複数の国際的なマウス施設におけるC57BL/6Nサブラインのオスマウスにおける足根損傷の発生

The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities.

• Eleanor Herbert
• Michelle Stewart
• Marie Hutchison
• Ann M Flenniken
• Dawei Qu
• Lauryl M J Nutter
• Colin McKerlie
• Liane Hobson
• Brenda Kick
• Bonnie Lyons
• Jean-Paul Wiegand
• Rosalinda Doty
• Juan Antonio Aguilar-Pimentel
• Martin Hrabe de Angelis
• Mary Dickinson
• John Seavitt
• Jacqueline K White
• Cheryl L Scudamore
• Sara Wells

抄録

C57BL/6N系の集団飼育雄性成体マウスにおいて、後肢足底脱臼が低頻度ではあるが持続的に観察されている。臨床症状としては、軽度から重度の片側性または両側性の足根外転、腫脹、後肢の形態異常、跛行などが突然発症した。複数の症例で指の収縮と歩行異常が認められた。放射線写真と組織学的検査で踵骨尾部脱臼と踵骨足根関節（踵骨-足根骨IV）の部分脱臼が認められた。5つの大型マウス生産・表現型センター（MRC Harwell、英国；The Jackson Laboratory、米国；The Centre for Phenogenomics、カナダ；German Mouse Clinic、ドイツ；Baylor College of Medicine、米国）におけるこの病理学の検出、頻度、原因について論じた。

Dislocation in hindlimb tarsals are being observed at a low, but persistent frequency in group-housed adult male mice from C57BL/6N substrains. Clinical signs included a sudden onset of mild to severe unilateral or bilateral tarsal abduction, swelling, abnormal hindlimb morphology and lameness. Contraction of digits and gait abnormalities were noted in multiple cases. Radiographical and histological examination revealed caudal dislocation of the calcaneus and partial dislocation of the calcaneoquartal (calcaneus-tarsal bone IV) joint. The detection, frequency, and cause of this pathology in five large mouse production and phenotyping centres (MRC Harwell, UK; The Jackson Laboratory, USA; The Centre for Phenogenomics, Canada; German Mouse Clinic, Germany; Baylor College of Medicine, USA) are discussed.