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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

米国のHIV臨床医を対象とした全国調査。Affordable Care Actについての知識と態度、およびケアの質とケアへの障壁への影響に関する意見

National Survey of US HIV Clinicians: Knowledge and Attitudes About the Affordable Care Act and Opinions of its Impact on Quality of Care and Barriers to Care.
  • Kathleen A McManus
  • Joshua Ferey
  • Elizabeth Farrell
  • Rebecca Dillingham
  • Open Forum Infect Dis.2020 Jul;7(7):ofaa225. ofaa225. doi: 10.1093/ofid/ofaa225.Epub 2020-06-10.

細胞質アスコルビン酸ペルオキシダーゼ1は、窒素欠乏ストレス下の茶植物において、窒素調節タンパク質P-IIと協働してアスコルビン酸代謝を調節する

Cytosolic ascorbate peroxidase 1 modulates ascorbic acid metabolism through cooperating with nitrogen regulatory protein P-II in tea plant under nitrogen deficiency stress.
  • Hui Li
  • Hao Liu
  • Yu Wang
  • Rui-Min Teng
  • Jingyu Liu
  • Shijia Lin
  • Jing Zhuang
  • Genomics.2020 Sep;112(5):3497-3503. S0888-7543(20)30459-6. doi: 10.1016/j.ygeno.2020.06.025.Epub 2020-06-17.

胃癌手術におけるプロポフォールを用いた全静脈内麻酔はデスフルラン麻酔と比較して生存率を向上させる。レトロスペクティブな分析

Propofol-based total intravenous anesthesia improves survival compared to desflurane anesthesia in gastric cancer surgery: A retrospective analysis.
  • Nian-Cih Huang
  • Meei-Shyuan Lee
  • Hou-Chuan Lai
  • Han-Ting Lin
  • Yi-Hsuan Huang
  • Chueng-He Lu
  • Chen-Heng Hsu
  • Zhi-Fu Wu
  • Medicine (Baltimore).2020 Jun;99(25):e20714. 00005792-202006190-00055. doi: 10.1097/MD.0000000000020714.

高ニコチンではあるが低ニコチンではないタバコの煙に曝露すると、雄ラットでは依存性の兆候が見られ、雌ラットではニコチンの効果が増強される

Exposure to smoke from high- but not low-nicotine cigarettes leads to signs of dependence in male rats and potentiates the effects of nicotine in female rats.
  • Ranjithkumar Chellian
  • Azin Behnood-Rod
  • Ryann Wilson
  • Isaac Wilks
  • Parker Knight
  • Marcelo Febo
  • Adriaan W Bruijnzeel
  • Pharmacol. Biochem. Behav..2020 Jul;:172998. S0091-3057(20)30226-4. doi: 10.1016/j.pbb.2020.172998.Epub 2020-07-15.

縫合プルスルー法を用いたデスメットストリッピング自動内皮角化術で管理したピアソン骨髄膵症候群児の内皮機能障害

Endothelial dysfunction in a child with Pearson marrow-pancreas syndrome managed with Descemet stripping automated endothelial keratoplasty using a suture pull-through technique.
  • Raghav Vadhul
  • Caroline S Halbach
  • Raymond G Areaux
  • Susan Berry
  • Joshua H Hou
  • Digit J Ophthalmol.2019 Apr;25(4):59-64. djo-19-040. doi: 10.5693/djo.02.2019.09.001.Epub 2019-11-17.

長期交互絶食はガービル海馬においてインターロイキン-13を増加させるが、虚血-再灌流障害からのBBBと錐体細胞の保護には至らない

Long-Term Alternating Fasting Increases Interleukin-13 in the Gerbil Hippocampus, But Does Not Protect BBB and Pyramidal Neurons From Ischemia-Reperfusion Injury.
  • Tae-Kyeong Lee
  • Yoonsoo Park
  • Bora Kim
  • Jae-Chul Lee
  • Myoung Cheol Shin
  • Taek Geun Ohk
  • Chan Woo Park
  • Jun Hwi Cho
  • Joon Ha Park
  • Choong Hyun Lee
  • Moo-Ho Won
  • Ji Hyeon Ahn
  • Neurochem. Res..2020 Jul;10.1007/s11064-020-03094-z. doi: 10.1007/s11064-020-03094-z.Epub 2020-07-15.

合成オキシトシンペプチドに対するモノクローナル抗体がマウス視床下部神経細胞を染色する

A monoclonal antibody raised against a synthetic oxytocin peptide stains mouse hypothalamic neurones.
  • Yuji Kogami
  • Takahiro Tsuji
  • Chiharu Tsuji
  • Shigeru Yokoyama
  • Kazumi Furuhara
  • Olga Lopatina
  • Anna Shabalova
  • Alla B Salmina
  • Yumi Watanabe
  • Tsuyoshi Hattori
  • Katsuhiko Nishimori
  • Kota Kodama
  • Haruhiro Higashida
  • J. Neuroendocrinol..2020 Apr;32(4):e12815. doi: 10.1111/jne.12815.Epub 2020-02-11.

電話による心理学的介入を提供するための実務家の準備に影響を与えるものは何か?理論領域フレームワークを用いた行動変容の質的研究

What influences practitioners' readiness to deliver psychological interventions by telephone? A qualitative study of behaviour change using the Theoretical Domains Framework.
  • Cintia L Faija
  • Janice Connell
  • Charlotte Welsh
  • Kerry Ardern
  • Elinor Hopkin
  • Judith Gellatly
  • Kelly Rushton
  • Claire Fraser
  • Annie Irvine
  • Christopher J Armitage
  • Paul Wilson
  • Peter Bower
  • Karina Lovell
  • Penny Bee
  • BMC Psychiatry.2020 Jul;20(1):371. 10.1186/s12888-020-02761-3. doi: 10.1186/s12888-020-02761-3.Epub 2020-07-16.

肺炎球菌と上皮との相互作用に関与する分子経路の重要な制御が時間分解mRNAおよびmiRNAの発現プロファイリングによって明らかになった

Time-resolved mRNA and miRNA expression profiling reveals crucial coregulation of molecular pathways involved in epithelial-pneumococcal interactions.
  • Haiyan Li
  • Li Lin
  • Lei Chong
  • Shuge Gu
  • Shunhang Wen
  • Gang Yu
  • Xiaoguang Hu
  • Lin Dong
  • Hailin Zhang
  • Changchong Li
  • Immunol. Cell Biol..2020 Jun;doi: 10.1111/imcb.12371.Epub 2020-06-27.

カルシウム値が正常な人の血清カルシウム、骨密度、骨折リスクの上昇に対する遺伝的素因:メンデル無作為化研究

Genetic predisposition to increased serum calcium, bone mineral density, and fracture risk in individuals with normal calcium levels: mendelian randomisation study.
  • Agustin Cerani
  • Sirui Zhou
  • Vincenzo Forgetta
  • John A Morris
  • Katerina Trajanoska
  • Fernando Rivadeneira
  • Susanna C Larsson
  • Karl Michaëlsson
  • J Brent Richards
  • BMJ.2019 08;366:l4410. doi: 10.1136/bmj.l4410.Epub 2019-08-01.

miRNA-146aの欠失はミクログリアの機能とプロテオームを分化的に変化させる

Absence of miRNA-146a Differentially Alters Microglia Function and Proteome.
  • Nellie A Martin
  • Kirsten H Hyrlov
  • Maria L Elkjaer
  • Eva K Thygesen
  • Agnieszka Wlodarczyk
  • Kirstine J Elbaek
  • Christopher Aboo
  • Justyna Okarmus
  • Eirikur Benedikz
  • Richard Reynolds
  • Zoltan Hegedus
  • Allan Stensballe
  • Åsa Fex Svenningsen
  • Trevor Owens
  • Zsolt Illes
  • Front Immunol.2020;11:1110. doi: 10.3389/fimmu.2020.01110.Epub 2020-06-05.

第四級アンモニウム化合物の人体への影響評価塩化ジデシルジメチルアンモニウムおよびアルキル(C12-C16)ジメチルベンジルアンモニウム

Human health hazard assessment of quaternary ammonium compounds: Didecyl dimethyl ammonium chloride and alkyl (C12-C16) dimethyl benzyl ammonium chloride.
  • Anthony Luz
  • Paul DeLeo
  • Nathan Pechacek
  • Mike Freemantle
  • Regul. Toxicol. Pharmacol..2020 Jul;:104717. S0273-2300(20)30143-4. doi: 10.1016/j.yrtph.2020.104717.Epub 2020-07-05.

交感神経系活動のマーカーは、メタボリックシンドロームの被験者の複雑な血漿脂質と関連している

Markers of sympathetic nervous system activity associate with complex plasma lipids in metabolic syndrome subjects.
  • Paul J Nestel
  • Anmar A Khan
  • Nora E Straznicky
  • Natalie A Mellett
  • Kaushala Jayawardana
  • Piyushkumar A Mundra
  • Gavin W Lambert
  • Peter J Meikle
  • Atherosclerosis.2017 01;256:21-28. S0021-9150(16)31520-9. doi: 10.1016/j.atherosclerosis.2016.11.032.Epub 2016-12-01.

シスタチン C およびクレアチニンベースの推定 GFR と虚弱性および有害転帰との関連性の違い。収縮期血圧介入試験(SPRINT)のコホート解析

The Difference Between Cystatin C- and Creatinine-Based Estimated GFR and Associations With Frailty and Adverse Outcomes: A Cohort Analysis of the Systolic Blood Pressure Intervention Trial (SPRINT).
  • O Alison Potok
  • Joachim H Ix
  • Michael G Shlipak
  • Ronit Katz D Phil
  • Amret T Hawfield
  • Michael V Rocco
  • Walter T Ambrosius
  • Monique E Cho
  • Nicholas M Pajewski
  • Anjay Rastogi
  • Dena E Rifkin
  • Am. J. Kidney Dis..2020 Jul;S0272-6386(20)30787-3. doi: 10.1053/j.ajkd.2020.05.017.Epub 2020-07-12.

ヒトアデノウイルス19型に対する抗ウイルス剤の評価にヒトリンパ球を応用:ザルシタビンはシドフォビルと比較して優れた活性を示す

Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir.
  • Kohsuke Nakagawara
  • Hironori Hayashi
  • Kumi Kawaji
  • Mina Sasano
  • Eiichi N Kodama
  • Antivir. Chem. Chemother..2020 Jan-Dec;28:2040206620921319. doi: 10.1177/2040206620921319.

最大4種のトリコモナスウイルス(Family Totiviridae)の株に同時感染したトリコモナス膣炎の臨床分離株

Clinical isolates of Trichomonas vaginalis concurrently infected by strains of up to four Trichomonasvirus species (Family Totiviridae).
  • Russell P Goodman
  • Taylor S Freret
  • Tomasz Kula
  • Alexander M Geller
  • Megan W T Talkington
  • Vanessa Tang-Fernandez
  • Olimpia Suciu
  • Aleksander A Demidenko
  • Said A Ghabrial
  • David H Beach
  • Bibhuti N Singh
  • Raina N Fichorova
  • Max L Nibert
  • J. Virol..2011 May;85(9):4258-70. JVI.00220-11. doi: 10.1128/JVI.00220-11.Epub 2011-02-23.

予測不可能なストレスや社会的孤立を繰り返すことで、慢性的なHPA軸機能障害や持続的な異常恐怖記憶が誘発される

Repeated unpredictable stress and social isolation induce chronic HPA axis dysfunction and persistent abnormal fear memory.
  • Moustafa Algamal
  • Andrew J Pearson
  • Coral Hahn-Townsend
  • Ioana Burca
  • Michael Mullan
  • Fiona Crawford
  • Joseph O Ojo
  • Prog. Neuropsychopharmacol. Biol. Psychiatry.2020 Jul;:110035. S0278-5846(20)30351-1. doi: 10.1016/j.pnpbp.2020.110035.Epub 2020-07-16.

重度の膣出血に対して2回の子宮動脈塞栓術を行った後、化学療法および放射線治療抵抗性の局所進行子宮頸部癌患者における閉塞神経損傷の1例。症例報告と文献のレビュー

Obturator nerve injury in a chemo and radio-resistant patient with a locally-advanced cervical cancer after two previous uterine artery embolizations for severe vaginal bleeding: Case report and review of literature.
  • Raffaele Tinelli
  • Stefano Uccella
  • Luigi Nappi
  • Giuseppe D'Amato
  • Ettore Cicinelli
  • Stefano Angioni
  • Eur. J. Obstet. Gynecol. Reprod. Biol..2020 Jul;252:355-358. S0301-2115(20)30442-5. doi: 10.1016/j.ejogrb.2020.07.002.Epub 2020-07-02.

中国人血液ドナーにおける C 型肝炎ウイルスの遺伝子型/サブタイプの分布と進化。最近のウイルスの拡大を明らかにする

Hepatitis C virus genotype/subtype distribution and evolution among Chinese blood donors: Revealing recent viral expansion.
  • Yu Zhang
  • Zhan Gao
  • Shaoli Wang
  • Jing Liu
  • Ness Paul
  • Tao He
  • Cunxu Liu
  • Hongbin Zhang
  • Yunlai Lv
  • Ru'an Cao
  • Wei Mao
  • Jianhua Wan
  • Hongli Ma
  • Mei Huang
  • Yu Liu
  • Jingxing Wang
  • Pu Liao
  • Peibin Zeng
  • Miao He
  • Hua Shan
  • PLoS ONE.2020;15(7):e0235612. PONE-D-19-35851. doi: 10.1371/journal.pone.0235612.Epub 2020-07-10.

腰椎椎間板の高速T2マッピング。臨床的に実現可能な取得時間でのロバストなT2緩和時間測定のための高度にアンサンプル化されたK空間データ

Accelerated T2 Mapping of the Lumbar Intervertebral Disc: Highly Undersampled K-Space Data for Robust T2 Relaxation Time Measurement in Clinically Feasible Acquisition Times.
  • Marcus Raudner
  • Markus Schreiner
  • Tom Hilbert
  • Tobias Kober
  • Michael Weber
  • Reinhard Windhager
  • Siegfried Trattnig
  • Vladimir Juras
  • Invest Radiol.2020 Jul;doi: 10.1097/RLI.0000000000000690.Epub 2020-07-08.

インド南西部沿岸の農業地帯、沿岸部、背水部における表土中の有機塩素系農薬の空間的分布と組成のプロファイル

Spatial distribution and compositional profiles of organochlorine pesticides in the surface soil from the agricultural, coastal and backwater transects along the south-west coast of India.
  • Sanjenbam Nirmala Khuman
  • P G Vinod
  • Girija Bharat
  • Y S Mohana Kumar
  • Paromita Chakraborty
  • Chemosphere.2020 Sep;254:126699. S0045-6535(20)30892-4. doi: 10.1016/j.chemosphere.2020.126699.Epub 2020-04-07.

食品および微生物由来の代謝物のマルチターゲットメタボロミクスによる栄養と健康のクロストークにおけるヒトの食事の定量化

Quantifying the human diet in the crosstalk between nutrition and health by multi-targeted metabolomics of food and microbiota-derived metabolites.
  • Raúl González-Domínguez
  • Olga Jáuregui
  • Pedro Mena
  • Kati Hanhineva
  • Francisco José Tinahones
  • Donato Angelino
  • Cristina Andrés-Lacueva
  • Int J Obes (Lond).2020 Jun;10.1038/s41366-020-0628-1. doi: 10.1038/s41366-020-0628-1.Epub 2020-06-15.

エピジェネティックな調節とPD-1/PD-L1遮断を組み合わせることで、食道癌に対するMAGE-A11抗原特異的CD8+T細胞をベースとした免疫療法が強化された

Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma.
  • Yunyan Wu
  • Meixiang Sang
  • Fei Liu
  • Jiandong Zhang
  • Weijing Li
  • Zhenhua Li
  • Lina Gu
  • Yang Zheng
  • Juan Li
  • Baoen Shan
  • Carcinogenesis.2020 Jul;41(7):894-903. 5856317. doi: 10.1093/carcin/bgaa057.

急性タンデム頸動脈閉塞症における血管内治療の有効性と安全性。単一施設コホートの分析

Efficacy and Safety of Endovascular Treatment in Acute Tandem Carotid Occlusions: Analysis of a Single-Center Cohort.
  • Santiago Fernández Menéndez
  • Eduardo Murias Quintana
  • Pedro Vega Valdés
  • Edison Morales Deza
  • Elena López-Cancio
  • Lorena Benavente Fernández
  • Montserrat González Delgado
  • Maria Rico-Santos
  • Sergio Calleja Puerta
  • Davinia Larrosa Campo
  • Cerebrovasc Dis Extra.2020 Jun;10(2):50-58. 000507919. doi: 10.1159/000507919.Epub 2020-06-24.

UPLC-Q-TOF/MSを用いた血漿メタボローム解析により、ルイス腫瘍担持マウスの非小細胞肺癌に対する化合物Kushen注射による介入のメカニズムを明らかにした

A UPLC-Q-TOF/MS-based plasma metabolomics approach reveals the mechanism of Compound Kushen Injection-based intervention against non-small cell lung cancer in Lewis tumor-bearing mice.
  • Huan Wu
  • Lina Wang
  • Xiang Zhan
  • Bin Wang
  • Jiawen Wu
  • An Zhou
  • Phytomedicine.2020 Jun;76:153259. S0944-7113(20)30090-8. doi: 10.1016/j.phymed.2020.153259.Epub 2020-06-02.

HCT-15誘発大腸直腸腫瘍異種移植片におけるEGFR陽性腫瘍診断のためのインジウムキレートセツキシマブのSPECTイメージング評価

SPECT imaging evaluation of indium-chelated cetuximab for diagnosing EGFR-positive tumor in an HCT-15-induced colorectal xenograft.
  • Bin-Bin Shih
  • Yi-Fang Chang
  • Chun-Chia Cheng
  • Hao-Jhih Yang
  • Kang-Wei Chang
  • Ai-Sheng Ho
  • Hua-Ching Lin
  • Chun Yeh
  • Chun-Chao Chang
  • J Chin Med Assoc.2017 Dec;80(12):766-773. S1726-4901(17)30232-0. doi: 10.1016/j.jcma.2017.02.010.Epub 2017-09-29.

CINRGベッカー自然史研究。ベースラインの特徴

The CINRG Becker Natural History Study: Baseline Characteristics.
  • Paula R Clemens
  • Gabriela Niizawa
  • Jia Feng
  • Julaine Florence
  • Andrea Smith D'Alessandro
  • Lauren P Morgenroth
  • Ksenija Gorni
  • Michela Guglieri
  • Anne Connolly
  • Matthew Wicklund
  • Tulio Bertorini
  • Jean K Mah
  • Mathula Thangarajh
  • Edward Smith
  • Nancy Kuntz
  • Craig M McDonald
  • Erik K Henricson
  • Saila Upadhyayula
  • Barry Byrne
  • Georgios Manousakis
  • Amy Harper
  • Elena Bravver
  • Susan Iannaccone
  • Christopher Spurney
  • Avital Cnaan
  • Heather Gordish-Dressman
  • Muscle Nerve.2020 Jun;doi: 10.1002/mus.27011.Epub 2020-06-21.

4カ国の健康な2歳未満の乳幼児および小児の呼吸数および酸素飽和度基準値に及ぼす高高度の影響:横断的研究

Effects of high altitude on respiratory rate and oxygen saturation reference values in healthy infants and children younger than 2 years in four countries: a cross-sectional study.
  • Mary E Crocker
  • Shakir Hossen
  • Dina Goodman
  • Suzanne M Simkovich
  • Miles Kirby
  • Lisa M Thompson
  • Ghislaine Rosa
  • Sarada S Garg
  • Gurusamy Thangavel
  • Eric D McCollum
  • Jennifer Peel
  • Thomas Clasen
  • William Checkley
  • Lancet Glob Health.2020 03;8(3):e362-e373. S2214-109X(19)30543-1. doi: 10.1016/S2214-109X(19)30543-1.

電池型ハイブリッドスーパーキャパシタの高エネルギー密度化に向けたNiMoO@金属被覆グラフェン・インクナノシート構造の合成を容易に行った

A facile synthesis of a NiMoO@metal-coated graphene-ink nanosheet structure towards the high energy density of a battery type-hybrid supercapacitor.
  • Venkata Thulasivarma Chebrolu
  • Balamuralitharan Balakrishnan
  • Selvaraj Aravindha Raja
  • Hee-Je Kim
  • Dalton Trans.2020 Jul;49(28):9762-9772. doi: 10.1039/d0dt00624f.

骨癌性疼痛ラットにおけるモルヒネ寛容性に対する骨近鍼と電気鍼を組み合わせた早期介入と後根神経節におけるHDACとMORの発現に及ぼす影響

[Early intervention of bone-nearby acupuncture combined with electroacupuncture on morphine tolerance in bone cancer pain rats and its effect on the expression of HDAC and MOR in dorsal root ganglia].
  • Xue-Mei Zhong
  • Jun-Fan Fang
  • Bin Jiang
  • Jie Zhou
  • Yang-Qian Cai
  • Yi Liang
  • Jian-Qiao Fang
  • Feng Chen
  • Jun-Ying Du
  • Zhongguo Zhen Jiu.2020 Apr;40(4):405-10. doi: 10.13703/j.0255-2930.20190822-k0002.

プロアポトーシスBcl-2関連タンパク質BidとBakによるスーパーオキシド誘発細胞死の実行

Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.
  • Muniswamy Madesh
  • Wei-Xing Zong
  • Brian J Hawkins
  • Subbiah Ramasamy
  • Thilagavathi Venkatachalam
  • Partha Mukhopadhyay
  • Patrick J Doonan
  • Krishna M Irrinki
  • Mohanraj Rajesh
  • Pál Pacher
  • Craig B Thompson
  • Mol. Cell. Biol..2009 Jun;29(11):3099-112. MCB.01845-08. doi: 10.1128/MCB.01845-08.Epub 2009-03-30.

-由来のPSMαペプチドは好中球のFPR2を活性化するが、β-アレスチンのリクルートと走化性を媒介する能力を欠いている

-Derived PSMα Peptides Activate Neutrophil FPR2 but Lack the Ability to Mediate β-Arrestin Recruitment and Chemotaxis.
  • Martina Sundqvist
  • Karin Christenson
  • Michael Gabl
  • André Holdfeldt
  • Karin Jennbacken
  • Thor C Møller
  • Claes Dahlgren
  • Huamei Forsman
  • J. Immunol..2019 12;203(12):3349-3360. jimmunol.1900871. doi: 10.4049/jimmunol.1900871.Epub 2019-11-06.

2030年に向けた戦略的展望:日本のアレルギー・免疫学研究-二次出版

Strategic Outlook toward 2030: Japan's research for allergy and immunology - Secondary publication.
  • Takeya Adachi
  • Keigo Kainuma
  • Koichiro Asano
  • Masayuki Amagai
  • Hiroyuki Arai
  • Ken J Ishii
  • Komei Ito
  • Eiichi Uchio
  • Motohiro Ebisawa
  • Mitsuhiro Okano
  • Kenji Kabashima
  • Kenji Kondo
  • Satoshi Konno
  • Hidehisa Saeki
  • Mariko Sonobe
  • Mizuho Nagao
  • Nobuyuki Hizawa
  • Atsuki Fukushima
  • Shigeharu Fujieda
  • Kenji Matsumoto
  • Hideaki Morita
  • Kazuhiko Yamamoto
  • Akemi Yoshimoto
  • Mayumi Tamari
  • Allergol Int.2020 Jun;S1323-8930(20)30056-3. doi: 10.1016/j.alit.2020.04.006.Epub 2020-06-26.

X-Linked Adrenoleukodystrophyにおける脳脱髄の根底にある表現型修飾因子を同定するためのマルチオーミックアプローチ

Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy.
  • Phillip A Richmond
  • Frans van der Kloet
  • Frederic M Vaz
  • David Lin
  • Anuli Uzozie
  • Emma Graham
  • Michael Kobor
  • Sara Mostafavi
  • Perry D Moerland
  • Philipp F Lange
  • Antoine H C van Kampen
  • Wyeth W Wasserman
  • Marc Engelen
  • Stephan Kemp
  • Clara D M van Karnebeek
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COL6関連ジストロフィーとデュシェンヌ筋ジストロフィーの中間型とベスレムミオパシー型における下肢筋の関与。断面研究

Lower Extremity Muscle Involvement in the Intermediate and Bethlem Myopathy Forms of COL6-Related Dystrophy and Duchenne Muscular Dystrophy: A Cross-Sectional Study.
  • Abhinandan Batra
  • Donovan J Lott
  • Rebecca Willcocks
  • Sean C Forbes
  • William Triplett
  • Jahannaz Dastgir
  • Pomi Yun
  • A Reghan Foley
  • Carsten G Bönnemann
  • Krista Vandenborne
  • Glenn A Walter
  • J Neuromuscul Dis.2020 Jun;JND190457. doi: 10.3233/JND-190457.Epub 2020-06-06.

テオフィリンとデキサメタゾンの併用は、炎症を抑制し、タバコの煙の抽出物に暴露された単球に見られるHDAC2発現の低下を防ぐ

Theophylline and dexamethasone in combination reduce inflammation and prevent the decrease in HDAC2 expression seen in monocytes exposed to cigarette smoke extract.
  • Xue-Jiao Sun
  • Zhan-Hua Li
  • Yang Zhang
  • Xiao-Ning Zhong
  • Zhi-Yi He
  • Ji-Hong Zhou
  • Si-Ning Chen
  • Yuan Feng
  • Exp Ther Med.2020 May;19(5):3425-3431. ETM-0-0-8584. doi: 10.3892/etm.2020.8584.Epub 2020-03-06.

フォルミルペプチド受容体2-G複合体の構造がリガンド認識とシグナル伝達の謎を解き明かす

Structure of formylpeptide receptor 2-G complex reveals insights into ligand recognition and signaling.
  • Youwen Zhuang
  • Heng Liu
  • X Edward Zhou
  • Ravi Kumar Verma
  • Parker W de Waal
  • Wonjo Jang
  • Ting-Hai Xu
  • Lei Wang
  • Xing Meng
  • Gongpu Zhao
  • Yanyong Kang
  • Karsten Melcher
  • Hao Fan
  • Nevin A Lambert
  • H Eric Xu
  • Cheng Zhang
  • Nat Commun.2020 02;11(1):885. 10.1038/s41467-020-14728-9. doi: 10.1038/s41467-020-14728-9.Epub 2020-02-14.

メープルシロップ尿症Ib型患者由来の誘導多能性幹細胞株(SDQLCHi006-A)は、BCKDHB遺伝子のp.R168Cおよびp.T322Iの複合ヘテロ変異を有する

An induced pluripotent stem cell line (SDQLCHi006-A) derived from a patient with maple syrup urine disease type Ib carrying compound heterozygous mutations of p.R168C and p.T322I in BCKDHB gene.
  • Yue Li
  • Haiyan Zhang
  • Beibei Yan
  • Yanyan Ma
  • Xiaomeng Yang
  • Jingyun Guan
  • Yuqiang Lv
  • Min Gao
  • Jian Ma
  • Zhongtao Gai
  • Yi Liu
  • Stem Cell Res.2019 10;40:101579. S1873-5061(19)30209-0. doi: 10.1016/j.scr.2019.101579.Epub 2019-09-14.

リジン特異的デメチラーゼ1(LSD1)を薬理学的に阻害することで,Schistosoma mansoniの生存能力を損なう全世界的な転写調節障害と超微細構造変化が誘導される.

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni.
  • Vitor Coutinho Carneiro
  • Isabel Caetano de Abreu da Silva
  • Murilo Sena Amaral
  • Adriana S A Pereira
  • Gilbert Oliveira Silveira
  • David da Silva Pires
  • Sergio Verjovski-Almeida
  • Frank J Dekker
  • Dante Rotili
  • Antonello Mai
  • Eduardo José Lopes-Torres
  • Dina Robaa
  • Wolfgang Sippl
  • Raymond J Pierce
  • M Teresa Borrello
  • A Ganesan
  • Julien Lancelot
  • Silvana Thiengo
  • Monica Ammon Fernandez
  • Amanda Roberta Revoredo Vicentino
  • Marina Moraes Mourão
  • Fernanda Sales Coelho
  • Marcelo Rosado Fantappié
  • PLoS Negl Trop Dis.2020 Jul;14(7):e0008332. PNTD-D-19-01913. doi: 10.1371/journal.pntd.0008332.Epub 2020-07-01.

過酢酸-エタノールベースの除菌剤または高度酸化プロセスを用いたドライフルーツ、ピスタチオナッツ、コーンフレークおよびチョコレートクラム上のサルモネラ菌およびリステリア・モノサイトゲネスの不活化

Inactivation of Salmonella and Listeria monocytogenes on dried fruit, pistachio nuts, cornflakes and chocolate crumb using a peracetic acid-ethanol based sanitizer or Advanced Oxidation Process.
  • Mahdiyeh Hasani
  • Fan Wu
  • Kayla Hu
  • Jeffery Farber
  • Keith Warriner
  • Int. J. Food Microbiol..2020 Jul;333:108789. S0168-1605(20)30283-X. doi: 10.1016/j.ijfoodmicro.2020.108789.Epub 2020-07-15.

太りすぎと肥満の成人の血漿リピドーム上のカルノシンサプリメントの効果:パイロット無作為化比較試験

Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial.
  • Estifanos Baye
  • Jozef Ukropec
  • Maximilian Pj de Courten
  • Silvia Vallova
  • Patrik Krumpolec
  • Timea Kurdiova
  • Giancarlo Aldini
  • Barbara Ukropcova
  • Barbora de Courten
  • Sci Rep.2017 12;7(1):17458. 10.1038/s41598-017-17577-7. doi: 10.1038/s41598-017-17577-7.Epub 2017-12-12.

デクスメデトミジンは神経炎症を調節し、ラット脊髄損傷後にα2-アドレナリン受容体シグナルを介して転帰を改善する

Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury.
  • Jiandong Gao
  • Zhihua Sun
  • Zhaoyang Xiao
  • Qihang Du
  • Xinhuan Niu
  • Gongming Wang
  • Yu-Wen Chang
  • Yongtao Sun
  • Wei Sun
  • Amity Lin
  • Jacqueline C Bresnahan
  • Mervyn Maze
  • Michael S Beattie
  • Jonathan Z Pan
  • Br J Anaesth.2019 12;123(6):827-838. S0007-0912(19)30674-9. doi: 10.1016/j.bja.2019.08.026.Epub 2019-10-14.

また,Schistosoma haematobiumの感染は,過体重・肥満者において血清コレステロール値の低下と脂質プロファイルの改善と関連していることが示唆された.

Schistosoma haematobium infection is associated with lower serum cholesterol levels and improved lipid profile in overweight/obese individuals.
  • Jeannot F Zinsou
  • Jacqueline J Janse
  • Yabo Y Honpkehedji
  • Jean Claude Dejon-Agobé
  • Noemí García-Tardón
  • Pytsje T Hoekstra
  • Marguerite Massinga-Loembe
  • Paul L A M Corstjens
  • Govert J van Dam
  • Martin Giera
  • Peter G Kremsner
  • Maria Yazdanbakhsh
  • Ayola A Adegnika
  • Bruno Guigas
  • PLoS Negl Trop Dis.2020 Jul;14(7):e0008464. PNTD-D-20-00359. doi: 10.1371/journal.pntd.0008464.Epub 2020-07-02.

親水性とラジカルフリーの4-META/MMA-TBBを中心とした新しい骨形成挙動:オッセオインテグレーション骨セメントの意味合い

Novel Osteogenic Behaviors around Hydrophilic and Radical-Free 4-META/MMA-TBB: Implications of an Osseointegrating Bone Cement.
  • Yoshihiko Sugita
  • Takahisa Okubo
  • Makiko Saita
  • Manabu Ishijima
  • Yasuyoshi Torii
  • Miyuki Tanaka
  • Chika Iwasaki
  • Takeo Sekiya
  • Masako Tabuchi
  • Naser Mohammadzadeh Rezaei
  • Takashi Taniyama
  • Nobuaki Sato
  • Juri Saruta
  • Masakazu Hasegawa
  • Makoto Hirota
  • Wonhee Park
  • Masaichi Chang-Il Lee
  • Hatsuhiko Maeda
  • Takahiro Ogawa
  • Int J Mol Sci.2020 Mar;21(7). E2405. doi: 10.3390/ijms21072405.Epub 2020-03-31.

バクテリア由来トポイソメラーゼ阻害剤のスクリーニングによるヒトDNAトポイソメラーゼIIαの新規ATP競合阻害剤の発見

Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors.
  • Žiga Skok
  • Martina Durcik
  • Darja Gramec Skledar
  • Michaela Barančoková
  • Lucija Peterlin Mašič
  • Tihomir Tomašič
  • Anamarija Zega
  • Danijel Kikelj
  • Nace Zidar
  • Janez Ilaš
  • Bioorg. Chem..2020 Jun;102:104049. S0045-2068(20)31346-8. doi: 10.1016/j.bioorg.2020.104049.Epub 2020-06-29.

原発性腫瘍が検出されなかった症例におけるEpstein-Barrウイルス(Herpesviridae, Lymphocryptovirus, HHV-4)の血清学的および分子マーカーを用いた上咽頭癌の診断

[Diagnostics of nasopharyngeal carcinoma with Epstein-Barr virus (Herpesviridae, Lymphocryptovirus, HHV-4) serological and molecular markers in cases of undetected primary tumor location.]
  • N B Senyuta
  • K V Smirnova
  • V N Kondratova
  • A V Ignatova
  • A M Mudunov
  • T E Dushenkina
  • A V Liechtenstein
  • V E Gurtsevich
  • Vopr. Virusol..2019;64(5):229-237. doi: 10.36233/0507-4088-2019-64-5-229-237.

メデトミジン塩酸塩を末梢性α-アドレナリン受容体拮抗薬バチノキサン塩酸塩を併用または併用せずに投与したイヌにおけるアチパメゾールの筋肉内投与による心血管および鎮静の逆転効果

Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α-adrenoceptor antagonist vatinoxan hydrochloride.
  • Heta Turunen
  • Marja R Raekallio
  • Juhana M Honkavaara
  • Flavia Restitutti
  • Ira J Kallio-Kujala
  • Magdy Adam
  • Katri Nevanperä
  • Mika Scheinin
  • Sofia K Männikkö
  • Heidi J Hautajärvi
  • Paula Larenza Menzies
  • Outi M Vainio
  • Am. J. Vet. Res..2019 Oct;80(10):912-922. doi: 10.2460/ajvr.80.10.912.

tPAの24時間以内の抗血小板療法:急性虚血性脳卒中に対して血栓摘出術とステント留置術の併用を必要とする患者から得られた教訓

Antiplatelet therapy within 24 hours of tPA: lessons learned from patients requiring combined thrombectomy and stenting for acute ischemic stroke.
  • Michael G Brandel
  • Yasmeen Elsawaf
  • Robert C Rennert
  • Jeffrey A Steinberg
  • David R Santiago-Dieppa
  • Arvin R Wali
  • Scott E Olson
  • J Scott Pannell
  • Alexander A Khalessi
  • J Cerebrovasc Endovasc Neurosurg.2020 Mar;22(1):1-7. jcen-22-1-1. doi: 10.7461/jcen.2020.22.1.1.Epub 2020-03-31.

ラットモデルにおけるレーザースペックルイメージングを用いた急性硬膜下血腫における開頭術時の皮質脳血流動態の可視化

Visualization of cortical cerebral blood flow dynamics during craniotomy in acute subdural hematoma using laser speckle imaging in a rat model.
  • Cheng Wang
  • Liang Xian
  • Xiangrong Chen
  • Zuanfang Li
  • Yi Fang
  • Weiming Xu
  • Liangfeng Wei
  • Weiqiang Chen
  • Shousen Wang
  • Brain Res..2020 Sep;1742:146901. S0006-8993(20)30257-2. doi: 10.1016/j.brainres.2020.146901.Epub 2020-05-20.

4種類の抗精神病薬の血漿中濃度から推定したドパミンD2受容体占有率と、統合失調症における身体的・精神的幸福感の主観的経験。無作為化NeSSy試験の結果

Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial.
  • Tanja Veselinović
  • Martin Scharpenberg
  • Martin Heinze
  • Joachim Cordes
  • Bernd Mühlbauer
  • Georg Juckel
  • Eckart Rüther
  • Michael Paulzen
  • Ekkehard Haen
  • Christoph Hiemke
  • Jürgen Timm
  • Gerhard Gründer
  • J Clin Psychopharmacol.2019 Nov/Dec;39(6):550-560. doi: 10.1097/JCP.0000000000001131.

3.0テスラMRIスキャナーによるKlingler法で固定した死後ヒト脳半球の大脳皮質上大白質路と中心核の解剖学的構造の評価

3.0 Tesla MRI scanner evaluation of supratentorial major white matter tracts and central core anatomical structures of postmortem human brain hemispheres fixed by Klingler method.
  • Murat Atar
  • Ceren Kizmazoglu
  • Ismail Kaya
  • Nevin Aydin
  • Ufuk Corumlu
  • Gulden Sozer
  • Hasan Emre Aydin
  • Orhan Kalemci
  • Nuri Karabay
  • Nurullah Yuceer
  • Br J Neurosurg.2020 Jul;:1-5. doi: 10.1080/02688697.2020.1779179.Epub 2020-07-16.

新規の非胆汁酸系FXRアゴニストであるEDP-305は、胆管反応を悪化させることなく、肝障害や線維化を強力に抑制します

A novel non-bile acid FXR agonist EDP-305 potently suppresses liver injury and fibrosis without worsening of ductular reaction.
  • Ping An
  • Guangyan Wei
  • Pinzhu Huang
  • Wenda Li
  • Xiaolong Qi
  • Yi Lin
  • Kahini A Vaid
  • Jun Wang
  • Shucha Zhang
  • Yang Li
  • Yat Sun Or
  • Li-Juan Jiang
  • Yury V Popov
  • Liver Int..2020 Jul;40(7):1655-1669. doi: 10.1111/liv.14490.Epub 2020-05-06.

USP18のノックダウンはα2aインターフェロンシグナル伝達およびインターフェロン刺激遺伝子の誘導を増加させるが、Huh7細胞における抗ウイルス活性は増加しない

Knockdown of USP18 increases α 2a interferon signaling and induction of interferon-stimulating genes but does not increase antiviral activity in Huh7 cells.
  • E J Murray
  • Frances Burden
  • Nigel Horscroft
  • Caroline Smith-Burchnell
  • Mike Westby
  • Antimicrob. Agents Chemother..2011 Sep;55(9):4311-9. AAC.00644-11. doi: 10.1128/AAC.00644-11.Epub 2011-06-27.

Y染色体の組み立てにより、性染色体進化の収束的な特徴が明らかになった

Assembly of the threespine stickleback Y chromosome reveals convergent signatures of sex chromosome evolution.
  • Catherine L Peichel
  • Shaugnessy R McCann
  • Joseph A Ross
  • Alice F S Naftaly
  • James R Urton
  • Jennifer N Cech
  • Jane Grimwood
  • Jeremy Schmutz
  • Richard M Myers
  • David M Kingsley
  • Michael A White
  • Genome Biol..2020 Jul;21(1):177. 10.1186/s13059-020-02097-x. doi: 10.1186/s13059-020-02097-x.Epub 2020-07-19.

低侵襲な頸椎手術と前頸椎椎椎間板切除術および癒合術後の隣接セグメントのバイオメカニクスの比較解析。有限要素法による研究

Comparative analysis of the biomechanics of the adjacent segments after minimally invasive cervical surgeries versus anterior cervical discectomy and fusion: A finite element study.
  • Chao Chen
  • Chen-Xi Yuchi
  • Ziwei Gao
  • Xinlong Ma
  • Dong Zhao
  • Jun-Wei Li
  • Baoshan Xu
  • Chun-Qiu Zhang
  • Zheng Wang
  • Cheng-Fei Du
  • Qiang Yang
  • J Orthop Translat.2020 Jul;23:107-112. S2214-031X(20)30036-X. doi: 10.1016/j.jot.2020.03.006.Epub 2020-04-02.