糖尿病-歯周炎結膜における宿主応答調節療法：A Narrative Review

Host Response Modulation Therapy in the Diabetes Mellitus-Periodontitis Conjuncture: A Narrative Review.

抄録

歯周炎における宿主の炎症反応は、歯周破壊現象の発症と進展の根底にある現象である。歯周病がDM患者の状態を悪化させるのと同様に、糖尿病（DM）のような多くの全身性因子が歯周炎患者に悪影響を及ぼす可能性がある。宿主応答調節療法は、糖尿病患者のような組織喪失率の高い患者にとって重要な、炎症の解消、破壊プロセスの停止、歯周治癒の促進を目的とした抗炎症剤および抗酸化剤の使用を含む。本稿では、DMと歯周炎との関係、炎症反応を調節する主な物質（非ステロイド性抗炎症薬、抗菌薬に準ずる量のドキシサイクリン、オメガ3脂肪酸とその生成物、特殊なプロレゾルブメディエーター）、および糖尿病患者への適用に関する文献的データを概説する。

The inflammatory response of the host in periodontitis is the phenomenon that underlies the onset and evolution of periodontal destructive phenomena. A number of systemic factors, such as diabetes mellitus (DM), can negatively affect the patient with periodontitis, just as the periodontal disease can aggravate the status of the DM patient. Host response modulation therapy involves the use of anti-inflammatory and anti-oxidant products aimed at resolving inflammation, stopping destructive processes, and promoting periodontal healing, all important aspects in patients with high tissue loss rates, such as diabetic patients. This paper reviews the data available in the literature on the relationship between DM and periodontitis, the main substances modulating the inflammatory response (nonsteroidal anti-inflammatory drugs, sub-antimicrobial doses of doxycycline, or omega-3 fatty acids and their products, specialized pro-resolving mediators), as well as their application in diabetic patients.