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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

メトトレキサートに対する反応が不十分な関節リウマチ患者におけるバリシチニブと他の治療の有効性を比較するためのネットワークメタアナリシス

A Network Meta-Analysis to Compare Effectiveness of Baricitinib and Other Treatments in Rheumatoid Arthritis Patients with Inadequate Response to Methotrexate.
  • Walid Fakhouri
  • Xiaofei Wang
  • Inmaculada de La Torre
  • Claudia Nicolay
  • J Health Econ Outcomes Res.2020;7(1):10-23. jheor-7-1-12273. doi: 10.36469/jheor.2020.12273.Epub 2020-04-10.

重症筋無力症患者のCD4 T細胞は、IL-21、IL-4、IL-17Aの産生が増加し、PD-1とICOSの存在が高いことが特徴である

CD4 T Cells of Myasthenia Gravis Patients Are Characterized by Increased IL-21, IL-4, and IL-17A Productions and Higher Presence of PD-1 and ICOS.
  • Merve Çebi
  • Hacer Durmus
  • Fikret Aysal
  • Berker Özkan
  • Gizem Engin Gül
  • Arman Çakar
  • Mehmet Hocaoglu
  • Metin Mercan
  • Sibel P Yentür
  • Melih Tütüncü
  • Vildan Yayla
  • Onur Akan
  • Öner Dogan
  • Yeşim Parman
  • Güher Saruhan-Direskeneli
  • Front Immunol.2020;11:809. doi: 10.3389/fimmu.2020.00809.Epub 2020-05-19.

アネキシンA2の枯渇は、急性リケッチアおよびエボラウイルス感染によって誘発される脳内微小出血を悪化させる

Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections.
  • Zhengchen Su
  • Qing Chang
  • Aleksandra Drelich
  • Thomas Shelite
  • Barbara Judy
  • Yakun Liu
  • Jie Xiao
  • Changchen Zhou
  • Xi He
  • Yang Jin
  • Tais Saito
  • Shaojun Tang
  • Lynn Soong
  • Maki Wakamiya
  • Xiang Fang
  • Alexander Bukreyev
  • Thomas Ksiazek
  • William K Russell
  • Bin Gong
  • PLoS Negl Trop Dis.2020 Jul;14(7):e0007960. PNTD-D-19-01978. doi: 10.1371/journal.pntd.0007960.Epub 2020-07-20.

キノキサリン-7-カルボキシレート1,4-ジ-N-オキサイドのE. histolyticaに対する生物学的活性とチオレドキシン還元酵素阻害剤としての分析

Biological activity of esters of quinoxaline-7-carboxylate 1,4-di-N-oxide against E. histolytica and their analysis as potential thioredoxin reductase inhibitors.
  • Jacqueline Soto-Sánchez
  • Luis A Caro-Gómez
  • Alma D Paz-González
  • Laurence A Marchat
  • Gildardo Rivera
  • Rosa Moo-Puc
  • Diego G Arias
  • Esther Ramírez-Moreno
  • Parasitol. Res..2020 Feb;119(2):695-711. 10.1007/s00436-019-06580-8. doi: 10.1007/s00436-019-06580-8.Epub 2020-01-06.

Salivary Scavenger and Agglutinin (SALSA) Is Expressed in Mucosal Epithelial Cells and Decreased in Bronchial Epitheum of Asthmatic Horses(唾液スカベンジャーとアグルチニン(SALSA)は粘膜上皮細胞で発現し、喘息馬の気管支上皮で減少しています

Salivary Scavenger and Agglutinin (SALSA) Is Expressed in Mucosal Epithelial Cells and Decreased in Bronchial Epithelium of Asthmatic Horses.
  • Gary Kwok Cheong Lee
  • Laurence Tessier
  • Dorothee Bienzle
  • Front Vet Sci.2019;6:418. doi: 10.3389/fvets.2019.00418.Epub 2019-11-29.

スペインで一般的に消費されている地中海および北東大西洋の魚類に見られるアニサキス種とヒステロチラシ種。疫学的、分子的、形態学的判別分析

Anisakis and Hysterothylacium species in Mediterranean and North-East Atlantic fishes commonly consumed in Spain: Epidemiological, molecular and morphometric discriminant analysis.
  • Xavier Roca-Geronès
  • Matías Segovia
  • Carla Godínez-González
  • Roser Fisa
  • Isabel Montoliu
  • Int. J. Food Microbiol..2020 Jul;325:108642. S0168-1605(20)30136-7. doi: 10.1016/j.ijfoodmicro.2020.108642.Epub 2020-04-15.

第三次医療機関におけるパンデミック対策のための迅速な対応インフラ:2020年2月~3月にドイツ・ケルンで発生したCOVID-19アウトブレイクから得られた教訓

Rapid response infrastructure for pandemic preparedness in a tertiary care hospital: lessons learned from the COVID-19 outbreak in Cologne, Germany, February to March 2020.
  • Max Augustin
  • Philipp Schommers
  • Isabelle Suárez
  • Philipp Koehler
  • Henning Gruell
  • Florian Klein
  • Christian Maurer
  • Petra Langerbeins
  • Vanessa Priesner
  • Kirsten Schmidt-Hellerau
  • Jakob J Malin
  • Melanie Stecher
  • Norma Jung
  • Gerhard Wiesmüller
  • Arne Meissner
  • Janine Zweigner
  • Georg Langebartels
  • Felix Kolibay
  • Victor Suárez
  • Volker Burst
  • Philippe Valentin
  • Dirk Schedler
  • Oliver A Cornely
  • Michael Hallek
  • Gerd Fätkenheuer
  • Jan Rybniker
  • Clara Lehmann
  • Euro Surveill..2020 05;25(21). doi: 10.2807/1560-7917.ES.2020.25.21.2000531.

Oxford Nanopore PromethIONシーケンシングとHi-C技術を用いた、アオカワカワヒメジ(Thamnaconus septentrionalis)の染色体レベルでのゲノムアセンブリー

Chromosome-level genome assembly of the greenfin horse-faced filefish (Thamnaconus septentrionalis) using Oxford Nanopore PromethION sequencing and Hi-C technology.
  • Li Bian
  • Fenghui Li
  • Jianlong Ge
  • Pengfei Wang
  • Qing Chang
  • Shengnong Zhang
  • Jie Li
  • Changlin Liu
  • Kun Liu
  • Xintian Liu
  • Xuming Li
  • Hongju Chen
  • Siqing Chen
  • Changwei Shao
  • Zhishu Lin
  • Mol Ecol Resour.2020 May;doi: 10.1111/1755-0998.13183.Epub 2020-05-10.

イースタンウッドチャック( )のゲノム配列 - B型慢性肝炎の前臨床モデル動物

The Genome Sequence of the Eastern Woodchuck () - A Preclinical Animal Model for Chronic Hepatitis B.
  • Tyler S Alioto
  • Fernando Cruz
  • Jèssica Gómez-Garrido
  • Miriam Triyatni
  • Marta Gut
  • Leonor Frias
  • Anna Esteve-Codina
  • Stephan Menne
  • Anna Kiialainen
  • Nadine Kumpesa
  • Fabian Birzele
  • Roland Schmucki
  • Ivo G Gut
  • Olivia Spleiss
  • G3 (Bethesda).2019 12;9(12):3943-3952. g3.119.400413. doi: 10.1534/g3.119.400413.Epub 2019-12-03.

DMSOを介したいくつかの酵母プリオン変異体の治癒には、Hsp104の発現とタンパク質の可溶化が関与しており、いくつかのオートファジー関連遺伝子(atg)変異体では減少している

DMSO-mediated curing of several yeast prion variants involves Hsp104 expression and protein solubilization, and is decreased in several autophagy related gene (atg) mutants.
  • Jane E Dorweiler
  • Joanna O Obaoye
  • Mitch J Oddo
  • Francesca M Shilati
  • Grace M Scheidemantle
  • Thomas J Coleman
  • Jacob A Reilly
  • Gregory R Smith
  • Anita L Manogaran
  • PLoS ONE.2020;15(3):e0229796. PONE-D-19-23870. doi: 10.1371/journal.pone.0229796.Epub 2020-03-05.

ホモ接合性マッピングと全エクソームシークエンシングにより、サウジアラビアのある家族のコーエン症候群の正確な診断が可能となった

Homozygosity mapping and whole exome sequencing provide exact diagnosis of Cohen syndrome in a Saudi family.
  • Jamil A Hashmi
  • Fatima Fadhli
  • Ahmed Almatrafi
  • Sibtain Afzal
  • Khushnooda Ramzan
  • Holger Thiele
  • Peter Nürnberg
  • Sulman Basit
  • Brain Dev..2020 May;S0387-7604(20)30138-8. doi: 10.1016/j.braindev.2020.04.010.Epub 2020-05-10.

リンパ球-C-反応性タンパク質比率は、大腸がんの手術成績および腫瘍学的成績を予測する有望な新しいマーカーとして

Lymphocyte-C-reactive Protein Ratio as Promising New Marker for Predicting Surgical and Oncological Outcomes in Colorectal Cancer.
  • Yoshinaga Okugawa
  • Yuji Toiyama
  • Akira Yamamoto
  • Tsunehiko Shigemori
  • Shozo Ide
  • Takahito Kitajima
  • Hiroyuki Fujikawa
  • Hiromi Yasuda
  • Junichiro Hiro
  • Shigeyuki Yoshiyama
  • Takeshi Yokoe
  • Susumu Saigusa
  • Koji Tanaka
  • Yumiko Shirai
  • Minako Kobayashi
  • Masaki Ohi
  • Toshimitsu Araki
  • Donald C McMillan
  • Chikao Miki
  • Ajay Goel
  • Masato Kusunoki
  • Ann. Surg..2020 Aug;272(2):342-351. 00000658-202008000-00068. doi: 10.1097/SLA.0000000000003239.

心房細動のスクリーニングにおけるリズムモニタリング戦略の包括的評価。植え込み型ループレコーダーを用いて長期的にモニタリングされたリスクのある患者からの洞察

Comprehensive Evaluation of Rhythm Monitoring Strategies in Screening for Atrial Fibrillation: Insights From Patients at Risk Monitored Long Term With an Implantable Loop Recorder.
  • Søren Zöga Diederichsen
  • Ketil Jørgen Haugan
  • Christian Kronborg
  • Claus Graff
  • Søren Højberg
  • Lars Køber
  • Derk Krieger
  • Anders Gaarsdal Holst
  • Jonas Bille Nielsen
  • Axel Brandes
  • Jesper Hastrup Svendsen
  • Circulation.2020 May;141(19):1510-1522. doi: 10.1161/CIRCULATIONAHA.119.044407.Epub 2020-03-02.

COVID-19パンデミックとイブプロフェンまたはレニン-アンジオテンシン系遮断薬による治療:進行中の慢性治療の中断や変更は必要ない

COVID-19 pandemic and therapy with ibuprofen or renin-angiotensin system blockers: no need for interruptions or changes in ongoing chronic treatments.
  • Oliver Zolk
  • Susanne Hafner
  • Christoph Q Schmidt
  • Naunyn Schmiedebergs Arch. Pharmacol..2020 07;393(7):1131-1135. 10.1007/s00210-020-01890-6. doi: 10.1007/s00210-020-01890-6.Epub 2020-05-15.

COVID-19を有する入院中の高齢者における有罪率と死亡率。レトロスペクティブ観察研究

Frailty and Mortality in Hospitalized Older Adults With COVID-19: Retrospective Observational Study.
  • Robert De Smet
  • Bea Mellaerts
  • Hannelore Vandewinckele
  • Peter Lybeert
  • Eric Frans
  • Sara Ombelet
  • Wim Lemahieu
  • Rolf Symons
  • Erwin Ho
  • Johan Frans
  • Annick Smismans
  • Michaël R Laurent
  • J Am Med Dir Assoc.2020 Jul;21(7):928-932.e1. S1525-8610(20)30514-4. doi: 10.1016/j.jamda.2020.06.008.Epub 2020-06-09.

小豆のエチレン応答因子ファミリーのゲノムワイド解析と塩類アルカリストレス下でのVaERF3の機能決定

Genome-wide analysis of ethylene-response factor family in adzuki bean and functional determination of VaERF3 under saline-alkaline stress.
  • Wei-Yu Li
  • Cheng Wang
  • Heng-Hua Shi
  • Bo Wang
  • Jing-Xuan Wang
  • Yu-Shu Liu
  • Jing-Yu Ma
  • Sen-Ya Tian
  • Yao-Wen Zhang
  • Plant Physiol. Biochem..2020 Feb;147:215-222. S0981-9428(19)30535-2. doi: 10.1016/j.plaphy.2019.12.019.Epub 2019-12-17.

金ナノ粒子修飾スクリーン印刷電極を用いた分子インプリントポリマーをベースとした排水中のグリセロール定量用高感度・高選択性電気化学センサーの合成と特性評価

Synthesis and characterization of a highly sensitive and selective electrochemical sensor based on molecularly imprinted polymer with gold nanoparticles modified screen-printed electrode for glycerol determination in wastewater.
  • Soukaina Motia
  • Benachir Bouchikhi
  • Eduard Llobet
  • Nezha El Bari
  • Talanta.2020 Aug;216:120953. S0039-9140(20)30244-7. doi: 10.1016/j.talanta.2020.120953.Epub 2020-03-19.

高アンモニウム含有廃水処理のための単一反応器での部分硝化-アナモックスと短時間での硫黄自栄養脱窒の新規カップリングプロセス

A novel coupling process with partial nitritation-anammox and short-cut sulfur autotrophic denitrification in a single reactor for the treatment of high ammonium-containing wastewater.
  • Kuo Zhang
  • Tianli Kang
  • Sai Yao
  • Baorui Liang
  • Mingdong Chang
  • Youzhao Wang
  • Yongguang Ma
  • Liying Hao
  • Tong Zhu
  • Water Res..2020 Aug;180:115813. S0043-1354(20)30350-X. doi: 10.1016/j.watres.2020.115813.Epub 2020-04-27.

循環ミトコンドリアDNAとLPS結合タンパク質は、急性HIV感染では増加するが、細菌DNAは増加しない

Circulating mitochondrial DNA and LPS-binding protein but not bacterial DNA are increased in acute HIV infection.
  • Milena Nasi
  • Simone Pecorini
  • Sara De Biasi
  • Margherita Digaetano
  • Johanna Chester
  • Beatrice Aramini
  • Domenico Lo Tartaro
  • Marcello Pinti
  • Anna De Gaetano
  • Lara Gibellini
  • Anna Vittoria Mattioli
  • Cristina Mussini
  • Andrea Cossarizza
  • AIDS Res. Hum. Retroviruses.2020 Jul;doi: 10.1089/AID.2020.0098.Epub 2020-07-16.

エジプトでC型肝炎ウイルスに感染した患者から得られたヒトペギウイルス変異体の全ゲノム配列解析:症例報告

Whole-genome sequencing of human Pegivirus variant from an Egyptian patient co-infected with hepatitis C virus: a case report.
  • Hany K Soliman
  • Mohamed Abouelhoda
  • Mahmoud N El Rouby
  • Ola S Ahmed
  • G Esmat
  • Zeinab K Hassan
  • Mohammed M Hafez
  • Dina Ahmed Mehaney
  • Manojkumar Selvaraju
  • Rania Kamal Darwish
  • Yehia A Osman
  • Abdel-Rahman N Zekri
  • Virol. J..2019 11;16(1):132. 10.1186/s12985-019-1242-5. doi: 10.1186/s12985-019-1242-5.Epub 2019-11-11.

糖尿病ラット精巣に対するメラトニンの細胞レベル、ホルモンレベル、免疫組織化学的レベルでの保護作用

Protective action of melatonin on diabetic rat testis at cellular, hormonal and immunohistochemical levels.
  • Érique Ricardo Alves
  • Cintia Giselle Martins Ferreira
  • Maria Vanessa da Silva
  • Leucio Duarte Vieira Filho
  • Valdemiro Amaro da Silva Junior
  • Ismaela Maria Ferreira de Melo
  • Clovis José Cavalcanti Lapa Neto
  • Laís Caroline da Silva Santos
  • Álvaro Aguiar Coelho Teixeira
  • Valéria Wanderley Teixeira
  • Acta Histochem..2020 Jul;122(5):151559. S0065-1281(20)30058-1. doi: 10.1016/j.acthis.2020.151559.Epub 2020-05-26.

超音波頸動脈血流モニタリングにより評価した超カテーテル大動脈弁留置術中の高強度一過性信号。単一施設による前向き観察研究

High-intensity transient signals during transcatheter aortic valve implantation assessed by ultrasonic carotid artery blood-flow monitoring: A single center prospective observational study.
  • Shungo Aratake
  • Satoru Kayama
  • Yusuke Watanabe
  • Takahiro Honjo
  • Mae Harada
  • Taichi Onimaru
  • Shigehito Sawamura
  • J Cardiol.2020 Jul;S0914-5087(20)30212-4. doi: 10.1016/j.jjcc.2020.06.017.Epub 2020-07-13.

無血縁骨髄移植におけるHLA 1-3座ミスマッチと抗白血球グロブリン投与の影響

Influence of HLA 1-3-locus mismatch and antithymocyte globulin administration in unrelated bone marrow transplantation.
  • Koji Kawamura
  • Junya Kanda
  • Kazuteru Ohashi
  • Takahiro Fukuda
  • Koji Iwato
  • Tetsuya Eto
  • Shin-Ichiro Fujiwara
  • Takehiko Mori
  • Kentaro Fukushima
  • Yukiyasu Ozawa
  • Naoyuki Uchida
  • Takashi Ashida
  • Tatsuo Ichinohe
  • Yoshiko Atsuta
  • Yoshinobu Kanda
  • Ann. Hematol..2020 May;99(5):1099-1110. 10.1007/s00277-020-03995-7. doi: 10.1007/s00277-020-03995-7.Epub 2020-03-23.

IRSp53は、上皮性尿細管内腔での細胞膜の形状と偏光輸送を制御しています

IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules.
  • Sara Bisi
  • Stefano Marchesi
  • Abrar Rizvi
  • Davide Carra
  • Galina V Beznoussenko
  • Ines Ferrara
  • Gianluca Deflorian
  • Alexander Mironov
  • Giovanni Bertalot
  • Federica Pisati
  • Amanda Oldani
  • Angela Cattaneo
  • Ghazaleh Saberamoli
  • Salvatore Pece
  • Giuseppe Viale
  • Angela Bachi
  • Claudio Tripodo
  • Giorgio Scita
  • Andrea Disanza
  • Nat Commun.2020 Jul;11(1):3516. 10.1038/s41467-020-17091-x. doi: 10.1038/s41467-020-17091-x.Epub 2020-07-14.

新規なTRPM7/O-GlcNAc軸は、肺癌におけるc-Mycとcaveolin-1を安定化させることにより、腫瘍細胞の運動性と転移を媒介している

A novel TRPM7/O-GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma.
  • Sudjit Luanpitpong
  • Napachai Rodboon
  • Parinya Samart
  • Chanida Vinayanuwattikun
  • Siwaporn Klamkhlai
  • Pithi Chanvorachote
  • Yon Rojanasakul
  • Surapol Issaragrisil
  • Br. J. Cancer.2020 Jul;10.1038/s41416-020-0991-7. doi: 10.1038/s41416-020-0991-7.Epub 2020-07-20.

生殖期および閉経後のメキシコ女性における酸化ストレスのパラメータ

Parameters of Oxidative Stress in Reproductive and Postmenopausal Mexican Women.
  • Araceli Montoya-Estrada
  • Karla Guadalupe Velázquez-Yescas
  • Daniela Belen Veruete-Bedolla
  • José David Ruiz-Herrera
  • Alma Villarreal-Barranca
  • José Romo-Yañez
  • Guillermo Federico Ortiz-Luna
  • Arturo Arellano-Eguiluz
  • Mario Solis-Paredes
  • Arturo Flores-Pliego
  • Aurora Espejel-Nuñez
  • Guadalupe Estrada-Gutierrez
  • Enrique Reyes-Muñoz
  • Int J Environ Res Public Health.2020 02;17(5). E1492. doi: 10.3390/ijerph17051492.Epub 2020-02-26.

急性外傷性脳損傷におけるマスト細胞活性化、神経炎症、タイトジャンクション蛋白質の異常

Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury.
  • Duraisamy Kempuraj
  • Mohammad Ejaz Ahmed
  • Govindhasamy Pushpavathi Selvakumar
  • Ramasamy Thangavel
  • Sudhanshu P Raikwar
  • Smita A Zaheer
  • Shankar S Iyer
  • Casey Burton
  • Donald James
  • Asgar Zaheer
  • Mediators Inflamm..2020;2020:4243953. doi: 10.1155/2020/4243953.Epub 2020-06-24.

A Multiplexed HILIC-MS/HRMS Assay for Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials.有機カチオントランスポーター(OCT1)バイオマーカーとしてのイソブチリルカルニチン

A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker.
  • Lina Luo
  • Ragu Ramanathan
  • Lauren Horlbogen
  • Sumathy Mathialagan
  • Chester Costales
  • Manoli Vourvahis
  • Christopher L Holliman
  • A David Rodrigues
  • Anal. Chem..2020 Jul;doi: 10.1021/acs.analchem.0c01144.Epub 2020-07-02.

ラクトバチルス・プランタラムHEAL9の摂取は、急性ストレス時に可溶性フラクタルカインとCD163の炎症マーカーを減少させる。無作為化二重盲検プラセボ対照試験

Intake of Lactobacillus plantarum HEAL9 reduces the inflammatory markers soluble fractalkine and CD163 during acute stress: A randomized, double blind, placebo-controlled study.
  • Gunilla Önning
  • Magnus Hillman
  • Maria Hedin
  • Caroline Montelius
  • Joakim Eriksson
  • Siv Ahrné
  • Peter Jönsson
  • Physiol. Behav..2020 Jul;:113083. S0031-9384(20)30397-8. doi: 10.1016/j.physbeh.2020.113083.Epub 2020-07-17.

伸長因子-Tuは、tRNA選択のプルーフリーディング段階において、リボソーム内のアミノアシル-tRNAを繰り返し係合させることができる

Elongation factor-Tu can repetitively engage aminoacyl-tRNA within the ribosome during the proofreading stage of tRNA selection.
  • Justin C Morse
  • Dylan Girodat
  • Benjamin J Burnett
  • Mikael Holm
  • Roger B Altman
  • Karissa Y Sanbonmatsu
  • Hans-Joachim Wieden
  • Scott C Blanchard
  • Proc. Natl. Acad. Sci. U.S.A..2020 02;117(7):3610-3620. 1904469117. doi: 10.1073/pnas.1904469117.Epub 2020-02-05.

A Triad of Ketoacidosis, hypertriglyceridemia, and Acute Pancreatitis Associated With Sugar-Sweetened Soft Drinks Abuse in a Caucasian Patient With Uniagnosed Type 2 Diabetes Mellitus

A Triad of Ketoacidosis, Hypertriglyceridemia, and Acute Pancreatitis Associated With Sugar-Sweetened Soft Drinks Abuse in a Caucasian Patient With Undiagnosed Type 2 Diabetes Mellitus.
  • Alessandra Vitelli
  • Valentina Apuzzi
  • Francesco Calderaro
  • Olimpia Fattoruso
  • Vincenzo Bassi
  • Cureus.2020 May;12(5):e8299. doi: 10.7759/cureus.8299.Epub 2020-05-26.

バイオ炭とウレアーゼ・硝化抑制剤の複合施用は、水田におけるCH排出量削減に相乗効果を発揮する。3 年間の研究

Combined application of biochar with urease and nitrification inhibitors have synergistic effects on mitigating CH emissions in rice field: A three-year study.
  • Tiehu He
  • Junji Yuan
  • Jiafa Luo
  • Stuart Lindsey
  • Jian Xiang
  • Yongxin Lin
  • Deyan Liu
  • Zengming Chen
  • Weixin Ding
  • Sci. Total Environ..2020 Jul;743:140500. S0048-9697(20)34022-5. doi: 10.1016/j.scitotenv.2020.140500.Epub 2020-07-03.

南アフリカ、ムプマランガ州の急性発熱患者における細菌性人獣共通感染症の危険因子

Risk factors for bacterial zoonotic pathogens in acutely febrile patients in Mpumalanga Province, South Africa.
  • Amanda M Berrian
  • Beatriz Martínez-López
  • Vanessa Quan
  • Patricia A Conrad
  • Jacques van Rooyen
  • Gregory J G Simpson
  • John Frean
  • Jacqueline Weyer
  • Jennifer Rossouw
  • Darryn Knobel
  • Lucille Blumberg
  • Zoonoses Public Health.2019 08;66(5):458-469. doi: 10.1111/zph.12577.Epub 2019-03-11.

TP53突然変異のランドスケープを計算科学的に解析すると、頭頸部扁平上皮癌における予後の鍵となるシグネチャーと明確な経路が明らかになる

Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer.
  • Vito Carlo Alberto Caponio
  • Giuseppe Troiano
  • Iolanda Adipietro
  • Khrystyna Zhurakivska
  • Claudia Arena
  • Domenica Mangieri
  • Marco Mascitti
  • Nicola Cirillo
  • Lorenzo Lo Muzio
  • Br. J. Cancer.2020 Jul;10.1038/s41416-020-0984-6. doi: 10.1038/s41416-020-0984-6.Epub 2020-07-20.

樹脂抽出物の抗炎症性組成物は、ラットのモノヨードアセテート誘発性変形性関節炎における疼痛を緩和し、軟骨を保護する

An Anti-Inflammatory Composition of Resin Extracts Alleviates Pain and Protects Cartilage in Monoiodoacetate-Induced Osteoarthritis in Rats.
  • Venkata Krishnaraju Alluri
  • Sreenath Kundimi
  • Krishanu Sengupta
  • Trimurtulu Golakoti
  • Eswar Kumar Kilari
  • Evid Based Complement Alternat Med.2020;2020:7381625. doi: 10.1155/2020/7381625.Epub 2020-05-21.

経皮的冠動脈インターベンション成功後の急性心筋梗塞患者および糖尿病予備軍患者における、耐久性のあるポリマーと生分解性ポリマーをベースとした新世代の薬剤溶出ステントの比較

Comparison of Durable-Polymer- and Biodegradable-Polymer-Based Newer-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes After Successful Percutaneous Coronary Intervention.
  • Yong Hoon Kim
  • Ae-Young Her
  • Myung Ho Jeong
  • Byeong-Keuk Kim
  • Sung-Jin Hong
  • Seunghwan Kim
  • Chul-Min Ahn
  • Jung-Sun Kim
  • Young-Guk Ko
  • Donghoon Choi
  • Myeong-Ki Hong
  • Yangsoo Jang
  • Int Heart J.2020 Jul;doi: 10.1536/ihj.19-654.Epub 2020-07-18.

ラット後根神経節ニューロンにおけるKv7.2のRNA干渉を介したサイレンシングは、選択的チャネルオープナーの抗侵害受容作用を消失させることがわかった

RNA interference-mediated silencing of Kv7.2 in rat dorsal root ganglion neurons abolishes the anti-nociceptive effect of a selective channel opener.
  • Markus Valdor
  • Anke Wagner
  • Heike Fischer
  • Viola Röhrs
  • Wolfgang Schröder
  • Gregor Bahrenberg
  • André Welbers
  • Henry Fechner
  • Jens Kurreck
  • Thomas M Tzschentke
  • Thomas Christoph
  • J Pharmacol Toxicol Methods.2020 May - Jun;103:106693. S1056-8719(20)30022-8. doi: 10.1016/j.vascn.2020.106693.Epub 2020-04-08.

ペクチン修飾FeO NP上にPd NPを作製した。磁性ナノ触媒を用いたC-CおよびC-Nクロスカップリング反応と心血管保護効果の検討

Fabrication of Pd NPs on pectin-modified FeO NPs: A magnetically nanocatalyst for C-C and C-N cross coupling reactions and investigating the cardiovascular protective effects.
  • Wei Zhang
  • Hojat Veisi
  • Reyhaneh Sharifi
  • Delafarin Salamat
  • Bikash Karmakar
  • Malak Hekmati
  • Saba Hemmati
  • Zhiyong Zhang
  • Qiang Su
  • Mohammad Mahdi Zangeneh
  • Int. J. Biol. Macromol..2020 May;S0141-8130(20)33416-4. doi: 10.1016/j.ijbiomac.2020.05.247.Epub 2020-05-30.

多嚢胞性卵巣症候群-痰湿潤症候群のインスリン抵抗性を持つ不妊患者の卵巣顆粒膜細胞におけるIRS-1/PI3K/GLUT4経路の発現に対する電気鍼治療の効果

Effect of Electro-acupuncture on Expression of IRS-1/PI3K/GLUT4 Pathway in Ovarian Granulosa Cells of Infertile Patients with Polycystic Ovary Syndrome-Insulin Resistance of Phlegm-Dampness Syndrome.
  • Shan Xiang
  • Ming-Feng Xia
  • Jing-Yan Song
  • Dan-Qi Liu
  • Fang Lian
  • Chin J Integr Med.2020 Jun;10.1007/s11655-020-3219-z. doi: 10.1007/s11655-020-3219-z.Epub 2020-06-22.

血管周囲幹細胞由来シクロフィリンAはHIF1α依存性血管新生を介してアッシャーマン症候群の子宮環境を改善する

Perivascular Stem Cell-Derived Cyclophilin A Improves Uterine Environment with Asherman's Syndrome via HIF1α-Dependent Angiogenesis.
  • Mira Park
  • Seok-Ho Hong
  • So Hee Park
  • Yeon Sun Kim
  • Seung Chel Yang
  • Hye-Ryun Kim
  • Songmi Noh
  • Sunghun Na
  • Hyung Keun Lee
  • Hyunjung J Lim
  • Sang Woo Lyu
  • Haengseok Song
  • Mol. Ther..2020 May;S1525-0016(20)30249-5. doi: 10.1016/j.ymthe.2020.05.015.Epub 2020-05-20.

新生児集中治療室における抗菌薬の投与。臨床実践は薬物動態学に基づく推奨事項を反映しているか?

Dosing of Antimicrobials in the Neonatal Intensive Care Unit: Does Clinical Practice Reflect Pharmacokinetics-based Recommendations?
  • Ashley Stark
  • Julie Childers
  • Morgan England
  • Reese H Clark
  • Matthew Laughon
  • Michael Cohen-Wolkowiez
  • Daniel K Benjamin
  • P Brian Smith
  • Kelly Wade
  • Rachel G Greenberg
  • Pediatr. Infect. Dis. J..2020 Aug;39(8):713-717. 00006454-202008000-00014. doi: 10.1097/INF.0000000000002657.

FMRPを欠損したヒト多能性幹細胞由来の皮質神経細胞は、自然発火パターンの変化を示す

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns.
  • Shreya Das Sharma
  • Rakhi Pal
  • Bharath Kumar Reddy
  • Bhuvaneish T Selvaraj
  • Nisha Raj
  • Krishna Kumar Samaga
  • Durga J Srinivasan
  • Loren Ornelas
  • Dhruv Sareen
  • Matthew R Livesey
  • Gary J Bassell
  • Clive N Svendsen
  • Peter C Kind
  • Siddharthan Chandran
  • Sumantra Chattarji
  • David J A Wyllie
  • Mol Autism.2020 Jun;11(1):52. 10.1186/s13229-020-00351-4. doi: 10.1186/s13229-020-00351-4.Epub 2020-06-19.

慢性ストレスと咬合不安定性によって誘発される咀嚼筋機能障害に対するベンゾジアゼピンの有益な効果を動物実験で明らかにした

Beneficial effects of benzodiazepine on masticatory muscle dysfunction induced by chronic stress and occlusal instability in an experimental animal study.
  • Glauce C Nascimento
  • Bruno L Malzone
  • Daniela M Iyomasa
  • Yamba C L Pereira
  • João Paulo M Issa
  • Christie R A Leite-Panissi
  • Ii-Sei Watanabe
  • Mamie M Iyomasa
  • Ramon Fuentes
  • Elaine Del Bel
  • Fernando J Dias
  • Sci Rep.2020 May;10(1):8787. 10.1038/s41598-020-65524-w. doi: 10.1038/s41598-020-65524-w.Epub 2020-05-29.

臨床血圧測定のオブザーバーのパフォーマンスの最適化: Lancet Commission on Hypertension Groupからのポジションステートメント動脈圧測定におけるオブザーバーのパフォーマンスの最適化: Posicionamento do Grupo da

[Optimizing observer performance of clinic blood Pressure measurement: a position statement from the Lancet Commission on Hypertension GroupOtimização do desempenho do observador na medição clínica da pressão arterial: posicionamento do Grupo da ].
  • Raj Padwal
  • Norm R C Campbell
  • Aletta E Schutte
  • Michael Hecht Olsen
  • Christian Delles
  • Anthony Etyang
  • J Kennedy Cruickshank
  • George Stergiou
  • Michael K Rakotz
  • Gregory Wozniak
  • Marc G Jaffe
  • Ivor Benjamin
  • Gianfranco Parati
  • James E Sharman
  • Rev. Panam. Salud Publica.2020;44:e88. RPSP.2020.88. doi: 10.26633/RPSP.2020.88.Epub 2020-07-15.

網膜眼底写真における糖尿病性網膜症の検出のためのディープラーニングアルゴリズム。システマティックレビューとメタアナリシス

Deep learning algorithms for detection of diabetic retinopathy in retinal fundus photographs: A systematic review and meta-analysis.
  • Md Mohaimenul Islam
  • Hsuan-Chia Yang
  • Tahmina Nasrin Poly
  • Wen-Shan Jian
  • Yu-Chuan Jack Li
  • Comput Methods Programs Biomed.2020 Jul;191:105320. S0169-2607(19)31101-0. doi: 10.1016/j.cmpb.2020.105320.Epub 2020-01-16.

前立腺肥大症に対するホルミウムレーザーによる前立腺の核出術と経尿道的前立腺切除術との間の前立腺癌の診断価値:レトロスペクティブな比較研究

The diagnostic value of prostate cancer between holmium laser enucleation of the prostate and transurethral resection of the prostate for benign prostatic hyperplasia: A retrospective comparative study.
  • Gaofei He
  • Chengfang Sun
  • Yuanyuan Shu
  • Bohan Wang
  • Chuanjun Du
  • Jimin Chen
  • Jiaming Wen
  • Int J Surg.2020 Jul;79:217-221. S1743-9191(20)30408-8. doi: 10.1016/j.ijsu.2020.05.025.Epub 2020-05-21.

RGS4はPGE2生合成を阻害することで、アレルゲンやアスピリンに関連した気道過敏反応性を促進する

RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis.
  • Gordon S Wong
  • Jamie L Redes
  • Nariman Balenga
  • Morgan McCullough
  • Nathalie Fuentes
  • Ameya Gokhale
  • Cynthia Koziol-White
  • Joseph A Jude
  • Laura A Madigan
  • Eunice C Chan
  • William H Jester
  • Sabrina Biardel
  • Nicolas Flamand
  • Reynold A Panettieri
  • Kirk M Druey
  • J. Allergy Clin. Immunol..2020 Mar;S0091-6749(20)30372-9. doi: 10.1016/j.jaci.2020.03.004.Epub 2020-03-19.

組換えアディポネクチンペプチドは、Smad3 シグナル阻害を介して糖尿病マウスのミトコンドリアおよび ATF4-CHOP アポトーシス経路を抑制し、脳内出血後の神経細胞の生存を促進する

Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4-CHOP apoptosis pathways in diabetic mice via Smad3 signalling inhibition.
  • Xun Wu
  • Jianing Luo
  • Haixiao Liu
  • Wenxing Cui
  • Wei Guo
  • Lei Zhao
  • Hao Guo
  • Hao Bai
  • Kang Guo
  • Dayun Feng
  • Yan Qu
  • Cell Prolif..2020 Feb;53(2):e12759. doi: 10.1111/cpr.12759.Epub 2020-01-10.

プレグナンX受容体-シトクロムP450s軸の活性化:PEG化リポソームの強化された血液クリアランス促進現象の可能な理由

Activation of Pregnane X Receptor-Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo.
  • Fengling Wang
  • Huihui Wang
  • Yifan Wu
  • Lei Wang
  • Ling Zhang
  • Xi Ye
  • Daiyin Peng
  • Weidong Chen
  • Drug Metab. Dispos..2019 08;47(8):785-793. dmd.119.086769. doi: 10.1124/dmd.119.086769.Epub 2019-05-22.

切除不能な肝細胞がんに対する肝動脈化学塞栓療法とスニチニブ。PRODIGE 16試験の結果

Liver transarterial chemoembolization and sunitinib for unresectable hepatocellular carcinoma: Results of the PRODIGE 16 study.
  • Anthony Turpin
  • Thierry de Baere
  • Alexandra Heurgué
  • Karine Le Malicot
  • Isabelle Ollivier-Hourmand
  • Thierry Lecomte
  • Hervé Perrier
  • Julien Vergniol
  • David Sefrioui
  • Yves Rinaldi
  • Julien Edeline
  • Jean-Louis Jouve
  • Christine Silvain
  • Yves Becouarn
  • Barbara Dauvois
  • Mathieu Baconnier
  • Maryline Debette-Gratien
  • Gael Deplanque
  • Sébastien Dharancy
  • Côme Lepage
  • Mohamed Hebbar
  • Clin Res Hepatol Gastroenterol.2020 Jun;S2210-7401(20)30157-1. doi: 10.1016/j.clinre.2020.05.012.Epub 2020-06-21.