猫の脾臓に浸潤した膵腺扁平上皮癌

Pancreatic adenosquamous carcinoma with invasion to the spleen in a cat.

• Kikumi Ogihara
• Hiroo Madarame

抄録

4歳半のスコティッシュフォールドの雌猫が膵臓部分切除術とエンブロック脾臓切除術を受けた。切除した標本は二相性の腫瘍で、組織学的および免疫組織化学的に膵腺扁平上皮癌（ASC）と診断された。腺がん成分と扁平上皮がん成分の間には緩やかな移行がみられた。扁平上皮がん成分は腫瘍の約30～40％を占めた。膵臓腫瘍が腓腹靱帯と脾臓に浸潤し、局所リンパ節転移と腸間膜転移を認めた。膵臓ASCは動物では報告されていない。これは脾臓に浸潤したネコの膵臓ASCの症例報告である。

A four-and-a-half-year-old female Scottish Fold cat underwent partial pancreatectomy with en-bloc splenectomy. The resected specimen was a biphasic tumor that was diagnosed histologically and immunohistochemically as pancreatic adenosquamous carcinoma (ASC), a ductal carcinoma variant according to the WHO classification of tumors in humans. There was a gradual transition between the adenocarcinoma component and the squamous cell carcinoma component. The squamous cell carcinoma component comprised approximately 30-40% of the tumor. A pancreatic tumor infiltrated into the gastrosplenic ligament and spleen with regional lymph node and mesenteric metastases. Pancreatic ASC has not been reported in animals. This is a case report of feline pancreatic ASC with splenic involvement.