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歯周組織疾患と全身病変を合併した患者における口腔液中の免疫炎症反応の変化に関する研究
STUDY OF IMMUNE-INFLAMMATORY RESPONSE CHANGES IN ORAL FLUID IN PATIENTS WITH DISEASES OF PERIODONTAL TISSUES IN COMBINATION WITH GENERAL SOMATIC PATHOLOGY.
PMID: 37622497
抄録
目的:
歯周組織疾患と全身病変を合併した患者の口腔液中の免疫炎症反応マーカー（IL-1β, IL-10, IL-1β / IL-10, hsCRP）の濃度を測定する。
OBJECTIVE: The aim: To determine the concentration of markers of the immune-inflammatory response (IL-1β, IL-10, IL-1β / IL-10, hsCRP) in oral fluid in patients with diseases of periodontal tissues in combination with general somatic pathology.
患者および方法:
材料と方法本研究はウクライナのリヴィウにある Danylo Halytsky Lviv National Medical University, Department of therapeutic dentistry FPGE で実施された。患者は2つのグループに分けられた：メイングループ-144人の患者（一般的な体性病理を背景にした歯周組織疾患）、コントロールグループ-30人の体性・歯性健常者、その口腔液中のIL-1β、IL-10、hsCRP濃度を酵素免疫測定法により測定した。
PATIENTS AND METHODS: Materials and methods: The study was conducted at Danylo Halytsky Lviv National Medical University, Department of therapeutic dentistry FPGE, Lviv, Ukraine. The patients were divided into two groups: the main group - 144 patients (with periodontal tissue diseases on the background of general somatic pathology) and the control group - 30 somatically and dentally healthy persons, in whose oral fluid was determined the concentration of IL-1β, IL-10, hsCRP by the enzyme immunoassay method.
結果:
結果研究の結果、歯周組織疾患患者では、一般的な身体的病態を背景に、免疫炎症反応が活性化し、一般的な身体疾患および歯科疾患の経過を悪化させることが判明した。
RESULTS: Results: As a result of our research, it was found that in people with periodontal tissue diseases, against the background of general somatic pathology, there is an activation of the immune-inflammatory response, which aggravates the course of general somatic and dental diseases in this contingent of patients.
結論:
結論したがって、体性疾患を背景とする歯周組織疾患患者では、対照群と比較して、口腔液中の抗炎症性サイトカインIL-10の減少を背景に、炎症性サイトカインIL-1βおよびhsCRPの有意な増加が認められた。
CONCLUSION: Conclusions: Therefore, in patients with periodontal tissue diseases on the background of somatic diseases, a significant increase in the level of the pro-in-flammatory cytokine IL-1β and hsCRP was determined against the background of a decrease in the anti-inflammatory cytokine IL-10 in the oral fluid compared to the values in the control group.