免疫ツルビジューム法による免疫グロブリン指標の検出：B型慢性肝炎患者

Detection of immunoglobulin indexes by immunoturbidimetry: patients with chronic hepatitis B.

• Zhiheng Li
• Yamei Yang

抄録

目的:

本研究の目的は、B型慢性肝炎患者における免疫グロブリンテストの臨床効果を探ることであった。

OBJECTIVE: The objective of this study was to explore the clinical effect of immunoglobulintest in patients with chronic hepatitis B.

方法:

宝吉市第三人民病院からB型慢性肝炎患者50名、肝不全患者50名、肝硬変患者50名を実験群として、健常者50名を対照群として選抜した。患者の血清中の免疫グロブリンM（IgM）、IgGおよびIgAのレベルは目標とされた処置の前と後にimmunoturbidimetryによってテストされた。

METHODS: Fifty patients with chronic hepatitis B, 50 patients with liver failure and 50 patientswith cirrhosis were selected from the Third People's Hospital of Baoji City as experimentalgroups, and 50 healthy people as the control group. The immunoglobulin M (IgM), IgG and IgA levels in serum of the patients were tested by immunoturbidimetry before and after targeted treatment.

結果:

治療前は、B型肝炎、肝不全、肝硬変患者のIg値は健常者に比べて有意に高く、B型肝炎患者のIg値は肝不全、肝硬変患者に比べて有意に低く、病状の進行に伴って異なる群の患者のIg値が有意に上昇していた。治療後、各群の患者のIg値は有意に低下し、治療成績が良好な実験群ではIg値が有意に低下し、病状が悪化した実験群ではIg値が有意に上昇した。

RESULTS: Before treatment, the level of Ig in patients with hepatitis B, liver failure and cirrhosis were significantly higher than those in normal people; the level of Ig in patients with hepatitis B were significantly lower than those in patients with liver failure and cirrhosis, and the level of Ig in patients in different groups increased significantly as the disease developed. After treatment, the level of Ig in patients in different groups decreased significantly; patients in the experimental group who had good treatment result had significant decrease of Ig level, while patients in the experimental group who had aggravated disease condition had significant increase of Ig level.

結論:

B型慢性肝炎患者の血清Ig値を検出することは、治療前後の患者の状態を把握し、適切な治療計画を立てる上で有効である。

CONCLUSIONS: Detection of serum Ig level in patients with chronic hepatitis B can effectively help determine the condition of patients before and after treatment, so as to formulate appropriate treatment plan.