甲状腺乳頭癌の超音波所見、bFGF、局所浸潤性との相関性．

The correlation between ultrasonographic features, bFGF, and the local invasiveness of thyroid papillary carcinoma.

• Zhi-Ying Jia
• Xiu-Lan Wu
• Yin-Hua Zhang
• Bin-Lin Ma
• Fu-Cheng Ma

抄録

本研究では、甲状腺乳頭癌（PTC）の局所浸潤性と超音波所見、塩基性線維芽細胞増殖因子（bFGF）との相関を調べることを目的として、合計350検体の甲状腺結節を採取した。甲状腺結節350検体には結節性甲状腺腫90検体、巣状甲状腺炎36検体、PTC224検体が含まれていた。合計326個の甲状腺結節をbFGF検査した。その結果、良性群と悪性群のbFGF発現量の差は統計学的に有意であり（P"Zs_200A"<"Zs_200A".05）、浸潤性PTC群と非浸潤性PTC群のbFGF陽性発現量の差は統計学的に有意であった（P"Zs_200A"<"Zs_200A".05）。05）.PTCの形状が規則的かどうか、PTCに微小石灰化があるかどうかなどの超音波検査の特徴、病変の大きさや位置、患者の年齢などは、手術前の局所浸潤性の予備的な予測に役立ちます。術後のbFGFの検出は、PTCのさらなるリスク評価に役立つ。

The present study aimed to investigate the correlation between ultrasonographic features, basic fibroblast growth factor (bFGF), and the local invasiveness of papillary thyroid carcinoma (PTC).A total of 350 samples of thyroid nodules were collected. Routine ultrasonography was performed before the operation and routine pathological diagnosis and bFGF detection were performed after the operation.'These 350 samples of thyroid nodules included 90 samples of nodular goiter, 36 samples of focal thyroiditis, and 224 samples of PTC. A total of 326 thyroid nodules were examined for bFGF. The results revealed that the difference in the expression of bFGF between the benign and malignant groups was statistically significant (P < .05) and the difference in the positive expression of bFGF between the invasive and non-invasive PTC groups was statistically significant (P < .05).Whether the shape of PTC is regular or not and whether there is micro-calcification in PTC and other ultrasonographic features, the size and location of the lesions and the age of the patient help make a preliminary prediction of local invasiveness before the operation. Postoperative detection of bFGF is helpful for further risk assessments of PTC.