骨芽細胞性骨転移を呈したROS1再配列肺腺癌の1例

A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis.

• Yutaka Takahara
• Kouichi Yamamura
• Saki Matsuura
• Takashi Sakuma
• Kazuaki Nishiki
• Keisuke Nakase
• Masafumi Nojiri
• Ryo Kato
• Shohei Shinomiya
• Rieko Oikawa
• Yuki Fujimoto
• Taku Oikawa
• Kazuhiro Osanai
• Yoshimichi Ueda
• Shiro Mizuno

抄録

53歳女性がCT画像上に認められた胸部異常影の精密検査のため当院に紹介された。右S6結節影の経気管支肺生検の結果、肺腺癌と診断された。FDG-PET-CTではTh11とL2椎体にFDGの蓄積が認められ、骨芽細胞性骨病変が認められた。肺癌の骨芽細胞性骨転移は極めて稀であるため、CTガイド下骨生検を実施した。腫瘍はROS1再編成肺腺癌と診断され、クリゾチニブが投与され、原発性病変、転移性病変ともに改善した。肺癌の骨芽細胞性骨転移を呈したROS1再配列肺腺癌の1例を報告する。

A 53-year-old woman was referred to our hospital for detailed examination of abnormal chest shadows recognized on CT imaging. Transbronchial lung biopsy of a right S6 nodular shadow led to a diagnosis of lung adenocarcinoma. FDG-PET-CT showed FDG accumulation in the Th11 and L2 vertebral bodies and osteoblastic bone lesions. Since osteoblastic bone metastasis in lung cancer is extremely rare, CT-guided bone biopsy was performed. The tumor was diagnosed as ROS1-rearranged lung adenocarcinoma, for which crizotinib was administered, which led to improvement of both the primary and metastatic lesions. We report here a rare case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis of lung cancer.

© 2020 The Authors.