エレクトロスピニング技術を用いたPVA-Co-PEナノファイバー膜の作製と特性評価

Preparation and Characterization of PVA-Co-PE Drug-Loaded Nanofiber Membrane by Electrospinning Technology.

• Si Sheng
• Xiaoying Yin
• Fangmei Chen
• Yixin Lv
• Lin Zhang
• Menghui Cao
• Yun Sun

抄録

本研究では、エレクトロスピニング技術を用いて、生体適合性が良好で薬物負荷が高いナノファイバー膜の新しい経皮吸収型ドラッグデリバリーシステムを開発した。ビニルアルコール-コ-エチレン（PVA-co-PE）ポリマーを紡糸マトリックスとし、非ステロイド性抗炎症薬（NSAID）スルリンダック（SUL）をモデル薬物として、SUL@PVA-co-PEナノファイバー膜を調製し、系統的に特徴付けを行った。薬剤を担持したナノファイバー膜の形態、分子振動遷移、熱重量特性、およびin vitroでの薬物放出・経皮吸収特性を解析した。その結果、PVA-co-PEナノファイバーの表面は、直径461nmから696nmの範囲で均一で滑らかであることが示された。これらの結果から、SUL@PVA-co-PEナノファイバー膜は、薬物の有効濃度に達するまで連続的に薬物を放出し、市販のパッチに比べて有意に高い薬物透過性を示すことが明らかになった。

A new transdermal drug delivery system of nanofiber membrane with good biocompatibility and high drug loading was developed by electrospinning technology in this study. Using vinyl alcohol-co-ethylene (PVA-co-PE) polymer as a spinning matrix and non-steroidal anti-inflammatory drug (NSAID) sulindac (SUL) as a model drug, the SUL@PVA-co-PE nanofiber membrane was prepared and characterized systematically. The morphology, molecular vibrational transitions, thermogravimetric attributes, and in vitro drug release and transdermal characteristics of drug-loaded nanofiber membranes were analyzed. The results indicated that the surface of PVA-co-PE nanofibers was uniform and smooth with the diameter ranged from 461 to 696 nm. Notably in vitro simulation experiments demonstrated that SUL@PVA-co-PE nanofiber membrane could provide a continuous drug release to reach the effective concentration of the drug, and exhibited significantly higher cumulative drug permeability compared to commercially available patches, Taken together, PVA-co-PE nanofiber membranes exhibited the characteristics of high drug loading and stability, and represented the potential to be utilized as a new transdermal drug delivery carrier with pronounced development prospect.