemayehu Gonie Mekonnen
  • Alebachew Demelash Bayleyegn
  • Yared Asmare Aynalem
  • Tigist Demssew Adane
  • Mikyas Arega Muluneh
  • Meaza Asefa
  • Contracept Reprod Med.2020;5:8. 111. doi: 10.1186/s40834-020-00111-y.Epub 2020-07-01.

カロリー制限肥満ラットの肥満治療におけるローヤルゼリーとトコトリエノールリッチフラクションの効果:白色脂肪の褐変特性と発熱能に着目した

Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity.
  • Naimeh Mesri Alamdari
  • Pardis Irandoost
  • Neda Roshanravan
  • Mohammadreza Vafa
  • Mohammad Asghari Jafarabadi
  • Shahriar Alipour
  • Leila Roshangar
  • Mohammadreza Alivand
  • Farnaz Farsi
  • Farzad Shidfar
  • Nutr Metab (Lond).2020;17:42. 458. doi: 10.1186/s12986-020-00458-8.Epub 2020-06-01.

障害者の対象となる雇用に関する医学的・法的考察と産業医学的問題:規制の見直し、現在の社会的・医学的運用ガイドライン、および現在の適用現象

[Medico-legal considerations and occupational medicine issues regarding the targeted employment of disabled persons: regulatory review, current social and medical operational guidelines and current application phenomena].
  • Michele Sammicheli
  • Marcella Scaglione
  • G Ital Med Lav Ergon.2020 Mar;42(1):60-67. GIMLEv42i9.

チクングニヤウイルスとマヤロウイルスの共感染後の血清学的調査のロバスト性

Robustness of Serologic Investigations for Chikungunya and Mayaro Viruses following Coemergence.
  • Carlo Fischer
  • Fernando Bozza
  • Xiomara Jeanleny Merino Merino
  • Celia Pedroso
  • Edmilson F de Oliveira Filho
  • Andrés Moreira-Soto
  • Alvaro Schwalb
  • Xavier de Lamballerie
  • Eduardo Martins Netto
  • Patrícia T Bozza
  • Manoel Sarno
  • Carlos Brites
  • Eduardo Gotuzzo
  • Michael Talledo
  • Jan Felix Drexler
  • mSphere.2020 02;5(1). e00915-19. doi: 10.1128/mSphere.00915-19.Epub 2020-02-05.

感覚障害者がプライマリ・ヘルスケアでケアするためのコミュニケーションの障壁とファシリテーター:マルチレベル研究

Barriers to and facilitators of communication to care for people with sensory disabilities in primary health care: a multilevel study.
  • Aline Macarevich Condessa
  • Jessye Melgarejo do Amaral Giordani
  • Matheus Neves
  • Fernando Neves Hugo
  • Juliana Balbinot Hilgert
  • Rev Bras Epidemiol.2020;23:e200074. S1415-790X2020000100460. doi: 10.1590/1980-549720200074.Epub 2020-07-06.

ヘルシーママ II トライアルの根拠、デザイン、ベースラインデータ。産後うつの予防のための運動とウェルネス介入の有効性を検討する無作為化試験

Rationale, design, and baseline data for the Healthy Mom II Trial: A randomized trial examining the efficacy of exercise and wellness interventions for the prevention of postpartum depression.
  • Beth A Lewis
  • Katie Schuver
  • Shira Dunsiger
  • Lauren Samson
  • Amanda L Frayeh
  • Carrie A Terrell
  • Joseph T Ciccolo
  • Melissa D Avery
  • Contemp Clin Trials.2018 07;70:15-23. S1551-7144(18)30049-1. doi: 10.1016/j.cct.2018.05.002.Epub 2018-05-07.

多発性硬化症患者のコホートにおける社会的距離の維持および個人用保護具の使用と SARS-CoV-2 感染のリスク

Adherence to social distancing and use of personal protective equipment and the risk of SARS-CoV-2 infection in a cohort of patients with multiple sclerosis.
  • Landi D
  • Ponzano M
  • Nicoletti Cg
  • Cecchi G
  • Cola G
  • Mataluni G
  • Mercuri Nb
  • Sormani Mp
  • Marfia Ga
  • Mult Scler Relat Disord.2020 Jul;45:102359. S2211-0348(20)30434-X. doi: 10.1016/j.msard.2020.102359.Epub 2020-07-03.

アルツハイマー病のストレプトゾトシン誘発マウスモデルにおけるロシグリタゾン包埋ナノキャリアシステムの神経保護の可能性を探る

Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease.
  • Sarathlal K C
  • Violina Kakoty
  • Sandhya Marathe
  • Deepak Chitkara
  • Rajeev Taliyan
  • Neurotox Res.2020 Jul;10.1007/s12640-020-00258-1. doi: 10.1007/s12640-020-00258-1.Epub 2020-07-18.

腫瘍関連抗原を認識する少数のT細胞は、自己HLAで提示された腫瘍関連抗原を認識することで、抗腫瘍反応を誘発することができる

A Minority of T Cells Recognizing Tumor-Associated Antigens Presented in Self-HLA Can Provoke Anti-Tumor Reactivity.
  • Marthe C J Roex
  • Lois Hageman
  • Sabrina Veld
  • H M Esther van Egmond
  • Conny Hoogstraten
  • Christian Stemberger
  • Lothar Germeroth
  • Hermann Einsele
  • J H Frederik Falkenburg
  • Inge Jedema
  • Blood.2020 Jun;blood.2019004443. doi: 10.1182/blood.2019004443.Epub 2020-06-01.

トルフェナム酸は卵巣がん細胞の増殖を抑制し、特異性タンパク質転写因子を抑制することでc-Metやサバイビンの発現を低下させます

Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors.
  • Riyaz Basha
  • Susan B Ingersoll
  • Umesh T Sankpal
  • Sarfraz Ahmad
  • Cheryl H Baker
  • John R Edwards
  • Robert W Holloway
  • Sumanth Kaja
  • Maen Abdelrahim
  • Gynecol. Oncol..2011 Jul;122(1):163-70. S0090-8258(11)00189-2. doi: 10.1016/j.ygyno.2011.03.014.Epub 2011-04-15.

牛未経産牛の妊娠初期における末梢血単核細胞および多形核白血球におけるI型インターフェロン受容体およびインターフェロンτ刺激遺伝子の発現

Type I interferon receptors and interferon-τ-stimulated genes in peripheral blood mononuclear cells and polymorphonuclear leucocytes during early pregnancy in beef heifers.
  • G D Melo
  • L M F Pinto
  • C C Rocha
  • I G Motta
  • L A Silva
  • J C da Silveira
  • A M Gonella-Diaza
  • M Binelli
  • G Pugliesi
  • Reprod. Fertil. Dev..2020 Jul;RD19430. doi: 10.1071/RD19430.Epub 2020-07-10.

社内シロップ製剤中の逆相hplcによるデキストロメトルファン臭化水素酸塩とデスロラタジンの同時多変量定量法の開発とバリデーションのためのボックスベーンケンデザインアシストメソッドの開発とバリデーション

A multivariate quantification of box behnken design assisted method development and validation of dextromethorphan hydrobromide and desloratadine simultaneously by reverse phase hplc in in-house syrup formulation.
  • Md Irshad Alam
  • Aquil Ur-Rahim Siddiqui
  • Nazia Khanam
  • Shaikh Jalil Kamaruddin
  • J Sep Sci.2020 Jul;doi: 10.1002/jssc.202000510.Epub 2020-07-19.

COVID-19を識別するための鼻閉塞を伴わない自己申告による嗅覚喪失。多施設共同CORANOSMIAコホート研究

Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter CORANOSMIA cohort study.
  • Dominique Salmon
  • Sophie Bartier
  • Charlotte Hautefort
  • Yann Nguyen
  • Jérôme Nevoux
  • Anne-Laure Hamel
  • Yohan Camhi
  • Florence Canouï-Poitrine
  • Benjamin Verillaud
  • Dorsaf Slama
  • Stephanie Haim-Boukobza
  • Elise Sourdeau
  • Delphine Cantin
  • Alain Corré
  • Agnes Bryn
  • Nicolas Etienne
  • Flore Rozenberg
  • Richard Layese
  • Jean-François Papon
  • Emilie Bequignon
  • J. Infect..2020 Jul;S0163-4453(20)30463-1. doi: 10.1016/j.jinf.2020.07.005.Epub 2020-07-07.

Trp53欠損マウスにおける高エネルギー放射線および低エネルギー放射線によって誘発される腫瘍の変異シグネチャー

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice.
  • Yun Rose Li
  • Kyle D Halliwill
  • Cassandra J Adams
  • Vivek Iyer
  • Laura Riva
  • Rashid Mamunur
  • Kuang-Yu Jen
  • Reyno Del Rosario
  • Erik Fredlund
  • Gillian Hirst
  • Ludmil B Alexandrov
  • David Adams
  • Allan Balmain
  • Nat Commun.2020 01;11(1):394. 10.1038/s41467-019-14261-4. doi: 10.1038/s41467-019-14261-4.Epub 2020-01-20.

長期人工呼吸器の使用が健康関連の生活の質と神経筋疾患の子どもとその家族のメンタルヘルスに与える影響:視点の見直しが必要か?

The impact of long-term ventilator-use on health-related quality of life and the mental health of children with neuromuscular diseases and their families: need for a revised perspective?
  • Jessika Johannsen
  • Lena Fuhrmann
  • Benjamin Grolle
  • Lydia Morgenstern
  • Silke Wiegand-Grefe
  • Jonas Denecke
  • Health Qual Life Outcomes.2020 Jul;18(1):219. 10.1186/s12955-020-01467-0. doi: 10.1186/s12955-020-01467-0.Epub 2020-07-09.

COVID-19でより難易度の高いラピッドレビュー手法。8つの知識合成ステップに焦点を当てた解説

Rapid review methods more challenging during COVID-19: Commentary with a focus on 8 knowledge synthesis steps.
  • Andrea C Tricco
  • Chantelle M Garritty
  • Leah Boulos
  • Craig Lockwood
  • Michael Wilson
  • Jessie McGowan
  • Michael McCaul
  • Brian Hutton
  • Fiona Clement
  • Nicole Mittmann
  • Declan Devane
  • Etienne V Langlois
  • Ahmed M Abou-Setta
  • Catherine Houghton
  • Claire Glenton
  • Shannon E Kelly
  • Vivian A Welch
  • Annie LeBlanc
  • George A Wells
  • Ba' Pham
  • Simon Lewin
  • Sharon E Straus
  • J Clin Epidemiol.2020 Jun;S0895-4356(20)30616-8. doi: 10.1016/j.jclinepi.2020.06.029.Epub 2020-06-29.

トルコにおける幼児期の発達と発達障害への対応:発達小児科ユニットのトレーニングプログラム

Addressing early childhood development and developmental difficulties in Turkey: a training programfor developmental pediatrics units.
  • Emine B Bingoler Pekcici
  • Ezgi Özalp Akin
  • Iclal Ayranci Sucakli
  • Gizem Kara Elitok
  • Fatma N Onat
  • Meltem Kivilcime
  • Zeynep Ustunyurt
  • Revan Mustafayev
  • Ilgi Ozturk Ertem
  • Arch Argent Pediatr.2020 Aug;118(4):e384-e391. doi: 10.5546/aap.2020.eng.e384.

思春期前のシクロホスファミド曝露による精子形成、ステロイド形成、精巣構造のミューティレーションがSDラットで認められた。代替ハーブバイアグラからの保護

Pre-pubertal cyclophosphamide exposure-induced mutilation in spermatogenesis, steroidogenesis and testicular architecture in SD rat: Protection from an alternative herbal viagra.
  • Ramanachary Namoju
  • Naga Kavitha Chilaka
  • Durga Prasad Beda
  • Srinivasa Rao Avanapu
  • Rev Int Androl.2020 Jul;S1698-031X(20)30035-2. doi: 10.1016/j.androl.2020.01.009.Epub 2020-07-15.

過体重/肥満の青年期のインスリン抵抗性に対する高タンパク/低血糖指標食の効果-PREVIEW無作為化臨床試験

Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity-A PREVIEW randomized clinical trial.
  • Elke Dorenbos
  • Mathijs Drummen
  • Tanja Adam
  • Jesse Rijks
  • Bjorn Winkens
  • J Alfredo Martínez
  • Santiago Navas-Carretero
  • Gareth Stratton
  • Nils Swindell
  • Pauline Stouthart
  • Kelly Mackintosh
  • Melitta Mcnarry
  • Angelo Tremblay
  • Mikael Fogelholm
  • Anne Raben
  • Margriet Westerterp-Plantenga
  • Anita Vreugdenhil
  • Pediatr Obes.2020 Jul;:e12702. doi: 10.1111/ijpo.12702.Epub 2020-07-17.

SNHG20のノックダウンは、miR-2467-3p/E2F3を制御することで、増殖・移行・浸潤を抑制し、アポトーシスを誘導することで、非小細胞肺癌の発生を抑制することが明らかになった

Knockdown SNHG20 Suppresses Nonsmall Cell Lung Cancer Development by Repressing Proliferation, Migration and Invasion, and Inducing Apoptosis by Regulating miR-2467-3p/E2F3.
  • Hang Chen
  • Xin Tan
  • Yi Ding
  • Cancer Biother. Radiopharm..2020 May;doi: 10.1089/cbr.2019.3430.Epub 2020-05-25.

広範囲な病変の偏析ががんゲノムの進化を形作る

Pervasive lesion segregation shapes cancer genome evolution.
  • Sarah J Aitken
  • Craig J Anderson
  • Frances Connor
  • Oriol Pich
  • Vasavi Sundaram
  • Christine Feig
  • Tim F Rayner
  • Margus Lukk
  • Stuart Aitken
  • Juliet Luft
  • Elissavet Kentepozidou
  • Claudia Arnedo-Pac
  • Sjoerd V Beentjes
  • Susan E Davies
  • Ruben M Drews
  • Ailith Ewing
  • Vera B Kaiser
  • Ava Khamseh
  • Erika López-Arribillaga
  • Aisling M Redmond
  • Javier Santoyo-Lopez
  • Inés Sentís
  • Lana Talmane
  • Andrew D Yates
  • Colin A Semple
  • Núria López-Bigas
  • Paul Flicek
  • Duncan T Odom
  • Martin S Taylor
  • Nature.2020 07;583(7815):265-270. 10.1038/s41586-020-2435-1. doi: 10.1038/s41586-020-2435-1.Epub 2020-06-24.

経皮的冠動脈インターベンション後の急性冠症候群患者におけるマルチジーン薬理遺伝学的検査の費用対効果.

Cost-Effectiveness of Multigene Pharmacogenetic Testing in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention.
  • Olivia M Dong
  • Stephanie B Wheeler
  • Gracelyn Cruden
  • Craig R Lee
  • Deepak Voora
  • Stacie B Dusetzina
  • Tim Wiltshire
  • Value Health.2020 01;23(1):61-73. S1098-3015(19)32344-7. doi: 10.1016/j.jval.2019.08.002.Epub 2019-09-25.

トリプルネガティブ乳癌に対する MR/蛍光イメージングおよび強化された光力学的治療のためのフィブロネクチン標的化およびカテプシン B 活性化可能な治療法ナノプローブ

Fibronectin-Targeting and Cathepsin B-Activatable Theranostic Nanoprobe for MR/Fluorescence Imaging and Enhanced Photodynamic Therapy for Triple Negative Breast Cancer.
  • Yanshu Wang
  • Liping Jiang
  • Yuwen Zhang
  • Yimei Lu
  • Jinning Li
  • He Wang
  • Defan Yao
  • Dengbin Wang
  • ACS Appl Mater Interfaces.2020 Jul;doi: 10.1021/acsami.0c10397.Epub 2020-07-20.

BRCA 変異キャリアにおけるラジオミクスと機械学習を用いた MRI 上のセンチ以下の増強乳房腫瘤の特徴付けの改善

Improved characterization of sub-centimeter enhancing breast masses on MRI with radiomics and machine learning in BRCA mutation carriers.
  • Roberto Lo Gullo
  • Isaac Daimiel
  • Carolina Rossi Saccarelli
  • Almir Bitencourt
  • Peter Gibbs
  • Michael J Fox
  • Sunitha B Thakur
  • Danny F Martinez
  • Maxine S Jochelson
  • Elizabeth A Morris
  • Katja Pinker
  • Eur Radiol.2020 Jun;10.1007/s00330-020-06991-7. doi: 10.1007/s00330-020-06991-7.Epub 2020-06-27.

リン酸ナトリウムの経口負荷が非正常および高カルシウム血症の結石形成患者における副甲状腺ホルモンおよび線維芽細胞増殖因子23の分泌に及ぼす影響

The effect of an oral sodium phosphate load on parathyroid hormone and fibroblast growth factor 23 secretion in normo- and hypercalciuric stone-forming patients.
  • Tomasz Irzyniec
  • Monika Boryń
  • Joanna Kasztalska
  • Zofia Nowak-Kapusta
  • Izabela Maciejewska-Paszek
  • Elżbieta Grochowska-Niedworok
  • Clin Nutr.2020 Apr;S0261-5614(20)30191-6. doi: 10.1016/j.clnu.2020.04.020.Epub 2020-04-21.

非小細胞肺がんに対するユニポータルビデオ支援胸部外科的葉切除術後の胸膜ドレナージ量の予測因子:単施設レトロスペクティブ研究

Predictive factors for pleural drainage volume after uniportal video-assisted thoracic surgery lobectomy for non-small cell lung cancer: a single-institution retrospective study.
  • Ming-Bo Tang
  • Jia-Lin Li
  • Su-Yan Tian
  • Xin-Liang Gao
  • Wei Liu
  • World J Surg Oncol.2020 Jul;18(1):162. 10.1186/s12957-020-01941-5. doi: 10.1186/s12957-020-01941-5.Epub 2020-07-08.

血液脳関門における差異発現は、AAV-PHP.B.の菌株特異的中枢神経系トランスダクションプロファイルに責任がある

Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B.
  • Ana Rita Batista
  • Oliver D King
  • Christopher P Reardon
  • Crystal Davis
  • Shankaracharya
  • Vivek Philip
  • Heather Gray-Edwards
  • Neil Aronin
  • Cathleen Lutz
  • John Landers
  • Miguel Sena-Esteves
  • Hum. Gene Ther..2020 Jan;31(1-2):90-102. doi: 10.1089/hum.2019.186.Epub 2019-12-13.

MnO粉末による低線量放射線被曝はラットの精巣と前立腺の遺伝子発現を変化させる

Low-Dose Radiation Exposure with MnO Powder Changes Gene Expressions in the Testes and the Prostate in Rats.
  • Nariaki Fujimoto
  • Gaukhar Amantayeva
  • Nailya Chaizhunussova
  • Dariya Shabdarbayeva
  • Zhaslan Abishev
  • Bakhyt Ruslanova
  • Yersin Zhunussov
  • Almas Azhimkhanov
  • Kassym Zhumadilov
  • Aleksey Petukhov
  • Valeriy Stepanenko
  • Masaharu Hoshi
  • Int J Mol Sci.2020 Jul;21(14). E4989. doi: 10.3390/ijms21144989.Epub 2020-07-15.

進化的解析により、イネL-ミオイノシトール1リン酸合成酵素の触媒活性に不可欠な2つのリジン残基を含む保存されたペンタペプチド配列が同定された

An evolutionary analysis identifies a conserved pentapeptide stretch containing the two essential lysine residues for rice L-myo-inositol 1-phosphate synthase catalytic activity.
  • Papri Basak
  • Susmita Maitra-Majee
  • Jayanta Kumar Das
  • Abhishek Mukherjee
  • Shubhra Ghosh Dastidar
  • Pabitra Pal Choudhury
  • Arun Lahiri Majumder
  • PLoS ONE.2017;12(9):e0185351. PONE-D-17-03012. doi: 10.1371/journal.pone.0185351.Epub 2017-09-26.

選択的消化管除染を受けた集中治療患者と健常者の腸内細菌叢とレジストームプロファイリングの比較

Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
  • Elena Buelow
  • Teresita D J Bello González
  • Susana Fuentes
  • Wouter A A de Steenhuijsen Piters
  • Leo Lahti
  • Jumamurat R Bayjanov
  • Eline A M Majoor
  • Johanna C Braat
  • Maaike S M van Mourik
  • Evelien A N Oostdijk
  • Rob J L Willems
  • Marc J M Bonten
  • Mark W J van Passel
  • Hauke Smidt
  • Willem van Schaik
  • Microbiome.2017 08;5(1):88. 10.1186/s40168-017-0309-z. doi: 10.1186/s40168-017-0309-z.Epub 2017-08-14.

肥大から不全への移行期における左室応答は、大動脈弁逆流症マウスにおけるAkt、β-アレスチン-2、CaMKIIの異なる役割を再現している

Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation.
  • Jian Wu
  • Jieyun You
  • Xiaoyan Wang
  • Shijun Wang
  • Jiayuan Huang
  • Qihai Xie
  • Baoyong Gong
  • Zhiwen Ding
  • Yong Ye
  • Cong Wang
  • Le Kang
  • Ran Xu
  • Yang Li
  • Ruizhen Chen
  • Aijun Sun
  • Xiangdong Yang
  • Hong Jiang
  • Fenghua Yang
  • Peter H Backx
  • Junbo Ge
  • Yunzeng Zou
  • Ann Transl Med.2020 Mar;8(5):219. atm-08-05-219. doi: 10.21037/atm.2020.01.51.

食事の全血DNAメチル化シグネチャーは、心血管疾患のリスク因子と全原因死亡率と関連している

Whole Blood DNA Methylation Signatures of Diet Are Associated with Cardiovascular Disease Risk Factors and All-cause Mortality.
  • Jiantao Ma
  • Casey M Rebholz
  • Kim V E Braun
  • Lindsay M Reynolds
  • Stella Aslibekyan
  • Rui Xia
  • Niranjan G Biligowda
  • Tianxiao Huan
  • Chunyu Liu
  • Michael M Mendelson
  • Roby Joehanes
  • Emily A Hu
  • Mara Z Vitolins
  • Alexis C Wood
  • Kurt Lohman
  • Carolina Ochoa-Rosales
  • Joyce van Meurs
  • André Uitterlinden
  • Yongmei Liu
  • Mohamed A Elhadad
  • Margit Heier
  • Melanie Waldenberger
  • Annette Peters
  • Elena Colicino
  • Eric A Whitsel
  • Antoine Baldassari
  • Sina A Gharib
  • Nona Sotoodehnia
  • Jennifer A Brody
  • Colleen M Sitlani
  • Toshiko Tanaka
  • W David Hill
  • Janie Corley
  • Ian J Deary
  • Yan Zhang
  • Ben Schöttker
  • Hermann Brenner
  • Maura E Walker
  • Shumao Ye
  • Steve Nguyen
  • Jim Pankow
  • Ellen W Demerath
  • Yinan Zheng
  • Lifang Hou
  • Liming Liang
  • Alice H Lichtenstein
  • Frank B Hu
  • Myriam Fornage
  • Trudy Voortman
  • Daniel Levy
  • Circ Genom Precis Med.2020 Jun;doi: 10.1161/CIRCGEN.119.002766.Epub 2020-06-11.

Sm遺伝子のゲノムワイドな同定と発現解析により、Dimocarpus longan Lourの初期体性胚発生に関与していることが明らかになった

Genome-wide identification and expression analyses of Sm genes reveal their involvement in early somatic embryogenesis in Dimocarpus longan Lour.
  • Xue Li
  • Yan Chen
  • Shuting Zhang
  • Liyao Su
  • Xiaoping Xu
  • Xiaohui Chen
  • Zhongxiong Lai
  • Yuling Lin
  • PLoS ONE.2020;15(4):e0230795. PONE-D-20-00319. doi: 10.1371/journal.pone.0230795.Epub 2020-04-03.

Bialowieza原始原生林のバイソンにおける肝臓フルークのミトコンドリアDNAハプロタイプ解析により、家畜が感染源である可能性が示唆された

Mitochondrial DNA haplotype analysis of liver fluke in bison from Bialowieza Primaeval Forest indicates domestic cattle as the likely source of infection.
  • Stephen M Walker
  • Aleksander W Demiaszkiewicz
  • Monika Kozak
  • Halina Wedrychowicz
  • Denitsa Teofanova
  • Paulo Prodohl
  • Gerry Brennan
  • Ian Fairweather
  • Elizabeth M Hoey
  • Alan Trudgett
  • Vet. Parasitol..2013 Jan;191(1-2):161-4. S0304-4017(12)00415-3. doi: 10.1016/j.vetpar.2012.08.002.Epub 2012-08-09.

アンドロゲンは、思春期の雄ラットのCA1海馬下野の錐体神経細胞の内在性可塑性のダイナミクスに影響を与える

Androgen Affects the Dynamics of Intrinsic Plasticity of Pyramidal Neurons in the CA1 Hippocampal Subfield in Adolescent Male Rats.
  • Md Nabiul Islam
  • Yuya Sakimoto
  • Mir Rubayet Jahan
  • Mako Ishida
  • Abu Md Mamun Tarif
  • Kanako Nozaki
  • Koh-Hei Masumoto
  • Akie Yanai
  • Dai Mitsushima
  • Koh Shinoda
  • Neuroscience.2020 Aug;440:15-29. S0306-4522(20)30319-5. doi: 10.1016/j.neuroscience.2020.05.025.Epub 2020-05-23.

子豚(離乳)、肥育用鶏、産卵用に飼育された鶏、肥育用七面鳥、繁殖用に飼育された七面鳥の飼料添加物としての ECONASEXT (endo-1,4-β-キシラナーゼ) の認可更新申請の評価

Assessment of the application for renewal of authorisation of ECONASEXT (endo-1,4-β-xylanase) as a feed additive for piglets (weaned), chickens for fattening, chickens reared for laying, turkeys for fattening and turkeys reared for breeding.
  • Vasileios Bampidis
  • Giovanna Azimonti
  • Maria de Lourdes Bastos
  • Henrik Christensen
  • Birgit Dusemund
  • Maryline Kouba
  • Mojca Kos Durjava
  • Marta López-Alonso
  • Secundino López Puente
  • Francesca Marcon
  • Baltasar Mayo
  • Alena Pechová
  • Mariana Petkova
  • Fernando Ramos
  • Yolanda Sanz
  • Roberto Villa
  • Ruud Woutersen
  • Pier Sandro Cocconcelli
  • Boet Glandorf
  • Lieve Herman
  • Miguel Maradona Prieto
  • Maria Saarela
  • Jaume Galobart
  • Lucilla Gregoretti
  • Matteo Lorenzo Innocenti
  • Gloria López Gálvez
  • Konstantinos Sofianidis
  • Maria Vittoria Vettori
  • Rosella Brozzi
  • EFSA J.2019 Nov;17(11):e05880. EFS25880. doi: 10.2903/j.efsa.2019.5880.Epub 2019-11-07.

茶ポリフェノールは、海馬ニューロンにおけるBDNF-TrkB/AktおよびErk1/2シグナル伝達軸を調節することにより、スタウロスポリン誘発細胞毒性およびアポトーシスを減衰させる

Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.
  • Jian-Rong Yang
  • Teng-Teng Ren
  • Rongfeng Lan
  • Xiao-Yan Qin
  • IBRO Rep.2020 Jun;8:115-121. S2451-8301(20)30012-1. doi: 10.1016/j.ibror.2020.04.002.Epub 2020-04-19.

機械学習と知識工学を用いた電子カルテにおける希少疾患の検出急性肝ポルフィリン症のケーススタディ

Detecting rare diseases in electronic health records using machine learning and knowledge engineering: Case study of acute hepatic porphyria.
  • Aaron M Cohen
  • Steven Chamberlin
  • Thomas Deloughery
  • Michelle Nguyen
  • Steven Bedrick
  • Stephen Meninger
  • John J Ko
  • Jigar J Amin
  • Alex J Wei
  • William Hersh
  • PLoS ONE.2020;15(7):e0235574. PONE-D-20-10338. doi: 10.1371/journal.pone.0235574.Epub 2020-07-02.

急性心筋梗塞を有するブタの再灌流に先立って同種心筋細胞の冠動脈内投与は、梗塞サイズを減少させ、心臓リモデリングの悪化を抑制する

Intracoronary Administration of Allogeneic Cardiosphere-Derived Cells Immediately Prior to Reperfusion in Pigs With Acute Myocardial Infarction Reduces Infarct Size and Attenuates Adverse Cardiac Remodeling.
  • Vasileios Sousonis
  • Titika Sfakianaki
  • Argirios Ntalianis
  • Ioannis Nanas
  • Christos Kontogiannis
  • Dionysios Aravantinos
  • Chris Kapelios
  • Lampros Katsaros
  • Maria Nana
  • Dimitrios Sampaziotis
  • Despina Sanoudou
  • Apostolos Papalois
  • Konstantinos Malliaras
  • J. Cardiovasc. Pharmacol. Ther..2020 Jul;:1074248420941672. doi: 10.1177/1074248420941672.Epub 2020-07-17.

X線結晶学、IR/Raman分光学、周期的DFTを組み合わせた新規多成分制吐剤結晶形態の研究。マレイン酸カルベンダジムを例にして

Combined X-ray Crystallographic, IR/Raman Spectroscopic, and Periodic DFT Investigations of New Multicomponent Crystalline Forms of Anthelmintic Drugs: A Case Study of Carbendazim Maleate.
  • Alexander P Voronin
  • Artem O Surov
  • Andrei V Churakov
  • Olga D Parashchuk
  • Alexey A Rykounov
  • Mikhail V Vener
  • Molecules.2020 May;25(10). E2386. doi: 10.3390/molecules25102386.Epub 2020-05-21.

発作性夜行性ヘモグロビン尿症:プレドニゾンにするか、プレドニゾンにしないか--以前に15年間ステロイドで治療された患者の症例報告とエクリズマブでの有意な反応

Paroxysmal nocturnal haemoglobinuria: to prednisone or not to prednisone?--a case report of a patient previously treated with steroids for 15 yrs and significant response on eculizumab.
  • Alexander Röth
  • Ferras Alashkar
  • Dörte Herich-Terhürne
  • Ulrich Dührsen
  • Eur. J. Haematol..2015 Aug;95(2):177-80. doi: 10.1111/ejh.12480.Epub 2015-03-29.