生後48時間における新生児の後天性口腔内細菌叢の検討

Acquired Oral Microflora of Newborns During the First 48 Hours of Life.

抄録

目的:

生後数時間と2日後の新生児の口腔内細菌叢を比較し、この期間に新生児が母親の細菌叢を獲得しているかどうかを明らかにすること。

OBJECTIVE: To compare the oral microflora of a newborn during first hours after birth and after two days, and determine whether the newborn acquires his mother's microflora during this period.

研究デザイン:

50人の新生児から、生後1日目、2日目、および母親から唾液を採取した。これらのサンプルは、総好気性培養細菌とミュータンスレンサ球菌についてチェックされた。

STUDY DESIGN: Saliva samples were taken from 50 newborns, on their first day of life, two days after, and from their mothers. Those samples were checked for total aerobic cultivated bacteria and mutans streptococci.

結果:

出生直後の口腔内には，ほとんどの新生児で検査対象微生物は存在しなかった．2日後，口腔内の微生物が検出された．母親と新生児の好気性培養細菌総数には有意な相関が認められた．

RESULTS: Soon after birth, most newborns lacked any of the tested microorganisms in their oral cavity. Two days later, oral microorganisms were detected. A significant correlation was found between the total aerobic cultivated bacteria counts of the mothers, and of their newborns.

結論:

新生児は、生後48時間以内に口腔内細菌叢の大部分を母親から獲得することが推測される。これらの結果は、生後間もない時期に、獲得した微生物叢を制御し、変化させ、新しい、しかし虫歯になりにくい微生物叢を作り出す可能性に光を当てるかもしれない。母親と新生児がまだ病院にいる間に、この最初の感染を避けるための正確なプロトコルを検討する必要があり、その結果、将来的に齲蝕の有病率を減少させることができるかもしれない。

CONCLUSIONS: It can be assumed, that on the first 48 hours of life, the newborn gains a major part of his oral microflora from his mother. These results might shade light on a possible to control and change the acquired microflora, at the very beginning of a human's life, creating a new, but less cariogenic flora. An accurate protocol should be examine to avoid this initial transmission during these days, while the mother and her newborn are still in the hospital, and thus might be possible to reduce caries prevalence in the future.