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明らかに健康な自動車運転手の交通公害ガス曝露に対する炎症マーカーの分析
Analysis of inflammatory markers in apparently healthy automobile vehicle drivers in response to exposure to traffic pollution fumes.
PMID: 32494251 PMCID: PMC7260889. DOI: 10.12669/pjms.36.4.2025.
抄録
研究目的:
本研究では、交通渋滞にさらされている健康なドライバーの炎症のパターンを評価することを目的としています。
Objective: This study aimed to evaluate pattern of markers of inflammation in apparently healthy drivers who exposed to traffic fumes.
方法:
Methods: This cross-sectional study was conducted from June 2016 to January 2017 at Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro. It looked into the effects of traffic pollutants on markers of inflammation including CRP, Leukocytes count, IL-6, TNF-α, TNF-β of healthy human volunteers. Eighty-seven, apparently healthy, non-smoking automobile vehicle drivers, having daily contact of traffic exhaust for at least six hours, aged between 18-40 years recruited for this study. Levels of traffic-generated pollutants P.M, P.M NO were recorded in different areas of Hyderabad City.
研究結果:
P.Mは、IL-6(=0.99)、TNF-α(=0.41)、CRP mg/dl(=0.99)、好中球(=0.29)、リンパ球(=0.31)、好酸球(=0.20)、単球(=0.42)、好塩基球(=0.16)を含む炎症マーカーと正の相関があることがわかった。IL-6(= 0.21)、TNF-α(= 0.49)とCRP mg/dl(= 0.22)%(= -0.31)、白血球(= 0.14)好中球(= 0.31)、リンパ球(= 0.21)、単球(= 0.50)、好塩基球(= 0。50)、好塩基球(= 0.17)とP.M. NOは、IL-6(= 0.22)、TNF-α(= 0.48)、CRP(= 0.22)、好中球(= 0.31)、リンパ球(= 0.13)、好塩基球(= 0.17)および単球(= 0.48)と正の相関を示した。
Results: P.M found to be positively correlated with markers of inflammation including IL-6 ( = 0.99), TNF-α ( = 0.41), CRP mg/dl ( = 0.99) , neutrophils ( = 0.29), lymphocytes ( = 0.31), eosinophils ( = 0.20), monocytes ( = 0.42) and basophils ( = 0.16). Positive correlation present among IL-6 ( = 0.21), TNF-α ( = 0.49) and CRP mg/dl ( = 0.22) % ( = -0.31), Leukocytes ( = 0.14) neutrophils ( = 0.31), lymphocytes ( = 0.21), monocytes ( = 0.50), basophils ( = 0.17) with P.M. NO showed positive correlation with IL-6 ( = 0.22), TNF-α ( = 0.48), CRP ( = 0.22), neutrophils ( = 0.31), lymphocytes ( = 0.13), basophils ( = 0.17) and monocytes ( = 0.48).
結論:
本研究の結果から、ほとんどすべての炎症マーカーが交通汚染物質と正の相関を示しており、この状態は全身疾患のリスクを高める可能性があることが示唆された。
Conclusion: Findings of our study suggest that almost all markers of inflammation are positively correlated with traffic pollutants and this condition might raise the risk of systemic diseases.
Copyright: © Pakistan Journal of Medical Sciences.