ラマン分光法の口腔癌診断への応用

[Application of Raman Spectroscopy in the Diagnosis of Oral Cancer].

• Zhihui Zhu
• Fanhao Meng
• Jiabin Xia
• Xiaofeng Xu
• Yang Hu
• Aijin Zhang
• Tao Zhang

抄録

口腔癌は一般的で致命的な悪性腫瘍であり、癌治療では集学的治療（主に手術）が行われていますが、予後を良好にするためには早期診断と原発病変の完全除去が不可欠です。ラマン分光法は、光と物質の相互作用で生じる非弾性散乱光を検出する光学技術であり、生化学・生体分子構造や組織構造の振動スペクトルを検出することができ、細胞・組織・生体液の「分子フィンガープリント」を提供することができる。

Oral cancer is a common and deadly malignancy.While multidisciplinary treatment(mainly surgery)has been applied in the treatment of cancer treatment,early diagnosis and complete removal of the primary lesion are essential for a better prognosis.Raman spectroscopy is an optical technique that detects inelastic scattered light generated by the interaction of light and matter.It can detect the vibrational spectra of biochemical and biomolecular structures and tissue conformations,and can provide the "molecular fingerprint" for cells,tissues,and biological fluids.With the development of related technologies and optical instruments,Raman spectroscopy has been widely applied in medical fields.This article reviews the research advances and application of Raman spectroscopy in the diagnosis of oral cancer.