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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

ラット遠位結腸では、平行中間コンダクタンスKとClチャネルの活性が基底側膜を横切ってエレクトロンニュートラルKの出口を媒介している

Parallel intermediate conductance K and Cl channel activity mediates electroneutral K exit across basolateral membranes in rat distal colon.
  • Shabina Rehman
  • Karthikeyan Narayanan
  • Andrew J Nickerson
  • Steven D Coon
  • Kazi Mirajul Hoque
  • Geoffrey I Sandle
  • Vazhaikkurichi M Rajendran
  • Am. J. Physiol. Gastrointest. Liver Physiol..2020 Aug;319(2):G142-G150. doi: 10.1152/ajpgi.00011.2020.Epub 2020-06-22.

解説。p-トルエンスルホン酸/塩化コリン深層共晶溶媒を加水分解媒体として用いた棒状キチンナノ結晶の調製、特性評価、応用

Commentary: Preparation, characterization and application of rod-like chitin nanocrystal by using p-toluenesulfonic acid/choline chloride deep eutectic solvent as a hydrolytic media.
  • Wen-Hao Jiang
  • Wei-Ming Gu
  • Mei-Jie Xiong
  • Kang-Ping He
  • Xiao-Ying Xu
  • Wen-Xi Zhang
  • Rui-Feng Shen
  • Lin-Hao Lai
  • Yong-Si Lv
  • Shi-Lin Cao
  • Front Bioeng Biotechnol.2020;8:505. doi: 10.3389/fbioe.2020.00505.Epub 2020-06-12.

患者中心のケアのための機会。慢性疾患を対象としたモバイルヘルス試験における性と性別に基づくデータの二次分析の結果

An opportunity for patient-centered care: Results from a secondary analysis of sex- and gender-based data in mobile health trials for chronic medical conditions.
  • Jiani Wang
  • Jürgen Barth
  • Irene Göttgens
  • Karma Emchi
  • Daniel Pach
  • Sabine Oertelt-Prigione
  • Maturitas.2020 Aug;138:1-7. S0378-5122(20)30260-7. doi: 10.1016/j.maturitas.2020.05.003.Epub 2020-05-12.

白血球比は、急性肝硬変および急性-慢性肝不全の急性分解性肝硬変患者における死亡率のバイオマーカーである

Leucocyte ratios are biomarkers of mortality in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure.
  • Christine Bernsmeier
  • Anna Cavazza
  • Evangelia M Fatourou
  • Eleni Theocharidou
  • Abisoye Akintimehin
  • Benjamin Baumgartner
  • Ameet Dhar
  • Georg Auzinger
  • Mark Thursz
  • William Bernal
  • Julia A Wendon
  • Constantine J Karvellas
  • Charalambos G Antoniades
  • Mark J W McPhail
  • Aliment. Pharmacol. Ther..2020 Jul;doi: 10.1111/apt.15932.Epub 2020-07-19.

Tityus stigmurus毒は、血液および精巣細胞に遺伝的損傷を与え、マウスの配偶子形成系細胞の数および形態に影響を与える

Tityus stigmurus venom causes genetic damage in blood and testicular cells and affects the number and morphology of gametogenic lineage cells in mice.
  • Meykson A Silva
  • Talita G Souza
  • Maria E G Melo
  • Jeanderson M Silva
  • José R Lima
  • André F A Lira
  • Francisco C A de Aguiar-Júnior
  • René D Martins
  • Roberta J B Jorge
  • Cristiano A Chagas
  • Valéria W Teixeira
  • Álvaro A C Teixeira
  • Toxicon.2020 Jul;S0041-0101(20)30310-X. doi: 10.1016/j.toxicon.2020.07.006.Epub 2020-07-10.

自由フラップ再建を伴う頭頸部手術を受けた患者における多剤併用鎮痛薬投与と周術期オピオイド要求量の関連性

Association Between Multimodal Analgesia Administration and Perioperative Opioid Requirements in Patients Undergoing Head and Neck Surgery With Free Flap Reconstruction.
  • Catherine N Vu
  • Carol M Lewis
  • Neil S Bailard
  • Ravish Kapoor
  • M Laura Rubin
  • Gang Zheng
  • JAMA Otolaryngol Head Neck Surg.2020 Jun;2767511. doi: 10.1001/jamaoto.2020.1170.Epub 2020-06-18.

抽出物の化学療法の可能性:男性ラットにおけるトラマドール長期投与後の抗不妊薬としてのcGMP特異的PDE5阻害剤

Chemotherapeutic Potential of Extract: The cGMP-Specific PDE5 Inhibitor as Anti-Infertility Agent Following Long-Term Administration of Tramadol in Male Rats.
  • Ahmed S Abdelaziz
  • Mohamed A Kamel
  • Amany I Ahmed
  • Shimaa I Shalaby
  • Salama M El-Darier
  • Amany Magdy Beshbishy
  • Gaber El-Saber Batiha
  • Suliman Y Alomar
  • Dina M Khodeer
  • Antibiotics (Basel).2020 Jun;9(6). E318. doi: 10.3390/antibiotics9060318.Epub 2020-06-11.

乳がん患者における腋窩リンパ節摘出術後の術後鎮痛剤投与後の慢性的な副作用:前向き二重盲検無作為化試験の結果

Chronic adverse effects after an axillary lymphadenectomy in breast cancer patients after administering weaker and stronger postoperative analgesia: results of a prospective double-blind randomized study.
  • Nikola Besic
  • Jaka Smrekar
  • Branka Strazisar
  • Breast Cancer Res. Treat..2020 Aug;182(3):655-663. 10.1007/s10549-020-05713-3. doi: 10.1007/s10549-020-05713-3.Epub 2020-06-18.

依存性受容体UNC5Aは、乳がんの腔内から基底部への可塑性と転移を制限する

Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.
  • Maria B Padua
  • Poornima Bhat-Nakshatri
  • Manjushree Anjanappa
  • Mayuri S Prasad
  • Yangyang Hao
  • Xi Rao
  • Sheng Liu
  • Jun Wan
  • Yunlong Liu
  • Kyle McElyea
  • Max Jacobsen
  • George Sandusky
  • Sandra Althouse
  • Susan Perkins
  • Harikrishna Nakshatri
  • Breast Cancer Res..2018 05;20(1):35. 10.1186/s13058-018-0963-5. doi: 10.1186/s13058-018-0963-5.Epub 2018-05-02.

二塩化ラヂウム223で治療されたmCRPC患者の保護因子としての一次根治的前立腺摘出術または切除的放射線治療。イタリアの多施設共同研究

Primary Radical Prostatectomy or Ablative Radiotherapy as Protective Factors for Patients With mCRPC Treated With Radium-223 Dichloride: An Italian Multicenter Study.
  • Viviana Frantellizzi
  • Renato Costa
  • Manlio Mascia
  • Angela Spanu
  • Alessio Farcomeni
  • Maria Licari
  • Luca Cindolo
  • Susanna Nuvoli
  • Mariano Pontico
  • Giuseppe De Vincentis
  • Clin Genitourin Cancer.2020 Jun;18(3):185-191. S1558-7673(19)30313-1. doi: 10.1016/j.clgc.2019.10.009.Epub 2019-10-16.

肺移植患者における胃食道逆流と微小吸引。単一の食道マノメトリーとpHプローブによるモニタリング試験の有用性

Gastroesophageal Reflux and Microaspiration in Lung Transplant Recipients: The Utility of a Single Esophageal Manometry and pH Probe Monitoring Study.
  • J Gualdoni
  • J Ritzenthaler
  • J Burlen
  • A Stocker
  • T Abell
  • J Roman
  • D R Nunley
  • Transplant. Proc..2020 Apr;52(3):977-981. S0041-1345(19)31325-9. doi: 10.1016/j.transproceed.2020.01.019.Epub 2020-03-07.

マイノリティストレスのマルチレベルドメインの検討。男女の性交渉を行うラティーナ女性における薬物使用と心身の健康への示唆

Examination of multilevel domains of minority stress: Implications for drug use and mental and physical health among Latina women who have sex with women and men.
  • Alice Cepeda
  • Kathryn M Nowotny
  • Jessica Frankeberger
  • Esmeralda Ramirez
  • Victoria E Rodriguez
  • Tasha Perdue
  • Avelardo Valdez
  • PLoS ONE.2020;15(3):e0230437. PONE-D-19-19530. doi: 10.1371/journal.pone.0230437.Epub 2020-03-26.

耐久性のある左室補助装置の植え込み時に外科的介入を必要としたImpellaに関連した大動脈不全

Aortic insufficiency associated with Impella that required surgical intervention upon implantation of the durable left ventricular assist device.
  • Hideo Oishi
  • Toru Kondo
  • Kazuro Fujimoto
  • Masato Mutsuga
  • Ryota Morimoto
  • Ken-Ichi Hirano
  • Akinori Sawamura
  • Shingo Kazama
  • Yuki Kimura
  • Naoki Shibata
  • Hiroo Kato
  • Yoshihito Arao
  • Tasuku Kuwayama
  • Shogo Yamaguchi
  • Hiroaki Hiraiwa
  • Takahiro Okumura
  • Akihiko Usui
  • Toyoaki Murohara
  • J Artif Organs.2020 Jun;10.1007/s10047-020-01184-x. doi: 10.1007/s10047-020-01184-x.Epub 2020-06-19.

アデフォビル誘発ファンコーニ症候群による低リン血症性骨軟化症の臨床症状をデノスマブで改善:症例報告

Denosumab improves clinical manifestations of hypophosphatemic osteomalacia by adefovir-induced Fanconi syndrome: a case report.
  • Tomohisa Kunii
  • Toshie Iijima
  • Teruo Jojima
  • Masanori Shimizu
  • Masato Kase
  • Shintaro Sakurai
  • Takahiko Kogai
  • Isao Usui
  • Yoshimasa Aso
  • J Med Case Rep.2019 Apr;13(1):99. 10.1186/s13256-019-2018-7. doi: 10.1186/s13256-019-2018-7.Epub 2019-04-20.

遠隔性は世界中の島々で生物学的侵入を促進しています

Remoteness promotes biological invasions on islands worldwide.
  • Dietmar Moser
  • Bernd Lenzner
  • Patrick Weigelt
  • Wayne Dawson
  • Holger Kreft
  • Jan Pergl
  • Petr Pyšek
  • Mark van Kleunen
  • Marten Winter
  • César Capinha
  • Phillip Cassey
  • Stefan Dullinger
  • Evan P Economo
  • Pablo García-Díaz
  • Benoit Guénard
  • Florian Hofhansl
  • Thomas Mang
  • Hanno Seebens
  • Franz Essl
  • Proc. Natl. Acad. Sci. U.S.A..2018 09;115(37):9270-9275. 1804179115. doi: 10.1073/pnas.1804179115.Epub 2018-08-29.

確認された侵襲性肺アスペルギルス症とCOVID-19:死後の管理を支える死後所見の価値

Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management.
  • Monique Freire Santana
  • Guilherme Pivoto
  • Márcia A Araujo Alexandre
  • Djane Clarys Baía-da-Silva
  • Mayla Gabriela da Silva Borba
  • Fernando Almeida Val
  • Jose Diego Brito-Sousa
  • Gisely Cardoso Melo
  • Wuelton Marcelo Monteiro
  • João Vicente Braga Souza
  • Silviane Bezerra Pinheiro
  • Luiz Carlos Lima Ferreira
  • Felipe Gomes Naveca
  • Valdinete Alves Nascimento
  • André Lima Guerra Corado
  • Ludhmila Abrahão Hajjar
  • João Ricardo Silva Neto
  • George Alan Villarouco Siva
  • Alessandro C Pasqualotto
  • Marcus Vinícius Guimarães Lacerda
  • Rev. Soc. Bras. Med. Trop..2020;53:e20200401. S0037-86822020000100719. doi: 10.1590/0037-8682-0401-2020.Epub 2020-07-03.

扁平上皮肺癌を合併した中隔膜増殖を伴わないモノクローナル免疫グロブリン沈着を伴う増殖性糸球体腎炎

Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma.
  • Takaaki Higashihara
  • Akira Okada
  • Yasuna Nakamura
  • Hanako Saigusa
  • Shiko Homma
  • Mimiko Matsumura
  • Taiko Kusano
  • Akira Shimizu
  • Hideki Takano
  • Intern. Med..2020 Feb;59(4):557-562. doi: 10.2169/internalmedicine.2993-19.Epub 2019-10-15.

光検出性能向上のためのPbS量子ドットを用いたCsPbBrペロブスカイトナノ結晶および二層膜におけるリガンド長修飾

Ligand-Length Modification in CsPbBr Perovskite Nanocrystals and Bilayers with PbS Quantum Dots for Improved Photodetection Performance.
  • Juan Navarro Arenas
  • Ananthakumar Soosaimanickam
  • Hamid Pashaei Adl
  • Rafael Abargues
  • Pablo P Boix
  • Pedro J Rodríguez-Cantó
  • Juan P Martínez-Pastor
  • Nanomaterials (Basel).2020 Jul;10(7). E1297. doi: 10.3390/nano10071297.Epub 2020-07-02.

急性骨髄性白血病患者におけるカルバペネム非感受性グラム陰性桿菌血症のリスク因子と臨床転帰

Risk factors for and clinical outcomes of carbapenem non-susceptible gram negative bacilli bacteremia in patients with acute myelogenous leukemia.
  • Dong Hoon Shin
  • Dong-Yeop Shin
  • Chang Kyung Kang
  • Suhyeon Park
  • Jieun Park
  • Kang Il Jun
  • Taek Soo Kim
  • Youngil Koh
  • Jun Shik Hong
  • Pyoeng Gyun Choe
  • Wan Beom Park
  • Nam-Joong Kim
  • Sung-Soo Yoon
  • Inho Kim
  • Myoung-Don Oh
  • BMC Infect. Dis..2020 Jun;20(1):404. 10.1186/s12879-020-05131-2. doi: 10.1186/s12879-020-05131-2.Epub 2020-06-09.

European confederation of medical mycology expert consult-AN ECMM excellence center initiative

European confederation of medical mycology expert consult-An ECMM excellence center initiative.
  • Philipp Koehler
  • Blandine Denis
  • David W Denning
  • Jean-Pierre Gangneux
  • Martin Hoenigl
  • Dimitrios P Kontoyiannis
  • Robert Krause
  • Katrien Lagrou
  • Cornelia Lass-Flörl
  • Johan Maertens
  • Ivana Mareković
  • Jacques F Meis
  • Jean-Michel Molina
  • Sanja Pleško
  • Juergen Prattes
  • Peter-Michael Rath
  • Riina Rautemaa-Richardson
  • Malcolm Richardson
  • Esther Segal
  • Danila Seidel
  • Isabel Spriet
  • Joerg Steinmann
  • Paul E Verweij
  • Oliver A Cornely
  • Mycoses.2020 Jun;63(6):566-572. doi: 10.1111/myc.13076.Epub 2020-04-13.

プロテアソーム活性化因子であるPA200は、神経芽腫細胞においてミトコンドリアを選択的に阻害すると、細胞生存に関わる遺伝子の発現を制御する

The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells.
  • Abdennour Douida
  • Frank Batista
  • Agnieszka Robaszkiewicz
  • Pal Boto
  • Azzam Aladdin
  • Mónika Szenykiv
  • Rita Czinege
  • László Virág
  • Krisztina Tar
  • J. Cell. Mol. Med..2020 Jun;24(12):6716-6730. doi: 10.1111/jcmm.15323.Epub 2020-05-05.

アマゾン中流域を旅していると、ブラジルのリオ・ゼング盆地に生息する新種の装甲ナマズ、Aspidoras azaghal (Siluriformes: Callichthyidae)が発見されました

A journey through the Amazon Middle Earth reveals Aspidoras azaghal (Siluriformes: Callichthyidae), a new species of armored catfish from the rio Xingu basin, Brazil.
  • Luiz F C Tencatt
  • Janice Muriel-Cunha
  • Jansen Zuanon
  • Marlon F C Ferreira
  • Marcelo R Britto
  • J. Fish Biol..2020 Jul;doi: 10.1111/jfb.14467.Epub 2020-07-16.

Ezh2依存性H3K27me3修飾は、骨芽細胞におけるCYP24A1遺伝子発現のビタミンD3依存性エピジェネティック制御を動的に制御することを明らかにした

Ezh2-dependent H3K27me3 modification dynamically regulates vitamin D3-dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells.
  • Daniel Moena
  • Gino Nardocci
  • Elvis Acevedo
  • Jane Lian
  • Gary Stein
  • Janet Stein
  • Martin Montecino
  • J. Cell. Physiol..2020 Jun;235(6):5404-5412. doi: 10.1002/jcp.29428.Epub 2020-01-07.

ゴールドシール(Hydrastis canadensis L.)とその活性成分:その有効性と毒性の問題の批判的なレビュー

Goldenseal (Hydrastis canadensis L.) and its active constituents: a critical review of their efficacy and toxicological issues.
  • Sudip Kumar Mandal
  • Amal Kumar Maji
  • Siddhartha Kumar Mishra
  • Pir Mohammad Ishfaq
  • Hari Prashed Devkota
  • Ana Sanches Silva
  • Niranjan Das
  • Pharmacol. Res..2020 Jul;:105085. S1043-6618(20)31393-1. doi: 10.1016/j.phrs.2020.105085.Epub 2020-07-16.

ワイナリー副産物であるブドウの種子の親油性抗酸化物質の持続可能な供給源としての革新的な価値化と従来の価値化

Innovative and Conventional Valorizations of Grape Seeds from Winery By-Products as Sustainable Source of Lipophilic Antioxidants.
  • Ivana Dimić
  • Nemanja Teslić
  • Predrag Putnik
  • Danijela Bursać Kovačević
  • Zoran Zeković
  • Branislav Šojić
  • Živan Mrkonjić
  • Dušica Čolović
  • Domenico Montesano
  • Branimir Pavlić
  • Antioxidants (Basel).2020 Jul;9(7). E568. doi: 10.3390/antiox9070568.Epub 2020-07-01.

薬剤抵抗性局所てんかんにおけるペランパネルの併用療法としての有効性を"実世界"で検討:側頭葉てんかんを中心に

The efficacy of perampanel as adjunctive therapy in drug-resistant focal epilepsy in a "real world" context: focus on temporal lobe epilepsy.
  • Angelo Pascarella
  • Luigi Francesco Iannone
  • Giancarlo Di Gennaro
  • Alfredo D'Aniello
  • Edoardo Ferlazzo
  • Nazareno Gagliostro
  • Francesco Ursini
  • Paolo Bonanni
  • Nicola Paciello
  • Andrea Romigi
  • Umberto Aguglia
  • Giovambattista De Sarro
  • Emilio Russo
  • Antonio Gambardella
  • Angelo Labate
  • J. Neurol. Sci..2020 Aug;415:116903. S0022-510X(20)30240-9. doi: 10.1016/j.jns.2020.116903.Epub 2020-05-15.

イソベンゾナフラノンとオイゲノールとインダン-1,3-ジオンのトリアゾリック誘導体を足場とした新規な西ナイルウイルスプロテアーゼ阻害剤の発見

Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds.
  • André S de Oliveira
  • Poliana A R Gazolla
  • Ana Flávia C da S Oliveira
  • Wagner L Pereira
  • Lívia C de S Viol
  • Angélica F da S Maia
  • Edjon G Santos
  • Ítalo E P da Silva
  • Tiago A de Oliveira Mendes
  • Adalberto M da Silva
  • Roberto S Dias
  • Cynthia C da Silva
  • Marcelo D Polêto
  • Róbson R Teixeira
  • Sergio O de Paula
  • PLoS ONE.2019;14(9):e0223017. PONE-D-19-08554. doi: 10.1371/journal.pone.0223017.Epub 2019-09-26.

コントラスト増強磁気共鳴イメージングにより、アストロサイト・アクアポリン-4水チャネルが糖質流入と間質性溶質輸送に果たす役割の証拠が得られた

Contrast-enhanced magnetic resonance imaging evidence for the role of astrocytic aquaporin-4 water channels in glymphatic influx and interstitial solute transport.
  • Kazuki Takano
  • Masayuki Yamada
  • Magn Reson Imaging.2020 May;71:11-16. S0730-725X(19)30694-0. doi: 10.1016/j.mri.2020.05.001.Epub 2020-05-20.

猛禽類における汚染物質モニタリングのための概略的なサンプリングプロトコル

A schematic sampling protocol for contaminant monitoring in raptors.
  • Silvia Espín
  • Jovan Andevski
  • Guy Duke
  • Igor Eulaers
  • Pilar Gómez-Ramírez
  • Gunnar Thor Hallgrimsson
  • Björn Helander
  • Dorte Herzke
  • Veerle L B Jaspers
  • Oliver Krone
  • Rui Lourenço
  • Pedro María-Mojica
  • Emma Martínez-López
  • Rafael Mateo
  • Paola Movalli
  • Pablo Sánchez-Virosta
  • Richard F Shore
  • Christian Sonne
  • Nico W van den Brink
  • Bert van Hattum
  • Al Vrezec
  • Chris Wernham
  • Antonio J García-Fernández
  • Ambio.2020 May;10.1007/s13280-020-01341-9. doi: 10.1007/s13280-020-01341-9.Epub 2020-05-12.

オートファジー阻害は、トランスフォーミング成長因子β(TGF-β)によって誘導されるG1停止に腎尿細管上皮細胞を感作する

Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-β).
  • Chen Yang
  • Hong-Luan Wu
  • Zhi-Hang Li
  • Xiao-Cui Chen
  • Hong-Yong Su
  • Xiao-Yan Guo
  • Ning An
  • Kai-Peng Jing
  • Qing-Jun Pan
  • Hua-Feng Liu
  • Med. Sci. Monit..2020 Jun;26:e922673. 922673. doi: 10.12659/MSM.922673.Epub 2020-06-07.

相分離(OOPS)を用いたRNA結合型プロテオームとタンパク質結合型トランスクリプトームの効率的な回収

Efficient recovery of the RNA-bound proteome and protein-bound transcriptome using phase separation (OOPS).
  • Eneko Villanueva
  • Tom Smith
  • Rayner M L Queiroz
  • Mie Monti
  • Mariavittoria Pizzinga
  • Mohamed Elzek
  • Veronica Dezi
  • Robert F Harvey
  • Manasa Ramakrishna
  • Anne E Willis
  • Kathryn S Lilley
  • Nat Protoc.2020 Jul;10.1038/s41596-020-0344-2. doi: 10.1038/s41596-020-0344-2.Epub 2020-07-10.

トリプルネガティブ乳がん細胞における抗増殖遺伝子B細胞転座遺伝子2によるTwist1発現のトランスレーショナルダウンレギュレーション

Translational downregulation of Twist1 expression by antiproliferative gene, B-cell translocation gene 2, in the triple negative breast cancer cells.
  • Preethi Devanand
  • Santhoshkumar Sundaramoorthy
  • Min Sook Ryu
  • Aravinth Kumar Jayabalan
  • Takbum Ohn
  • In Kyoung Lim
  • Cell Death Dis.2019 05;10(6):410. 10.1038/s41419-019-1640-z. doi: 10.1038/s41419-019-1640-z.Epub 2019-05-28.

減衰全反射-フーリエ変換赤外分光法とケモメトリクスによるヘロイン、メタンフェタミン、ケタミンおよびそれらの添加物の分類

Classification of heroin, methamphetamine, ketamine and their additives by attenuated total reflection-Fourier transform infrared spectroscopy and chemometrics.
  • Xinlong He
  • Jifen Wang
  • Xinwei You
  • Fan Niu
  • Linyuan Fan
  • Yufan Lv
  • Spectrochim Acta A Mol Biomol Spectrosc.2020 Jul;241:118665. S1386-1425(20)30644-2. doi: 10.1016/j.saa.2020.118665.Epub 2020-07-11.

強力な抗ライシュマニア活性を有する8-ヒドロキシナフチリジンの同定と最適化。初期SARと活性の評価

Identification and optimisation of a series of 8-hydroxy naphthyridines with potent antileishmanial activity: Initial SAR and assessment of activity.
  • Michael Thomas
  • Manu De Rycker
  • Richard J Wall
  • Daniel Spinks
  • Ola Epemolu
  • Sujatha Manthri
  • Suzanne Norval
  • Maria Osuna-Cabello
  • Stephen Patterson
  • Jennifer Riley
  • Frederick R C Simeons
  • Laste Stojanovski
  • John Thomas
  • Stephen Thompson
  • Claire Naylor
  • Jose M Fiandor
  • Paul G Wyatt
  • Maria Marco
  • Susan Wyllie
  • Kevin D Read
  • Timothy J Miles
  • Ian H Gilbert
  • J. Med. Chem..2020 Jul;doi: 10.1021/acs.jmedchem.0c00705.Epub 2020-07-14.

S100A9は、TLR4/TNF経路を介して帯状疱疹神経痛のマウスモデルにおいて重要な役割を果たしています

S100A9 plays a pivotal role in a mouse model of herpetic neuralgia via TLR4/TNF pathway.
  • Cássia R Silva
  • Bruno M S Melo
  • Jaqueline R Silva
  • Alexandre H Lopes
  • Janaina A Pereira
  • Nerry T Cecilio
  • Jonilson Berlink
  • Giovani G Souza
  • Guilherme Lucas
  • Thomas Vogl
  • Fernando Q Cunha
  • José C Alves-Filho
  • Thiago M Cunha
  • Brain Behav. Immun..2020 Mar;S0889-1591(19)31492-8. doi: 10.1016/j.bbi.2020.03.033.Epub 2020-03-31.

副甲状腺ホルモン、1.25(OH)D、および線維芽細胞増殖因子 23 が産卵鶏のさまざまな組織におけるカルシウム代謝を制御する遺伝子に及ぼす可能性のある役割

Possible roles of parathyroid hormone, 1.25(OH)D, and fibroblast growth factor 23 on genes controlling calcium metabolism across different tissues of the laying hen.
  • A Gloux
  • N Le Roy
  • J Ezagal
  • N Même
  • C Hennequet-Antier
  • M L Piketty
  • D Prié
  • G Benzoni
  • J Gautron
  • Y Nys
  • A Narcy
  • M J Duclos
  • Domest. Anim. Endocrinol..2020 Jul;72:106407. S0739-7240(19)30086-4. doi: 10.1016/j.domaniend.2019.106407.Epub 2019-10-23.

パラス女性における骨盤底筋と尿失禁の治療に対する高強度集束電磁技術と電気刺激の効果に関する比較研究。治療後のデータの分析

A Comparative Study on the Effects of High-Intensity Focused Electromagnetic Technology and Electrostimulation for the Treatment of Pelvic Floor Muscles and Urinary Incontinence in Parous Women: Analysis of Posttreatment Data.
  • Elena Silantyeva
  • Dragana Zarkovic
  • Evgeniia Astafeva
  • Ramina Soldatskaia
  • Mekan Orazov
  • Marina Belkovskaya
  • Mark Kurtser
  • Female Pelvic Med Reconstr Surg.2020 Jan;doi: 10.1097/SPV.0000000000000807.Epub 2020-01-25.

血小板が豊富な血漿(PRP)は、血管新生とコラーゲン合成を促進することで、マウスの膝蓋腱の治癒を促進します

Platelet-rich plasma (PRP) accelerates murine patellar tendon healing through enhancement of angiogenesis and collagen synthesis.
  • Yohei Kobayashi
  • Yoshitomo Saita
  • Tomoiku Takaku
  • Tomomasa Yokomizo
  • Hirofumi Nishio
  • Hiroshi Ikeda
  • Yuji Takazawa
  • Masashi Nagao
  • Kazuo Kaneko
  • Norio Komatsu
  • J Exp Orthop.2020 Jul;7(1):49. 10.1186/s40634-020-00267-1. doi: 10.1186/s40634-020-00267-1.Epub 2020-07-08.

ドイツ領北海(北海)の一般的な洋上風力発電所の基礎に生息する移動性海底メガファウナ - 展開から2年後、Cancer pagurusの生産量が増加している

Mobile demersal megafauna at common offshore wind turbine foundations in the German Bight (North Sea) two years after deployment - increased production rate of Cancer pagurus.
  • R Krone
  • G Dederer
  • P Kanstinger
  • P Krämer
  • C Schneider
  • I Schmalenbach
  • Mar. Environ. Res..2017 Feb;123:53-61. S0141-1136(16)30301-4. doi: 10.1016/j.marenvres.2016.11.011.Epub 2016-11-29.

p21 の過剰発現は、細胞周期制御を介して CD43+細胞の生成を阻害することで、ヒト造血に抑制効果がある

Overexpression of p21 Has Inhibitory Effect on Human Hematopoiesis by Blocking Generation of CD43+ Cells via Cell-Cycle Regulation.
  • Jiahui Zeng
  • Huifang Zhang
  • Yuanling Liu
  • Wencui Sun
  • Danying Yi
  • Lijiao Zhu
  • Yonggang Zhang
  • Xu Pan
  • Yijing Chen
  • Ya Zhou
  • Guohui Bian
  • Mowen Lai
  • Qiongxiu Zhou
  • Jiaxin Liu
  • Bo Chen
  • Feng Ma
  • Int J Stem Cells.2020 Jul;13(2):202-211. ijsc20033. doi: 10.15283/ijsc20033.

バキュロウイルス蛋白質発現系を用いた生きた昆虫細胞の蛋白質の高分解能異核多次元NMR

High-resolution heteronuclear multidimensional NMR of proteins in living insect cells using a baculovirus protein expression system.
  • Jumpei Hamatsu
  • Daniel O'Donovan
  • Takashi Tanaka
  • Takahiro Shirai
  • Yuichiro Hourai
  • Tsutomu Mikawa
  • Teppei Ikeya
  • Masaki Mishima
  • Wayne Boucher
  • Brian O Smith
  • Ernest D Laue
  • Masahiro Shirakawa
  • Yutaka Ito
  • J. Am. Chem. Soc..2013 Feb;135(5):1688-91. doi: 10.1021/ja310928u.Epub 2013-01-27.

DNA複製タンパク質Cdc45は、Leishmania donovaniのPIPボックスを介してPCNAと直接相互作用し、Cdc45のPIPボックスは細胞の生存に不可欠である

DNA replication protein Cdc45 directly interacts with PCNA via its PIP box in Leishmania donovani and the Cdc45 PIP box is essential for cell survival.
  • Aarti Yadav
  • Varshni Sharma
  • Jyoti Pal
  • Pallavi Gulati
  • Manisha Goel
  • Udita Chandra
  • Neha Bansal
  • Swati Saha
  • PLoS Pathog..2020 05;16(5):e1008190. PPATHOGENS-D-19-02030. doi: 10.1371/journal.ppat.1008190.Epub 2020-05-15.

良性家族性乳児性痙攣:2q24番染色体上の新規遺伝子座のマッピングと遺伝的異質性の証拠

Benign familial infantile convulsions: mapping of a novel locus on chromosome 2q24 and evidence for genetic heterogeneity.
  • M Malacarne
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  • F Madia
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  • B dalla Bernardina
  • A Bianchi
  • P Bonanni
  • P De Marco
  • A Gambardella
  • L Giordano
  • M L Lispi
  • A Romeo
  • E Santorum
  • F Vanadia
  • M Vecchi
  • P Veggiotti
  • F Vigevano
  • F Viri
  • F D Bricarelli
  • F Zara
  • Am. J. Hum. Genet..2001 Jun;68(6):1521-6. S0002-9297(07)61064-7. doi: 10.1086/320596.Epub 2001-04-20.

開口緑内障および眼圧亢進症に対するビマトプロストインプラントの第3相無作為化20ヵ月間試験(ARTEMIS 1)

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).
  • Felipe A Medeiros
  • Thomas R Walters
  • Miriam Kolko
  • Michael Coote
  • Marina Bejanian
  • Margot L Goodkin
  • Qiang Guo
  • Jane Zhang
  • Michael R Robinson
  • Robert N Weinreb
  • Ophthalmology.2020 Jun;S0161-6420(20)30555-8. doi: 10.1016/j.ophtha.2020.06.018.Epub 2020-06-13.

数学的に導かれたアプローチを用いて、マウスモデルにおけるキメラ抗原受容体T細胞の投与数を減少させる

Less is more: reducing the number of administered chimeric antigen receptor T cells in a mouse model using a mathematically guided approach.
  • Anat Globerson Levin
  • Natalie Kronik
  • Tamar Shiloach
  • Tova Waks
  • Zelig Eshhar
  • Vladimir Vainstein
  • Cancer Immunol. Immunother..2020 Jul;69(7):1165-1175. 10.1007/s00262-020-02516-9. doi: 10.1007/s00262-020-02516-9.Epub 2020-03-04.

LQFM126プロトタイプのB16F10メラノーマ細胞に対する抗血管新生・抗腫瘍活性

Antiangiogenic and antitumoral activity of LQFM126 prototype against B16F10 melanoma cells.
  • Artur Christian Garcia da Silva
  • Bruna Dos Santos Rodrigues
  • Wanessa Machado Andrade
  • Thaís Rosa Marques Dos Santos
  • Flávio Silva de Carvalho
  • Germán Sanz
  • Boniek G Vaz
  • Luciano M Lião
  • Ricardo Menegatti
  • Marize Campos Valadares
  • Chem. Biol. Interact..2020 Jul;325:109127. S0009-2797(20)30404-X. doi: 10.1016/j.cbi.2020.109127.Epub 2020-05-11.