自己免疫性甲状腺疾患とそれに伴うリウマチ性疾患

[Autoimmune thyroid disease and associated rheumatic disorders].

• Djunajdar Kerimović-Morina

抄録

筋骨格系の症状は、甲状腺機能亢進症と甲状腺機能低下症の患者で認められた。この論文では、自己免疫性甲状腺疾患が甲状腺機能低下症と関連しているという利用可能な証拠をレビューします。シェーグレン症候群（SS）、全身性エリテマトーデス（SLE）、全身性硬化症、関節リウマチ（RA）、脊椎関節症。これらの症状の可能性のある病因は完全には確立されていません。シェーグレン症候群は自己免疫性甲状腺疾患患者の約1/10に発症する；SLEと抗甲状腺抗体を持つ患者は抗体を持たない患者に比べて有意に高齢であった。全身性硬化症と甲状腺疾患の患者は、抗体のない患者に比べて有意に若かった。甲状腺機能障害は、RAの女性では非炎症性リウマチ性疾患の女性に比べて3倍以上の頻度で認められ、甲状腺疾患のある人は関節炎の持続期間が短い傾向があった。

Musculosceletal manifestations were found in patients with hyperthyroidism as well as hypothyroidism. This article will review the available evidence that autoimmune thyroid disease is associated with: Sjögren's sydrome (SS), systemic lupus erythematosus (SLE), systemic sclerosis, rheumatoid arthritis (RA) and spondyloarthropathies. Possible pathogenesis of these manifestations has not been completely established. Sjögren's syndrome occurs in about 1/10 of patients with autoimmune thyroid disease; patients with SLE and antithyroid antibodies were significantly older than those pattiens without antibodies. Patients with systemic sclerosis and thyroid disease were significantly younger than those without antibodies. Thyroid disfunction was found three times more often in women with RA than in women with noninflammatory rheumatic diseases, and those with thyroid disease tended to have a shorter duration of arthritis.