中国人閉経後女性における骨密度と末梢血球数およびヘモグロビンとの関連．レトロスペクティブ研究

Association of bone mineral density with peripheral blood cell counts and hemoglobin in Chinese postmenopausal women: A retrospective study.

• Li Li
• Ji-Rong Ge
• Juan Chen
• Yun-Jin Ye
• Peng-Chao Xu
• Jian-Yang Li

抄録

骨粗鬆症（OP）とは、骨髄腔の構造変化を引き起こす代謝性骨疾患です。骨髄は成人の造血器官である。蓄積されたエビデンスにより、骨髄の造血機能と骨形成との間に密接な関係があることが示されています。いくつかの研究では、OPが造血と関連していることが明らかにされています。本研究では、中国人閉経後女性を対象に、末梢血球数（白血球[WBC]、赤血球[RBC]、血小板[PLT]）、ヘモグロビン[HGB]、骨密度[BMD]）との関連性を評価することを目的とした。これは閉経後女性673例を対象としたレトロスペクティブ研究である。腰椎と左股関節のBMDを二重エネルギーX線吸収法で測定した。その結果、閉経後女性のOP群のWBC、RBC、PLT、HGBの値は、非閉経群に比べてすべて高値であった。国や人種の違いにより、閉経後の女性のBMDと末梢血球数やHGBとの関連についての研究は少ない。そのため、より大規模なサンプル研究が必要である。

Osteoporosis (OP) is a metabolic bone disease that can cause structural changes in bone marrow cavity. Bone marrow is the hematopoietic organ of adults. Accumulating evidence has shown a close connection between bone marrow hematopoietic function and bone formation. Some studies have revealed that OP is associated with hematopoiesis. However, the relationship is not definite.This study aimed to evaluate the association between peripheral blood cell counts (white blood cells [WBC], red blood cells [RBC], platelets [PLT]), hemoglobin [HGB], and bone mineral density [BMD]) in a sample of Chinese postmenopausal women. This is a retrospective study involving 673 postmenopausal women cases. The BMD of lumbar spine and left hip joint were measured by dual-energy X-ray absorptiometry. The levels of blood cell counts and HGB were measured and analyzed.The study results showed the WBC, RBC, PLT, and HGB levels of postmenopausal women in the OP group were all higher than those in the non-osteoporosis group. Spearman linear trend analysis and partial correlation analysis demonstrated that BMD was negatively correlated with WBC, RBC, PLT, and HGB in postmenopausal women.Due to the differences between different countries and races, and there are few studies on the association of BMD with peripheral blood cell counts and HGB in Chinese Postmenopausal Women. Therefore, more large sample studies are needed.