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日本語AIでPubMedを検索

歯科医師情報サイトTOP / PubMed論文検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。
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みんなが読んでいる論文

遺伝間領域の再配列に基づくラッサウイルス生ワクチン候補の開発

A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region.
  • Yingyun Cai
  • Masaharu Iwasaki
  • Daisuke Motooka
  • David X Liu
  • Shuiqing Yu
  • Kurt Cooper
  • Randy Hart
  • Ricky Adams
  • Tracey Burdette
  • Elena N Postnikova
  • Jonathan Kurtz
  • Marisa St Claire
  • Chengjin Ye
  • Jens H Kuhn
  • Luis Martínez-Sobrido
  • Juan Carlos de la Torre
  • mBio.2020 03;11(2). e00186-20. doi: 10.1128/mBio.00186-20.Epub 2020-03-24.

グルコース-6-リン酸デヒドロゲナーゼは、Ca1.2と相互作用してCa電流を増加させ、L型カルシウムチャネルの内在性不活性化を減少させる

Glucose-6-phosphate dehydrogenase increases Ca currents by interacting with Ca1.2 and reducing intrinsic inactivation of the L-type calcium channel.
  • Rakhee Gupte
  • Vidhi Dhagia
  • Petra Rocic
  • Rikuo Ochi
  • Sachin A Gupte
  • Am. J. Physiol. Heart Circ. Physiol..2020 Jul;319(1):H144-H158. doi: 10.1152/ajpheart.00727.2019.Epub 2020-05-22.

セファレキシンの皮膚バイオアベイラビリティと抗菌活性を向上させるための熱感応性・生体接着性ナノトランスファーゾームハイドロゲルハイブリッドシステムの開発のための望ましさ機能アプローチ

Desirability function approach for development of a thermosensitive and bioadhesive nanotransfersome-hydrogel hybrid system for enhanced skin bioavailability and antibacterial activity of cephalexin.
  • Sara Salatin
  • Mitra Jelvehgari
  • Drug Dev Ind Pharm.2020 Jul;:1-16. doi: 10.1080/03639045.2020.1788068.Epub 2020-07-07.

化学療法中の顆粒球-コロニー刺激因子の使用とCA27.29と循環腫瘍細胞との関連性-SUCCESS A試験の結果

Use of Granulocyte-colony Stimulating Factor During Chemotherapy and Its Association With CA27.29 and Circulating Tumor Cells-Results From the SUCCESS A Trial.
  • Philip Hepp
  • Peter A Fasching
  • Matthias W Beckmann
  • Tanja Fehm
  • Jessica Salmen
  • Carsten Hagenbeck
  • Bernadette Jäger
  • Peter Widschwendter
  • Nikolaus de Gregorio
  • Fabienne Schochter
  • Sven Mahner
  • Nadia Harbeck
  • Tobias Weissenbacher
  • Ayse-Gül Kurt
  • Thomas W P Friedl
  • Wolfgang Janni
  • Brigitte Rack
  • Clin. Breast Cancer.2018 10;18(5):e1103-e1110. S1526-8209(17)30674-2. doi: 10.1016/j.clbc.2018.06.006.Epub 2018-06-18.

工学的に設計されたヒトカテリシジン抗菌ペプチドはエボラウイルス感染を抑制する

Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection.
  • Yangsheng Yu
  • Christopher L Cooper
  • Guangshun Wang
  • M Jane Morwitzer
  • Krishna Kota
  • Julie P Tran
  • Steven B Bradfute
  • Yan Liu
  • Jiayu Shao
  • Amanda K Zhang
  • Lindsey G Luo
  • St Patrick Reid
  • Steven H Hinrichs
  • Kaihong Su
  • iScience.2020 Mar;23(4):100999. S2589-0042(20)30183-8. doi: 10.1016/j.isci.2020.100999.Epub 2020-03-22.

ボロン酸で機能化した親水性表面を持つメソポーラス磁性粒子を用いて、糖プロテオミクスのための糖ペプチドのマルチモーダル濃縮を目指します

Boronic acid-functionalized mesoporous magnetic particles with a hydrophilic surface for the multimodal enrichment of glycopeptides for glycoproteomics.
  • Lujie Yang
  • Quanqing Zhang
  • Yuanyu Huang
  • Ling Lin
  • Hartmut Schlüter
  • Ke Wang
  • Cuiping Zhang
  • Pengyuan Yang
  • Hongxiu Yu
  • Analyst.2020 Jul;doi: 10.1039/d0an00648c.Epub 2020-07-03.

ナノ構造カーボンベース電気化学（バイオ）センサーの水域および水生生物中の新たな医薬品汚染物質のスクリーニングへの応用.A Review

Application of Nanostructured Carbon-Based Electrochemical (Bio)Sensors for Screening of Emerging Pharmaceutical Pollutants in Waters and Aquatic Species: A Review.
  • Álvaro Torrinha
  • Thiago M B F Oliveira
  • Francisco W P Ribeiro
  • Adriana N Correia
  • Pedro Lima-Neto
  • Simone Morais
  • Nanomaterials (Basel).2020 Jun;10(7). E1268. doi: 10.3390/nano10071268.Epub 2020-06-29.

ドイツにおける片頭痛患者の行政的有病率と罹患率，特徴，処方パターン：レトロスペクティブなクレームデータ分析

Administrative prevalence and incidence, characteristics and prescription patterns of patients with migraine in Germany: a retrospective claims data analysis.
  • Tatjana Roessler
  • Juergen Zschocke
  • Anne Roehrig
  • Michael Friedrichs
  • Heiko Friedel
  • Zaza Katsarava
  • J Headache Pain.2020 Jul;21(1):85. 10.1186/s10194-020-01154-x. doi: 10.1186/s10194-020-01154-x.Epub 2020-07-06.

血管内皮受容体チロシンホスファターゼ：EPHB4およびTIE2との接合体および三元複合体に関連する新規基質の同定

Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2.
  • Hannes C A Drexler
  • Matthias Vockel
  • Christian Polaschegg
  • Maike Frye
  • Kevin Peters
  • Dietmar Vestweber
  • Mol. Cell Proteomics.2019 10;18(10):2058-2077. RA119.001716. doi: 10.1074/mcp.RA119.001716.Epub 2019-08-19.

Lactobacillus rhamnosus 2016SWU.05.0601は、免疫関連転写因子および腸内細菌叢の発現を調節することにより、オーバルブミンに感作されたマウスにおける免疫バランスを調節する

Lactobacillus rhamnosus 2016SWU.05.0601 regulates immune balance in ovalbumin-sensitized mice by modulating expression of the immune-related transcription factors and gut microbiota.
  • Jiajia Song
  • Yang Li
  • Jian Li
  • Hongwei Wang
  • Yu Zhang
  • Huayi Suo
  • J. Sci. Food Agric..2020 Jun;doi: 10.1002/jsfa.10554.Epub 2020-06-01.

歯科医師が口腔癌や口腔内潜在的悪性病変の早期発見に用いる手がかり：全国歯科診療連携研究ネットワークからの知見

Cues used by dentists in the early detection of oral cancer and oral potentially malignant lesions: findings from the National Dental Practice-Based Research Network.
  • Alexander Ross Kerr
  • Michael E Robinson
  • Cyril Meyerowitz
  • Douglas E Morse
  • Maria L Aguilar
  • Scott L Tomar
  • Lisa Guerrero
  • Dianne Caprio
  • Linda M Kaste
  • Sonia K Makhija
  • Rahma Mungia
  • Linda Rasubala
  • Walter J Psoter
  • Oral Surg Oral Med Oral Pathol Oral Radiol.2020 May;S2212-4403(20)31011-7. doi: 10.1016/j.oooo.2020.05.007.Epub 2020-05-23.

ソヤサポニンIIは、マウスのYB-1リン酸化とNlrp3-inflammasomeプライミングを減少させることにより、急性肝不全を予防します

Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice.
  • Fangzhao Wang
  • Shenhai Gong
  • Teng Wang
  • Lei Li
  • Haihua Luo
  • Junhao Wang
  • Chenyang Huang
  • Hongwei Zhou
  • Guiming Chen
  • Zhanguo Liu
  • Qifan Zhang
  • Yong Jiang
  • Peng Chen
  • Theranostics.2020;10(6):2714-2726. thnov10p2714. doi: 10.7150/thno.40128.Epub 2020-02-03.

Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial（CAVEAT）。修正集中化学療法とベネトグラックス併用の第Ib相用量漸増試験

Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT): A Phase Ib Dose-Escalation Study of Venetoclax Combined With Modified Intensive Chemotherapy.
  • Chong Chyn Chua
  • Andrew W Roberts
  • John Reynolds
  • Chun Yew Fong
  • Stephen B Ting
  • Jessica M Salmon
  • Sarah MacRaild
  • Adam Ivey
  • Ing Soo Tiong
  • Shaun Fleming
  • Fiona C Brown
  • Sun Loo
  • Ian J Majewski
  • Stefan K Bohlander
  • Andrew H Wei
  • J. Clin. Oncol..2020 Jul;:JCO2000572. doi: 10.1200/JCO.20.00572.Epub 2020-07-20.

YBX1ホモログYPSは、5-メチルシトシンRNAを優先的に認識することで卵巣生殖細胞幹細胞の発生を促進する

YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs.
  • Fan Zou
  • Renjun Tu
  • Bo Duan
  • Zhenlin Yang
  • Zhaohua Ping
  • Xiaoqing Song
  • Shiyuan Chen
  • Andrew Price
  • Hua Li
  • Allison Scott
  • Anoja Perera
  • Sisi Li
  • Ting Xie
  • Proc. Natl. Acad. Sci. U.S.A..2020 02;117(7):3603-3609. 1910862117. doi: 10.1073/pnas.1910862117.Epub 2020-02-03.

ヒト免疫不全ウイルスおよびC型肝炎ウイルスに感染した患者における動脈硬化性心血管系イベント

Atherosclerotic Cardiovascular Events in Patients Infected With Human Immunodeficiency Virus and Hepatitis C Virus.
  • Boun Kim Tan
  • Mathieu Chalouni
  • Dominique Salmon Ceron
  • Alexandre Cinaud
  • Laure Esterle
  • Marc Arthur Loko
  • Christine Katlama
  • Isabelle Poizot-Martin
  • Didier Neau
  • Julie Chas
  • Philippe Morlat
  • Eric Rosenthal
  • Karine Lacombe
  • Alissa Naqvi
  • Karl Barange
  • Olivier Bouchaud
  • Anne Gervais
  • Caroline Lascoux-Combe
  • Daniel Garipuy
  • Laurent Alric
  • Cécile Goujard
  • Patrick Miailhes
  • Hugues Aumaitre
  • Claudine Duvivier
  • Anne Simon
  • Jose-Luis Lopez-Zaragoza
  • David Zucman
  • François Raffi
  • Estibaliz Lazaro
  • David Rey
  • Lionel Piroth
  • François Boué
  • Camille Gilbert
  • Firouzé Bani-Sadr
  • François Dabis
  • Philippe Sogni
  • Linda Wittkop
  • Franck Boccara
  • Clin. Infect. Dis..2020 Jul;ciaa1014. doi: 10.1093/cid/ciaa1014.Epub 2020-07-20.

アペリンは、アペリン受容体、プロテインキナーゼA、細胞外シグナル制御キナーゼ1/2活性化を介して、ヒトトロフォブラストBeWo細胞による胎盤ホルモン分泌を減少させた

Apelin decreased placental hormoine secretion by human trophoblast BeWo cells via apelin receptor, protein kinase A and extracellular signal-regulated kinases 1/2 activation.
  • M Dawid
  • E Mlyczynska
  • P Kurowska
  • M Sierpowski
  • A Rak
  • J. Physiol. Pharmacol..2019 Dec;70(6). doi: 10.26402/jpp.2019.6.08.Epub 2020-02-19.

P21の組換え型は宿主の免疫応答を調節することで感染を制御している

The Recombinant Form of P21 Controls Infection by Modulating Host Immune Response.
  • Flávia Alves Martins
  • Marlus Alves Dos Santos
  • Júlia de Gouveia Santos
  • Aline Alves da Silva
  • Bruna Cristina Borges
  • Mylla Spirandelli da Costa
  • Paula Cristina Brígido Tavares
  • Samuel Cota Teixeira
  • Rebecca Tavares E Silva Brígido
  • Thaise Lara Teixeira
  • Cassiano Costa Rodrigues
  • Nadjania Saraiva de Lira Silva
  • Rayane Cristina de Oliveira
  • Laura Caroline de Faria
  • Marcela Rezende Lemes
  • Renata Graciele Zanon
  • Tatiana Carla Tomiosso
  • Juliana Reis Machado
  • Marcos Vinicius da Silva
  • Carlo José Freire Oliveira
  • Claudio Vieira da Silva
  • Front Immunol.2020;11:1010. doi: 10.3389/fimmu.2020.01010.Epub 2020-06-05.

イリ科植物のファイトケミカル組成とインビトロ生物学的活性.口腔内細菌バイオフィルムの抑制のための新たな生理活性成分の供給源

Phytochemical Composition and In Vitro Biological Activity of spp. (Iridaceae): A New Source of Bioactive Constituents for the Inhibition of Oral Bacterial Biofilms.
  • Lan Hoang
  • František Beneš
  • Marie Fenclová
  • Olga Kronusová
  • Viviana Švarcová
  • Kateřina Řehořová
  • Eva Baldassarre Švecová
  • Miroslav Vosátka
  • Jana Hajšlová
  • Petr Kaštánek
  • Jitka Viktorová
  • Tomáš Ruml
  • Antibiotics (Basel).2020 Jul;9(7). E403. doi: 10.3390/antibiotics9070403.Epub 2020-07-11.

2つの木材腐朽菌Ganoderma applanatumとLaetiporus sulphureusによるNSAIDsの新規コビマス分解。リグニン分解酵素の誘導、等温および速度論的研究

Novel cobiomass degradation of NSAIDs by two wood rot fungi, Ganoderma applanatum and Laetiporus sulphureus: Ligninolytic enzymes induction, isotherm and kinetic studies.
  • Paul Olusegun Bankole
  • Adedotun Adeyinka Adekunle
  • Byong-Hun Jeon
  • Sanjay Prabhu Govindwar
  • Ecotoxicol. Environ. Saf..2020 Jul;203:110997. S0147-6513(20)30836-8. doi: 10.1016/j.ecoenv.2020.110997.Epub 2020-07-16.

Alinity m HIV-1アッセイの性能の多施設臨床比較評価

Multicenter clinical comparative evaluation of Alinity m HIV-1 assay performance.
  • Patrick Braun
  • Allison Glass
  • Leana Maree
  • Maria Krügel
  • Monia Pacenti
  • Francesco Onelia
  • Rory Gunson
  • Emily Goldstein
  • Laura Martínez-García
  • Juan-Carlos Galán
  • Alba Vilas
  • Jodie D'costa
  • Rizmina Sameer
  • Robert Ehret
  • Heribert Knechten
  • Gudrun Naeth
  • Magali Bouvier-Alias
  • Natalia Marlowe
  • Michael J Palm
  • Ajith M Joseph
  • Jens Dhein
  • Birgit Reinhardt
  • Karin Pfeifer
  • Danijela Lucic
  • Martin Obermeier
  • J. Clin. Virol..2020 Jul;129:104530. S1386-6532(20)30272-9. doi: 10.1016/j.jcv.2020.104530.Epub 2020-07-03.

CTGリピート選択的化学スクリーニングにより、微小管阻害剤が有毒CUG RNAレベルの選択的調節因子として同定された

A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels.
  • Kaalak Reddy
  • Jana R Jenquin
  • Ona L McConnell
  • John D Cleary
  • Jared I Richardson
  • Belinda S Pinto
  • Maja C Haerle
  • Elizabeth Delgado
  • Lori Planco
  • Masayuki Nakamori
  • Eric T Wang
  • J Andrew Berglund
  • Proc. Natl. Acad. Sci. U.S.A..2019 10;116(42):20991-21000. 1901893116. doi: 10.1073/pnas.1901893116.Epub 2019-09-30.

SARS-CoV-2感染後の急性低運動性硬直症候群

Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection.
  • Antonio Méndez-Guerrero
  • María Isabel Laespada-García
  • Adolfo Gómez-Grande
  • Mariano Ruiz-Ortiz
  • Víctor Antonio Blanco-Palmero
  • Francisco Javier Azcarate-Diaz
  • Pablo Rábano-Suárez
  • Eva Álvarez-Torres
  • Carlos Pablo de Fuenmayor-Fernández de la Hoz
  • Diana Vega Pérez
  • Raquel Rodríguez-Montalbán
  • Alfredo Pérez-Rivilla
  • Javier Sayas Catalán
  • Ana Ramos- González
  • Jesús González de la Aleja
  • Neurology.2020 Jul;10.1212/WNL.0000000000010282. doi: 10.1212/WNL.0000000000010282.Epub 2020-07-08.

Baicalinは、RhoA-ROCK経路を介してTh1およびTh17応答を抑制し、Treg応答を促進することで、敗血症に伴う膵臓損傷を改善することが示唆された

Baicalin suppresses Th1 and Th17 responses and promotes Treg response to ameliorate sepsis-associated pancreatic injury via the RhoA-ROCK pathway.
  • Pingping Liu
  • Zhenghui Xiao
  • Haipeng Yan
  • Xiulan Lu
  • Xinping Zhang
  • Lan Luo
  • Caixia Long
  • Yimin Zhu
  • Int. Immunopharmacol..2020 Jun;86:106685. S1567-5769(20)30273-3. doi: 10.1016/j.intimp.2020.106685.Epub 2020-06-19.

単細胞トランスクリプトミクスは、上咽頭癌の予後に関連する免疫細胞の多様性と免疫サブタイプの根底にある制御因子を明らかにした

Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.
  • Yu-Pei Chen
  • Jian-Hua Yin
  • Wen-Fei Li
  • Han-Jie Li
  • Dong-Ping Chen
  • Cui-Juan Zhang
  • Jia-Wei Lv
  • Ya-Qin Wang
  • Xiao-Min Li
  • Jun-Yan Li
  • Pan-Pan Zhang
  • Ying-Qin Li
  • Qing-Mei He
  • Xiao-Jing Yang
  • Yuan Lei
  • Ling-Long Tang
  • Guan-Qun Zhou
  • Yan-Ping Mao
  • Chen Wei
  • Ke-Xu Xiong
  • Hong-Bo Zhang
  • Shi-Da Zhu
  • Yong Hou
  • Ying Sun
  • Michael Dean
  • Ido Amit
  • Kui Wu
  • Dong-Ming Kuang
  • Gui-Bo Li
  • Na Liu
  • Jun Ma
  • Cell Res..2020 Jul;10.1038/s41422-020-0374-x. doi: 10.1038/s41422-020-0374-x.Epub 2020-07-20.

妊娠糖尿病の予測因子としての皮下脂肪および内臓脂肪の超音波評価：システマティックレビュー

Ultrasound evaluation of subcutaneous and visceral abdominal fat as a predictor of gestational diabetes mellitus: a systematic review.
  • Fernanda Teixeira Benevides
  • Edward Araujo Júnior
  • Carla Soraya Costa Maia
  • Renan Magalhães Montenegro Junior
  • Francisco Herlânio Costa Carvalho
  • J. Matern. Fetal. Neonatal. Med..2020 Jun;:1-11. doi: 10.1080/14767058.2020.1781808.Epub 2020-06-21.

Joubert Syndromeにおける網膜電図検査。将来の標的治療の有効性を評価するための提案された客観的方法

Electroretinographic Assessment in Joubert Syndrome: A Suggested Objective Method to Evaluate the Effectiveness of Future Targeted Treatment.
  • Giulio Ruberto
  • Vincenzo Parisi
  • Chiara Bertone
  • Sabrina Signorini
  • Mauro Antonini
  • Enza Maria Valente
  • Federica Manzoni
  • Valentina Serpieri
  • Riccardo Fausto
  • Luciano Quaranta
  • Adv Ther.2020 Jul;10.1007/s12325-020-01432-9. doi: 10.1007/s12325-020-01432-9.Epub 2020-07-15.

ウイルスモニタリングのための磁性誘導性微小電極の設計：B型肝炎ウイルスのためのモデル化と実現可能性

Designing a magnetic inductive micro-electrode for virus monitoring: modelling and feasibility for hepatitis B virus.
  • Elias Alipour
  • Seyed Peyman Shariatpanahi
  • Hedayatollah Ghourchian
  • Benoit Piro
  • Morteza Fathipour
  • Seyed Mehdi Boutorabi
  • Sergey L Znoyko
  • Petr I Nikitin
  • Mikrochim Acta.2020 Jul;187(8):463. 10.1007/s00604-020-04429-x. doi: 10.1007/s00604-020-04429-x.Epub 2020-07-20.

アリニティーm HCVアッセイの性能の多施設臨床評価

Multicenter clinical evaluation of alinity m HCV assay performance.
  • Stéphane Chevaliez
  • Francesco Onelia
  • Monia Pacenti
  • Emily Goldstein
  • Juan-Carlos Galán
  • Laura Martínez-García
  • Alba Vilas
  • Allison Glass
  • Leana Maree
  • Maria Krügel
  • Robert Ehret
  • Heribert Knechten
  • Patrick Braun
  • Gudrun Naeth
  • Sara Bonanzinga
  • Kathy Jackson
  • Klara Abravaya
  • Jens Dhein
  • Shihai Huang
  • Ajith M Joseph
  • Danijela Lucic
  • Natalia Marlowe
  • Michael J Palm
  • Karin Pfeifer
  • Dan Toolsie
  • Birgit Reinhardt
  • Martin Obermeier
  • Rory Gunson
  • J. Clin. Virol..2020 Jul;129:104531. S1386-6532(20)30273-0. doi: 10.1016/j.jcv.2020.104531.Epub 2020-07-03.

MRI陰性の巣状皮質異形成IIB型患者における高度動的統計パラメトリックマッピングと脳磁図法を用いたてんかん原性焦点の検出

Detection of epileptogenic focus using advanced dynamic statistical parametric mapping with magnetoencephalography in a patient with MRI-negative focal cortical dysplasia type IIB.
  • Won Seok Chang
  • Midori Nakajima
  • Ayako Ochi
  • Elysa Widjaja
  • James T Rutka
  • Ivanna Yau
  • Shiro Baba
  • Hiroshi Otsubo
  • J Neurosurg Pediatr.2019 Oct;:1-5. 2019.7.PEDS1948. doi: 10.3171/2019.7.PEDS1948.Epub 2019-10-11.

N-パルミトイル-O-ホスホコリン-セリンとスフィンゴシルホスホリルコリンの同時液体クロマトグラフィー/タンデム質量分析に基づくニーマンピック病の診断スクリーニング法の開発

Development of a diagnostic screening strategy for Niemann-Pick diseases based on simultaneous liquid chromatography/tandem mass spectrometry analyses of N-palmitoyl-O-phosphocholine-serine and sphingosylphosphorylcholine.
  • Anna Iwahori
  • Masamitsu Maekawa
  • Aya Narita
  • Akie Kato
  • Toshihiro Sato
  • Jiro Ogura
  • Yu Sato
  • Masafumi Kikuchi
  • Atsuko Noguchi
  • Katsumi Higaki
  • Torayuki Okuyama
  • Tsutomu Takahashi
  • Yoshikatsu Eto
  • Nariyasu Mano
  • Biol. Pharm. Bull..2020 Jun;doi: 10.1248/bpb.b20-00400.Epub 2020-06-25.

小児、青年、若年成人における薬剤耐性てんかん治療におけるペランパネルの有効性と血清中濃度：12歳未満と12歳以上の患者の比較

Efficacy and serum concentrations of perampanel for treatment of drug-resistant epilepsy in children, adolescents, and young adults: comparison of patients younger and older than 12 years.
  • Satoru Ikemoto
  • Shin-Ichiro Hamano
  • Yuko Hirata
  • Ryuki Matsuura
  • Reiko Koichihara
  • Seizure.2019 Dec;73:75-78. S1059-1311(19)30136-0. doi: 10.1016/j.seizure.2019.10.023.Epub 2019-11-05.

冠動脈疾患治療のための5-リポキシゲナーゼ活性化蛋白質阻害剤の新規化学シリーズの開発

Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease.
  • Malin Lemurell
  • Johan Ulander
  • Hans Emtenäs
  • Susanne Winiwarter
  • Johan Broddefalk
  • Marianne Swanson
  • Martin A Hayes
  • Luna Prieto Garcia
  • Annika Westin Eriksson
  • Johan Meuller
  • Johan Cassel
  • Gabrielle Saarinen
  • Zhong-Qing Yuan
  • Christian Löfberg
  • Staffan Karlsson
  • Monica Sundqvist
  • Carl Whatling
  • J. Med. Chem..2019 05;62(9):4325-4349. doi: 10.1021/acs.jmedchem.8b02012.Epub 2019-04-15.

前立腺閉塞症良性疾患に対するUNBLOCSランダム化比較試験における前立腺の経尿道的切除術対チュリウムレーザー経尿道的気化切除術のCost-Effectiveness

The Cost-Effectiveness of Transurethral resection of the prostate versus Thulium laser transurethral vaporesection of the prostate in the UNBLOCS randomised controlled trial for benign prostatic obstruction.
  • S M Noble
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  • J Worthington
  • H Hashim
  • H Taylor
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  • S Brookes
  • P Abrams
  • L Johnson
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  • T Page
  • S Swami
  • J A Lane
  • BJU Int..2020 Jun;doi: 10.1111/bju.15138.Epub 2020-06-17.

HIV感染者におけるcART開始後の治療変更：ドイツClinSurv HIVコホート2005-2017のレトロスペクティブ分析

Treatment modification after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005-2017.
  • Melanie Stecher
  • Philipp Schommers
  • Christian Kollan
  • Matthias Stoll
  • Frieder Kuhlendahl
  • Hans-Jürgen Stellbrink
  • Jan-Christian Wasmuth
  • Christoph Stephan
  • Laura Hamacher
  • Clara Lehmann
  • Christoph Boesecke
  • Johannes Bogner
  • Stefan Esser
  • Carlos Fritzsche
  • Annette Haberl
  • Christian Hoffmann
  • Björn Jensen
  • Carolynne Schwarze-Zander
  • Martin Platten
  • Gerd Fätkenheuer
  • Daniel Schmidt
  • Barbara Gunsenheimer-Bartmeyer
  • Jörg Janne Vehreschild
  • Infection.2020 Jul;10.1007/s15010-020-01469-6. doi: 10.1007/s15010-020-01469-6.Epub 2020-07-01.

Toll-like Receptor 4 (TLR4)の遮断は、高グルコースに曝露されたライディッヒ細胞において酸化ストレスを軽減し、phospho-ERK1/2レベルを回復させます

Blockade of Toll-like receptor 4 (TLR4) reduces oxidative stress and restores phospho-ERK1/2 levels in Leydig cells exposed to high glucose.
  • Tatiana Karpova
  • Amanda Almeida de Oliveira
  • Huda Naas
  • Fernanda Priviero
  • Kenia Pedrosa Nunes
  • Life Sci..2020 Mar;245:117365. S0024-3205(20)30112-0. doi: 10.1016/j.lfs.2020.117365.Epub 2020-01-27.

フェニル-2,4,6-トリメチルベンゾイルホスフィン酸リチウムで光重合したゼラチンメタクリロイル系ハイドロゲルのヒト初代腎近位尿細管上皮細胞における毒性と光増感性の評価

Toxicity and photosensitizing assessment of gelatin methacryloyl-based hydrogels photoinitiated with lithium phenyl-2,4,6-trimethylbenzoylphosphinate in human primary renal proximal tubule epithelial cells.
  • Alexander K Nguyen
  • Peter L Goering
  • Vytas Reipa
  • Roger J Narayan
  • Biointerphases.2019 05;14(2):021007. doi: 10.1116/1.5095886.Epub 2019-05-03.

腫瘍細胞株のプロテオーム活性のランドスケープが薬物反応を決定する

Proteome activity landscapes of tumor cell lines determine drug responses.
  • Martin Frejno
  • Chen Meng
  • Benjamin Ruprecht
  • Thomas Oellerich
  • Sebastian Scheich
  • Karin Kleigrewe
  • Enken Drecoll
  • Patroklos Samaras
  • Alexander Hogrebe
  • Dominic Helm
  • Julia Mergner
  • Jana Zecha
  • Stephanie Heinzlmeir
  • Mathias Wilhelm
  • Julia Dorn
  • Hans-Michael Kvasnicka
  • Hubert Serve
  • Wilko Weichert
  • Bernhard Kuster
  • Nat Commun.2020 Jul;11(1):3639. 10.1038/s41467-020-17336-9. doi: 10.1038/s41467-020-17336-9.Epub 2020-07-20.

プロテオームとタンパク質のリン酸化の変化は、ポプラ植物のカドミウム毒性を緩和するための外因性窒素の保護的役割を明らかにした

Changes in Proteome and Protein Phosphorylation Reveal the Protective Roles of Exogenous Nitrogen in Alleviating Cadmium Toxicity in Poplar Plants.
  • Jinliang Huang
  • Xiaolu Wu
  • Feifei Tian
  • Qi Chen
  • Pengrui Luo
  • Fan Zhang
  • Xueqin Wan
  • Yu Zhong
  • Qinglin Liu
  • Tiantian Lin
  • Int J Mol Sci.2019 Dec;21(1). E278. doi: 10.3390/ijms21010278.Epub 2019-12-31.

アフリカにおける COVID-19 パンデミック時の定期的な小児予防接種：SARS-CoV-2 感染の過剰リスクと健康上の利益の便益リスク分析

Routine childhood immunisation during the COVID-19 pandemic in Africa: a benefit-risk analysis of health benefits versus excess risk of SARS-CoV-2 infection.
  • Kaja Abbas
  • Simon R Procter
  • Kevin van Zandvoort
  • Andrew Clark
  • Sebastian Funk
  • Tewodaj Mengistu
  • Dan Hogan
  • Emily Dansereau
  • Mark Jit
  • Stefan Flasche
  • Lancet Glob Health.2020 Jul;S2214-109X(20)30308-9. doi: 10.1016/S2214-109X(20)30308-9.Epub 2020-07-17.

ポリ(2-ヒドロキシエチルメタクリレート)をベースとした複合非晶質固体分散体。親水性不溶性高分子担体からの薬物放出に関する研究（多孔質化剤の存在下および非存在下での研究

Complex amorphous solid dispersions based on poly(2-hydroxyethyl methacrylate): Study of drug release from a hydrophilic insoluble polymeric carrier in the presence and absence of a porosity increasing agent.
  • Melissa Everaerts
  • Guy Van den Mooter
  • Int J Pharm.2019 Jul;566:77-88. S0378-5173(19)30399-0. doi: 10.1016/j.ijpharm.2019.05.040.Epub 2019-05-16.

孵化したばかりの日本のメダカにおける転写応答は、希釈アスファルト曝露後の発生奇形と関連している

Transcriptional responses in newly-hatched Japanese medaka (Oryzias latipes) associated with developmental malformations following diluted bitumen exposure.
  • Barry N Madison
  • Sarah J Wallace
  • Jing Zhang
  • Peter V Hodson
  • Valerie S Langlois
  • Comp. Biochem. Physiol. Part D Genomics Proteomics.2020 May;35:100685. S1744-117X(20)30032-0. doi: 10.1016/j.cbd.2020.100685.Epub 2020-05-06.

新しい近赤外ハイパースペクトルイメージング（NIR-HSI）法を用いて、水生サンプル中の微小なマイクロプラスチックを迅速かつ直接検出する

Rapid and direct detection of small microplastics in aquatic samples by a new near infrared hyperspectral imaging (NIR-HSI) method.
  • Stefania Piarulli
  • Giorgia Sciutto
  • Paolo Oliveri
  • Cristina Malegori
  • Silvia Prati
  • Rocco Mazzeo
  • Laura Airoldi
  • Chemosphere.2020 Jul;260:127655. S0045-6535(20)31850-6. doi: 10.1016/j.chemosphere.2020.127655.Epub 2020-07-10.

顎関節症を伴う若年性特発性関節炎における疼痛および開口部に対する関節内コルチコステロイド注射の効果。システマティックレビューとメタアナリシス

Effect of intra-articular corticosteroid injections on pain and mouth opening in juvenile idiopathic arthritis with temporomandibular involvement: A systematic review and meta-analysis.
  • Gregory S Antonarakis
  • Adrien Blanc
  • Delphine S Courvoisier
  • Paolo Scolozzi
  • J Craniomaxillofac Surg.2020 Jun;S1010-5182(20)30155-4. doi: 10.1016/j.jcms.2020.06.010.Epub 2020-06-27.

低磁場磁気共鳴イメージングを用いた流体減衰反転回復シーケンス上の酸素誘発性イヌ脳脊髄液の高輝度化の低減のための適切な霊感酸素の割合

Proper fraction of inspired oxygen for reduction of oxygen-induced canine cerebrospinal fluid hyperintensity on fluid attenuation inversion recovery sequence using low-field magnetic resonance imaging.
  • Moonjung Jang
  • Jaewoo Hwang
  • Jihye Nam
  • Dalhae Kim
  • Wongyun Son
  • Inhyung Lee
  • Mincheol Choi
  • Junghee Yoon
  • J. Vet. Med. Sci..2020 Jul;doi: 10.1292/jvms.20-0060.Epub 2020-07-20.

消化管の神経内分泌がんと神経内分泌非神経内分泌混合新生物は予後が同じ？12,878例のデータベース解析

Do neuroendocrine carcinomas and mixed neuroendocrine-non-neuroendocrine neoplasm of the gastrointestinal tract have the same prognosis? A database analysis of 12,878 cases.
  • Huiying Shi
  • Cuihua Qi
  • Lingjun Meng
  • Hailing Yao
  • Chen Jiang
  • Mengke Fan
  • Suya Pang
  • Qin Zhang
  • Rong Lin
  • Ther Adv Endocrinol Metab.2020;11:2042018820938304. 10.1177_2042018820938304. doi: 10.1177/2042018820938304.Epub 2020-07-06.

ヒト免疫不全ウイルスの母子感染予防のための非ヌクレオシド系逆転写抑制剤-高活性抗レトロウイルス療法の効果には治療経験と妊娠の繰り返しが影響する

Treatment Experience and Repeat Pregnancy Impact the Effectiveness of Non-Nucleoside Reverse Transcription Inhibitor-Highly Active Antiretroviral Therapy for the Prevention of Mother to Child Transmission of Human Immunodeficiency Virus.
  • Indira B Martin
  • Stanley Read
  • Richard Harrigan
  • M Perry Gomez
  • AIDS Res. Hum. Retroviruses.2020 Jun;doi: 10.1089/AID.2019.0001.Epub 2020-06-09.

北極・南極海堆積物中のポリ塩化ジベンゾ-p-ダイオキシン類とジベンゾフラン類の前駆体。気候変動に直面した環境問題

Precursors of polychlorinated dibenzo-p-dioxins and dibenzofurans in Arctic and Antarctic marine sediments: Environmental concern in the face of climate change.
  • Marta Ewelina Kobusińska
  • Krzysztof Konrad Lewandowski
  • Anna Panasiuk
  • Leszek Łęczyński
  • Magdalena Urbaniak
  • Tadeusz Ossowski
  • Elżbieta Niemirycz
  • Chemosphere.2020 Jul;260:127605. S0045-6535(20)31800-2. doi: 10.1016/j.chemosphere.2020.127605.Epub 2020-07-10.

酵母を用いたスクリーニングにより、ニーマンピック病タイプCで影響を受ける細胞経路が明らかになった

Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C.
  • Alexandria Colaco
  • María E Fernández-Suárez
  • Dawn Shepherd
  • Lihi Gal
  • Chen Bibi
  • Silvia Chuartzman
  • Alan Diot
  • Karl Morten
  • Emily Eden
  • Forbes D Porter
  • Joanna Poulton
  • Nick Platt
  • Maya Schuldiner
  • Frances M Platt
  • Life Sci Alliance.2020 Jul;3(7). e201800253. doi: 10.26508/lsa.201800253.Epub 2020-06-02.

全ゲノムシークエンシングにより解決された進行性偽リウマチ性異形成：WISP3の新規変異と文献のレビュー

Progressive Pseudorheumatoid Dysplasia resolved by whole exome sequencing: a novel mutation in WISP3 and review of the literature.
  • Ben Pode-Shakked
  • Asaf Vivante
  • Ortal Barel
  • Shai Padeh
  • Dina Marek-Yagel
  • Alvit Veber
  • Shachar Abudi
  • Aviva Eliyahu
  • Irit Tirosh
  • Shiri Shpilman
  • Shirlee Shril
  • Friedhelm Hildebrandt
  • Mordechai Shohat
  • Yair Anikster
  • BMC Med. Genet..2019 03;20(1):53. 10.1186/s12881-019-0787-x. doi: 10.1186/s12881-019-0787-x.Epub 2019-03-29.

Intrigue.イマチニブ後の進行性消化管間質腫瘍を対象としたリプレチニブ対スニチニブの第III相試験

Intrigue: Phase III study of ripretinib versus sunitinib in advanced gastrointestinal stromal tumor after imatinib.
  • John Nemunaitis
  • Sebastian Bauer
  • Jean-Yves Blay
  • Khalil Choucair
  • Hans Gelderblom
  • Suzanne George
  • Patrick Schöffski
  • Margaret von Mehren
  • John Zalcberg
  • Haroun Achour
  • Rodrigo Ruiz-Soto
  • Michael C Heinrich
  • Future Oncol.2020 Jan;16(1):4251-4264. doi: 10.2217/fon-2019-0633.Epub 2019-11-22.

ターンオーバー、ミネラル化、体積分類の潜在的バイオマーカー。血液透析患者におけるNMRメタボロミクスを用いた結果．

Potential Biomarkers of the Turnover, Mineralization, and Volume Classification: Results Using NMR Metabolomics in Hemodialysis Patients.
  • Aline L Baptista
  • Kallyandra Padilha
  • Pamella A Malagrino
  • Gabriela Venturini
  • Ana Cm Zeri
  • Luciene M Dos Reis
  • Janaina S Martins
  • Vanda Jorgetti
  • Alexandre C Pereira
  • Silvia M Titan
  • Rosa Ma Moyses
  • JBMR Plus.2020 Jul;4(7):e10372. JBM410372. doi: 10.1002/jbm4.10372.Epub 2020-05-27.

重複する臨床病理学的特徴を有する赤色染料による遅延性タトゥー反応。高周波超音波および線間光干渉断層撮影による検査

Delayed Tattoo Reaction From Red Dye With Overlapping Clinicopathological Features: Examination With High-Frequency Ultrasound and Line-Field Optical Coherence Tomography.
  • Linda Tognetti
  • Sean Ekinde
  • Cyril Habougit
  • Elisa Cinotti
  • Pietro Rubegni
  • Jean Luc Perrot
  • Dermatol Pract Concept.2020 Jul;10(3):e2020053. dp1003a53. doi: 10.5826/dpc.1003a53.Epub 2020-06-29.

健康活動プログラムの効果の持続性と費用対効果：プライマリケアでのカウンセラーによるうつ病の短期心理治療：無作為化比較試験の12ヶ月間の追跡調査

Sustained effectiveness and cost-effectiveness of the Healthy Activity Programme, a brief psychological treatment for depression delivered by lay counsellors in primary care: 12-month follow-up of a randomised controlled trial.
  • Benedict Weobong
  • Helen A Weiss
  • David McDaid
  • Daisy R Singla
  • Steven D Hollon
  • Abhijit Nadkarni
  • A-La Park
  • Bhargav Bhat
  • Basavraj Katti
  • Arpita Anand
  • Sona Dimidjian
  • Ricardo Araya
  • Michael King
  • Lakshmi Vijayakumar
  • G Terence Wilson
  • Richard Velleman
  • Betty R Kirkwood
  • Christopher G Fairburn
  • Vikram Patel
  • PLoS Med..2017 Sep;14(9):e1002385. PMEDICINE-D-17-01349. doi: 10.1371/journal.pmed.1002385.Epub 2017-09-12.