日本語AIでPubMedを検索
小児における起立性高血圧症の危険因子
Risk Factors for Orthostatic Hypertension in Children.
PMID: 32668285 DOI: 10.1016/j.jpeds.2020.07.030.
抄録
目的:
小児における起立性高血圧症の危険因子を調査する。
OBJECTIVE: To investigate the risk factors for orthostatic hypertension in children.
研究デザイン:
OHTを有する80人の子供がOHT群に登録され、51人の健康な子供が対照群となった。人口統計学的特徴、病歴、毎日の水分摂取量、夜間睡眠時間、起立検査の結果、全血球数を記録し、両群間で比較した。小児のOHTの危険因子はロジスティック回帰分析によって決定された。
STUDY DESIGN: Eighty children with OHT were enrolled in the OHT group, and 51 healthy children served as the control group. Demographic characteristics, clinical history, daily water intake, nightly sleep duration, the results of the standing test and complete blood count were recorded and compared between the two groups. The risk factors for pediatric OHT were determined by logistic regression analysis.
結果:
OHT群では、体格指数(BMI)と赤血球分布幅(RDW)が健常児よりも高かったが、1日の水分摂取量と睡眠時間は低かった。ロジスティック回帰分析の結果、過体重児、肥満児、1日の水分摂取量が800ml未満、RDWが1%増加した場合、OHTのリスクは6.0.069倍(95%CI:1.375~26.783、P<0.05)、7.482倍(95%CI:1.835~30.515、P<0.01)、4.027倍(95%CI:1.443~11.241、P<0.01)、または4.008倍(95%CI:1.698~9.461、P<0.01)と、それぞれ増加した。しかし、睡眠時間を1時間延長した場合、OHT発症リスクは74.3%(95%CI 54.6%~85.4%、P<0.01)低下した。
RESULTS: Body mass index (BMI) and red blood cell distribution width (RDW) were higher in the OHT group than in healthy children, whereas daily water intake and sleep duration were lower. Logistic regression analysis showed that if a child suffered from overweight, suffered from obesity, had a daily water intake less than 800 ml, or had a RDW that was increased by 1%, the risk of OHT would be increased by 6.069 times (95% CI: 1.375 to 26.783, P < 0.05), 7.482 times (95% CI 1.835 to 30.515, P < 0.01), 4.027 times (95% CI: 1.443 to 11.241, P < 0.01) or 4.008 times (95% CI 1.698 to 9.461, P < 0.01), respectively. However, if the sleep duration was increased by 1 hour, the risk of developing OHT would be decreased by 74.3% (95% CI 54.6% to 85.4%, P < .01).
結論:
BMIの増加、水分摂取量と睡眠時間の不足、およびRDWの上昇が小児OHTの危険因子として同定された。
CONCLUSION: Increased BMI, inadequate water intake and sleep duration, and elevated RDW were identified as risk factors for pediatric OHT.
Copyright © 2020 Elsevier Inc. All rights reserved.